has_circ_0016347 circRNA homo sapiens KCNH1 hsa_circ_0016347 GTCCTACAGCTGGGCTCAGACATCCTTCCCCAGTACAAGCAAGAGGCACCAAAGACTCCCCCTCACATCATCTTACATTATTGTGTTTTTAAGACCACGTGGGATTGGATCATCTTGATCTTGACCTTCTATACAGCCATCTTGGTCCCTTATAATGTCTCCTTCAAAACCAGGCAGAATAATGTGGCCTGGCTGGTTGTTGATAGCATCGTGGATGTTATCTTTTTGGTGGACATTGTGCTCAATTTTCATACCACCTTTGTTGGACCAGCAGGGGAGGTGATTTCTGACCCCAAACTTATCCGCATGAACTACCTGAAGACGTGGTTTGTGATTGACCTTCTGTCCTGTTTGCCATATGATGTCATCAACGCTTTTGAGAACGTGGATGAGGTTAGTGCCTTTATGGGTGATCCAGGGAAGATTGGTTTTGCTGATCAGATTCCACCACCACTGGAGGGGAGAGAGAGTCAGGGCATCAGCAGCCTGTTCAGCTCTCTAAAAGTTGTCCGGCTGCTCCGTCTTGGGCGAGTGGCCCGTAAGCTGGACCACTACATTGAATATGGAGCTGCTGTGCTGGTCCTGCTGGTGTGTGTGTTTGGGCTGGCTGCACACTGGATGGCCTGCATCTGGTACAGCATTGGGGACTATGAGATCTTTGACGAGGACACCAAGACAATCCGCAACAACAGCTGGCTGTACCAACTAGCGATGGACATTGGCACCCCTTACCAGTTTAATGGGTCTGGCTCAGGGAAGTGGGAAGGTGGTCCCAGCAAGAATTCTGTCTACATCTCCTCGTTGTATTTCACAATGACCAGCCTCACCAGTGTGGGCTTTGGGAACATCGCCCCATCCACAGACATTGAGAAGATCTTTGCAGTGGCCATCATGATGATTGGCT osteosarcoma 28424426 Circular RNA hsa-circ-0016347 promotes proliferation, invasion and metastasis of osteosarcoma cells. Jin H, Jin X, Zhang H, Wang W. Oncotarget. 2017 circ-0016347 levels are elevated in osteosarcoma qRT-PCR OS tissues and adjacent non-tumor tissues, hFOB, MG63, Saos-2 circ-0016347 promotes the proliferation, invasion and metastasis of osteosarcoma cells. circ-0016347 promotes caspase-1 expression and cell proliferation in osteosarcoma. loss of function MG63, Saos-2 Male BALB/c mice, 5 to 6 weeks old miR-214 circRNA-miRNA MG63, Saos-2 expression The circ-0016347 expression level was partly increased when miR-214 was inhibited compared to ells merely transfected with si-circRNA. Furthermore, circ-0016347 is positively orrelated with caspase-1, which could be reversed by iR-214 inhibitor. Collectively, these data illustrate that irc-0016347 negatively correlates with miR-214 and ndirectly influences the expression of caspase-1 in the steosarcoma cells. Caspase-1 has_circ_0063592 circRNA homo sapiens XRCC6 hsa_circ_0063592 GCTTCCAGCTGGTCTTTTTACCCTTTGCTGATGATAAAAGGAAGATGCCCTTTACTGAAAAAATCATGGCAACTCCAGAGCAGGTGGGCAAGATGAAGGCTATCGTTGAGAAGCTTCGCTTCACATACAGAAGTGACAGCTTTGAGAACCCCGTGCTGCAGCAGCACTTCAGGAACCTGGAGGCCTTGGCCTTGGATTTGATGGAGCCGGAACAAGCAGTGGACCTGACAT male infertile diseases 27958373 Identification and characterization of human testis derived circular RNAs and their existence in seminal plasma. Dong WW, Li HM, Qing XR, Huang DH, Li HG. Sci Rep. 2016 To validate these predicted circRNAs, 55 circRNAs of different abundance and lengths were randomly chosen for subsequent RT-PCR validation. Divergent primers were designed for circRNA detection. Among the 55 circRNAs, 30 of them could be specifically amplified. qRT-PCR human testis hsa_circ_006054 circRNA homo sapiens KIAA0355 hsa_circ_0006054 GCGACATCTAGACTAAGAGAAAGAGGCTGTGATGGTTGCCTGGCAGGAATTGAAGTTCAACAACTCTTTTGTTCTCAAAGTGCAGCAATTCCTGAGCACCAGCTAAAAGAACTGAACATAAAAATCGACAGTGCTTTGCAAGCATATAAGATAGCTCTGGAAAGCTTAGGACACTGTGAATATGCAATGAAAGCCGGCTTCCACCTGAATCCAAAGGCGATTGAAGCAAGTTTGCAGGGCTGCTGCAGCGAGGCGGAAGCCCAGCAGACGGGGCGGAGGCAGACACCCCCGCAGCCCATGCAGTGTGAGCTCCCCACCGTCCCTGTGCAGATAGGATCGCACTTCCTGAAGGGCGTCTCCTTTAATGAGTCGGCCGCCGACAATCTGAAACTTAAGACGCATACAATGTTACAGCTGATGAAGGAGGCAGGCTGCTATAATGGAATCACATCCAGGGATGATTTTCCTGTGACTGAAGTGCTGAACCAGGTTTGCCCTTCCACATGGCGAGGTGCCTGCAAGACGGCGGTGCAGCTGCTGTTTGGCCAGGCTGGACTG breast cancer 28484086 Identification of circular RNAs as a promising new class of diagnostic biomarkers for human breast cancer. Lü L, Sun J, Shi P, Kong W, Xu K, He B, Zhang S, Wang J. Oncotarget. 2017 downregulated microarray, qRT-PCR Breast cancer lesions and adjacent normal-appearing tissues area under the curve (AUC) is 0.71 Breast cancer lesions and adjacent normal-appearing tissues hsa_circ_0000026 circRNA homo sapiens EIF4G3 hsa_circ_0000026 hsa_circ_000559 CAATCCCACAGAGTATTGATGAGGAAACTGAAGTTTGGAGCGATCACATCATTTTCCCAAGAATTCCTAGAGGACCTGTGCAACAACCTCTTGAGGATCGAATCTTCACTCCCGCTGTCTCAGCAGTCTACAGCACGGTAACACAAGTGGCAAGACAGCCGGGAACCCCTACCCCATCCCCTTATTCAGCACATGAAATAAACAAGGGGCATCCAAATCTTGCGGCAACGCCCCCGGGACATGCATCGTCCCCTGGACTCTCTCAA gastric cancer 28737829 Expression profile of circular RNAs in human gastric cancer tissues. Huang YS, Jie N, Zou KJ, Weng Y. Mol Med Rep. 2017 downregulated microarray, qRT-PCR GC tissues and adjacent normal tissues circRNA PUM1 circRNA homo sapiens PUM1 hsa_circ_0000043 hsa_circ_001967 GGCCCAAGGGATGCAGACAGTGATGAAAACGACAAAGGTGAAAAGAAGAACAAGGGTACGTTTGATGGAGATAAGCTAGGAGATTTGAAGGAGGAGGGTGATGTGATGGACAAGACCAATGGTTTACCAGTGCAGAATGGGATTGATGCAGACGTCAAAGATTTTAGCCGTACCCCTGGTAATTGCCAGAACTCTGCTAATGAAGTGGATCTTCTGGGTCCAAACCAGAATGGTTCTGAGGGCTTAGCCCAGCTGACCAGCACCAATGGTGCCAAGCCTGTGGAGGATTTCTCCAACATGGAGTCCCAGAGTGTCCCCTTGGACCCCATGGAACATGTGGGCATGGAGCCTCTTCAGTTTGATTATTCAGGCACGCAGGTACCTGTGGACTCAGCAGCAGCAACTGTGGGACTTTTTGACTACAATTCTCAACAACAG 25558066 Analysis of intron sequences reveals hallmarks of circular RNA biogenesis in animals. Ivanov A, Memczak S, Wyler E, Torti F, Porath HT, Orejuela MR, Piechotta M, Levanon EY, Landthaler M, Dieterich C, Rajewsky N. Cell Rep. 2015 This circRNA with top H score and high/medium expression of the host transcript was (1) resistant to RNase R and (2) had the predicted head-to-tail junctions, as validated by Sanger sequencing, suggesting that the circRNA exists in circularized form in HEK293 cells. qRT-PCR, sanger sequencing HEK293 cells hsa_circ_0000064 circRNA homo sapiens B4GALT2 hsa_circ_0000064 hsa_circ_001565 GTGGCGAGTCAGGACAGGGTGGCAGCGTGGGAGCCGTGGGACCGGGCAGGGCACTGGGGACCTCAGGGAGCCCGGAGCTAGAGGCGGTGGCGTTGGGCCGGGAGCAGTTGCTGCTGCTGCTGCTGCTGCTAGCAGCTGG lung cancer 29223555 Emerging roles of circular RNA hsa_circ_0000064 in the proliferation and metastasis of lung cancer. Luo YH, Zhu XZ, Huang KW, Zhang Q, Fan YX, Yan PW, Wen J. Biomed Pharmacother. 2017 hsa_circ_0000064 remarkably up-regulate in lung cancer qRT-PCR, FISH lung cancer and paired normal tissues, A549 and H1299 Hsa_circ_0000064 regulated cell proliferation, cell apoptosis and cell cycle. Hsa_circ_0000064 modulated cell migration and invasion. loss of function A549 and H1299 hsa_circ_0000069 circRNA homo sapiens STIL hsa_circ_0000069 hsa_circ_001061 GTCTTCCCAAAAGTTATCTTCTGGGAAGATGCCAATACATGATCACGACTCTGGTGTTGAAGATGAAGATTTTTCTCCAAGACCAATTCCTAGTCCTCATCCAGTGAGTCAGAAGATTTCTAAGATCCAACCATCAGTTCCTGAACTTTCACTTGTGTTGGATGGCAATTTCATAGAATCAAACCCTCTGCCTACTCCATTGGAAATGGTGAATAATGAAAATCCTCCTTTGATTAACCACTTGGAACACTTGAAGCCATTGCAACCCCAGCTTTATGATGAGAAACACAGTCCAGAAGTTGAAGCTGGAGAGCCTTCCTTGAGAGGAATACCAAATCAGTTAAACCAGGATAAACCAGCTCTTTTGAGACACTGCAAAGTAAGACAGCCACCTGCCTATAAGAAAGGGAACCCCCATACCAGGAACAGTATTAAACCATCTTCTCATAATGGGCCATCTCATGATATATTTGAAAAGCTCCAAACAGTTTCTGCTGGAAATGTACAAAACGAAGAGTATCCTATAAGACCCTCCACACTTAATTCTAGGCAGTCTTCTCTTGCCCCGCAGTCCCAACCACACGATTTTGTTTTTTCACCCCATAATTCAGGAAGACCAATGGAACTTCAGATACCTACTCCCCCACTGCCATCTTACTGTTCCACAAACGTTTGCAGGTGTTGTCAGCATCATAGTCATATTCAATATAGTCCGCTAAATTCTTGGCAAGGAGCAAACACAGTTGGATCCATTCAAGATGTCCAGTCTGAAGCCCTTCAAAAGCATTCATTATTTCACCCAAGTGGATGTCCAGCCCTGTACTGTAATGCATTCTGTTCTTCAAGTAGTCCTATAGCCTTGAGACCTCAGGGAGATATGGGCAGTTGTTCTCCCCACAGCAATATTGAACCATCGCCTGTGGCAAGACCGCCTTCACATATGGACTTATGTAACCCACAGCCTTGCACAGTGTGCATGCACACACCCAAGACTGAGTCAGATAATGGAATGATGGGACTATCTCCAGATGCATATCGGTTCCTCACAGAACAAGACAGACAGCTAAGACTACTTCAGGCACAG Colorectal cancer 28003761 Comprehensive profile of differentially expressed circular RNAs reveals that hsa_circ_0000069 is upregulated and promotes cell proliferation, migration, and invasion in colorectal cancer. Guo JN, Li J, Zhu CL, Feng WT, Shao JX, Wan L, Huang MD, He JD. Onco Targets Ther. 2016 upregulated in CRC qRT-PCR paired CRC tissues and adjacent noncancerous tissues, HCO, HT-29, LoVo, HCT-116 and SW480 hsa_circ_0000069 knockdown could notably inhibit cell proliferation, migration, and invasion, and induce G0/G1 phase arrest of cell cycle in vitro. loss of function HT-29 hsa_circ_0000096 circRNA homo sapiens HIAT1 hsa_circ_0000096 hsa_circ_001013 CCTCAAGGAATAGGTTCTCCTAGTGTCTATCATGCAGTTATCGTCATCTTTTTGGAGTTTTTTGCTTGGGGACTATTGACAGCACCCACCTTGGTGGTATTACATGAAACCTTTCCTAAACATACATTTCTGATGAACGGCTTAATTCAAGGAGTAAAGGGTTTGTTGTCATTCCTTAGTGCCCCGCTTATTGGTGCTCTTTCTGATGTTTGGGGCCGAAAATCCTTCTTGCTGCTAACGGTGTTTTTCACATGTGCCCCAATTCCTTTAATGAAGATCAGCCCATGGTGGTACTTTGCTGTTATCTCTGTTTCTGGGGTTTTTGCAGTGACTTTTTCTGTGGTATTTGCATACGTAGCAGATATAACCCAAGAGCATGAAAGAAGTATGGCTTATGGACTGGTTTCAGCAACATTTGCTGCAAGTTTAGTCACCAGTCCTGCAATTGGAGCTTATCTTGGACGAGTATATGGGGACAGCTTGGTGGTGGTCTTAGCTACAGCAATAGCTTTGCTAGATATTTGTTTTATCCTTGTTGCTGTGCCAGAGTCGTTGCCTGAGAAAATGCGGCCAGCATCCTGGGGAGCACCCATTTCCTGGGAACAAGCTGACCCTTTTGCGTCCTTAAAAAAAGTCGGCCAAGATTCCATAGTGCTGCTGATCTGCATTACAGTGTTTCTCTCCTACCTACCGGAGGCAGGCCAATATTCCAGCTTTTTTTTATACCTCAGACAGATAATGAAATTTTCACCAGAAAGTGTTGCAGCGTTTATAGCAGTCCTTGGCATTCTTTCCATTATTGCACAG gastric cancer 28081541 Circular RNA 0000096 affects cell growth and migration in gastric cancer. Li P, Chen H, Chen S, Mo X, Li T, Xiao B, Yu R, Guo J. Br J Cancer. 2017 significantly downregulated in gastric cancer qRT-PCR paired gastric cancer tissues and adjacent non-tumorous tissues, GES-1, AGS, BGC-823, HGC-27, SGC-7901 and MGC-803 The area under the receiver operating characteristic (ROC) curve (AUC) was 0.82.Knockdown of hsa_circ_0000096 significantly inhibited cell proliferation and migration in vitro and in vivo. loss of function GES-1, AGS, BGC-823, HGC-27, SGC-7901 and MGC-803 male BALB/c nude mice aged 6 weeks paired gastric cancer tissues and adjacent non-tumorous tissues hsa_circ_0000098 circRNA homo sapiens SLC30A7 hsa_circ_0000098 hsa_circ_001351 CTTAGGCTTGATTTCCGACTCTTTTCACATGTTTTTCGATAGCACTGCCATTTTGGCTGGACTGGCAGCTTCTGTTATTTCAAAATGGAGAGATAATGATGCTTTCTCCTATGGGTATGTTAGAGCGGAAGTTCTGGCTGGCTTTGTCAATGGCCTATTTTTGATCTTCACTGCTTTTTTTATTTTCTCAGAAGGAGTTGAGAGAGCATTAGCCCCTCCAGATGTCCACCATGAGAGACTGCTTCTTGTTTCCATTCTTGGGTTTGTGGTAAACCTAATAGGAATATTTGTTTTCAAACATGGAGGTCATGGACATTCTCATGGCTCTGGCCACGGACACAGTCATTCCCTCTTTAATGGTGCTCTAGATCAGGCACATGGCCATGTCGATCATTGCCATAGCCATGAAGTGAAACATGGTGCTGCACATAGCCATGATCATGCTCATGGACATGGACACTTTCATTCTCATGATGGCCCGTCCTTAAAAGAAACAACAGGACCCAGCAGACAGATTTTACAAGGTGTATTTTTACATATCCTAGCAGATACACTTGGAAGTATTGGTGTAATTGCTTCTGCCATCATGATGCAAAATTTTGGTCTGATGATAGCAGATCCTATCTGTTCAATTCTTATAGCCATTCTTATAGTTGTAAG breast cancer 28744405 Circular RNA circ-ABCB10 promotes breast cancer proliferation and progression through sponging miR-1271. Liang HF, Zhang XZ, Liu BG, Jia GT, Li WL. Am J Cancer Res. 2017 up-regulated in breast cancer microarray, qRT-PCR cancer and adjacent noncancerous tissue circMAN1A2 circRNA homo sapiens MAN1A2 hsa_circ_0000118 hsa_circ_002173 GGAAGAGGAAGAACGTCTGAGAAATAAAATTCGAGCTGATCATGAGAAGGCCTTGGAAGAAGCAAAAGAAAAATTAAGAAAGTCAAGAGAGGAAATTCGAGCAGAAATTCAGACAGAGAAAAATAAGGTAGTCCAAGAAATGAAGATAAAAGAGAACAAGCCACTGCCACCAGTCCCTATTCCCAACCTTGTAGGAATACGTGGTGGAGACCCAGAAGATAATGACATAAGAGAGAAAAGGGAAAAAATTAAAGAGATGATGAAACATGCTTGGGATAACTATAGGACATATGGGTGGGGACATAATGAACTCAGACCTATTGCAAGGAAAGGACACTCCCCTAACATATTTGGAAGTTCACAAATGGGTGCTACCATAGTAGATGCTTTGGATACCCTTTATATCATGGGACTTCATGATGAATTCCTAGATGGGCAAAGATGGATTGAAGACAACCTTGATTTCAGTGTGAATTCAGAGGTGTCTGTGTTTGAAGTCAACATTCGATTTATTGGAGGCCTACTTGCAGCATATTACCTATCAGGAGAGGAG 29074849 The circular RNA circBIRC6 participates in the molecular circuitry controlling human pluripotency. Yu CY, Li TC, Wu YY, Yeh CH, Chiang W, Chuang CY, Kuo HC. Nat Commun. 2017 Eenriched in hESCs (>0.1% of GAPDH levels). Downregulated in Ebs, upregulated in induced pluripotent stem cells (iPSCs) as compared with the parental fibroblasts. qRT-PCR Human embryonic stem cells, induced pluripotent stem cells hsa_circ_0000144 circRNA homo sapiens SLAMF6 hsa_circ_0000144 hsa_circ_001622 GAGAGAGGTAGAACTAAGCAGATTCTGAAAAAGAGAGAAAAGTCAAGGAACTTTGGGTTTCTAACCTGAGGGACTAGCTTAGGCCCATCTATAGCTAACAGGAATATAGCAAGCTGTGTTAGCTCCACAGGAGGCAAATGCAGTATGAAAGAGAGTAGGGGCTGATTTCTCAAGAGAATTTAAAGAGAAGGGAGGAGAAACATAGTCAGGATATTGAGAAGGTAGGACAAATGGAAGTTACTCTTTAGGTAACAGAGTCCTGAGCAAATTTGGAGCAAAGGGAAGCAGCTGGGAGAAAAAGAAAAAACTTAAGATATGGTGAAAGGGA gastric cancer 28737829 Expression profile of circular RNAs in human gastric cancer tissues. Huang YS, Jie N, Zou KJ, Weng Y. Mol Med Rep. 2017 upregulated microarray, qRT-PCR GC tissues and adjacent normal tissues hsa_circ_0000172 circRNA homo sapiens CSRP1 hsa_circ_0000172 hsa_circ_001363 CTGGGAAGTGATAAAGGGGCTGGTATTGAGCACATTTAAAGCAAATCACAATGTGTTAGCTAACAATCAGCCCTCTGAGGCAGGTATTGTATCTACTGGTACAGACTAGAGAATATTTTGCATGCTTCTGGTTCTGGTGCTGTTGTGAACTAACCAGGACCCAGGAATCGGCTGGAGCAATAGTGGGCTCAGGCTCTGCCTAGAGCCCTGGGCTCCAGCCACCCACCAGCTGCTCCCTGAGAGTGAATGAATGGGCAGGCTCTCCCCACGCTGGGATACTATCACAGTGGCACCGAGGAAATCCACTGGGCCCTGGTAGAAAGTATATCAGTATATCATGAAGAGGTGGCTTGGAGTCTTG bladder cancer 29558461 Molecular and Bioinformatics Analyses Identify 7 Circular RNAs Involved in Regulation of Oncogenic Transformation and Cell Proliferation in Human Bladder Cancer. Cai D, Liu Z, Kong G. Med Sci Monit. 2018 up microarray, qRT-PCR bladder carcinoma (high-grade and low-grade) with resection specimens containing adjacent normal bladder tissue circEKL4 circRNA homo sapiens ELK4 hsa_circ_0000175 hsa_circ_001035 CTCATTGCTATGGACAGTGCTATCACCCTGTGGCAGTTCCTTCTTCAGCTCCTGCAGAAGCCTCAGAACAAGCACATGATCTGTTGGACCTCTAATGATGGGCAGTTTAAGCTTTTGCAGGCAGAAGAGGTGGCTCGTCTCTGGGGGATTCGCAAGAACAAGCCTAACATGAATTATGACAAACTCAGCCGAGCCCTCAGATACTATTATGTAAAGAATATCATCAAAAAAGTGAATGGTCAGAAGTTTGTGTACAAGTTTGTCTCTTATCCAGAGATTTTGAACATGGATCCAATGACAGTGGGCAGGATTGAGGGTGACTGTGAAAGTTTAAACTTCAGTGAAGTCAGCAGCAGTTCCAAAGATGTGGAGAATGGAGGGAAAGATAAACCACCTCAGCCTGGTGCCAAGACCTCTAGCCGCAATGACTACATACACTCTGGCTTATATTCTTCATTTACTCTCAACTCTTTGAACTCCTCCAATGTAAAGCTTTTCAAATTGATAAAGACTGAGAATCCAGCCGAGAAACTGGCAGAGAAAAAATCTCCTCAGGAGCCCACACCATCTGTCATCAAATTTGTCACGACACCTTCCAAAAAGCCACCGGTTGAACCTGTTGCTGCCACCATTTCAATTGGCCCAAGTATTTCTCCATCTTCAGAAGAAACTATCCAAGCTTTGGAGACATTGGTTTCCCCAAAACTGCCTTCCCTGGAAGCCCCAACCTCTGCCTCTAACGTAATGACTGCTTTTGCCACCACACCACCCATTTCGTCCATACCCCCTTTGCAGGAACCTCCCAGAACACCTTCACCACCACTGAGTTCTCACCCAGACATCGACACAGACATTGATTCAGTGGCTTCTCAGCCAATGGAACTTCCAGAGAATTTGTCACTGGAGCCTAAAGACCAGGATTCAGTCTTGCTAGAAAAGGACAAAGTAAATAATTCATCAAGATCCAAGAAACCCAAAGGGTTAGAACTGGCACCCACCCTTGTGATCACGAGCAGTGATCCAAGCCCACTGGGAATACTGAGCCCATCTCTCCCTACAGCTTCTCTTACACCAGCATTTTTTTCACAGGTAGCTTGCTCGCTCTTTATGGTGTCACCATTGCTTTCATTTATTTGCCCTTTTAAGCAAATCCAGAATTTATACACTCAAGTTTGCTTTCTGTTACTTAGGTTTGTCTTAGAAAGGTTATGTGTGACTGTCATGTGAAAGTTACCCCATTTCTCATCTTAATTAGGATTGCTAAAATAGAAAGTTTGGAGTATTTTCTTAAAAAATTCATTGTTCTACAAGTAAATAAATATTTTGATTTTTCTATTTCCTCCTAAAGAAAGTACACACACTCTCTCGCTCTCTCTCGGTCTTATAAAACTCGTTGGTGTCTTATAAAACAAACAGTGATAATCTCAAGTTAGAAAACAGTAGGTCCTGAGAACCATAAGAAAAATGACTGGTGTGATGTTGAGTAACAAGTTGGTACAGTTACTTTAGCTATTTATTAACTTGCTCATCTCATAGAACATTTTAGTAGATTTTTCACACACCTCATTATTAAAAAAAAACAAACATGCTGGTGTCTTGGTTACCCATTATTCCTCTGTACCTGAATTCAGGTTGGTTTTTCTATTTGGAAAAGACTTTATAAATGTTGGCTTAAAAAGAGGTTGAGCACCAGAATCTCAGAATTTACCACCAAAGAACTCATCCATGTAACCAAAAACCACTTGTACCCCCAAAAACTATTGAAATAAAAATTTAAAAAATTTTAAGTAGTTATTATCACCTTTATCCCTCTTAGTTTGTAAAAATAATTTTTGAGTTTTGTCATGATAATATTTCAGACTTGGAGATATTTGGAGTGGAGGATAGGGCAATATTTAGGTTTGGGTTATTTGTGTGCTGTTTCAAGGATAAAACATCCTGGTAAGTCAGTCAGTGAATATTTTTGCTTTGTGTATTGCAGACACCCATCATACTGACTCCAAGCCCCTTGCTCTCCAGTATCCACTTCTGGAGTACTCTCAGTCCTGTTGCTCCCCTAAGTCCAGCCAGACTGCAAGGTGCTAACACACTTTTCCAGGTAATTTTATAAATATCTGTCTTCTGTAGTTGGAGCATGTTAAATGAAGAAAGAGGCAAAAAGGCAGGGTCCCACTATTCAGTTTAATCATTATAAAACTTCTATTTAATGAATATTCTTTTTTTATTTTTTTGAGATGGAGTCCTCACCATGTCACCCAGGCTGGAGTGCAGTGGCATAATCTCAGCTCACTGCAACCTGCACCTTCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCGGAGTAGCTAAGATTACAGGTGTGCAACACCACGTCTGGTTGATTTTTGTGTTTTTAGTGAGACAGGGTTTGACCATGTTGTCCAGACTGGTCTCCAACTCCTGACCTCAGGTGATCCGCCCACCTTGGCCTCCCAAAGTGTTGGGATTACAGGCATGAGCCATTGTGCCCTGCCCAATGAATATTCTTTAGATTTATTTTTGAATTTCCAAATATTAATTTTCTAGCTGGCAAACAGCTTGAATAAATATAGCAAAGTTTCATTTTCATTATTTACTATTACATACATTTGAGTTAGACCAAGAATTGTTCAATACTGTAGGAGATTTAGAGCCTACCCCAAGTTTTTGTCACTAGAAATTCTCTATTTAAAAAAAAAAAATGGGCCAGGCAGTGTGTGTGTCATGCCTGTAATCCCAGCGCTTTGGTAGGCCGAGGCAGGAAGATTGCTTGAGCTCAGGAGTTTGAGACCAGCCTGGACAACCTAAGGAGACCTTGTCTGTACTAGAAATAAAAAAAATTAAGTTAGGCATGGTAGCACGTGCCTGTGGCCCCTAGAGCTACTTGGGAGGCTGAGGTGGGAGGACCGCTTGAGCCCAGTAGATCAAGGCTGCAGTGAGCTATAATGGCACCGCTGCACTCCGGCCTGGGTGACACAGTGAGACCTTGTCTCAAAAAAACAAAATCCACACACACACACTCTCTCTCTCTCTCTTGCTCTCTCTCTCTCTCACACACACACACACACACATATATGGGGGATCTCTGCACATAGGTTCCCTCTTTTAATTAAAGATTAAAAAAAATTTTTTTTTGAGGCGGAGTTTTGCTCTTGTTGTCCAGGCCAGAATGCAATGGCACGATCTCAGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGCGGTTCTCCTGCCTCAGCCTCCCGAGTAGCCAGGATTATAGGCATGTGCCACCATGCTAGGCTAATTTTGTATTTTTAGTAGAGACGAGGTTTCTTCATGTTGATCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCGCCCGCCTCAGCCTCCCGAAGTGCTGGGATTACAGGCATGAGCCACTGCACGCGGCCCAAGCATTTTTTTTTTTTTAATAGAGAAAGGTCTTGAAAATGGTATATCAAACAGTCCCATTTCTCCCTCAGTCAGAATTGATAATTTATCAACATTTTATATGTACATTTTTAAAAAAATGAATATTATCTCTTCACCAAGACGTTAGGAAAGTTCTTGCCATTCCTAATGGGTTTAGCCATTATTTTGCCCAAAACACTTAGATGTTATAACTTAAAGACTTTCTTGGAGTCAATTCATTTACTTATTCATGGTTGACTATCTCTGATTTTCTTATATTTTGTAATTTAACTTCTCATTCTTTTAGAAATGAAATGGTAGGGAAAAAGAGGAAAATTAAAAATCTCTCTGCTTTTTATTTTTTGCCAACGTTTAAAATTATTGAATAGAAAAAAAAGTTGAGAATTTTTCATATTTTTTTTCATTGCCACACATGAGCAGATAATTGAGTTATAGAGTCAGCTGAGACCTTAAGCAAAGTCATAGTGCTCCTGTAGCTTCAGCCTGGAATCTCCCTGTAGAGCTGGCCTCAGAATACTTGATGGGGAACCCTTTTCTAGGATGAGTGCTATTTATACCTTTCTGGATCTCTTTTTGAGGGTTTATGATTTGCTCCATAATTGAATTACACTCTGTAGTGCATATTGTCATTTACTTGAACTTTCTAAAACCTTCATTTGAGGTTAATTGTAAACCTGTGTACCTTAGGATATGAAGGAGGGTACAGGTTGTTCTTTGTTTCTACTCCATTGAGGTAAGTTGGAGAATGTTAATATTTAATATGTTAGGACAAAAGATTTTTGTTTCTAGTTTTTGTTATGACATCATATTCTTTCATGATAAACAGCCACTGCCTTTGTCCTGTGAGCCATTACAGAAGGCTGTTGTGTTTTGCCTCAGGTAATAGAGTAGGATAGAAAGTAAAAGTTGGGGTTGAGTAATAGGATGATAATGTGTTTTGTTTTCTTTCTCAGTTTCCTTCTGTACTGAACAGTCATGGGCCATTCACTCTGTCTGGGCTGGATGGACCTTCCACCCCTGGCCCATTTTCCCCAGACCTACAGAAGACATAACCTATGCACTTGTGGAATGAGAGAACCGAGGAACGAAGAAACAGACATTCAACATGATTGCATTTGAA Lupus Nephritis 29499937 circHLA-C Plays an Important Role in Lupus Nephritis by Sponging miR-150. Luan J, Jiao C, Kong W, Fu J, Qu W, Chen Y, Zhu X, Zeng Y, Guo G, Qi H, Yao L, Pi J, Wang L, Zhou H. Mol Ther Nucleic Acids. 2018 Significantly upregulated in LN renal biopsies compared with NC kidneys RNA-seq, qRT-PCR lupus nephritis renal biopsies and negtive control kidneys hsa_circ_0000181 circRNA homo sapiens TATDN3 hsa_circ_0000181 hsa_circ_002099 GTTGGACTAGATTTCTCCCCCAGATTTGCTGGCACTGGTGAACAGAAGGAAGAGCAAAGACAAGTCCTAATCAGACAGATCCAGTTAGCCAAAAGACTAAATTTGCCTGTAAATGTGCACTCACGCTCTGCTGGAAGACCTACCATCAACCTTTTACAAGAGCAAGGTGCTGAGAAGGTACTGCTGCATGCATTTGATGGTCGGCCATCTGTAGCCATGGAAGGAGTAAGAGCTGGGTACTTCTTCTCAATTCCCCCTTCTATCATAAGAAGTGGACAG gastric cancer 28940688 Clinical values of circular RNA 0000181 in the screening of gastric cancer. Zhao Q, Chen S, Li T, Xiao B, Zhang X. J Clin Lab Anal. 2017 Hsa_circ_0000181 expression was downregulated in gastric cancer tissues and plasma of patients with gastric cancer. qRT-PCR gastric cancer and paired adjacent non-tumorous tissues and patients¡¯ fasting peripheral plasma The area under the ROC curve (AUC) in tissues was 0.756 (P < .0001). gastric cancer and paired adjacent non-tumorous tissues and patients¡¯ fasting peripheral plasma hsa_circ_0000190 circRNA homo sapiens CNIH4 hsa_circ_0000190 hsa_circ_002125 TGGGTAATTCCAGAATTGATTGGCCATACCATTGTCACTGTATTACTGCTCATGTCATTGCACTGGTTCATCTTCCTTCTCAACTTACCTGTTGCCACTTGGAATATATATCGATACATTATGGTGCCGAGTGGTAACATGGGAGTGTTTGATCCAACAGAAATACACAATCGAGGGCAGCTGAAGTCACACATGAAAGAAGCCATGATCAAGCTTGGTTTCCACTTGCTCTGCTTCTTCATGTATCTTTATAG gastric cancer 28130019 Using circular RNA hsa_circ_0000190 as a new biomarker in the diagnosis of gastric cancer. Chen S, Li T, Zhao Q, Xiao B, Guo J. Clin Chim Acta. 2017 down-regulated in gastric cancer qRT-PCR gastric cancer tissues and adjacent normal tissues, normal plasma samples and patients plasma samples The areas under the ROC curve (AUC) of hsa_circ_0000190 in tissues and plasma were up to 0.75 and 0.60, respectively. gastric cancer tissues and adjacent normal tissues, normal plasma samples and patients plasma samples circFAM188A circRNA homo sapiens FAM188A hsa_circ_0000219 hsa_circ_001349 GGTTTGTGTTTAGTGAATCAGAGGGATCTGCATTAGAACAGTTTGAAGGTGGCCCCTGTGCTGTTATTGCACCTGTTCAGGCATTTCTTTTGAAGAAGCTCCTGTTTTCTTCGGAGAAGTCTTCTTGGCGGGATTGTTCAGAGGAAGAGCAGAAGGAACTCCTTTGTCATACCTTGTGTGATATTTTAGAAAGTGCTTGTTGTGACCACTCTGGATCATACTGCTTGGTTTCATGGTTAAGAGGAAAGACAACTGAGGAAACTGCTAGTATTTCTGGGAGTCCTGCAGAGTCTAGTTGCCAAGTGGAACATTCTTCTGCCTTGGCTGTCGAAGAGCTTGGCTTTGAGCGATTTCATGCATTAATTCAAAAAAGATCGTTCAGAAGTTTACCAGAATTAAAAGATGCTGTCTTGGACCAGTATTCAATGTGGGGAAATAAATTTGGAGTATTGCTTTTTCTGTATTCTGTATTACTGACAAAGGGCATTGAAAACATAAAAAACGAAATTGAAGATGCAAGTGAACCCTTGATAGATCCTGTATATGGACATGGCAGCCAAAGTTTAATTAATCTCCTGCTGACGGGACATGCTGTTTCTAATGTATGGGATGGTGATAGAGAGTGCTCAGGAATGAAACTTCTTGGTATACATGAACAAGCAGCAGTAGGATTTTTAACACTAATGGAAGCTTTAAGATACTGTAAGGTTGGTTCTTACTTGAAATCTCCAAAATTCCCTATTTGGATTGTTGGCAGTGAGACTCACCTCACCGTATTTTTTGCCAAG Lupus Nephritis 29499937 circHLA-C Plays an Important Role in Lupus Nephritis by Sponging miR-150. Luan J, Jiao C, Kong W, Fu J, Qu W, Chen Y, Zhu X, Zeng Y, Guo G, Qi H, Yao L, Pi J, Wang L, Zhou H. Mol Ther Nucleic Acids. 2018 Significantly upregulated in LN renal biopsies compared with NC kidneys RNA-seq, qRT-PCR lupus nephritis renal biopsies and negtive control kidneys hsa_circ_0000257 circRNA homo sapiens NOLC1 hsa_circ_0000257 hsa_circ_000099 ACACAGCAGGATGCCAATGCCTCTTCCCTCTTAGACATCTATAGCTTCTGGCTCAAGTCTGCCAAGGTCCCAGAGCGAAAGTTACAGGCAAATGGACCAGTGGCTAAGAAAGCTAAGAAGAAGGCCTCATCCAGTGACAGTGAGGACAGCAGCGAGGAGGAGGAGGAAGTTCAAGGGCCTCCAGCAAAGAAGGCTGCTGTACCTGCCAAGCGAGTCGGTCTGCCTCCTGGGAAGGCTGCAGCCAAAGCATCAGAGAGTAGCAGCAGTGAAGAGTCCAGTGATGATGATGATGAGGAGGACCAAAAGAAACAGCCTGTCCAGAAGGGAGTTAAGCCCCAAGCCAAGGCAGCCAAAGCTCCTCCTAAGAAGGCCAAGAGCTCTGATTCTGATTCTGACTCAAGCTCCGAGGATGAGCCACCAAAGAACCAGAAGCCAAAGATAACACCTGTGACAGTTAAAGCTCAGACTAAAGCCCCTCCCAAACCAG pancreatic ductal adenocarcinoma 27997903 Circular RNA Expression Profile of Pancreatic Ductal Adenocarcinoma Revealed by Microarray. Li H, Hao X, Wang H, Liu Z, He Y, Pu M, Zhang H, Yu H, Duan J, Qu S. Cell Physiol Biochem. 2016 down microarray, qRT-PCR PDAC samples and corresponding normal tissues circHIPK3 circRNA homo sapiens HIPK3 hsa_circ_0000284 hsa_circ_000016 GTATGGCCTCACAAGTCTTGGTCTACCCACCATATGTTTATCAAACTCAGTCAAGTGCCTTTTGTAGTGTGAAGAAACTCAAAGTAGAGCCAAGCAGTTGTGTATTCCAGGAAAGAAACTATCCACGGACCTATGTGAATGGTAGAAACTTTGGAAATTCTCATCCTCCCACTAAGGGTAGTGCTTTTCAGACAAAGATACCATTTAATAGACCTCGAGGACACAACTTTTCATTGCAGACAAGTGCTGTTGTTTTGAAAAACACTGCAGGTGCTACAAAGGTCATAGCAGCTCAGGCACAGCAAGCTCACGTGCAGGCACCTCAGATTGGGGCGTGGCGAAACAGATTGCATTTCCTAGAAGGCCCCCAGCGATGTGGATTGAAGCGCAAGAGTGAGGAGTTGGATAATCATAGCAGCGCAATGCAGATTGTCGATGAATTGTCCATACTTCCTGCAATGTTGCAAACCAACATGGGAAATCCAGTGACAGTTGTGACAGCTACCACAGGATCAAAACAGAATTGTACCACTGGAGAAGGTGACTATCAGTTAGTACAGCATGAAGTCTTATGCTCCATGAAAAATACTTACGAAGTCCTTGATTTTCTTGGTCGAGGCACGTTTGGCCAGGTAGTTAAATGCTGGAAAAGAGGGACAAATGAAATTGTAGCAATCAAAATTTTGAAGAATCATCCTTCTTATGCCCGTCAAGGTCAAATAGAAGTGAGCATATTAGCAAGGCTCAGTACTGAAAATGCTGATGAATATAACTTTGTACGAGCTTATGAATGCTTTCAGCACCGTAACCATACTTGTTTAGTCTTTGAGATGCTGGAACAAAACTTGTATGACTTTCTGAAACAAAATAAATTTAGTCCCCTGCCACTAAAAGTGATTCGGCCCATTCTTCAACAAGTGGCCACTGCACTGAAAAAATTGAAAAGTCTTGGTTTAATTCATGCTGATCTCAAGCCAGAGAATATTATGTTGGTGGATCCTGTTCGGCAGCCTTACAGGGTTAAAGTAATAGACTTTGGGTCGGCCAGTCATGTATCAAAGACTGTTTGTTCAACATATCTACAATCTCGGTACTACAG Diabetes Mellitus 28860123 Circular Noncoding RNA HIPK3 Mediates Retinal Vascular Dysfunction in Diabetes Mellitus. Shan K, Liu C, Liu BH, Chen X, Dong R, Liu X, Zhang YY, Liu B, Zhang SJ, Wang JJ, Zhang SH, Wu JH, Zhao C, Yan B. Circulation. 2017 circHIPK3 expression was significantly up-regulated in diabetic retinas and retinal endothelial cells following stressors related to diabetes. qRT-PCR, sanger sequencing, northern blots diabetic retinas and retinal endothelial cells circHIPK3 silencing or over-expressing circHIPK3 changed retinal endothelial cell viability, proliferation, migration, and tube formation in vitro. circHIPK3 silencing in vivo alleviated retinal vascular dysfunction, as shown by decreased retinal acellular capillaries, vascular leakage, and inflammation. circHIPK3 acted as an endogenous miR-30a-3p sponge to sequester and inhibit miR-30a-3p activity, which led to increased VEGFC, FZD4, and WNT2 expression. Ectopic expression of miR-30a-3p mimicked the effect of circHIPK3 silencing on vascular endothelial phenotypes in vivo and in vitro. loss of function, gain of function human retinal vascular endothelial cells diabetic mice, PBS-injected mice miR-30a-3p circRNA-miRNA human retinal vascular endothelial cells luciferase reporter assay, AGO2 RIP, RNA pull-down, RNA FISH Three miRNAs (miR-30a-3p, miR-30d-3p, and miR-30e-3p) significantly reduced the activity of LUC-circHIPK3 by at least 37%. RNA-FISH assays revealed a large degree of overlap between circHIPK3 and miR-30a-3p, miR-30d-3p, or miR-30e-3p. Furthermore, using a biotin-coupled miR-30a-3p, miR-30d-3p, and miR-30e-3p, we observed greater enrichment of circHIPK3 in miR-30-captured fraction compared to the negative control, biotinylated miR-335. These results suggest that circHIPK3 serves as a binding platform for Ago2 and miRNAs, and may act as a miRNA sponge. VEGFC, FZD4, and WNT2 c-myb is an upstream regulator of circHIPK3 expression through binding to circHIPK3 promoter. circR-284 circRNA homo sapiens HIPK3 hsa_circ_0000284 hsa_circ_000016 GTATGGCCTCACAAGTCTTGGTCTACCCACCATATGTTTATCAAACTCAGTCAAGTGCCTTTTGTAGTGTGAAGAAACTCAAAGTAGAGCCAAGCAGTTGTGTATTCCAGGAAAGAAACTATCCACGGACCTATGTGAATGGTAGAAACTTTGGAAATTCTCATCCTCCCACTAAGGGTAGTGCTTTTCAGACAAAGATACCATTTAATAGACCTCGAGGACACAACTTTTCATTGCAGACAAGTGCTGTTGTTTTGAAAAACACTGCAGGTGCTACAAAGGTCATAGCAGCTCAGGCACAGCAAGCTCACGTGCAGGCACCTCAGATTGGGGCGTGGCGAAACAGATTGCATTTCCTAGAAGGCCCCCAGCGATGTGGATTGAAGCGCAAGAGTGAGGAGTTGGATAATCATAGCAGCGCAATGCAGATTGTCGATGAATTGTCCATACTTCCTGCAATGTTGCAAACCAACATGGGAAATCCAGTGACAGTTGTGACAGCTACCACAGGATCAAAACAGAATTGTACCACTGGAGAAGGTGACTATCAGTTAGTACAGCATGAAGTCTTATGCTCCATGAAAAATACTTACGAAGTCCTTGATTTTCTTGGTCGAGGCACGTTTGGCCAGGTAGTTAAATGCTGGAAAAGAGGGACAAATGAAATTGTAGCAATCAAAATTTTGAAGAATCATCCTTCTTATGCCCGTCAAGGTCAAATAGAAGTGAGCATATTAGCAAGGCTCAGTACTGAAAATGCTGATGAATATAACTTTGTACGAGCTTATGAATGCTTTCAGCACCGTAACCATACTTGTTTAGTCTTTGAGATGCTGGAACAAAACTTGTATGACTTTCTGAAACAAAATAAATTTAGTCCCCTGCCACTAAAAGTGATTCGGCCCATTCTTCAACAAGTGGCCACTGCACTGAAAAAATTGAAAAGTCTTGGTTTAATTCATGCTGATCTCAAGCCAGAGAATATTATGTTGGTGGATCCTGTTCGGCAGCCTTACAGGGTTAAAGTAATAGACTTTGGGTCGGCCAGTCATGTATCAAAGACTGTTTGTTCAACATATCTACAATCTCGGTACTACAG Carotid Plaque Rupture 28779016 Carotid Plaque Rupture Is Accompanied by an Increase in the Ratio of Serum circR-284 to miR-221 Levels. Bazan HA, Hatfield SA, Brug A, Brooks AJ, Lightell DJ Jr, Woods TC. Circ Cardiovasc Genet. 2017 We confirmed that circR-284 is expressed in human VSMCs and in carotid plaques. Serum circR-284 levels did not exhibit a significant change after an acute carotid plaque rupture-mediated ischemic cerebrovascular event, such as transient ischemic attack or stroke (2.96¡À1.16 versus 1.00¡À0.37; P=0.06). The ratio of serum circR-284:miR-221 was significantly elevated in the urgent group (P=0.0002) and exhibited favorable characteristics as a biomarker indicative of carotid plaque rupture and stroke. A validation study in 112 patients (47 asymptomatic, 41 urgent, and 24 patients with a cerebrovascular event between 5 and 180 days of the carotid endarterectomy [symptomatic]) confirmed elevation of serum circR-284:miR-221. qRT-PCR human VSMCs, carotid plaques miR-221 and miR-222 circRNA-miRNA predicted circR-284 (circbase.org) possesses an miR-221 and miR-222 binding site and may serve to regulate miR-221/miR-222 activity. CircHIPK3 circRNA homo sapiens HIPK3 hsa_circ_0000284 BCRC-2,hsa_circ_000016 GTATGGCCTCACAAGTCTTGGTCTACCCACCATATGTTTATCAAACTCAGTCAAGTGCCTTTTGTAGTGTGAAGAAACTCAAAGTAGAGCCAAGCAGTTGTGTATTCCAGGAAAGAAACTATCCACGGACCTATGTGAATGGTAGAAACTTTGGAAATTCTCATCCTCCCACTAAGGGTAGTGCTTTTCAGACAAAGATACCATTTAATAGACCTCGAGGACACAACTTTTCATTGCAGACAAGTGCTGTTGTTTTGAAAAACACTGCAGGTGCTACAAAGGTCATAGCAGCTCAGGCACAGCAAGCTCACGTGCAGGCACCTCAGATTGGGGCGTGGCGAAACAGATTGCATTTCCTAGAAGGCCCCCAGCGATGTGGATTGAAGCGCAAGAGTGAGGAGTTGGATAATCATAGCAGCGCAATGCAGATTGTCGATGAATTGTCCATACTTCCTGCAATGTTGCAAACCAACATGGGAAATCCAGTGACAGTTGTGACAGCTACCACAGGATCAAAACAGAATTGTACCACTGGAGAAGGTGACTATCAGTTAGTACAGCATGAAGTCTTATGCTCCATGAAAAATACTTACGAAGTCCTTGATTTTCTTGGTCGAGGCACGTTTGGCCAGGTAGTTAAATGCTGGAAAAGAGGGACAAATGAAATTGTAGCAATCAAAATTTTGAAGAATCATCCTTCTTATGCCCGTCAAGGTCAAATAGAAGTGAGCATATTAGCAAGGCTCAGTACTGAAAATGCTGATGAATATAACTTTGTACGAGCTTATGAATGCTTTCAGCACCGTAACCATACTTGTTTAGTCTTTGAGATGCTGGAACAAAACTTGTATGACTTTCTGAAACAAAATAAATTTAGTCCCCTGCCACTAAAAGTGATTCGGCCCATTCTTCAACAAGTGGCCACTGCACTGAAAAAATTGAAAAGTCTTGGTTTAATTCATGCTGATCTCAAGCCAGAGAATATTATGTTGGTGGATCCTGTTCGGCAGCCTTACAGGGTTAAAGTAATAGACTTTGGGTCGGCCAGTCATGTATCAAAGACTGTTTGTTCAACATATCTACAATCTCGGTACTACAG bladder cancer 28794202 CircHIPK3 sponges miR-558 to suppress heparanase expression in bladder cancer cells. Li Y, Zheng F, Xiao X, Xie F, Tao D, Huang C, Liu D, Wang M, Wang L, Zeng F, Jiang G. EMBO Rep. 2017 The expression of circHIPK3 was obviously decreased in 79.5% of the bladder cancer tissues compared with normal bladder tissues and was negatively correlated with bladder cancer grade, invasion, and the lymph nodes metastasis, respectively. Downregulation of circHIPK3 was also found in human muscle-invasive bladder cancer cells T24T and UMUC3 compared with human immortalized uroepithelium cells SV-HUC-1. circHIPK3 is relatively low-expressed in bladder cancer tissues and cell lines, and predominantly localized in cytoplasm. RNA-seq, qRT-PCR, northern blots, FISH bladder cancer tissues, normal bladder tissues, T24T, UMUC3, SV-HUC-1 Over-expression of circHIPK3 effectively inhibits migration, invasion, and angiogenesis of bladder cancer cells in vitro and suppresses bladder cancer growth and metastasis in vivo. Mechanistic studies reveal that circHIPK3 contains two critical binding sites for the microRNA miR-558 and can abundantly sponge miR-558 to suppress the expression of heparanase (HPSE). loss of function, gain of function T24T, UMUC3 female BALB/c nude mice bladder cancer tissues, normal bladder tissues miR-558 circRNA-miRNA T24T and UMUC3 cells RNA pull-down, FISH The above results demonstrate that circHIPK3 can directly bind to miR-558 in T24T and UMUC3 cells. HPSE hsa_circ_0000284 circRNA homo sapiens HIPK3 hsa_circ_0000284 hsa_circ_000016 GTATGGCCTCACAAGTCTTGGTCTACCCACCATATGTTTATCAAACTCAGTCAAGTGCCTTTTGTAGTGTGAAGAAACTCAAAGTAGAGCCAAGCAGTTGTGTATTCCAGGAAAGAAACTATCCACGGACCTATGTGAATGGTAGAAACTTTGGAAATTCTCATCCTCCCACTAAGGGTAGTGCTTTTCAGACAAAGATACCATTTAATAGACCTCGAGGACACAACTTTTCATTGCAGACAAGTGCTGTTGTTTTGAAAAACACTGCAGGTGCTACAAAGGTCATAGCAGCTCAGGCACAGCAAGCTCACGTGCAGGCACCTCAGATTGGGGCGTGGCGAAACAGATTGCATTTCCTAGAAGGCCCCCAGCGATGTGGATTGAAGCGCAAGAGTGAGGAGTTGGATAATCATAGCAGCGCAATGCAGATTGTCGATGAATTGTCCATACTTCCTGCAATGTTGCAAACCAACATGGGAAATCCAGTGACAGTTGTGACAGCTACCACAGGATCAAAACAGAATTGTACCACTGGAGAAGGTGACTATCAGTTAGTACAGCATGAAGTCTTATGCTCCATGAAAAATACTTACGAAGTCCTTGATTTTCTTGGTCGAGGCACGTTTGGCCAGGTAGTTAAATGCTGGAAAAGAGGGACAAATGAAATTGTAGCAATCAAAATTTTGAAGAATCATCCTTCTTATGCCCGTCAAGGTCAAATAGAAGTGAGCATATTAGCAAGGCTCAGTACTGAAAATGCTGATGAATATAACTTTGTACGAGCTTATGAATGCTTTCAGCACCGTAACCATACTTGTTTAGTCTTTGAGATGCTGGAACAAAACTTGTATGACTTTCTGAAACAAAATAAATTTAGTCCCCTGCCACTAAAAGTGATTCGGCCCATTCTTCAACAAGTGGCCACTGCACTGAAAAAATTGAAAAGTCTTGGTTTAATTCATGCTGATCTCAAGCCAGAGAATATTATGTTGGTGGATCCTGTTCGGCAGCCTTACAGGGTTAAAGTAATAGACTTTGGGTCGGCCAGTCATGTATCAAAGACTGTTTGTTCAACATATCTACAATCTCGGTACTACAG 26848835 Circular RNAs Co-Precipitate with Extracellular Vesicles: A Possible Mechanism for circRNA Clearance. Lasda E, Parker R. PLoS One. 2016 detected in preparations enriched in extracellular vesicles RT-PCR, qRT-PCR extracellular vesicles from HeLa, 293T, or U-2 OS cultured cells hsa_circ_0000284 circRNA homo sapiens HIPK3 hsa_circ_0000284 hsa_circ_000016 GTATGGCCTCACAAGTCTTGGTCTACCCACCATATGTTTATCAAACTCAGTCAAGTGCCTTTTGTAGTGTGAAGAAACTCAAAGTAGAGCCAAGCAGTTGTGTATTCCAGGAAAGAAACTATCCACGGACCTATGTGAATGGTAGAAACTTTGGAAATTCTCATCCTCCCACTAAGGGTAGTGCTTTTCAGACAAAGATACCATTTAATAGACCTCGAGGACACAACTTTTCATTGCAGACAAGTGCTGTTGTTTTGAAAAACACTGCAGGTGCTACAAAGGTCATAGCAGCTCAGGCACAGCAAGCTCACGTGCAGGCACCTCAGATTGGGGCGTGGCGAAACAGATTGCATTTCCTAGAAGGCCCCCAGCGATGTGGATTGAAGCGCAAGAGTGAGGAGTTGGATAATCATAGCAGCGCAATGCAGATTGTCGATGAATTGTCCATACTTCCTGCAATGTTGCAAACCAACATGGGAAATCCAGTGACAGTTGTGACAGCTACCACAGGATCAAAACAGAATTGTACCACTGGAGAAGGTGACTATCAGTTAGTACAGCATGAAGTCTTATGCTCCATGAAAAATACTTACGAAGTCCTTGATTTTCTTGGTCGAGGCACGTTTGGCCAGGTAGTTAAATGCTGGAAAAGAGGGACAAATGAAATTGTAGCAATCAAAATTTTGAAGAATCATCCTTCTTATGCCCGTCAAGGTCAAATAGAAGTGAGCATATTAGCAAGGCTCAGTACTGAAAATGCTGATGAATATAACTTTGTACGAGCTTATGAATGCTTTCAGCACCGTAACCATACTTGTTTAGTCTTTGAGATGCTGGAACAAAACTTGTATGACTTTCTGAAACAAAATAAATTTAGTCCCCTGCCACTAAAAGTGATTCGGCCCATTCTTCAACAAGTGGCCACTGCACTGAAAAAATTGAAAAGTCTTGGTTTAATTCATGCTGATCTCAAGCCAGAGAATATTATGTTGGTGGATCCTGTTCGGCAGCCTTACAGGGTTAAAGTAATAGACTTTGGGTCGGCCAGTCATGTATCAAAGACTGTTTGTTCAACATATCTACAATCTCGGTACTACAG 27373735 Screening and validation of lncRNAs and circRNAs as miRNA sponges. Militello G, Weirick T, John D, Döring C, Dimmeler S, Uchida S. Brief Bioinform. 2017 expressed in cytosol RT-PCR HEK293 circHIPK3 circRNA homo sapiens HIPK3 hsa_circ_0000284 hsa_circ_000016 GTATGGCCTCACAAGTCTTGGTCTACCCACCATATGTTTATCAAACTCAGTCAAGTGCCTTTTGTAGTGTGAAGAAACTCAAAGTAGAGCCAAGCAGTTGTGTATTCCAGGAAAGAAACTATCCACGGACCTATGTGAATGGTAGAAACTTTGGAAATTCTCATCCTCCCACTAAGGGTAGTGCTTTTCAGACAAAGATACCATTTAATAGACCTCGAGGACACAACTTTTCATTGCAGACAAGTGCTGTTGTTTTGAAAAACACTGCAGGTGCTACAAAGGTCATAGCAGCTCAGGCACAGCAAGCTCACGTGCAGGCACCTCAGATTGGGGCGTGGCGAAACAGATTGCATTTCCTAGAAGGCCCCCAGCGATGTGGATTGAAGCGCAAGAGTGAGGAGTTGGATAATCATAGCAGCGCAATGCAGATTGTCGATGAATTGTCCATACTTCCTGCAATGTTGCAAACCAACATGGGAAATCCAGTGACAGTTGTGACAGCTACCACAGGATCAAAACAGAATTGTACCACTGGAGAAGGTGACTATCAGTTAGTACAGCATGAAGTCTTATGCTCCATGAAAAATACTTACGAAGTCCTTGATTTTCTTGGTCGAGGCACGTTTGGCCAGGTAGTTAAATGCTGGAAAAGAGGGACAAATGAAATTGTAGCAATCAAAATTTTGAAGAATCATCCTTCTTATGCCCGTCAAGGTCAAATAGAAGTGAGCATATTAGCAAGGCTCAGTACTGAAAATGCTGATGAATATAACTTTGTACGAGCTTATGAATGCTTTCAGCACCGTAACCATACTTGTTTAGTCTTTGAGATGCTGGAACAAAACTTGTATGACTTTCTGAAACAAAATAAATTTAGTCCCCTGCCACTAAAAGTGATTCGGCCCATTCTTCAACAAGTGGCCACTGCACTGAAAAAATTGAAAAGTCTTGGTTTAATTCATGCTGATCTCAAGCCAGAGAATATTATGTTGGTGGATCCTGTTCGGCAGCCTTACAGGGTTAAAGTAATAGACTTTGGGTCGGCCAGTCATGTATCAAAGACTGTTTGTTCAACATATCTACAATCTCGGTACTACAG 28444238 High-purity circular RNA isolation method (RPAD) reveals vast collection of intronic circRNAs. Panda AC, De S, Grammatikakis I, Munk R, Yang X, Piao Y, Dudekula DB, Abdelmohsen K, Gorospe M. Nucleic Acids Res. 2017 circRNA junctions were indeed amplified and verifying the presence of backsplice sites in these transcripts. qRT-PCR HeLa circHIPK3 circRNA homo sapiens HIPK3 hsa_circ_0000284 hsa_circ_000016 GTATGGCCTCACAAGTCTTGGTCTACCCACCATATGTTTATCAAACTCAGTCAAGTGCCTTTTGTAGTGTGAAGAAACTCAAAGTAGAGCCAAGCAGTTGTGTATTCCAGGAAAGAAACTATCCACGGACCTATGTGAATGGTAGAAACTTTGGAAATTCTCATCCTCCCACTAAGGGTAGTGCTTTTCAGACAAAGATACCATTTAATAGACCTCGAGGACACAACTTTTCATTGCAGACAAGTGCTGTTGTTTTGAAAAACACTGCAGGTGCTACAAAGGTCATAGCAGCTCAGGCACAGCAAGCTCACGTGCAGGCACCTCAGATTGGGGCGTGGCGAAACAGATTGCATTTCCTAGAAGGCCCCCAGCGATGTGGATTGAAGCGCAAGAGTGAGGAGTTGGATAATCATAGCAGCGCAATGCAGATTGTCGATGAATTGTCCATACTTCCTGCAATGTTGCAAACCAACATGGGAAATCCAGTGACAGTTGTGACAGCTACCACAGGATCAAAACAGAATTGTACCACTGGAGAAGGTGACTATCAGTTAGTACAGCATGAAGTCTTATGCTCCATGAAAAATACTTACGAAGTCCTTGATTTTCTTGGTCGAGGCACGTTTGGCCAGGTAGTTAAATGCTGGAAAAGAGGGACAAATGAAATTGTAGCAATCAAAATTTTGAAGAATCATCCTTCTTATGCCCGTCAAGGTCAAATAGAAGTGAGCATATTAGCAAGGCTCAGTACTGAAAATGCTGATGAATATAACTTTGTACGAGCTTATGAATGCTTTCAGCACCGTAACCATACTTGTTTAGTCTTTGAGATGCTGGAACAAAACTTGTATGACTTTCTGAAACAAAATAAATTTAGTCCCCTGCCACTAAAAGTGATTCGGCCCATTCTTCAACAAGTGGCCACTGCACTGAAAAAATTGAAAAGTCTTGGTTTAATTCATGCTGATCTCAAGCCAGAGAATATTATGTTGGTGGATCCTGTTCGGCAGCCTTACAGGGTTAAAGTAATAGACTTTGGGTCGGCCAGTCATGTATCAAAGACTGTTTGTTCAACATATCTACAATCTCGGTACTACAG 24039610 Cell-type specific features of circular RNA expression. Salzman J, Chen RE, Olsen MN, Wang PL, Brown PO. PLoS Genet. 2013 HeLa RNA was treated with RNase R or a mock treatment, and then subjected to qPCR with isoform-specific primers. The fraction of linear and circular isoforms was normalized to the value measured in the mock treatment. All tested circular isoforms resisted RNase R. qRT-PCR HeLa circHIPK3 circRNA homo sapiens HIPK3 hsa_circ_0000284 hsa_circ_000016 GTATGGCCTCACAAGTCTTGGTCTACCCACCATATGTTTATCAAACTCAGTCAAGTGCCTTTTGTAGTGTGAAGAAACTCAAAGTAGAGCCAAGCAGTTGTGTATTCCAGGAAAGAAACTATCCACGGACCTATGTGAATGGTAGAAACTTTGGAAATTCTCATCCTCCCACTAAGGGTAGTGCTTTTCAGACAAAGATACCATTTAATAGACCTCGAGGACACAACTTTTCATTGCAGACAAGTGCTGTTGTTTTGAAAAACACTGCAGGTGCTACAAAGGTCATAGCAGCTCAGGCACAGCAAGCTCACGTGCAGGCACCTCAGATTGGGGCGTGGCGAAACAGATTGCATTTCCTAGAAGGCCCCCAGCGATGTGGATTGAAGCGCAAGAGTGAGGAGTTGGATAATCATAGCAGCGCAATGCAGATTGTCGATGAATTGTCCATACTTCCTGCAATGTTGCAAACCAACATGGGAAATCCAGTGACAGTTGTGACAGCTACCACAGGATCAAAACAGAATTGTACCACTGGAGAAGGTGACTATCAGTTAGTACAGCATGAAGTCTTATGCTCCATGAAAAATACTTACGAAGTCCTTGATTTTCTTGGTCGAGGCACGTTTGGCCAGGTAGTTAAATGCTGGAAAAGAGGGACAAATGAAATTGTAGCAATCAAAATTTTGAAGAATCATCCTTCTTATGCCCGTCAAGGTCAAATAGAAGTGAGCATATTAGCAAGGCTCAGTACTGAAAATGCTGATGAATATAACTTTGTACGAGCTTATGAATGCTTTCAGCACCGTAACCATACTTGTTTAGTCTTTGAGATGCTGGAACAAAACTTGTATGACTTTCTGAAACAAAATAAATTTAGTCCCCTGCCACTAAAAGTGATTCGGCCCATTCTTCAACAAGTGGCCACTGCACTGAAAAAATTGAAAAGTCTTGGTTTAATTCATGCTGATCTCAAGCCAGAGAATATTATGTTGGTGGATCCTGTTCGGCAGCCTTACAGGGTTAAAGTAATAGACTTTGGGTCGGCCAGTCATGTATCAAAGACTGTTTGTTCAACATATCTACAATCTCGGTACTACAG 29074849 The circular RNA circBIRC6 participates in the molecular circuitry controlling human pluripotency. Yu CY, Li TC, Wu YY, Yeh CH, Chiang W, Chuang CY, Kuo HC. Nat Commun. 2017 Eenriched in hESCs (>0.1% of GAPDH levels). Downregulated in Ebs, upregulated in induced pluripotent stem cells (iPSCs) as compared with the parental fibroblasts. qRT-PCR Human embryonic stem cells, induced pluripotent stem cells hsa_circ_0000345 circRNA homo sapiens RSF1 hsa_circ_0000345 hsa_circ_001227 AGGAACAGAAAGAAAGTGAAAAGATGAAAAGTGAGGAGCAGCCTATGGATTTAGAAAACCGTTCTACAGCCAATGTTCTAGAAGAGACTACTGTGAAAAAAGAAAAAGAAGATGAAAAGGAACTTGTGAAACTGCCAGTCATAGTGAAGCTAGAAAAACCTTTGCCAGAAAATGAAGAAAAAAAGATTATCAAAGAAGAAAGTGATTCCTTCAAGGAAAATGTCAAACCCATTAAAGTTGAGGTGAAGGAATGTAGAGCAGATCCTAAAGATACCAAAAGTAGCATGGAGAAGCCAGTGGCACAGGAGCCTGAAAGGATCGAATTTGGTGGCAATATTAAATCTTCTCACGAAATTACTGAGAAATCTACTGAAGAAACTGAGAAACTTAAAAATGACCAGCAGGCCAAGATACCACTAAAAAAACGAGAAATTAAACTGAGTGATGATTTTGACAGTCCAGTCAAGGGACCTTTGTGTAAATCAGTTACTCCAACAAAAGAGTTTTTGAAAGATGAAATAAAACAAGAGGAAGAGACTTGTAAAAGGATCTCTACAATCACTGCTTTGGGTCATGAAGGGAAACAGCTGGTAAATGGAGAAGTTAGTGATGAAAGGGTAGCTCCAAATTTTAAGACAGAACCAATAGAGACAAAGTTTTATGAGACAAAGGAAGAGAGCTATAGCCCCTCTAAGGACAGAAATATCATCACGGAGGGAAATGGAACAGAGTCCTTAAATTCTGTCATAACAAGTATGAAAACAGGTGAGCTTGAGAAAGAAACAGCCCCTTTGAGGAAAGATGCAGATAGTTCAATATCAGTCTTAGAGATCCATAGTCAAAAAGCACAAATAGAGGAACCCGATCCTCCAGAAATGGAAACTTCTCTTGATTCTTCTGAGATGGCAAAAGATCTCTCTTCAAAAACTGCTTTATCTTCCACCGAGTCGTGTACCATGAAAGGTGAAGAGAAGTCTCCCAAAACTAAGAAGGATAAGCGCCCACCAATCCTAGAATGTCTTGAAAAGTTAGAGAAGTCCAAAAAGACTTTTCTTGATAAGGACGCACAAAGATTGAGTCCAATACCAGAAGAAGTTCCAAAGAGTACTCTAGAGTCAGAAAAGCCTGGCTCTCCTGAGGCAGCTGAAACTTCTCCACCATCTAATATCATTGACCACTGTGAGAAACTAGCCTCAGAAAAAGAAGTGGTAGAATGCCAGAGTACAAGTACTGTTGGTGGCCAGTCTGTGAAAAAAGTAGACCTAGAAACCCTAAAAGAGGATTCTGAGTTCACAAAGGTAGAAATGGATAATCTGGACAATGCCCAGACCTCTGGCATAGAGGAGCCTTCTGAGACAAAGGGTTCTATGCAAAAAAGCAAATTCAAATATAAGTTGGTTCCTGAAGAAGAAACCACTGCCTCAGAAAATACAGAGATAACCTCTGAAAGGCAGAAAGAGGGCATCAAATTAACAATCAGGATATCAAGTCGGAAAAAGAAGCCCGATTCTCCCCCCAAAGTTCTAGAACCAGAAAACAAGCAAGAGAAGACAGAAAAGGAAGAGGAGAAAACAAATGTGGGTCGTACTTTAAGAAGATCTCCAAGAATATCTAGACCCACTGCAAAAGTGGCTGAGATCAGAGATCAGAAAGCTGATAAAAAAAGAGGGGAAGGAGAAGATGAGGTGGAAGAAGAGTCAACAGCTTTGCAAAAAACTGACAAAAAGGAAATTTTGAAAAAATCAGAGAAAGATACAAATTCTAAAGTAAGCAAGGTAAAACCCAAAGGCAAAGTTCGATGGACTGGTTCTCGGACACGTGGCAGATGGAAATATTCCAGCAATGATGAAAGTGAAGGGTCTGGCAGTGAAAAATCATCTGCAGCTTCAGAAGAGGAGGAAGAAAAGGAAAGTGAAGAAGCCATCCTAGCAGATGATGATGAACCATGCAAAAAATGTGGCCTTCCAAACCATCCTGAGCTA atherosclerosis 28946214 Circular RNA hsa_circ_0003575 regulates oxLDL induced vascular endothelial cells proliferation and angiogenesis. Li CY, Ma L, Yu B. Biomed Pharmacother. 2017 Significantly down-regulated in HUVECs treated with oxLDL compared to HUVECs controls. microarray, qRT-PCR Human umbilical vein endothelial cells hsa_circ_0000414 circRNA homo sapiens IRAK3 hsa_circ_0000414 hsa_circ_001951 CAGAGAGACTTTCAAGCAGCTGGCTGGATGTTCGTCATATTGAAAAGTATGTAGACCAAGGTAAAAGTGGAACAAGAGAATTACTTTGGTCCTGGGCACAGAAAAACAAGACCATCGGTGACCTTTTACAGGTCCTCCAGGAGATGGGACATCGTCGAGCTATTCATTTAATTACAAACTATGGAGCAGTGTTGAGTCCTTCAGAGAAGAGTTATCAGGAAGGTGGATTTCCAAATATATTATTCAAGGAAACAGCCAATGTCACCGTGGATAATGTTCTTATTCCTGAACATAATGAAAAAGGAATACTGCTTAAATCTTCCATCAGCTTTCAAAATATCATAGAAGGAACTAGAAATTTCCACAAAGACTTCCTAATTGGAGAAGGAGAGATTTTTGAGGTATACAGAGTGGAGATTCAAAACCTAACATATGCTGTCAAATTATTTAAACAG Active Pulmonary Tuberculosis 29248507 Potential Diagnostic Power of Blood Circular RNA Expression in Active Pulmonary Tuberculosis. Qian Z, Liu H, Li M, Shi J, Li N, Zhang Y, Zhang X, Lv J, Xie X, Bai Y, Ge Q, Ko EA, Tang H, Wang T, Wang X, Wang Z, Zhou T, Gu W. EBioMedicine. 2018 Upregulated in TB patients compared to healthy controls. RNA-seq, microarray, qRT-PCR healthy controls and TB patients hsa_circ_0000417 circRNA homo sapiens CPSF6 hsa_circ_0000417 hsa_circ_001472 GAAGCTGAATATGGTGGGCATGATCAGATAGATTTGTATGACGATGTCATATCTCCATCTGCAAATAATGGAGATGCCCCAGAAGACCGAGATTACATGGATACTCTCCCACCAACTGTTGGTGATGATGTGGGTAAAGGAGCAGCACCAAATGTTGTCTATACATATACTGGAAAGAGAATTGCATTATATATTGGAAATCTAACATGGTGGACAACAGATGAAGACTTAACTGAAGCAGTTCATTCTTTGGGAGTAAATGATATTTTGGAGATAAAATTTTTTGAAAATCGGGCAAATGGCCAGTCAAAGGGGTTTGCCCTTGTTGGTGTTGGATCTGAAGCATCTTCAAAAAAGTTAATGGATCTGTTACCTAAAAGAGAACTTCATGGTCAGAATCCTGTTGTAACTCCATGCAATAAACAGTTCCTGAGTCAATTTGAAATGCAGTCCAGGAAAACTACACAATCAGGACAAATGTCTGGGGAAGGTAAAGCTGGTCCTCCAGGAGGCAGTTCCCGTGCAGCATTTCCACAAGGTGGTAGAGGACGGGGCCGTTTTCCAGGGGCTGTTCCTGGTGGGGACAGATTTCCTGGGCCAGCAGGACCAGGAGGGCCACCCCCACCTTTTCCAGCTGGACAGACTCCACCACGTCCACCCTTAGGTCCTCCAGGCCCACCTGGTCCACCAGGTCCTCCACCTCCTGGTCAGGTTCTGCCTCCTCCTCTAGCTGGGCCTCCTAATCGAGGAGATCGCCCTCCACCACCAGTTCTTTTTCCTGGACAACCTTTTGGGCAGCCTCCATTGGGTCCACTTCCTCCTGGCCCTCCACCTCCAGTTCCAGGCTACGGCCCCCCTCCTGGCCCACCACCTCCACAACAGGGACCACCTCCACCTCCAGGCCCCTTTCCACCTCGTCCACCCGGTCCACTTGGGCCACCCCTTACACTAGCTCCTCCTCCGCATCTTCCTGGACCACCTCCAGGTGCCCCACCGCCAGCTCCGCATGTGAACCCAGCTTTCTTTCCTCCACCAACTAACAGTGGCATGCCTACATCAGATAGCCGAGGTCCACCACCAACAGATCCATATGGGCGACCTCCACCATATGATAGGGGTGACTATGGCCCCCCTGGAAGGGAAATGGATACTGCAAGAACGCCATTGAGTGAAGCTGAATTTGAAGAAATCATGAATAGAAATAGGGCAATCTCAAGCAGTGCTATTTCGAGAGCTGTGTCTGATGCCAGTGCTGGTGATTATGGGAGTGCTATTGAGACACTGGTAACTGCAATTTCTTTAATTAAACAATCCAAAGTATCTGCTGATGATCGTTGCAAAGTTCTTATTAGTTCTTTGCAAGATTGCCTTCATGGAATTGAGTCCAAGTCTTATGGTTCTGGATCAAGACGTGAACGATCAAGAGAGAGGGACCATAGTAGATCACGAGAAAAGAGTCGACGTCATAAATCCCGTAGTAGAGACCGTCATGACGATTATTACAGAGAGAGAAGCAGAGAACGAGAGAGGCACCGGGATCGTGACCGAGACCGTGACCGAGAGCGTGACCGAGAGCGCGAATATCGTCATCGTTAGAAG male infertile diseases 27958373 Identification and characterization of human testis derived circular RNAs and their existence in seminal plasma. Dong WW, Li HM, Qing XR, Huang DH, Li HG. Sci Rep. 2016 To validate these predicted circRNAs, 55 circRNAs of different abundance and lengths were randomly chosen for subsequent RT-PCR validation. Divergent primers were designed for circRNA detection. Among the 55 circRNAs, 30 of them could be specifically amplified. qRT-PCR human testis circATP2B1 circRNA homo sapiens ATP2B1 hsa_circ_0000426 hsa_circ_000826 ATGTGTATATCTCATGATTGATATGGAGAAACTAGTCATGGGCCAAAGGTCAAGATACTTCTCTGGGAAATGTTGCTGCTGATGCTGCTTTACAAAGTCATACAATGAGTGTTTGGTTTAAGAAAGATTTTCATACTTAAAAGATTTTCATCTTGGAAATACATCAAGTGAAAATTAAATTCTTTTGGGAAACATTTTCCTTCTGATATATTATACTTGTAATGGGCGACATGGCAAACAACTCAGTTGCTTACAGTGGTGTGAAAAACTCTTTGAAGGAAGCTAATCATGATGGAGACTTTGGAATTACGCTCGCAGAGCTGCGGGCTCTCATGGAGCTCAGGTCCACAGATGCATTACGAAAAATACAGGAAAGCTATGGAGATGTCTATGGAATTTGCACCAAATTGAAAACATCTCCCAATGAAGGTTTAAGTGGAAACCCTGCAGATTTAGAAAGAAGAGAAGCAGTGTTTGGAAAGAATTTTATACCTCCTAAAAAGCCAAAAACCTTTCTTCAATTAGTATGGGAAGCATTACAAGATGTCACTTTAATTATATTAGAAATTGCAGCCATAGTATCATTGGGCCTTTCTTTTTATCAGCCTCCAGAAGGGGATAATGCAC clear cell renal cell carcinoma 29490945 ERβ-mediated alteration of circATP2B1 and miR-204-3p signaling promotes invasion of clear cell renal cell carcinoma. Han Z, Zhang Y, Sun Y, Chen J, Chang C, Wang X, Yeh S. Cancer Res. 2018 The expression of circATP2B1 is significantly decreased when ER¦Â was knocked down in 786-O cells, and is significantly increased after over-expressing ER¦Â in A498 cells. qRT-PCR 786-O, A498 ER¦Â/circATP2B1/miR204-3p axis enhanced ccRCC cell invasion via altering the FN1 expression. loss of function, gain of function 786-O, A498, Caki-1, HEK-293 NCr-nu/nu female mice miR-204-3p circRNA-miRNA 786-O, A498 RNA pull-down circATP2B1 can directly interact with miR-204-3p by RNA pull-down assay. FN1 ER¦Â could modulate circATP2B1 expression through regulating its host gene ATP2B1 via direct binding to the estrogen-response-element (-1765nt to -1760nt) on the 5-promoter of ATP2B1. MP_circ_000749 circRNA homo sapiens CORO1C hsa_circ_0000437 hsa_circ_002167 AAAAATATGCAGGAACCAATTGCTCTTCATGAGATGGACACTAGCAATGGGGTGTTGCTGCCTTTCTATGACCCTGACACCAGCATCATTTACTTATGTGGAAAGGGTGACAGCAGTATTCGCTATTTTGAGATCACGGATGAATCCCCGTACGTCCACTACCTCAACACATTCAGCAGCAAGGAGCCTCAGAGAGGGATGGGTTACATGCCCAAGAGGGGACTTGATGTTAACAAATGTGAGATTGCCAG 29089558 A total transcriptome profiling method for plasma-derived extracellular vesicles: applications for liquid biopsies. Amorim MG, Valieris R, Drummond RD, Pizzi MP, Freitas VM, Sinigaglia-Coimbra R, Calin GA, Pasqualini R, Arap W, Silva IT, Dias-Neto E, Nunes DN. Sci Rep. 2017 Detected in extracellular vesicles isolated from the plasma of healthy volunteer individuals participating in the cancer prevention campaign at the ACCCC controls. RNA-seq, qRT-PCR healthy women volunteers circCORO1C circRNA homo sapiens CORO1C hsa_circ_0000437 hsa_circ_002167 AAAAATATGCAGGAACCAATTGCTCTTCATGAGATGGACACTAGCAATGGGGTGTTGCTGCCTTTCTATGACCCTGACACCAGCATCATTTACTTATGTGGAAAGGGTGACAGCAGTATTCGCTATTTTGAGATCACGGATGAATCCCCGTACGTCCACTACCTCAACACATTCAGCAGCAAGGAGCCTCAGAGAGGGATGGGTTACATGCCCAAGAGGGGACTTGATGTTAACAAATGTGAGATTGCCAG 29074849 The circular RNA circBIRC6 participates in the molecular circuitry controlling human pluripotency. Yu CY, Li TC, Wu YY, Yeh CH, Chiang W, Chuang CY, Kuo HC. Nat Commun. 2017 Eenriched in hESCs (>0.1% of GAPDH levels). Downregulated in Ebs, upregulated in induced pluripotent stem cells (iPSCs) as compared with the parental fibroblasts. qRT-PCR Human embryonic stem cells, induced pluripotent stem cells Disrupting circBIRC6 or circCORO1C impairs hESC pluripotency. Expressing circBIRC6 or circCORO1C retains hESC pluripotency. Expressing circBIRC6 or circCORO1C promotes reprogramming. loss of function, gain of function Human embryonic stem cells hsa_circ_0000504 circRNA homo sapiens TUBGCP3 hsa_circ_0000504 hsa_circ_001373 TTTTTTGTAGCATCAGATCCAACAGTTAAAACAGATCGACTGTGGCACGACAAGTATACTTTGAGGAAATCGATGATTCCTTCGTTTATGACGATGGATCAGTCTAGGAAGGTCCTTTTGATAGGAAAATCAATAAATTTCTTGCACCAAGTTTGTCATGATCAGACTCCCACTACAAAGATGATAGCTGTGACCAAGTCTGCAGAGTCACCCCAGGACGCTGCAGACCTATTCACAGACTTGGAAAATGCATTTCAGGGGAAGATTGATGCTGCTTATTTTGAGACCAGCAAATACCTGTTGGATGTTCTCAATAAAAAGTACAGCTTGCTGGACCACATGCAGGCAATGAGGCGGTACCTGCTTCTTGGTCAAGGAGACTTTATAAGGCACTTAATGGACTTGCTAAAACCAGAACTTGTCCGTCCAGCTACGACTTTGTATCAGCATAACTTGACTGGAATTCTAGAAACCGCTGTCAGAGCCACCAACGCACAGTTTGACAGTCCTGAGATCCTGCGAAGGCTGGACGTGCGGCTGCTGGAGGTCTCTCCAGGTGACACTGGATGGGATGTCTTCAGCCTCGATTATCATGTTGACGGACCAATTGCAACTGTGTTTACTCGAGAATGTATGAGCCACTACCTAAGAGTATTTAACTTCCTCTGGAGGGCGAAGCGGATGGAATACATCCTCACTGACATACGGAAGGGACACATGTGCAATGCAAAGCTCCTGAGAAACATGCCAG Colorectal cancer 28656150 Microarray Analysis of Circular RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells. Xiong W, Ai YQ, Li YF, Ye Q, Chen ZT, Qin JY, Liu QY, Wang H, Ju YH, Li WH, Li YF. Biomed Res Int. 2017 up microarray, qRT-PCR CRR (chemoradiation resistance)-HCT116 and the parental HCT116 cells miR-92a-3p, miR-485-5p, miR-641, miR-520a-5p circRNA-miRNA predicted hsa_circRNA_001379 circRNA homo sapiens RPPH1 hsa_circ_0000516 hsa_circ_001379 TCTGACCTCGCGCGGAGCCCCGTTCTCTGGGAACTCACCTCCCCGAAGCTCAGGGAGAGCCCTGTTAGGGCCGCCTCTGGCCCTA papillary thyroid carcinoma 28288173 Microarray profiling of circular RNAs in human papillary thyroid carcinoma. Peng N, Shi L, Zhang Q, Hu Y, Wang N, Ye H. PLoS One. 2017 upregulated microarray, qRT-PCR PTC tumors, matching contralateral normal samples, benign thyroid lesions (i.e., follicular adenoma samples and multinodular goiter samples) hsa-miR-18b-3p, hsa-miR-670-5p, hsa-miR-23a-5p, hsa-miR-125a-3p, hsa-miR-125b-5p circRNA-miRNA predicted hsa_circ_0000520 circRNA homo sapiens RPPH1 hsa_circ_0000520 hsa_circ_001846 GGAAGCTCATCAGTGGGGCCACGAGCTGAGTGCGTCCTGTCACTCCACTCCCATGTCCCTTGGGAAGGTCTGAGACTAGGGCCAGAGGCGGCCCTAACAGGGCTCTCCCTGAGCTTCGGGGAG gastric cancer 29103021 Hsa_circ_0000520, a potential new circular RNA biomarker, is involved in gastric carcinoma. Sun H, Tang W, Rong D, Jin H, Fu K, Zhang W, Liu Z, Cao H, Cao X. Cancer Biomark. 2018 Hsa_circ_0000520 was identified to be significantly down-regulated in gastric cancer microarray, qRT-PCR gastric cancer tissues and corresponding samples, gastric cancer plasma , MKN-45, BGC-823, MGC- 803, AGS, GES-1 The area under the ROC curve (AUC) was 0.6129. gastric cancer tissues hsa_circ_0000567 circRNA homo sapiens SETD3 hsa_circ_0000567 hsa_circ_001983 TCAGAAAAATGGGTAAGAAGAGTCGAGTAAAAACTCAGAAATCTGGCACTGGTGCTACAGCAACTGTGTCACCAAAGGAAATCTTGAACCTGACCAGTGAGCTGCTGCAGAAATGCAGCAGTCCGGCGCCTGGCCCAGGAAAAGAGTGGGAAGAGTATGTGCAGATCCGGACTCTGGTTGAGAAAATACGGAAAAAGCAAAAAGGTCTGTCCGTTACTTTTGATGGAAAAAGAGAAGATTACTTTCCTGATCTAATGAAATGGGCCTCTGAAAATGGGGCTTCTGTCGAGGGTTTTGAAATGGTTAACTTCAAAGAAGAGGGCTTTGGTTTGAGAGCAACAAGAGATATCAAGGCAGAAGAATTGTTTTTATGGGTTCCACGAAAATTGCTAATGACTGTTGAATCTGCTAAAAATTCAGTGTTGGGGCCCTTATATTCTCAAGACCGAATCCTTCAAGCCATGGGAAACATCGCACTGGCCTTTCATTTGCTGTGTGAGCGAGCCAGCCCTAACTCCTTCTGGCAGCCCTATATTCAAACCCTCCCCAGTGAATATGACACTCCTCTCTACTTTGAAGAAGATGAAGTTCGGTATCTTCAGTCCACACAAGCTATACATGATGTCTTCAGCCAGTATAAAAACACAGCTCGACAGTACGCCTACTTCTATAAAGTCATCCAG colorectal cancer 29333615 Circular RNA hsa_circ_0000567 can be used as a promising diagnostic biomarker for human colorectal cancer. Wang J, Li X, Lu L, He L, Hu H, Xu Z. J Clin Lab Anal. 2018 Hsa_circ_0000567 was downregulated in CRC qRT-PCR FHC, SW480, RKO, CACO2, SW620, and HCT116, fresh CRC tissues and adjacent noncancerous tissues Knockdown of hsa_circ_0000567 promoted CRC cells proliferation and migration in vitro. Potential diagnostic value of hsa_circ_0000567 in CRC. loss of function SW480, CACO2 CRC tissues and adjacent noncancerous tissues cZNF609 circRNA homo sapiens ZNF609 hsa_circ_0000615 hsa_circ_000193 CAATGATGTTGTCCACTGGGCATGTACTGACCAATGTGGCAGGTCTGAGAACATAGCTGAAGCTGAAAATAGGAAAGCTGGGGGCAAGGAAGAGCCTTGAATCTTGAGGTGGGACGTTGACTCTAAGATGTCCTTGAGCAGTGGAGCCTCCGGAGGGAAAGGAGTGGATGCAAACCCGGTTGAGACATACGACAGTGGGGATGAATGGGACATTGGAGTAGGGAATCTCATCATTGACCTGGACGCCGATCTGGAAAAGGACCAGCAGAAACTGGAAATGTCAGGCTCAAAGGAGGTGGGGATACCGGCTCCCAATGCTGTGGCCACACTACCAGACAACATCAAGTTTGTGACCCCAGTGCCAGGTCCTCAAGGGAAGGAAGGCAAATCAAAATCCAAAAGGAGTAAGAGTGGCAAAGACACTAGCAAACCCACTCCAGGGACTTCCCTGTTCACTCCAAGTGAGGGGGCAGCTAGCAAGAAAGAGGTGCAGGGGCGCTCAGGAGATGGTGCCAATGCTGGAGGCCTGGTTGCTGCTATTGCTCCCAAGGGCTCAGAGAAGGCGGCTAAGGCATCCCGCAGTGTAGCCGGTTCCAAAAAGGAGAAGGAGAACAGCTCATCTAAGAGCAAGAAGGAGAGAAGCGAAGGAGTGGGGACTTGTTCAGAAAAGGATCCTGGGGTCCTCCAGCCAGTTCCCTTGGGAGGACGGGGTGGTCAGTATGATGGAAGTGCAGGGGTGGATACAGGAGCTGTGGAGCCACTTGGGAGTATAGCTATTGAGCCTGGGGCAGCGCTCAATCCTTTGGGAACTAAACCGGAGCCAGAGGAAGGGGAGAATGAGTGTCGCCTGCTAAAGAAAGTCAAGTCTGAAAAG Vascular Endothelial Dysfunction 28824721 Silencing Of Circular RNA-ZNF609 Ameliorates Vascular Endothelial Dysfunction. Liu C, Yao MD, Li CP, Shan K, Yang H, Wang JJ, Liu B, Li XM, Yao J, Jiang Q, Yan B. Theranostics. 2017 cZNF609 was expressed in several endothelial cells derived from different human vascular beds, including EA.hy.926 cells, HMVECs, HUVECs, RF/6A cells, and HCAECs. qRT-PCRs and fluorescence in situ hybridization (FISH) assays revealed that cZNF609 was mainly expressed in the cytoplasm of HUVECs. HUVECs were exposed to high glucose medium to mimic diabetic condition. High glucose increased cZNF609 expression in a time-dependant manner. cZNF609 expression in diabetic retinas was significantly higher than that in non-diabetic controls. In the mouse model of oxygen-induced retinopathy (OIR), retinal cZNF609 expression was significantly down-regulated at the vaso-obliteration stage (P7-P12), whereas up-regulated at the neovascularization stage (P12-P17). qRT-PCR, FISH EA.hy.926 cells, HMVECs, HUVECs, RF/6A cells, and HCAECs. diabetic retinas cZNF609 silencing decreased retinal vessel loss and suppressed pathological angiogenesis in vivo. cZNF609 silencing increased endothelial cell migration and tube formation, and protected endothelial cell against oxidative stress and hypoxia stress in vitro. By contrast, transgenic overexpression of cZNF609 showed an opposite effects. cZNF609 acted as an endogenous miR-615-5p sponge to sequester and inhibit miR-615-5p activity, which led to increased MEF2A expression. MEF2A overexpression could rescue cZNF609 silencing-mediated effects on endothelial cell migration, tube formation, and apoptosis. Moreover, dysregulated cZNF609 expression was detected in the clinical samples of the patients with diabetes, hypertension, and coronary artery disease. Intervention of cZNF609 expression is promising therapy for vascular dysfunction. loss of function, gain of function endothelial cell Diabetic C57BL/6 mice miR-615-5p circRNA-miRNA HUVECs luciferase reporter assay, RIP cZNF609 serves as a binding platform for Ago2 and miR-615-5p, and may function as a miRNA sponge. MEF2A hsa_circ_0000615 circRNA homo sapiens ZNF610 hsa_circ_0000615 hsa_circ_000193 CAATGATGTTGTCCACTGGGCATGTACTGACCAATGTGGCAGGTCTGAGAACATAGCTGAAGCTGAAAATAGGAAAGCTGGGGGCAAGGAAGAGCCTTGAATCTTGAGGTGGGACGTTGACTCTAAGATGTCCTTGAGCAGTGGAGCCTCCGGAGGGAAAGGAGTGGATGCAAACCCGGTTGAGACATACGACAGTGGGGATGAATGGGACATTGGAGTAGGGAATCTCATCATTGACCTGGACGCCGATCTGGAAAAGGACCAGCAGAAACTGGAAATGTCAGGCTCAAAGGAGGTGGGGATACCGGCTCCCAATGCTGTGGCCACACTACCAGACAACATCAAGTTTGTGACCCCAGTGCCAGGTCCTCAAGGGAAGGAAGGCAAATCAAAATCCAAAAGGAGTAAGAGTGGCAAAGACACTAGCAAACCCACTCCAGGGACTTCCCTGTTCACTCCAAGTGAGGGGGCAGCTAGCAAGAAAGAGGTGCAGGGGCGCTCAGGAGATGGTGCCAATGCTGGAGGCCTGGTTGCTGCTATTGCTCCCAAGGGCTCAGAGAAGGCGGCTAAGGCATCCCGCAGTGTAGCCGGTTCCAAAAAGGAGAAGGAGAACAGCTCATCTAAGAGCAAGAAGGAGAGAAGCGAAGGAGTGGGGACTTGTTCAGAAAAGGATCCTGGGGTCCTCCAGCCAGTTCCCTTGGGAGGACGGGGTGGTCAGTATGATGGAAGTGCAGGGGTGGATACAGGAGCTGTGGAGCCACTTGGGAGTATAGCTATTGAGCCTGGGGCAGCGCTCAATCCTTTGGGAACTAAACCGGAGCCAGAGGAAGGGGAGAATGAGTGTCGCCTGCTAAAGAAAGTCAAGTCTGAAAAG Diabetes Retinopathy 29288268 Identification and Characterization of Circular RNAs as a New Class of Putative Biomarkers in Diabetes Retinopathy. Zhang SJ, Chen X, Li CP, Li XM, Liu C, Liu BH, Shan K, Jiang Q, Zhao C, Yan B. Invest Ophthalmol Vis Sci. 2017 Upregulated in diabetic human retinas compared to nodiabetic retinas. microarray, qRT-PCR diabetic human retinas, nodiabetic retinas Circ-ZNF609 circRNA homo sapiens ZNF609 hsa_circ_0000615 hsa_circ_000193 MSLSSGASGGKGVDANPVETYDSGDEWDIGVGNLIIDLDADLEKDQQKLEMSGSKEVGIPAPNAVATLPDNIKFVTPVPGPQGKEGKSKSKRSKSGKDTSKPTPGTSLFTPSEGAASKKEVQGRSGDGANAGGLVAAIAPKGSEKAAKASRSVAGSKKEKENSSSKSKKERSEGVGTCSEKDPGVLQPVPLGGRGGQYDGSAGVDTGAVEPLGSIAIEPGAALNPLGTKPEPEEGENECRLLKKVKSEKQ CAATGATGTTGTCCACTGGGCATGTACTGACCAATGTGGCAGGTCTGAGAACATAGCTGAAGCTGAAAATAGGAAAGCTGGGGGCAAGGAAGAGCCTTGAATCTTGAGGTGGGACGTTGACTCTAAGATGTCCTTGAGCAGTGGAGCCTCCGGAGGGAAAGGAGTGGATGCAAACCCGGTTGAGACATACGACAGTGGGGATGAATGGGACATTGGAGTAGGGAATCTCATCATTGACCTGGACGCCGATCTGGAAAAGGACCAGCAGAAACTGGAAATGTCAGGCTCAAAGGAGGTGGGGATACCGGCTCCCAATGCTGTGGCCACACTACCAGACAACATCAAGTTTGTGACCCCAGTGCCAGGTCCTCAAGGGAAGGAAGGCAAATCAAAATCCAAAAGGAGTAAGAGTGGCAAAGACACTAGCAAACCCACTCCAGGGACTTCCCTGTTCACTCCAAGTGAGGGGGCAGCTAGCAAGAAAGAGGTGCAGGGGCGCTCAGGAGATGGTGCCAATGCTGGAGGCCTGGTTGCTGCTATTGCTCCCAAGGGCTCAGAGAAGGCGGCTAAGGCATCCCGCAGTGTAGCCGGTTCCAAAAAGGAGAAGGAGAACAGCTCATCTAAGAGCAAGAAGGAGAGAAGCGAAGGAGTGGGGACTTGTTCAGAAAAGGATCCTGGGGTCCTCCAGCCAGTTCCCTTGGGAGGACGGGGTGGTCAGTATGATGGAAGTGCAGGGGTGGATACAGGAGCTGTGGAGCCACTTGGGAGTATAGCTATTGAGCCTGGGGCAGCGCTCAATCCTTTGGGAACTAAACCGGAGCCAGAGGAAGGGGAGAATGAGTGTCGCCTGCTAAAGAAAGTCAAGTCTGAAAAG Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR human myoblasts circ-ZNF609, resulted in specifically controlling myoblast proliferation. Circ-ZNF609 contains an open reading frame spanning from the start codon, in common with the linear transcript, and terminating at an in-frame STOP codon, created upon circularization. Circ-ZNF609 is associated with heavy polysomes, and it is translated into a protein in a splicing-dependent and cap-independent manner, providing an example of a protein-coding circRNA in eukaryotes. loss of function human wild-type (WT) and Duchenne (DMD) myoblasts circZNF609 circRNA homo sapiens ZNF609 hsa_circ_0000615 hsa_circ_000193 CAATGATGTTGTCCACTGGGCATGTACTGACCAATGTGGCAGGTCTGAGAACATAGCTGAAGCTGAAAATAGGAAAGCTGGGGGCAAGGAAGAGCCTTGAATCTTGAGGTGGGACGTTGACTCTAAGATGTCCTTGAGCAGTGGAGCCTCCGGAGGGAAAGGAGTGGATGCAAACCCGGTTGAGACATACGACAGTGGGGATGAATGGGACATTGGAGTAGGGAATCTCATCATTGACCTGGACGCCGATCTGGAAAAGGACCAGCAGAAACTGGAAATGTCAGGCTCAAAGGAGGTGGGGATACCGGCTCCCAATGCTGTGGCCACACTACCAGACAACATCAAGTTTGTGACCCCAGTGCCAGGTCCTCAAGGGAAGGAAGGCAAATCAAAATCCAAAAGGAGTAAGAGTGGCAAAGACACTAGCAAACCCACTCCAGGGACTTCCCTGTTCACTCCAAGTGAGGGGGCAGCTAGCAAGAAAGAGGTGCAGGGGCGCTCAGGAGATGGTGCCAATGCTGGAGGCCTGGTTGCTGCTATTGCTCCCAAGGGCTCAGAGAAGGCGGCTAAGGCATCCCGCAGTGTAGCCGGTTCCAAAAAGGAGAAGGAGAACAGCTCATCTAAGAGCAAGAAGGAGAGAAGCGAAGGAGTGGGGACTTGTTCAGAAAAGGATCCTGGGGTCCTCCAGCCAGTTCCCTTGGGAGGACGGGGTGGTCAGTATGATGGAAGTGCAGGGGTGGATACAGGAGCTGTGGAGCCACTTGGGAGTATAGCTATTGAGCCTGGGGCAGCGCTCAATCCTTTGGGAACTAAACCGGAGCCAGAGGAAGGGGAGAATGAGTGTCGCCTGCTAAAGAAAGTCAAGTCTGAAAAG Lupus Nephritis 29499937 circHLA-C Plays an Important Role in Lupus Nephritis by Sponging miR-150. Luan J, Jiao C, Kong W, Fu J, Qu W, Chen Y, Zhu X, Zeng Y, Guo G, Qi H, Yao L, Pi J, Wang L, Zhou H. Mol Ther Nucleic Acids. 2018 Significantly upregulated in LN renal biopsies compared with NC kidneys RNA-seq, qRT-PCR lupus nephritis renal biopsies and negtive control kidneys MICRA circRNA homo sapiens ZNF609 hsa_circ_0000615 hsa_circ_000193 CAATGATGTTGTCCACTGGGCATGTACTGACCAATGTGGCAGGTCTGAGAACATAGCTGAAGCTGAAAATAGGAAAGCTGGGGGCAAGGAAGAGCCTTGAATCTTGAGGTGGGACGTTGACTCTAAGATGTCCTTGAGCAGTGGAGCCTCCGGAGGGAAAGGAGTGGATGCAAACCCGGTTGAGACATACGACAGTGGGGATGAATGGGACATTGGAGTAGGGAATCTCATCATTGACCTGGACGCCGATCTGGAAAAGGACCAGCAGAAACTGGAAATGTCAGGCTCAAAGGAGGTGGGGATACCGGCTCCCAATGCTGTGGCCACACTACCAGACAACATCAAGTTTGTGACCCCAGTGCCAGGTCCTCAAGGGAAGGAAGGCAAATCAAAATCCAAAAGGAGTAAGAGTGGCAAAGACACTAGCAAACCCACTCCAGGGACTTCCCTGTTCACTCCAAGTGAGGGGGCAGCTAGCAAGAAAGAGGTGCAGGGGCGCTCAGGAGATGGTGCCAATGCTGGAGGCCTGGTTGCTGCTATTGCTCCCAAGGGCTCAGAGAAGGCGGCTAAGGCATCCCGCAGTGTAGCCGGTTCCAAAAAGGAGAAGGAGAACAGCTCATCTAAGAGCAAGAAGGAGAGAAGCGAAGGAGTGGGGACTTGTTCAGAAAAGGATCCTGGGGTCCTCCAGCCAGTTCCCTTGGGAGGACGGGGTGGTCAGTATGATGGAAGTGCAGGGGTGGATACAGGAGCTGTGGAGCCACTTGGGAGTATAGCTATTGAGCCTGGGGCAGCGCTCAATCCTTTGGGAACTAAACCGGAGCCAGAGGAAGGGGAGAATGAGTGTCGCCTGCTAAAGAAAGTCAAGTCTGAAAAG myocardial infarction 29159270 The circular RNA MICRA for risk stratification after myocardial infarction. Salgado-Somoza A, Zhang L, Vausort M, Devaux Y. Int J Cardiol Heart Vasc. 2017 Expression levels of MICRA were lower in patients with rEF compared to patients with mrEF or pEF, and were comparable between patients with mrEF and pEF. qRT-PCR patients with rEF, mrEF or pEF. hsa_circ_0000681 circRNA homo sapiens PRKCB hsa_circ_0000681 hsa_circ_001387 TTTGCTGCTTTGTGGTGCACAAGCGGTGCCATGAATTTGTCACATTCTCCTGCCCTGGCGCTGACAAGGGTCCAGCCTCCGATGACCCCCGCAGCAAACACAAGTTTAAGATCCACACGTACTCCAGCCCCACGTTTTGTGACCACTGTGGGTCACTGCTGTATGGACTCATCCACCAGGGGATGAAATGTGACACCTGCATGATGAATGTGCACAAGCGCTGCGTGATGAATGTTCCCAGCCTGTGTGGCACGGACCACACGGAGCGCCGCGGCCGCATCTACATCCAGGCCCACATCGACAGGGACGTCCTCATTGTCCTCG Active Pulmonary Tuberculosis 29248507 Potential Diagnostic Power of Blood Circular RNA Expression in Active Pulmonary Tuberculosis. Qian Z, Liu H, Li M, Shi J, Li N, Zhang Y, Zhang X, Lv J, Xie X, Bai Y, Ge Q, Ko EA, Tang H, Wang T, Wang X, Wang Z, Zhou T, Gu W. EBioMedicine. 2018 Upregulated in TB patients compared to healthy controls. RNA-seq, microarray, qRT-PCR healthy controls and TB patients circNFATC3 circRNA homo sapiens NFATC3 hsa_circ_0000711 hsa_circ_002176 ATCTTGAGCCAGATGATTGTGCATCCATTTACATCTTTAATGTAGATCCACCTCCATCTACTTTAACCACACCACTTTGCTTACCACATCATGGATTACCGTCTCACTCTTCTGTTTTGTCACCATCGTTTCAGCTCCAAAGTCACAAAAACTATGAAGGAACTTGTGAGATTCCTGAATCTAAATATAGCCCATTAGGTGGTCCCAAACCCTTTGAGTGCCCAAGTATTCAAATTACATCTATCTCTCCTAACTGTCATCAAGAATTAGATGCACATGAAGATGACCTACAGATAAATGACCCAGAACGGGAATTTTTGGAAAGGCCTTCTAGAGATCATCTCTATCTTCCTCTTGAGCCATCCTACCGGGAGTCTTCTCTTAGTCCTAGTCCTGCCAGCAGCATCTCTTCTAGGAGTTGGTTCTCTGATGCATCTTCTTGTGAATCGCTTTCACATATTTATGATGATGTGGACTCAGAGTTGAATGAAGCTGCAGCCCGATTTACCCTTGGATCCCCTCTGACTTCTCCTGGTGGCTCTCCAGGGGGCTGCCCTGGAGAAGAAACTTGGCATCAACAGTATGGACTTGGACACTCATTATCACCCAGGCAATCTCCTTGCCACTCTCCTAGATCCAGTGTCACTGATGAGAATTGGCTGAGCCCCAGGCCAGCCTCAGGACCCTCATCAAGGCCCACATCCCCCTGTGGGAAACGGAGGCACTCCAGTGCTGAAGTTTGTTATGCTGGGTCCCTTTCACCCCATCACTCACCTGTTCCTTCACCTGGTCACTCCCCCAGGGGAAGTGTGACAGAAGATACGTGGCTCAATGCTTCTGTCCATGGTGGGTCAGGCCTTGGCCCTGCAGTTTTTCCATTTCAGTACTGTGTAGAGACTGACATCCCTCTCAAAACAAGGAAAACTTCTGAAGATCAAGCTGCCATACTACCAGGAAAATTAGAGCTGTGTTCAGATGACCAAGGGAGTTTATCACCAGCCCGGGAGACTTCAATAGATGATGGCCTTGGATCTCAGTATCCTTTAAAGAAAGATTCATGTGGTGATCAGTTTCTTTCAGTTCCTTCACCCTTTACCTGGAGCAAACCAAAGCCTGGCCACACCCCTATATTTCGCACATCTTCATTACCTCCACTAGACTGGCCTTTACCAGCTCATTTTGGACAATGTGAACTGAAAATAGAAGTGCAACCTAAAACTCATCATCGAGCCCATTATGAAACTGAAGGTAGCCGAGGGGCAGTAAAAGCATCTACTGGGGGACATCCTGTTGTGAAG 28444238 High-purity circular RNA isolation method (RPAD) reveals vast collection of intronic circRNAs. Panda AC, De S, Grammatikakis I, Munk R, Yang X, Piao Y, Dudekula DB, Abdelmohsen K, Gorospe M. Nucleic Acids Res. 2017 circRNA junctions were indeed amplified and verifying the presence of backsplice sites in these transcripts. qRT-PCR HeLa hsa_circ_0000722 circRNA homo sapiens KIAA0182 hsa_circ_0000722 hsa_circ_000218 GCATGAGCCATGAGCCCAAGTCCCCTTCGCTAGGGATGCTTTCCACCGCGACCAGGACCACCGCCACCGTCAACCCCCTCACCCCCTCGCCGCTCAATGGCGCCCTGGTGCCCAGCGGCAGCCCCGCCACCAGCAGCGCGCTGTCGGCCCAGGCCGCGCCATCCTCCAGCTTTGCCGCCGCGCTGCGCAAGCTCGCCAAACAGGCGGAGGAGCCCAGAG 26848835 Circular RNAs Co-Precipitate with Extracellular Vesicles: A Possible Mechanism for circRNA Clearance. Lasda E, Parker R. PLoS One. 2016 detected in preparations enriched in extracellular vesicles RT-PCR, qRT-PCR extracellular vesicles from HeLa, 293T, or U-2 OS cultured cells hsa_circ_0000732 circRNA homo sapiens SCARF1 hsa_circ_0000732 hsa_circ_000220 GCCAGCGAGAGATGGAGCTACCGTGTCCAGGATGAAGCTGCAGGTCTGGGGGACACTGACCAGCTTGGGCTCCACGCTGCCCTGCCGTTCCCTCAGCTCCCACAAGCTACCCTGGGTGACAGTCTCACATCACGACCCGGAGGTCCCCTTCAACCACAGCTTCATCGAGCCGCCCTCTGCCGGCTGGGCCACTGATGACTCCTTCTCATCCGATCCTGAGTCTGGAGAGGCAGATGAGGTTCCTGCCTACTGTGTGCCACCCCAAGAAG breast cancer 28744405 Circular RNA circ-ABCB10 promotes breast cancer proliferation and progression through sponging miR-1271. Liang HF, Zhang XZ, Liu BG, Jia GT, Li WL. Am J Cancer Res. 2017 up-regulated in breast cancer microarray, qRT-PCR cancer and adjacent noncancerous tissue hsa_circ_0000745 circRNA homo sapiens SPECC1 hsa_circ_0000745 hsa_circ_000013 GGGCCTTTACAACAACTAAACGGACAGGCATTCCAGCCCCACGGGAATTTTCAGTAACTGTCTCAAGAGAGAGGTCTGTGCCACGTGGTCCCTCCAACCCCAGGAAATCAGTGTCCAGTCCAACTTCTTCCAACACTCCCACTCCTACGAAACACCTGAGGACCCCTTCCACAAAGCCCAAGCAAGAGAATGAAGGTGGAGAAAAGGCTGCGCTTGAGTCCCAAGTTCGGGAACTTTTGGCAGAAGCCAAAGCAAAAGATAGTGAAATTAACAGGCTTCGAAGTGAACTAAAGAAATACAAAGAGAAAAGGACTCTGAACGCTGAGGGGACTGATGCTTTGGGCCCAAATGTCGATGGAACATCAGTCTCCCCAGGTGACACGGAACCTATGATAAGAGCTCTTGAGGAGAAGAACAAGAACTTTCAGAAAGAGCTTTCCGATCTAGAGGAAGAAAACCGGGTCCTGAAGGAGAAACTGATCTATCTTGAGCACTCCCCAAATTCAGAAGGGGCAGCAAGTCACACTGGCGACAGCAGCTGCCCAACATCCATAACTCAAGAGTCAAGCTTCGGAAGCCCAACTGGAAATCAGATGTCCAGTGACATTGATGAGTATAAAAAAAACATACATGGAAATGCATTACGGACATCAGGCTCCTCAAGTAGCGATGTTACCAAAGCTTCTTTGTCGCCAGATGCTTCCGACTTTGAGCACATTACAGCAGAGACACCCTCAAGGCCCCTGTCCTCCACCAGTAACCCCTTTAAGAGTTCAAAGTGTTCTACTGCTGGGAGTTCCCCAAACAGCGTAAGTGAATTGTCCCTGGCTTCCCTCACAGAGAAGATACAAAAGATGGAAGAAAACCACCATAGCACTGCAGAAGAACTACAGGCTACTCTACAAGAATTATCAGACCAGCAACAAATGGTACAGGAATTGACAGCTGAAAATGAGAAGCTGGTGGATGAAAAGACGATTTTAGAGACATCCTTTCATCAGCATCGAGAGAGGGCAGAGCAGCTAAGTCAAGAAAATGAGAAGCTGATGAATCTTTTACAAGAGCGAGTAAAGAATGAAGAGCCCACCACTCAGGAAGGAAAAATTATTGAACTGGAGCAGAAGTGCACAGGTATTCTTGAACAGGGCCGCTTTGAAAGAGAGAAGCTACTCAACATTCAGCAGCAGTTGACCTGTAGCTTGCGGAAGGTTGAGGAAGAAAACCAAGGAGCTTTAGAAATGATTAAACGTCTGAAGGAAGAAAATGAAAAACTGAATGAGTTTCTAGAACTGGAACGGCATAATAATAACATGATGGCCAAAACTTTGGAAGAGTGTAGAGTTACCTTGGAAGGGCTAAAAATGGAGAATGGATCTTTGAAGTCTCATTTGCAGGGTGAGAAGCAGAAAGCCACAGAGGCCAGTGCTGTGGAGCAGACGGCAGAGAGCTGCGAAGTTCAAGAAATGTTGAAAGTAGCCCGAGCAGAGAAAGATCTACTGGAACTGTCTTGCAATGAGCTCAGACAAGAATTACTAAAGGCAAACGGTGAAATTAAACATGTTTCCAGTCTGCTGGCCAAG gastric cancer 28974900 Circular RNA hsa_circ_0000745 may serve as a diagnostic marker for gastric cancer. Huang M, He YR, Liang LC, Huang Q, Zhu ZQ. World J Gastroenterol. 2017 down-regulated in GC RNA-seq, qRT-PCR Human samples of GC tissues and paired adjacent non-tumor tissues Potential diagnostic values of hsa_circ_0000745 in GC Human samples of GC tissues and paired adjacent non-tumor tissues circKPNB1 circRNA homo sapiens KPNB1 hsa_circ_0000780 hsa_circ_002147 ATCACAATCGAAGCAATGAAAAGTGACATTGATGAGGTGGCTTTACAAGGGATAGAATTCTGGTCCAATGTCTGTGATGAGGAAATGGATTTGGCCATTGAAGCTTCAGAGGCAGCAGAACAAGGACGGCCCCCTGAGCACACCAGCAAGTTTTATGCGAAGGGAGCACTACAGTATCTGGTTCCAATCCTCACACAGACACTAACTAAACAGGACGAAAATGATGATGACGATGACTGGAACCCCTGCAAAGCAGCAGGGGTGTGCCTCATGCTTCTGGCCACCTGCTGTGAAGATGACATTGTCCCACATGTCCTCCCCTTCATTAAAGAACACATCAAGAACCCAGATTGGCGGTACCGGGATGCAGCAGTGATGGCTTTTGGTTGTATCTTGGAAGGACCAGAGCCCAGTCAGCTCAAACCACTAGTTATACAGGCTATGCCCACCCTAATAGAATTAATGAAAGACCCCAGTGTAGTTGTTCGAGATACAGCTGCATGGACTGTAGGCAGAATTTGTGAGCTGCTTCCTGAAGCTGCCATCAATGATGTCTACTTGGCTCCCCTGCTACAGTGTCTGATTGAGGGTCTCAGTGCTGAACCCAGAGTGGCTTCAAATGTGTGCTGGGCTTTCTCCAGTCTGGCTGAAGCTGCTTATGAAGCTGCAGACGTTGCTGATGATCAGGAAGAACCAGCTACTTACTGCTTATCTTCTTCATTTGAACTCATAGTTCAGAAGCTCCTAGAGACTACAGACAGACCTGATGGACACCAGAACAACCTGAGGAGTTCTGCATATGAATCTCTGATGGAAATTGTGAAAAACAGTGCCAAGGATTGTTATCCTGCTGTCCAGAAAACGACTTTGGTCATCATGGAACGACTGCAACAGGTTCTTCAGATGGAGTCACATATCCAGAGCACATCCGATAGAATCCAGTTCAATGACCTTCAGTCTTTACTCTGTGCAACTCTTCAGAATGTTCTTCGGAAAGTGCAACATCAAGATGCTTTGCAGATCTCTGATGTGGTTATGGCCTCCCTGTTAAGGATGTTCCAAAGCACAGCTGGGTCTGGGGGAGTACAAGAGGATGCCCTGATGGCAGTTAGCACACTGGTGGAAG 29074849 The circular RNA circBIRC6 participates in the molecular circuitry controlling human pluripotency. Yu CY, Li TC, Wu YY, Yeh CH, Chiang W, Chuang CY, Kuo HC. Nat Commun. 2017 Eenriched in hESCs (>0.1% of GAPDH levels). Upregulated in induced pluripotent stem cells (iPSCs) as compared with the parental fibroblasts. qRT-PCR Human embryonic stem cells, induced pluripotent stem cells circBPTF circRNA homo sapiens BPTF hsa_circ_0000799 hsa_circ_001730 GTACAGGTGAACAAAGGCAGAGTAAACTGTCACCCCAGATGCAGGTACATCAAGACAAAACCCTGCCACCAGCTCAGTCATCAAGTGTGGGTCCAGCAGAAGCCCAGCCACAGACTGCTCAGCCTTCAGCTCAGCCCCAGCCCCAAACCCAGCCCCAGTCCCCAGCTCAGCCTGAAGTTCAGACTCAGCCTGAAGTTCAGACCCAAACAACTGTTTCATCCCATGTCCCTTCTGAAGCACAACCCACCCACGCACAGTCATCCAAGCCCCAAGTTGCAGCACAGTCTCAGCCTCAAAGTAATGTCCAAGGACAGTCTCCTGTTCGTGTCCAAAGTCCATCACAGACTCGAATACGTCCATCAACTCCATCCCAACTGTCTCCTGGACAACAATCCCAGGTTCAGACTACAACCTCACAACCGATTCCAATTCAACCACATACATCTCTTCAGATACCTTCCCAAGGCCAGCCACAGTCACAACCCCAGGTACAGTCTTCAACTCAAACTCTTTCATCAGGACAAACTTTAAATCAAGTTACTGTTTCATCCCCATCCCGTCCTCAGCTACAAATACAGCAGCCACAGCCCCAAGTCATTGCTGTGCCTCAGCTGCAACAACAAGTCCAGGTTCTCTCTCAGATCCAGTCACAGGTTGTGGCTCAGATACAGGCTCAGCAAAGTGGTGTGCCCCAGCAAATCAAACTCCAGTTACCTATCCAAATTCAGCAAAGCAGTGCTGTGCAGACTCACCAGATTCAGAATGTGGTTACAGTGCAGGCAGCCAGTGTGCAAGAGCAGTTGCAAAGGGTTCAGCAACTCAGGGATCAGCAGCAAAAGAAGAAACAGCAACAGATAGAAATTAAGCGTGAACACACCCTCCAAGCTTCTAATCAAAGTGAAATCATTCAGAAACAGGTGGTGATGAAGCATAATGCTGTAATAGAACATTTAAAACAGAAAAAGAGCATGACTCCAGCTGAAAGAGAAGAGAATCAAAGAATGATTGTCTGTAACCAGGTGATGAAGTATATTTTGGATAAGATAGATAAAGAAGAAAAACAGGCAGCAAAAAAACGGAAGCGTGAAGAGAGTGTGGAGCAGAAACGTAGCAAGCAGAATGCCACTAAGCTGTCAGCTCTGCTCTTCAAGCACAAAGAGCAGCTCAGAGCCGAGATCCTGAAGAAGAGAGCACTCCTGGACAAGGATCTGCAAATTGAAGTGCAGGAAGAGCTGAAGAGAGACCTGAAAATTAAGAAAGAAAAAGACCTGATGCAGTTGGCTCAGGCCACAGCAGTAGCTGCACCCTGCCCCCCAGTGACACCAGCTCCTCCAGCCCCTCCAGCCCCTCCACCTTCACCTCCCCCTCCACCTGCTGTGCAACACACAGGCCTTCTGTCCACGCCCACCTTACCTGCTGCTTCCCAGAAGAGGAAGCGGGAAGAGGAAAAAGACTCCAGCTCAAAGTCCAAGAAAAAGAAAATGATCTCTACTACCTCAAAGGAAACTAAGAAGGACACAAAGCTTTACTGTATCTGTAAAACGCCTTATGATGAATCTAAATTTTATATTGGCTGTGATCGGTGTCAGAATTGGTACCATGGGCGCTGCGTTGGCATCTTGCAAAGTGAGGCAGAGCTCATTGATGAGTATGTCTGTCCACAGTGCCAGTCAACAGAGGATGCCATGACAGTGCTCACGCCACTAACAGAGAAGGATTATGAGGGGTTGAAGAGGGTGCTCCGTTCCTTACAGGCCCATAAGATGGCCTGGCCTTTCCTTGAACCAGTAGACCCTAATGATGCACCAGATTATTATGGTGTTATTAAGGAACCTATGGACCTTGCCACCATGGAAGAAAGAGTACAAAGACGATATTATGAAAAGCTGACGGAATTTGTGGCAGATATGACCAAAATTTTTGATAACTGTCGTTACTACAATCCAAGTGACTCCCCATTTTACCAGTGTGCAGAAGTTCTCGAATCATTCTTTGTACAGAAATTGAAAGGCTTCAAAGCTAGCAG 28444238 High-purity circular RNA isolation method (RPAD) reveals vast collection of intronic circRNAs. Panda AC, De S, Grammatikakis I, Munk R, Yang X, Piao Y, Dudekula DB, Abdelmohsen K, Gorospe M. Nucleic Acids Res. 2017 circRNA junctions were indeed amplified and verifying the presence of backsplice sites in these transcripts. qRT-PCR HeLa circSMAD2 circRNA homo sapiens SMAD2 hsa_circ_0000847 hsa_circ_000640 GTTCGATACAAGAGGCTGTTTTCCTAGCGTGGCTTGCTGCCTTTGGTAAGAACATGTCGTCCATCTTGCCATTCACGCCGCCAGTTGTGAAGAGACTGCTGGGATGGAAGAAGTCAGCTGGTGGGTCTGGAGGAGCAGGCGGAGGAGAGCAGAATGGGCAGGAAGAAAAGTGGTGTGAGAAAGCAGTGAAAAGTCTGGTGAAGAAGCTAAAGAAAACAGGACGATTAGATGAGCTTGAGAAAGCCATCACCACTCAAAACTGTAATACTAAATGTGTTACCATACCAAGCACTTGCTCTGAAATTTGGGGACTGAGTACACCAAATACGATAGATCAGTGGGATACAACAGGCCTTTACAGCTTCTCTGAACAAACCAGGTCTCTTGATGGTCGTCTCCAGGTATCCCATCGAAAAGGATTGCCACATGTTATATATTGCCGATTATGGCGCTGGCCTGATCTTCACAGTCATCATGAACTCAAGGCAATTGAAAACTGCGAATATGCTTTTAATCTTAAAAAGGATGAAGTATGTGTAAACCCTTACCACTATCAGAGAGTTGAGACACCAGTTTTGCCTCCAGTATTAGTGCCCCGACACACCGAGATCCTAACAGAACTTCCGCCTCTGGATGACTATACTCACTCCATTCCAGAAAACACTAACTTCCCAGCAGGAATTGAGCCACAGAGTAATTATATTCCAGAAACGCCACCTCCTGGATATATCAGTGAAGATGGAGAAACAAGTGACCAACAGTTGAATCAAAGTATGGACACAG 28444238 High-purity circular RNA isolation method (RPAD) reveals vast collection of intronic circRNAs. Panda AC, De S, Grammatikakis I, Munk R, Yang X, Piao Y, Dudekula DB, Abdelmohsen K, Gorospe M. Nucleic Acids Res. 2017 circRNA junctions were indeed amplified and verifying the presence of backsplice sites in these transcripts. qRT-PCR HeLa hsa_circ_001953 circRNA homo sapiens ME2 hsa_circ_0000850 hsa_circ_001953 GTGAAAGAAAAGATGTTGTCCCGGTTAAGAGTAGTTTCCACCACTTGTACTTTGGCATGTCGACATTTGCACATAAAAGAAAAAGGCAAGCCACTTATGCTGAACCCAAGAACAAACAAGGGAATGGCATTTACTTTACAAGAACGACAAATGCTTGGTCTTCAAGGACTTCTACCTCCCAAAATAGAGACACAAGATATTCAAGCCTTACGATTTCATAGAAACTTGAAGAAAATGACTAGCCCTTTGGAAAAATATATCTACATAATGGGAATACAAGAAAGAAATGAGAAATTGTTTTATAGAATACTGCAAGATGACATTGAGAGTTTAATGCCAATTGTATATACACCGACGGTTGGTCTTGCCTGCTCCCAGTATGGACACATCTTTAGAAGACCTAAGGGATTATTTATTTCGATCTCAGACAGAGGTCATGTTAGATCAATTGTGGATAACTGGCCAGAAAATCATGTTAAGGCTGTTGTAGTGACTGATGGAGAGAGAATTCTGGGTCTTGGAGATCTGGGTGTCTATGGAATGGGAATTCCAGTAGGAAAACTTTGTTTGTATACAGCTTGTGCAGGAATACGGCCTGATAGATGCCTGCCAGTGTGTATTGATGTGGGAACTGATAATATCGCACTCTTAAAAGACCCATTTTACATGGGCTTGTACCAGAAACGAGATCGCACACAACAGTATGATGACCTGATTGATGAGTTTATGAAAGCTATTACTGACAGATATGGCCGGAACACACTCATTCAGTTCGAAGACTTTGGAAATCATAATGCATTCAGGTTCTTGAGAAAGTACCGAGAAAAATATTGTACTTTCAATGATGATATTCAAGGGACAGCTGCAGTAGCTCTAGCAGGTCTTCTTGCAGCACAAAAAGTTATTAGTAAACCAATCTCCGAACACAAAATCTTATTCCTTGGAGCAGGAGAGGCTGCTCTTGGAATTGCAAATCTTATAGTTATGTCTATGGTAGAAAATGGCCTGTCAGAACAAGAGGCACAAAAGAAAATCTGGATGTTTGACAAGTATGGTTTATTAGTTAAGGGACGGAAAGCAAAAATAGATAGTTATCAGGAACCATTTACTCACTCAGCCCCAGAGAGCATACCTGATACTTTTGAAGATGCAGTGAATATACTGAAGCCTTCAACTATAATTGGAGTTGCAGGTGCTGGCCGTCTTTTCACTCCTGATGTAATCAGAGCCATGGCCTCTATCAATGAAAGGCCTGTAATATTTGCATTAAGTAATCCTACAGCACAGGCAGAGTGCACGGCTGAAGAAGCATATACACTTACAGAG clear cell renal cell carcinoma 29490945 ERβ-mediated alteration of circATP2B1 and miR-204-3p signaling promotes invasion of clear cell renal cell carcinoma. Han Z, Zhang Y, Sun Y, Chen J, Chang C, Wang X, Yeh S. Cancer Res. 2018 The expression of hsa_circ_001953 is significantly decreased when ER¦Â was knocked down in 786-O cells qRT-PCR 786-O - - hsa_circ_0000893 circRNA homo sapiens DHPS hsa_circ_0000893 hsa_circ_000261 ATCGAGAAGAAGCTGGAACCACTGTCACAGGATGAAGACCAGCACGCGGACCTGACCCAGAGCCGCCGCCCACTTACCAGCTGCACCATTTTCCTGGGATATACATCCAACCTCATCAGTTCAGGCATCCGTGAGACCATTCGCTACCTTGTGCAGCACAACATGGTGGACGTATTGGTGACCACAGCTGGCGGCGTGGAGGAAGACCTCATCAAGTGCCTGGCGCCCACATACTTGGGCGAGTTTAGCCTCAGGGGGAAGGAGCTCCGGGAGAACGGGATCAATAGGATCGGAAACCTGCTGGTGCCCAATGAGAATTACTGCAAGTTTGAGGACTGGCTGATGCCCATTCTGGACCAGATGGTGATGGAGCAGAACACAGAGGGTGTAAAGTGGACGCCTTCTAAGATGATCGCCCGGCTGGGCAAGGAGATCAACAACCCAGAGTCCGTGTATTACTGGGCCCAGAAG breast cancer 28744405 Circular RNA circ-ABCB10 promotes breast cancer proliferation and progression through sponging miR-1271. Liang HF, Zhang XZ, Liu BG, Jia GT, Li WL. Am J Cancer Res. 2017 down-regulated in breast cancer microarray, qRT-PCR cancer and adjacent noncancerous tissue circMYO9B circRNA homo sapiens MYO9B hsa_circ_0000907 hsa_circ_000265 CTCCAGGACACGCGCGCCCCGAGCCTGGGAGGCATGCTGAAGCCAGGCGGCCGGCAGGATGAGTGTGAAAGAGGCAGGCAGCTCGGGCCGCCGGGAGCAGGCGGCCTACCACCTGCACATCTACCCCCAGCTGTCCACCACCGAGAGCCAGGCCTCGTGCCGCGTGACTGCCACCAAGGACAGCACCACCTCGGACGTCATCAAGGACGCCATTGCCAGCCTGCGGCTGGACGGCACCAAATGTTATGTGCTGGTGGAGGTCAAAGAGTCGGGAGGCGAGGAATGGGTGCTGGACGCCAACGACTCGCCTGTGCACCGGGTGCTGCTATGGCCCCGGCGGGCACAGGACGAGCACCCTCAGGAGGATGGCTACTACTTCCTGCTGCAGGAGCGCAACGCAGATGGAACCATCAAGTACGTGCATATGCAGCTGGTGGCGCAGGCCACAGCCACCCGGCGCCTAGTGGAGCGTGGCCTCCTGCCACGGCAGCAGGCGGACTTTGATGACCTGTGTAACCTCCCCGAGCTAACCGAGGGCAACCTCCTGAAGAACCTCAAGCACCGCTTCCTGCAACAAAAGATCTACACGTACGCGGGGAGCATCCTGGTGGCCATCAACCCCTTTAAGTTCCTGCCCATCTACAACCCCAAGTACGTGAAGATGTATGAGAACCAGCAGCTGGGCAAGCTGGAGCCACACGTCTTCGCGCTGGCCGACGTGGCCTACTACACCATGCTCAGGAAGCGCGTGAACCAGTGCATCGTGATCTCGGGTGAGAGCGGCTCCGGCAAGACCCAGAGCACCAACTTCCTCATCCACTGCCTCACCGCCCTCAGCCAGAAGGGCTACGCCAGCGGCGTCGAGAGGACCATCCTGGGTGCTGGCCCTGTGCTGGAG 29074849 The circular RNA circBIRC6 participates in the molecular circuitry controlling human pluripotency. Yu CY, Li TC, Wu YY, Yeh CH, Chiang W, Chuang CY, Kuo HC. Nat Commun. 2017 Eenriched in hESCs (>0.1% of GAPDH levels). Downregulated in Ebs, upregulated in induced pluripotent stem cells (iPSCs) as compared with the parental fibroblasts. qRT-PCR Human embryonic stem cells, induced pluripotent stem cells hsa_circ_0000911 circRNA homo sapiens GTPBP3 hsa_circ_0000911 hsa_circ_000268 CTGCCTGAGGGCCTGCCGCCGCTGCGCCTCTGTTTCCGCGTGGATAAGGTCCGCCAGCCCCTCCACTTCGGTCAGGTTCAGCTTCCCATTGGCGAACGCCCGTCTGGTGAACTCGCCTGCCTCCGCCGGTCGAAGCCCTGGCACGCTGCCTGCAGGAAGGTCCCAGTCTGACACCCCCTGGTCCCCACCCAGGCCCATTGGGAGGACCAAGCATCTCACCCAACGCTGCAACTCACCCAAGGCCTGCAGGACGCCGCTCACCACTGCCGGGCCTCCATGCACGTGGAACTCCACGCAGTCCTCACCGGTGAAACTCTGGGGACCTAATGTGACAGACAGGTGACAGGAGGACAGCACAGCCAGTGCAAACCCTTGGAAGGGGGAAACTGAGTCATGGGACCTACAGGAGGCTCGGAACCTGGGGACCCTCACCTGGGAACCAGAGCACCAGTGCGCGGTCCAGAGGCTCCCCGGAGCGGGGATCGCTGAGCAGGCGCAGGCTGGCGTGGCGAGCAAGGGGCAGGTCTCGGG breast cancer 28744405 Circular RNA circ-ABCB10 promotes breast cancer proliferation and progression through sponging miR-1271. Liang HF, Zhang XZ, Liu BG, Jia GT, Li WL. Am J Cancer Res. 2017 down-regulated in breast cancer microarray, qRT-PCR cancer and adjacent noncancerous tissue circFKBP8 circRNA homo sapiens FKBP8 hsa_circ_0000915 hsa_circ_000271 GGAACGGGCTGTTGAGGAAGAAGACGCTGGTCCCAGGGCCGCCAGGTTCGAGCCGCCCGGTCAAGGGCCAGGTGGTCACCGTACATCTGCAGACGTCGCTGGAGAATGGCACACGGGTGCAGGAGGAGCCGGAGCTGGTGTTCACTCTGGGTGACTGTGACGTCATCCAGGCCCTGGATCTCAGTGTCCCACTCATGGACGTGGGGGAGACGGCCATGGTCACTGCTGACTCCAAGTACTGCTACGGCCCCCAAGGCAG 29074849 The circular RNA circBIRC6 participates in the molecular circuitry controlling human pluripotency. Yu CY, Li TC, Wu YY, Yeh CH, Chiang W, Chuang CY, Kuo HC. Nat Commun. 2017 Eenriched in hESCs (>0.1% of GAPDH levels). Downregulated in Ebs, upregulated in induced pluripotent stem cells (iPSCs) as compared with the parental fibroblasts. qRT-PCR Human embryonic stem cells, induced pluripotent stem cells circRNA-chr19 circRNA homo sapiens ZNF536 hsa_circ_0000922 hsa_circ_000648 GTGAGAAACCCTACAAGTGTCCGCACTGTGACTATGCCGGCACGCAGTCAGCATCCTTAAAATACCACTTAGAGCGACACCATCGGGAGCGGCAGAACGGGGCTGGGCCGCTGTCTGGGCAACCCCCAAATCAAGACCACAAGGATGAGATGTCAAGCAAAGCTTCTCTGTTCATCAGGCCAGACATCCTGAGGGGGGCCTTCAAGGGTCTCCCTGGAATCGACTTCAGAGGAGGCCCTGCATCTCAGCAGTGGACATCAGGGGTTCTCTCCTCTGGAGATCACTCGGGGCAGGCCACGGGCATGTCTTCGGAGGTCCCCTCAGATGCTCTGAAAGGCACTGACCTTCCTTCCAAAAGCACCCACTTCTCTGAGATCGGAAGAGCTTATCAAAGCATTGTGAGCAACGGTGTGAATTTCCAAGGGTCCTTGCAAGCTTTCATGGACAGTTTTGTCCTCAGTTCCTTGAAGAAGGAGAAGGACATGAAGGACAAAGCCCTGGCTGACCCCCCTTCCATGAAAGTCCACGGAGTGGATGGTGGTGAGGAGAAACCCAGTGGCAAGTCCTCCCAGAGGAAGTCCGAGAAATCTCAGTATGAACCCCTGGACTTGTCTGTGCGGCCAGATGCCGCCTCCCTCCCGGGCTCCTCGGTAACTGTGCAGGACAGCATTGCATGGCACGGCTGCTTGTTTTGTGCTTTCACAACGTCCTCCATGGAGCTCATGGCCCTTCATCTCCAGGCCAACCACCTGGGCAAAGCGAAACGCAAAGATAACACCATCGGGGTCACAGTCAACTGCAAAGACCAAGCCCGGGAGGCGAGTAAGATGGCCCTGCTGCCCTCGTTACAATCAAACAAAGACCTGGGCCTCTCCAATATGATCAGCTCTCTAGACTCTGCTTCTGAGAAGATGGCCCAAGGTCAGCTCAAGGAGACTCTGGGAGAGCAGAAGAGCGGTGCATGGACCGGCCACGTGGACCCTGCATTTTGTAACTTCCCATCAGACTTCTACAAGCAGTTTGGTGTTTACCCAGGCATGGTTGGCTCAGGGGCCTCCAGTTCCTGCCCCAACAAGGAGCCTGATGGAAAGGCCCACTCTGAAGAGGATGTCCCCATCCTGATCCCCGAAACCACGAGTAAGAACACTACTGATGACCTCTCTGACATTGCCTCCTCAGAGGACATGGACTCCTCCAAGGGGGAGAACAACGATGAAGAGGATGTTGAAACCGAACCGGAAATGATGACCAAGCCACTGTCTGCCCTCAGCAAAGACAGCAGCAGCGATGGCGGGGACAGCCTGCAGCCCACAGGCACCTCCCAGCCCGTCCAGGGACTGGTCTCACCTTTATCCCAAGCACCGGAGAAGCAGTGGCACAGCCAGGGTCTTCTCCAAGCCCAGGACCCCTTGGCGGGCCTGCCAAAGCCGGAGCGGGGGCCCCAGAGCCTGGACAAGCCGATGAACATGCTGTCGGTCCTCAGGGCCTACAGTTCTGATGGCTTAGCAGCCTTTAACGGACTTGCAAGTAGCACAGCAAATTCTGGATGTATCAAGAGGCCAGACTTGTGTG Ebola virus 29209594 Genome-Wide Search for Competing Endogenous RNAs Responsible for the Effects Induced by Ebola Virus Replication and Transcription Using a trVLP System. Wang ZY, Guo ZD, Li JM, Zhao ZZ, Fu YY, Zhang CM, Zhang Y, Liu LN, Qian J, Liu LN. Front Cell Infect Microbiol. 2017 CircRNA-chr19 expression in 293T cells was up-regulated post virus infection. qRT-PCR 293T cells miR-30b-3p circRNA-miRNA 293T cells predicted miR-30b-3p is a potential target for CLDN18 and may also be regulated by circRNA-chr19. CLDN18 hsa_circ_0000977 circRNA homo sapiens NOL10 hsa_circ_0000977 hsa_circ_001918 TTCTGAAGTTTATAGGTTAAACTTAGAACAAGGACGATACCTGAATCCTCTACAAACTGATGCTGCGGAGAATAATGTTTGTGACATAAATTCAGTGCATGGCTTGTTTGCCACAGGAACCATAGAGGGTAGAGTGGAGTGCTGGGACCCAAGAACTCGAAACAGAGTTGGCCTGTTAGACTGCGCCTTAAACAGTGTCACAGCAGATTCAGAGATAAACAGTTTACCAACAATCTCTGCTTTGAAATTTAATGGTGCCTTGACCATGGCAGTTGGAACAACCACAGGGCAGGTTTTATTATATGACCTTCGATCTGATAAGCCATTGCTAGTTAAAGATCACCAGTATGGGCTGCCCATTAAGTCCGTTCATTTCCAGGATTCATTAGATCTGATTTTGTCTGCTGACTCTCGAATTGTCAAGATGTGGAATAAGAACTCCGGAAAAATATTTACTTCCTTGGAGCCAGAGCATGACCTTAATGATGTTTGTCTCTACCCCAACTCAGGCATGCTTCTGACGGCCAATGAAACCCCCAAGATGGGCATCTATTACATTCCA pancreatic ductal adenocarcinoma 29454093 Silencing circular RNA hsa_circ_0000977 suppresses pancreatic ductal adenocarcinoma progression by stimulating miR-874-3p and inhibiting PLK1 expression. Huang WJ, Wang Y, Liu S, Yang J, Guo SX, Wang L, Wang H, Fan YF. Cancer Lett. 2018 upregulated microarray, qRT-PCR AsPC-1 and PANC-1, matched PDAC and adjacent non-cancerous tissues Overexpression of hsa_circ_0000977 is correlated with poor prognosis in PDAC patients. hsa_circ_0000977 regulates cell proliferation and cell cycle by sequestering miR-874-3P in vitro. Knockdown of hsa_circ_0000977 inhibits pancreatic cell growth in vivo. gain of function AsPC-1 and PANC-1 Five-week-old female BALB/c nude mice PDAC and adjacent non-cancerous tissues miR-874-3p circRNA-miRNA HEK293T, AsPC-1 and PANC-1 luciferase reporter assay, RNA FISH There was significant reduction of firefly luciferase reporter activity for transfected hsa-miR-874-3p and hsa-circ-0000977 WT, and there was no notable change of luciferase reporter activity in the hsa-circ-0000977 mutant. The co-localization of hsa-circ-0000977 and miR-874-3p in pancreatic cancer cells by FISH. PLK1 hsa_circ_0000981 circRNA homo sapiens LAPTM4A hsa_circ_0000981 hsa_circ_001506 GTAGTCTCCCACTATTTTATATCTTTGTTACTTCAAGTAAGACAATCTTAAATATGAGAGGACATCTAGAGATTGTGCTAAGATTGCGTCGTGATG breast cancer 28744405 Circular RNA circ-ABCB10 promotes breast cancer proliferation and progression through sponging miR-1271. Liang HF, Zhang XZ, Liu BG, Jia GT, Li WL. Am J Cancer Res. 2017 down-regulated in breast cancer microarray, qRT-PCR cancer and adjacent noncancerous tissue circBIRC6 circRNA homo sapiens BIRC6 hsa_circ_0000989 hsa_circ_002146 CTAAACCAGGTGGACAGGTGAAATGTCAGTATATCTCTGCTGTGGATAAAGTTATATTTGTGGATGATTATGCAGTAGGGTGTAGGAAGGACCTTAATGGAATCTTGTTGTTAGACACTGCTCTGCAAACTCCAGTTTCAAAGCAGGATGATGTGGTTCAGCTTGAATTACCCGTTACAGAGGCACAGCAGCTCTTATCAGCATGTTTAGAAAAGGTAGATATTTCTAGTACAGAGGGTTATGATTTGTTCATCACACAGCTCAAAGATGGTTTAAAAAATACATCTCATGAGACTGCAGCAAACCACAAAGTTGCTAAGTGGGCCACAGTTACATTTCATCTTCCTCATCATGTGTTGAAGTCCATTGCCAGTGCCATTGTAAATGAACTCAAGAAAATAAATCAAAATGTTGCTGCCTTACCTGTGGCGTCCTCAGTGATGGACAGATTGTCTTACCTCTTACCTAGTGCACGTCCAGAACTCGGAGTGGGGCCAGGCCGTTCTGTAGACAGATCACTGATGTATAGTGAAGCTAACAGACGGGAGACATTTACCTCATGGCCTCATGTAGGCTATAGGTGGGCACAACCAGATCCCATGGCTCAAGCTGGATTTTATCATCAGCCTGCCTCATCTGGAGATGATAGAGCCATGTGTTTTACTTGTAGTGTATGCCTCGTTTGTTGGGAACCTACTGATGAACCTTGGTCTGAACACGAAAGACATTCCCCAAACTGCCCATTTGTGAAAGGTGAGCACACACAGAATGTGCCATTGTCAGTCACTCTTGCAACAAGTCCTGCACAGTTTCCTTGTACGGATGGAACTGACAGAATATCTTGCTTTGGGTCGGGGAGCTGCCCTCATTTTCTAGCTGCTGCAACTAAACGAGGAAAGATCTGCATATGGGATGTTTCCAAACTTATGAAGGTGCACTTAAAGTTTGAAATTAATGCCTATGATCCAGCAATTGTACAACAGCTTATTCTATCAGGAGACCCAAGCTCAGGAGTTGATTCAAGGAGACCAACTTTGGCGTGGCTGGAGGACTCCTCTAGTTGCTCAGATATACCAAAATTGGAAGGAGATAGTGATGATTTACTGGAGGATTCAGACAGTGAAGAGCATTCCAGATCAGATTCTGTGACAG 29074849 The circular RNA circBIRC6 participates in the molecular circuitry controlling human pluripotency. Yu CY, Li TC, Wu YY, Yeh CH, Chiang W, Chuang CY, Kuo HC. Nat Commun. 2017 Eenriched in hESCs (>0.1% of GAPDH levels). Downregulated in Ebs, upregulated in induced pluripotent stem cells (iPSCs) as compared with the parental fibroblasts. qRT-PCR Human embryonic stem cells, induced pluripotent stem cells Disrupting circBIRC6 or circCORO1C impairs hESC pluripotency. Expressing circBIRC6 or circCORO1C retains hESC pluripotency. Expressing circBIRC6 or circCORO1C promotes reprogramming. CircBIRC6 acts as a sponge for miR-34a and miR-145 in hESCs. loss of function, gain of function Human embryonic stem cells miR-34a, miR-145 circRNA-miRNA Human embryonic stem cells qRT-PCR, luciferase reporter assays, northern blots circBIRC6 may exert its function through direct interactions with miR-34a and miR-145. miR-34a target genes (MDM4 and SIRT1) and miR-145 target genes (ADAM17 and NEDD9) ESRP1 promotes the generation of circBIRC6 in hESCs. hsa_circ_0001017 circRNA homo sapiens XPO1 hsa_circ_0001017 hsa_circ_002020 TAATCTATGCCAGCAATTATGACAATGTTAGCAGACCATGCAGCTCGTCAGCTGCTTGATTTCAGCCAAAAACTGGATATCAACTTATTAGATAATGTGGTGAATTGCTTATACCATGGAGAAGGAGCCCAGCAAAGAATGGCTCAAGAAGTACTGACACATTTAAAGGAGCATCCTGATGCTTGGACAAGAGTCGACACAATTTTGGAATTTTCTCAGAATATGAATACGAAATACTATGGACTACAAATTTTGGAAAATGTGATAAAAACAAGGTGGAAGATTCTTCCAAGGAACCAGTGCGAAG Gastric cancer 29098316 Plasma circular RNA profiling of patients with gastric cancer and their droplet digital RT-PCR detection. Li T, Shao Y, Fu L, Xie Y, Zhu L, Sun W, Yu R, Xiao B, Guo J. J Mol Med (Berl). 2018 down microarray, RT-ddPCR gastric cancer tissues and their adjacent non-tumorous tissues, and gastric cancer patients¡¯ plasma and healthy controls, BGC-823, MGC-803, SGC-7901 and GES-1 Hsa_circ_0001017 and hsa_circ_0061276 can be prognostic indicators of gastric cancer. gastric cancer tissues and their adjacent non-tumorous tissues, and gastric cancer patients¡¯ plasma and healthy controls circUGP2 circRNA homo sapiens UGP2 hsa_circ_0001020 hsa_circ_001739 ATCTTAGCAAAGCAATGTCTCAAGATGGTGCTTCTCAGTTCCAAGAAGTCATTCGGCAAGAGCTAGAATTATCTGTGAAGAAGGAACTAGAAAAAATACTCACCACAGCATCATCACATGAATTTGAGCACACCAAAAAAGACCTGGATGGATTTCGGAAGCTATTTCATAGATTTTTGCAAGAAAAGGGGCCTTCTGTGGATTGGGGAAAAATCCAGAGACCCCCTGAAGATTCG 28444238 High-purity circular RNA isolation method (RPAD) reveals vast collection of intronic circRNAs. Panda AC, De S, Grammatikakis I, Munk R, Yang X, Piao Y, Dudekula DB, Abdelmohsen K, Gorospe M. Nucleic Acids Res. 2017 circRNA junctions were indeed amplified and verifying the presence of backsplice sites in these transcripts. qRT-PCR HeLa circILKAP circRNA homo sapiens ILKAP hsa_circ_0001116 hsa_circ_002163 TACTCGGGTTTCATATTTTGCTGTTTTTGATGGACATGGAGGAATTCGAGCCTCAAAATTTGCTGCACAGAATTTGCATCAAAACTTAATCAGAAAATTTCCTAAAGGAGATGTAATCAGTGTAGAGAAAACCGTGAAGAGATGCCTTTTGGACACTTTCAAGCATACTGATGAAGAGTTCCTTAAACAAGCTTCCAGCCAGAAGCCTGCCTGGAAAGATGGGTCCACTGCCACGTGTGTTCTGGCTGTAGACAACATTCTTTATATTGCCAACCTCGGAGATAGTCGGGCAATCTTGTGTCGTTATAATGAGGAGAGTCAAAAACATGCAGCCTTAAGCCTCAGCAAAGAGCATAATCCAACTCAGTATGAAGAGCGGATGAGGATACAGAAGGCTGGAGGAAACGTCAG 29074849 The circular RNA circBIRC6 participates in the molecular circuitry controlling human pluripotency. Yu CY, Li TC, Wu YY, Yeh CH, Chiang W, Chuang CY, Kuo HC. Nat Commun. 2017 Eenriched in hESCs (>0.1% of GAPDH levels). Upregulated in induced pluripotent stem cells (iPSCs) as compared with the parental fibroblasts. qRT-PCR Human embryonic stem cells, induced pluripotent stem cells hsa_circ_0001136 circRNA homo sapiens ASXL1 hsa_circ_0001136 hsa_circ_002158 GTATTAGAAAACTACTCGGATGCTCCAATGACACCAAAACAGATTCTGCAGGTCATAGAGGCAGAAGGACTAAAGGAAATGAGCAGTGGGACTTCCCCTCTCGCATGCCTCAATGCTATGCTACATTCCAATTCAAGAGGAGGAGAGGGGTTGTTTTATAAACTGCCTGGCCGAATCAGCCTTTTCACGCTCAAG 26848835 Circular RNAs Co-Precipitate with Extracellular Vesicles: A Possible Mechanism for circRNA Clearance. Lasda E, Parker R. PLoS One. 2016 detected in preparations enriched in extracellular vesicles RT-PCR, qRT-PCR extracellular vesicles from HeLa, 293T, or U-2 OS cultured cells circASXL1 circRNA homo sapiens ASXL1 hsa_circ_0001136 hsa_circ_002158 GTATTAGAAAACTACTCGGATGCTCCAATGACACCAAAACAGATTCTGCAGGTCATAGAGGCAGAAGGACTAAAGGAAATGAGCAGTGGGACTTCCCCTCTCGCATGCCTCAATGCTATGCTACATTCCAATTCAAGAGGAGGAGAGGGGTTGTTTTATAAACTGCCTGGCCGAATCAGCCTTTTCACGCTCAAG 28444238 High-purity circular RNA isolation method (RPAD) reveals vast collection of intronic circRNAs. Panda AC, De S, Grammatikakis I, Munk R, Yang X, Piao Y, Dudekula DB, Abdelmohsen K, Gorospe M. Nucleic Acids Res. 2017 circRNA junctions were indeed amplified and verifying the presence of backsplice sites in these transcripts. qRT-PCR HeLa circ-ASXL1 circRNA homo sapiens ASXL1 hsa_circ_0001136 hsa_circ_002158 GTATTAGAAAACTACTCGGATGCTCCAATGACACCAAAACAGATTCTGCAGGTCATAGAGGCAGAAGGACTAAAGGAAATGAGCAGTGGGACTTCCCCTCTCGCATGCCTCAATGCTATGCTACATTCCAATTCAAGAGGAGGAGAGGGGTTGTTTTATAAACTGCCTGGCCGAATCAGCCTTTTCACGCTCAAG 27736885 Dynamic ASXL1 Exon Skipping and Alternative Circular Splicing in Single Human Cells. Koh W, Gonzalez V, Natarajan S, Carter R, Brown PO, Gawad C. PLoS One. 2016 first confirmed the presence of the ASXL1 circular isoformthat is composed of exons 2 and 3 using RNAse R RT-PCR, sequencing HeLa hsa_circ_0001189 circRNA homo sapiens MORC3 hsa_circ_0001189 hsa_circ_001502 ATGATTAATTTAGCAGAATCAAAAGCCAGCCTTGCTGCAATTCTGGAACATTCTCTGTTTTCCACGGAACAGAAGTTACTGGCAGAACTTGATGCTATTATAGGCAAGAAGGGGACGAGGATCATCATTTGGAATCTTAGAAGCTACAAAAATGCAACAGAGTTCGATTTTGAAAAGGATAAATATGATATCAGAATTCCCGAGGATTTAGATGAGATAACAGGGAAGAAGGGGTACAAGAAGCAGGAAAGGATGGACCAGATTGCCCCTGAGAGTGACTATTCCCTGAGGGCTTATTGCAGTATATTATATCTAAAGCCAAGAATGCAGATCATCCTACGTGGACAGAAAGTGAAGACACAGCTGGTTTCGAAGAGTCTTGCCTACATCGAACGTGATGTTTATCGACCAAAATTTTTA hypopharyngeal squamous cell carcinoma 28514762 Novel circular RNA expression profiles reflect progression of patients with hypopharyngeal squamous cell carcinoma. Cao S, Wei D, Li X, Zhou J, Li W, Qian Y, Wang Z, Li G, Pan X, Lei D. Oncotarget. 2017 down microarray, qRT-PCR Tumor tissues and paired adjacent normal tissues hsa_circ_0001283 circRNA homo sapiens WDR48 hsa_circ_0001283 hsa_circ_000939 TAATATCTGCTTCTTCTGACACGACAGTAAAAGTATGGAATGCACACAAGGGATTTTGCATGTCAACATTAAGGACACATAAGGATTACGTAAAGGCCTTAGCATATGCCAAGGATAAAGAACTAGTAGCATCAGCTGGGTTGGACAGACAAATATTCCTTTGGGATGTGAATACTCTAACAGCATTGACTGCCTCAAATAACACTGTCACAACTTCTTCTTTAAGTGGAAACAAAGATTCCATTTATAGCCTGGCCATGAATCAACTGGGAACAATCATTGTATCAGGGTCCACTGAAAAGGTGTTACGGGTATGGGATCCAAGAACATGTGCAAAACTAATGAAGCTTAAAGGGCACACGGATAATGTGAAGGCATTGCTATTAAACAGAGATGGCACGCAATGCCTGTCAGGCAGTTCTGATGGGACAATTCGCCTTTGGTCCCTTGGCCAGCAGAGATGTATAGCAACATACCGAGTCCATGATGAAGGTGTTTGGGCGCTGCAAGTCAATGATGCCTTCACACATGTGTATTCTGGTGGAAGGGACAGGAAGATTTATTGTACAGACCTAAGAAACCCTGACATTCGGGTGCTAATTTGTGAAGAAAAAGCACCAGTTCTCAAGATGGAGCTTGATAGATCAGCTGATCCTCCTCCTGCAATTTGGGTTGCAACAACTAAGTCTACAGTAAATAAATGGACTTTGAAAGGAATTCATAATTTTAGAGCCTCTGGAGATTATGACAATGACTGTACAAATCCTATAACACCTCTTTGTACACAACCTGACCAGGTTATTAAAGGGGGTGCTAGTATTATTCAGTGCCACATTCTTAATGATAAGAGACATATATTAACCAAAGATACCAATAATAATGTGGCATATTGGGATGTATTGAAGGCATGTAAAGTTGAAGATCTGGGCAAAGTGGATTTTGAAGATGAAATTAAGAAAAGATTTAAAATGGTGTATGTGCCAAATTGGTTCTCAGTAGACTTAAAAACAGGGATGTTAACTATTACTTTGGATGAAAGTGATTGTTTTGCTGCCTGGGTTTCTGCAAAAGATGCTGGTTTCAGCAGCCCTGATGGGTCAGATCCAAAATTGAATTTAGGAGGACTTTTACTCCAAGCACTCCTGGAATATTGGCCTAGAACACATGTGAATCCAATGGATGAAGAGGAAAATGAAGTAAACCATGTAAATGGGGAGCAGGAGAACCGAGTGCAGAAGGGAAATGGATATTTTCAAGTGCCCCCACATACACCCGTGATCTTTGGTGAAGCTGGAGGTCGCACACTGTTCAGGCTGCTCTGCCGAGATTCCGGGGGTGAGACTGAGTCTATGCTTCTTAATGAAACAGTGCCACAATGGGTAATTGACATCACTGTGGAT breast cancer 28744405 Circular RNA circ-ABCB10 promotes breast cancer proliferation and progression through sponging miR-1271. Liang HF, Zhang XZ, Liu BG, Jia GT, Li WL. Am J Cancer Res. 2017 down-regulated in breast cancer microarray, qRT-PCR cancer and adjacent noncancerous tissue circCCDC66 circRNA homo sapiens CCDC66 hsa_circ_0001313 hsa_circ_000374 GAAACAGTACTGCTGGAGCACCCTTTCAGTGCTGTGAAACAAGAACTGCAAAGAAAATGGATTGAAGAGTTGAATAAGCAAATAGAAGATGACCGTCAAAGAAAAATAGAGGAAAAAATTATATATTCAAAGGGTGAGGAACATGACAGATGGGCAATGCACTTTGATTCATTAAAGAGTTATCCTGGTTCTCAATCTCAGCTGTTCTCTCAGTCAACACACAAACAACCTGAGTACTTCTGTGTCTCTCCTGACACTCAGGAGCTGGCTGATGTCAGCAGTGTTTGTACACCTACAACCGGAAGCCAGGTTGAACCTTCAGAGGAGGAGCATATAGCAAAACCTATTAAGGATGTGGTTATGGCAAACAGTAAGAAAACAAACTTTCTCCGTTCTATGACTGCTCTCTTGGACCCAGCTCAGATTGAGGAACGAGACAGACGACGACAAAAACAATTAGAGCATCAG Colorectal Cancer 28249903 Noncoding Effects of Circular RNA CCDC66 Promote Colon Cancer Growth and Metastasis. Hsiao KY, Lin YC, Gupta SK, Chang N, Yen L, Sun HS, Tsai SJ. Cancer Res. 2017 CircCCDC66 expression was elevated in polyps and colon cancer RNA-seq, qRT-PCR polyps, colon cancer circCCDC66 controlled multiple pathological processes, including cell proliferation, migration, invasion, and anchorage-independent growth. In-depth characterization revealed that circCCDC66 exerts its function via regulation of a subset of oncogenes, and knockdown of circCCDC66 inhibited tumor growth and cancer invasion in xenograft and orthotopic mouse models, respectively. loss of function, gain of function, mouse model HCT116, HT-29, 3T3L1 colon tumor/adjacent nontumor specimens hsa_circRNA_103636 circRNA homo sapiens DCUN1D4 hsa_circ_0001410 hsa_circ_000947 ATTTTCAGCTGAACTCTCATCTCTCAACACTGGCAAATATTCATAAGATCTACCACACCCTTAATAAGCTGAACCTAACAGAAGACATTGGCCAAGACGATCACCAAACAGGAAGTCTGCGGTCTTGCAGTTCTTCAGACTGCTTTAATAAAGTGATGCCACCAAGGAAAAAGAGAAGACCTGCCTCTGGAGATGATTTATCTGCCAAGAAAAGTAGACATGATAGCATGTATAGAAAATATGATTCGACTAGAATAAAGACTGAAGAAGAAGCCTTTTCAAGTAAAAGGTGCTTGGAATGGTTCTATGAATATGCAG Major depressive disorder 27404501 hsa_circRNA_103636: potential novel diagnostic and therapeutic biomarker in Major depressive disorder. Cui X, Niu W, Kong L, He M, Jiang K, Chen S, Zhong A, Li W, Lu J, Zhang L. Biomark Med. 2016 down-regulated hsa_circRNA_103636 was significantly altered after the 8-week treatment in MDD patients qRT-PCR MDD patients hsa_circ_0001417 circRNA homo sapiens ANKRD17 hsa_circ_0001417 hsa_circ_001160 GGGTGGCACTGAATCAACAAGACAAGCAACTCAATTGATTAATGCTTTGATCAAGGATCCAGACAAAGAAATTGATGAACTTATTCCAAAGAATCGTTTGAAAAGCTCCTCAGCAAATTCCAAAATAGGGTCATCAGCACCTACCACCACTGCTGCTAACACTTCCTTAATGGGAATTAAAATGACAACTGTAGCTCTGTCATCAACATCTCAAACTGCCACAGCACTCACTGTGCCTGCAATTTCTTCTGCATCCACTCACAAAACCATTAAGAACCCAGTGAATAATGTGAGGCCTGGTTTTCCAGTTTCTCTTCCATTAGCATATCCTCCTCCACAGTTTGCACATGCTTTGCTTGCTGCTCAGACTTTCCAGCAGATCCGTCCACCAAGGTTGCCCATGACCCACTTTGGAGGTACTTTTCCACCAGCTCAATCCACTTGGGGTCCGTTTCCTGTCAGGCCTTTGAGCCCTGCCAGAGCTACTAACTCGCCTAAGCCTCACATGGTGCCTCGCCATAGCAATCAGAATAGCAGTGGTTCTCAGGTGAATTCAGCAGGTTCTTTAACTTCAAGCCCAACAACTACAACCAGTTCATCAGCTTCAACGGTGCCTGGTACATCTACAAATGGCAGTCCAAGTTCACCTTCTGTCCGAAGGCAGCTTTTTGTCACAGTTGTGAAGACATCCAATGCCACCACAACAACAGTCACAACCACGGCAAGCAACAACAACACTGCACCCACAAATGCCACATATCCTATGCCTACTGCCAAAGAACACTATCCAGTATCATCCCCATCTTCCCCATCACCACCAGCCCAGCCAGGAGGGGTTTCTAGAAACAGCCCTTTGGATTGTGGATCAGCATCTCCAAATAAAGTGGCATCTTCCTCCGAACAGGAAGCAGGTAGTCCACCAGTAGTAGAAACAACAAACACTAGACCTCCAAACAGCAGCAGTTCTTCTGGGAGTTCATCAGCTCATTCTAATCAGCAACAACCTCCGGGATCTGTTTCTCAGGAACCAAGACCACCTCTTCAGCAGTCTCAGGTTCCTCCCCCGGAAGTTAGAATGACTGTTCCTCCTTTAGCAACAAGTTCTGCTCCAGTGGCGGTGCCTTCTACTGCCCCAGTGACTTACCCTATGCCTCAGACACCAATGGGATGCCCCCAGCCTACTCCTAAAATGGAAACCCCTGCTATTAGACCACCCCCTCATGGCACAACTGCCCCTCACAAGAATTCAGCTTCAGTGCAAAATTCATCTGTTGCAGTCCTCAGTGTCAATCACATTAAAAGACCTCACAGTGTTCCCTCTTCTGTCCAGCTACCTTCGACCTTAAGTACACAAAGTGCTTGTCAGAATTCAGTACATCCAGCAAATAAGCCTATTGCTCCCAATTTCAGTGCCCCCTTACCATTTGGGCCCTTTAGCACATTGTTTGAAAACAGCCCTACTTCTGCTCATGCCTTCTGGGGAGGATCTGTTGTTTCATCTCAGTCAACACCAGAATCTATGCTATCAGGAAAATCCTCATATTTGCCAAATTCAGATCCTTTACATCAGTCTGATACTTCCAAAGCTCCAGGTTTTAGACCACCATTACAGAGACCTGCTCCAAGTCCCTCAGGTATTGTCAATATGGACTCGCCATATGGTTCTGTAACACCTTCTTCAACACATTTGGGAAACTTTGCTTCAAACATTTCAGGAGGTCAGATGTACGGACCTGGGGCACCCCTTGGAGGAGCACCCGCAGCTGCTAACTTTAACAGACAACATTTTTCCCCGCTTAGTTTGTTGACTCCGTGTTCATCAGCATCAAATG 27373735 Screening and validation of lncRNAs and circRNAs as miRNA sponges. Militello G, Weirick T, John D, Döring C, Dimmeler S, Uchida S. Brief Bioinform. 2017 expressed in cytosol RT-PCR HEK293 circANKRD17 circRNA homo sapiens ANKRD17 hsa_circ_0001417 hsa_circ_001160 GGGTGGCACTGAATCAACAAGACAAGCAACTCAATTGATTAATGCTTTGATCAAGGATCCAGACAAAGAAATTGATGAACTTATTCCAAAGAATCGTTTGAAAAGCTCCTCAGCAAATTCCAAAATAGGGTCATCAGCACCTACCACCACTGCTGCTAACACTTCCTTAATGGGAATTAAAATGACAACTGTAGCTCTGTCATCAACATCTCAAACTGCCACAGCACTCACTGTGCCTGCAATTTCTTCTGCATCCACTCACAAAACCATTAAGAACCCAGTGAATAATGTGAGGCCTGGTTTTCCAGTTTCTCTTCCATTAGCATATCCTCCTCCACAGTTTGCACATGCTTTGCTTGCTGCTCAGACTTTCCAGCAGATCCGTCCACCAAGGTTGCCCATGACCCACTTTGGAGGTACTTTTCCACCAGCTCAATCCACTTGGGGTCCGTTTCCTGTCAGGCCTTTGAGCCCTGCCAGAGCTACTAACTCGCCTAAGCCTCACATGGTGCCTCGCCATAGCAATCAGAATAGCAGTGGTTCTCAGGTGAATTCAGCAGGTTCTTTAACTTCAAGCCCAACAACTACAACCAGTTCATCAGCTTCAACGGTGCCTGGTACATCTACAAATGGCAGTCCAAGTTCACCTTCTGTCCGAAGGCAGCTTTTTGTCACAGTTGTGAAGACATCCAATGCCACCACAACAACAGTCACAACCACGGCAAGCAACAACAACACTGCACCCACAAATGCCACATATCCTATGCCTACTGCCAAAGAACACTATCCAGTATCATCCCCATCTTCCCCATCACCACCAGCCCAGCCAGGAGGGGTTTCTAGAAACAGCCCTTTGGATTGTGGATCAGCATCTCCAAATAAAGTGGCATCTTCCTCCGAACAGGAAGCAGGTAGTCCACCAGTAGTAGAAACAACAAACACTAGACCTCCAAACAGCAGCAGTTCTTCTGGGAGTTCATCAGCTCATTCTAATCAGCAACAACCTCCGGGATCTGTTTCTCAGGAACCAAGACCACCTCTTCAGCAGTCTCAGGTTCCTCCCCCGGAAGTTAGAATGACTGTTCCTCCTTTAGCAACAAGTTCTGCTCCAGTGGCGGTGCCTTCTACTGCCCCAGTGACTTACCCTATGCCTCAGACACCAATGGGATGCCCCCAGCCTACTCCTAAAATGGAAACCCCTGCTATTAGACCACCCCCTCATGGCACAACTGCCCCTCACAAGAATTCAGCTTCAGTGCAAAATTCATCTGTTGCAGTCCTCAGTGTCAATCACATTAAAAGACCTCACAGTGTTCCCTCTTCTGTCCAGCTACCTTCGACCTTAAGTACACAAAGTGCTTGTCAGAATTCAGTACATCCAGCAAATAAGCCTATTGCTCCCAATTTCAGTGCCCCCTTACCATTTGGGCCCTTTAGCACATTGTTTGAAAACAGCCCTACTTCTGCTCATGCCTTCTGGGGAGGATCTGTTGTTTCATCTCAGTCAACACCAGAATCTATGCTATCAGGAAAATCCTCATATTTGCCAAATTCAGATCCTTTACATCAGTCTGATACTTCCAAAGCTCCAGGTTTTAGACCACCATTACAGAGACCTGCTCCAAGTCCCTCAGGTATTGTCAATATGGACTCGCCATATGGTTCTGTAACACCTTCTTCAACACATTTGGGAAACTTTGCTTCAAACATTTCAGGAGGTCAGATGTACGGACCTGGGGCACCCCTTGGAGGAGCACCCGCAGCTGCTAACTTTAACAGACAACATTTTTCCCCGCTTAGTTTGTTGACTCCGTGTTCATCAGCATCAAATG 28444238 High-purity circular RNA isolation method (RPAD) reveals vast collection of intronic circRNAs. Panda AC, De S, Grammatikakis I, Munk R, Yang X, Piao Y, Dudekula DB, Abdelmohsen K, Gorospe M. Nucleic Acids Res. 2017 circRNA junctions were indeed amplified and verifying the presence of backsplice sites in these transcripts. qRT-PCR HeLa cSMARCA5 circRNA homo sapiens SMARCA5 hsa_circ_0001445 hsa_circ_000003 GGAGGCTTGTGGATCAGAATCTGAACAAAATTGGGAAAGATGAAATGCTTCAAATGATTAGACATGGAGCAACACATGTGTTTGCTTCAAAGGAAAGTGAGATCACTGATGAAGATATCGATGGTATTTTGGAAAGAGGTGCAAAGAAGACTGCAGAGATGAATGAAAAGCTCTCCAAGATGGGCGAAAGTTCACTTAGAAACTTTACAATGGATACAGAGTCAAGTGTTTATAACTTCGAAGGAGAAGACTATAGAGAAAAACAAAAG hepatocellular carcinoma 29378234 Circular RNA cSMARCA5 inhibits growth and metastasis in hepatocellular carcinoma. Yu J, Xu QG, Wang ZG, Yang Y, Zhang L, Ma JZ, Sun SH, Yang F, Zhou WP. J Hepatol. 2018 Circular RNA cSMARCA5 was downregulated in HCC. The expression of endogenous cSMARCA5 was the lowest in HCCLM3; moderate in Hep3B, MHCC97H and SMMC-7721; and the highest in Huh7. RNA-seq, northern blots, qRT-PCR pairs of HCC and corresponding adjacent noncancerous liver tissues. HCCLM3, Hep3B, MHCC97H, SMMC-7721, Huh7 cSMARCA5 inhibited HCC growth and metastasis both in vitro and in vivo. Down-regulated cSMARCA5 expression predicts aggressive clinicopathological characteristics and poor prognosis in HCC patients after hepatectomy. gain of function, loss of function SMMC-7721, Huh7 and HCCLM3 5 weeks old male BALB/c nude mice pairs of HCC and corresponding adjacent noncancerous liver tissues miR-17-3p, miR-181b-5p circRNA-miRNA SMMC-7721, Huh7, HEK293T AGO2 RIP, circRIP, luciferase reporter assay, RNA pull-down, RNA FISH All these experiments proved that cSMARCA5 may function as a sponge for miR-17-3p and miR-181b-5p. TIMP3 cSMARCA5 was upregulated upon knocking down DHX9 using shRNA hsa_circ_0001445 circRNA homo sapiens SMARCA5 hsa_circ_0001445 hsa_circ_000003 GGAGGCTTGTGGATCAGAATCTGAACAAAATTGGGAAAGATGAAATGCTTCAAATGATTAGACATGGAGCAACACATGTGTTTGCTTCAAAGGAAAGTGAGATCACTGATGAAGATATCGATGGTATTTTGGAAAGAGGTGCAAAGAAGACTGCAGAGATGAATGAAAAGCTCTCCAAGATGGGCGAAAGTTCACTTAGAAACTTTACAATGGATACAGAGTCAAGTGTTTATAACTTCGAAGGAGAAGACTATAGAGAAAAACAAAAG male infertile diseases 27958373 Identification and characterization of human testis derived circular RNAs and their existence in seminal plasma. Dong WW, Li HM, Qing XR, Huang DH, Li HG. Sci Rep. 2016 To validate these predicted circRNAs, 55 circRNAs of different abundance and lengths were randomly chosen for subsequent RT-PCR validation. Divergent primers were designed for circRNA detection. Among the 55 circRNAs, 30 of them could be specifically amplified. qRT-PCR human testis circFAT1 circRNA homo sapiens FAT1 hsa_circ_0001461 hsa_circ_000713 ATTCCCGACAGTTAAGCAATGGGGAGACATTTGGCTTTGCTCCTGCTTCTGCTCCTTCTCTTCCAACATTTTGGAGACAGTGATGGCAGCCAACGACTTGAACAGACTCCTCTGCAGTTTACACACCTCGAGTACAACGTCACCGTGCAGGAGAACTCTGCAGCTAAGACTTATGTGGGGCATCCTGTCAAGATGGGTGTTTACATTACACATCCAGCGTGGGAAGTAAGGTACAAAATTGTTTCCGGAGACAGTGAAAACCTGTTCAAAGCTGAAGAGTACATTCTCGGAGACTTTTGCTTTCTAAGAATAAGGACCAAAGGAGGAAATACAGCTATTCTTAATAGAGAAGTGAAGGATCACTACACATTGATAGTGAAAGCACTTGAAAAAAATACTAATGTGGAGGCGCGAACAAAGGTCAGGGTGCAGGTGCTGGATACAAATGACTTGAGACCGTTATTCTCACCCACCTCATACAGCGTTTCTTTACCTGAAAACACAGCTATAAGGACCAGTATCGCAAGAGTCAGCGCCACGGATGCAGACATAGGAACCAACGGGGAATTTTACTACAGTTTTAAAGATCGAACAGATATGTTTGCTATTCACCCAACCAGTGGTGTGATAGTGTTAACTGGTAGACTTGATTACCTAGAGACCAAGCTCTATGAGATGGAAATCCTCGCTGCGGACCGTGGCATGAAGTTGTATGGGAGCAGTGGCATCAGCAGCATGGCCAAGCTAACGGTGCACATCGAACAGGCCAATGAATGTGCTCCGGTGATAACAGCAGTGACATTGTCACCATCAGAACTGGACAGGGACCCAGCATATGCAATTGTGACAGTGGATGACTGCGATCAGGGTGCCAATGGTGACATAGCATCTTTAAGCATCGTGGCAGGTGACCTTCTCCAGCAGTTTAGAACAGTGAGGTCCTTTCCAGGGAGTAAGGAGTATAAAGTCAAAGCCATCGGTGGCATTGATTGGGACAGTCATCCTTTCGGCTACAATCTCACACTACAGGCTAAAGATAAAGGAACTCCGCCCCAGTTCTCTTCTGTTAAAGTCATTCACGTGACTTCTCCACAGTTCAAAGCCGGGCCAGTCAAGTTTGAAAAGGATGTTTACAGAGCAGAAATAAGTGAATTTGCTCCTCCCAACACACCTGTGGTCATGGTAAAGGCCATTCCTGCTTATTCCCATTTGAGGTATGTTTTTAAAAGTACACCTGGAAAAGCTAAATTCAGTTTAAATTACAACACTGGTCTCATTTCTATTTTAGAACCAGTTAAAAGACAGCAGGCAGCCCATTTTGAACTTGAAGTAACAACAAGTGACAGAAAAGCGTCCACCAAGGTCTTGGTGAAAGTCTTAGGTGCAAATAGCAATCCCCCTGAATTTACCCAGACAGCGTACAAAGCTGCTTTTGATGAGAACGTGCCCATTGGTACTACTGTCATGAGCCTGAGTGCCGTAGACCCTGATGAGGGTGAGAACGGGTACGTGACATACAGTATCGCAAATTTAAATCATGTGCCGTTTGCGATTGACCATTTCACTGGTGCCGTGAGTACGTCAGAAAACCTGGACTACGAACTGATGCCTCGGGTTTATACTCTGAGGATTCGTGCATCAGACTGGGGCTTGCCGTACCGCCGGGAAGTCGAAGTCCTTGCTACAATTACTCTCAATAACTTGAATGACAACACACCTTTGTTTGAGAAAATAAATTGTGAAGGGACAATTCCCAGAGATCTAGGCGTGGGAGAGCAAATAACCACTGTTTCTGCTATTGATGCAGATGAACTTCAGTTGGTACAGTATCAGATTGAAGCTGGAAATGAACTGGATTTCTTTAGTTTAAACCCCAACTCGGGGGTATTGTCATTAAAGCGATCGCTAATGGATGGCTTAGGTGCAAAGGTGTCTTTCCACAGTCTGAGAATCACAGCTACAGATGGAGAAAATTTTGCCACACCATTATATATCAACATAACAGTGGCTGCCAGTCACAAGCTGGTAAACTTGCAGTGTGAAGAGACTGGTGTTGCCAAAATGCTGGCAGAGAAGCTCCTGCAGGCAAATAAATTACACAACCAGGGAGAGGTGGAGGATATTTTCTTCGATTCTCACTCTGTCAATGCTCACATACCGCAGTTTAGAAGCACTCTTCCGACTGGTATTCAGGTAAAGGAAAACCAGCCTGTGGGTTCCAGTGTAATTTTCATGAACTCCACTGACCTTGACACTGGCTTCAATGGAAAACTGGTCTATGCTGTTTCTGGAGGAAATGAGGATAGTTGCTTCATGATTGATATGGAAACAGGAATGCTGAAAATTTTATCTCCTCTTGACCGTGAAACAACAGACAAATACACCCTGAATATTACCGTCTATGACCTTGGGATACCCCAGAAGGCTGCGTGGCGTCTTCTACATGTCGTGGTTGTCGATGCCAATGATAATCCACCCGAGTTTTTACAGGAGAGCTATTTTGTGGAAGTGAGTGAAGACAAGGAGGTACATAGTGAAATCATCCAGGTTGAAGCCACAGATAAAGACCTGGGGCCCAACGGACACGTGACGTACTCAATTGTTACAGACACAGACACATTTTCAATTGACAGCGTGACGGGTGTTGTTAACATCGCACGCCCTCTGGATCGAGAGCTGCAGCATGAGCACTCCTTAAAGATTGAGGCCAGGGACCAAGCCAGAGAAGAGCCTCAGCTGTTCTCCACTGTCGTTGTGAAAGTATCACTAGAAGATGTTAATGACAACCCACCTACATTTATTCCACCTAATTATCGTGTGAAAGTCCGAGAGGATCTTCCAGAAGGAACCGTCATCATGTGGTTAGAAGCCCACGATCCTGATTTAGGTCAGTCTGGTCAGGTGAGATACAGCCTTCTGGACCACGGAGAAGGAAACTTCGATGTGGATAAACTCAGTGGAGCAGTTAGGATCGTCCAGCAGTTGGACTTTGAGAAGAAGCAAGTGTATAATCTCACTGTGAGGGCCAAAGACAAGGGAAAGCCAGTTTCTCTGTCTTCTACTTGCTATGTTGAAGTTGAGGTGGTTGATGTGAATGAGAACCTGCACCCACCCGTGTTTTCCAGCTTTGTGGAAAAGGGGACAGTGAAAGAAGATGCACCTGTTGGTTCATTGGTAATGACGGTGTCGGCTCATGATGAGGACGCCAGAAGAGATGGGGAGATCCGATACTCCATTAGAGATGGCTCTGGCGTTGGTGTTTTCAAAATAGGTGAAGAGACAG 24039610 Cell-type specific features of circular RNA expression. Salzman J, Chen RE, Olsen MN, Wang PL, Brown PO. PLoS Genet. 2013 HeLa RNA was treated with RNase R or a mock treatment, and then subjected to qPCR with isoform-specific primers. The fraction of linear and circular isoforms was normalized to the value measured in the mock treatment. All tested circular isoforms resisted RNase R. qRT-PCR HeLa circCSNK1G3 circRNA homo sapiens CSNK1G3 hsa_circ_0001522 hsa_circ_002171 CTCTCTATCAATATCAGCTCACATCATTGAAAAGATAATTTTGAAGACATGTTTTGCTGAAAAGACACTAAGAAAAATTTTACGAATGGGATGAACATGCTCCAGTTAATTGACTACCTACTGCAATTTGAATGTTAACATTACCCATCTGGTACAGTTACCTAGTGATGTACCTATTTTCACAATACCCTGTTTCAGTGTGCTTGTCTTGATTAAAGAATTCAAAGTGGAGTACCGCAAACTTGATATGGAAAATAAAAAGAAAGACAAGGACAAATCAGATGATAGAATGGCACGACCTAGTGGTCGATCGGGACACAACACTCGAGGAACTGGGTCTTCATCGTCTGGAGTTTTAATGGTTGGACCTAACTTTAGAGTTGGAAAAAAAATTGGATGTGGCAATTTTGGAGAATTACGATTAGGGAAAAATTTATACACAAATGAATATGTGGCAATTAAGTTGGAGCCCATGAAATCAAGAGCACCACAGCTACATTTGGAATACAGATTCTATAAGCAGTTAGGATCTGGAG 29074849 The circular RNA circBIRC6 participates in the molecular circuitry controlling human pluripotency. Yu CY, Li TC, Wu YY, Yeh CH, Chiang W, Chuang CY, Kuo HC. Nat Commun. 2017 Eenriched in hESCs (>0.1% of GAPDH levels). Downregulated in Ebs, upregulated in induced pluripotent stem cells (iPSCs) as compared with the parental fibroblasts. qRT-PCR Human embryonic stem cells, induced pluripotent stem cells hsa_circ_0001564 circRNA homo sapiens CANX hsa_circ_0001564 hsa_circ_001742 ATCATGGAAGGGAAGTGGTTGCTGTGTATGTTACTGGTGCTTGGAACTGCTATTGTTGAGGCTCATGATGGACATGATGATGATGTGATTGATATTGAGGATGACCTTGACGATGTCATTGAAGAGGTAGAAGACTCAAAACCAGATACCACTGCTCCTCCTTCATCTCCCAAGGTTACTTACAAAGCTCCAGTTCCAACAGGGGAAGTATATTTTGCTGATTCTTTTGACAGAGGAACTCTGTCAGGGTGGATTTTATCCAAAGCCAAGAAAGACGATACCGATGATGAAATTGCCAAATATGATGGAAAGTGGGAGGTAGAGGAAATGAAGGAGTCAAAGCTTCCAGGTGATAAAGGACTTGTGTTGATGTCTCGGGCCAAGCATCATGCCATCTCTGCTAAACTGAACAAGCCCTTCCTGTTTGACACCAAGCCTCTCATTGTTCAGTATGAGGTTAATTTCCAAAATGGAATAGAATGTGGTGGTGCCTATGTGAAACTGCTTTCTAAAACACCAGAACTCAACCTGGATCAGTTCCATGACAAGACCCCTTATACGATTATGTTTGGTCCAGATAAATGTGGAGAGGACTATAAACTGCACTTCATCTTCCGACACAAAAACCCCAAAACGGGTATCTATGAAGAAAAACATGCTAAGAGGCCAGATGCAGATCTGAAGACCTATTTTACTGATAAGAAAACACATCTTTACACACTAA osteosarcoma 29229385 Circular RNA hsa_circ_0001564 regulates osteosarcoma proliferation and apoptosis by acting miRNA sponge. Song YZ, Li JF. Biochem Biophys Res Commun. 2018 upregulated microarray, qRT-PCR OS tissues and adjacent non-tumor tissues, NHOst, MG63, Saos-2, HOS, and U2OS hsa_circ_0001564 knockdown suppressed osteosarcoma cells proliferation and promoted apoptosis. loss of function MG-63,HOS miR-29c-3p circRNA-miRNA HEK293 luciferase reporter assay A putative complementary region of hsa_circ_0001564 and miR-29c-3p was shown below and the complementary binding was confirmed by dual-luciferase reporter assay. hsa_circ_0001649 circRNA homo sapiens SHPRH hsa_circ_0001649 hsa_circ_001599 GGCAGCCATTCTACAAAAGTGGAAGCTGTGGTCAGAACTCTGATGAAAATACAGCTTAGAGATCCAGGGGCCAAAGCACTCGTTTTCTCAACGTGGCAAGATGTATTAGATATTATTTCAAAAGCTCTTACTGACAACAACATGGAATTTGCACAAATCAGTCGTGTTAAGACATTTCAGGAGAACCTTTCAGCATTTAAACGTGATCCCCAAATCAATATTTTGCTGCTGCCCCTGCACACAGGTTCTAATGGATTAACTATCATTGAAGCAACTCATGTTCTCTTGGTGGAGCCCATATTGAACCCTGCCCATGAGCTTCAGGCCATAGGGAGGGTGCACCGAATTGGACAGACAAAACCTACTATTGTACACAGATTCTTAATTAAAGCAACAATAGAAGAAAGAATGCAGGCAATGCTGAAAACTGCTGAGAGAAG cholangiocarcinoma (CCA) 29337065 Downregulated circular RNA hsa_circ_0001649 regulates proliferation, migration and invasion in cholangiocarcinoma cells. Xu Y, Yao Y, Zhong X, Leng K, Qin W, Qu L, Cui Y, Jiang X. Biochem Biophys Res Commun. 2018 Hsa_circ_0001649 is downregulated in both CCA tissues and cell lines. qRT-PCR HCCC-9810, RBE, CCLP1, HuCCT1, Huh-28, KMBC, QBC939 and human intrahepatic biliary epithelial cell (HIBEC), CCA tissues and the normal counterparts Downregulated hsa_circ_0001649 is linked to aggressive tumor phenotypes in CCA. Hsa_circ_0001649 regulates cell proliferation in CCA cells. Downregulated hsa_circ_0001649 attenuates CCA cell apoptosis. Hsa_circ_0001649 influences CCA cell migration and invasion capacities. Upregulated hsa_circ_0001649 suppresses tumor growth in vivo. loss of function, gain of function KMBC, Huh-28 6-week-old BALB/c nude mice CCA tissues hsa_circ_0001649 circRNA homo sapiens SHPRH hsa_circ_0001649 hsa_circ_001599 GGCAGCCATTCTACAAAAGTGGAAGCTGTGGTCAGAACTCTGATGAAAATACAGCTTAGAGATCCAGGGGCCAAAGCACTCGTTTTCTCAACGTGGCAAGATGTATTAGATATTATTTCAAAAGCTCTTACTGACAACAACATGGAATTTGCACAAATCAGTCGTGTTAAGACATTTCAGGAGAACCTTTCAGCATTTAAACGTGATCCCCAAATCAATATTTTGCTGCTGCCCCTGCACACAGGTTCTAATGGATTAACTATCATTGAAGCAACTCATGTTCTCTTGGTGGAGCCCATATTGAACCCTGCCCATGAGCTTCAGGCCATAGGGAGGGTGCACCGAATTGGACAGACAAAACCTACTATTGTACACAGATTCTTAATTAAAGCAACAATAGAAGAAAGAATGCAGGCAATGCTGAAAACTGCTGAGAGAAG hepatocellular carcinoma 26600397 Hsa_circ_0001649: A circular RNA and potential novel biomarker for hepatocellular carcinoma. Qin M, Liu G, Huo X, Tao X, Sun X, Ge Z, Yang J, Fan J, Liu L, Qin W. Cancer Biomark. 2016 significantly downregulated in HCC qRT-PCR, RT-PCR and sanger sequencing paired samples of HCC and adjacent liver tissues, HCC-LM3 and MHCC-97L The area under the ROC curve (AUC) was 0.63. Furthermore, hsa_circ_0001649 expression was correlated with tumor size (p = 0.045) and the occurrence of tumor embolus (p = 0.017) in HCC. paired samples of HCC and adjacent liver tissues hsa_circ_0001649 circRNA homo sapiens SHPRH hsa_circ_0001649 hsa_circ_001599 GGCAGCCATTCTACAAAAGTGGAAGCTGTGGTCAGAACTCTGATGAAAATACAGCTTAGAGATCCAGGGGCCAAAGCACTCGTTTTCTCAACGTGGCAAGATGTATTAGATATTATTTCAAAAGCTCTTACTGACAACAACATGGAATTTGCACAAATCAGTCGTGTTAAGACATTTCAGGAGAACCTTTCAGCATTTAAACGTGATCCCCAAATCAATATTTTGCTGCTGCCCCTGCACACAGGTTCTAATGGATTAACTATCATTGAAGCAACTCATGTTCTCTTGGTGGAGCCCATATTGAACCCTGCCCATGAGCTTCAGGCCATAGGGAGGGTGCACCGAATTGGACAGACAAAACCTACTATTGTACACAGATTCTTAATTAAAGCAACAATAGAAGAAAGAATGCAGGCAATGCTGAAAACTGCTGAGAGAAG Colorectal cancer 29421663 Hsa_circ_0001649: A circular RNA and potential novel biomarker for colorectal cancer. Ji W, Qiu C, Wang M, Mao N, Wu S, Dai Y. Biochem Biophys Res Commun. 2018 Hsa_circ_0001649 expression was down-regulated in colorectal cancer. Hsa_circ_0001649 expression was upregulated in colorectal cancer serum samples after surgery and downregulated in HCT116 cell lines. qRT-PCR tumor tissue samples and their paired paracancerous histological normal tissue, colorectal cancer serum samples after surgery , HCT116 hsa_circ_0001667 circRNA homo sapiens HEATR2 hsa_circ_0001667 hsa_circ_001717 GCCCTGCCCTGGGAGAAGCCCTGCCACACGTCGTGCCCACGCTGAGGGCCTGTCTGCAGCCCTCCCAAGACCCGCAGATGCGCCTGAAGCTGTTCTCCATCCTGTCCACCGTGCTGCTCAGAGCCACGGACACCATCAACTCCCAGGGGCAGTTTCCCAGCTACCTCGAGACGGTGACAAAGGACATCCTGGCCCCCAATCTGCAGTGGCATGCGGGGAGGACAGCCGCGGCCATCCGCACGGCTGCCGTGTCCTGCCTCTGGGCGCTCACCAGCAGCGAGGTCCTGTCGGCAGAGCAGATACGGGACGTGCAGGAAACACTGATGCCCCAGGTCCTGACCACCCTGGAGGAGGATTCGAAGATGACGCGACTGATCTCATGCCGTATTATCAACACGTTCTTAAAAACCTCGGGCGGCATGACGGATCCAGAGAAACTCATCAGGATTTATCCTG breast cancer 28803498 Screening circular RNA related to chemotherapeutic resistance in breast cancer. Gao D, Zhang X, Liu B, Meng D, Fang K, Guo Z, Li L. Epigenomics. 2017 up microarray, qRT-PCR MCF-7, ADM-resistant cell lines (MCF-7/ADM) hsa_circ_000983 circRNA homo sapiens C1GALT1 hsa_circ_0001675 hsa_circ_000983 AAATACACTTTCGGGAAATGGCCTCTAAATCCTGGCTGAATTTTTTAACCTTCCTCTGTGGATCAGCAATAGGATTTCTTTTATGTTCTCAGCTATTTAGTATTTTGTTGGGAGAAAAGGTTGACACCCAGCCTAATGTTCTTCATAATGATCCTCATGCAAGGCATTCAGATGATAATGGACAGAATCATCTAGAAGGACAAATGAACTTCAATGCAGATTCTAGCCAACATAAAGATGAGAACACAGACATTGCTGAAAACCTCTATCAGAAAGTTAGAATTCTTTGCTGGGTTATGACCGGCCCTCAAAACCTAGAGAAAAAGGCCAAACACGTCAAAGCTACTTGGGCCCAGCGTTGTAACAAAGTGTTGTTTATGAGTTCAGAAGAAAATAAAGACTTCCCTGCTGTGGGACTGAAAACCAAAGAAGGCAGAGATCAACTATACTGGAAAACAATTAAAGCTTTTCAGTATGTTCATGAACATTATTTAGAAGATGCTGATTGGTTTTTGAAAGCAGATGATGACACGTATGTCATACTAGACAATTTGAGGTGGCTTCTTTCAAAATACGACCCTGAAGAACCCATTTACTTTGGGAGAAGATTTAAGCCTTATGTAAAGCAGGGCTACATGAGTGGAGGAGCAGGATATGTACTAAGCAAAGAAGCCTTGAAAAGATTTGTTGATGCATTTAAAACAGACAAGTGTACACATAGTTCCTCCATTGAAGACTTAGCACTGGGGAGATGCATGGAAATTATGAATGTAGAAGCAGGAGATTCCAGAGATACCATTGGAAAAGAAACTTTTCATCCCTTTGTGCCAGAACACCATTTAATTAAAGGTTATCTACCTAGAACGTTTTGGTACTGGAATTACAACTATTATCCTCCTGTAGAGGGTCCTGGTTGCTGCTCTGATCTTGCAGTTTCTTTTCACTATGTTGATTCTACAACCATGTATGAGTTAGAATACCTCGTTTATCATCTTCGTCCATATGGTTATTTATACAGATATCAACCTACCTTACCTGAACGTATACTAAAGGAAATTAGTCAAGCAAACAAAAATGAAGATACAAAAGTGAAGTTAGGAAATCCTTGAAAGAAAATCATGAATGAACAAAG clear cell renal cell carcinoma 29490945 ERβ-mediated alteration of circATP2B1 and miR-204-3p signaling promotes invasion of clear cell renal cell carcinoma. Han Z, Zhang Y, Sun Y, Chen J, Chang C, Wang X, Yeh S. Cancer Res. 2018 The expression of hsa_circ_000983 is significantly decreased when ER¦Â was knocked down in 786-O cells qRT-PCR 786-O - - hsa_circ_0001721 circRNA homo sapiens CDK14 hsa_circ_0001721 hsa_circ_000457 ATATGTGTCACAAAGATGTCTACACGGAACTGCCAGGGAATGGACTCAGTGATCAAACCCCTGGACACAATTCCTGAGGATAAAAAAGTCAGAGTTCAGAGGACACAGAGCACTTTTGACCCATTTGAGAAACCAGCTAATCAAGTAAAGAGGGTGCATTCTGAGAACAATGCTTGCATTAACTTTAAGACCTCCTCCACTGGCAAAGAGTCACCTAAAGTTAGGCGGCACTCCAGCCCCAGCTCG breast cancer 28744405 Circular RNA circ-ABCB10 promotes breast cancer proliferation and progression through sponging miR-1271. Liang HF, Zhang XZ, Liu BG, Jia GT, Li WL. Am J Cancer Res. 2017 up-regulated in breast cancer microarray, qRT-PCR cancer and adjacent noncancerous tissue hsa_circ_0001727 circRNA homo sapiens ZKSCAN1 hsa_circ_0001727 hsa_circ_000017 GAATAGTAAAGAAACACATCATAAAACCTCCCAGGACATAAAGGTGAGCACAGACCCTGTTTGGATCAAGTCAGTTCCTGGAGCCTGAATGATGACTGCTGAATCACGGGAAGCCACGGGTCTGTCCCCACAGGCTGCACAGGAGAAGGATGGTATCGTAATAGTGAAGGTGGAAGAGGAAGATGAGGAAGACCACATGTGGGGGCAGGATTCCACCCTACAGGACACGCCTCCTCCAGACCCAGAGATATTCCGCCAACGCTTCAGGCGCTTCTGTTACCAGAACACTTTTGGGCCCCGAGAGGCTCTCAGTCGGCTGAAGGAACTTTGTCATCAGTGGCTGCGGCCAGAAATAAACACCAAGGAACAGATCCTGGAGCTTCTGGTGCTAGAGCAGTTTCTTTCCATCCTGCCCAAGGAGCTCCAGGTCTGGCTGCAGGAATACCGCCCCGATAGTGGAGAGGAGGCCGTGACCCTTCTAGAAGACTTGGAGCTTGATTTATCAGGACAACAGGTCCCAGGTCAAGTTCATGGACCTGAGATGCTCGCAAGGGGGATGGTGCCTCTGGATCCAGTTCAGGAGTCCTCGAGCTTTGACCTTCATCACGAGGCCACCCAGTCCCACTTCAAACATTCGTCTCGGAAACCCCGCCTCTTACAGTCACGAG 26848835 Circular RNAs Co-Precipitate with Extracellular Vesicles: A Possible Mechanism for circRNA Clearance. Lasda E, Parker R. PLoS One. 2016 detected in preparations enriched in extracellular vesicles RT-PCR, qRT-PCR extracellular vesicles from HeLa, 293T, or U-2 OS cultured cells circHIPK2 circRNA homo sapiens HIPK2 hsa_circ_0001756 hsa_circ_000012 GTATGGCCTCACATGTGCAAGTTTTCTCCCCTCACACCCTTCAATCAAGTGCCTTCTGTAGTGTGAAGAAACTGAAAATAGAGCCGAGTTCCAACTGGGACATGACTGGGTACGGCTCCCACAGCAAAGTGTATAGCCAGAGCAAGAACATCCCCCTGTCGCAGCCAGCCACCACAACCGTCAGCACCTCCTTGCCGGTCCCAAACCCAAGCCTACCTTACGAGCAGACCATCGTCTTCCCAGGAAGCACCGGGCACATCGTGGTCACCTCAGCAAGCAGCACTTCTGTCACCGGGCAAGTCCTCGGCGGACCACACAACCTAATGCGTCGAAGCACTGTGAGCCTCCTTGATACCTACCAAAAATGTGGACTCAAGCGTAAGAGCGAGGAGATCGAGAACACAAGCAGCGTGCAGATCATCGAGGAGCATCCACCCATGATTCAGAATAATGCAAGCGGGGCCACTGTCGCCACTGCCACCACGTCTACTGCCACCTCCAAAAACAGCGGCTCCAACAGCGAGGGCGACTATCAGCTGGTGCAGCATGAGGTGCTGTGCTCCATGACCAACACCTACGAGGTCTTAGAGTTCTTGGGCCGAGGGACGTTTGGGCAAGTGGTCAAGTGCTGGAAACGGGGCACCAATGAGATCGTAGCCATCAAGATCCTGAAGAACCACCCATCCTATGCCCGACAAGGTCAGATTGAAGTGAGCATCCTGGCCCGGTTGAGCACGGAGAGTGCCGATGACTATAACTTCGTCCGGGCCTACGAATGCTTCCAGCACAAGAACCACACGTGCTTGGTCTTCGAGATGTTGGAGCAGAACCTCTATGACTTTCTGAAGCAAAACAAGTTTAGCCCCTTGCCCCTCAAATACATTCGCCCAGTTCTCCAGCAGGTAGCCACAGCCCTGATGAAACTCAAAAGCCTAGGTCTTATCCACGCTGACCTCAAACCAGAAAACATCATGCTGGTGGATCCATCTAGACAACCATACAGAGTCAAGGTCATCGACTTTGGTTCAGCCAGCCACGTCTCCAAGGCTGTGTGCTCCACCTACTTGCAGTCCAGATATTACAG neuroinflammatory disorders 28786753 Circular RNA HIPK2 regulates astrocyte activation via cooperation of autophagy and ER stress by targeting MIR124-2HG. Huang R, Zhang Y, Han B, Bai Y, Zhou R, Gan G, Chao J, Hu G, Yao H. Autophagy. 2017 circHIPK2 was expressed in primary mouse astrocytes as determined by in situ hybridization analysis using a circHIPK2-specific probe. FISH primary mouse astrocytes Knockdown of circHIPK2 expression significantly inhibited astrocyte activation via the regulation of autophagy and endoplasmic reticulum (ER) stress through the targeting of MIR124¨C2HG and SIGMAR1. Microinjection of a circHIPK2 siRNA lentivirus into mouse hippocampi inhibited astrocyte activation induced by methamphetamine or lipopolysaccharide (LPS). loss of function primary mouse astrocytes the hippocampi of C57BL/6 mice MIR124¨C2HG circRNA-miRNA A172 cells, primary mouse astrocytes FISH circHIPK2 acts as an endogenous MIR124¨C2HG sponge to regulate ER stress in astrocytes. SIGMAR1 circRNA HIPK2 circRNA homo sapiens HIPK2 hsa_circ_0001756 hsa_circ_000012 GTATGGCCTCACATGTGCAAGTTTTCTCCCCTCACACCCTTCAATCAAGTGCCTTCTGTAGTGTGAAGAAACTGAAAATAGAGCCGAGTTCCAACTGGGACATGACTGGGTACGGCTCCCACAGCAAAGTGTATAGCCAGAGCAAGAACATCCCCCTGTCGCAGCCAGCCACCACAACCGTCAGCACCTCCTTGCCGGTCCCAAACCCAAGCCTACCTTACGAGCAGACCATCGTCTTCCCAGGAAGCACCGGGCACATCGTGGTCACCTCAGCAAGCAGCACTTCTGTCACCGGGCAAGTCCTCGGCGGACCACACAACCTAATGCGTCGAAGCACTGTGAGCCTCCTTGATACCTACCAAAAATGTGGACTCAAGCGTAAGAGCGAGGAGATCGAGAACACAAGCAGCGTGCAGATCATCGAGGAGCATCCACCCATGATTCAGAATAATGCAAGCGGGGCCACTGTCGCCACTGCCACCACGTCTACTGCCACCTCCAAAAACAGCGGCTCCAACAGCGAGGGCGACTATCAGCTGGTGCAGCATGAGGTGCTGTGCTCCATGACCAACACCTACGAGGTCTTAGAGTTCTTGGGCCGAGGGACGTTTGGGCAAGTGGTCAAGTGCTGGAAACGGGGCACCAATGAGATCGTAGCCATCAAGATCCTGAAGAACCACCCATCCTATGCCCGACAAGGTCAGATTGAAGTGAGCATCCTGGCCCGGTTGAGCACGGAGAGTGCCGATGACTATAACTTCGTCCGGGCCTACGAATGCTTCCAGCACAAGAACCACACGTGCTTGGTCTTCGAGATGTTGGAGCAGAACCTCTATGACTTTCTGAAGCAAAACAAGTTTAGCCCCTTGCCCCTCAAATACATTCGCCCAGTTCTCCAGCAGGTAGCCACAGCCCTGATGAAACTCAAAAGCCTAGGTCTTATCCACGCTGACCTCAAACCAGAAAACATCATGCTGGTGGATCCATCTAGACAACCATACAGAGTCAAGGTCATCGACTTTGGTTCAGCCAGCCACGTCTCCAAGGCTGTGTGCTCCACCTACTTGCAGTCCAGATATTACAG 25558066 Analysis of intron sequences reveals hallmarks of circular RNA biogenesis in animals. Ivanov A, Memczak S, Wyler E, Torti F, Porath HT, Orejuela MR, Piechotta M, Levanon EY, Landthaler M, Dieterich C, Rajewsky N. Cell Rep. 2015 This circRNA with top H score and high/medium expression of the host transcript was (1) resistant to RNase R and (2) had the predicted head-to-tail junctions, as validated by Sanger sequencing, suggesting that the circRNA exists in circularized form in HEK293 cells. qRT-PCR, sanger sequencing HEK293 cells hsa_circ_0001785 circRNA homo sapiens ELP3 hsa_circ_0001785 hsa_circ_001447 GGATATTCCAATGCCTTTAGTTAGCTCAGGAGTAGAGCATGGTAACCTGAGAGAGCTGGCACTTGCAAGAATGAAAGACCTCGGAATACAGTGTCGAGATGTGAGAACCAGAGAAGTTGGAATCCAAGAAATTCATCACAAAGTACGGCCATACCAGGTTGAATTGGTAAGGAGAGATTATGTTGCAAATGGTGGCTGGGAAACATTCTTGTCATACGAAGACCCAGATCAAGACATTTTGATTGGCCTCCTACGATTACGCAAGTGTTCAGAAGAAACTTTCCGTTTCGAATTGGGTGGAGGTGTCTCCATAGTACGAGAGCTGCATGTGTATGGGAGTGTGGTCCCTGTGAGCAGCCGGGATCCTACTAAATTTCAGCATCAGGGATTTGGCATGCTGCTGATGGAGGAAGCAGAAAGAATAGCTAGAGAAGAACATGGGTCTGGGAAAATCGCTGTGATATCAG breast cancer 29045858 Circulating circular RNA hsa_circ_0001785 acts as a diagnostic biomarker for breast cancer detection. Yin WB, Yan MG, Fang X, Guo JJ, Xiong W, Zhang RP. Clin Chim Acta. 2017 significantly increased in breast cancer patients microarray, qRT-PCR breast cancer peripheral blood specimen Hsa_circ_0001785 acted as a biomarker for breast cancer breast cancer peripheral blood specimen circPCMTD1 circRNA homo sapiens PCMTD1 hsa_circ_0001801 hsa_circ_000018 GATTAATTTATTTTTGGAAATCAAGTGCAATATTGGAAGCCATTTCTACTAATTTTATTTCACTTTTAAATTTATGATTTGATTTGAATACTATCATGGGAGGAGCTGTGAGTGCTGGGGAAGATAATGATGACTTAATTGATAATTTAAAAGAAGCTCAGTATATTCGTACTGAAAGAGTGGAGCAAGCCTTCAGAGCGATTGATCGTGGAGATTACTATTTGGAAGGCTACAGAGACAATGCTTACAAAGACTTAGCCTGGAAGCATGGAAACATCCACTTGTCAGCACCTTGCATTTATTCTGAAGTTATGGAAGCATTGAAACTTCAACCAGGATTGTCTTTTCTTAACCTGGGAAGTGGAACCGGATATTTAAGTACAATGGTGGGCTTAATTTTAG 29074849 The circular RNA circBIRC6 participates in the molecular circuitry controlling human pluripotency. Yu CY, Li TC, Wu YY, Yeh CH, Chiang W, Chuang CY, Kuo HC. Nat Commun. 2017 Eenriched in hESCs (>0.1% of GAPDH levels). Downregulated in Ebs, upregulated in induced pluripotent stem cells (iPSCs) as compared with the parental fibroblasts. qRT-PCR Human embryonic stem cells, induced pluripotent stem cells hsa_circ_0001811 circRNA homo sapiens STAU2 hsa_circ_0001811 hsa_circ_001719 ATGTTCTCAGTGCAGCTGAGTCTTGGTGAGCAGACATGGGAATCCGAAGGCAGCAGTATAAAGAAGGCTCAGCAGGCTGTTGCCAATAAAGCTTTGACTGAATCTACGCTTCCCAAACCAGTTCAGAAGCCACCCAAAAGTAATGTTAACAATAACCCAGGCAGTATAACTCCAACTGTGGAACTGAATGGGCTTGCTATGAAAAGGGGAGAGCCTGCCATCTACAGGCCATTAGATCCAAAGCCATTCCCAAATTATAGAGCTAATTACAACTTTCGGGGCATGTACAATCAGAG male infertile diseases 27958373 Identification and characterization of human testis derived circular RNAs and their existence in seminal plasma. Dong WW, Li HM, Qing XR, Huang DH, Li HG. Sci Rep. 2016 To validate these predicted circRNAs, 55 circRNAs of different abundance and lengths were randomly chosen for subsequent RT-PCR validation. Divergent primers were designed for circRNA detection. Among the 55 circRNAs, 30 of them could be specifically amplified. qRT-PCR human testis circUBR5 circRNA homo sapiens UBR5 hsa_circ_0001819 hsa_circ_000479 GTTACGAGAAGTTTCTGAGAAGCTGAACAAATATAATTTAAACAGCCACCCCCCTTTGAATGTATTGGAACAGGCTACTATTAAACAGTGTGTGGTGGGACCAAATCATGCTGCCTTTCTTCTTGAGGATGGTAGAGTTTGCAGGATTGGTTTTTCAGTACAGCCAGACAGATTGGAATTGGGTAAACCTGATAATAATGATGGGTCAAAGTTGAACAGCAACTCGGGGGCAGGGAGGACGTCAAGGCCTGGTAGGACAAGCGACTCTCCATGGTTTCTCTCAGGTTCTGAGACTCTAGGCAGGCTGGCAGGCAACACCTTAGG Lupus Nephritis 29499937 circHLA-C Plays an Important Role in Lupus Nephritis by Sponging miR-150. Luan J, Jiao C, Kong W, Fu J, Qu W, Chen Y, Zhu X, Zeng Y, Guo G, Qi H, Yao L, Pi J, Wang L, Zhou H. Mol Ther Nucleic Acids. 2018 Significantly upregulated in LN renal biopsies compared with NC kidneys RNA-seq, qRT-PCR lupus nephritis renal biopsies and negtive control kidneys CircPVT1 circRNA homo sapiens TCONS_00015354 hsa_circ_0001821 hsa_circ_000006 GCCTGATCTTTTGGCCAGAAGGAGATTAAAAAGATGCCCCTCAAGATGGCTGTGCCTGTCAGCTGCATGGAGCTTCGTTCAAGTATTTTCTGAGCCTGATGGATTTACAGTGATCTTCAGTGGTCTGGGGAATAACGCTGGTGGAACCATGCACTGGAATGACACACGCCCGGCACATTTCAGGATACTAAAAGTGGTTTTAAGGGAGGCTGTGGCTGAATGCCTCATGGATTCTTACAGCTTGGATGTCCATGGGGGACGAAGGACTGCAGCTGGCTGAGAGGGTTGAGATCTCTGTTTACTTAGATCTCTGCCAACTTCCTTTGGGTCTCCCTATGGAATGTAAGACCCCGACTCTTCCTGGTGAAGCATCTGATGCACGTTCCATCCGGCGCTCAGCTGGGCTTGAG senescence 27928058 Identification of senescence-associated circular RNAs (SAC-RNAs) reveals senescence suppressor CircPVT1. Panda AC, Grammatikakis I, Kim KM, De S, Martindale JL, Munk R, Yang X, Abdelmohsen K, Gorospe M. Nucleic Acids Res. 2017 the circRNA hsa_circ_PVT1_01 was found to be one of the most downregulated circRNAs in senescent WI-38 cells. To further validate the association of circRNA expression with cellular senescence, we induced premature senescence by exposing proliferating WI-38 cells to ionizing radiation (IR). IR-treated cells were found to have higher SA- gal activity and other markers of senescence. Most of the circRNAs showed consistent patterns of expression in replicative and IR-induced senescence, including hsa_circ_PVT1|_01, which was reduced in both instances. qRT-PCR WI-38 cells Reducing CircPVT1 levels in proliferating fibroblasts triggered senescence, as determined by a rise in senescence-associated beta-galactosidase activity, higher abundance of CDKN1A/P21 and TP53, and reduced cell proliferation. Reporter analysis revealed that CircPVT1 decreased the cellular pool of available let-7, and antagonizing endogenous let-7 triggered cell proliferation. Importantly, silencing CircPVT1 promoted cell senescence and reversed the proliferative phenotype observed after let-7 function was impaired. Consequently, the levels of several proliferative proteins that prevent senescence, such as IGF2BP1, KRAS and HMGA2, encoded by let-7 target mRNAs, were reduced by silencing CircPVT1. loss of function human WI-38 fibroblasts, MCF7 breast carcinoma cells, and IMR-90 lung fibroblasts let-7 circRNA-miRNA human WI-38 fibroblasts RNA pull-down Although several microRNAs were predicted to bind CircPVT1, only let-7 was found enriched after pulldown of endogenous CircPVT1, suggesting that CircPVT1 might selectivelymodulate let-7 activity and hence expression of let-7-regulated mRNAs. IGF2BP1, KRAS and HMGA2. hsa_circ_0001821 circRNA homo sapiens TCONS_00015354 hsa_circ_0001821 hsa_circ_000006 GCCTGATCTTTTGGCCAGAAGGAGATTAAAAAGATGCCCCTCAAGATGGCTGTGCCTGTCAGCTGCATGGAGCTTCGTTCAAGTATTTTCTGAGCCTGATGGATTTACAGTGATCTTCAGTGGTCTGGGGAATAACGCTGGTGGAACCATGCACTGGAATGACACACGCCCGGCACATTTCAGGATACTAAAAGTGGTTTTAAGGGAGGCTGTGGCTGAATGCCTCATGGATTCTTACAGCTTGGATGTCCATGGGGGACGAAGGACTGCAGCTGGCTGAGAGGGTTGAGATCTCTGTTTACTTAGATCTCTGCCAACTTCCTTTGGGTCTCCCTATGGAATGTAAGACCCCGACTCTTCCTGGTGAAGCATCTGATGCACGTTCCATCCGGCGCTCAGCTGGGCTTGAG 26848835 Circular RNAs Co-Precipitate with Extracellular Vesicles: A Possible Mechanism for circRNA Clearance. Lasda E, Parker R. PLoS One. 2016 detected in preparations enriched in extracellular vesicles RT-PCR extracellular vesicles from HeLa, 293T, or U-2 OS cultured cells circPVT1 circRNA homo sapiens TCONS_00015354 hsa_circ_0001821 hsa_circ_000006 GCCTGATCTTTTGGCCAGAAGGAGATTAAAAAGATGCCCCTCAAGATGGCTGTGCCTGTCAGCTGCATGGAGCTTCGTTCAAGTATTTTCTGAGCCTGATGGATTTACAGTGATCTTCAGTGGTCTGGGGAATAACGCTGGTGGAACCATGCACTGGAATGACACACGCCCGGCACATTTCAGGATACTAAAAGTGGTTTTAAGGGAGGCTGTGGCTGAATGCCTCATGGATTCTTACAGCTTGGATGTCCATGGGGGACGAAGGACTGCAGCTGGCTGAGAGGGTTGAGATCTCTGTTTACTTAGATCTCTGCCAACTTCCTTTGGGTCTCCCTATGGAATGTAAGACCCCGACTCTTCCTGGTGAAGCATCTGATGCACGTTCCATCCGGCGCTCAGCTGGGCTTGAG 28444238 High-purity circular RNA isolation method (RPAD) reveals vast collection of intronic circRNAs. Panda AC, De S, Grammatikakis I, Munk R, Yang X, Piao Y, Dudekula DB, Abdelmohsen K, Gorospe M. Nucleic Acids Res. 2017 circRNA junctions were indeed amplified and verifying the presence of backsplice sites in these transcripts. qRT-PCR HeLa hsa_circ_104689 circRNA homo sapiens ASAP1 hsa_circ_0001824 hsa_circ_001608 TTTCTTTCAAGATGGCTTGAAAACAGCTGATAAGTTGAAACAGTACATTGAAAAACTGGCTGCTGATTTATATAATATAAAACAGACCCAGGATGAAGAAAAGAAACAGCTAACTGCACTCCGAGACTTAATAAAATCCTCTCTTCAACTGGATCAGAAAGAAGATTCTCAGAGCCGGCAAGGAGGATACAGCATGCATCAGCTCCAGGGCAATAAGGAATATGGCAGTGAAAAGAAGGGGTACCTGCTAAAGAAAAGTGACGGGATCCGGAAAGTATGGCAGAGGAGGAAGTGTTCAGTCAAGAATGGGATTCTGACCATCTCACATGCCACA breast cancer 28484086 Identification of circular RNAs as a promising new class of diagnostic biomarkers for human breast cancer. Lü L, Sun J, Shi P, Kong W, Xu K, He B, Zhang S, Wang J. Oncotarget. 2017 elevated in breast cancer tissues microarray, qRT-PCR Breast cancer lesions and adjacent normal-appearing tissues area under the curve (AUC) is 0.61 Breast cancer lesions and adjacent normal-appearing tissues hsa_circ_104821 circRNA homo sapiens FAM120A hsa_circ_0001875 hsa_circ_001209 GTTGCACAGAGCATTGAGGATCACCATCAGGAAGTGATTGGTTTCTGCAGAGAGAATGGTTTCCATGGCTTGGTTGCGTATGACTCTGATTATGCACTGTGCAACATCCCCTACTATTTCAGTGCCCATGCCCTAAAACTGAGCCGGAACGGGAAAAGTCTCACCACAAGCCAATATCTGATGCATGAAGTTGCCAAGCAACTGGACCTGAATCCAAATCGTTTTCCTATTTTTGCTGCTCTCTTAGGAAATCACATTCTGCCTGATGAAGATCTGGCTTCCTTTCACTGGAGTTTACTTGGTCCAGAACATCCACTAGCCTCACTAAAGGTCCGGGCCCACCAGCTGGTCTTGCCACCTTGCGACGTAGTGATCAAAGCCGTTGCTGACTATGTACGCAACATTCAGGACACCTCTGACTTGGATGCCATAGCTAAAGATGTTTTCCAGCATTCACAGTCTAGAACAGATGACAAAGTTATTCGATTTAAGAGAGCAATTGGATATTATTCAGCGACTAGTAAGCCTATGTCATTTCATCCACCACATTACTTAG breast cancer 28484086 Identification of circular RNAs as a promising new class of diagnostic biomarkers for human breast cancer. Lü L, Sun J, Shi P, Kong W, Xu K, He B, Zhang S, Wang J. Oncotarget. 2017 elevated in breast cancer tissues microarray, qRT-PCR Breast cancer lesions and adjacent normal-appearing tissues area under the curve (AUC) is 0.60 Breast cancer lesions and adjacent normal-appearing tissues hsa_circ_0001895 circRNA homo sapiens PRRC2B hsa_circ_0001895 hsa_circ_000760 GCAGATCGGGAGCGGTGCCGAGAAAAATTTCCTTACTAGATGACATTTCATCGCAATGTCCGATCGTTTGGGGCAAATTACCAAGGGCAAGGATGGGAAAAGCAAGTACTCGACTCTCAGCCTGTTTGATAAGTATAAAGGAAAATCAGTAGACGCGATTAGATCCTCAGTTATTCCTAGACATGGCTTACAGAGTCTTGGGAAAGTTGCTGCAGCCCGGCGCATGCCACCGCCTGCAAACCTGCCAAGCTTGAAGTCTGAAAACAAAGGAAACGACCCCAACATCGTGATAGTACCCAAGGACGGGACGGGATGGGCAAACAAGCAGGATCAGCAAGACCCAAAGAG gastric cancer 28443463 Decreased expression of hsa_circ_0001895 in human gastric cancer and its clinical significances. Shao Y, Chen L, Lu R, Zhang X, Xiao B, Ye G, Guo J. Tumour Biol. 2017 hsa_circ_0001895 expression level was significantly decreased in gastric cancer qRT-PCR gastric cancer tissues and their adjacent non-tumorous tissues, GES-1, AGS, BGC-823, HGC-27, MGC-803, and SGC-7901 The area under the ROC curve (AUC) was up to 0.792 (95% confidence interval (CI) = 0.717¨C0.867; p < 0.001). gastric cancer tissues circCAMSAP1 circRNA homo sapiens CAMSAP1 hsa_circ_0001900 hsa_circ_000004 ATAACATCCCTGAGGACCTCAGAGACCCTTTCTACGTTGACCAGTATGAGCAGGAGCACATTAAGCCGCCTGTTATCAAGCTTCTCCTGTCCAGCGAGCTGTACTGCCGTGTCTGCAGCCTCATCCTGAAAGGGGACCAGGTGGCCGCCTTACAGGGACACCAGTCTGTCATCCAGGCCCTGTCCCGGAAAGGGATCTATGTGATGGAGAGTGATGACACCCCCGTGACAGAGTCCGACCTCAGTCGCGCACCCATAAAAATGAGTGCCCACATGGCAATGGTGGATGCCCTGATGATGGCCTACACTGTGGAGATGATCAGCATCGAGAAGGTGGTGGCCAGTGTCAAGCGCTTCTCAACGTTCAGTGCCTCGAAAGAACTTCCGTACGACCTCGAGGATGCCATGGTGTTCTGGATCAACAAG 29074849 The circular RNA circBIRC6 participates in the molecular circuitry controlling human pluripotency. Yu CY, Li TC, Wu YY, Yeh CH, Chiang W, Chuang CY, Kuo HC. Nat Commun. 2017 Eenriched in hESCs (>0.1% of GAPDH levels). Downregulated in Ebs, upregulated in induced pluripotent stem cells (iPSCs) as compared with the parental fibroblasts. qRT-PCR Human embryonic stem cells, induced pluripotent stem cells ciRS-7 circRNA homo sapiens CDR1 hsa_circ_0001946 CDR1as GGTTTCCGATGGCACCTGTGTCAAGGTCTTCCAACAACTCCGGGTCTTCCAGCGACTTCAAGTCTTCCAATAATCTCAAGGTCTTCCAGATAATCCTGAGCTTCCAGAAAATCCACATCTTCCAGACAATCCATGTCTTCCGGACAATCCATGTCTTCCAAGAAGCTCCAAGTCTTCCAGTAAATCAAGTCTTCCAGCAAATCCAGTCTTCCAGCAATTACTGGTCTTCCACCAAATCCAGATCTTCCAGGAAAATCCACGTCTTCCAGGAAATCCATGTCTTCCAATAATTTCAAGGTCTTCCATCAAATACAGATCTTCCAGCTAATCCATGTCTTCCAGAAAAATCTGTGTCTTCCACCAAATCCAAGTCTTCCAGTAAATCTAGTTCTTCCAGAAAAATCTAGATCTTCCAGTCAATCAGTGTCTTCCAGAAAGAAATCCAGGTCTTCCAGTCAATCAGTGTCTTCCAGAAAGAAATCCAGGTCTTCCAGTCAGTCAGTGTCTTCCAGAAAAATCTACGTCTTCCACCAAATCCAGGTCTTCCAGTCAATCCACATCTTCCGGAAAAAATCCAGGTCTTCCAGCCAATATATGTCTTCCTGAAGATCCACGTCTTCCAGAAAATCCATGTCTTCCAGAAAATCCATGTCTTCCAGTAACCTCCCAGTCTTCCAGAAAATCCACGTCTTCCCAACAATCCAAGTCTTCCGGATAATTTGGGTCTTCCTGAAAATCTACGTCTTCCAAAAAAGCCATGTCTTCCAGAAAATCCACATCTTCCAATGGCCTCCAGGTCTTCCAGACTATCCATGTCTTCCAGAAAATCCTTGTCTTCCCTTAAATCTATAGCTTCCAAAAAATCCGGGTCTTCCAGGAAATCCGTGTCTTCCAGCAAGTCCACGTCTTCCAACAAAGCCATGTCTTCCAGACTATCCATGTCTTCCAGAAAATCCTTGTCTTCCCTCAAATCCATAGCTTCCGAAAAATCCAGGTCTTCCAGGAAATCCGTGTCTTCCAGCAAATCCACGTCTTCCAACAAAGCCATGTCTTCCATCAAATTAATGTCTTCCAGCCTACTTGTGTCTTCCAACAAAGGTACGTCTTCCAACAAAGGTACGTCTTCCAACAAAGGTATGTCTTCCAACAAAGGTACGTCTTCCAGAAAATCCACGTCTTCCAACCAAGCCATGTCTTCCAGAAAATCCACGTCTTCCAGAAAATATATGTCTTCCAACTAAGCTACGTCTTCCAACAAATCCATGTCTTCCTATATCTCCAGGTCTTCCAGCATCTCCAGGGCTTCCAGCATCTGCTCGTCTTCCAACATCTCCACGTCTTCCAGCATCTCTGTGTCTTCCAGCATCTTCATGTCTTCCAACAACTACCCAGTCTTCCATCAACTGGCTCAATATCCATGTCTTCCAACGTCTCCAGTGTGCTGATCTTCTGACATTCAGGTCTTCCAGTGTCTGCAATATCCAG Colorectal Cancer 28174233 Circular RNA ciRS-7-A Promising Prognostic Biomarker and a Potential Therapeutic Target in Colorectal Cancer. Weng W, Wei Q, Toden S, Yoshida K, Nagasaka T, Fujiwara T, Cai S, Qin H, Ma Y, Goel A. Clin Cancer Res. 2017 overexpressed in colorectal cancer qRT-PCR pairs of cancer and normal mucosa specimens from colorectal cancer patients, HCT-116 and HT-29 High ciRS-7 expression correlates with advanced tumor stage, tumor depth, and metastasis in colorectal cancer patients. Overexpression of ciRS-7 in HCT116 and HT29 cells led to the blocking of miR-7 and resulted in a more aggressive oncogenic phenotype, and ciRS-7 overexpression permitted the inhibition of miR-7 and subsequent activation of EGFR and RAF1 oncogenes. CiRS-7 activated EGFR/RAF1/MAPKpathway via suppression of miR-7 activity. High ciRS-7 expression correlated with significantly poor overall survival. gain of function HCT-116 and HT-29 5 week old male athymic nude mice colorectal cancer tissues miR-7 circRNA-miRNA HCT-116 and HT-29 expression ciRS-7 overexpression dramatically reduced miR-7 tumor-suppressive function EGFR and RAF1 ciRS-7 circRNA homo sapiens CDR1 hsa_circ_0001946 CDR1as GGTTTCCGATGGCACCTGTGTCAAGGTCTTCCAACAACTCCGGGTCTTCCAGCGACTTCAAGTCTTCCAATAATCTCAAGGTCTTCCAGATAATCCTGAGCTTCCAGAAAATCCACATCTTCCAGACAATCCATGTCTTCCGGACAATCCATGTCTTCCAAGAAGCTCCAAGTCTTCCAGTAAATCAAGTCTTCCAGCAAATCCAGTCTTCCAGCAATTACTGGTCTTCCACCAAATCCAGATCTTCCAGGAAAATCCACGTCTTCCAGGAAATCCATGTCTTCCAATAATTTCAAGGTCTTCCATCAAATACAGATCTTCCAGCTAATCCATGTCTTCCAGAAAAATCTGTGTCTTCCACCAAATCCAAGTCTTCCAGTAAATCTAGTTCTTCCAGAAAAATCTAGATCTTCCAGTCAATCAGTGTCTTCCAGAAAGAAATCCAGGTCTTCCAGTCAATCAGTGTCTTCCAGAAAGAAATCCAGGTCTTCCAGTCAGTCAGTGTCTTCCAGAAAAATCTACGTCTTCCACCAAATCCAGGTCTTCCAGTCAATCCACATCTTCCGGAAAAAATCCAGGTCTTCCAGCCAATATATGTCTTCCTGAAGATCCACGTCTTCCAGAAAATCCATGTCTTCCAGAAAATCCATGTCTTCCAGTAACCTCCCAGTCTTCCAGAAAATCCACGTCTTCCCAACAATCCAAGTCTTCCGGATAATTTGGGTCTTCCTGAAAATCTACGTCTTCCAAAAAAGCCATGTCTTCCAGAAAATCCACATCTTCCAATGGCCTCCAGGTCTTCCAGACTATCCATGTCTTCCAGAAAATCCTTGTCTTCCCTTAAATCTATAGCTTCCAAAAAATCCGGGTCTTCCAGGAAATCCGTGTCTTCCAGCAAGTCCACGTCTTCCAACAAAGCCATGTCTTCCAGACTATCCATGTCTTCCAGAAAATCCTTGTCTTCCCTCAAATCCATAGCTTCCGAAAAATCCAGGTCTTCCAGGAAATCCGTGTCTTCCAGCAAATCCACGTCTTCCAACAAAGCCATGTCTTCCATCAAATTAATGTCTTCCAGCCTACTTGTGTCTTCCAACAAAGGTACGTCTTCCAACAAAGGTACGTCTTCCAACAAAGGTATGTCTTCCAACAAAGGTACGTCTTCCAGAAAATCCACGTCTTCCAACCAAGCCATGTCTTCCAGAAAATCCACGTCTTCCAGAAAATATATGTCTTCCAACTAAGCTACGTCTTCCAACAAATCCATGTCTTCCTATATCTCCAGGTCTTCCAGCATCTCCAGGGCTTCCAGCATCTGCTCGTCTTCCAACATCTCCACGTCTTCCAGCATCTCTGTGTCTTCCAGCATCTTCATGTCTTCCAACAACTACCCAGTCTTCCATCAACTGGCTCAATATCCATGTCTTCCAACGTCTCCAGTGTGCTGATCTTCTGACATTCAGGTCTTCCAGTGTCTGCAATATCCAG 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency. Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, Loewer A, Ziebold U, Landthaler M, Kocks C, le Noble F, Rajewsky N. Nature. 2013 CDR1as and miR-7 were both highly expressed in brain tissues, but CDR1as was expressed at low levels or absent in non-neuronal tissues, including tissues with very high miR-7 expression. qRT-PCR HEK293, mouse tissues, MIN6 cells Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. gain of function HEK293 zebrafish embryos miR-7 circRNA-miRNA HEK293, mouse tissues, MIN6 cells FISH, qRT-PCR We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. ciRS-7 circRNA homo sapiens CDR1 hsa_circ_0001946 CDR1as GGTTTCCGATGGCACCTGTGTCAAGGTCTTCCAACAACTCCGGGTCTTCCAGCGACTTCAAGTCTTCCAATAATCTCAAGGTCTTCCAGATAATCCTGAGCTTCCAGAAAATCCACATCTTCCAGACAATCCATGTCTTCCGGACAATCCATGTCTTCCAAGAAGCTCCAAGTCTTCCAGTAAATCAAGTCTTCCAGCAAATCCAGTCTTCCAGCAATTACTGGTCTTCCACCAAATCCAGATCTTCCAGGAAAATCCACGTCTTCCAGGAAATCCATGTCTTCCAATAATTTCAAGGTCTTCCATCAAATACAGATCTTCCAGCTAATCCATGTCTTCCAGAAAAATCTGTGTCTTCCACCAAATCCAAGTCTTCCAGTAAATCTAGTTCTTCCAGAAAAATCTAGATCTTCCAGTCAATCAGTGTCTTCCAGAAAGAAATCCAGGTCTTCCAGTCAATCAGTGTCTTCCAGAAAGAAATCCAGGTCTTCCAGTCAGTCAGTGTCTTCCAGAAAAATCTACGTCTTCCACCAAATCCAGGTCTTCCAGTCAATCCACATCTTCCGGAAAAAATCCAGGTCTTCCAGCCAATATATGTCTTCCTGAAGATCCACGTCTTCCAGAAAATCCATGTCTTCCAGAAAATCCATGTCTTCCAGTAACCTCCCAGTCTTCCAGAAAATCCACGTCTTCCCAACAATCCAAGTCTTCCGGATAATTTGGGTCTTCCTGAAAATCTACGTCTTCCAAAAAAGCCATGTCTTCCAGAAAATCCACATCTTCCAATGGCCTCCAGGTCTTCCAGACTATCCATGTCTTCCAGAAAATCCTTGTCTTCCCTTAAATCTATAGCTTCCAAAAAATCCGGGTCTTCCAGGAAATCCGTGTCTTCCAGCAAGTCCACGTCTTCCAACAAAGCCATGTCTTCCAGACTATCCATGTCTTCCAGAAAATCCTTGTCTTCCCTCAAATCCATAGCTTCCGAAAAATCCAGGTCTTCCAGGAAATCCGTGTCTTCCAGCAAATCCACGTCTTCCAACAAAGCCATGTCTTCCATCAAATTAATGTCTTCCAGCCTACTTGTGTCTTCCAACAAAGGTACGTCTTCCAACAAAGGTACGTCTTCCAACAAAGGTATGTCTTCCAACAAAGGTACGTCTTCCAGAAAATCCACGTCTTCCAACCAAGCCATGTCTTCCAGAAAATCCACGTCTTCCAGAAAATATATGTCTTCCAACTAAGCTACGTCTTCCAACAAATCCATGTCTTCCTATATCTCCAGGTCTTCCAGCATCTCCAGGGCTTCCAGCATCTGCTCGTCTTCCAACATCTCCACGTCTTCCAGCATCTCTGTGTCTTCCAGCATCTTCATGTCTTCCAACAACTACCCAGTCTTCCATCAACTGGCTCAATATCCATGTCTTCCAACGTCTCCAGTGTGCTGATCTTCTGACATTCAGGTCTTCCAGTGTCTGCAATATCCAG 21964070 miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA. Hansen TB, Wiklund ED, Bramsen JB, Villadsen SB, Statham AL, Clark SJ, Kjems J. EMBO J. 2011 The antisense (ciRS-7) levels were several orders of magnitude higher than CDR1 mRNA levels, indicating that the non-coding antisense transcript is the predominant RNA species of the CDR1 locus. The circular CDR1 NAT (ciRS-7) is highly expressed in brain. qRT-PCR, northern blots HEK293, human brain tissue Downregulation of circular antisense (ciRS-7) has a concomitant decrease in CDR1 mRNA levels, independently of heterochromatin formation. HEK293 miR-671 circRNA-miRNA HEK293 luciferase reporters, northern blot, qRT-PCR Sequence specific miR-671-mediated cleavage regulates homeostasis of the circular CDR1 antisense (ciRS-7). CDR1 miR-671 directs cleavage of a circular antisense transcript of the Cerebellar Degeneration-Related protein 1 (CDR1) locus in an Ago2-slicer-dependent manner. ciRS-7 circRNA homo sapiens CDR1 hsa_circ_0001946 CDR1as GGTTTCCGATGGCACCTGTGTCAAGGTCTTCCAACAACTCCGGGTCTTCCAGCGACTTCAAGTCTTCCAATAATCTCAAGGTCTTCCAGATAATCCTGAGCTTCCAGAAAATCCACATCTTCCAGACAATCCATGTCTTCCGGACAATCCATGTCTTCCAAGAAGCTCCAAGTCTTCCAGTAAATCAAGTCTTCCAGCAAATCCAGTCTTCCAGCAATTACTGGTCTTCCACCAAATCCAGATCTTCCAGGAAAATCCACGTCTTCCAGGAAATCCATGTCTTCCAATAATTTCAAGGTCTTCCATCAAATACAGATCTTCCAGCTAATCCATGTCTTCCAGAAAAATCTGTGTCTTCCACCAAATCCAAGTCTTCCAGTAAATCTAGTTCTTCCAGAAAAATCTAGATCTTCCAGTCAATCAGTGTCTTCCAGAAAGAAATCCAGGTCTTCCAGTCAATCAGTGTCTTCCAGAAAGAAATCCAGGTCTTCCAGTCAGTCAGTGTCTTCCAGAAAAATCTACGTCTTCCACCAAATCCAGGTCTTCCAGTCAATCCACATCTTCCGGAAAAAATCCAGGTCTTCCAGCCAATATATGTCTTCCTGAAGATCCACGTCTTCCAGAAAATCCATGTCTTCCAGAAAATCCATGTCTTCCAGTAACCTCCCAGTCTTCCAGAAAATCCACGTCTTCCCAACAATCCAAGTCTTCCGGATAATTTGGGTCTTCCTGAAAATCTACGTCTTCCAAAAAAGCCATGTCTTCCAGAAAATCCACATCTTCCAATGGCCTCCAGGTCTTCCAGACTATCCATGTCTTCCAGAAAATCCTTGTCTTCCCTTAAATCTATAGCTTCCAAAAAATCCGGGTCTTCCAGGAAATCCGTGTCTTCCAGCAAGTCCACGTCTTCCAACAAAGCCATGTCTTCCAGACTATCCATGTCTTCCAGAAAATCCTTGTCTTCCCTCAAATCCATAGCTTCCGAAAAATCCAGGTCTTCCAGGAAATCCGTGTCTTCCAGCAAATCCACGTCTTCCAACAAAGCCATGTCTTCCATCAAATTAATGTCTTCCAGCCTACTTGTGTCTTCCAACAAAGGTACGTCTTCCAACAAAGGTACGTCTTCCAACAAAGGTATGTCTTCCAACAAAGGTACGTCTTCCAGAAAATCCACGTCTTCCAACCAAGCCATGTCTTCCAGAAAATCCACGTCTTCCAGAAAATATATGTCTTCCAACTAAGCTACGTCTTCCAACAAATCCATGTCTTCCTATATCTCCAGGTCTTCCAGCATCTCCAGGGCTTCCAGCATCTGCTCGTCTTCCAACATCTCCACGTCTTCCAGCATCTCTGTGTCTTCCAGCATCTTCATGTCTTCCAACAACTACCCAGTCTTCCATCAACTGGCTCAATATCCATGTCTTCCAACGTCTCCAGTGTGCTGATCTTCTGACATTCAGGTCTTCCAGTGTCTGCAATATCCAG 23446346 Natural RNA circles function as efficient microRNA sponges. Hansen TB, Jensen TI, Clausen BH, Bramsen JB, Finsen B, Damgaard CK, Kjems J. Nature. 2013 As in HEK293 cells, the stably expressed ciRS-7 in HeLa cells was sensitive towards miR-671 as shown previously, but remained resistant to miR-7. qRT-PCR, northern blots HEK293, HeLa, mouse brain tissue Although the circRNA (ciRS-7) is completely resistant to miRNA-mediated target destabilization, it strongly suppresses miR-7 activity, resulting in increased levels of miR-7 targets. HEK293, HeLa C57BL/6 male mice miR-7 circRNA-miRNA HEK293, HeLa northern blots, qRT-PCR ciRS-7 contains more than 70 selectively conserved miRNA target sites, and it is highly and widely associated with Argonaute (AGO) proteins in a miR-7-dependent manner. SNCA, EGFR, IRS2 hsa_circ_0001946 circRNA homo sapiens CDR1 hsa_circ_0001946 CDR1-as GGTTTCCGATGGCACCTGTGTCAAGGTCTTCCAACAACTCCGGGTCTTCCAGCGACTTCAAGTCTTCCAATAATCTCAAGGTCTTCCAGATAATCCTGAGCTTCCAGAAAATCCACATCTTCCAGACAATCCATGTCTTCCGGACAATCCATGTCTTCCAAGAAGCTCCAAGTCTTCCAGTAAATCAAGTCTTCCAGCAAATCCAGTCTTCCAGCAATTACTGGTCTTCCACCAAATCCAGATCTTCCAGGAAAATCCACGTCTTCCAGGAAATCCATGTCTTCCAATAATTTCAAGGTCTTCCATCAAATACAGATCTTCCAGCTAATCCATGTCTTCCAGAAAAATCTGTGTCTTCCACCAAATCCAAGTCTTCCAGTAAATCTAGTTCTTCCAGAAAAATCTAGATCTTCCAGTCAATCAGTGTCTTCCAGAAAGAAATCCAGGTCTTCCAGTCAATCAGTGTCTTCCAGAAAGAAATCCAGGTCTTCCAGTCAGTCAGTGTCTTCCAGAAAAATCTACGTCTTCCACCAAATCCAGGTCTTCCAGTCAATCCACATCTTCCGGAAAAAATCCAGGTCTTCCAGCCAATATATGTCTTCCTGAAGATCCACGTCTTCCAGAAAATCCATGTCTTCCAGAAAATCCATGTCTTCCAGTAACCTCCCAGTCTTCCAGAAAATCCACGTCTTCCCAACAATCCAAGTCTTCCGGATAATTTGGGTCTTCCTGAAAATCTACGTCTTCCAAAAAAGCCATGTCTTCCAGAAAATCCACATCTTCCAATGGCCTCCAGGTCTTCCAGACTATCCATGTCTTCCAGAAAATCCTTGTCTTCCCTTAAATCTATAGCTTCCAAAAAATCCGGGTCTTCCAGGAAATCCGTGTCTTCCAGCAAGTCCACGTCTTCCAACAAAGCCATGTCTTCCAGACTATCCATGTCTTCCAGAAAATCCTTGTCTTCCCTCAAATCCATAGCTTCCGAAAAATCCAGGTCTTCCAGGAAATCCGTGTCTTCCAGCAAATCCACGTCTTCCAACAAAGCCATGTCTTCCATCAAATTAATGTCTTCCAGCCTACTTGTGTCTTCCAACAAAGGTACGTCTTCCAACAAAGGTACGTCTTCCAACAAAGGTATGTCTTCCAACAAAGGTACGTCTTCCAGAAAATCCACGTCTTCCAACCAAGCCATGTCTTCCAGAAAATCCACGTCTTCCAGAAAATATATGTCTTCCAACTAAGCTACGTCTTCCAACAAATCCATGTCTTCCTATATCTCCAGGTCTTCCAGCATCTCCAGGGCTTCCAGCATCTGCTCGTCTTCCAACATCTCCACGTCTTCCAGCATCTCTGTGTCTTCCAGCATCTTCATGTCTTCCAACAACTACCCAGTCTTCCATCAACTGGCTCAATATCCATGTCTTCCAACGTCTCCAGTGTGCTGATCTTCTGACATTCAGGTCTTCCAGTGTCTGCAATATCCAG 26848835 Circular RNAs Co-Precipitate with Extracellular Vesicles: A Possible Mechanism for circRNA Clearance. Lasda E, Parker R. PLoS One. 2016 detected in preparations enriched in extracellular vesicles RT-PCR extracellular vesicles from HeLa, 293T, or U-2 OS cultured cells ciRS-7 circRNA homo sapiens CDR1 hsa_circ_0001946 CDR1as GGTTTCCGATGGCACCTGTGTCAAGGTCTTCCAACAACTCCGGGTCTTCCAGCGACTTCAAGTCTTCCAATAATCTCAAGGTCTTCCAGATAATCCTGAGCTTCCAGAAAATCCACATCTTCCAGACAATCCATGTCTTCCGGACAATCCATGTCTTCCAAGAAGCTCCAAGTCTTCCAGTAAATCAAGTCTTCCAGCAAATCCAGTCTTCCAGCAATTACTGGTCTTCCACCAAATCCAGATCTTCCAGGAAAATCCACGTCTTCCAGGAAATCCATGTCTTCCAATAATTTCAAGGTCTTCCATCAAATACAGATCTTCCAGCTAATCCATGTCTTCCAGAAAAATCTGTGTCTTCCACCAAATCCAAGTCTTCCAGTAAATCTAGTTCTTCCAGAAAAATCTAGATCTTCCAGTCAATCAGTGTCTTCCAGAAAGAAATCCAGGTCTTCCAGTCAATCAGTGTCTTCCAGAAAGAAATCCAGGTCTTCCAGTCAGTCAGTGTCTTCCAGAAAAATCTACGTCTTCCACCAAATCCAGGTCTTCCAGTCAATCCACATCTTCCGGAAAAAATCCAGGTCTTCCAGCCAATATATGTCTTCCTGAAGATCCACGTCTTCCAGAAAATCCATGTCTTCCAGAAAATCCATGTCTTCCAGTAACCTCCCAGTCTTCCAGAAAATCCACGTCTTCCCAACAATCCAAGTCTTCCGGATAATTTGGGTCTTCCTGAAAATCTACGTCTTCCAAAAAAGCCATGTCTTCCAGAAAATCCACATCTTCCAATGGCCTCCAGGTCTTCCAGACTATCCATGTCTTCCAGAAAATCCTTGTCTTCCCTTAAATCTATAGCTTCCAAAAAATCCGGGTCTTCCAGGAAATCCGTGTCTTCCAGCAAGTCCACGTCTTCCAACAAAGCCATGTCTTCCAGACTATCCATGTCTTCCAGAAAATCCTTGTCTTCCCTCAAATCCATAGCTTCCGAAAAATCCAGGTCTTCCAGGAAATCCGTGTCTTCCAGCAAATCCACGTCTTCCAACAAAGCCATGTCTTCCATCAAATTAATGTCTTCCAGCCTACTTGTGTCTTCCAACAAAGGTACGTCTTCCAACAAAGGTACGTCTTCCAACAAAGGTATGTCTTCCAACAAAGGTACGTCTTCCAGAAAATCCACGTCTTCCAACCAAGCCATGTCTTCCAGAAAATCCACGTCTTCCAGAAAATATATGTCTTCCAACTAAGCTACGTCTTCCAACAAATCCATGTCTTCCTATATCTCCAGGTCTTCCAGCATCTCCAGGGCTTCCAGCATCTGCTCGTCTTCCAACATCTCCACGTCTTCCAGCATCTCTGTGTCTTCCAGCATCTTCATGTCTTCCAACAACTACCCAGTCTTCCATCAACTGGCTCAATATCCATGTCTTCCAACGTCTCCAGTGTGCTGATCTTCTGACATTCAGGTCTTCCAGTGTCTGCAATATCCAG hepatocellular carcinoma 27614453 The circular RNA ciRS-7 (Cdr1as) acts as a risk factor of hepatic microvascular invasion in hepatocellular carcinoma. Xu L, Zhang M, Zheng X, Yi P, Lan C, Xu M. J Cancer Res Clin Oncol. 2017 There was no significant difference of ciRS-7 expression levels between the HCC tissues and the matched non-tumor tissues (0.67+/-1.49 vs. 0.44+/-0.45, p = 0.13), and the ciRS-7 levels in more than half of HCC tissues (65 out of 108, 60.2 %) were down-regulated when compared with their matched non-tumor tissues. qRT-PCR, sanger sequencing HCC and the non-tumor tissues The highly ciRS-7 expression in HCC tissues was significantly correlated with hepatic MVI, AFP level and younger age and thus partly related with the deterioration of HCC. Especially, ciRS-7 was one of the independent factors of hepatic MVI. These data suggested that ciRS-7 may be a promising biomarker of hepatic MVI and a novel therapy target for restraining MVI. CiRS 7 is an independent risk factor of microvascular invasion. HCC and the non-tumor tissues miR-7 circRNA-miRNA PIK3CD, p70S6K, mTOR ciRS-7 circRNA homo sapiens CDR1 hsa_circ_0001946 CDR1as GGTTTCCGATGGCACCTGTGTCAAGGTCTTCCAACAACTCCGGGTCTTCCAGCGACTTCAAGTCTTCCAATAATCTCAAGGTCTTCCAGATAATCCTGAGCTTCCAGAAAATCCACATCTTCCAGACAATCCATGTCTTCCGGACAATCCATGTCTTCCAAGAAGCTCCAAGTCTTCCAGTAAATCAAGTCTTCCAGCAAATCCAGTCTTCCAGCAATTACTGGTCTTCCACCAAATCCAGATCTTCCAGGAAAATCCACGTCTTCCAGGAAATCCATGTCTTCCAATAATTTCAAGGTCTTCCATCAAATACAGATCTTCCAGCTAATCCATGTCTTCCAGAAAAATCTGTGTCTTCCACCAAATCCAAGTCTTCCAGTAAATCTAGTTCTTCCAGAAAAATCTAGATCTTCCAGTCAATCAGTGTCTTCCAGAAAGAAATCCAGGTCTTCCAGTCAATCAGTGTCTTCCAGAAAGAAATCCAGGTCTTCCAGTCAGTCAGTGTCTTCCAGAAAAATCTACGTCTTCCACCAAATCCAGGTCTTCCAGTCAATCCACATCTTCCGGAAAAAATCCAGGTCTTCCAGCCAATATATGTCTTCCTGAAGATCCACGTCTTCCAGAAAATCCATGTCTTCCAGAAAATCCATGTCTTCCAGTAACCTCCCAGTCTTCCAGAAAATCCACGTCTTCCCAACAATCCAAGTCTTCCGGATAATTTGGGTCTTCCTGAAAATCTACGTCTTCCAAAAAAGCCATGTCTTCCAGAAAATCCACATCTTCCAATGGCCTCCAGGTCTTCCAGACTATCCATGTCTTCCAGAAAATCCTTGTCTTCCCTTAAATCTATAGCTTCCAAAAAATCCGGGTCTTCCAGGAAATCCGTGTCTTCCAGCAAGTCCACGTCTTCCAACAAAGCCATGTCTTCCAGACTATCCATGTCTTCCAGAAAATCCTTGTCTTCCCTCAAATCCATAGCTTCCGAAAAATCCAGGTCTTCCAGGAAATCCGTGTCTTCCAGCAAATCCACGTCTTCCAACAAAGCCATGTCTTCCATCAAATTAATGTCTTCCAGCCTACTTGTGTCTTCCAACAAAGGTACGTCTTCCAACAAAGGTACGTCTTCCAACAAAGGTATGTCTTCCAACAAAGGTACGTCTTCCAGAAAATCCACGTCTTCCAACCAAGCCATGTCTTCCAGAAAATCCACGTCTTCCAGAAAATATATGTCTTCCAACTAAGCTACGTCTTCCAACAAATCCATGTCTTCCTATATCTCCAGGTCTTCCAGCATCTCCAGGGCTTCCAGCATCTGCTCGTCTTCCAACATCTCCACGTCTTCCAGCATCTCTGTGTCTTCCAGCATCTTCATGTCTTCCAACAACTACCCAGTCTTCCATCAACTGGCTCAATATCCATGTCTTCCAACGTCTCCAGTGTGCTGATCTTCTGACATTCAGGTCTTCCAGTGTCTGCAATATCCAG 29236709 ciRS-7 exonic sequence is embedded in a long non-coding RNA locus. Barrett SP, Parker KR, Horn C, Mata M, Salzman J. PLoS Genet. 2017 The promoters of a nearby uncharacterized locus currently annotated as a long non-coding RNA (LINC00632) were responsible for driving ciRS-7 expression. RT-PCR HEK293T ciRS-7 is like other circRNAs, as it is spliced into linear transcripts. Expression of ciRS-7 is primarily determined by the chromatin state of LINC00632 promoters. Transcription and splicing factors sufficient for ciRS-7 biogenesis are expressed in cells that lack detectable ciRS-7 expression. ciRS-7 circRNA homo sapiens CDR1 hsa_circ_0001946 CDR1as GGTTTCCGATGGCACCTGTGTCAAGGTCTTCCAACAACTCCGGGTCTTCCAGCGACTTCAAGTCTTCCAATAATCTCAAGGTCTTCCAGATAATCCTGAGCTTCCAGAAAATCCACATCTTCCAGACAATCCATGTCTTCCGGACAATCCATGTCTTCCAAGAAGCTCCAAGTCTTCCAGTAAATCAAGTCTTCCAGCAAATCCAGTCTTCCAGCAATTACTGGTCTTCCACCAAATCCAGATCTTCCAGGAAAATCCACGTCTTCCAGGAAATCCATGTCTTCCAATAATTTCAAGGTCTTCCATCAAATACAGATCTTCCAGCTAATCCATGTCTTCCAGAAAAATCTGTGTCTTCCACCAAATCCAAGTCTTCCAGTAAATCTAGTTCTTCCAGAAAAATCTAGATCTTCCAGTCAATCAGTGTCTTCCAGAAAGAAATCCAGGTCTTCCAGTCAATCAGTGTCTTCCAGAAAGAAATCCAGGTCTTCCAGTCAGTCAGTGTCTTCCAGAAAAATCTACGTCTTCCACCAAATCCAGGTCTTCCAGTCAATCCACATCTTCCGGAAAAAATCCAGGTCTTCCAGCCAATATATGTCTTCCTGAAGATCCACGTCTTCCAGAAAATCCATGTCTTCCAGAAAATCCATGTCTTCCAGTAACCTCCCAGTCTTCCAGAAAATCCACGTCTTCCCAACAATCCAAGTCTTCCGGATAATTTGGGTCTTCCTGAAAATCTACGTCTTCCAAAAAAGCCATGTCTTCCAGAAAATCCACATCTTCCAATGGCCTCCAGGTCTTCCAGACTATCCATGTCTTCCAGAAAATCCTTGTCTTCCCTTAAATCTATAGCTTCCAAAAAATCCGGGTCTTCCAGGAAATCCGTGTCTTCCAGCAAGTCCACGTCTTCCAACAAAGCCATGTCTTCCAGACTATCCATGTCTTCCAGAAAATCCTTGTCTTCCCTCAAATCCATAGCTTCCGAAAAATCCAGGTCTTCCAGGAAATCCGTGTCTTCCAGCAAATCCACGTCTTCCAACAAAGCCATGTCTTCCATCAAATTAATGTCTTCCAGCCTACTTGTGTCTTCCAACAAAGGTACGTCTTCCAACAAAGGTACGTCTTCCAACAAAGGTATGTCTTCCAACAAAGGTACGTCTTCCAGAAAATCCACGTCTTCCAACCAAGCCATGTCTTCCAGAAAATCCACGTCTTCCAGAAAATATATGTCTTCCAACTAAGCTACGTCTTCCAACAAATCCATGTCTTCCTATATCTCCAGGTCTTCCAGCATCTCCAGGGCTTCCAGCATCTGCTCGTCTTCCAACATCTCCACGTCTTCCAGCATCTCTGTGTCTTCCAGCATCTTCATGTCTTCCAACAACTACCCAGTCTTCCATCAACTGGCTCAATATCCATGTCTTCCAACGTCTCCAGTGTGCTGATCTTCTGACATTCAGGTCTTCCAGTGTCTGCAATATCCAG Alzheimer¡¯s disease 28296235 The circular RNA ciRS-7 promotes APP and BACE1 degradation in an NF-κB-dependent manner. Shi Z, Chen T, Yao Q, Zheng L, Zhang Z, Wang J, Hu Z, Cui H, Han Y, Han X, Zhang K, Hong W. FEBS J. 2017 ciRS-7, which is highly expressed in the human brain, is down-regulated in the brain of people with AD. APP reduces the level of ciRS-7. qRT-PCR HEK293T, SH-SY5Y We have found that ciRS-7 is not involved in the regulation of APP and BACE1 gene expression, but instead reduces the protein levels of APP and BACE1 by promoting their degradation via the proteasome and lysosome. Consequently, overexpression of ciRS-7 reduces the generation of Ab, indicating a potential neuroprotective role of ciRS-7. Our data also suggest that ciRS-7 modulates APP and BACE1 levels in a nuclear factor-kapaB (NF-kapaB)-dependent manner: ciRS-7 expression inhibits translation of NF-kapaB and induces its cytoplasmic localization, thus derepressing expression of UCHL1, which promotes APP and BACE1 degradation. Additionally, we demonstrated that APP reduces the level of ciRS-7, revealing a mutual regulation of ciRS-7 and APP. loss of function, gain of function HEK293T, SH-SY5Y APP reduces the level of ciRS-7. ciRS-7 circRNA homo sapiens CDR1 hsa_circ_0001946 CDR1as GGTTTCCGATGGCACCTGTGTCAAGGTCTTCCAACAACTCCGGGTCTTCCAGCGACTTCAAGTCTTCCAATAATCTCAAGGTCTTCCAGATAATCCTGAGCTTCCAGAAAATCCACATCTTCCAGACAATCCATGTCTTCCGGACAATCCATGTCTTCCAAGAAGCTCCAAGTCTTCCAGTAAATCAAGTCTTCCAGCAAATCCAGTCTTCCAGCAATTACTGGTCTTCCACCAAATCCAGATCTTCCAGGAAAATCCACGTCTTCCAGGAAATCCATGTCTTCCAATAATTTCAAGGTCTTCCATCAAATACAGATCTTCCAGCTAATCCATGTCTTCCAGAAAAATCTGTGTCTTCCACCAAATCCAAGTCTTCCAGTAAATCTAGTTCTTCCAGAAAAATCTAGATCTTCCAGTCAATCAGTGTCTTCCAGAAAGAAATCCAGGTCTTCCAGTCAATCAGTGTCTTCCAGAAAGAAATCCAGGTCTTCCAGTCAGTCAGTGTCTTCCAGAAAAATCTACGTCTTCCACCAAATCCAGGTCTTCCAGTCAATCCACATCTTCCGGAAAAAATCCAGGTCTTCCAGCCAATATATGTCTTCCTGAAGATCCACGTCTTCCAGAAAATCCATGTCTTCCAGAAAATCCATGTCTTCCAGTAACCTCCCAGTCTTCCAGAAAATCCACGTCTTCCCAACAATCCAAGTCTTCCGGATAATTTGGGTCTTCCTGAAAATCTACGTCTTCCAAAAAAGCCATGTCTTCCAGAAAATCCACATCTTCCAATGGCCTCCAGGTCTTCCAGACTATCCATGTCTTCCAGAAAATCCTTGTCTTCCCTTAAATCTATAGCTTCCAAAAAATCCGGGTCTTCCAGGAAATCCGTGTCTTCCAGCAAGTCCACGTCTTCCAACAAAGCCATGTCTTCCAGACTATCCATGTCTTCCAGAAAATCCTTGTCTTCCCTCAAATCCATAGCTTCCGAAAAATCCAGGTCTTCCAGGAAATCCGTGTCTTCCAGCAAATCCACGTCTTCCAACAAAGCCATGTCTTCCATCAAATTAATGTCTTCCAGCCTACTTGTGTCTTCCAACAAAGGTACGTCTTCCAACAAAGGTACGTCTTCCAACAAAGGTATGTCTTCCAACAAAGGTACGTCTTCCAGAAAATCCACGTCTTCCAACCAAGCCATGTCTTCCAGAAAATCCACGTCTTCCAGAAAATATATGTCTTCCAACTAAGCTACGTCTTCCAACAAATCCATGTCTTCCTATATCTCCAGGTCTTCCAGCATCTCCAGGGCTTCCAGCATCTGCTCGTCTTCCAACATCTCCACGTCTTCCAGCATCTCTGTGTCTTCCAGCATCTTCATGTCTTCCAACAACTACCCAGTCTTCCATCAACTGGCTCAATATCCATGTCTTCCAACGTCTCCAGTGTGCTGATCTTCTGACATTCAGGTCTTCCAGTGTCTGCAATATCCAG Acute Myocardial Infarction 26928231 Reciprocal Changes of Circulating Long Non-Coding RNAs ZFAS1 and CDR1AS Predict Acute Myocardial Infarction. Zhang Y, Sun L, Xuan L, Pan Z, Li K, Liu S, Huang Y, Zhao X, Huang L, Wang Z, Hou Y, Li J, Tian Y, Yu J, Han H, Liu Y, Gao F, Zhang Y, Wang S, Du Z, Lu Y, Yang B. Sci Rep. 2016 CDR1AS showed markedly higher level in AMI (2.18 ¡À 0.24) than in control populations qRT-PCR Human and mouse blood samples CDR1AS was positively correlated with AST, LDH, and CK. C57BL/6 mice Human Blood Samples ciRS-7 circRNA homo sapiens CDR1 hsa_circ_0001946 CDR1as GGTTTCCGATGGCACCTGTGTCAAGGTCTTCCAACAACTCCGGGTCTTCCAGCGACTTCAAGTCTTCCAATAATCTCAAGGTCTTCCAGATAATCCTGAGCTTCCAGAAAATCCACATCTTCCAGACAATCCATGTCTTCCGGACAATCCATGTCTTCCAAGAAGCTCCAAGTCTTCCAGTAAATCAAGTCTTCCAGCAAATCCAGTCTTCCAGCAATTACTGGTCTTCCACCAAATCCAGATCTTCCAGGAAAATCCACGTCTTCCAGGAAATCCATGTCTTCCAATAATTTCAAGGTCTTCCATCAAATACAGATCTTCCAGCTAATCCATGTCTTCCAGAAAAATCTGTGTCTTCCACCAAATCCAAGTCTTCCAGTAAATCTAGTTCTTCCAGAAAAATCTAGATCTTCCAGTCAATCAGTGTCTTCCAGAAAGAAATCCAGGTCTTCCAGTCAATCAGTGTCTTCCAGAAAGAAATCCAGGTCTTCCAGTCAGTCAGTGTCTTCCAGAAAAATCTACGTCTTCCACCAAATCCAGGTCTTCCAGTCAATCCACATCTTCCGGAAAAAATCCAGGTCTTCCAGCCAATATATGTCTTCCTGAAGATCCACGTCTTCCAGAAAATCCATGTCTTCCAGAAAATCCATGTCTTCCAGTAACCTCCCAGTCTTCCAGAAAATCCACGTCTTCCCAACAATCCAAGTCTTCCGGATAATTTGGGTCTTCCTGAAAATCTACGTCTTCCAAAAAAGCCATGTCTTCCAGAAAATCCACATCTTCCAATGGCCTCCAGGTCTTCCAGACTATCCATGTCTTCCAGAAAATCCTTGTCTTCCCTTAAATCTATAGCTTCCAAAAAATCCGGGTCTTCCAGGAAATCCGTGTCTTCCAGCAAGTCCACGTCTTCCAACAAAGCCATGTCTTCCAGACTATCCATGTCTTCCAGAAAATCCTTGTCTTCCCTCAAATCCATAGCTTCCGAAAAATCCAGGTCTTCCAGGAAATCCGTGTCTTCCAGCAAATCCACGTCTTCCAACAAAGCCATGTCTTCCATCAAATTAATGTCTTCCAGCCTACTTGTGTCTTCCAACAAAGGTACGTCTTCCAACAAAGGTACGTCTTCCAACAAAGGTATGTCTTCCAACAAAGGTACGTCTTCCAGAAAATCCACGTCTTCCAACCAAGCCATGTCTTCCAGAAAATCCACGTCTTCCAGAAAATATATGTCTTCCAACTAAGCTACGTCTTCCAACAAATCCATGTCTTCCTATATCTCCAGGTCTTCCAGCATCTCCAGGGCTTCCAGCATCTGCTCGTCTTCCAACATCTCCACGTCTTCCAGCATCTCTGTGTCTTCCAGCATCTTCATGTCTTCCAACAACTACCCAGTCTTCCATCAACTGGCTCAATATCCATGTCTTCCAACGTCTCCAGTGTGCTGATCTTCTGACATTCAGGTCTTCCAGTGTCTGCAATATCCAG 26138677 Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis. Li Y, Zheng Q, Bao C, Li S, Guo W, Zhao J, Chen D, Gu J, He X, Huang S. Cell Res. 2015 circRNAs are enriched and stable in exosomes RNA-seq, qRT-PCR MHCC-LM3, HeLa, MCF-7, SMCC-7721, HCT-116, MGC-803, NCI-H1299, HEK-293T cells and cell-derived exosomes may serve as a potential biomarker for cancer detection gain of function SMCC-7721 BALB/c-nu/nu mice miR-7 circRNA-miRNA ciRS-7 circRNA homo sapiens CDR1 hsa_circ_0001946 CDR1as GGTTTCCGATGGCACCTGTGTCAAGGTCTTCCAACAACTCCGGGTCTTCCAGCGACTTCAAGTCTTCCAATAATCTCAAGGTCTTCCAGATAATCCTGAGCTTCCAGAAAATCCACATCTTCCAGACAATCCATGTCTTCCGGACAATCCATGTCTTCCAAGAAGCTCCAAGTCTTCCAGTAAATCAAGTCTTCCAGCAAATCCAGTCTTCCAGCAATTACTGGTCTTCCACCAAATCCAGATCTTCCAGGAAAATCCACGTCTTCCAGGAAATCCATGTCTTCCAATAATTTCAAGGTCTTCCATCAAATACAGATCTTCCAGCTAATCCATGTCTTCCAGAAAAATCTGTGTCTTCCACCAAATCCAAGTCTTCCAGTAAATCTAGTTCTTCCAGAAAAATCTAGATCTTCCAGTCAATCAGTGTCTTCCAGAAAGAAATCCAGGTCTTCCAGTCAATCAGTGTCTTCCAGAAAGAAATCCAGGTCTTCCAGTCAGTCAGTGTCTTCCAGAAAAATCTACGTCTTCCACCAAATCCAGGTCTTCCAGTCAATCCACATCTTCCGGAAAAAATCCAGGTCTTCCAGCCAATATATGTCTTCCTGAAGATCCACGTCTTCCAGAAAATCCATGTCTTCCAGAAAATCCATGTCTTCCAGTAACCTCCCAGTCTTCCAGAAAATCCACGTCTTCCCAACAATCCAAGTCTTCCGGATAATTTGGGTCTTCCTGAAAATCTACGTCTTCCAAAAAAGCCATGTCTTCCAGAAAATCCACATCTTCCAATGGCCTCCAGGTCTTCCAGACTATCCATGTCTTCCAGAAAATCCTTGTCTTCCCTTAAATCTATAGCTTCCAAAAAATCCGGGTCTTCCAGGAAATCCGTGTCTTCCAGCAAGTCCACGTCTTCCAACAAAGCCATGTCTTCCAGACTATCCATGTCTTCCAGAAAATCCTTGTCTTCCCTCAAATCCATAGCTTCCGAAAAATCCAGGTCTTCCAGGAAATCCGTGTCTTCCAGCAAATCCACGTCTTCCAACAAAGCCATGTCTTCCATCAAATTAATGTCTTCCAGCCTACTTGTGTCTTCCAACAAAGGTACGTCTTCCAACAAAGGTACGTCTTCCAACAAAGGTATGTCTTCCAACAAAGGTACGTCTTCCAGAAAATCCACGTCTTCCAACCAAGCCATGTCTTCCAGAAAATCCACGTCTTCCAGAAAATATATGTCTTCCAACTAAGCTACGTCTTCCAACAAATCCATGTCTTCCTATATCTCCAGGTCTTCCAGCATCTCCAGGGCTTCCAGCATCTGCTCGTCTTCCAACATCTCCACGTCTTCCAGCATCTCTGTGTCTTCCAGCATCTTCATGTCTTCCAACAACTACCCAGTCTTCCATCAACTGGCTCAATATCCATGTCTTCCAACGTCTCCAGTGTGCTGATCTTCTGACATTCAGGTCTTCCAGTGTCTGCAATATCCAG cholangiocarcinoma (CCA) 29424892 A novel prognostic biomarker for cholangiocarcinoma: circRNA Cdr1as. Jiang XM, Li ZL, Li JL, Xu Y, Leng KM, Cui YF, Sun DJ. Eur Rev Med Pharmacol Sci. 2018 CircRNA Cdr1as Expression is Upregulated in CCA qRT-PCR paired tumor and adjacent normal tissues The overexpression of Cdr1as was observed to be closely correlated with advanced TNM stage, lymph node invasion, and postoperative recurrence. The overall survival of CCA patients with high Cdr1as expression was significantly worse than that of patients with low Cdr1as expression. CCA tumor samples hsa_circ_0001946 circRNA homo sapiens CDR1 hsa_circ_0001946 CDR1as GGTTTCCGATGGCACCTGTGTCAAGGTCTTCCAACAACTCCGGGTCTTCCAGCGACTTCAAGTCTTCCAATAATCTCAAGGTCTTCCAGATAATCCTGAGCTTCCAGAAAATCCACATCTTCCAGACAATCCATGTCTTCCGGACAATCCATGTCTTCCAAGAAGCTCCAAGTCTTCCAGTAAATCAAGTCTTCCAGCAAATCCAGTCTTCCAGCAATTACTGGTCTTCCACCAAATCCAGATCTTCCAGGAAAATCCACGTCTTCCAGGAAATCCATGTCTTCCAATAATTTCAAGGTCTTCCATCAAATACAGATCTTCCAGCTAATCCATGTCTTCCAGAAAAATCTGTGTCTTCCACCAAATCCAAGTCTTCCAGTAAATCTAGTTCTTCCAGAAAAATCTAGATCTTCCAGTCAATCAGTGTCTTCCAGAAAGAAATCCAGGTCTTCCAGTCAATCAGTGTCTTCCAGAAAGAAATCCAGGTCTTCCAGTCAGTCAGTGTCTTCCAGAAAAATCTACGTCTTCCACCAAATCCAGGTCTTCCAGTCAATCCACATCTTCCGGAAAAAATCCAGGTCTTCCAGCCAATATATGTCTTCCTGAAGATCCACGTCTTCCAGAAAATCCATGTCTTCCAGAAAATCCATGTCTTCCAGTAACCTCCCAGTCTTCCAGAAAATCCACGTCTTCCCAACAATCCAAGTCTTCCGGATAATTTGGGTCTTCCTGAAAATCTACGTCTTCCAAAAAAGCCATGTCTTCCAGAAAATCCACATCTTCCAATGGCCTCCAGGTCTTCCAGACTATCCATGTCTTCCAGAAAATCCTTGTCTTCCCTTAAATCTATAGCTTCCAAAAAATCCGGGTCTTCCAGGAAATCCGTGTCTTCCAGCAAGTCCACGTCTTCCAACAAAGCCATGTCTTCCAGACTATCCATGTCTTCCAGAAAATCCTTGTCTTCCCTCAAATCCATAGCTTCCGAAAAATCCAGGTCTTCCAGGAAATCCGTGTCTTCCAGCAAATCCACGTCTTCCAACAAAGCCATGTCTTCCATCAAATTAATGTCTTCCAGCCTACTTGTGTCTTCCAACAAAGGTACGTCTTCCAACAAAGGTACGTCTTCCAACAAAGGTATGTCTTCCAACAAAGGTACGTCTTCCAGAAAATCCACGTCTTCCAACCAAGCCATGTCTTCCAGAAAATCCACGTCTTCCAGAAAATATATGTCTTCCAACTAAGCTACGTCTTCCAACAAATCCATGTCTTCCTATATCTCCAGGTCTTCCAGCATCTCCAGGGCTTCCAGCATCTGCTCGTCTTCCAACATCTCCACGTCTTCCAGCATCTCTGTGTCTTCCAGCATCTTCATGTCTTCCAACAACTACCCAGTCTTCCATCAACTGGCTCAATATCCATGTCTTCCAACGTCTCCAGTGTGCTGATCTTCTGACATTCAGGTCTTCCAGTGTCTGCAATATCCAG pancreatic ductal adenocarcinoma 27997903 Circular RNA Expression Profile of Pancreatic Ductal Adenocarcinoma Revealed by Microarray. Li H, Hao X, Wang H, Liu Z, He Y, Pu M, Zhang H, Yu H, Duan J, Qu S. Cell Physiol Biochem. 2016 up microarray, qRT-PCR PDAC samples and corresponding normal tissues hsa_circ_0001953 circRNA homo sapiens ZFY hsa_circ_0001953 hsa_circ_001871 GAGCTGTGACTAATGAGAATTAAAGGCCATGGATGAAGATGAATTTGAATTGCAGCCACAAGAGCCAAACTCATTTTTTGATGGAATAGGAGCTGATGCTACACACATGGATGGTGATCAGATTGTTGTGGAAATACAAGAAGCAGTTTTTGTTTCTAATATTGTGGATTCTGACATAACTGTGCATAACTTTGTTCCTGATGACCCAGACTCAGTTGTAATCCAAGATGTTGTTGAAGATGTTGTCATAGAGGAGGATGTTCAGTGCTCAGATATCTTAGAAGAGGCAGATGTATCTGAAAATGTCATCATTCCTGAGCAAGTGCTGGACTCAGATGTAACTGAAGAAGTTTCTTTACCACACTGCACAGTCCCAGATGATGTTTTAGCTTCTGACATTACTTCAACCTCAATGTCTATGCCAGAACATGTTTTAACGAGTGAATCCATGCATGTGTGTGACATTGGACATGTTGAACATATGGTGCATGATAGTGTAGTGGAAGCAGAAATCATTACTGATCCTCTGACGAGTGACATAGTTTCAGAAGAAGTATTGGTAGCAGACTGTGCCCCTGAAGCAGTCATAGATGCCAGCGGGATCTCAGTGGACCAGCAAGATAATGACAAAGCCAGCTGTGAGGACTACCTAATGATTTCGT male infertile diseases 27958373 Identification and characterization of human testis derived circular RNAs and their existence in seminal plasma. Dong WW, Li HM, Qing XR, Huang DH, Li HG. Sci Rep. 2016 To validate these predicted circRNAs, 55 circRNAs of different abundance and lengths were randomly chosen for subsequent RT-PCR validation. Divergent primers were designed for circRNA detection. Among the 55 circRNAs, 30 of them could be specifically amplified. qRT-PCR human testis hsa_circ_0001982 circRNA homo sapiens RNF111 hsa_circ_0001982 GCTTTCCTTAAAGTTTCCCATGTCTCAATGGACTCCTGAATATAACGAGCTCTACACCTTAAAAGTGGATATGAAGAGTGAGATTCCTTCTGATGCACCAAAGACACAGGAGAGTCTGAAAGGGATCCTTTTGCATCCAGAGCCCATTGGGGCAGCCAAAAGTTTTCCTGCAGGAGTTGAGATGATTAATAGTAAAGTGGGGAATGAATTCTCTCACCTGTGTGATGATTCTCAAAAGCAAGAGAAGGAAATGAATGGTAACCAGCAAGAACAAGAAAAAAGTCTCGTTGTGAGGAAAAAACGCAAAAGCCAGCAGGCTGGCCCTTCGTATGTGCAGAATTGTGTTAAAGAAAACCAGGGAATATTAGGACTGAGGCAACACCTAGGGACACCAAGTGATGAAGATAATGATTCCTCTTTTAGTGATTGTCTTTCTTCTCCTTCATCTAGTCTGCATTTTGGAGATTCTGATACTGTGACTTCAGATGAGGATAAAGAAGTCTCTGTAAGACATTCCCAGACCATTTTGAATGCTAAAAGTAGAAGCCATAGTGCACGGTCTCATAAGTGGCCTCGGACTGAGACAGAATCTGTATCGGGATTGTTAATGAAAAGACCCTGTTTACATGGCAGTTCGTTACGGAGACTTCCATGCAGAAAGAGATTTGTAAAAAATAATTCCTCACAGAGGACACAGAAACAAAAAGAGAGGATATTAATGCAGAGGAAGAAACGAGAAGTGTTAGCTCGAAGAAAATATGCCTTGCTACCTAGTTCTAGTAGTTCCAGTGAGAATGACCTCAGCAGTGAATCCTCTTCTAGCTCATCAACTGAAGGAGAAGAAGATTTGTTTGTTTCTGCCAGTGAAAACCACCAAAACAATCCAGCTGTTCCCTCAG breast cancer 28933584 Circular RNA hsa_circ_0001982 Promotes Breast Cancer Cell Carcinogenesis Through Decreasing miR-143. Tang YY, Zhao P, Zou TN, Duan JJ, Zhi R, Yang SY, Yang DC, Wang XL. DNA Cell Biol. 2017 hsa_circ_0001982 was markedly overexpressed in breast cancer tissue and cell lines microarray, qRT-PCR breast cancer tissues and adjacent normal tissues, HBL-100, MDA-MB-231, MCF-7, MDAMB-468, MDA-MB-435s hsa_circ_0001982 knockdown suppressed breastcancer cell proliferation and invasion and induced apoptosis by targeting miR-143. loss of function MCF7 miR-143 circRNA-miRNA MCF7 luciferase reporter assay Bioinformatics analysis predicted that miR-143 acted as target of hsa_circ_0001982, which was confirmed by Dual-luciferase reporter assay. hsa_circ_0002024 circRNA homo sapiens NAB1 hsa_circ_0002024 GTTAAACCCATCCAGAGTAATGGCTGCGGCCTTACCCAGGACCCTGGGGGAGTTGCAGCTGTATAGAATATTACAAAAAGCCAATCTACTTTCTTATTTTGATGCCTTTATCCAACAAGGTGGTGATGATGTCCAGCAACTCTGTGAAGCAGGAGAAGAGGAGTTTTTGGAAATCATGGCACTCGTGGGCATGGCTAGCAAGCCCCTTCATGTTAGAAGGCTGCAGAAGGCTTTGAGAGACTGGGTCACAAACCCTGGGCTTTTCAATCAGCCACTGACTTCCCTTCCTGTCAGTAGCATACCCATCTATAAATTACCAGAGGGATCACCAACATGGCTGGGAATATCCTGCAGTAGTTATGAAAGGAGTAGCAATGCCCGGGAACCTCATTTAAAAATCCCCAAATGTGCTGCCACCACCTGTGTGCAGAGCTTGGGACAGGGGAAGTCAGATGTGGTTGGGAGCCTAGCACTGCAGAGTGTTGGTGAGTCCAGACTCTGGCAAGGCCACCATGCCACTGAGAGCGAGCACAGCCTCTCCCCAGCAGACCTGGGCTCCCCCGCGTCCCCAAAGGAGAGCAGTGAGGCGCTGGATGCTGCTGCTGCGCTCTCTGTGGCTGAGTGTGTGGAGCGGATGGCCCCCACACTGCCAAAAAGTGACTTGAATGAAGTGAAAGAGCTGCTAAAAACCAACAAGAAGTTGGCCAAAATGATTGGTCACATCTTTGAGATGAACGATGATGATCCACACAAAGAGGAGGAAATTCGGAAATACAGTGCAATATATGGCAGATTTGACTCAAAGAGGAAGGATGGGAAACATCTCACACTTCATGAGCTCACTGTTAATGAAGCGGCTGCTCAACTCTGTGTGAAGGATAATGCCCTGCTGACAAGAAGAGATGAGCTTTTTGCCTTGGCTCGACAGATTTCTCGAGAAGTCACCTATAAATATACTTACAGAACCACCAAGTCAAAATGTGGAGAAAGAGATGAATTATCCCCAAAGAGAATTAAAGTGGAG bladder cancer 29151929 Identification of circular RNA signature in bladder cancer. Yang X, Yuan W, Tao J, Li P, Yang C, Deng X, Zhang X, Tang J, Han J, Wang J, Li P, Lu Q, Gu M. J Cancer. 2017 The level of hsa_circ_0002024 in cancerous tissues were significantly reduced compared with noncancerous tissues. RNA-seq, qRT-PCR bladder cancer and adjacent non-tumour tissue hsa_circRNA_104565 circRNA homo sapiens PSD3 hsa_circ_0002111 CAATGCTGGGGTGAAAACAACACGGCTAGAAGCTCATTCTGAAATGGGGAGCACTGAAATTTTGGAAAAGGAGACCCCAGAAAATCTCAGTAATGGTACCAGCAGCAATGTGGAAGCAGCCAAAAGGTTGGCCAAACGCCTTTATCAGCTGGACAGATTCAAAAGATCAGATGTTGCAAAACACCTTGGCAAGAACAACGAATTTAGCAAACTAGTTGCAGAAGAATATCTGAAGTTTTTTGATTTTACAGGAATGACGCTGGATCAGTCACTCAGGTATTTCTTTAAAGCATTCTCTCTTGTGGGAGAAACTCAAGAACGAGAGAGAGTTTTAATACACTTCTCCAATAGATATTTTTATTGTAACCCAGATACCATTGCTTCACAAGATGGAGTCCATTGCCTTACCTGTGCAATAATGCTTCTTAATACCGATCTACATGGCCACAATATTGGAAAGAAGATGACCTGTCAGGAGTTCATTGCAAATCTGCAAGGGGTAAATGAGGGTGTTGATTTCTCCAAGGATCTGCTGAAA papillary thyroid carcinoma 28288173 Microarray profiling of circular RNAs in human papillary thyroid carcinoma. Peng N, Shi L, Zhang Q, Hu Y, Wang N, Ye H. PLoS One. 2017 upregulated microarray, qRT-PCR PTC tumors, matching contralateral normal samples, benign thyroid lesions (i.e., follicular adenoma samples and multinodular goiter samples) hsa-miR-450b-5p, hsa-miR-205-3p, hsa-miR-103a-2-5p, hsa-miR-95-5p, hsa-miR-329-5p circRNA-miRNA predicted hsa_circ_0002113 circRNA homo sapiens IFNGR2 hsa_circ_0002113 CACCGACAGTAAATGGTTCACGGCCGACATCATGTCCATAGGGGTGAATTGTACACAGATCACAGCAACAGAGTGTGACTTCACTGCCGCCAGTCCCTCAGCAGGCTTCCCAATGGATTTCAATGTCACTCTACGCCTTCGAGCTGAGCTGGGAGCACTCCATTCTGCCTGGGTGACAATGCCTTGGTTTCAACACTATCGGAATGTGACTGTCGGGCCTCCAGAAAACATTGAGGTGACCCCAGGAGAAGGCTCCCTCATCATCAGGTTCTCCTCTCCCTTTGACATCGCTGATACCTCCACGGCCTTTTTTTGTTATTATGTCCATTACTGGGAAAAAGGAGGAATCCAACAGGTCAAAGGCCCTTTCAGAAGCAACTCCATTTCATTGGATAACTTAAAACCCTCCAGAGTGTACTGTTTACAAGTCCAGGCACAACTGCTTTGGAACAAAAGTAACATCTTTAGAGTCGGGCATTTAAGCAACATATCTTGCTACGAAACAATGGCAGATGCCTCCACTGAGCTTCAGCAAGTCATCCTGATCTCCGTGGGAACATTTTCGTTGCTGTCGGTGCTGGCAGGAGCCTGTTTCTTCCTGGTCCTGAAATATAGAGGCCTGATTAAATACTGGTTTCACACTCCACCAAGCATCCCATTACAGATAGAAGAG Active Pulmonary Tuberculosis 29248507 Potential Diagnostic Power of Blood Circular RNA Expression in Active Pulmonary Tuberculosis. Qian Z, Liu H, Li M, Shi J, Li N, Zhang Y, Zhang X, Lv J, Xie X, Bai Y, Ge Q, Ko EA, Tang H, Wang T, Wang X, Wang Z, Zhou T, Gu W. EBioMedicine. 2018 Upregulated in TB patients compared to healthy controls. RNA-seq, microarray, qRT-PCR healthy controls and TB patients hsa_circ_0002113 circRNA homo sapiens IFNGR2 hsa_circ_0002113 CACCGACAGTAAATGGTTCACGGCCGACATCATGTCCATAGGGGTGAATTGTACACAGATCACAGCAACAGAGTGTGACTTCACTGCCGCCAGTCCCTCAGCAGGCTTCCCAATGGATTTCAATGTCACTCTACGCCTTCGAGCTGAGCTGGGAGCACTCCATTCTGCCTGGGTGACAATGCCTTGGTTTCAACACTATCGGAATGTGACTGTCGGGCCTCCAGAAAACATTGAGGTGACCCCAGGAGAAGGCTCCCTCATCATCAGGTTCTCCTCTCCCTTTGACATCGCTGATACCTCCACGGCCTTTTTTTGTTATTATGTCCATTACTGGGAAAAAGGAGGAATCCAACAGGTCAAAGGCCCTTTCAGAAGCAACTCCATTTCATTGGATAACTTAAAACCCTCCAGAGTGTACTGTTTACAAGTCCAGGCACAACTGCTTTGGAACAAAAGTAACATCTTTAGAGTCGGGCATTTAAGCAACATATCTTGCTACGAAACAATGGCAGATGCCTCCACTGAGCTTCAGCAAGTCATCCTGATCTCCGTGGGAACATTTTCGTTGCTGTCGGTGCTGGCAGGAGCCTGTTTCTTCCTGGTCCTGAAATATAGAGGCCTGATTAAATACTGGTTTCACACTCCACCAAGCATCCCATTACAGATAGAAGAG breast cancer 28803498 Screening circular RNA related to chemotherapeutic resistance in breast cancer. Gao D, Zhang X, Liu B, Meng D, Fang K, Guo Z, Li L. Epigenomics. 2017 up microarray, qRT-PCR MCF-7, ADM-resistant cell lines (MCF-7/ADM) circHECW2 circRNA homo sapiens HECW2 hsa_circ_0002150 GCATTCTTTGTGGACCACAACTCCCGCACCACCACTTTCATTGATCCCCGGCTCCCACTTCAGAGCAGTAGACCCACAAGTGCGCTGGTTCATCGGCAACACCTGACAAGGCAACGCAGCCACAGTGCGGGTGAGGTAGGAGAAGATTCTCGACATGCAGGACCACCAGTTCTTCCCAGGCCATCCAGTACATTCAATACAGTCAGTAGGCCACAGTACCAGGACATGGTTCCAGTGGCTTACAATGACAAGATTGTTGCATTTCTACGTCAACCCAATATCTTTGAAATTCTACAGGAGCGTCAACCTGATCTTACCAGGAATCACTCACTCAG 29260931 Engagement of circular RNA HECW2 in the nonautophagic role of ATG5 implicated in the endothelial-mesenchymal transition. Yang L, Han B, Zhang Y, Bai Y, Chao J, Hu G, Yao H. Autophagy. 2018 The treatment of HBMECs with Meth or LPS significantly increased the circHECW2 expression in HBMECs. This finding was further confirmed in LPS-treated mice as there was an increased expression of circHecw2 in the hippocampus. qRT-PCR human brain microvascular endothelial cells, mice hippocampus circHECW2 regulated the EndoMT by directly binding to MIR30D, a significantly downregulated miRNA from miRNA profiling, which subsequently caused an increased expression of ATG5. loss of function human brain microvascular endothelial cells the hippocampus of C57BL/6J mice miR-30d-5p circRNA-miRNA human brain microvascular endothelial cells RNA pull-down An enrichment of circHECW2 in the MIR30D-captured fraction compared with that observed following the introduction of mutations that disrupt base paring between circHECW2 and MIR30D. By applying a biotin-labeled specific probe, MIR30D was pulled down by circHECW2. ATG5 hsa_circ_0002161 circRNA homo sapiens GSPT1 hsa_circ_0002161 TAGAAAATGGAGAGACAGAAATGTCTCCAGAAGAATCATGGGAGCACAAAGAAGAAATAAGTGAAGCAGAGCCAGGGGGTGGTTCCTTGGGAGATGGAAGGCCGCCAGAGGAAAGTGCCCATGAAATGATGGAGGAGGAAGAGGAAATCCCAAAACCTAAGTCTGTGGTTGCACCGCCAGGTGCTCCTAAGAAAGAGCATGTAAATGTAGTATTCATTGGGCACGTAGATGCTGGCAAGTCAACCATTGGAGGACAAATAAT essential hypertension 29526758 A potential risk factor of essential hypertension in case-control study: Circular RNA hsa_circ_0037911. Bao X, Zheng S, Mao S, Gu T, Liu S, Sun J, Zhang L. Biochem Biophys Res Commun. 2018 hsa_circ_0002161 have no significant difference in different state. qRT-PCR blood samples of essential hypertension cases and controls hsa_circ_0002260 circRNA homo sapiens PAPD4 hsa_circ_0002260 TTGAGTCAGCAGATACTGGAGTTATTTGAAACATGTCAGCAGCAAATAAGTGATTTAAAGAAGAAAGAACTCTGTCGAACACAGCTGCAGAGAGAAATTCAGCTGTTATTTCCACAAAGCAGACTTTTTTTGGTTGGGTCCTCTTTAAATGGATTTGGTACCCGGAGCAGTGATGGTGATTTATGCCTAGTTGTTAAGGAAGAACCATGTTTTTTTCAGGTAAATCAGAAGACTGAAGCACGGCATATACTCACCTTAGTCCATAAACACTTCTGTACTAGACTTTCGGGCTACATTGAGAGACCTCAGCTGATTCGAGCAAAAGTGCCAATTGTGAAGTTCAGGGATAAAGTCAGTTGTGTGGAGTTTGACTTGAATGTAAACAATATTGTTGGAATAAGAAACACATTCCTTCTCAGAACTTATGCATACCTTGAAAATCGAGTTCGTCCGTTAGTGCTGGTGATTAAGAAGTGGGCAAGTCACCATCAGATAAATGATGCCAGTCGTGGTACTTTAAGCAGCTATAGTCTTGTATTGATGGTTTTGCACTATTTACAAACCCTACCTGAACCCATCCTTCCATCCCTCCAAAAAATTTACCCAGAGTCTTTTAGTCCTGCTATACAGCTGCACCTTGTACATCAAGCTCCATGTAATGTTCCTCCTTACCTCTCAAAGAATGAATCAAACCTTGGGGACCTCTTACTGGGCTTTCTTAAATATTATGCTACAGAATTTGA hypopharyngeal squamous cell carcinoma 28514762 Novel circular RNA expression profiles reflect progression of patients with hypopharyngeal squamous cell carcinoma. Cao S, Wei D, Li X, Zhou J, Li W, Qian Y, Wang Z, Li G, Pan X, Lei D. Oncotarget. 2017 down microarray, qRT-PCR Tumor tissues and paired adjacent normal tissues hsa_circ_0002322 circRNA homo sapiens WDR26 hsa_circ_0002322 AGGATGAAGTTTTTGCTGCTGCAGCAGAAGTACCTAGAATACCTGGAGGATGGCAAGGTCCTGGAGGCACTTCAAGTTCTACGCTGTGAATTGACGCCGCTGAAATACAATACAGAGCGCATTCATGTTCTTAGTGGGTATCTGATGTGTAGCCATGCAGAAGACCTACGTGCAAAAGCAGAATGGGAAGGCAAAGGGACAGCTTCCCGATCTAAACTATTGGATAAACTTCAGACCTATTTACCACCATCAGTGATGCTTCCCCCACGGCGTTTACAGACTCTCCTGCGGCAGGCGGTGGAACTACAAAGGGATCGGTGCCTATATCACAATACCAAACTTGATAATAATCTAGATTCTGTGTCTCTGCTTATAGACCATGTTTGTAGTAG male infertile diseases 27958373 Identification and characterization of human testis derived circular RNAs and their existence in seminal plasma. Dong WW, Li HM, Qing XR, Huang DH, Li HG. Sci Rep. 2016 To validate these predicted circRNAs, 55 circRNAs of different abundance and lengths were randomly chosen for subsequent RT-PCR validation. Divergent primers were designed for circRNA detection. Among the 55 circRNAs, 30 of them could be specifically amplified. qRT-PCR human testis hsa_circ_0002362 circRNA homo sapiens ASAP2 hsa_circ_0002362 ATTCAGAATATGAACAACATAATCTCCTTCCCTTTGGACAGTTTGCTGAAGGGGGACCTGAAAGGAGTGAAAGGGGATCTGAAAAAGCCTTTTGATAAAGCTTGGAAGGACTATGAAACAAAAATAACCAAGATAGAAAAGGAGAAAAAGGAACACGCCAAGCTCCATGGGATGATTCGGACTGAAATAAGCGGAGCGGAAATTGCCGAAGAGATGGAAAAGGAGAGGCGCTTCTTCCAGCTACAGATGTGCGAGTATCTGCTGAAGGTCAACGAAATCAAGATTAAAAAGGGAGTAGATTTACTTCAGAATCTGATCAAATACTTTCATGCCCAATGCAA Active Pulmonary Tuberculosis 29248507 Potential Diagnostic Power of Blood Circular RNA Expression in Active Pulmonary Tuberculosis. Qian Z, Liu H, Li M, Shi J, Li N, Zhang Y, Zhang X, Lv J, Xie X, Bai Y, Ge Q, Ko EA, Tang H, Wang T, Wang X, Wang Z, Zhou T, Gu W. EBioMedicine. 2018 Upregulated in TB patients compared to healthy controls. RNA-seq, microarray, qRT-PCR healthy controls and TB patients hsa_circ_0002423 circRNA homo sapiens TCONS_00010111 hsa_circ_0002423 GCTACGACACAAAGAGGAGCTGCTAACACCAGATGACCAACTCCTTTCCAGTTACGGACCATCCCGGTGATGAGACCTCCATATGTTGTCTGATGGCCGCAGTTCCTTGAGAAGCGTGGCCTGTCAGCCCAGCATCAGATGGTTCCATGCCAACCTCCTCCATGGCTAGGTGTTGGAGCGCCCCAGCTGCTGCCTCCCTGGTAGCTTTCATTAAAGGACTTTGCTTTTTTG hepatocellular carcinoma 29144509 Circular RNA expression is suppressed by androgen receptor (AR)-regulated adenosine deaminase that acts on RNA (ADAR1) in human hepatocellular carcinoma. Shi L, Yan P, Liang Y, Sun Y, Shen J, Zhou S, Lin H, Liang X, Cai X. Cell Death Dis. 2017 upregulated more than fivefold as revealed by circRNA microarray after AR knocking down in MHCC-101h cells microarray, qRT-PCR MHCC-97h, LM3 and LO7 cells hsa_circ_0002444 circRNA homo sapiens SAE1 hsa_circ_0002444 GCTGCGGGCCTCTCGGGTGCTTCTTGTCGGCTTGAAAGGACTTGGGGCTGAAATTGCCAAGAATCTCATCTTGGCAGGAGTGAAAGGACTGACCATGCTGGATCACGAACAGGTAACTCCAGAAGATCCCGGAGCTCAGTTCTTGATTCGTACTGGGTCTGTTGGCCGAAATAGGGCTGAAGCCTCTTTGGAGCGAGCTCAGAATCTCAACCCCATGGTGGATGTGAAGGTGGACACTGAGGATATAGAGAAGAAACCAGAGTCATTTTTCACTCAATTCGATGCTGTGTGTCTGACTTGCTGCTCCAGGGATGTCATAGTTAAAGTTGACCAGATCTGTCACAAAAATAGCATCAAGTTCTTTACAGGAGATGTTTTTGGCTACCATGGATACACATTTGCCAATCTAGGAGAGCATGAGTTTGTAGAGGAGAAAACTAAAGTTGCCAAAGTTAGCCAAGGAGTAGAAGATGGGCCCGACACCAAGAGAGCAAAACTTGATTCTTCTGAGACAACGATGGTCAAAAAG male infertile diseases 27958373 Identification and characterization of human testis derived circular RNAs and their existence in seminal plasma. Dong WW, Li HM, Qing XR, Huang DH, Li HG. Sci Rep. 2016 To validate these predicted circRNAs, 55 circRNAs of different abundance and lengths were randomly chosen for subsequent RT-PCR validation. Divergent primers were designed for circRNA detection. Among the 55 circRNAs, 30 of them could be specifically amplified. qRT-PCR human testis hsa_circ_0002495 circRNA homo sapiens RORA hsa_circ_0002495 ACCAACAATGACCAATTTGAGGACCGGCAGCAGTTCGTGGAGCACACTTTGAATAGTGTGGAGTTTACGTTATTCCCATCTGCACTGGCACAGTTACTCAGGTACTGTCTAATTCAGTGAACCCAACCTCCCACACCTGGCAGGAGGCTTATACACAGGGTTGCTCGATAAATTAGTTGAATTGAATGAATGAGTGAATAAATGAAAGCACAATAAATATTGAATGAATGAATAGATGATTGACTTGCTGAGCATATTTAAAACTCATAGTCCTTAGGAAGAATTTTCTTAATGAATAGCATGCCAAAGGGATTATAATTTTTTTATCTTTGCCTTTTATAAAATTCACTCATTTGCATTGCATATTAAGACCAATTCTTTTTCCTTAGTTTTTAAAACATTTTTATTTTCCGTCTGTGATAGCTAAATGGAGATAAGGTTTATACTTTCACAAAAATAAGGGCATACTTGGTAATATCTTCAGAAATAAGATAGGTGAGAATCTTAAGAGAACCCATACCTTATGCTTTAGTAAGAATCAGGATTTCTGAATTGAATAATTGCAAATTAGAGAGCAGAAGAAAGATATTATATACTTATATGTATATAAACTTGAACAGTTACCACTCAAGAGCCGTATTGAATTAACAAAAGTAAAAGTTTATTTTGTAGTGTTGCCATCAGTCACCAAATCAATGTTATTTGAAAAGAAAATCTCCCTACCCAGGTTTTCTTCCTCCTTGGGGAATACAGTGGTAATTCCCAGACTTGTGGTAAAGGAACCAGTGCACCAGTAAGCATGCCTTCCAATAATCACTGCATCTGTCTCAACAGAAGACAAAACCCAGCCCTACCTCCTCTAGAACTACTTAACGGAGGTTTTGAGATTTGAGGGTAAGCTATACACATTCTTCTCTGGAAATCACATACTGCTATTGTTCCTTCACCTTAAAAAGAGAAAATAAAATCAAATCGAGACCTGCAAACCATTCAGCCTCCTTCATTTTATTGTCTCACTATCTCTGGTCTCACTTTTCTGCAGACTTTCAAACTCACAACAATCTCTCCTTTTTTGGGGGAGGTCTACACTGCACAGTCATTCAGGCCAGGAACATTTGTGGAAGTCTCCTATGTGTGGAGCAGGAATACAGAAGGAAACAAGACACAAGGAAACAAACAACTCCACACATGTAGCTGACAGTTATTGCACAAGTCCAGGAGCGCCATATCCATGGGGAGAGAAGTGCAGGGCGTGCGGTGTATGAGGATTGCGTTGTGAATACTGATCCAGTTGGACGACAAGGAGCTCAGGGAAGGTTAGTGCAGGGAAGTGACATTTAAGGTCCAACAAGAAGGATGAGTAGAAATTTACCAGAGGAAGTAGTGGAAGAGAGTTCTAGGGCTTATGGATGACTCTATGACCATCAGGATCATCAGTATCACTCTCTTCCACACCCACATCTTGTCCCCCTGGCAGGTCTTCAAGGGCAATAACAGGCATTGAGCTGTCCTCGCCTATAACAGCAATGCCTCCTTCTGGAATATCTCTGGAAGGACCTGCCTGAGGCTGTTTTATAGTTATCATTTAAAAAAAATAAGAGTACACTCTAAAATGACAATATGAAGCATATTATAATAAATACACAAACCAGTAACATGGTCATTTATTATCATTACCATGTATTATATGCTGTACATAATTCTGTGTGTACTTTTTTTTTTTTTTGAGACTGAGTCTCGCTCTGTTGCCAGGCTGGAGTATAGAGGTGTGATCTCAGCTCACTGCAACCTCTGTCTCCTGGGTTCAAGTGATTCTCCACCTCAGCCTCCCTAGTATCTGGGACTACAGGTGTGCACCACCATGCCCCGCTAATTTTTGTATTTTTAGTAGAGGTGGGTTTCACCATGTTGGCCAGGATGGTCATGATCTCTTGACCTCGTGATCCGCCCACCTTGGCCTCCCAAAGTGGTGGGATTACAGGCGTGAGCCACCATGCCTGGCCAGTCTGTGTGTACTCTTATACAACTGGCAGTGCAGTAGGTTTGTTTACACCAGCATCACCACAAATGTGTGATTAACTCATTGCCATAAGACATTTTGATGGCTACATCACTAGGCAATAGGAATTTGTTAGTTTCATTATAATCCTGTGGGACCGCTGTCATATTTGGTCCCTTATTGACCAAAATGTCTTTATGGGACACATGACTGTAATAACAAATCACTCACAGGTACATATTAGTACTTAGAATGCCATAGGCACTGTTATTGTGGATCAAGCTCTCAGATACTATAATCACACCCATTTACAGATGGGGAAACTGAGGCACTGGGAAGGTAAATAACTTGCCAAGGTAACATAGCAAGGAAATAATGGAGTTAGGATGTGAACATTAGGCAGTGTTTCAGAGCGCATGCTTTTAACAAGCGTACTATTCTGCATGTGCCACAGGCAAAAGCATCTTAGATTTCTTTTTAGGTTTGTAGTTTCTAATACAGTGCTAAGTAAATCAACTCCCAATAAATGCTTACTATTTAATCAGGTTAGATTTAGTTATTCCATTGCCAAAGGGTGTTTATTTAATTGAAAACAAGATGGGCTGGATGAGGGTGTGCTGGCTGAACCATGTGATAACAGAGGCAGTGAGGTGTTGACTGAAACCACCTGGTTTCAAATCTCTGCGTGTCACTTTGCCAGTACCAGGATAAATCCCGTGGCCTTTATGGGAGAACTTTCATTCATTTATCAAATTTTTGTTGAGTGGCTACAATGTGCTAGCCACTGTTCTAAGTTCCAAGGACTCAATAGTAAACCAAACAGACAAAACCCTACCCTTGTGTATCTTACATCTTGCTCACATGACAATACACGTAACATGCTTAGCACAGTGCTTATGGTACTGGTTAATATTATTTATTTTTTTGAGAGGAAGTCTTGCTCTGTCACCAGGCTGGAGTGTAGTGGCGCGATCTAGGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGCTATTCTCGTGCCTCAGCCTCCCAAGTAGATGGGATTACAGGCGTGCACCACCACACCCAGTTAATTTTTGCACTTTTAGTAGAGACAGAGTTTTACCATGTTGGCCAGGAAGTCTCAGTCTCCTGACCTCATGATCTGCCTGCCTTGGCCTCCCAAAGCGCTGGGATTACAGGTGTGAGCCACGGTGCCTGACCTGTTATCATCATATGGTGCTGCTGGTTAGTGCTTTTTACAGACAGTATTGGCACATTCCTAATTTTTTGGTAGGGTGTGTCAAATGAGATAGCAAAACAGGGTTTGTAGATGGTGATGGCAAATTAGATCATAAAAGGTGATTATCGTTCTTTGAAGGTCTCCAGAATGACCACTGTTGAATTAATCATACAATAAAAATTGGCTTTAGGTTTTAAGATAGCCAGCATGTTTTCCTCAAACCTTAGAGTAGTAATTTTGATACTGTGCATTTTAGTGGTAATGGTTTAGTAGTAGCAAAGGTCTACAGACGTTTCCGTAAATGGCCATACAGTAAATGTTTTAGGATTTGCAGGCAATGTGGTCTTTCTTACAACTACTCAACTCTGCCTGCTGCTGTAAGAAGAAAGCAGCCATAGATAATATGTCAACAAATCGGTATAGCTGTGTTTCCAATAAAGTTTTATTTATATAAACAGGCATTCAGCCCACAGGTCAGTTTGCCAACCTCTGTTCCGGAAGAAAGTAAAAATTCTGTTAGCAGTAACATTGTGCAGGGGATCAGCTTTTTAAAAGAAAACATGAACTAATATTAAAAAAAATCATTGGCTCACTGCAAAGTCACAAGACTCCTTAGACACTTAAGAATCTGAATTTGACTTCTGATGGTTTAAGTTTACTATTTTGCATGACCTTATTTTCTGACTGGTTCAAGATCAGGATCGGTACTAGGGATCACTTAAGGAAGAAATTTCAAGAACCTGGAAGGGACATCTTCTCTGGAATAGAACCAGAGGAGATAAACTATCCCATGGACATTTGTATTGGGCCCTGAAGGAATTTTCAGCAGTGAGGGCTTTGCAGAATTGAAATAGAAGGGTTATCGCTGAACAGGATTTTCTTTCTCTAGACATTTTAAAATCCGGAGAAGTCCTACTCTGGCAACTGGTCAATACAGAGTTATTAATTACTCACTGATTAAAATTTTCTACTTTTTCTGTATCTTGTCCAATATGGCTTGTTTTTGATCTGGTCAGAAGGTTACTGGTGGATGGAGTGAATGGATAGTGTATTCTCTCTGGGATTCGGTGTCCAGGTTTAAGCCAGAGTGAAGTCTTGTTAAATTGCAATAAGGGAGAGGAAACCATCTGAAAGAGAGAAAAAGAAGCATTTTCTAATGTCTTTCAAGAAATGAAATTTTATTCAAGGGCCAAAAGAGCCACAGGGTAATGAGACCATGACCAGCAAACACCTATACTAGATAAAAGTAAATTTTAATTAACATATCAATAGTTTGTAGATCTTAGGTGCTTCCAGAGTGCTTGAGGTTGTTTGACAACTTTTTCTTCCCTTAAGCTCTTTTGCTTTCTCTTTGAAGATCTATTTTAAACAAAGAGAACCCCTGTTCCAATCTATTTTGATCTCAAGGATGTCTGATTTAATGTAATTTTCTCACGTTCCTACCAACTTGCCCAAGGTGAGGAATAATTTACTTTGTTAGAGCAAAAGAACAAAGAACTTTTTGGGAAATGGAGAATAGTGGACTTCCTTTAAAAATAAAAAAAGTACTGCAGTTTCGTACATCCTGGCAAAACTGCCACCTATCATTTTTAAACTTTTGCATTCTTAGATGGTCTTACTTGGATTTAAGACCTTTGTGAGTTTGTTCAAATAGGCAGTCATGCAAAAAGAGCCTGCGTTTTCTAATGGTGGTCTCCTGTGTGTTTAGCTTTGGTTGATGGGCGTATTAGAAACAAGCAGAGCACGGGTGATTCCAGCTCATTGGATACAGCAAGTAATTACCTCCCTGCTTTTGGAAACAGTTAAATATACTCCCACTCCAGCAATGAATGTAGCCAGGGCCAAGGTGGGCAGATGCTGGCTGCTCAGTGACCATGTTCAGGATGATGTGTGTAGGAGGAGAGGAAGGATTCCAAGAAGACTCAGTACCTTCTTCTAGGATTATAAGGATTTAAATAGGCCTGAGGGAAGGACCCAGCACATAGCACGTGTTCCATAAAGGGCACTTTCCATCCTTATCCCCTCTTTCTACTTTGAACTGCTCGTAGGAAGACCTACTTTAATTCAAATAAAAATGCATTTGTGTTAAACCTGCGGCAGAAGATTCAAGGGCCCTTGGCCTCCCAGGGTTTATAAATAGATGGAAAGATGTATATACTGAGAAAAAAAGTGAAATGAGAGTTATGCAAGTAGAGATGACTGTATTTGACAGCACAGGCCATGCAAATGTGAGGTGAGTGGTAAAATCAGTGTGAAAAATAGACAATGTTTGAGAAGTATAGATGGGAGGAGGGGGAGCTGGTCCAGAATGGTTAAGGAAGGCTTCATGGGGGTTGTGTGATTTGACCAAGGCCTTCATGGGTGAGTAGGATTTGGATGGATGGAACAAAGGGGATCACAGGTGGAGAGAGTTACAAGCTCCTAAAAAGCTGGTTGTGTTTTAGTTTTTTAGTTCATTGTCCTGTGTTTGGTAAATACTTAACGGATGGTTATTAAATGAATGAGTAATTATTTTGATTGCTTTTTCTCCTCTGAACTTAGTCTATAGCACACAATTAAAACTCAATTCTGTATGGTCTCACCTCATCAAGGCAATTCTTTCCTGTCTGGCTATACTATTAATACCTTGTGGGAAAGGCCCATGTGTAATATTTTTCATCCTCTCTAGTAATAACTAGAATGTTGAACATGTAGCAGATGCTGCCTAAACTCTTTCTCATTGAACAAGATGGTCAAAGACACAGGATGCTAAACTTTGATGAGAACTAGTGTTTCTTTAGGGCCCTTTAAGAAACAAATCATTGTGACCATAGATTGCTTTGCTACCAGGAAGAGCAGACCTACCTCCAGGGTCTGCCTGACACCAGTGGGAATGAACCCATATACCACTTTTGAGAATCTCCTTGCCAGCTTATGAAGATAAACCTGTGTTTTCCTGGCAACTAATTTTGTAGATGAACTTGGTCCATGCTGCTTCTCCATTATGTCAACTTTTCACCATATAGGTTTTTGATGGTCTCACCTGAAGAATGGAAGTGGAGCTAATAATTACCTAGTATCTACCATGTGCTTTAACTTCCGCAGTAGCCTTGTAGATATCACTTTTGTTCTTTTAAAAGAGAGAAGCTCAGAGCATGTAAGTGGCTTGGTCAAGGTCACATAATATGTCATGATAGATGAATTTGAACCTAGGACTCTGAGCTAGAGCTGCATTCCTTACATTGTGTTATGGTGTCCACATGCCCCTGCATTTTCATGCATTACTAGATTTGAATAATCAGAGGGGAGATAAAAGAAGCTATTTTAGATGAGGGGCAATCGTTGAGGCACAGTCAACCAATGACCTTGGCAGAAGAGGAGAGTACCTTTGAGGGGATTAATAATAAATAATCTTGAATTCCTATGATTGGGTGAGATTCCATTACAGATGGTTTTGGAAGACTTCAGACTTTATGAAATATCATGGGAACCACTGGAAAATGTTTAACTAGAGGTATGACATGATAAAATTATTAATTAATCTAATAATTAAACACACTTAGTGAGTATATATCATGTTCCGTGTTGGAACAAATCACACATTCTTCCTGCTCTCATGAAACTTTTATTCTAGTGGGCAAACAGACCTTAGATAAATAATTTCATAAATACTATATATAATACCCAAGTATGGAACATGCTTCATTATAAATGTAAAAGGTCTGTGAGAGTATAAATTTTAGACCATCCCTCTCCTGAGAAAGTTACTTTTGAGTTGAGATCCCAAGAGATGAGTAAGGGTTAACTAGCTGTATTAGTCCACTTTCATGCTGCTGACAAAGACATACCCAAGACTGGGTAATTTATAAAGAAAAAGAGGTTTAATGGACTCAGAGTTCCACGTGGCTGGGCGGTGGGGGGGGCGCCTCATGATCATGGCAGAAAACGAAAGGCACATCTTACATGGCAGCAGACAAGAGAGAGTGAGGACCAAGTGAAAGGGATTTCCCCTTATAAAACCATCAGATGGTTCAGTATGGGGGAAACTGCCTCCATGATTCAATTACCTCCCAATGGGTCCCTCCCACAGTATGTGGGAATTATGGGAGCTATAATTCAAGATGAGATTTGGGTGGGACACAGCCAAACCATATCACTAGGTAAGAAGAGGGCTCCATGCTAAGGAACAGGATATGCAAAGACCCTGTGGCAGGAGGAACTCTACCTGCTTTTTTGAAGAATTCCATAAGGTAGCCTTCAGTGGAGCTGAGTAGAGAGTGGGGGAGAGTGGGCTAAAACATGAGGGGAGAAGTAGGCAAAAGCTAAATCTCATCAGGACCTTATAGACAATTGACAGATGTTTGTCTTTATCCAGTAAGGTGTTTGTATGCTCCTTAAGTGGCAGCGGGGAGTGAGCAGAGCAGTGAAGATAAACATGAAAGCTGGTGGTAACAAATTCTGATACCTCCTCTATTCCAAAAGGAAAGGCAGAACTCAGAGGCACCATCCTCCTGTTGTGTTTGCAAGCTGTTGACACAACCTGGAAAGGTTAAAAGTTTTCAACAGACTTGTCAGAGTTTGTGTTCAATGGAAACTGACAGAGCCTACCGGCTGAGGGGCTAATTTTAATAGAAATAACCTAGGTGCGTTTGTTAATTTTCTCCGTTCCCTCAATGACCTGTCTGCATAGCGTGAAGGTGCTTTGATGTGACCAGGAGAACAGAAGGATATTTTGTGCATAGCTGACCGTGAGAGGAATGCTGGTTTTGCAATGAGGAAGCACAGGAAGATGACAGGTGAGTTGGGTGGAAGGGGAGATGAGAACATGCATCATGTGGCTTTTCCCACCTCCCCAAATGCAGCCTTGTTTATCTAAGATTCATCTTTCTTCTCTCAGAGAATTAACTTTTGTGAGTTTAGCGTGTCCATAGTTGCCAAGGAAATTAAACAAATTGGCCAAGTGTGAACATCAGGGGAGGGGAAGAAGCCCCTGCTACTTCCCTCTGATTCAGTGAGTTTGTTGCTGGTTCTCTTTGGTTTCATAAACCTTGTGGTGCTTGCCGAGGTCTTTTTAGGTCCAAGTGGCAGGGCACATTCTGCCTGTGTAAATGGACGGGGTGGGGGATGGCCTCTTTCCTACATGCAAATGATCCTGGTGTTGCCCACACATAAAGGTCTTTATCTGCTGGCTGCCATATCTGGATCTGTTCTGGGGGTGAGTTGCCAGGACAGTGTGAATGCCCTGAGAATTAGAATGGAGCCCCAAACGTGTGCACACTCTGACTTTGAGTCGTTGAGGTCTCCTAGCAGTGGCAGGCAGAGCCTCCTTAGTGGTAATGGAGCCAGACACTCTGTGGGCACCAGGGACAAGGTCATGGTGTGTGTGTTGGTGGTGGGCTGCAAAGTCAGCTCCATGTGGGGAGGGTTCTGCTGCAGGGGGCACCCCACCCTCCCTGTGAGTTCTTGGAGAAAGTTCTTAACCCCATGGATTATTTCTGGAAAGTGGAAGTCATTACACTGAGTTTACCGGAATCAAAGGAGTAGTAGGAGCAATGAGGTCCTGGATAACCCTAAATTTATCCAGTTAACTCTTAATTGTCTGGGGACTGGTTACCCATGCAGTCATGGTGAAGGCTCCCTCCTGCCTGCCCCAAAGCAGCCTGCTGATGCTCACAGCCCATCCTCCACTGCCAAGTTCCTCAGCCCCGCCCAGGAGAGGAGGGCAGCCCACATCTCACCATGCCTTCTCCATGGTTGCTTACAACATTGCTTTCTCTCATACTCCAGAGCACACTGCGCTTGAGTTACCCACCTAAAATAAGTGAAAGGAGTTAGGGAATACGGGAGATAGGAACGTGTCTGAATAAAGACATTTATTAAACAGATATCTCCCTGCCAAGCATATAGTAGGCACTCAATAATTTTTGTCTATCTTTAACCTCACTGGGCATTCAAAATTAAGAGACATTCATATTCAAAATACAGAATGATTCTTAAACAAAGTACTGGAGTTTCTTGCTGGGGCTTGGAAAAGCCTCTGTTGGTCCTCTTTAAAAAAGCATCCAGTCTATTAACTGGGAGGAATCTGAATGTGTAACACGCTGTCATGTAGGGAAAAGAAGGGTCAAGCAAGAAAAGCTAGATTAGAATGTTGTATGTTAAAGAAAGAAAAACTAGGTGCATGCTTCAGTGTAGGAGGCATCCCTGGAAAAGAGCAGGTTGAGTGATTGTGAGGATTAAGCGCACCAGCCCGGGGATCCATGAGCAGAACCAGGAAGTTGTGGGTACACAGAAGAGGAATTTGGATCAGTTCTCCAGCAAGAAAACAAAAATGTGCTTTTGACAGTAGGGGCCATATCAAAAGGAAATTGGATATCAAAGGATGTTTTAAGAAGAGCTTTGGATGTCAGGGGCCTGGAGCAGAGGGAATACAGAGCAAAAACGAAAGGCTTGGGAGGCCAGAGGTCCTCAGCTGTGGCTCTGACAGTTGGGGCAGCCAAGGCCAGAACTCACAATGGGAAGCAGGGCTTTTCTTTTGTTCTTTTAAGGGAGGGATGTTTATAGGCCACTCAAGGAAGAGACAGAGACATTAGATTTCACTGCCTGTGTGACGTTTTGTAGTCCACTCATTGGCACCCCTGAGCTTGTCAAGTCAGTCGGGTTGAGGGGGGGCTTCTCATATGGAGACCCCAAGAGTGGGTGTCTGCACCCTGCTGACAACTGCTGACAAGGAGGAAAGCACAGATTCTCTCAAGCATCCACTTTCCTCAGTGGGGCAATGACACGGGCCGGGGTGCAGAACCTTGTGCTGAGGGCTGGGAGAAATGTATGTGTAGCTTGTGCCAGAACTAGGATCCGGGGGATGACCTGGGGTTTGTTAGGGTGTGTTCTTAACCAAAGCCCCGCCTTCCCTGTGTGCCTTGGGAGATGGTTTGGGAGCTGGGCAGGCTAGGTATTCCAGGTTAGCTCCGAGCACACACAAACCCAGGCACACATTGCACCTCTGTCTCATATGGATTCTATCACCAAGACCCTGAGAATTACTTCCAGCATTCATAGCAAACCTGTCTGCTGTCCCCACCCGGTCCAGGTCCTGACCCTGACTCCCAGTGGCCCTCTGTACCATCTCCCACTTTTGCCCTCTGCTGTCCACCTCCTTTTCCTCCACCACACACAGCAGGGAGAATGTCCTTTCGGAAATGCACATCTGGTTCTGTCACTCTCCTGCTTGAAAGGCTTTCTTTTCCCCTGAGGACAAAATTAAAAGCCCTTTACCAGGTTTACAAGGCCTTGTGTGACGTTATTTTCTTATTTTAAAGGAAGGATACTCAGAGAAAAGAAGGGGAGATTCGATTTTAGAGAGATTCAATTTCTAGGATCATTCCAGTTTACCCTTCCTGCTGCTGAATTCTAGCCATACTGATCTATCAGTTTCGTGAATGTATCATGCTCTTCCCTACCTCGGGGCCCTTGCACATCTTGTTCCCAGTGCCTCGAAATTTTTATCTTATTCTCTCCACAGCTGACCCCTACTGATCCTTCCAGTCTCAAAATAAACAAGCCTTTTTTTCAGTCTCTCATGACCCTACTTTGCTTCCATTTACTTTGTTACAATTTCCAACTGGATATTCATTTATGTGATTACTTGTTCATTGTCTGTCTTCTCTATTAACCGTCCCTACCCTAAGAGGAGGGGCCATGTCTGTTTTGTTCATCTGGATGTCTTCCGTATATTTTAAATGTTGGTTGACTAGAACAGTGAATGAATGAGTGATTTGTAACAGGTTGCTGTGACTCTGTACTTTCATGGAGAAGAATTTCAGCAGCTAGTCACTGTTAACTTAATTTGTTCTCTCTACAAGCATCTGATGAGCAGTTAATATGTGCAAGCTAAGGCACATTATCTATCTTCAAGGAGATTCTGGTGAAAGAGACAGTCATAAACTATCAATCCACACAGTAGAATAAGTGTTACAACAGAGTTATATACAGGGTGGTCTGAGTACATAGTTTCTCATGCTGGTGTTCCAGGTAGTATAATTTTCTGAAATTAAAGCTGGTAAGAATCAACATACCGGGGATGTGATTAACCATTCCCAAATCTCAGAAAGACATTAGCCTAAACTGTAAGGAGTGTAAGATAAGCCGTGCTCTAGTTAATTGTAACTGAGGGCATGTGCTGGTGATAGATAATGTGATGGCTGATAAAGAATACTGAAAACCAGAGCCACGGGAATGTGTCATGGCCCCTTTCCATTAGGGGGAGTGCAGCCCCATGCCAAATGAATGGTCCCAGCTCTCTAGCCACAGGTGGCTCTGAAGATTTCTAGCCACAGACACCCCTGGACAACACAGTGAGACCTCTCTAGCCACAGATAGCCCTGGAGCCCTGAAGTGGAGAAGGGCACACTGTTCTGCTTCTTCCATGTACAGCCTGTTCTTCCAGCTTTGCAAAATGCTCTGATAAATTAGGAGAACACTTTAAAAATTGACCGCTCAGGCCGGGCACCGCTGGTCATGCCTGTAATCCTCGTACTTTGGGAGGCCAAAGAGGGTAGATCATCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGCAAAACCCCATCTCTACTAAAAATACAAAAAATTAGCTGGACCTGGTGACACGTGCCTGTAATCCCAGCTACCCAGGAGGCTGAGGCAGGAGAATCGCTGGAACCCGGAGGCGGAGGCTGCAGTGAGCCGAGATCGTGTCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCATCTCAAAAGAAAAAAAAAAAAAAAAAAAAGAAAATTGACCATTCATTCCCAGATGTTGGTGGGGAGAGGAAAGGAGACAATTTCTGGCTCTTTTGAATTCTATTCCTATAATTTAAGATGATTGACTACTTTATTAGATTTAGTATCAGACTTGTTTCCTTCTTTTTAAATTAAGTTTGACAAAAGGTAATAGCAGTGAACCCAAGTTTACTATTTTAGAACTGTCTTCACTAACTAGAAAGATGACCTTTAGATAGTTACTCCAGGAGTGTCCTACAAACGAATTTCATTCACCTAAGGGTAGAAGGATTTGAACTTTGTTTCCTGACTTGATGAGTATTTCATGATAAACCAGTTCTGGCCCATTAACTTCATTTCTCAAAACACAGGTTTAAAAAGAGCGTTTCCTCAAGGAGTTGCCATTAAAAATGGAATGAATCCAACTTGCTGGAAATAAAAATGGCCAGAGCTGAACATGGTACACAATTGTGATGAAAAGAGCTTGTTTTTTCGGTAGGAGGTATGCGTTGCGTGTGTTGGTTTTGAAGTAATAAGTAACGTTTTATAGATAACCACCAACCTGTGTCTGGTCAGCAGTCTAATGTCCCACTACTGTCAAGGATGCCTGTGATGTGTGAGCTTACCTTTCCATTCTCCTTGTATCTTTCCTGATTTATCTAGAAAATTAAATAAATAGGGAGGTAATGTTCCAAGGAAAGGTTTCCCTTCCCTCACTGGGGATTTAGTGGGGGACAGTATAGACTGTCCTTTAGGAGATAATTAGAACTGACATCTACAGAACCATCTAAACCTTGCCCAAACTTTGCACTGGGAGGTTGTGAACCGGAACCTCATTACTGAATTCCATATTGTGGAGTGTGGTCTCATCCAAGGAATGTCTGCAATTCCCATTCCAATCTGAGTAAACAGTCAGTTATGAACAGTCACTGGGGTAAACCGTAATTAGATATGTTCTTGAGGTTTTTAGAGTGATTCTTTCATACCTTTGTAAAATTGACAATACGTGAAAGATAAAAATTTCCCCACAGATATTTCAGCTAATTACTCCTTCTAGGTAAAGATTGGCCCCATTTCTTGGTCTGTCTGATGATGACTTTTCATTTTCTGCCGTAAACGAACCTAATTTGCAAATGAAAAATTTCACTGAAGCGTACGTTGCCTGCAAGGGAATTACAGCCCGGAACCTTTGGAAGTATTCAGTAGAACACGCAAGAGAATTTTAAACAAAAGACTTATGCTCTTAATTCACACAGTTAAAATAACGATTGCTCCTAAGCAGTACTTATTATTTTTAAGTTTAGACATTCCAATAACAGTAATCAAGAGGAGTTAAGTTCACTTTAAAGCAAAGCAAAGGAGGAGTAACTGTCAAAACTTGCTTAATATTTCCTGTTTGTAGGGTGAGATTTTCCTCAGATCACACCACATTCCCTTGTCGATACATGGAAGCCCTTTACAGCTTGATGTTAAGAATAGGAGTAGCAGGCTGGGTGTGCACACCTTTAACCCTAGCATTTGAGGAGGCCAAGTCGGAAGGACTGCTTGAACCCAGGAGCTCGAGACTAGCCTGGGCAACATAGTGAGACTCCTGTCTCTACAAAAAATACAAAATATTAGCTGGGCATGATGGCATGTGCCTGTAGGCTTAGTTACTCAGGAGGCAGGAGTGGGAGGTCACTTGAGCTCAGGATTTTGAGGCTGTAGTGAGCTGTGATCACGCCACTGCACTCCAGCCTGGGTGACAAAGCCAGACCTTGTTTCTTAAAAAAGTAGAAAAGAAGGAATGAAGAAAGGAAGGAGGGAGACAGAGAGGGAGGGAGACAGTGAGGGAGGCAGGGAAGGAGGGAAGAAGGGAGGGAGAAAAAAAGGGGGGAGGGAGAAAAGGGAGAGAGGGAAGGAAGGAGGGAGGGAAGAAGGAAGGAAGGAGACAGGGAGGGAGGCAGGGAAGGGGGAAAGGAAGGAAGGGAGGGAGGGAAAGAAGGAGGGAGGGAGGGAGAGAAGGAAGGAGGGAGGGAGGGAAGGAGGAAGGAGGGGGAGAAGGAGGGAAGGAAGGAAGGATTAAGGAAGGAAGGAAGGAAGGAAAGATGGAAGGAAAGATGGAGAGATAGGAATAGCAGTTCCCTTCTAGGCCCAACATACCAGGCAGAAAACTTGGGTTCCAGTCTTAGTTCCTGCAGTTATTGACTCTGACTACTGAGAAGATTCTTTGCCTTGAGTATCAGTTTTCTCAACTGTGAAGTTGGAATTAAAAGGCCAAGCATTCTTGTGCAGACTGAAATGATCCTGTATTCAAAAGCTGCAATGGTACATTGGGAATGAAGAGTAATGGTGTATCAGACTTAATTAACACTAGTTAGTCCTTGTGGTTTAGGGCAGGTGAAGTCACGATTTACAGCCCAGATAGATGTATTTTAAAAATTAAAAACAGCCAGAGAAATTATCCAAGAAGAAATTCTACATTTGTCACCTCCTTTGTACTGTACTTGAGAACTTTATTTTATCCACTTATTTATTCCAAAGATACTAATTGAACTCCTACTCTGTGCCAGGTACTGAGGATAAAATTGTAAGTAACACAAAAGTCCCTGCTCTGATGGAGTTTACCTTCCAGGCAGAGGGAAGATGACAAGCAGAAAGTCCTGGAGCCCCCTTGGAGAACAGGGTGGCTACTGTGAAGGGAGGGAGGAGAGGGATGACAGAACTGAGGTCAGAGAAAGAGGCAAGGCCAGAAAATGTGGGACCTTGGTAAATCCTGGGGAAAGTTTGCAGCAAATTCCAGGTATGTAGCAATTCCTTTTATTTATTTTGCATGCAGAAAGCCTATTACAATTTAGATATTTAACCAGCCCAATGTGCTGGAAAGCAGACCAGTCAAGACAGGCTCCTCCCTCCTTTCACTCCTGTTTATTTGCGAGTCAGTCTTTCCCGACTTTCTGGACCCTGCTCAAATCCTGCTTCCTCCACAAGCTCTTCCACAGTCTGCCCCATCGGAAACACTCCCCCTCTTGTTTGCTTTTTCCTCTTTGTAGTACTTCTCACATTCTGCCTTGTTTTAAAATTCTTCATGTTGTTCACCCTTAGTAGAGTAAGAGCCTCTGGATGCCAAGACCTTGTGTTACTCACTATTTTTTATTTTTTGTATCCATTGCCATGCACATGTGCCTTCTACATGGGCGATGCCCAGTAAATATTTATCGATTTGAAATAACTCAAATCTGTATATCAGGCTAGCAGAGAAGTGTTTCCCAAAGCGCTGCACCAGAGAGAAGCTGATCTGAGGGCACGATGGGAAATGTATCACGAACACTCACAAAATGGCTCCCCAGTGTGTATTTATCCAGATGTCCTTTTGGGATGGGACAGGACCGGTTTTTAATGACTCTGAGCTGCCTTCCCTAGGCACTAGGAGCCTACATTTTGCTGACTGTGGAAGCTCTTTGTGTGAGCTCCACGGGCAGCTGTGTGCAAGGAAGATCCAGCTCTTGTCTCATCCCTGGAAGCTTGGACAAGTCAGTTTCCCCATCTCTGAAATGGGGATTATAACCTCTCTCATGGGGACTTGGTTGTAACAGATAATCTTGTGGACTATTTTGTTAAGAAAAATAAAGATTTATGGTATTAAAATATGTATGCATGTCTAAAATAGCTTCCAGTGCTATCTGGCTGTCTTTGCCTGAATTTTACTATGTCTGTAAGTGAGATTCAGCATTTTCTTTTGGACTGTGAATTGTCGCTACTAAATGAGCTTATCAGTCTCTGGGAAGGAACAAAATGTCATTGGATTTGCCCCATGCTGCACTGCTTGTGAACTTATACCAGAGCACACTGGATAAAGCATGTACCCGATTCCGAGAAGGCTGCAGCTCTATAAGGGACAGTAGTGTACACAGCCATTCCCCAAAGCCACCTAGAAGAAACTTCAGGAGCCTTCACACCTGGCTCTGCCTCACACTCCCCCAATGTGGGTGTGGGCCTGGTAAGGTGCTGTCCGCATGGGGTCTTGCCTTCCTCATCTGCAAAGCCTCAGCTCTGGGATTCACCAAGAAGAGCCAATCTCCTGCTCCTCTCACTTCTTCCACTTGCAGACAAGCTTTTGGACTCTGCCCTTTGGCTTGTGATTCATAATTCCAAACCCCCTATCAATGATCAAATAAGCAGCAGGAAGTAGCAGTCCAGATCCTTCAGGGGCCATCTCATCATTCTGAGGACCAGGCCTTTAGTAGAAAAGATGGGCCAGTTTGGAAGTTGTCCTGACTTTTAGAAAGTAGTTTGTGTCCCAAGGGGCCCCTGGGTGTTTGTTCAGGGCCTGTATGGGCTGCCTCAAAAGGCCAGGAGGTGATGGAAAATCATGGACCTTGGGGTCCTCCAGTCCCCAGCACTCCACCTCGAACAAGCATCCTTATTTGTAATCTGATTTGCCTATAGGATTCTGCATAAGATTTTGCTTAAGCAAAGGGTTCTGCTGCTTTTTAAAAAGTGCTCAAAACCTCTAGTTTATATACTTTTAGATTTTGTGTCCTTGCACAACCTCATTCTCCATAAGATTGGAGAAAGCATTTGTCACCAGGGCCCAGCCCGCAGACTGAGTTGATATTTACAAAGTAGCCAAGATTCCTCAGATGGGTAGGCATTAACCTTGTTTAGTTGAATGCAGTCTTTTCTTTATTGGTTTTGTATGTAACTTCCTTTACAATTATTAGTACATATTATTAAAAGCTCTTTCTTTCCAGGAAATAAGCCTTTTAAAAGGCATTGTCTTTTTTAAAAGATAGGTATTTTAAAAAATATATTTTTGGTAAATAAATTCCTACTGTAAGTATCTAAAATACTTCTAAAAACTACCCCCTATGATCATCTCGGCATATACCCTTCAGAGCATTGCAGCAGCCGCCCACCTGAGCATTCTAGCTTATCCCTGGGCAAGCCAGCTCAGCCTCCAGAACACCAAAAAAATCTTTCAAAACCAAGGACTGACCAGGGCCTTCCCTGATTACAGCTTTACACCTTTACACCCAAAGGACATTCTGTTCATCCATGCCCTGAATTCTCTGATTCATCCAGTAACCTTTATTGAGTCCCCATGATATTCCAGGCACTGTCCTGAACACTGAAGAAACCAGGTTGATGCAGAAAGACTATGGGCTCTCAAGAAGATGCAGTGCTTTTTTCCTGGAATCCTCTTCCCCTTTTCTCTGCCTGGTGAAACCCGCTCCAGTAGCATCTTTTCTGAATTCTTCCTCAGGCAGAGGAACGCCTCTTTCTCATTGCTGAGGCATATGCCCATGTATCTGTTGTTCTTCTACCTAAGGTTTGCTGCAAGTAGTTGTCTGCTGGGTGCACCAAGCCCCTGAAGGGCAGTAACTGGGTCTTCTTTGTGATTGTATCTCCAGCATCTGGCTCAGCCCTGGATACCCAGTAGTGGCTCAAATAATGTTTTCTATTTCCTTCCTGATCTTTCCTATCTGTGCTGGAAATAACTAATTCCTTCTCAATTTTGTCTTCCCCACAGAACAATGAGCATAAGACATGCTGGGTGCATTTTTTGGACCTTACCACATCTTGTTTGAGAGAAGTGGGACCAATGCTGATGAAACTCTTTCCCATGGTGTGTTCTATATTCATTGGATGGGCATCGCCTACGGCTGGAGCAGGGCTGAGCTCTGTACTGGTGTCTCTTAAAACACACCAGACAGCAACAGCTGAGATACCTACTACCTGGATCTGCTTGATTAGATCATACGGTCATATTTGATTACTTAGAATGG bladder cancer 29558461 Molecular and Bioinformatics Analyses Identify 7 Circular RNAs Involved in Regulation of Oncogenic Transformation and Cell Proliferation in Human Bladder Cancer. Cai D, Liu Z, Kong G. Med Sci Monit. 2018 up microarray, qRT-PCR bladder carcinoma (high-grade and low-grade) with resection specimens containing adjacent normal bladder tissue hsa_circ_0002496 circRNA homo sapiens APPBP2 hsa_circ_0002496 GCTTGTGTAGTAAAACGTGAATTTAAGAAGGCAGAACAGTTAATTAAACATGCAGTGTATTTGGCACGGGATCATTTTGGATCCAAACACCCAAAATATTCTGATACACTGCTAGATTATGGGTTCTACTTACTCAATGTAGATAATATCTGTCAGTCTGTTGCAATTTATCAGGCAGCCCTTGACATTAGACAGTCAGTGTTTGGTGGCAAAAATATCCACGTAGCAACAGCTCATGAAGATTTGGCCTACTCTTCTTATGTCCACCAGTATAGCTCTGGGAAATTTGACAATGCACT hepatocellular carcinoma 29144509 Circular RNA expression is suppressed by androgen receptor (AR)-regulated adenosine deaminase that acts on RNA (ADAR1) in human hepatocellular carcinoma. Shi L, Yan P, Liang Y, Sun Y, Shen J, Zhou S, Lin H, Liang X, Cai X. Cell Death Dis. 2017 upregulated more than fivefold as revealed by circRNA microarray after AR knocking down in MHCC-105h cells microarray, qRT-PCR MHCC-97h, LM3 and LO11 cells hsa_circ_0002577 circRNA homo sapiens WDR26 hsa_circ_0002577 GTATCTGATGTGTAGCCATGCAGAAGACCTACGTGCAAAAGCAGAATGGGAAGGCAAAGGGACAGCTTCCCGATCTAAACTATTGGATAAACTTCAGACCTATTTACCACCATCAGTGATGCTTCCCCCACGGCGTTTACAGACTCTCCTGCGGCAGGCGGTGGAACTACAAAGGGATCGGTGCCTATATCACAATACCAAACTTGATAATAATCTAGATTCTGTGTCTCTGCTTATAGACCATGTTTGTAGTAGGAGGCAGTTCCCATGTTATACGCAGCAGATACTTACGGAGCATTGTAATGAAGTGTGGTTCTGTAAATTCTCTAATGATGGCACTAAACTAGCAACAGGATCAAAAGATACAACAGTTATCATATGGCAAGTTGATCCG endometrial cancer 29334253 Circular RNA expression in extracellular vesicles isolated from serum of patients with endometrial cancer. Xu H, Gong Z, Shen Y, Fang Y, Zhong S. Epigenomics. 2018 up RNA-seq, northern blots, qRT-PCR extracellular vesicles isolated from serum of patients with endometrial cancer hsa_circ_0002874 circRNA homo sapiens GLIS3 hsa_circ_0002874 GCTTATAACCCACACCATGGATAACTTATTGGACTTTGCCTGAAAGGAGTCATTAGTGACATTGGATATTTGACCGTCTTGGCCACAGGTTTTTCAGAATGAATGGAAGATCATGCAGCATGAGTCTCCACCGGACATCGGGAACCCCACAGGGGCCTAGGATGGTCAGTGGTCATCACATTCCTGCCATCCGAGCCCACTCCGGGACTCCTGGCCCCTCGCCCTGTGGCAGCACATCGAGTCCCACTATGGCAAGCCTTGCTAACAACCTCCATCTCAAGATGCCCTCAGGAGGAGGGATGGCTCCTCAGAACAACGTGGCTGAGAGCCGCATCCATCTGCCTGCCTTAAGCCCCAGGAGACAAATGCTCACCAATGGGAAGCCGCGATTCCAGGTCACCCAGGCTGGAGGCATGTCAGGGTCACATACTTTAAAGCCAAAGCAGCAGGAGTTTGGAAGCCCTTTTCCTCCAAATCCTGGGAAAG breast cancer 28803498 Screening circular RNA related to chemotherapeutic resistance in breast cancer. Gao D, Zhang X, Liu B, Meng D, Fang K, Guo Z, Li L. Epigenomics. 2017 up microarray, qRT-PCR MCF-7, ADM-resistant cell lines (MCF-7/ADM) hsa_circ_0002908 circRNA homo sapiens PTK2 hsa_circ_0002908 ATATGAATTGAGAATTCGTTATTTGCCAAAAGGATTTCTAAACCAGTTTACTGAAGATAAGCCAACTTTGAATTTCTTCTATCAACAGGTGAAGAGCGATTATATGTTAGAGATAGCTGATCAAGTGGACCAGGAAATTGCTTTGAAGTTGGGTTGTCTAGAAATACGGCGATCATACTGGGAGATGCGGGGCAATGCACTAGAAAAGAAGTCTAACTATGAAGTATTAGAAAAAGATGTTGGTTTAAAGCGATTTTTTCCTAAGAGTTTACTGGATTCTGTCAAG Active Pulmonary Tuberculosis 29248507 Potential Diagnostic Power of Blood Circular RNA Expression in Active Pulmonary Tuberculosis. Qian Z, Liu H, Li M, Shi J, Li N, Zhang Y, Zhang X, Lv J, Xie X, Bai Y, Ge Q, Ko EA, Tang H, Wang T, Wang X, Wang Z, Zhou T, Gu W. EBioMedicine. 2018 Upregulated in TB patients compared to healthy controls. RNA-seq, microarray, qRT-PCR healthy controls and TB patients hsa_circ_0003159 circRNA homo sapiens CACNA2D1 hsa_circ_0003159 CCTGAGAAAAATGACAGTGAGCCAGGCAGCCAGAGGATAAAACCTGTTTTCATTGAAGATGCTAATTTTGGACGACAAATATCTTATCAGCACGCAGCAGTCCATATTCCTACTGACATCTATGAGGGCTCAACAATTGTGTTAAATGAACTCAACTGGACAAGTGCCTTAGATGAAGTTTTCAAAAAGAATCGCGAGGAAGACCCTTCATTATTGTGGCAGGTTTTTGGCAGTGCCACTGGCCTAGCTCGATATTATCCAGCTTCACCATGGGTTGATAATAGTAGAACTCCAAATAAGATTGACCTTTATGATGTACGCAGAAGACCATGGTACATCCAAGGAGCTGCATCTCCTAAAGACATGCTTATTCTGGTGGATGTGAGTGGAAGTGTTAGTGGATTGACACTTAAACTGATCCGAACATCTGTCTCCGAAATGTTAGAAACCCTCTCAGATGATGATTTCGTGAATGTAGCTTCA gastric cancer 28618205 Reduced expression of circRNA hsa_circ_0003159 in gastric cancer and its clinical significance. Tian M, Chen R, Li T, Xiao B. J Clin Lab Anal. 2018 Expression of hsa_circ_0003159 is down-regulated in gastric carcinoma tissues qRT-PCR paired fresh gastric cancer tissues and adjacent non-tumorous tissues The area under ROC curve (AUC) was up to 0.75 (P<.001). paired fresh gastric cancer tissues and adjacent non-tumorous tissues hsa_circ_0003204 circRNA homo sapiens USP36 hsa_circ_0003204 GGCTGTGTCACCTGCTCCCCAATCATCCAGCCGCCTGCAACCCCCCTTCAGCCCCCACCCCACATTGCTGTCCAGTACCCCCAAGCCCCCAGGGACGTCAGAACCACGGAGCTGCTCCTCCATCTCGACGGCGCTGCCTCAGGTCAACGAGGACCTTGTGTCTCTTCCACACCAGTTGCCAGAGGCCAGTGAGCCCCCCCAGAGCCCCTCTGAGAAGAGGAAAAAGACCTTTGTGGGAGAGCCGCAGAGGCTGGGCTCAGAGACGCGCCTCCCACAGCACATCAGGGAGGCCACTGCGGCTCCCCACGGGAAGAGGAAGAGGAAGAAGAAGAAGCGCCCGGAGGACACAGCTGCCAGCGCCCTGCAGGAGGGGCAGACACAGAGACAGCCTGGGAGCCCCATGTACAGGAGGGAGGGCCAGGCACAGCTGCCCGCTGTCAGACGGCAGGAAGATGGCACACAGCCACAGGTGAATGGCCAGCAGGTGGGATGTGTTACGGACGGCCACCACGCGAGCAGCAGGAAGCGGAGGAGGAAAGGAGCAGAAGGTCTTGGTGAAGAAGGCGGCCTGCACCAGGACCCACTTCGGCACAGCTGCTCTCCCATGGGTGATGGTGATCCAGAGGCCATGGAAGAGTCTCCAAGGAAAAAGAAAAAGAAAAAAAGAAAGCAGGAGACACAGCGGGCAGTAGAAGAGGATGGGCATCTCAAATGCCCAAGGAGTGCCAAGCCCCAAGATGCTGTTGTCCCCGAGTCCAGCAGCTGCGCACCATCCGCGAATGGCTGGTGTCCTGGGGACCGCATGG atherosclerosis 28946214 Circular RNA hsa_circ_0003575 regulates oxLDL induced vascular endothelial cells proliferation and angiogenesis. Li CY, Ma L, Yu B. Biomed Pharmacother. 2017 Significantly up-regulated in HUVECs treated with oxLDL compared to HUVECs controls. microarray, qRT-PCR Human umbilical vein endothelial cells circPTK2 circRNA homo sapiens PTK2 hsa_circ_0003221 AATATGACAGATACCTAGCATCTAGCAAAATAATGGCAGCTGCTTACCTTGACCCCAACTTGAATCACACACCAAATTCGAGTACTAAGACTCACCTGGGTACTGGTATGGAACGTTCTCCTGGTGCAATGGAGCGAGTATTAAAGGTCTTTCATTATTTTGAAAGCAATAGTGAGCCAACCACCTGGGCCAGTATTATCAGGCATGGAGATGCTACTGATGTCAGGGGCATCATTCAGAAGATAGTGGACAGTCACAAAGTAAAGCATGTGGCCTGCTATGGATTCCGCCTCAGTCACCTGCGGTCAGAGGAGGTTCACTGGCTTCACGTGGATATGGGCGTCTCCAGTGTGAGGGAGAAGTATGAGCTTGCTCACCCACCAGAGGAGTGGAAATATGAATTGAGAATTCGTTATTTGCCAAAAGGATTTCTAAACCAGTTTACTGAAGATAAGCCAACTTTGAATTTCTTCTATCAACAGGTGAAGAGCGATTATATGTTAGAGATAGCTGATCAAGTGGACCAGGAAATTGCTTTGAAGTTGGGTTGTCTAGAAATACGGCGATCATACTGGGAGATGCGGGGCAATGCACTAGAAAAGAAGTCTAACTATGAAGTATTAGA bladder cancer 29125888 Circular RNA hsa_circ_0003221 (circPTK2) promotes the proliferation and migration of bladder cancer cells. Xu ZQ, Yang MG, Liu HJ, Su CQ. J Cell Biochem. 2018 CircPTK2 is highly expressed in migrated cancer cells and in metastatic lymph nodes RNA-seq, qRT-PCR bladder carcinoma tissue, matched para-carcinoma tissue, and metastatic lymph node tissue, T24 and 5637 cells CircPTK2 overexpression promoted the proliferation and migration of bladder cancer cells. CircPTK2 knockdown inhibited the proliferation and migration of bladder cancer cells gain of function, loss of function 5637 and T24 cells circRNA GAPVD1 circRNA homo sapiens GAPVD1 hsa_circ_0003270 GTGCCCACCAGCTGACCTCTCCTCCTTCTCAGTCAGAGTCTCTGCTGGCCATGTTTGATCCACTGTCTTCACATGAAGGGGCTTCTGCTGTGGTAAGGCCAAAGGTTCACTATGCTAGGCCATCGCATCCACCACCAGATCCCCCAATCCTGGAAGGAGCTGTGGGAGGAAATGAGGCCAGGTTGCCAAACTTTGGTTCCCATGTTTTAACTCCAGCTGAAATGGAGGCATTCAAGCAAAGGCATTCTTACCCTGAGAGACTAGTTCGAAGCAGGAGCTCTGATATAGTATCTTCTGTCCGGAGACCCATGAGTGACCCCAGCTGGAACCGGCGTCCAGGAAATGAAGAGCGAGAACTCCCTCCAGCTGCAGCCATTGGTGCTACTTCTTTGGTGGCTGCACCTCATTCATCATCTTCATCCCCGAGTAAGGACTCCTCAAGAGGAGAG 25558066 Analysis of intron sequences reveals hallmarks of circular RNA biogenesis in animals. Ivanov A, Memczak S, Wyler E, Torti F, Porath HT, Orejuela MR, Piechotta M, Levanon EY, Landthaler M, Dieterich C, Rajewsky N. Cell Rep. 2015 This circRNA with top H score and high/medium expression of the host transcript was (1) resistant to RNase R and (2) had the predicted head-to-tail junctions, as validated by Sanger sequencing, suggesting that the circRNA exists in circularized form in HEK293 cells. qRT-PCR, sanger sequencing HEK293 cells hsa_circ_0003327 circRNA homo sapiens LRWD1 hsa_circ_0003327 CCTGTCAGGATTGGAGCTGCTTTCCGAGCACCTGGACCCCAAACTCCTGTGCCGCCTGACGCAGCTGCAGGAGCTTGACCTGTCTAACAACCACCTGGAGACGCTGCCGGACAACCTGGGCCTGTCCCACCTGCGTGTCCTCCGCTGCGCCAACAACCAGCTGGGGGATGTTACTGCCTTGTGCCAGTTCCCCAAGCTCGAGGAACTCAGCCTGGAGGGCAACCCCTTCCTGACGGTCAATGACAACCTGAAAGTCTCCTTTCTCCTGCCCACGCTCCGTAAGGTCAATGGCAAGGATGCGTCCTCAACTTACTCTCAGGTGGAGAACCTGAATCGGGAGCTGACCAGCAGG male infertile diseases 27958373 Identification and characterization of human testis derived circular RNAs and their existence in seminal plasma. Dong WW, Li HM, Qing XR, Huang DH, Li HG. Sci Rep. 2016 To validate these predicted circRNAs, 55 circRNAs of different abundance and lengths were randomly chosen for subsequent RT-PCR validation. Divergent primers were designed for circRNA detection. Among the 55 circRNAs, 30 of them could be specifically amplified. qRT-PCR human testis hsa_circ_0003357 circRNA homo sapiens ADD3 hsa_circ_0003357 GGGTATAGAACAGGCTATGCTTACAGGCATCCTCTCATTCGAGAGAAGCCTAGGCACAAGAGTGATGTGGAAATCCCAGCAACTGTGACTGCTTTTTCCTTTGAAGACGATACAGTGCCACTCTCTCCTCTCAAATACATGGCACAGAGGCAACAGCGTGAAAAAACAAGATGGCTGAACTCACCAAATACTTACATGAAAGTGAATGTGCCTGAGGAGTCTCGGAACGGAGAAACCAGTCCCCGAACCAAAATCACGTGGATGAAAGCAGAAGACTCATCTAAAGTTAGTGGTGGAACACCTATCAAAATTGAAGATCCAAATCAGTTTGTTCCTTTAAACACAAACCCGAATGAGGTACTAGAAAAGAGAAATAAGATTCGGGAACAAAATCGATATGACTTGAAAACAGCAGGACCACAATCTCAGTTGCTTGCTGGAATTGTTGTGGATAAGCCACCTTCTACTATGCAATTTGAAGATGATGATCATGGCCCACCAGCTCCTCCTAACCCATTTAGTCATCTCACAGAAGGAGAACTTGAAGAGTATAAGAGGACAATCGAACGTAAACAACAAGGCCTAGAAG male infertile diseases 27958373 Identification and characterization of human testis derived circular RNAs and their existence in seminal plasma. Dong WW, Li HM, Qing XR, Huang DH, Li HG. Sci Rep. 2016 To validate these predicted circRNAs, 55 circRNAs of different abundance and lengths were randomly chosen for subsequent RT-PCR validation. Divergent primers were designed for circRNA detection. Among the 55 circRNAs, 30 of them could be specifically amplified qRT-PCR human testis hsa_circRNA_102002 circRNA homo sapiens USP22 hsa_circ_0003505 ATTCACCAGACCAGAGCACTTGGGCAGCAGCGCCAAGATCAAGTGCAGCGGTTGCCATAGCTACCAGGAGTCCACAAAGCAGCTCACTATGAAGAAACTGCCCATCGTAGCCTGTTTTCATCTCAAACGATTTGAACACTCAGCCAAGCTGCGGCGGAAGATCACCACGTATGTGTCCTTCCCCCTGGAGCTGGACATGACCCCTTTCATGGCCTCCAG papillary thyroid carcinoma 28288173 Microarray profiling of circular RNAs in human papillary thyroid carcinoma. Peng N, Shi L, Zhang Q, Hu Y, Wang N, Ye H. PLoS One. 2017 upregulated microarray, qRT-PCR PTC tumors, matching contralateral normal samples, benign thyroid lesions (i.e., follicular adenoma samples and multinodular goiter samples) hsa-miR-141-5p, hsa-miR-625-5p, hsa-miR-143-3p, hsa-miR-124-5p, hsa-miR-191-3p circRNA-miRNA predicted hsa_circ_0003570 circRNA homo sapiens FAM53B hsa_circ_0003570 CACACGCCAAAGAAGATGAGTCAAGGACCTACACTTTTCTCTTGTGGAATTATGGAAAATGACAGATGGCGAGACCTGGACAGGAAATGCCCTCTTCAGATTGACCAACCGAGCACCAGCATCTGGGAATGCCTGCCTGAAAAGGACAGCTCACTATGGCACCGGGAGGCAGTGACCGCCTGCGCTGTGACCAGTCTGATCAAAGACCTCAGCATCAGCGACCACAACGGGAACCCCTCAGCACCCCCTAGCAAGCGCCAGTGCCGCTCACTGTCCTTCTCCGATGAGATGTCCAGTTGCCGGACATCATGGAGGCCCTTGGGCTCCAAAGTCTGGACTCCCGTGGAAAAGAGACGCTGCTACAGCGGGGGCAGCGTCCAGCGCTATTCCAACGGCTTCAGCACCATGCAGAGGAGTTCCAGCTTCAGCCTCCCTTCCCGGGCCAACGTGCTCTCCTCACCCTGCGACCAGGCAGGACTCCACCACCGATTTGGAGGGCAGCCCTGCCAAGGGGTGCCAGGCTCAGCCCCGTGTGGACAGGCAGGTGACACCTGGAGCCCTGACCTGCACCCCGTGGGAGGAGGCCGGCTGGACCTGCAGCGGTCCCTCTCTTGCTCACATGAGCAGTTTTCCTTTGTGGAATACTGTCCTCCCTCAGCCAACAGCACACCTGCCTCAACACCAGAGCTGGCGAGACGCTCCAGCGGCCTTTCCCGCAGCCGCTCCCAGCCGTGTGTCCTTAACGACAAGAAGGTCGGTGTTAAAAGGCGGCGCCCTGAAGAAGTGCAAGAGCAGAGGCCTTCTCTAGACCTTGCCAAGATGGCACAG hepatocellular carcinoma 28493512 Decreased expression of hsa_circ_0003570 in hepatocellular carcinoma and its clinical significance. Fu L, Wu S, Yao T, Chen Q, Xie Y, Ying S, Chen Z, Xiao B, Hu Y. J Clin Lab Anal. 2018 hsa_circ_0003570 levels were significantly down-regulated in HCC qRT-PCR, RT-PCR and sanger sequencing LO2, HepG2, SMMC-7721, MHCC97L, MHCC97H, and HCCLM3, HCC tissues and adjacent non-tumorous tissues the area under the ROC curve (AUC) was 0.70 HCC tissues hsa_circ_0003575 circRNA homo sapiens CHMP5 hsa_circ_0003575 GTTGATGCTATGAAACTGGGAGTAAAGGAAATGAAGAAGGCATACAAGCAAGTGAAGATCGACCAGATTGAGGATTTACAAGACCAGCTAGAGGATATGATGGAAGATGCAAATGAAATCCAAGAAGCACTGAGTCGCAGTTATGGCACCCCAGAACTGGATGAAGATGATTTAGAAGCAGAGTTGGATGCACTAGGTGATGAGCTTCTGGCTGATGAAGACAGTTCTTATTTGGATGAGGCAGCATCTGCACCTGCAATTCCAGAAGGTGTTCCCACTGATACAAAAAACAAG atherosclerosis 28946214 Circular RNA hsa_circ_0003575 regulates oxLDL induced vascular endothelial cells proliferation and angiogenesis. Li CY, Ma L, Yu B. Biomed Pharmacother. 2017 Significantly up-regulated in HUVECs treated with oxLDL compared to HUVECs controls. microarray, qRT-PCR Human umbilical vein endothelial cells Loss-of-function experiments indicated that hsa_-circ_0003575 silencing promoted the proliferation and angiogenesis ability of HUVECs. loss of function Human umbilical vein endothelial cells miR-199-3p, miR-9-5p, miR-377-3p and miR-141-3p circRNA-miRNA Human umbilical vein endothelial cells predicted Bioinformatics online tools (starBase, circRase,TargetScan, miRBase) predicted that hsa_circ_0003575 had potential target miRNAs, including miR-199-3p, miR-9-5p, miR-377-3p and miR-141-3p. hsa_circ_0003707 circRNA homo sapiens CD44 hsa_circ_0003707 GTACGTCTTCAAATACCATCTCAGCAGGCTGGGAGCCAAATGAAGAAAATGAAGATGAAAGAGACAGACACCTCAGTTTTTCTGGATCAGGCATTGATGATGATGAAGATTTTATCTCCAGCACCATTTCAACCACACCACGGGCTTTTGACCACACAAAACAGAACCAGGACTGGACCCAGTGGAACCCAAGCCATTCAAATCCGGAAGTGCTACTTCAGACAACCACAAGGATGACTGATGTAGACAGAAATGGCACCACTGCTTATGAAGGAAACTGGAACCCAGAAGCACACCCTCCCCTCATTCACCATGAGCATCATGAGGAAGAAGAGACCCCACATTCTACAAGCACAATCCAGGCAACTCCTAGTAGTACAACGGAAGAAACAGCTACCCAGAAGGAACAGTGGTTTGGCAACAGATGGCATGAGGGATATCGCCAAACACCCAAAGAAGACTCCCATTCGACAACAGGGACAGCTGCAGCCTCAGCTCATACCAGCCATCCAATGCAAGGAAGGACAACACCAAGCCCAGAGGACAGTTCCTGGACTGATTTCTTCAACCCAATCTCACACCCCATGGGACGAGGTCATCAAGCAGGAAGAAGGATGGATATGGACTCCAGTCATAGTATAACGCTTCAGCCTACTGCAAATCCAAACACAGGTTTGGTGGAAGATTTGGACAGGACAGGACCTCTTTCAATGACAACGCAGCAGAGTAATTCTCAGAGCTTCTCTACATCACATGAAGGCTTGGAAGAAGATAAAGACCATCCAACAACTTCTACTCTGACATCAAGCAATAGGAATGATGTCACAGGTGGAAGAAGAGACCCAAATCATTCTGAAGGCTCAACTACTTTACTGGAAGGTTATACCTCTCATTACCCACACACGAAGGAAAGCAGGACCTTCATCCCAGTGACCTCAGCTAAGACTGGGTCCTTTGGAGTTACTGCAGTTACTGTTGGAGATTCCAACTCTAATGTCAATCGTTCCTTATCAG gastric cancer 28639908 Circular RNAs play an important role in late-stage gastric cancer: Circular RNA expression profiles and bioinformatics analyses. Fang Y, Ma M, Wang J, Liu X, Wang Y. Tumour Biol. 2017 upregulated in GC microarray, qRT-PCR III stage gastric cancer and paired paracarcinoma tissue hsa_circ_0003838 circRNA homo sapiens TTBK2 hsa_circ_0003838 CCTCGAGCTGTGGCAGGTTTTCGAGGGACAGTTCGTTATGCATCAATCAACGCACATCGGAACAGGGAAATGGGAAGACATGATGACCTTTGGTCCTTATTCTACATGTTGGTGGAGTTTGTGGTTGGTCAGCTGCCCTGGAGAAAAATAAAGGACAAGGAGCAAGTAGGCTCTATTAAGGAGAGATATGACCACAGGCTCATGTTGAAACATCTCCCTCCAGAATTCAGCATCTTTCTAGACCATATCTCTTCTTTGGATTATTTTACAAAACCAGACTACCAGCTTCTTACATCCGTGTTTGACAATAGCATCAAGACTTTTGGAGTAATTGAGAGTGACCCTTTTGACTGGGAGAAGACTGGAAATGATGGCTCCCTAACAACCACCACTACTTCTACCACCCCTCAGTTGCACACTCGCTTGACCCCTGCTGCAATTGG breast cancer 28803498 Screening circular RNA related to chemotherapeutic resistance in breast cancer. Gao D, Zhang X, Liu B, Meng D, Fang K, Guo Z, Li L. Epigenomics. 2017 down microarray, qRT-PCR MCF-7, ADM-resistant cell lines (MCF-7/ADM) circSP100 circRNA homo sapiens SP100 hsa_circ_0003922 GATGTTCACGGAAGACCAGGGTGTAGATGACAGGCTGCTCTATGACATTGTATTCAAGCACTTCAAAAGAAATAAGGTGGAGATTTCAAATGCAATAAAAAAGACATTTCCATTCCTCGAGGGCCTCCGTGATCGTGATCTCATCACAAATAAAATGTTTGAAGATTCTCAAGATTCTTGTAGAAACCTGGTCCCTGTACAGAGAGTGGTGTACAATGTTCTTAGTGAACTGGAGAAGACATTTAACCTGCCAGTTCTGGAAGCACTGTTCAGCGATGTCAACATGCAGGAATACCCCGATTTAATTCACATTTATAAAGGCTTTGAAAATGTAATCCATGACAAATTGCCTCTCCAAGAAAGTGAAGAAGAAGAGAGGGAGGAGAGGTCTGGCCTCCAACTAAGTCTTGAACAAGGAACTGGTGAAAACTCTTTTCGAAGCCTGACTTGGCCACCTTCGGGTTCCCCATCTCATGCTGGTACAACCCCACCTGAAAATGGACTCTCAGAGCACCCCTGTGAAACAGAACAGATAAATGCAAAGAGAAAAGATACAACCAGTGACAAAGATGATTCGCTAGGAAGCCAACAAACAAATGAACAATGTGCTCAAAAGGCTGAGCCAACAGAGTCCTGCGAACAAATTGCTGTCCAAGTGAATAATGGGGATGCTGGAAGGGAGATGCCCTGCCCGTTGCCCTGTGATGAAGAAA Lupus Nephritis 29499937 circHLA-C Plays an Important Role in Lupus Nephritis by Sponging miR-150. Luan J, Jiao C, Kong W, Fu J, Qu W, Chen Y, Zhu X, Zeng Y, Guo G, Qi H, Yao L, Pi J, Wang L, Zhou H. Mol Ther Nucleic Acids. 2018 Significantly upregulated in LN renal biopsies compared with NC kidneys RNA-seq, qRT-PCR lupus nephritis renal biopsies and negtive control kidneys hsa_circ_0004018 circRNA homo sapiens SMYD4 hsa_circ_0004018 ACGTGTCTTAAAGACATTAACAGAGCACAGACACATGGGTATCCAGAAAGGTTGCAACCCAAGATTATGTTACGTAAAGCAGAATGTCTGGTGGCCCTGGGGAGACTGCAGGAGGCAAGCCAGACCATCAGTGATCTTGAAAGGAACTTCACAGCCACACCAGCCCTAGCAGATGTCCTCCCTCAGACTCTGCAGAGAAACCTCCATCGTCTGAAAATGAAGATGCAAGAAAAGGACAGTCTCACAGAAAGCTTCCCAGCAGCTCTGGCCAAAACCCTTGAGGATGCAGCGCTGAGGGAGGAGAATGAACAACTTTCCAATGCCTCATCATCCATCGGCTTATGCGTAGATCCTTTAAAAGGTCGCTGTCTCGTTGCCACAAAAGATATTCTCCCAGGAGAGCTCCTGGTGCAGGAGGATGCTTTTGTGAGTGTTCTCAACCCAGGAGAACTGCCACCACCGCATCACGGCCTAGACAGCAAATGGGACACCAGAGTCACCAATGGGGACCTCTATTGTCACCGATGTTTGAAGCACACTTTGGCCACAGTTCCGTGTGACGGATGCAGTTATGCCAAGTATTGCAGCCAGGAGTGTTTGCAGCAGGCCTGGGAGCTCTACCACAGGACAGAATGTCCTCTGGGAGGGCTGCTTCTCACACTGGGTGTCTTTTGCCACATTGCCCTGAGGTTGACTCTTTTGGTGGGATTTGAGGATGTTCGCAAAATCATAACGAAGCTTTGTGATAAGATTAGTAACAAGGACATCTGTTTACCTGAAAGCAACAATCAGGTCAAGACACTTAATTATGGCCTAGGGGAGAGTGAGAAAAATGGCAACATCGTTGAGACCCCAATTCCTGGATGCGATATTAATGGGAAGTATGAAAATAATTATAATGCTGTCTTCAACCTTTTGCCCCACACTGAAAACCATAGCCCAGAGCACAAATTCCTCTGTGCTCTCTGTGTTTCTGCACTGTGCAGACAGCTAGAAGCAGCCAGTTTACAGGCCATCCCAACTGAGAGGATTGTGAACTCCTCTCAGCTTAAAGCAGCAGTGACACCTGAATTGTGTCCTGACGTGACTATTTGGGGAGTGGCGATGCTGAGACACATGTTACAGCTTCAGTGTAACGCTCAGGCGATGACCACCATACAACACACAG hepatocellular carcinoma 28938566 Screening differential circular RNA expression profiles reveals hsa_circ_0004018 is associated with hepatocellular carcinoma. Fu L, Yao T, Chen Q, Mo X, Hu Y, Guo J. Oncotarget. 2017 downregulated in HCC microarray, qRT-PCR HCC tissues and para-tumorous tissues, HepG2, Huh7, SMMC-7721, MHCC97H, HCCLM3, L02 hsa_circ_0004018 level was correlated with serum alpha-fetoprotein (AFP) level, tumor diameters, differentiation, Barcelona Clinic Liver Cancer (BCLC) stage and Tumor-node-metastasis (TNM) stage. The area under the ROC curve (AUC) was 0.848 (95% CI=0.803¨C0.894, P<0.001). HCC tissues and para-tumorous tissues hsa-miR-30e-5p, hsa-miR-647, hsa-miR-92a-1-5p, hsa-miR-660-3p and hsamiR-626 circRNA-miRNA predicted MYC hsa_circ_0004136 circRNA homo sapiens KCNQ5 hsa_circ_0004136 TTTTCTCCTTGTCTTTGGTTGCTTGATTTTGTCAGTGTTTTCTACCATCCCTGAGCACACAAAATTGGCCTCAAGTTGCCTCTTGATCCTGGAGTTCGTGATGATTGTCGTCTTTGGTTTGGAGTTCATCATTCGAATCTGGTCTGCGGGTTGCTGTTGTCGATATAGAGGATGGCAAGGAAGACTGAGGTTTGCTCGAAAGCCCTTCTGTGTTATAG Acute myeloid leukemia 28282919 Characterization of hsa_circ_0004277 as a New Biomarker for Acute Myeloid Leukemia via Circular RNA Profile and Bioinformatics Analysis. Li W, Zhong C, Jiao J, Li P, Cui B, Ji C, Ma D. Int J Mol Sci. 2017 upregulated microarray, qRT-PCR BM samples from 113 AML patients and 12 healthy controls circ-Amotl1 circRNA homo sapiens AMOTL1 hsa_circ_0004214 TTGAAGATCCTCTTTGTAACTTCCACTCCCCAAACTTCCTGAGGATCTCAGAGGTGGAAATGAGAGGTTCCGAGGATGCGGCAGCTGGAACAGTATTGCAGCGGCTGATCCAGGAACAACTGCGGTATGGCACCCCAACCGAGAACATGAACTTGCTGGCCATTCAGCACCAGGCCACAGGGAGTGCAGGACCAGCCCATCCTACAAACAACTTTTCTTCCACGGAAAACCTCACTCAAGAAGACCCACAAATGGTCTACCAGTCAGCACGCCAAGAACCGCAGGGTCAAGAACACCAGGTGGACAATACGGTGATGGAGAAACAGGTCCGGTCCACGCAGCCTCAGCAGAACAACGAGGAACTGCCCACTTACGAGGAGGCCAAAGCACAGTCGCAGTTCTTCAGGGGGCAGCAGCAGCAGCAACAGCAGCAGGGGGCGGTGGGCCATGGTTACTACATGGCAGGGGGCACCAGTCAGAAGTCCCGAACTGAGGGGAGGCCCACTGTGAACCGTGCCAACAGTGGACAGGCGCATAAGGACGAGGCGCTGAAGGAACTGAAGCAGGGCCACGTCCGCTCGCTCAGCGAGAGAATCATGCAGCTGTCCCTGGAGAGGAATGGGGCCAAGCAACACCTTCCCGGCTCGGGGAATGGAAAGGGCTTCAAAGTAGGAGGGGGGCCCTCCCCTGCCCAGCCTGCAGGTAAAGTGCTGGACCCTCGGGGTCCTCCACCTGAGTACCCCTTCAAGACCAAGCAAATGATGTCCCCAGTCAGCAAGACCCAGGAGCACGGACTTTTTTATGGTGACCAGCACCCCGGGATGCTCCACGAGATGGTCAAGCCCTACCCTGCTCCTCAGCCTGTGAGAACAGATGTGGCCGTCCTGCGGTACCAGCCACCCCCTGAGTATGGGGTAACGAG cardiovascular diseases 29109781 A Circular RNA Binds To and Activates AKT Phosphorylation and Nuclear Localization Reducing Apoptosis and Enhancing Cardiac Repair. Zeng Y, Du WW, Wu Y, Yang Z, Awan FM, Li X, Yang W, Zhang C, Yang Q, Yee A, Chen Y, Yang F, Sun H, Huang R, Yee AJ, Li RK, Wu Z, Backx PH, Yang BB. Theranostics. 2017 circ-Amotl1 was preferentially expressed in neonate cardiac tissue. neonatal cardiac tissues expressed higher levels of circ-Amotl1 relative to those from post-natal patients. qRT-PCR neonate cardiac tissue, post-natal patients circ-Amotl1 potentiates AKT-enhanced cardiomyocyte survival. In primary cardiomyocytes, epithelial cells, and endothelial cells, we found that forced circ-Amotl1 expression increased the nuclear fraction of pAKT. We further detected increased nuclear pAKT in circ-Amotl1-treated hearts. In vivo, circ-Amotl1 expression was also found to be protective against Doxorubicin (Dox)-induced cardiomyopathy. loss of function, gain of function primary cardiomyocytes, epithelial cells, endothelial cells, MCF cells, YPEN cells a mouse model of Dox-induced cardiomyopathy neonate cardiac tissue, post-natal patients AKT and PDK1 circRNA-protein MCF cells, YPEN cells RNA pull-down circ-Amotl1 physically binds to both PDK1 and AKT1, facilitating the cardio-protective nuclear translocation of pAKT. hsa_circ_0004264 circRNA homo sapiens NMD3 hsa_circ_0004264 CTTGTGCTGTGAGTGTGGTGTTCCGATAAGTCCAAATCCTGCCAATATTTGTGTGGCCTGTTTGCGAAGTAAAGTGGACATCAGCCAAGGTATTCCGAAACAAGTCTCGATTTCGTTCTGCAAACAATGTCAAAGGTATTTTCAACCACCAGGAACTTGGATACAGTGTGCTTTAGAATCCAGGGAACTTCTTGCTTTGTGCTTGAAAAAAATCAAAGCCCCTCTGAGTAAGGTACGGCTTGTAGATGCAGGCTTTGTTTGGACTGAGCCTCATTCTAAGAGACTTAAAGTTAAACTGACTATTCAGAAAGAGGTGATGAATGGTGCTATCCTTCAACAAGTGTTTGTGGTGGATTATGTTGTTCAGTCCCAAATGTGTGGAGATTGCCATAGAGTAGAAGCTAAGGATTTCTGGAAGGCTGTGATTCAAGTGAGGCAAAAGACTTTGCATAAAAAAACTTTCTACTATCTGGAACAGTTAATTCTGAAATATGGAATGCATCAGAATACACTTCGTATCAAAGAGATTCATG atherosclerosis 28946214 Circular RNA hsa_circ_0003575 regulates oxLDL induced vascular endothelial cells proliferation and angiogenesis. Li CY, Ma L, Yu B. Biomed Pharmacother. 2017 Significantly down-regulated in HUVECs treated with oxLDL compared to HUVECs controls. microarray, qRT-PCR Human umbilical vein endothelial cells hsa_circ_0004277 circRNA homo sapiens WDR37 hsa_circ_0004277 TACGTAGAGAAATCGACACTCTTAATGAACGTTTAGCTGCTGAAGGACAAGCGATTGATGGAGCAGAGCTGAGTAAGGGCCAACTCAAAACAAAAGCCAGTCACAGCACCAGCCAGCTCTCCCAGAAACTGAAGACCACTTACAAGGCTTCCACCAGCAAG Acute myeloid leukemia 28282919 Characterization of hsa_circ_0004277 as a New Biomarker for Acute Myeloid Leukemia via Circular RNA Profile and Bioinformatics Analysis. Li W, Zhong C, Jiao J, Li P, Cui B, Ji C, Ma D. Int J Mol Sci. 2017 downregulated microarray, qRT-PCR BM samples from 113 AML patients and 12 healthy controls Area under the ROC curve (AUC) was 0.957. BM samples from AML patients and healthy controls circSNTB2 circRNA homo sapiens SNTB2 hsa_circ_0004354 GTTGGTTCATTCTGGCTCCGGATGTCGATCCCCCTCCCTTGGATCTGACCTTACATTTGCTACCAGGACAGGCTCTCGACAGGGCATTGAGATGCATCTCTTCAGGGTGGAGACACATCGGGATCTGTCATCCTGGACCAGGATACTTGTTCAGGGTTGCCATGCTGCTGCTGAGCTGATCAAGGAAGTCTCTCTAG 28444238 High-purity circular RNA isolation method (RPAD) reveals vast collection of intronic circRNAs. Panda AC, De S, Grammatikakis I, Munk R, Yang X, Piao Y, Dudekula DB, Abdelmohsen K, Gorospe M. Nucleic Acids Res. 2017 circRNA junctions were indeed amplified and verifying the presence of backsplice sites in these transcripts. qRT-PCR HeLa hsa_circRNA_104566 circRNA homo sapiens PSD3 hsa_circ_0004458 CAATGCTGGGGTGAAAACAACACGGCTAGAAGCTCATTCTGAAATGGGGAGCACTGAAATTTTGGAAAAGGAGACCCCAGAAAATCTCAGTAATGGTACCAGCAGCAATGTGGAAGCAGCCAAAAGGTTGGCCAAACGCCTTTATCAGCTGGACAGATTCAAAAGATCAGATGTTGCAAAACACCTTGGCAAGAACAACGAATTTAGCAAACTAGTTGCAGAAGAATATCTGAAGTTTTTTGATTTTACAGGAATGACGCTGGATCAGTCACTCAGGTATTTCTTTAAAGCATTCTCTCTTGTGGGAGAAACTCAAGAACGAGAGAGAGTTTTAATACACTTCTCCAATAGATATTTTTATTGTAACCCAGATACCATTGCTTCACAAGATGGAGTCCATTGCCTTACCTGTGCAATAATGCTTCTTAATACCGATCTACATGGCCAC papillary thyroid carcinoma 28288173 Microarray profiling of circular RNAs in human papillary thyroid carcinoma. Peng N, Shi L, Zhang Q, Hu Y, Wang N, Ye H. PLoS One. 2017 upregulated microarray, qRT-PCR PTC tumors, matching contralateral normal samples, benign thyroid lesions (i.e., follicular adenoma samples and multinodular goiter samples) hsa-miR-450b-5p, hsa-miR-205-3p, hsa-miR-95-5p, hsa-miR-329-5p, hsa-miR-19b-2-5p circRNA-miRNA predicted circRNA PDS5B circRNA homo sapiens PDS5B hsa_circ_0004494 AGCCTTGCTTCCTGTTTTACATCACAAATCTAAAAAAGGACCCCCCCGTCAAGCCAAATATGCCATTCATTGTATCCATGCGATATTTTCTAGTAAAGAGACCCAGTTTGCACAGATATTTGAGCCTCTGCATAAGAGCCTAGATCCAAGCAACCTGGAACATCTCATAACACCATTGGTTACTATTGGTCATATTGCTCTCCTTGCACCTGATCAATTTGCTGCTCCTTTGAAATCTTTGGTAGCTACTTTCATTGTGAAAGATCTTCTCATGAATGATCGG 25558066 Analysis of intron sequences reveals hallmarks of circular RNA biogenesis in animals. Ivanov A, Memczak S, Wyler E, Torti F, Porath HT, Orejuela MR, Piechotta M, Levanon EY, Landthaler M, Dieterich C, Rajewsky N. Cell Rep. 2015 This circRNA with top H score and high/medium expression of the host transcript was (1) resistant to RNase R and (2) had the predicted head-to-tail junctions, as validated by Sanger sequencing, suggesting that the circRNA exists in circularized form in HEK293 cells. qRT-PCR, sanger sequencing HEK293 cells hsa_circ_100219 circRNA homo sapiens FAF1 hsa_circ_0004619 GAGAGATTAAACAGATTCTAGAAAATGAACTTCAGATACCTGTGTCCAAAATGCTGTTAAAAGGCTGGAAGACGGGAGATGTGGAAGACAGTACGGTCCTAAAATCTCTACACTTGCCAAAAAACAACAGTCTTTATGTCCTTACACCAGATTTGCCACCACCTTCATCATCTAGTCATGCTGGTGCCCTGCAGGAGTCATTAAATCAAAACTTCATGCTGATCATCACCCACCGAGAAGTCCAGCGGGAGTACAACCTGAACTTCTCAGGAAGCAGTACTATTCAAGAGGTAAAGAGAAATGTGTATGACCTTACAAGTATCCCCGTTCGCCACCAATTATGGGAGGGCTGGCCAACTTCTGCTACAGACGACTCA breast cancer 28484086 Identification of circular RNAs as a promising new class of diagnostic biomarkers for human breast cancer. Lü L, Sun J, Shi P, Kong W, Xu K, He B, Zhang S, Wang J. Oncotarget. 2017 downregulated microarray, qRT-PCR Breast cancer lesions and adjacent normal-appearing tissues area under the curve (AUC) is 0.78 Breast cancer lesions and adjacent normal-appearing tissues hsa_circRNA_103110 circRNA homo sapiens NRIP1 hsa_circ_0004771 GAAGTGTTTGGATTGTGAGCTATTTCAGAACTGTTCTCAGGACTCATTATTTTAACATTTGGGAGAAACACAGCCAGAAGATGCACACTTGACTGAAGGAGGACAGGGAATCTGAAGACTCCGGATGACATCAGAGCTACTTTTCAACAGCCTTCTCAATTTTCTTTCTCAGAAAGCAGAGGCTCAGAGCTTGGAGACAGACG papillary thyroid carcinoma 28288173 Microarray profiling of circular RNAs in human papillary thyroid carcinoma. Peng N, Shi L, Zhang Q, Hu Y, Wang N, Ye H. PLoS One. 2017 upregulated microarray, qRT-PCR PTC tumors, matching contralateral normal samples, benign thyroid lesions (i.e., follicular adenoma samples and multinodular goiter samples) hsa-miR-653-5p, hsa-miR-339-5p, hsa-miR-330-5p, hsa-miR-595, hsa-miR-629-3p circRNA-miRNA predicted hsa_circ_103110 circRNA homo sapiens NRIP1 hsa_circ_0004771 GAAGTGTTTGGATTGTGAGCTATTTCAGAACTGTTCTCAGGACTCATTATTTTAACATTTGGGAGAAACACAGCCAGAAGATGCACACTTGACTGAAGGAGGACAGGGAATCTGAAGACTCCGGATGACATCAGAGCTACTTTTCAACAGCCTTCTCAATTTTCTTTCTCAGAAAGCAGAGGCTCAGAGCTTGGAGACAGACG breast cancer 28484086 Identification of circular RNAs as a promising new class of diagnostic biomarkers for human breast cancer. Lü L, Sun J, Shi P, Kong W, Xu K, He B, Zhang S, Wang J. Oncotarget. 2017 elevated in breast cancer tissues microarray, qRT-PCR Breast cancer lesions and adjacent normal-appearing tissues area under the curve (AUC) is 0.63 Breast cancer lesions and adjacent normal-appearing tissues hsa_circRNA_101356 circRNA homo sapiens SAMD4A hsa_circ_0004846 GAATCATTAACCAATGGCAACAGGAATCCAAGGATAAAGTGATTTCCCTCCTGTTAACTCATCTGCCTTTGCTGAAGCCAGGAAACCTCGACGCGAAAGTAGAATATATGAAACTGCTGCCCAAAATCCTGGCTCACTCTATTGAACACAACCAGCACATTGAGGAGAGCAGGCAGCTGCTGTCCTATGCTTTGATACATCCAGCCACTTCGTTAGAAGACCGTAGTGCTTTAGCCATGTGGCTGAATCACTTGGAGGACCGCACGTCGACCAGCTTTGGTGGCCAGAACCGAGGCCGCTCAGACTCTGTGGATTATGGACAGACACACTACTATCACCAAAGACAGAACTCTGATGACAAGCTCAATGGGTGGCAGAACTCTCGGGATTCTGGGATTTGCATCAATGCCTCCAACTGGCAGGACAAAAGCATGGGGTGTGAGAATGGCCATGTGCCCCTCTACTCCTCCTCATCTGTCCCCACCACAATCAATACGATTGGAACCAGCACAAGTACAA papillary thyroid carcinoma 28288173 Microarray profiling of circular RNAs in human papillary thyroid carcinoma. Peng N, Shi L, Zhang Q, Hu Y, Wang N, Ye H. PLoS One. 2017 upregulated microarray, qRT-PCR PTC tumors, matching contralateral normal samples, benign thyroid lesions (i.e., follicular adenoma samples and multinodular goiter samples) hsa-miR-148b-5p, hsa-miR-330-3p, hsa-miR-29b-1-5p, hsa-miR-646, hsa-miR-660-5p circRNA-miRNA predicted hsa_circ_0005015 circRNA homo sapiens HAS2 hsa_circ_0005015 ATGCATTGTGAGAGGTTTCTATGTATCCTGAGAATAATTGGAACCACACTCTTTGGAGTCTCTCTCCTCCTTGGAATCACAGCTGCTTATATTGTTGGCTACCAGTTTATCCAAACGGATAATTACTATTTCTCTTTTGGACTGTATGGTGCCTTTTTGGCATCACACCTCATCATCCAAAGCCTGTTTGCCTTTTTGGAGCACCGAAAAATGAAAAAATCCCTAGAAACCCCCATAAAGTTGAACAAAACAGTTGCCCTTTGCATCGCTGCCTATCAAGAAGATCCAGACTACTTAAGGAAATGTTTGCAATCTGTGAAAAGGCTAACCTACCCTGGGATTAAAGTTGTCATGGTCATAGATGGGAACTCAGAAGATGACCTTTACATGATGGACATCTTCAGTGAAGTCATGGGCAGAGACAAATCAGCCACTTATATCTGGAAGAACAACTTCCACGAAAAGGGTCCCGGTGAGACAGATGAGTCACATAAAGAAAGCTCGCAACACGTAACGCAATTGGTCTTGTCCAACAAAAGTATCTGCATCATGCAAAAATGGGGTGGAAAAAGAGAAGTCATGTACACAGCCTTCAGAGCACTGGGACGAAGTGTGGATTATGTACAG Diabetes Retinopathy 29288268 Identification and Characterization of Circular RNAs as a New Class of Putative Biomarkers in Diabetes Retinopathy. Zhang SJ, Chen X, Li CP, Li XM, Liu C, Liu BH, Shan K, Jiang Q, Zhao C, Yan B. Invest Ophthalmol Vis Sci. 2017 Upregulated in diabetic human retinas compared to nodiabetic retinas. microarray, qRT-PCR diabetic human retinas, nodiabetic retinas miR-519d-3p circRNA-miRNA human retinal vascular endothelial cells luciferase reporter assay Luciferase activity assays showed that miR-519d-3p¡ªbut not miR-6505-3p, miR-548an, miR-498, or miR-758¡ªmimicked transfection and decreased the activity of LUC-circ_0005015 after 48 hours transfection. MMP-2, STAT3, and XIAP hsa_circ_0005075 circRNA homo sapiens EIF4G3 hsa_circ_0005075 AATTCCTAGAGGACCTGTGCAACAACCTCTTGAGGATCGAATCTTCACTCCCGCTGTCTCAGCAGTCTACAGCACGGTAACACAAGTGGCAAGACAGCCGGGAACCCCTACCCCATCCCCTTATTCAGCACATGAAATAAACAAGGGGCATCCAAATCTTGCGGCAACGCCCCCGGGACATGCATCGTCCCCTGGACTCTCTCAA hepatocellular carcinoma 27258521 Comprehensive Circular RNA Profiling Reveals That hsa_circ_0005075, a New Circular RNA Biomarker, Is Involved in Hepatocellular Crcinoma Development. Shang X, Li G, Liu H, Li T, Liu J, Zhao Q, Wang C. Medicine (Baltimore). 2016 upregulated in HCC microarray, qRT-PCR HCC and adjacent normal liver tissues the area under the ROC curve (AUROC) was 0.94 HCC and adjacent normal liver tissues hsa_circ_0005105 circRNA homo sapiens SEC24A hsa_circ_0005105 TTACGACCACCTCAGCCTCCAGTGTATCTCTTTGTATTTGATGTGTCTCACAATGCAGTCGAAACTGGATACTTGAATTCAGTTTGCCAGAGTTTGTTAGACAATCTGGATTTGCTTCCTGGCAACACTAGAACAAAAATTGGCTTCATAACATTTGACAGTACAATCCATTTCTACGGTCTTCAGGAAAGTCTCTCTCAACCTCAGATGCTAATAGTTTCAGATATTGAAG Osteoarthritis 28276108 CircRNA hsa_circ_0005105 upregulates NAMPT expression and promotes chondrocyte extracellular matrix degradation by sponging miR-26a. Wu Y, Zhang Y, Zhang Y, Wang JJ. Cell Biol Int. 2017 IL-1beta can significantly promote hsa_circ_0005105 expression in chondrocytes in a time dependent manner. qRT-PCR chondrocytes hsa_circ_0005105 can inhibit the expression of type II collagen and aggrecan, promote the expression of MMP-13 and ADAMTS-4, and the generation of PGE2, IL-6, and IL-8, but the linear sequence of hsa_circ_0005105 cannot. loss of function, gain of function chondrocytes miR-26a circRNA-miRNA chondrocytes luciferase reporter assay the results of dualluciferase reporter assay confirmed that hsa_circ_0005105 had miR-26a binding sites NAMPT hsa_circ_0005267 circRNA homo sapiens C14orf118 hsa_circ_0005267 TGAAACCAGCAGTGTGTGTAGCAGCAGTGACACTGGGCTCTTTACCAATGATGAAGGGCGACAAGGTGATGACGAACAGAGTGATTGGTTCTATGAAGGAGAATGTGTCCCAGGATTCACTGTCCCTAATCTTCTGCCCAAGTGGGCTCCTGATCATTGTTCTGAAGTAGAAAGAATGGATTCTGGATTGGATAAATTTTCAGATTCCACATTCCTTTTACCTTCTCGGCCAGCTCAAAGAGGGTACCATACTCGCTTGAATCGTCTACCTGGAGCTGCAGCTCGATGCCTCAGAAAGGGGCGAAGAAGGCTGGTTGGGAAGGAGACCAGCATAAACACTTTGGGGACTGAGAGGATAAGCCATATCATTAGTGACCCTCGGCAGAAAGAAAAGAATAAAGCGTTGGCTTCTGATTTTCCTCACATTTCTGCTTGTGCACATGAGTTCAATCCCCTGTCTCCCCTTTACTCCCTGGATGTTCTTGCCGATGCTTCTCACCGAAGGTGTTCACCAGCACACTGCTCTGCCAG primary great saphenous vein varicosities 29577902 Identification of aberrant circular RNA expression and its potential clinical value in primary great saphenous vein varicosities. Zhang W, Li L, Si Y, Shi Z, Zhu T, Zhuang S, Fu W. Biochem Biophys Res Commun. 2018 Significantly lower in the PGSVV group than in the control group. RNA-seq, qRT-PCR vein samples of primary great saphenous vein varicosities patients hsa_circ_0005397 circRNA homo sapiens RHOT1 hsa_circ_0005397 GTTCCTCCCCGGGCAGAAGAAATCACCATTCCAGCTGATGTCACCCCAGAGAGAGTTCCAACACACATTGTAGATTACTCAGAAGCAGAACAGAGTGATGAACAACTTCATCAAGAAATATCTCAGGCTAATGTCATCTGTATAGTGTATGCCGTTAACAACAAGCATTCTATTGATAAGGTAACAAGTCGATGGATTCCTCTCATAAATGAAAGAACAGACAAAGACAGCAG pancreatic ductal adenocarcinoma 27997903 Circular RNA Expression Profile of Pancreatic Ductal Adenocarcinoma Revealed by Microarray. Li H, Hao X, Wang H, Liu Z, He Y, Pu M, Zhang H, Yu H, Duan J, Qu S. Cell Physiol Biochem. 2016 up microarray, qRT-PCR PDAC samples and corresponding normal tissues hsa_circ_0005529 circRNA homo sapiens VPS33B hsa_circ_0005529 GTGCTAGAGCGGCGAAGCTGGCAGGGCCTTGATGAGGTGGTACGGCTGCTCAACTGCAGTGACTTTGCATTCACAGATATGACTAAGGAAGACAAGGCTTCCAGTGAGTCCCTGCGCCTCATCTTGGTGGTGTTCTTGGGTGGTTGTACATTCTCTGAGATCTCAGCCCTCCGGTTCCTGGGCAGAGAGAAAG gastric cancer 28737829 Expression profile of circular RNAs in human gastric cancer tissues. Huang YS, Jie N, Zou KJ, Weng Y. Mol Med Rep. 2017 upregulated microarray, qRT-PCR GC tissues and adjacent normal tissues hsa_circ_0005667 circRNA homo sapiens ZNF124 hsa_circ_0005667 AACTCGGTTGCCTTTGAGGATGTGGCTGTGAACTTCACCCAGGAGGAGTGGGCTTTGTTGGATCCTTCCCAGAAGAATCTCTATAGAGACGTGATGCAGGAAACCTTCAGGAATCTGGCTTCCATAGGAAACAAAGGGGAAGACCAGAGCATTGAAGATCAGTACAAAAATTCTTCAAGAAATCTAAGTTCATTTCAGATACATCAGAGAAATCACACTGGAGAGAAACCCTATGAATGTATGGAATGTGGGAAAGCCTTAGGTTTTTCCCGTTCTCTTAATAGACATAAAAGGATTCACACTGGAGAAAAACGCTATGAATGTAAGCAATGTGGGAAAGCCTTCAGTCGTTCCAGTCACCTTCGTGACCATGAAAGAACTCATACTGGAGAGAAACCCTATGAAT endometrial cancer 29334253 Circular RNA expression in extracellular vesicles isolated from serum of patients with endometrial cancer. Xu H, Gong Z, Shen Y, Fang Y, Zhong S. Epigenomics. 2018 up RNA-seq, northern blots extracellular vesicles isolated from serum of patients with endometrial cancer hsa_circ_0005785 circRNA homo sapiens ANAPC7 hsa_circ_0005785 TGAGTTATTCTCCCCACCTCAGAAGTACCAGCTTTTGGTGTATCATGCAGATTCTCTCTTTCATGATAAGGAATATCGGAATGCTGTGAGTAAGTATACCATGGCTTTACAGCAGAAGAAAGCGCTAAGTAAAACTTCAAAAGTGAGACCTTCAACTGGAAATTCTGCATCTACTCCACAAAGTCAGTGTCTTCCATCTGAAATTGAAGTGAAATACAAAATGGCTGAATGTTATACAATGCTAAAACAAGATAAAGATGCCATTGCTATACTTGATGGGATCCCTTCAAGACAAAGAACTCCCAAAATAAACATGATGCTGGCAAACCTGTACAAGAAGGCTGGTCAGGAGCGCCCTTCAGTCACCAGCTATAAGGAGGTGCTGAGGCAGTGCCCATTAGCCCTTGATGCCATTCTAGGCTTGTTGTCCCTTTCTGTAAAAGGGGCAGAGGTGGCATCCATGACAATGAATGTGATCCAAACCGTGCCTAACTTGGACTGGCTCTCTGTGTGGATCAAAGCGTATGCTTTTGTGCACACTGGTGACAACTCAAGAGCAATCAGTACCATCTGTTCACTAGAGAAAAAATCCTTATTGCGAGATAACGTGGACCTATTGGGAAGCTTGGCAGATCTGTACTTCAGAGCTGGAGACAATAAAAACTCTGTCCTCAAGTTTGAACAGGCACAGATGTTGGATCCTTATCTGATAAAAGGAATGGATGTATATGGCTACCTACTGGCACGAGAAGGGCGGCTAGAGGATGTTGAGAACCTTGGATGCCGCCTTTTCAATATCTCTGATCAGCATGCAGAACCGTGGGTGGTTTCTGGCTGTCACAGCTTCTATAGCAAACGCTACTCCCGGGCCCTCTATTTAGGAGCCAAGGCCATTCAGCTGAACAGTAATAGTGTTCAAGCTCTGCTACTTAAGGGAGCAGCACTTAGGAACATGGGCAGAGTCCAAGAAGCAATAATCCACTTTCGGGAGGCCATACGGCTCGCACCTTGTCGCTTAGATTGTTATGAAG pancreatic ductal adenocarcinoma 27997903 Circular RNA Expression Profile of Pancreatic Ductal Adenocarcinoma Revealed by Microarray. Li H, Hao X, Wang H, Liu Z, He Y, Pu M, Zhang H, Yu H, Duan J, Qu S. Cell Physiol Biochem. 2016 down microarray, qRT-PCR PDAC samples and corresponding normal tissues hsa_circ_0005836 circRNA homo sapiens TRAPPC6B hsa_circ_0005836 GTTTACAAAAGATACTGCAAGGTTCAAGGATGAGTTAGATATCATGAAGTTCATTTGTAAAGATTTTTGGACTACGGTATTCAAGAAACAAATCGACAATCTAAGGACAAATCATCAGGGCATCTATGTACTTCAGGACAACAAATTTCGCCTGCTTACTCAGATGTCTGCAGGAAAACAGTATTTAGAACATGCATCTAAG Active Pulmonary Tuberculosis 28846924 The circular RNA of peripheral blood mononuclear cells: Hsa_circ_0005836 as a new diagnostic biomarker and therapeutic target of active pulmonary tuberculosis. Zhuang ZG, Zhang JA, Luo HL, Liu GB, Lu YB, Ge NH, Zheng BY, Li RX, Chen C, Wang X, Liu YQ, Liu FH, Zhou Y, Cai XZ, Chen ZW, Xu JF. Mol Immunol. 2017 significantly decreased in APTB patients compared to HC patients. RNA-seq, qRT-PCR APTB patients, HC patients. hsa_circ_0005912 circRNA homo sapiens FIP1L1 hsa_circ_0005912 GTACAGCAGGGAAGAACTGGAAACTCAGAGAAAGAAACTGCCCTTCCATCTACAAAAGCTGAGTTTACTTCTCCTCCTTCTTTGTTCAAGACTGGGCTTCCACCGAGCAGAAACAGCACTTCTTCTCAGTCTCAGACAAGTACTGCCTCCAGAAAAGCCAATTCAAGCGTTGGGAAGTGGCAGGATCGATATGGGAGGGCCGAATCACCTGATCTAAGGAGATTACCTGGGGCAATTGATGTTATCGGTCAGACTATAACTATCAGCCGAGTAGAAGGCAGGCGACGGGCAAATGAGAACAGCAACATACAGGTCCTTTCTGAAAGATCTGCTACTGAAGTAGACAACAATTTTAGCAAACCACCTCCGTTTTTCCCTCCAGGAGCTCCTCCCACTCACCTTCCACCTCCTCCATTTCTTCCACCTCCTCCGACTGTCAGCACTGCTCCACCTCTGATTCCACCACCGG basal cell carcinoma 27097056 Circular RNA expression in basal cell carcinoma. Sand M, Bechara FG, Sand D, Gambichler T, Hahn SA, Bromba M, Stockfleth E, Hessam S. Epigenomics. 2016 up microarray, qRT-PCR, FISH nodular BCC and nonlesional skin tissues hsa_circ_0005927 circRNA homo sapiens VDAC3 hsa_circ_0005927 AAAGAAGAGTGGGAAATTGAAGGCCTCCTATAAACGGGATTGTTTTAGTGTTGGCAGTAATGTTGATATAGATTTTTCTGGACCAACCATCTATGGCTGGGCTGTGTTGGCCTTCGAAGGGTGGCTTGCTGGCTATCAGATGAGTTTTGACACAGCCAAATCCAAACTGTCACAGAATAATTTCGCCCTGGGTTACAAGGCTGCGGACTTCCAGCTGCACACACATGTGAACGATGGCACTGAATTTGGAGGTTCTATCTACCAGAAGGTGAATGAGAAGATTGAAACATCCATAAACCTTGCTTGGACAGCTGGGAGTAACAACACCCGTTTTGGCATTGCTGCTAAGTACATGCTGGATTGTAGAACTTCTCTCTCT gastric cancer 28737829 Expression profile of circular RNAs in human gastric cancer tissues. Huang YS, Jie N, Zou KJ, Weng Y. Mol Med Rep. 2017 downregulated microarray, qRT-PCR GC tissues and adjacent normal tissues hsa_circ_0005931 circRNA homo sapiens SLC25A25 hsa_circ_0005931 AAAATTGTACAAGCTGGAGATAAGGACCTTGATGGGCAGCTAGACTTTGAAGAATTTGTCCATTATCTCCAAGATCATGAGAAGAAGCTGAGGCTGGTGTTTAAGAGTTTGGACAAAAAGAATGATGGACGCATTGACGCGCAGGAGATCATGCAGTCCCTGCGGGACTTGGGAGTCAAGATATCTGAACAGCAGGCAGAAAAAATTCTCAAGAGCATGGATAAAAACGGCACGATGACCATTGACTGGAACGAGTGGAGAGACTACCACCTCCTCCACCCCGTGGAAAACATCCCCGAGATCATCCTCTACTGGAAGCATTCCACGATCTTTGATGTGGGTGAGAATCTAACGGTCCCGGATGAGTTCACAGTGGAGGAGAGGCAGACGGGGATGTGGTGGAGACACCTGGTGGCAGGAGGTGGGGCAGGGGCCGTATCCAGAACCTGCACGGCCCCCCTGGACAGGCTCAAGGTGCTCATGCAGGTCCATGCCTCCCGCAGCAACAACATGGGCATCGTTGGTGGCTTCACTCAGATGATTCGAGAAGGAGGGGCCAGGTCACTCTGGCGGGGCAATGGCATCAACGTCCTCAAAATTGCCCCCGAATCAGCCATCAAATTCATGGCCTATGAGCAGATCAAGCGCCTTGTTGGTAGTGACCAGGAGACTCTGAGGATTCACGAGAGGCTTGTGGCAGGGTCCTTGGCAGGGGCCATCGCCCAGAGCAGCATCTACCCAATGGAGGTCCTGAAGACCCGGATGGCGCTGCGGAAGACAGGCCAGTACTCAGGAATGCTGGACTGCGCCAGGAGGATCCTGGCCAGAGAGGGGGTGGCCGCCTTCTACAAAGGCTATGTCCCCAACATGCTGGGCATCATCCCCTATGCCGGCATCGACCTTGCAGTCTACGAGACGCTCAAGAATGCCTGGCTGCAGCACTATGCAGTGAACAGCGCGGACCCCGGCGTGTTTGTGCTCCTGGCCTGTGGCACCATGTCCAGTACCTGTGGCCAGCTGGCCAGCTACCCCCTGGCCCTAGTCAGGACCCGGATGCAGGCGCAAG hepatoblastoma 29414822 Expression Profiling Identifies Circular RNA Signature in Hepatoblastoma. Liu BH, Zhang BB, Liu XQ, Zheng S, Dong KR, Dong R. Cell Physiol Biochem. 2018 up microarray, qRT-PCR hepatoblastoma and adjacent normal liver samples circPTK2 circRNA homo sapiens PTK2 hsa_circ_0005982 AATATGACAGATACCTAGCATCTAGCAAAATAATGGCAGCTGCTTACCTTGACCCCAACTTGAATCACACACCAAATTCGAGTACTAAGACTCACCTGGGTACTGGTATGGAACGTTCTCCTGGTGCAATGGAGCGAGTATTAAAGGTCTTTCATTATTTTGAAAGCAATAGTGAGCCAACCACCTGGGCCAGTATTATCAGGCATGGAGATGCTACTGATGTCAGGGGCATCATTCAGAAGATAGTGGACAGTCACAAAGTAAAGCATGTGGCCTGCTATGGATTCCGCCTCAGTCACCTGCGGTCAGAGGAGGTTCACTGGCTTCACGTGGATATGGGCGTCTCCAGTGTGAGGGAGAAGTATGAGCTTGCTCACCCACCAGAGGAGTGGAAATATGAATTGAGAATTCGTTATTTGCCAAAAGGATTTCTAAACCAGTTTACTGAAGATAAGCCAACTTTGAATTTCTTCTATCAACAGGTGAAGAGCGATTATATGTTAGAGATAGCTGATCAAGTGGACCAGGAAATTGCTTTGAAGTTGGGTTGTCTAGAAATACGGCGATCATACTGGGAGATGCGGGGCAATGCACTAGAAAAGAAGTCTAACTATGAAGTATTAGAAAAAGATGTTGGTTTAAAGCGATTTTTTCCTAAGAGTTTACTGGATTCTGTCAAGGCCAAAACACTAAGAAAACTGATCCAACAAACATTTAGACAATTTGCCAACCTTAATAGAGAAGAAAGTATTCTGAAATTCTTTGAGATCCTGTCTCCAGTCTACAGATTTGATAAGGAATGCTTCAAGTGTGCTCTTGGTTCAAGCTGGATTATTTCAGTGGAACTGGCAATCGGCCCAGAAGAAGGAATCAGTTACCTAACGGACAAGGGCTGCAAT 28444238 High-purity circular RNA isolation method (RPAD) reveals vast collection of intronic circRNAs. Panda AC, De S, Grammatikakis I, Munk R, Yang X, Piao Y, Dudekula DB, Abdelmohsen K, Gorospe M. Nucleic Acids Res. 2017 circRNA junctions were indeed amplified and verifying the presence of backsplice sites in these transcripts. qRT-PCR HeLa hsa_circ_0005986 circRNA homo sapiens PRDM2 hsa_circ_0005986 AACACTACTGAGCCTGTGGCGGCCACCGAGACCCTGGCTGAGGTACCCGAACATGTGCTGCGAGGACTTCCGGAGGAAGTGAGGCTTTTCCCTTCTGCTGTTGACAAGACCCGGATTGGTGTCTGGGCCACTAAACCAATTTTAAAAGGCAAAAAATTTGGGCCATTTGTTGGTGATAAGAAAAAAAGATCTCAGGTTAAGAATAATGTATACATGTGGGAGGTGTATTACCCAAATTTGGGATGGATGTGCATTGATGCCACTGATCCAGAGAAGGGAAACTGGCTGCGATATGTGAATTGGGCTTGCTCAGGAGAAGAGCAAAATTTATTCCCACTGGAAATCAACAGAGCCATTTACTATAAAACTTTAAAG hepatocellular carcinoma 28410211 Hsa_circ_0005986 inhibits carcinogenesis by acting as a miR-129-5p sponge and is used as a novel biomarker for hepatocellular carcinoma. Fu L, Chen Q, Yao T, Li T, Ying S, Hu Y, Guo J. Oncotarget. 2017 Hsa_circ_0005986 was downregulated in HCC qRT-PCR HCC tissues and para-tumorous tissues, LO2, HepG2, SMCC7721, and Huh7 Hsa_circ_0005986 regulates the cell cycle and cell proliferation loss of function HepG2 and Huh7 miR-129-5p circRNA-miRNA HepG2 luciferase reporter assay Here, our study further verified the direct interaction between hsa_circ_0005986 and miR-129-5p via dual luciferase reporter assays. NOTCH1 hsa_circ_0006022 circRNA homo sapiens LYN hsa_circ_0006022 GCATGGAGAATGGTGGAAAGCAAAGTCCCTTTTAACAAAAAAAGAAGGCTTCATCCCCAGCAACTATGTGGCCAAACTCAACACCTTAGAAACAGAAGAGTGGTTTTTCAAGGATATAACCAGGAAGGACGCAGAAAGGCAGCTTTTGGCACCAGGAAATAGCGCTGGAGCTTTCCTTATTAGAGAAAGTGAAACATTAAAAGGAAGCTTCTCTCTGTCTGTCAGAGACTTTGACCCTGTGCATGGTGATGTTATTAAGCACTACAAAATTAGAAGTCTGGATAATGGGGGCTATTACATCTCTCCACGAATCACTTTTCCCTGTATCAGCGACATGATTAAACATTACCAAAAGCAGGCAGATGGCTTGTGCAGAAGATTGGAGAAGGCTTGTATTAGTCCCAAGCCACAGAAGCCATGGGATAAAGATGCCTGGGAGATCCCCCGGGAGTCCATCAAGTTGGTGAAAAGGCTTGGCGCTGGGCAGTTTGGGGAAGTCTGGATGG gastric cancer 28639908 Circular RNAs play an important role in late-stage gastric cancer: Circular RNA expression profiles and bioinformatics analyses. Fang Y, Ma M, Wang J, Liu X, Wang Y. Tumour Biol. 2017 upregulated in GC microarray, qRT-PCR III stage gastric cancer and paired paracarcinoma tissue hsa_circ_0006174 circRNA homo sapiens RAD23B hsa_circ_0006174 GCAAAATCCTCAATGATGATACTGCTCTCAAAGAATATAAAATTGATGAGAAAAACTTTGTGGTGGTTATGGTGACCAAACCCAAAGCAGTGTCCACACCAGCACCAGCTACAACTCAGCAGTCAGCTCCTGCCAGCACTACAGCAGTTACTTCCTCCACCACCACAACTGTGGCTCAGGCTCCAACCCCTGTCCCTGCCTTGGCCCCCACTTCCACACCTGCATCCATCACTCCAGCATCAGCGACAGCATCTTCTGAACCTGCACCTGCTAGTGCAGCTAAACAAGAGAAGCCTGCAGAAAAGCCAGCAGAGACACCAGTGGCTACTAGCCCAACAGCAACTGACAG Colorectal cancer 28656150 Microarray Analysis of Circular RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells. Xiong W, Ai YQ, Li YF, Ye Q, Chen ZT, Qin JY, Liu QY, Wang H, Ju YH, Li WH, Li YF. Biomed Res Int. 2017 down microarray, qRT-PCR CRR (chemoradiation resistance)-HCT116 and the parental HCT116 cells hsa_circ_0006427 circRNA homo sapiens BCAR3 hsa_circ_0006427 ATCACAAGGTTAGAAAAGACGTGGACTGCTCTGCGGCACCAGTACACCCAAACTGCCATTCTCTATGAGAAACAGCTGAAGCCCTTCAGCAAACTCCTGCATGAAGGCAGAGAGTCCACATGTGTTCCCCCAAACAATGTATCAGTCCCACTGCTGATGCCGCTTGTGACGTTAATGGAGCGCCAGGCTGTGACTTTTGAAGGAACCGACATGTGGGAAAAAAACGACCAGAGCTGTGAAATCATGCTGAACCATTTGGCAACAGCGCGATTCATGGCCGAGGCTGCAGACAGCTACCGGATGAATGCTGAGAGGATCCTGGCAG primary great saphenous vein varicosities 29577902 Identification of aberrant circular RNA expression and its potential clinical value in primary great saphenous vein varicosities. Zhang W, Li L, Si Y, Shi Z, Zhu T, Zhuang S, Fu W. Biochem Biophys Res Commun. 2018 Significantly lower in the PGSVV group than in the control group. RNA-seq, qRT-PCR vein samples of primary great saphenous vein varicosities patients hsa_circ_0006528 circRNA homo sapiens PRELID2 hsa_circ_0006528 GTTTCCACGCTTTGAGAAGGACTGAATGAGATCATGCGCATGGCAGCTTCTCTAGGATAGCACCCTGCGTGAACACAGTAGCTGCTCAGTTAAGTCTTTGATGGGTGTGATCCTGATTCAGCTTGATCAATTCTGCAGTCATACTGGATTGTGTTTGAAAAGGTGTCCAGAAAAACCTGGCCATCTGCCTCCTGTCTTCCCAGTACCCCAACCCCATGGATAAAAATGTCATCTCAGTAAAAATCATGGAGGAAAAAAGAGATGAATCAACAGGGGTCATCTACAGAAAGAGGATTGCAATCTGTCAGAACGTGGTTCCAGAAATTTTAAGGAAGGTGAGCATTTTGAAAGTACCTAATATCCAATTAGAAGAGGAGTCATGGCTCAATCCTCGGGAAAGAAACATGGCCATACGGAGTCACTGCCTTACGTGGACACAGTATGCATCCATGAAGGAAGAGTCTGTCTTCCGGGAAAGTATGGAAAACCCAAATTG breast cancer 28803498 Screening circular RNA related to chemotherapeutic resistance in breast cancer. Gao D, Zhang X, Liu B, Meng D, Fang K, Guo Z, Li L. Epigenomics. 2017 up microarray, qRT-PCR MCF-7 and MDA-MB-231, ADM-resistant cell lines (MCF-7/ADM and MDA-MB-231/ADM), ADM resistant and ADM sensitive tissues Circ 0006528 is correlated with ADM sensitivity in breast cancer ADM resistant and ADM sensitive tissues miR-7-5p circRNA-miRNA ADM-resistant human breast cancer tissues, MCF-7/ADM and MDA-MB-231/ADM cell expression miR-7-5p expression was increased after knocking down circ 0006528. We observed a negative correlation between circ 0006528 and miR-7¨C5p expression in ADM-resistant human breast cancer tissues. Raf1 hsa_circ_0006623 circRNA homo sapiens PABPC1 hsa_circ_0006623 CATTCCAAAATATGCCCGGTGCTATCCGCCCAGCTGCTCCTAGACCACCATTTAGTACTATGAGACCAGCTTCTTCACAGGTTCCACGAGTCATGTCAACACAGCGTGTTGCTAACACATCAACACAGACAATGGGTCCACGTCCTGCAGCTGCAGCCGCTGCAGCTACTCCTGCTGTCCGCACCGTTCCACAGTATAAATATGCTGCAGGAGTTCGCAATCCTCAGCAACATCTTAATGCACAGCCACAAGTTACAATGCAACAG hepatocellular carcinoma 29144509 Circular RNA expression is suppressed by androgen receptor (AR)-regulated adenosine deaminase that acts on RNA (ADAR1) in human hepatocellular carcinoma. Shi L, Yan P, Liang Y, Sun Y, Shen J, Zhou S, Lin H, Liang X, Cai X. Cell Death Dis. 2017 upregulated more than fivefold as revealed by circRNA microarray after AR knocking down in MHCC-99h cells microarray, qRT-PCR MHCC-97h, LM3 and LO5 cells hsa_circ_0006633 circRNA homo sapiens FGGY hsa_circ_0006633 AAAGTTGTACAAGGGATTGATTTAAACCAAATTCGAGGACTTGGGTTTGATGCCACGTGTTCTCTGGTTGTTTTGGATAAGCAGTTTCACCCATTACCAGTCAACCAGGAAGGGGATTCCCATCGAAACGTCATCATGTGGCTGGACCATCGAGCAGTCAGTCAAGTTAACAGGATCAATGAGACCAAGCACAGTGTCCTCCAGTACGTCGGGGGGGTGATGTCTGTGGAAATGCAGGCCCCGAAACTTCTGTGGCTGAAAGAGAACTTGAGAGAGATTTGCTGGGATAAGGCGGGACATTTCTTTGATCTCCCGGACTTCTTATCGTGGAAGGCAACAGGTGTCACAGCACG Gastric cancer 28656881 Low expression of hsa_circ_0006633 in human gastric cancer and its clinical significances. Lu R, Shao Y, Ye G, Xiao B, Guo J. Tumour Biol. 2017 hsa_circ_0006633 expression levels were significantly decreased in gastric cancer. qRT-PCR gastric cancer tissues and their adjacent non-tumorous tissues 5 cm from the edge of the tumor, GES-1, HGC-27, SGC-7901, MGC-803, and AGS Low expression of hsa_circ_0006633 in human gastric cancer tissues was associated with distal metastasis (p = 0.037) and tissue CEA level (p = 0.041). The area under the curve was up to 0.741. gastric cancer tissues and their adjacent non-tumorous tissues 5 cm from the edge of the tumor hsa_circ_0006913 circRNA homo sapiens ARID1A hsa_circ_0006913 GATCTATCTGGTTCAATAGATGACCTCCCCATGGGGACAGAAGGAGCTCTGAGTCCTGGAGTGAGCACATCAGGGATTTCCAGCAGCCAAGGAGAGCAGAGTAATCCAGCTCAGTCTCCTTTCTCTCCTCATACCTCCCCTCACCTGCCTGGCATCCGAGGCCCTTCCCCGTCCCCTGTTGGCTCTCCCGCCAGTGTTGCTCAGTCTCGCTCAGGACCACTCTCGCCTGCTGCAGTGCCAGGCAACCAGATGCCACCTCGGCCACCCAGTGGCCAGTCGGACAGCATCATGCATCCTTCCATGAACCAATCAAGCATTGCCCAAGATCGAGGTTATATGCAGAGGAACCCCCAGATGCCCCAGTACAGTTCCCCCCAGCCCGGCTCAGCCTTATCTCCGCGTCAGCCTTCCGGAGGACAGATACACACAGGCATGGGCTCCTACCAGCAGAACTCCATGGGGAGCTATGGTCCCCAGGGGGGTCAGTATGGCCCACAAGGTGGCTACCCCAGGCAGCCAAACTATAATGCCTTGCCCAATGCCAACTACCCCAGTGCAGGCATGGCTGGAGGCATAAACCCCATGGGTGCCGGAGGTCAAATGCATGGACAGCCTGGCATCCCACCTTATGGCACACTCCCTCCAGGGAGGATGAGTCACGCCTCCATGGGCAACCGGCCTTATGGCCCTAACATGGCCAATATGCCACCTCAGGTTGGGTCAGGGATGTGTCCCCCACCAGGGGGCATGAACCGGAAAACCCAAGAAACTGCTGTCGCCATGCATGTTGCTGCCAACTCTATCCAAAACAG pancreatic ductal adenocarcinoma 27997903 Circular RNA Expression Profile of Pancreatic Ductal Adenocarcinoma Revealed by Microarray. Li H, Hao X, Wang H, Liu Z, He Y, Pu M, Zhang H, Yu H, Duan J, Qu S. Cell Physiol Biochem. 2016 down microarray, qRT-PCR PDAC samples and corresponding normal tissues hsa_circ_0007006 circRNA homo sapiens DYM hsa_circ_0007006 ATAGCAGTCCTTTCCCCTCATCAATTCCACATGCCTTCCAGATCAACTTTAATAGTTTGTACACAGCTCTTTGTGAACAGCAGACATCTGATCAAGCAACTCTCCTCTTGTATACCTTGCTCCATCAAAATAGTAATATTAGAACATACATGTTGGCTCGCACAGATATGGAAAATCTTGTTTTACCAATTCTTGAGATTCTGTATCATGTTGAAGAAAGGAATTCACACCATGTGTATATGGCCCTTATAATATTGTTGATCCTTACGGAAGATGATGGCTTCAACAGATCCATTCATGAAGTGATACTAAAAAATATTACTTGGTATTCAGAACGAGTTTTAACTGAAATCTCCTTGGGGAGTCTCCTGATCCTGGTGGTAATAAGAACCATTCAATACAACATGACTAGGACACGAGACAAGTACCTTCACACAAATTGTTTGGCAGCTTTAGCAAATATGTCGGCACAGTTTCGTTCTCTCCATCAGTATGCTGCCCAGAGGATCATCAG Colorectal cancer 28656150 Microarray Analysis of Circular RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells. Xiong W, Ai YQ, Li YF, Ye Q, Chen ZT, Qin JY, Liu QY, Wang H, Ju YH, Li WH, Li YF. Biomed Res Int. 2017 up microarray, qRT-PCR CRR (chemoradiation resistance)-HCT116 and the parental HCT116 cells miR-628-5p, miR-653-5p, miR-654-3p, miR-300 circRNA-miRNA predicted hsa_circ_0007022 circRNA homo sapiens SAE1 hsa_circ_0007022 GCTGCGGGCCTCTCGGGTGCTTCTTGTCGGCTTGAAAGGACTTGGGGCTGAAATTGCCAAGAATCTCATCTTGGCAGGAGTGAAAGGACTGACCATGCTGGATCACGAACAGGTAACTCCAGAAGATCCCGGAGCTCAGTTCTTGATTCGTACTGGGTCTGTTGGCCGAAATAGGGCTGAAGCCTCTTTGGAGCGAGCTCAGAATCTCAACCCCATGGTGGATGTGAAGGTGGACACTGAGGATATAGAGAAGAAACCAGAGTCATTTTTCACTCAATTCGATGCTGTGTGTCTGACTTGCTGCTCCAGGGATGTCATAGTTAAAGTTGACCAGATCTGTCACAAAAATAGCATCAAGTTCTTTACAGGAGATGTTTTTGGCTACCATGGATACACATTTGCCAATCTAGGAGAGCATGAGTTTGTAGAGGAGAAAACTAAAGTTGCCAAAGTTAGCCAAGGAGTAGAAGATGGGCCCGACACCAAGAGAGCAAAACTTGATTCTTCTGAGACAACGATGGTCAAAAAGAAGGTGGTCTTCTGCCCTGTTAAAGAAGCCCTGGAGGTGGACTGGAGCAGTGAGAAAGCAAAGGCTGCTCTGAAGCGCACGACCTCCGACTACTTTCTCCTTCAAG male infertile diseases 27958373 Identification and characterization of human testis derived circular RNAs and their existence in seminal plasma. Dong WW, Li HM, Qing XR, Huang DH, Li HG. Sci Rep. 2016 To validate these predicted circRNAs, 55 circRNAs of different abundance and lengths were randomly chosen for subsequent RT-PCR validation. Divergent primers were designed for circRNA detection. Among the 55 circRNAs, 30 of them could be specifically amplified. qRT-PCR human testis hsa_circ_0007031 circRNA homo sapiens TUBGCP3 hsa_circ_0007031 TTTTTTGTAGCATCAGATCCAACAGTTAAAACAGATCGACTGTGGCACGACAAGTATACTTTGAGGAAATCGATGATTCCTTCGTTTATGACGATGGATCAGTCTAGGAAGGTCCTTTTGATAGGAAAATCAATAAATTTCTTGCACCAAGTTTGTCATGATCAGACTCCCACTACAAAGATGATAGCTGTGACCAAGTCTGCAGAGTCACCCCAGGACGCTGCAGACCTATTCACAGACTTGGAAAATGCATTTCAGGGGAAGATTGATGCTGCTTATTTTGAGACCAGCAAATACCTGTTGGATGTTCTCAATAAAAAGTACAGCTTGCTGGACCACATGCAGGCAATGAGGCGGTACCTGCTTCTTGGTCAAGGAGACTTTATAAGGCACTTAATGGACTTGCTAAAACCAGAACTTGTCCGTCCAGCTACGACTTTGTATCAGCATAACTTGACTGGAATTCTAGAAACCGCTGTCAGAGCCACCAACGCACAGTTTGACAGTCCTGAGATCCTGCGAAGGCTGGACGTGCGGCTGCTGGAGGTCTCTCCAGGTGACACTGGATGGGATGTCTTCAGCCTCGATTATCATGTTGACGGACCAATTGCAACTGTGTTTACTCGAGAATGTATGAGCCACTACCTAAGAGTATTTAACTTCCTCTGGAGGGCGAAGCGGATGGAATACATCCTCACTGACATACGGAAGGGACACATGTGCAATGCAAAGCTCCTGAGAAACATGCCAGAGTTCTCCGGGGTGCTGCACCAGTGTCACATTTTGGCCTCTGAGATGGTCCATTTCATTCATCAGATGCAGTATTACATCACATTTGAGGTGCTTGAATGTTCTTGGGATGAGCTTTGGAACAAAGTCCAGCAGGCCCAGGATTTGGATCACATCATTGCTGCACACGAGGTGTTCTTAGACACCATCATCTCCCGCTGCCTGCTGGACAGTGACTCCAGG Colorectal cancer 28656150 Microarray Analysis of Circular RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells. Xiong W, Ai YQ, Li YF, Ye Q, Chen ZT, Qin JY, Liu QY, Wang H, Ju YH, Li WH, Li YF. Biomed Res Int. 2017 up microarray, qRT-PCR CRR (chemoradiation resistance)-HCT116 and the parental HCT116 cells miR-885-3p, miR-324-5p, miR-640, miR-103a-3p circRNA-miRNA predicted circCNOT1 circRNA homo sapiens CNOT1 hsa_circ_0007079 GAGTGTTTCTCAGGAGCTATCAGAAACTATCCTCACCATGGTAGCCAATTGCAGTAATGTTATGAATAAGGCCAGACAACCACCACCTGGAGTTATGCCAAAAGGACGTCCTCCTAGTGCTAGCAGCTTAGATGCCATTTCTCCTGTTCAG 28444238 High-purity circular RNA isolation method (RPAD) reveals vast collection of intronic circRNAs. Panda AC, De S, Grammatikakis I, Munk R, Yang X, Piao Y, Dudekula DB, Abdelmohsen K, Gorospe M. Nucleic Acids Res. 2017 circRNA junctions were indeed amplified and verifying the presence of backsplice sites in these transcripts. qRT-PCR HeLa hsa_circ_0007219 circRNA homo sapiens SAE1 hsa_circ_0007219 GTAACTCCAGAAGATCCCGGAGCTCAGTTCTTGATTCGTACTGGGTCTGTTGGCCGAAATAGGGCTGAAGCCTCTTTGGAGCGAGCTCAGAATCTCAACCCCATGGTGGATGTGAAGGTGGACACTGAGGATATAGAGAAGAAACCAGAGTCATTTTTCACTCAATTCGATGCTGTGTGTCTGACTTGCTGCTCCAGGGATGTCATAGTTAAAGTTGACCAGATCTGTCACAAAAATAGCATCAAGTTCTTTACAGGAGATGTTTTTGGCTACCATGGATACACATTTGCCAATCTAGGAGAGCATGAGTTTGTAGA male infertile diseases 27958373 Identification and characterization of human testis derived circular RNAs and their existence in seminal plasma. Dong WW, Li HM, Qing XR, Huang DH, Li HG. Sci Rep. 2016 To validate these predicted circRNAs, 55 circRNAs of different abundance and lengths were randomly chosen for subsequent RT-PCR validation. Divergent primers were designed for circRNA detection. Among the 55 circRNAs, 30 of them could be specifically amplified. qRT-PCR human testis hsa_circ_0007292 circRNA homo sapiens ATP5C1 hsa_circ_0007292 TCACCAGGAGACTAAAGTCCATCAAAAACATCCAGAAAATTACCAAGTCTATGAAAATGGTAGCGGCAGCAAAATATGCCCGAGCTGAGAGAGAGCTGAAACCAGCTCGAATATATGGATTGGGATCTTTAGCTCTGTATGAAAAAGCTGATATCAAGGGGCCTGAAGACAAGAAGAAACACCTCCTTATTGGTGTGTCCTCAGATCGAGGACTGTGTGGTGCTATTCATTCCTCCATTGCTAAACAGATGAAAAGCGAGGTTGCTACACTAACAGCAGCTGGGAAAGAAGTTATGCTTGTTGGAATTGGTGACAAAATCAGAGGCATACTTTATAGGACTCATTCTGACCAGTTTCTGGTGGCATTCAAAGAAGTGGGAAGAAAGCCCCCCACTTTTGGAGATGCGTCAGTCATTGCCCTTGAATTACTAAATTCTGGATATGAATTTGATGAAGGCTCCATCATCTTTAATAAATTCAGGTCTGTCATCTCCTATAAGACAGAAGAAAAGCCCATCTTTTCCCTTAATACCGTTGCAAGTGCTGACAGCATGAGTATCTATGACGATATTGATGCTGACGTGCTGCAAAATTACCAAGAATACAATCTGGCCAACATCATCTACTACTCTCTGAAGGAGTCCACCACTAGTGAGCAGAGTGCCAGGATGACAGCCATGGACAATGCCAGCAAGAATGCTTCTGAGATGATTGACAAATTGACATTGACATTCAACCGTACCCGCCAAGCTGTCATCACAAAAGAGTTGATTGAAATTATCTCTGGTGCTGCAGCTCT 27373735 Screening and validation of lncRNAs and circRNAs as miRNA sponges. Militello G, Weirick T, John D, Döring C, Dimmeler S, Uchida S. Brief Bioinform. 2017 expressed in cytosol RT-PCR HEK293 hsa_circ_0007385 circRNA homo sapiens MEMO1 hsa_circ_0007385 CCATGCAGGATATACGTACTGTGGGTCTTGTGCTGCCCATGCTTATAAACAAGTGGATCCGTCTATTACCCGGAGAATTTTCATCCTTGGGCCTTCTCATCATGTGCCCCTCTCTCGATGTGCACTTTCCAGTGTGGATATATATAGGACACCTCTGTATGACCTTCGTATTGACCAAAAGATTTACGGAGAACTGTGGAAGACAGGAATGTTTGAACGCATGTCTCTGCAGACAGATGAAGATGAACACAGTATTGAAATGCATTTGCCTTATACAGCTAAAGCCATGGAAAG Non-small cell lung cancer 29372377 Microarray profiles reveal that circular RNA hsa_circ_0007385 functions as an oncogene in non-small cell lung cancer tumorigenesis. Jiang MM, Mai ZT, Wan SZ, Chi YM, Zhang X, Sun BH, Di QG. J Cancer Res Clin Oncol. 2018 hsa_circ_0007385 was significantly up regulated in NSCLC tissue and cells microarray, qRT-PCR NSCLC tissue and adjacent non-cancerous lung tissue, A549, SK-MES-1, H1299, and Calu-3 Hsa_circ_0007385 knockdown suppressed the proliferation of NSCLC cells in vitro. Hsa_circ_0007385 knockdown suppressed the migration, invasion of NSCLC cells in vitro. Hsa_circ_0007385 knockdown inhibited the tumor growth of NSCLC in vivo. loss of function H1299, A549 Athymic BALB/C mice (4¨C6-weeks-old) miR-181 circRNA-miRNA HEK293T luciferase reporter assay Luciferase reporter assay revealed the binding within miR-181 and hsa_circ_0007385. hsa_circ_0007534 circRNA homo sapiens DDX42 hsa_circ_0007534 CTATTTTGAAGATGAGGAAGAAGATTCTAGCAACGTTGATTTACCTTACATTCCTGCTGAAAACTCACCAACTCGCCAGCAATTCCATTCCAAGCCAGTAGATTCTGACAGCGATGATGATCCCTTGGAGGCATTCATGGCTGAAGTGGAGGATCAGGCAGCTAGAGACATGAAGAGGCTTGAAGAAAAGGACAAGGAAAGAAAAAACGTAAAGGGTATTCGAGATGACATTGAAGAGGAAGATGACCAAGAAGCTTATTTTCGATACATGGCAGAAAACCCAACTGCTGGTGTGGTTCAGGAGGAAGAGGAAGACAATCTAGAATATGATAGTGACGGAAATCCAATTGCACCTACCAAAAAAATCATTGATCCTCTTCCCCCCATTGATCATTCAGAG breast cancer 29593432 Downregulation of hsa_circ_0011946 suppresses the migration and invasion of the breast cancer cell line MCF-7 by targeting RFC3. Zhou J, Zhang WW, Peng F, Sun JY, He ZY, Wu SG. Cancer Manag Res. 2018 up-regulated in both cells and breast cancer tissues RNA-seq, qRT-PCR breast cancer and corresponding adjacent non-cancerous tissues, HS-578T, T47D, MCF-7, BT549, MDA-MB-231, and SKBR-5 hsa_circ_0007534 circRNA homo sapiens DDX42 hsa_circ_0007534 CTATTTTGAAGATGAGGAAGAAGATTCTAGCAACGTTGATTTACCTTACATTCCTGCTGAAAACTCACCAACTCGCCAGCAATTCCATTCCAAGCCAGTAGATTCTGACAGCGATGATGATCCCTTGGAGGCATTCATGGCTGAAGTGGAGGATCAGGCAGCTAGAGACATGAAGAGGCTTGAAGAAAAGGACAAGGAAAGAAAAAACGTAAAGGGTATTCGAGATGACATTGAAGAGGAAGATGACCAAGAAGCTTATTTTCGATACATGGCAGAAAACCCAACTGCTGGTGTGGTTCAGGAGGAAGAGGAAGACAATCTAGAATATGATAGTGACGGAAATCCAATTGCACCTACCAAAAAAATCATTGATCCTCTTCCCCCCATTGATCATTCAGAG colorectal cancer 29364478 Silencing of hsa_circ_0007534 suppresses proliferation and induces apoptosis in colorectal cancer cells. Zhang R, Xu J, Zhao J, Wang X. Eur Rev Med Pharmacol Sci. 2018 up microarray, qRT-PCR FHC, SW620, HCT116, LoVo, SW480, and HT29, pairs of CRC tumor tissues and matched adjacent non-tumorous tissues Silencing of hsa_circ_0007534 Suppresses Proliferation and Induces Apoptosis in CRC Cell Lines loss of function SW620, LoVo circRNA CREBBP circRNA homo sapiens CREBBP hsa_circ_0007637 ATTTTGGATCATTGTTTGACTTGGAAAATGATCTTCCTGATGAGCTGATACCCAATGGAGGAGAATTAGGCCTTTTAAACAGTGGGAACCTTGTTCCAGATGCTGCTTCCAAACATAAACAACTGTCGGAGCTTCTACGAGGAGGCAGCGGCTCTAGTATCAACCCAGGAATAGGAAATGTGAGCGCCAGCAGCCCCGTGCAGCAGGGCCTGGGTGGCCAGGCTCAAGGGCAGCCGAACAGTGCTAACATGGCCAGCCTCAGTGCCATGGGCAAGAGCCCTCTGAGCCAGGGAGATTCTTCAGCCCCCAGCCTGCCTAAACAGGCAGCCAGCACCTCTGGGCCCACCCCCGCTGCCTCCCAAGCACTGAATCCGCAAGCACAAAAGCAAGTGGGGCTGGCGACTAGCAGCCCTGCCACGTCACAGACTGGACCTGGTATCTGCATGAATGCTAACTTTAACCAGACCCACCCAGGCCTCCTCAATAGTAACTCTGGCCATAGCTTAATTAATCAGGCTTCACAAGGGCAGGCGCAAGTCATGAATGGATCTCTTGGGGCTGCTGGCAGAGGAAGGGGAGCTGGAATGCCGTACCCTACTCCAGCCATGCAGGGCGCCTCGAGCAGCGTGCTGGCTGAGACCCTAACGCAGGTTTCCCCGCAAATGACTGGTCACGCGGGACTGAACACCGCACAGGCAGGAGGCATGGCCAAG 25558066 Analysis of intron sequences reveals hallmarks of circular RNA biogenesis in animals. Ivanov A, Memczak S, Wyler E, Torti F, Porath HT, Orejuela MR, Piechotta M, Levanon EY, Landthaler M, Dieterich C, Rajewsky N. Cell Rep. 2015 This circRNA with top H score and high/medium expression of the host transcript was (1) resistant to RNase R and (2) had the predicted head-to-tail junctions, as validated by Sanger sequencing, suggesting that the circRNA exists in circularized form in HEK293 cells. qRT-PCR, sanger sequencing HEK293 cells hsa_circ_0007637 circRNA homo sapiens CREBBP hsa_circ_0007637 ATTTTGGATCATTGTTTGACTTGGAAAATGATCTTCCTGATGAGCTGATACCCAATGGAGGAGAATTAGGCCTTTTAAACAGTGGGAACCTTGTTCCAGATGCTGCTTCCAAACATAAACAACTGTCGGAGCTTCTACGAGGAGGCAGCGGCTCTAGTATCAACCCAGGAATAGGAAATGTGAGCGCCAGCAGCCCCGTGCAGCAGGGCCTGGGTGGCCAGGCTCAAGGGCAGCCGAACAGTGCTAACATGGCCAGCCTCAGTGCCATGGGCAAGAGCCCTCTGAGCCAGGGAGATTCTTCAGCCCCCAGCCTGCCTAAACAGGCAGCCAGCACCTCTGGGCCCACCCCCGCTGCCTCCCAAGCACTGAATCCGCAAGCACAAAAGCAAGTGGGGCTGGCGACTAGCAGCCCTGCCACGTCACAGACTGGACCTGGTATCTGCATGAATGCTAACTTTAACCAGACCCACCCAGGCCTCCTCAATAGTAACTCTGGCCATAGCTTAATTAATCAGGCTTCACAAGGGCAGGCGCAAGTCATGAATGGATCTCTTGGGGCTGCTGGCAGAGGAAGGGGAGCTGGAATGCCGTACCCTACTCCAGCCATGCAGGGCGCCTCGAGCAGCGTGCTGGCTGAGACCCTAACGCAGGTTTCCCCGCAAATGACTGGTCACGCGGGACTGAACACCGCACAGGCAGGAGGCATGGCCAAG male infertile diseases 27958373 Identification and characterization of human testis derived circular RNAs and their existence in seminal plasma. Dong WW, Li HM, Qing XR, Huang DH, Li HG. Sci Rep. 2016 To validate these predicted circRNAs, 55 circRNAs of different abundance and lengths were randomly chosen for subsequent RT-PCR validation. Divergent primers were designed for circRNA detection. Among the 55 circRNAs, 30 of them could be specifically amplified. qRT-PCR human testis circMTO1 circRNA homo sapiens MTO1 hsa_circ_0007874 hsa_circRNA_104135 GTCAGATGTCATGTAATCCTTCCTTTGGTGGCATCGGAAAGGGACATTTAATGAGGGAAGTAGATGCCTTGGATGGCCTGTGTTCTCGCATCTGTGACCAGTCTGGTGTACATTATAAAGTATTAAACCGGCGTAAGGGACCAGCTGTGTGGGGTCTGAGAGCTCAGATTGATAGGAAACTCTATAAACAGAACATGCAGAAAGAAATCTTGAATACACCACTGCTTACTGTTCAGGAGGGAGCTGTAGAAGATCTTATTCTTACAGAACCAGAGCCTGAACACACTGGGAAATGCCGTGTCAGTGGGGTTGTTTTGG Hepatocellular Carcinoma 28520103 Circular RNA circMTO1 acts as the sponge of microRNA-9 to suppress hepatocellular carcinoma progression. Han D, Li J, Wang H, Su X, Hou J, Gu Y, Qian C, Lin Y, Liu X, Huang M, Li N, Zhou W, Yu Y, Cao X. Hepatology. 2017 circMTO1 expression was consistently and significantly decreased in HCC tumor tissues as compared to that in matched nontumor liver tissues.Decreased circMTO1 expression is significantly correlated with poor prognosis of HCC patients. microarray, qRT-PCR hepatocellular carcinoma tumor tissues, nontumor liver tissues circMTO1 suppresses HCC progression by acting as the sponge of oncogenic miR-9 to promote p21 expression, suggesting that circMTO1 is a potential target in HCC treatment. The decrease of circMTO1 in HCC tissues may serve as a prognosis predictor for poor survival of patients. HepG2, SMMC-7721, QGY-7701, SK-Hep1 HCC-bearing male nude mice model SMMCLTNM HCC and paired adjacent liver tissues miR-9 circRNA-miRNA HepG2 cells RNA pull-down circMTO1 can bind miR-9 in the cytoplasm. p21 hsa_circRNA_104595 circRNA homo sapiens FGFR1 hsa_circ_0008016 CCCAGCCCTGGGGAGCCCCTGTGGAAGTGGAGTCCTTCCTGGTCCACCCCGGTGACCTGCTGCAGCTTCGCTGTCGGCTGCGGGACGATGTGCAGAGCATCAACTGGCTGCGGGACGGGGTGCAGCTGGCGGAAAGCAACCGCACCCGCATCACAGGGGAGGAGGTGGAGGTGCAGGACTCCGTGCCCGCAGACTCCGGCCTCTATGCTTGCGTAACCAGCAGCCCCTCGGGCAGTGACACCACCTACTTCTCCGTCAATGTTTCAG papillary thyroid carcinoma 28288173 Microarray profiling of circular RNAs in human papillary thyroid carcinoma. Peng N, Shi L, Zhang Q, Hu Y, Wang N, Ye H. PLoS One. 2017 upregulated microarray, qRT-PCR PTC tumors, matching contralateral normal samples, benign thyroid lesions (i.e., follicular adenoma samples and multinodular goiter samples) hsa-miR-412-3p, hsa-miR-363-5p, hsa-miR-608, hsa-miR-564, hsa-miR-196b-3p circRNA-miRNA predicted circPDE4B circRNA homo sapiens PDE4B hsa_circ_0008433 GTATTAAAAAGTGTCAGCAAACTGCATTGAATAACAGACATCCTAAGAGGGGATATTTTCCACCTCTATAATGAAGAAAAGCAGGAGTGTGATGACGGTGATGGCTGATGATAATGTTAAAGATTATTTTGAATGTAGCTTGAGTAAATCCTACAGTTCTTCCAGTAACACACTTGGGATCGACCTCTGGAGAGGGAGAAGGTGTTGCTCAGGAAACTTACAGTTACCACCACTGTCTCAAAGACAGAGTGAAAGGGCAAGGACTCCTGAGGGAGATGGTATTTCCAGGCCGACCACACTGCCTTTGACAACGCTTCCAAGCATTGCTATTACAACTGTAAGCCAGGAGTG Lupus Nephritis 29499937 circHLA-C Plays an Important Role in Lupus Nephritis by Sponging miR-150. Luan J, Jiao C, Kong W, Fu J, Qu W, Chen Y, Zhu X, Zeng Y, Guo G, Qi H, Yao L, Pi J, Wang L, Zhou H. Mol Ther Nucleic Acids. 2018 Significantly upregulated in LN renal biopsies compared with NC kidneys RNA-seq, qRT-PCR lupus nephritis renal biopsies and negtive control kidneys hsa_circ_0008496 circRNA homo sapiens PABPC1 hsa_circ_0008496 GGCCTGCCTTAAGTGTGAAAGTAATGACTGATGAAAGTGGAAAATCCAAAGGATTTGGATTTGTAAGCTTTGAAAGGCATGAAGATGCACAGAAAGCTGTGGATGAGATGAACGGAAAGGAGCTCAATGGAAAACAAATTTATGTTGGTCGAGCTCAGAAAAAGGTGGAACGGCAGACGGAACTTAAGCGCAAATTTGAACAGATGAAACAAGATAGGATCACCAGATACCAGGGTGTTAATCTTTATGTGAAAAATCTTGATGATGGTATTGATGATGAACGTCTCCGGAAAGAGTTTTCTCCATTTGGTACAATCACTAGTGCAAAGGTTATGATGGAGGGTGGTCGCAGCAAAGGGTTTGGTTTTGTATGTTTCTCCTCCCCAGAAGAAGCCACTAAAGCAGTTACAGAAATGAACGGTAGAATTGTGGCCACAAAGCCATTGTATGTAGCTTTAGCTCAGCGCAAAGAAGAGCGCCAGGCTCACCTCACTAACCAGTATATGCAGAGAATGGCAAGTGTACGAGCTGTTCCCAACCCTGTAATCAACCCCTACCAGCCAGCACCTCCTTCAGGTTACTTCATGGCAGCTATCCCACAGACTCAGAACCGTGCTGCATACTATCCTCCTAGCCAAATTGCTCAACTAAGACCAAGTCCTCGCTGGACTGCTCAGGGTGCCAGACCTCATC hepatocellular carcinoma 29144509 Circular RNA expression is suppressed by androgen receptor (AR)-regulated adenosine deaminase that acts on RNA (ADAR1) in human hepatocellular carcinoma. Shi L, Yan P, Liang Y, Sun Y, Shen J, Zhou S, Lin H, Liang X, Cai X. Cell Death Dis. 2017 upregulated more than fivefold as revealed by circRNA microarray after AR knocking down in MHCC-97h cells microarray, qRT-PCR MHCC-97h, LM3 and LO3 cells hsa_circ_0008509 circRNA homo sapiens NAV3 hsa_circ_0008509 ATTTACACTGACTGGGCCAACCACTACCTAGCAAAATCAGGCCACAAGCGGCTGATCAAGGACTTGCAACAAGACATTGCAGATGGAGTACTCCTAGCAGAAATCATCCAGATTATTGCAAATGAAAAAGTTGAAGATATCAATGGATGTCCTAGAAGTCAGTCTCAGATGATTGAAAATGTTGATGTCTGCCTTAGTTTTCTAGCAGCCAGAGGGGTAAATGTTCAAGGTCTATCTGCTGAAGAAATAAGAAATGGAAACTTAAAAGCCATTCTAGGGCTGTTTTTCAGTTTATCTCGCTACAAGCAGCAACAACACCATCAACAACAGTACTATCAGTCCTTGGTGGAACTTCAGCAGCGAGTTACTCACGCTTCCCCTCCATCGGAAGCCAGCCAGGCCAAAACCCAGCAAGATATGCAGTCCAGTCTGGCAGCCAGATATGCAACTCAGTCTAATCACAGTGGAATTGCAACCAGTCAAAAAAAGCCTACTAGGCTTCCAGGGCCCTCTAGGGTGCCTGCTGCAGGAAGCAGCAGCAAGGTCCAGGGAGCCTCTAATTTAAATAGGAGAAGTCAGAGCTTTAACAGCATTGACAAAAACAAGCCTCCAAATTATGCAAATGGAAACGAAAAAGATTCCTCCAAAGGACCTCAATCGTCTTCAGGTGTAAATGGTAACGTGCAGCCTCCCAGTACTGCTGGGCAGCCTCCTGCCTCTGCCATCCCTTCTCCAAGTGCCAGCAAGCCCTGGCGCAGCAAGTCCATGAATGTCAAACACAGTGCCACCTCCACCATGTTGACTGTAAAGCAGTCAAGTACAGCCACCTCCCCCACACCATCTTCAGACAGACTGAAGCCACCTGTCTCAGAAGGGGTCAAAACTGCTCCCTCAGGACAGAAATCCATGCTTGAGAAATTCAAGCTAGTCAATGCCCGGACTGCTTTACGCCCCCCGCAGCCTCCCAGTTCAGGACCTAGTGATGGTGGGAAGGATGATGATGCCTTTTCTGAATCTGGTGAAATGGAAGGTTTTAACAGTGGTCTGAATAGTGGTGGCTCAACAAATAGCAGTCCCAAAGTGTCACCTAAGTTGGCCCCTCCAAAAGCTGGAAGCAAAAATCTCAGCAATAAAAAGTCTTTGCTACAGCCAAAGGAAAAAGAAGAAAAGAACAGGGACAAAAATAAAGTTTGCACTGAAAAACCAGTCAAAGAAGAGAAGGATCAGGTGACAGAGATGGCTCCAAAAAAGACCTCCAAAATTGCAAGCTTGATCCCTAAGGGCAGCAAGACAACAGCAGCTAAGAAGGAAAGCTTAATTCCGTCTTCCAGTGGTATTCCAAAACCAGGCTCTAAAGTTCCAACAGTAAAGCAAACCATTTCACCTGGCAGCACAGCAAGCAAAGAGTCTGAGAAATTCAGGACTACCAAGGGGAGCCCTTCCCAGTCCTTATCTAAGCCTATAACCATGGAGAAAGCAAGTGCTTCTAGTTGTCCTGCCCCTTTGGAAGGAAGGGAAGCTGGCCAAGCTTCTCCTTCTGGTTCCTGTACCATGACAGTGGCACAAAGCAGTGGGCAGAGCACAGGAAATGGTGCTGTCCAACTCCCTCAACAGCAGCAACATAGCCACCCGAATACCGCGACAGTGGCACCATTCATTTACAGGGCACATTCAGAAAATGAAGGTACCGCTTTACCATCGGCTGACTCCTGTACCAGTCCTACAAAGATGGACTTATCATATAGTAAGACTGCTAAGCAGTGCCTGGAGGAGATATCTG Colorectal cancer 28656150 Microarray Analysis of Circular RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells. Xiong W, Ai YQ, Li YF, Ye Q, Chen ZT, Qin JY, Liu QY, Wang H, Ju YH, Li WH, Li YF. Biomed Res Int. 2017 down microarray, qRT-PCR CRR (chemoradiation resistance)-HCT116 and the parental HCT116 cells cANRIL circRNA homo sapiens CDKN2B-AS hsa_circ_0008574 TGTCCCTTTTGATGAGAAGAATAAGCCTCATTCTGATTCAACAGCAGAGATCAAAGAAAAGACTTCTGTTTTCTGGCCACCAGATATATGTTATCTGTGCTTAAAGAATTGAAAAACACACATCAAAGGAGAATTTTCTTGGAAAGAGAGGGTTCAAGCATCACTGTTAGGTGTGCTGGAATCCTTTCCCGAGTCAGTACTGCTTTCTAGAAGAAAACCGGGGAGATCTATTTGGAATGTATCTAACTCCAAAGAAACCATCAGAGGTAACAGTAGAGACGGGGTTTCACCATGTTGGCCAGACTGGTCTTGAACTCTCGACCTCGTGATTCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGACACCACACCCGGCGGATAGAGAGAATTTTGACAG Coronary Atherosclerosis 28683453 Effect of Circular ANRIL on the Inflammatory Response of Vascular Endothelial Cells in a Rat Model of Coronary Atherosclerosis. Song CL, Wang JP, Xue X, Liu N, Zhang XH, Zhao Z, Liu JG, Zhang CP, Piao ZH, Liu Y, Yang YB. Cell Physiol Biochem. 2017 Our study provides evidence that reduced cANRIL expression could prevent coronary AS by reducing vascular EC apoptosis and inflammatory factor expression. loss of function, gain of function Rat Model of Coronary Atherosclerosis circ-ABCB10 circRNA homo sapiens ABCB10 hsa_circ_0008717 TTTTTTGTCTCACCTAATCTGGCCACCTTTGTTTTGAGCGTGGTGCCTCCAGTGTCAATCATTGCTGTAATTTATGGGCGATATCTACGGAAACTGACCAAAGTCACTCAGGATTCCCTGGCACAAGCCACTCAGCTAGCTGAGGAACGTATTGGAAATGTAAGAACTGTTCGAGCTTTTGGGAAAGAAATGACTGAAATCGAGAAATATGCCAGCAAAGTGGACCATGTAATGCAGTTAGCAAGGAAAGAGGCATTCGCCCGGGCTGGTTTCTTTGGAGCAACTGGGCTCTCCGGAAACCTGATCGTGCTTTCTGTCCTGTACAAAGGAGGGCTGCTGATGGGCAGTGCCCACATGACCGTGGGTGAACTCTCTTCCTTCCTAATGTATGCTTTCTGGGTTGGAATAAGCATTGGAGGTCTGAGCTCTTTCTACTCGGAGCTGATGAAAGGACTGGGTGCAGGGGGGCGCCTCTGGGAGCTCCTGGAGAGAGAGCCCAAGCTGCCTTTTAACGAGGGGGTCATCTTAAATGAGAAAAGCTTCCAGGGTGCTTTGGAGTTTAAGAACGTGCATTTTGCCTATCCAGCTCGCCCAGAGGTGCCCATATTTCAGGATTTCAGCCTTTCCATTCCGTCAGGATCTGTCACGGCACTGGTTGGCCCAAGTGGTTCTGGCAAATCAACAGTGCTTTCACTCCTGCTGAGGTTGTACGACCCTGCTTCTG breast cancer 28744405 Circular RNA circ-ABCB10 promotes breast cancer proliferation and progression through sponging miR-1271. Liang HF, Zhang XZ, Liu BG, Jia GT, Li WL. Am J Cancer Res. 2017 circ-ABCB10 was identified to be significantly up-regulated in breast cancer microarray, qRT-PCR cancer and adjacent noncancerous tissue. MCF-7, MDAMB-231, MDA-MB-468, MDA-MB-453, MCF-10A Circ-ABCB10 knockdown suppressed breast cancer cells proliferation and enhanced apoptosis. loss of function MCF-7, MDA-MB-231 miR-1271 circRNA-miRNA HEK293T luciferase reporter assay Luciferase reporter assay showed the luciferase intensity of miR-1271 binding with circ-ABCB10 wild type was decreased. hsa_circ_0008719 circRNA homo sapiens AKT2 hsa_circ_0008719 ACTGTGCCCTGTCCACGGTGCCTCCTGCATGTCCTGCTGCCCTGAGCTGTCCCGAGCTAGGTGACAGCGTACCACGCTGCCACCATGAATGAGGTGTCTGTCATCAAAGAAGGCTGGCTCCACAAGCGTGGTGAATACATCAAGACCTGGAGGCCACGGTACTTCCTGCTGAAGAGCGACGGCTCCTTCATTGGGTACAAGGAGAGGCCCGAGGCCCCTGATCAGACTCTACCCCCCTTAAACAACTTCTCCGTAGCAGAATGCCAGCTGATGAAGACCGAGAGGCCGCGACCCAACACCTTTGTCATACGCTGCCTGCAGTGGACCACAGTCATCGAGAGGACCTTCCACGTGGATTCTCCAGACGAGAG pancreatic ductal adenocarcinoma 27997903 Circular RNA Expression Profile of Pancreatic Ductal Adenocarcinoma Revealed by Microarray. Li H, Hao X, Wang H, Liu Z, He Y, Pu M, Zhang H, Yu H, Duan J, Qu S. Cell Physiol Biochem. 2016 down microarray, qRT-PCR PDAC samples and corresponding normal tissues hsa_circ_0008732 circRNA homo sapiens BNC2 hsa_circ_0008732 GCACACCTTGGGCCCACCCCACCTCCACATAGCCTTAATTACAAATCAGAGGACAGGCTTAGTGAGCAAGACTGGCCAGCATATTTCAAGGTCCCATGTTGTGGGGTTGATACATCTCAAATTGAGTCAGAAGAGGCAGAAGTGGATGTGAGAGAAAGAGAGACACAGAGAGACAGAGAGCCAAAGAGGGCAAGAGACTTGACTTTAAGAGACTCCTGTACTGACAACTCCATGCAGTTCGGAACCAGAACGACTACGGCTGAACCAGGGTTCATGGGGACATGGCAAAACGCTGATACTAACCTCTTATTCAGAATGTCCCAACAG basal cell carcinoma 27097056 Circular RNA expression in basal cell carcinoma. Sand M, Bechara FG, Sand D, Gambichler T, Hahn SA, Bromba M, Stockfleth E, Hessam S. Epigenomics. 2016 up microarray, qRT-PCR, FISH nodular BCC and nonlesional skin tissues hsa_circ_0008797 circRNA homo sapiens GSK3B hsa_circ_0008797 ATGTATGGTCTGCTGGCTGTGTGTTGGCTGAGCTGTTACTAGGACAACCAATATTTCCAGGGGATAGTGGTGTGGATCAGTTGGTAGAAATAATCAAGGTCCTGGGAACTCCAACAAGGGAGCAAATCAGAGAAATGAACCCAAACTACACAGAATTTAAATTCCCTCAAATTAAGGCACATCCTTGGACTAAGGATTCGTCAGGAACAGGACATTTCACCTCAGGAGTGCGGGTCTTCCGACCCCGAACTCCACCGGAGGCAATTGCACTGTGTAGCCGTCTGCTGGAGTATACACCAACTGCCCGACTAACACCACTGGAAGCTTGTGCACATTCATTTTTTGATGAATTACGGGACCCAAATGTCAAACTACCAAATGGGCGAGACACACCTGCACTCTTCAACTTCACCACTCAAG Active Pulmonary Tuberculosis 29248507 Potential Diagnostic Power of Blood Circular RNA Expression in Active Pulmonary Tuberculosis. Qian Z, Liu H, Li M, Shi J, Li N, Zhang Y, Zhang X, Lv J, Xie X, Bai Y, Ge Q, Ko EA, Tang H, Wang T, Wang X, Wang Z, Zhou T, Gu W. EBioMedicine. 2018 Upregulated in TB patients compared to healthy controls. RNA-seq, microarray, qRT-PCR healthy controls and TB patients hsa_circ_0008887 circRNA homo sapiens HIPK3 hsa_circ_0008887 GTATGGCCTCACAAGTCTTGGTCTACCCACCATATGTTTATCAAACTCAGTCAAGTGCCTTTTGTAGTGTGAAGAAACTCAAAGTAGAGCCAAGCAGTTGTGTATTCCAGGAAAGAAACTATCCACGGACCTATGTGAATGGTAGAAACTTTGGAAATTCTCATCCTCCCACTAAGGGTAGTGCTTTTCAGACAAAGATACCATTTAATAGACCTCGAGGACACAACTTTTCATTGCAGACAAGTGCTGTTGTTTTGAAAAACACTGCAGGTGCTACAAAGGTCATAGCAGCTCAGGCACAGCAAGCTCACGTGCAGGCACCTCAGATTGGGGCGTGGCGAAACAGATTGCATTTCCTAGAAGGCCCCCAGCGATGTGGATTGAAGCGCAAGAGTGAGGAGTTGGATAATCATAGCAGCGCAATGCAGATTGTCGATGAATTGTCCATACTTCCTGCAATGTTGCAAACCAACATGGGAAATCCAGTGACAGTTGTGACAGCTACCACAGGATCAAAACAGAATTGTACCACTGGAGAAGGTGACTATCAGTTAGTACAGCATGAAGTCTTATGCTCCATGAAAAATACTTACGAAGTCCTTGATTTTCTTGGTCGAGGCACGTTTGGCCAGGTAGTTAAATGCTGGAAAAGAGGGACAAATGAAATTGTAGCAATCAAAATTTTGAAGAATCATCCTTCTTATGCCCGTCAAGGTCAAATAGAAGTGAGCATATTAGCAAGGCTCAGTACTGAAAATGCTGATGAATATAACTTTGTACGAGCTTATGAATGCTTTCAGCACCGTAACCATACTTGTTTAGTCTTTGAGATGCTGGAACAAAACTTGTATGACTTTCTGAAACAAAATAAATTTAGTCCCCTGCCACTAAAAGTGATTCGGCCCATTCTTCAACAAGTGGCCACTGCACTGAAAAAATTGAAAAGTCTTGGTTTAATTCATGCTGATCTCAAGCCAGAGAATATTATGTTGGTGGATCCTGTTCGGCAGCCTTACAGGGTTAAAGTAATAGACTTTGGGTCGGCCAGTCATGTATCAAAGACTGTTTGTTCAACATATCTACAATCTCGGTACTACAGAGCTCCAGAGATTATATTGGGGTTGCCATTTTGTGAAGCCATAGACATGTGGTCATTGGGATGTGTGATTGCAGAATTATTTCTTGGATGGCCGCTCTACCCAGGAGCCTTGGAGTATGATCAG 27373735 Screening and validation of lncRNAs and circRNAs as miRNA sponges. Militello G, Weirick T, John D, Döring C, Dimmeler S, Uchida S. Brief Bioinform. 2017 expressed in cytosol RT-PCR HEK293 circMATR3 circRNA homo sapiens MATR3 hsa_circ_0008922 GATGACTTGAAAGTAGGGCATCCTTCACCCATCTGAAGGGAGGAAATAGTGGCAGGTGACAGTCTGCATGTGCAGTTTTCAGATGCCTTCACCTGAATGACATCTACCTCCATCAGGACCCCAGATGTCTGACAGCCCTGTGTGACACCAAGATAAGTAAC 28444238 High-purity circular RNA isolation method (RPAD) reveals vast collection of intronic circRNAs. Panda AC, De S, Grammatikakis I, Munk R, Yang X, Piao Y, Dudekula DB, Abdelmohsen K, Gorospe M. Nucleic Acids Res. 2017 circRNA junctions were indeed amplified and verifying the presence of backsplice sites in these transcripts. qRT-PCR HeLa hsa_circ_0008945 circRNA homo sapiens NIN hsa_circ_0008945 CTGCACAGATGTCCCGATCTCTCTGACTTCCAGCAAAAAATCTCTAGTGTTCTAAGCTACAACGAAAAACTGCTGAAAGAAAAGGAAGCTCTGAGTGAGGAATTAAATAGCTGTGTCGATAAGTTGGCAAAATCAAGTCTTTTAGAGCATAGAATTGCGACGATGAAGCAGGAACAGAAATCCTGGGAACATCAGAGTGCGAGCTTAAAGTCACAGCTGGTGGCTTCTCAGGAAAAGGTTCAGAATTTAGAAGACACCGTGCAGAATGTAAACCTGCAAATGTCCCGGATGAAATCTGACCTACGAGTGACTCAGCAGGAAAAGGAGGCTTTAAAACAAGAAGTGATGTCTTTACATAAGCAACTTCAGAATGCTGGTGGCAAG breast cancer 28744405 Circular RNA circ-ABCB10 promotes breast cancer proliferation and progression through sponging miR-1271. Liang HF, Zhang XZ, Liu BG, Jia GT, Li WL. Am J Cancer Res. 2017 up-regulated in breast cancer microarray, qRT-PCR cancer and adjacent noncancerous tissue hsa_circ_0009128 circRNA homo sapiens TXNDC11 hsa_circ_0009128 TCGAGCAAAAGATGTGATAATACCAGCAAAGCCACCTGTCAGCTTTTTCTCCTTGAGGTCTCCAGTCCTTGACCTCTTCCAGGGGCAGCTGGATTATGCAGAGTACGTTCGACGGGATTCAGAGGTGGTACTGCTCTTCTTCTATGCCCCTTGGTGTGGACAGTCCATCGCTGCCAGGGCAGAAATTGAGCAAGCAGCAAGTCGGCTTTCAGATCAGGTGTTGTTTGTGGCAATTAACTGTTGGTGGAACCAGGGGAAATGCAGAAAACAGAAACACTTCTTTTATTTTCCTGTAATATATCTGTATCATCGGAGTTTTGGACCAATCGAATACAAAGGCCCCATGAGTGCTGTTTACATTGAGAAGTTTGTCCGCCGGGTGATGAAACCACTTCTCTACATCCCATCTCAATCAGAATTACTAGATTTTCTCTCAAACTACGAGCCTGGAGTACTCGGGTACTTTGAGTTCAGTGGCTCACCCCAGCCTCCTGGTTATTTGACCTTCTTCACCTCAGCATTACATTCATTAAAGAAAG Active Pulmonary Tuberculosis 28846924 The circular RNA of peripheral blood mononuclear cells: Hsa_circ_0005836 as a new diagnostic biomarker and therapeutic target of active pulmonary tuberculosis. Zhuang ZG, Zhang JA, Luo HL, Liu GB, Lu YB, Ge NH, Zheng BY, Li RX, Chen C, Wang X, Liu YQ, Liu FH, Zhou Y, Cai XZ, Chen ZW, Xu JF. Mol Immunol. 2017 significantly decreased in APTB patients compared to HC patients. RNA-seq, qRT-PCR APTB patients, HC patients. hsa_circ_0009222 circRNA homo sapiens AGRN hsa_circ_0009222 ACCAGTGCCCGGAGCCCTGCCGGTTCAATGCCGTGTGCCTGTCCCGCCGTGGCCGTCCCCGCTGCTCCTGCGACCGCGTCACCTGTGACGGGGCCTACAGGCCCGTGTGTGCCCAGGACGGGCGCACGTATGACAGTGATTGCTGGCGGCAGCAGGCTGAGTGCCGGCAGCAGCGTGCCATCCCCAGCAAGCACCAGGGCCCGTGTGACCAGGCCCCGTCCCCATGCCTCGGGGTGCAGTGTGCATTTGGGGCGACGTGTGCTGTGAAGAACGGGCAGGCAGCGTGTGAATGCCTGCAGGCGTGCTCGAGCCTCTACGATCCTGTGTGCGGCAGCGACGGCGTCACATACGGCAGCGCGTGCGAGCTGGAGGCCACGGCCTGTACCCTCGGGCGGGAGATCCAGGTGGCGCGCAAAGGACCCTGTGACCGCTGCGGGCAGTGCCGCTTTGGAGCCCTGTGCGAGGCCGAGACCGGGCGCTGCGTGTGCCCCTCTGAATGCGTGGCTTTGGCCCAGCCCGTGTGTGGCTCCGACGGGCACACGTACCCCAGCGAGTGCATGCTGCACGTGCACGCCTGCACACACCAGATCAGCCTGCACGTGGCCTCAGCTGGACCCTGTGAGACCTGTGGAGATGCCGTGTGTGCTTTTGGGGCTGTGTGCTCCGCAGGGCAGTGTGTGTGTCCCCGGTGTGAGCACCCCCCGCCCGGCCCCGTGTGTGGCAGCGACGGTGTCACCTACGGCAGTGCCTGCGAGCTACGGGAAGCCGCCTGCCTCCAGCAGACACAGATCGAGGAGGCCCGGGCAGGGCCGTGCGAGCAGGCCGAGTGCGGTTCCGGAGGCTCTGGCTCTGGGGAGGACGGTGACTGTGAGCAGGAGCTGTGCCGGCAGCGCGGTGGCATCTGGGACGAGGACTCGGAGGACGGGCCGTGTGTCTGTGACTTCAGCTGCCAGAGTGTCCCAGGCAGCCCGGTGTGCGGCTCAGATGGGGTCACCTACAGCACCGAGTGTGAGCTGAAGAAGGCCAGGTGTGAGTCACAGCGAGGGCTCTACGTAGCGGCCCAGGGAGCCTGCCGAGGCCCCACCTTCGCCCCGCTGCCGCCTGTGGCCCCCTTACACTGTGCCCAGACGCCCTACGGCTGCTGCCAGGACAATATCACCGCAGCCCGGGGCGTGGGCCTGGCTGGCTGCCCCAGTGCCTGCCAGTGCAACCCCCATGGCTCTTACGGCGGCACCTGTGACCCAGCCACAGGCCAGTGCTCCTGCCGCCCAGGTGTGGGGGGCCTCAGGTGTGACCGCTGTGAGCCTGGCTTCTGGAACTTTCGAGGCATCGTCACCGATGGCCGGAGTGGCTGTACACCCTGCAGCTGTGATCCCCAAGGCGCCGTGCGGGATGACTGTGAGCAGATGACGGGGCTGTGCTCGTGTAAGCCCGGGGTGGCTGGACCCAAGTGTGGGCAGTGTCCAGACGGCCGTGCCCTGGGCCCCGCGGGCTGTGAAGCTGACGCTTCTGCGCCTGCGACCTGTGCGGAGATGCGCTGTGAGTTCGGTGCGCGGTGCGTGGAGGAGTCTGGCTCAGCCCACTGTGTCTGCCCGATGCTCACCTGTCCAGAGGCCAACGCTACCAAGGTCTGTGGGTCAGATGGAGTCACATACGGCAACGAGTGTCAGCTGAAGACCATCGCCTGCCGCCAGGGCCTGCAAATCTCTATCCAGAGCCTGGGCCCGTGCCAGGAGGCTGTTGCTCCCAGCACTCACCCGACATCTGCCTCCGTGACTGTGACCACCCCAGGGCTCCTCCTGAGCCAGGCACTGCCGGCCCCCCCCGGCGCCCTCCCCCTGGCTCCCAGCAGTACCGCACACAGCCAGACCACCCCTCCGCCCTCATCACGACCTCGGACCACTGCCAGCGTCCCCAGGACCACCGTGTGGCCCGTGCTGACGGTGCCCCCCACGGCACCCTCCCCTGCACCCAGCCTGGTGGCGTCCGCCTTTGGTGAATCTGGCAGCACTGATGGAAGCAGCGATGAGGAACTGAGCGGGGACCAGGAGGCCAGTGGGGGTGGCTCTGGGGGGCTCGAGCCCTTGGAGGGCAGCAGCGTGGCCACCCCTGGGCCACCTGTCGAGAGGGCTTCCTGCTACAACTCCGCGTTGGGCTGCTGCTCTGATGGGAAGACGCCCTCGCTGGACGCAGAGGGCTCCAACTGCCCCGCCACCAAGGTGTTCCAGGGCGTCCTGGAGCTGGAGGGCGTCGAGGGCCAGGAGCTGTTCTACACGCCCGAGATGGCTGACCCCAAGTCAGAACTGTTCGGGGAGACAGCCAGGAGCATTGAGAGCACCCTGGACGACCTCTTCCGGAATTCAGACGTCAAGAAGGATTTTCGGAGTGTCCGCTTGCGGGACCTGGGGCCCGGCAAATCCGTCCGCGCCATTGTGGATGTGCACTTTGACCCCACCACAGCCTTCAGGGCACCCGACGTGGCCCGGGCCCTGCTCCGGCAGATCCAGGTGTCCAGGCGCCGGTCCTTGGGGGTGAGGCGGCCGCTGCAGGAGCACGTGCGATTTATGGACTTTGACTGGTTTCCTGCGTTTATCACGGGGGCCACGTCAGGAGCCATTGCTGCGGGAGCCACGGCCAGAGCCACCACTGCATCGCGCCTGCCGTCCTCTGCTGTGACCCCTCGGGCCCCGCACCCCAGTCACACAAGCCAGCCCGTTGCCAAGACCACGGCAGCCCCCACCACACGTCGGCCCCCCACCACTGCCCCCAGCCGTGTGCCCGGACGTCGGCCCCCGGCCCCCCAGCAGCCTCCAAAGCCCTGTGACTCACAGCCCTGCTTCCACGGGGGGACCTGCCAGGACTGGGCATTGGGCGGGGGCTTCACCTGCAGCTGCCCGGCAGGCAGGGGAGGCGCCGTCTGTGAGAAGGTGCTTGGCGCCCCTGTGCCGGCCTTCGAGGGCCGCTCCTTCCTGGCCTTCCCCACTCTCCGCGCCTACCACACGCTGCGCCTGGCACTGGAATTCCGGGCGCTGGAGCCTCAGGGGCTGCTGCTGTACAATGGCAACGCCCGGGGCAAGGACTTCCTGGCATTGGCGCTGCTAGATGGCCGCGTGCAGCTCAGGTTTGACACAGGTTCGGGGCCGGCGGTGCTGACCAGTGCCGTGCCGGTAGAGCCGGGCCAGTGGCACCGCCTGGAGCTGTCCCGGCACTGGCGCCGGGGCACCCTCTCGGTGGATGGTGAGACCCCTGTTCTGGGCGAGAGTCCCAGTGGCACCGACGGCCTCAACCTGGACACAGACCTCTTTGTGGGCGGCGTACCCGAGGACCAGGCTGCCGTGGCGCTGGAGCGGACCTTCGTGGGCGCCGGCCTGAGGGGGTGCATCCGTTTGCTGGACGTCAACAACCAGCGCCTGGAGCTTGGCATTGGGCCGGGGGCTGCCACCCGAGGCTCTGGCGTGGGCGAGTGCGGGGACCACCCCTGCCTGCCCAACCCCTGCCATGGCGGGGCCCCATGCCAGAACCTGGAGGCTGGAAGGTTCCATTGCCAGTGCCCGCCCGGCCGCGTCGGACCAACCTGTGCCGATGAGAAGAGCCCCTGCCAGCCCAACCCCTGCCATGGGGCGGCGCCCTGCCGTGTGCTGCCCGAGGGTGGTGCTCAGTGCGAGTGCCCCCTGGGGCGTGAGGGCACCTTCTGCCAGACAGCCTCGGGGCAGGACGGCTCTGGGCCCTTCCTGGCTGACTTCAACGGCTTCTCCCACCTGGAGCTGAGAGGCCTGCACACCTTTGCACGGGACCTGGG endometrial cancer 29334253 Circular RNA expression in extracellular vesicles isolated from serum of patients with endometrial cancer. Xu H, Gong Z, Shen Y, Fang Y, Zhong S. Epigenomics. 2018 up RNA-seq, northern blots extracellular vesicles isolated from serum of patients with endometrial cancer hsa_circ_0009224 circRNA homo sapiens AGRN hsa_circ_0009224 ACCGCTGCGGGCAGTGCCGCTTTGGAGCCCTGTGCGAGGCCGAGACCGGGCGCTGCGTGTGCCCCTCTGAATGCGTGGCTTTGGCCCAGCCCGTGTGTGGCTCCGACGGGCACACGTACCCCAGCGAGTGCATGCTGCACGTGCACGCCTGCACACACCAGATCAGCCTGCACGTGGCCTCAGCTGGACCCTGTGAGACCTGTGGAGATGCCGTGTGTGCTTTTGGGGCTGTGTGCTCCGCAGGGCAGTGTGTGTGTCCCCGGTGTGAGCACCCCCCGCCCGGCCCCGTGTGTGGCAGCGACGGTGTCACCTACGGCAGTGCCTGCGAGCTACGGGAAGCCGCCTGCCTCCAGCAGACACAGATCGAGGAGGCCCGGGCAGGGCCGTGCGAGCAGGCCGAGTGCGGTTCCGGAGGCTCTGGCTCTGGGGAGGACGGTGACTGTGAGCAGGAGCTGTGCCGGCAGCGCGGTGGCATCTGGGACGAGGACTCGGAGGACGGGCCGTGTGTCTGTGACTTCAGCTGCCAGAGTGTCCCAGGCAGCCCGGTGTGCGGCTCAGATGGGGTCACCTACAGCACCGAGTGTGAGCTGAAGAAGGCCAGGTGTGAGTCACAGCGAGGGCTCTACGTAGCGGCCCAGGGAGCCTGCCGAGGCCCCACCTTCGCCCCGCTGCCGCCTGTGGCCCCCTTACACTGTGCCCAGACGCCCTACGGCTGCTGCCAGGACAATATCACCGCAGCCCGGGGCGTGGGCCTGGCTGGCTGCCCCAGTGCCTGCCAGTGCAACCCCCATGGCTCTTACGGCGGCACCTGTGACCCAGCCACAGGCCAGTGCTCCTGCCGCCCAGGTGTGGGGGGCCTCAGGTGTGACCGCTGTGAGCCTGGCTTCTGGAACTTTCGAGGCATCGTCACCGATGGCCGGAGTGGCTGTACACCCTGCAGCTGTGATCCCCAAGGCGCCGTGCGGGATGACTGTGAGCAGATGACGGGGCTGTGCTCGTGTAAGCCCGGGGTGGCTGGACCCAAGTGTGGGCAGTGTCCAGACGGCCGTGCCCTGGGCCCCGCGGGCTGTGAAGCTGACGCTTCTGCGCCTGCGACCTGTGCGGAGATGCGCTGTGAGTTCGGTGCGCGGTGCGTGGAGGAGTCTGGCTCAGCCCACTGTGTCTGCCCGATGCTCACCTGTCCAGAGGCCAACGCTACCAAGGTCTGTGGGTCAGATGGAGTCACATACGGCAACGAGTGTCAGCTGAAGACCATCGCCTGCCGCCAGGGCCTGCAAATCTCTATCCAGAGCCTGGGCCCGTGCCAGGAGGCTGTTGCTCCCAGCACTCACCCGACATCTGCCTCCGTGACTGTGACCACCCCAGGGCTCCTCCTGAGCCAGGCACTGCCGGCCCCCCCCGGCGCCCTCCCCCTGGCTCCCAGCAGTACCGCACACAGCCAGACCACCCCTCCGCCCTCATCACGACCTCGGACCACTGCCAGCGTCCCCAGGACCACCGTGTGGCCCGTGCTGACGGTGCCCCCCACGGCACCCTCCCCTGCACCCAGCCTGGTGGCGTCCGCCTTTGGTGAATCTGGCAGCACTGATGGAAGCAGCGATGAGGAACTGAGCGGGGACCAGGAGGCCAGTGGGGGTGGCTCTGGGGGGCTCGAGCCCTTGGAGGGCAGCAGCGTGGCCACCCCTGGGCCACCTGTCGAGAGGGCTTCCTGCTACAACTCCGCGTTGGGCTGCTGCTCTGATGGGAAGACGCCCTCGCTGGACGCAGAGGGCTCCAACTGCCCCGCCACCAAGGTGTTCCAGGGCGTCCTGGAGCTGGAGGGCGTCGAGGGCCAGGAGCTGTTCTACACGCCCGAGATGGCTGACCCCAAGTCAGAACTGTTCGGGGAGACAGCCAGGAGCATTGAGAGCACCCTGGACGACCTCTTCCGGAATTCAGACGTCAAGAAGGATTTTCGGAGTGTCCGCTTGCGGGACCTGGGGCCCGGCAAATCCGTCCGCGCCATTGTGGATGTGCACTTTGACCCCACCACAGCCTTCAGGGCACCCGACGTGGCCCGGGCCCTGCTCCGGCAGATCCAGGTGTCCAGGCGCCGGTCCTTGGGGGTGAGGCGGCCGCTGCAGGAGCACGTGCGATTTATGGACTTTGACTGGTTTCCTGCGTTTATCACGGGGGCCACGTCAGGAGCCATTGCTGCGGGAGCCACGGCCAGAGCCACCACTGCATCGCGCCTGCCGTCCTCTGCTGTGACCCCTCGGGCCCCGCACCCCAGTCACACAAGCCAGCCCGTTGCCAAGACCACGGCAGCCCCCACCACACGTCGGCCCCCCACCACTGCCCCCAGCCGTGTGCCCGGACGTCGGCCCCCGGCCCCCCAGCAGCCTCCAAAGCCCTGTGACTCACAGCCCTGCTTCCACGGGGGGACCTGCCAGGACTGGGCATTGGGCGGGGGCTTCACCTGCAGCTGCCCGGCAGGCAGGGGAGGCGCCGTCTGTGAGAAGGTGCTTGGCGCCCCTGTGCCGGCCTTCGAGGGCCGCTCCTTCCTGGCCTTCCCCACTCTCCGCGCCTACCACACGCTGCGCCTGGCACTGGAATTCCGGGCGCTGGAGCCTCAGGGGCTGCTGCTGTACAATGGCAACGCCCGGGGCAAGGACTTCCTGGCATTGGCGCTGCTAGATGGCCGCGTGCAGCTCAGGTTTGACACAGGTTCGGGGCCGGCGGTGCTGACCAGTGCCGTGCCGGTAGAGCCGGGCCAGTGGCACCGCCTGGAGCTGTCCCGGCACTGGCGCCGGGGCACCCTCTCGGTGGATGGTGAGACCCCTGTTCTGGGCGAGAGTCCCAGTGGCACCGACGGCCTCAACCTGGACACAGACCTCTTTGTGGGCGGCGTACCCGAGGACCAGGCTGCCGTGGCGCTGGAGCGGACCTTCGTGGGCGCCGGCCTGAGGGGGTGCATCCGTTTGCTGGACGTCAACAACCAGCGCCTGGAGCTTGGCATTGGGCCGGGGGCTGCCACCCGAGGCTCTGGCGTGGGCGAGTGCGGGGACCACCCCTGCCTGCCCAACCCCTGCCATGGCGGGGCCCCATGCCAGAACCTGGAGGCTGGAAGGTTCCATTGCCAGTGCCCGCCCGGCCGCGTCGGACCAACCTGTGCCGATGAGAAGAGCCCCTGCCAGCCCAACCCCTGCCATGGGGCGGCGCCCTGCCGTGTGCTGCCCGAGGGTGGTGCTCAGTGCGAGTGCCCCCTGGGGCGTGAGGGCACCTTCTGCCAGACAGCCTCGGGGCAGGACGGCTCTGGGCCCTTCCTGGCTGACTTCAACGGCTTCTCCCACCTGGAGCTGAGAGGCCTGCACACCTTTGCACGGGACCTGGGGGAGAAGATGGCGCTGGAGGTCGTGTTCCTGGCACGAGGCCCCAGCGGCCTCCTGCTCTACAACGGGCAGAAGACGGACGGCAAGGGGGACTTCGTGTCGCTGGCACTGCGGGACCGCCGCCTGGAGTTCCGCTACGACCTGGGCAAGGGGGCAGCGGTCATCAGGAGCAGGGAGCCAGTCACCCTGGGAGCCTGGACCAGGGTCTCACTGGAGCGAAACGGCCGCAAGGGTGCCCTGCGTGTGGGCGACGGCCCCCGTGTGTTGGGGGAGTCCCCGGTTCCGCACACCGTCCTCAACCTGAAGGAGCCGCTCTACGTAGGGGGCGCTCCCGACTTCAGCAAGCTGGCCCGTGCTGCTGCCGTGTCCTCTGGCTTCGACGGTGCCATCCAGCTGGTCTCCCTCGGAGGCCGCCAGCTGCTGACCCCGGAGCACGTGCTGCGGCAGGTGGACGTCACGTCCTTTGCAGGTCACCCCTGCACCCGGGCCTCAGGCCACCCCTGCCTCAATGGGGCCTCCTGCGTCCCGAGGGAGGCTGCCTATGTGTGCCTGTGTCCCGGGGGATTCTCAGGACCGCACTGCGAGAAGGGGCTGGTGGAGAAGTCAGCGGGGGACGTGGATACCTTGGCCTTTGACGGGCGGACCTTTGTCGAGTACCTCAACGCTGTGACCGAGAG endometrial cancer 29334253 Circular RNA expression in extracellular vesicles isolated from serum of patients with endometrial cancer. Xu H, Gong Z, Shen Y, Fang Y, Zhong S. Epigenomics. 2018 up RNA-seq, northern blots extracellular vesicles isolated from serum of patients with endometrial cancer hsa_circ_0009723 circRNA homo sapiens PGD hsa_circ_0009723 GGCCGCAGTTTCTGGAGGGAGCCGCTGCGGGTCTTTCCCTCACTCGTCCTCCGCGCGTCGCCGCTCTTCGGTTCTGCTCTGTCCGCCGCCATGGCCCAAGCTGACATCGCGCTGATCGGATTGGCCGTCATGGGCCAGAACTTAATTCTGAACATGAATGACCACGGCTTTGTGGTCTGTGCTTTTAATAGGACTGTCTCCAAAGTTGATGATTTCTTGGCCAATGAGGCAAAGGGAACCAAAGTGGTGGGTGCCCAGTCCCTGAAAGAGATGGTCTCCAAGCTGAAGAAGCCCCGGCGGATCATCCTCCTGGTGAAGGCTGGGCAAGCTGTGGATGATTTCATCGAGAAATTGGTACCATTGTTGGATACTGGTGACATCATCATTGACGGAGGAAATTCTGAATATAGGGACACCACAAGACGGTGCCGAGACCTCAAGGCCAAGGGAATTTTATTTGTGGGGAGCGGAGTCAGTGGTGGAGAGGAAGGGGCCCGGTATGGCCCATCGCTCATGCCAGGAGGGAACAAAGAAGCGTGGCCCCACATCAAGACCATCTTCCAAGGCATTGCTGCAAAAGTGGGAACTGGAGAACCCTGCTGTGACTGGGTGGGAGATGAGGGAGCAGGCCACTTCGTGAAGATGGTGCACAACGGGATAGAGTATGGGGACATGCAGCTGATCTGTGAGGCATACCACCTGATGAAAGACGTGCTGGGCATGGCGCAGGACGAGATGGCCCAGGCCTTTGAGGATTGGAATAAGACAGAGCTAGACTCATTCCTGATTGAAATCACAGCCAATATTCTCAAGTTCCAAGACACCGATGGCAAACACCTGCTGCCAAAGATCAGGGACAGCGCGGGGCAGAAGGGCACAGGGAAGTGGACCGCCATCTCCGCCCTGGAATACGGCGTACCCGTCACCCTCATTGGAGAAGCTGTCTTTGCTCGGTGCTTATCATCTCTGAAGGATGAGAGAATTCAAGCTAGCAAAAAGCTGAAGGGTCCCCAGAAGTTCCAGTTTGATGGTGATAAGAAATCATTCCTGGAGGACATTCGGAAGGCACTCTACGCTTCCAAGATCATCTCTTACGCTCAAGGCTTTATGCTGCTAAGGCAGGCAGCCACCGAGTTTGGCTGGACTCTCAATTATGGTGGCATCGCCCTGATGTGGAGAGGGGGCTGCATCATTAGAAGTGTATTCCTAGGAAAGATAAAGGATGCATTTGATCGAAACCCGGAACTTCAGAACCTCCTACTGGACGACTTCTTTAAGTCAGCTGTTGAAAACTGCCAGGACTCCTGGCGGCGGGCAGTCAGCACTGGGGTCCAGGCTGGCATTCCCATGCCCTGTTTTACCACTGCCCTCTCCTTCTATGACGGGTACAGACATGAGATGCTTCCAGCCAGCCTCATCCAGGCTCAGCGGGATTACTTCGGGGCTCACACCTATGAACTCTTGGCCAAACCAGGGCAGTTTATCCACACCAACTGGACAGGCCATGGTGGCACCGTGTCATCCTCGTCATACAATGCCTGATCATGCTGCTCCTGTCACCCTCCACGATTCCACAGACCAGGACATTCCATGTGCCTCATGGCACTGCCACCTGGCCCTTTGCCCTATTTTCTGTTCAGTTTTTTAAAAGTGTTGTAAGAGACTCCTGAGGAAGACACACAGTTTATTTGTAAAGTAGCTCTGTGAGAGCCACCATGCCCTCTGCCCTTGCCTCTTGGGACTGACCAGGAGCTGCTCATGTGCGTGAGAGTGGGAACCATCTCCTTGCGGCAGTGGCTTCCGCGTGCCCCGTGTGCTGGTGCGGTTCCCATCACGCAGACAGGAAGGGTGTTTGCGCACTCTGATCAACTGGAACCTCTGTATCATGCGGCTGAATTCCCTTTTTCCTTTACTCAATAAAAGCTACATCAGACTGA hepatocellular carcinoma 29144509 Circular RNA expression is suppressed by androgen receptor (AR)-regulated adenosine deaminase that acts on RNA (ADAR1) in human hepatocellular carcinoma. Shi L, Yan P, Liang Y, Sun Y, Shen J, Zhou S, Lin H, Liang X, Cai X. Cell Death Dis. 2017 upregulated more than fivefold as revealed by circRNA microarray after AR knocking down in MHCC-108h cells microarray, qRT-PCR MHCC-97h, LM3 and LO14 cells hsa_circ_000984 circRNA homo sapiens CDK6 hsa_circ_0001724 CDK6, hsa_circ_000984 GGCAGGAGCGCGCGGAGGGTAGCGATGGAGGCTTCGTAAAGGAGGAGGAGGGGAGTCTGGAGGAACCCCGAGGAAGGCTTCTGGGCTGTCTGATTGCACTTTCTTCTTATCCTCCCGTCTCCTCCTTTAGGTGCAATGATTCTGGACTGAGACGCGCTTGGGCAGAGGCTATGTAATCGTGTCTGTGTTGAGGACTTCGCTTCGAGGAGGGAAGAGGAGGGATCGGCTCGCTCCTCCGGCGGCGGCGGCGGCGGCGACTCTGCAGGCGGAGTTTCGCGGCGGCGGCACCAGGGTTACGCCAGCCCCGCGGGGAGGTCTCTCCATCCAGCTTCTGCAGCGGCGAAAGCCCCAGCGCCCGAGCGCCTGAGCCGGCGGGGAGCAAGTAAAGCTAGACCGATCTCCGGGGAGCCCCGGAGTAGGCGAGCGGCGGCCGCCAGCTAGTTGAGCGCACCCCCCGCCCGCCCCAGCGGCGCCGCGGCGGGCGGCGTCCAGGCGGCATGGAGAAGGACGGCCTGTGCCGCGCTGACCAGCAGTACGAATGCGTGGCGGAGATCGGGGAGGGCGCCTATGGGAAGGTGTTCAAGGCCCGCGACTTGAAGAACGGAGGCCGTTTCGTGGCGTTGAAGCGCGTGCGGGTGCAGACCGGCGAGGAGGGCATGCCGCTCTCCACCATCCGCGAGGTGGCGGTGCTGAGGCACCTGGAGACCTTCGAGCACCCCAACGTG Colorectal Cancer 29207676 Circular RNA hsa_circ_000984 promotes colon cancer growth and metastasis by sponging miR-106b. Xu XW, Zheng BA, Hu ZM, Qian ZY, Huang CJ, Liu XQ, Wu WD. Oncotarget. 2017 hsa_circ_000984 was remarkably upregulated in the tissues of colorectal cancer (CRC) patients and in the CRC cell lines. qRT-PCR CRC tumors and matched adjacent normal tissues, CCD-18Co, InEpC, SW480, SW620 and HT29 cells hsa_circ_000984 knockdown could inhibit cell proliferation, migration, invasion in vitro and tumor formation in vivo in CRC cell lines. loss of function SW480, SW620 nude mice miR-106b circRNA-miRNA CRC tumors and matched adjacent normal tissues expression miR-106b was highly expressed in CRC tissue samples (P<0.01), and its expression was positively correlated with hsa_ circ_000984 expression in CRC samples. CDK6 hsa_circ_0009910 circRNA homo sapiens MFN2 hsa_circ_0009910 CGCAATGTCCCTGCTCTTCTCTCGATGCAACTCTATCGTCACAGTCAAGAAAAATAAGAGACACATGGCTGAGGTGAATGCATCCCCACTTAAGCACTTTGTCACTGCCAAGAAGAAGATCAATGGCATTTTTGAGCAGCTGGGGGCCTACATCCAGGAGAGCGCCACCTTCCTTGAAGACACGTACAGGAATGCAGAACTGGACCCCGTTACCACAGAAGAACAGGTTCTGGACGTCAAAGGTTACCTATCCAAAGTGAGAGGCATCAGTGAGGTGCTGGCTCGGAGGCACATGAAAGTGGCTTTTTTTGGCCG osteosarcoma 29117539 Hsa_circ_0009910 promotes carcinogenesis by promoting the expression of miR-449a target IL6R in osteosarcoma. Deng N, Li L, Gao J, Zhou J, Wang Y, Wang C, Liu Y. Biochem Biophys Res Commun. 2018 overexpressed in osteosarcoma qRT-PCR hFOB, MG63, Saos-2 and U2OS, OS tissues and adjacent non-tumor tissues Knockdown of circ_0009910 induced cell proliferation inhibition, cell cycle arrest, and apoptosis in OS cells. loss of function MG63 miR-449a circRNA-miRNA MG63 luciferase reporter assay Direct interaction of circ_0009910 and miR-449a was confirmed through dual-luciferase assays. IL6R hsa_circ_0010235 circRNA homo sapiens ALDH4A1 hsa_circ_0010235 CCTGCGGTGGAAGCACACCTCCTCCCTGAAGGTGGCCAACGAGCCCGTCTTAGCCTTCACGCAGGGCAGCCCTGAGCGAGATGCCCTGCAAAAGGCCTTGAAGGACCTGAAGGGCCGGATGGAAGCCATCCCATGCGTGGTGGGGGATGAGGAGGTGTGGACGTCGGACGTGCAGTACCAAGTGTCGCCTTTTAACCATGGACATAAGGTGGCCAAGTTCTGTTATGCAGACAAGAGCCTGCTCAACAAAGCCATTGAGGCTGCCCTGGCTGCCCGGAAAGAGTGGGACCTGAAGCCTATTGCAGACCGGGCCCAGATCTTCCTGAAGGCGGCAGACATGCTGAGTGGGCCGCGCAGGGCTGAGATCCTCGCCAAGACCATGGTGGGACAGGGTAAGACCGTGATCCAAGCGGAGATTGACGCTGCAGCGGAACTCATCGACTTCTTCCGGTTCAATGCCAAGTATGCGGTGGAGCTGGAGGGGCAGCAGCCCATCAGCGTGCCCCCGAGCACCAACAGCACGGTGTACCGGGGTCTGGAGGGCTTCGTGGCGGCCATCTCGCCCTTTAACTTCACTGCAATCGGCGGCAACCTGGCGGGGGCACCGGCCCTGATGGGCAACGTGGTCCTATGGAAGCCCAGTGACACTGCCATGCTGGCCAGCTATGCTGTCTACCGCATCCTTCGGGAGGCTGGCCTGCCCCCCAACATCATCCAGTTTGTGCCAGCTGATGGGCCCCTATTTGGGGACACTGTCACCAGCTCAGAGCACCTCTGTGGCATCAACTTCACAGGCAGTGTGCCCACCTTCAAACACCTGTGGAAGCAGGTGGCCCAGAACCTGGACCGGTTCCACACCTTCCCACGCCTGGCTGGAGAGTGCGGCGGAAAGAACTTCCACTTCGTGCACCGCTCGGCCGACGTGGAGAGCGTGGTGAGCGGGACCCTCCGCTCAGCCTTCGAGTACGGTGGCCAGAAGTGTTCCGCGTGCTCGCGTCTCTACGTGCCGCACTCGCTGTGGCCGCAGATCAAAGGGCGGCTGCTGGAGGAGCACAGTCGGATCAAAGTGGGCGACCCTGCAGAGGATTTTGGGACCTTCTTCTCTGCAGTGATTGATGCCAAGTCCTTTGCCCGTATCAAGAAGTGGCTGGAGCACGCACGCTCCTCACCCAGCCTCACCATCCTGGCCGGGGGCAAGTGTGATGACTCCGTGGGCTACTTTGTGGAGCCCTGCATCGTGGAGAGCAAGGACCCTCAGGAGCCCATCATGAAGGAGGAGATCTTCGGGCCTGTACTGTCTGTGTACGTCTACCCGGATGACAAGTACAAGGAGACGCTGCAGCTGGTTGACAGCACCACCAGCTATGGCCTCACGGGGGCAGTGTTCTCCCAGGATAA Non-small cell lung cancer 29372377 Microarray profiles reveal that circular RNA hsa_circ_0007385 functions as an oncogene in non-small cell lung cancer tumorigenesis. Jiang MM, Mai ZT, Wan SZ, Chi YM, Zhang X, Sun BH, Di QG. J Cancer Res Clin Oncol. 2018 upregulated microarray, qRT-PCR NSCLC tissue and adjacent non-cancerous lung tissue hsa_circ_0010729 circRNA homo sapiens HSPG2 hsa_circ_0010729 GTGGACTCCTATGGCGGCTCCCTGCGTTACAACGTGCGCTACGAGTTGGCCCGTGGCATGCTGGAGCCAGTGCAGCGGCCGGACGTGGTCCTCATGGGTGCCGGGTACCGCCTCCTCTCCCGAGGCCACACACCCACCCAACCTGGTGCTCTGAACCAGCGCCAGGTCCAGTTCTCTGAGGAGCACTGGGTCCATGAGTCTGGCCGGCCGGTGCAGCGCGCGGAGCTGCTGCAGGTGCTGCAGAGCCTGGAGGCCGTGCTCATCCAGACCGTGTACAACACCAAGATGGCCAGCGTGGGACTTAGCGACATCGCCATGGATACCACCGTCACCCATGCCACCAGCCATGGCCGTGCCCACAGTGTGGAGGAGTGCAGATGCCCCATTGGCTATTCTGGCTTGTCCTGCGAGAGCTGTGATGCCCACTTCACTCGGGTGCCTGGTGGGCCCTACCTGGGCACCTGCTCTGGTTGCAATTGCAATGGCCATGCCAGCTCCTGTGACCCTGTGTATGGCCACTGCCTGAATTGCCAGCACAACACGGAGGGGCCACAGTGCAACAAGTGCAAGGCTGGCTTCTTTGGGGACGCCATGAAGGCCACGGCCACTTCCTGCCGGCCCTGCCCTTGCCCATACATCGATGCCTCCCGCAGATTCTCAGACACTTGCTTCCTGGACACGGATGGCCAAGCCACATGTGACGCCTGTGCCCCAGGCTACACTGGCCGCCGCTGTGAGAGCTGTGCCCCCGGATACGAGGGCAACCCCATCCAGCCCGGCGGGAAGTGCAGGCCCGTCAACCAGGAGATTGTGCGCTGTGACGAGCGTGGCAGCATGGGGACCTCCGGGGAGGCCTGCCGCTGTAAGAACAATGTGGTGGGGCGCTTGTGCAATGAATGTGCTGACGGCTCTTTCCACCTGAGTACCCGAAACCCCGATGGCTGCCTCAAGTGCTTCTGCATGGGTGTCAGTCGCCACTGCACCAGCTCTTCATGGAGCCGTGCCCAGTTGCATGGGGCCTCTGAGGAGCCTGGTCACTTCAGCCTGACCAACGCCGCAAGCACCCACACCACCAACGAGGGCATCTTCTCCCCCACGCCCGGGGAACTGGGATTCTCCTCCTTCCACAGACTCTTATCTGGACCCTACTTCTGGAGCCTCCCTTCACGCTTCCTGGGGGACAAGGTGACCTCCTATGGAGGAGAGCTGCGCTTCACAGTGACCCAGAGGTCCCAGCCGGGCTCCACACCCCTGCACGGGCAGCCGTTGGTGGTGCTGCAAGGTAACAACATCATCCTAGAGCACCATGTGGCCCAGGAGCCCAGCCCCGGCCAGCCCAGCACCTTCATTGTGCCTTTCCGGGAGCAAGCATGGCAGCGGCCCGATGGGCAGCCAGCCACACGGGAGCACCTGCTGATGGCACTGGCAGGCATCGACACCCTCCTGATCCGAGCATCCTACGCCCAGCAGCCCGCTGAGAGCAGGGTCTCTGGCATCAGCATGGACGTGGCTGTGCCCGAGGAAACCGGCCAGGACCCCGCGCTGGAAGTGGAACAGTGCTCCTGCCCACCCGGGTACCGTGGGCCGTCCTGCCAGGACTGTGACACAGGCTACACACGCACGCCCAGTGGCCTCTACCTGGGTACCTGTGAACGCTGCAGCTGCCATGGCCACTCAGAGGCCTGCGAGCCAGAAACAGGTGCCTGCCAGGGCTGCCAGCATCACACGGAGGGCCCTCGGTGTGAGCAGTGCCAGCCAGGATACTACGGGGACGCCCAGCGGGGGACACCACAGGACTGCCAGCTGTGCCCCTGCTACGGAGACCCTGCTGCCGGCCAGGCTGCCCACACTTGTTTTCTGGACACAGACGGCCACCCCACCTGTGATGCGTGCTCCCCAGGCCACAGTGGGCGTCACTGTGAGAGGTGCGCCCCTGGCTACTATGGCAACCCCAGCCAGGGCCAGCCATGCCAGAGAGACAGCCAGGTGCCAGGGCCCATAGGCTGCAACTGTGACCCCCAAGGCAGCGTCAGCAGCCAGTGTGATGCTGCTGGTCAGTGCCAGTGCAAGGCCCAGGTGGAAGGCCTCACTTGCAGCCACTGCCGGCCCCACCACTTCCACCTGAGTGCCAGCAACCCAGACGGCTGCCTGCCCTGCTTCTGTATGGGCATCACCCAGCAGTGCGCCAGCTCTGCCTACACACGCCACCTGATCTCCACCCACTTTGCCCCTGGGGACTTCCAAGGCTTTGCCCTGGTGAACCCACAGCGAAACAGCCGCCTGACAGGAGAATTCACTGTGGAACCCGTGCCCGAGGGTGCCCAGCTCTCTTTTGGCAACTTTGCCCAACTCGGCCATGAGTCCTTCTACTGGCAGCTGCCGGAGACATACCAGGGAGACAAGGTGGCGGCCTACGGTGGGAAGTTGCGATACACCCTCTCCTACACAGCAGGCCCACAGGGCAGCCCACTCTCTGACCCCGATGTGCAGATCACGGGCAACAACATCATGCTAGTGGCCTCCCAGCCAGCGCTGCAGGGCCCTGAGAGGAGGAGCTACGAGATCATGTTCCGAGAGGAATTCTGGCGCCGGCCCGATGGGCAGCCGGCCACACGCGAGCACCTCCTGATGGCACTGGCCGACCTGGATGAGCTCCTGATCCGGGCCACGTTCTCCTCCGTGCCGCTGGCGGCCAGCATCAGCGCAGTCAGCCTGGAGGTCGCCCAGCCGGGGCCCTCAAACAGACCCCGCGCCCTCGAGGTGGAGGAGTGCCGCTGCCCGCCAGGCTACATCGGTCTGTCCTGCCAGGACTGTGCCCCCGGCTACACGCGCACCGGGAGTGGGCTCTACCTCGGCCACTGCGAGCTATGTGAATGCAATGGCCACTCAGACCTGTGCCACCCAGAGACTGGGGCCTGCTCGCAATGCCAGCACAACGCCGCAGGGGAGTTCTGCGAGCTTTGTGCCCCTGGCTACTACGGAGATGCCACAGCCGGGACGCCTGAGGACTGCCAGCCCTGTGCCTGCCCACTGACCAACCCAGAGAACATGTTTTCCCGCACCTGTGAGAGCCTGGGAGCCGGCGGGTACCGCTGCACGGCCTGCGAACCCGGCTACACTGGCCAGTACTGTGAGCAGTGTGGCCCAGGTTACGTGGGTAACCCCAGTGTGCAAGGGGGCCAGTGCCTGCCAGAGACAAACCAAGCCCCACTGGTGGTCGAGGTCCATCCTGCTCGAAGCATAGTGCCCCAAGGTGGCTCCCACTCCCTGCGGTGTCAGGTCAGTGGGAGCCCACCCCACTACTTCTATTGGTCCCGTGAGGATGGGCGGCCTGTGCCCAGCGGCACCCAGCAGCGACATCAAGGCTCCGAGCTCCACTTCCCCAGCGTCCAGCCCTCGGATGCTGGGGTCTACATTTGCACCTGCCGTAATCTCCACCAATCCAATACCAGCCGGGCAGAGCTGCTGGTCACTG cardiovascular disease 28571741 Circular RNA hsa_circ_0010729 regulates vascular endothelial cell proliferation and apoptosis by targeting the miR-186/HIF-1α axis. Dang RY, Liu FL, Li Y. Biochem Biophys Res Commun. 2017 Hsa_circ_0010729 was selected as target for the validation of microarray analysis and its expression was verified using RT-PCR in HUVECs exposed to hypoxia at 6 h, 12 h and 24 h respectively. RT-PCR showed that hsa_circ_0010729 expression was significantly increased in hypoxia, presenting a dosage-dependent relationship. qRT-PCR, microarray human umbilical vein endothelial cells In loss-of-function experiments of HUVECs, hsa_circ_0010729 knockdown suppressed the proliferation and migration ability and enhanced apoptosis. the present study identifies the crucial regulation of hsa_circ_0010729 on vascular endothelial cell proliferation and apoptosis via targeting miR-186/HIF-1alpha axis. loss of function human umbilical vein endothelial cells miR-186 circRNA-miRNA human umbilical vein endothelial cells luciferase reporter assay miR-186 shares binding sites with has_circ_0010729 and the sequences were shown as follows, moreover, the binding was validated by luciferase reporter assay. Using RT-PCR, we detected and verified the down-regulated expression in hypoxia-induced HUVECs, showing the negative correlation with has_circ_0010729 expression. HIF-1alpha hsa_circ_0011542 circRNA homo sapiens ZMYM4 hsa_circ_0011542 AGACATTTTAAATCCAAAGGATGTGATCAGTGCCCAGTTTGAAAACACCACCACTAGTAAAGATTTTTGCAGTCAGTCATGTTTGTCAACATATGAACTGAAAAAAAAACCTATTGTTACCATAAATACAAATAGTATTTCAACCAAATGCAGCATGTGTCAGAAGAATGCTGTTATTCGACATGAAGTTAATTACCAGAATGTGGTCCATAAACTTTGCAGTGATGCCTGCTTCTCTAAGTTTCGTTCTGCTAACAACCTCACCATGAACTGTTGTGAGAACTGTGGGGGTTACTGTTACAGTGGGTCGGGACAATGCCACATGCTTCAGATAGAGGGACAGTCTAAGAAGTTTTGTAGTTCATCGTGTATCACGGCATACAAGCAGAAATCAGCCAAAATTACACCGTGTGCGCTTTGCAAATCATTGAGATCCTCAGCAGAAATGATTGAAAATACCAATAGCTTGGGGAAGACAGAGCTTTTCTGTTCTGTTAATTGCTTATCTGCTTACAGAGTTAAAATGGTTACTTCTGCAGGTGTACAAGTTCAGTGTAACAGTTGTAAAACCTCAGCAATTCCTCAGTATCACCTAGCCATGTCAGATGGAAGTATACGCAACTTCTGCAGCTACAGCTGTGTGGTAGCTTTCCAGAATTTATTCAACAAACCAACTGGAATGAATTCTTCAGTAGTGCCCTTGTCTCAGGGCCAAGTAATTGTAAGCATCCCCACAGGTTCCACAGTGTCAGCCGGAGGAGGTAGCACATCTGCTGTTTCTCCCACCTCCATCAGTAGCTCTGCTGCAGCTGGTCTCCAGCGTCTCGCTGCCCAGTCCCAGCATGTTGGGTTTGCACGAAGTGTTGTGAAACTCAAATGTCAACACTGTAACCGTCTTTTTGCCACAAAACCAGAACTTCTTGACTATAAGGGCAAAATGTTTCAGTTCTGTGGCAAGAATTGTTCTGATGAATATAAGAAAATAAATAATGTAATGGCAATGTGTGAATATTGTAAAATTGAGAAAATTGTAAAGGAGACTGTTCGGTTCTCAGGTGCTGACAAGTCATTCTGTAGTGAAGGTTGCAAATTGCTTTATAAACATGACTTGGCAAAACGCTGGGGAAATCACTGTAAAATGTGCAGTTATTGTTTACAGACATCTCCCAAATTGGTACAGAATAATTTAGGAGGGAAAGTGGAAGAGTTCTGTTGTGAAGAATGCATGTCCAAATATACAGTTTTGTTCTATCAGATGGCCAAATGTGATGCTTGTAAGCGACAGGGTAAACTCAGTGAGTCCTTGAAATGGCGAGGGGAAATGAAACATTTCTGTAACCTGCTTTGTATCTTGATGTTCTGTAATCAGCAAAGTGTATGTGACCCGCCTTCACAAAATAATGCAG hepatocellular carcinoma 29144509 Circular RNA expression is suppressed by androgen receptor (AR)-regulated adenosine deaminase that acts on RNA (ADAR1) in human hepatocellular carcinoma. Shi L, Yan P, Liang Y, Sun Y, Shen J, Zhou S, Lin H, Liang X, Cai X. Cell Death Dis. 2017 upregulated more than fivefold as revealed by circRNA microarray after AR knocking down in MHCC-110h cells microarray, qRT-PCR MHCC-97h, LM3 and LO16 cells hsa_circ_0011946 circRNA homo sapiens SCMH1 hsa_circ_0011946 CATCTAGTGCTTTTTGCATGGCCCAAAGGGGCTCTGTGCTGCTCCACTACAGAGGAAACTTCAAGAAATGCTGGTTTGCTACAGTGTTTTAGCTTGTGAGATTCTCTGGGACCTTCCCTGCTCCATCATGGGGTCACCTCTAGGTCATTTTACCTGGGACAAATACCTAAAAGAAACATGTTCAGTCCCAGCGCCTGTCCATTGCTTCAAGCAGTCCTACACACCTCCAAGCAACGAGTTCAAGATCAGTATGAAATTGGAAGCACAGGACCCCAGGAACACCACATCCACCTGTATTGCCACAGTAGTTGGACTGACAGGTGCCCGCCTTCGCCTGCGCCTTGATGGGAGCGACAACAAAAATGACTTCTGGCGGCTGGTTGACTCAGCTGAAATCCAGCCTATTGGGAACTGTGAAAAGAATGGGGGTATGCTACAGCCACCTCTTGGATTTCGGCTGAATGCGTCTTCTTGGCCCATGTTCCTTTTGAAGACGCTAAATGGAGCAGAGATGGCTCCCATCAGGATTTTCCACAAGGAGCCACCATCGCCTTCCCACAACTTCTTCAAAATGGGAATGAAGCTAGAAGCTGTGGACAGGAAGAACCCTCATTTCATTTGCCCAGCCACTATTGGGGAGGTTCGGGGCTCAGAGGTGCTTGTCACTTTTGATGGGTGGCGAGGGGCCTTTGACTACTGGTGCCGCTTCGACTCCCGAGACATCTTCCCTGTGGGCTGGTGTTCCTTGACTGGAGACAACCTGCAGCCTCCTGGCACCAAAG breast cancer 29593432 Downregulation of hsa_circ_0011946 suppresses the migration and invasion of the breast cancer cell line MCF-7 by targeting RFC3. Zhou J, Zhang WW, Peng F, Sun JY, He ZY, Wu SG. Cancer Manag Res. 2018 up-regulated in both cells and breast cancer tissues RNA-seq, qRT-PCR breast cancer and corresponding adjacent non-cancerous tissues, HS-578T, T47D, MCF-7, BT549, MDA-MB-231, and SKBR-3 Downregulated hsa_circ_0011946 inhibited RFC3 expression and migration, and invasion in MCF-7 cells. loss of function MCF-7 miR-26a/b circRNA-miRNA MCF-7 and MDA-MB-231 predicted From these studies, we deduced that hsa_circ_0011946, as a miRNA sponge, might regulate the progression of breast cancer by binding up miR-26a/b, miR-200b/c, and miR-429. RFC3 circRNF220 circRNA homo sapiens RNF220 hsa_circ_0012152 GTCTTAGGAGGGAATGATTCCCCAGTAATATTCCCTGCCCTGACCCAAAGTGCTGGTTGGCCTCCCTCCCAGGGAAGACTGCTTCTTGCGTAACGCCGGCCACAGAAAGAGACTCCGATGGACTTACACCGGGCAGCCTTCAAGATGGAGAACTCATCCTACCTTCCCAACCCTCTGGCATCCCCAGCACTGATGGTCCTGGCATCCACGGCTGAGGCCAGCCGTGATGCTTCCATCCCTTGTCAGCAGCCACGACCCTTTGGTGTACCTGTCTCAGTTGACAAGGACGTGCATATTCCTTTCACCAACGGTTCCTATACCTTTGCCTCTATGTACCATCGGCAAGGTGGGGTGCCAGGCACTTTTGCCAATCGTGATTTCCCCCCTTCTCTACTACACCTCCACCCTCAATTTGCTCCCCCAAATCTAGATTGCACCCCAATCAGTATGCTGAATCATAGTGGTGTGGGGGCTTTCCGGCCCTTTGCCTCCACCGAGGACCGGGAGAGCTATCAGTCAGCCTTTACGCCGGCCAAGCGACTTAAGAACTGCCATGACACAGAGTCTCCCCACTTGCGCTTCTCAGATGCAGATGGCAAGGAATATGACTTTGGGACACAGCTGCCATCTAGCTCCCCCGGTTCACTAAAGGTTGATGACACTGGGAAGAAGATTTTTGCTGTCTCTGGCCTCATTTCTGATCGGGAAGCCTCATCTAGCCCAGAGGATCGGAATGACAGAT 24039610 Cell-type specific features of circular RNA expression. Salzman J, Chen RE, Olsen MN, Wang PL, Brown PO. PLoS Genet. 2013 HeLa RNA was treated with RNase R or a mock treatment, and then subjected to qPCR with isoform-specific primers. The fraction of linear and circular isoforms was normalized to the value measured in the mock treatment. All tested circular isoforms resisted RNase R. qRT-PCR HeLa hsa_circ_0012673 circRNA homo sapiens DHCR24 hsa_circ_0012673 ATTGTCCGTGTGGAGCCCTTGGTGACCATGGGCCAGGTGACTGCCCTGCTGACCTCCATTGGCTGGACTCTCCCCGTGTTGCCTGAGCTTGATGACCTCACAGTGGGGGGCTTGATCATGGGCACAGGCATCGAGTCATCATCCCACAAGTACGGCCTGTTCCAACACATCTGCACTGCTTACGAGCTGGTCCTGGCTGATGGCAGCTTTGTGCGATGCACTCCG lung adenocarcinoma 29366790 Increased circular RNA hsa_circ_0012673 acts as a sponge of miR-22 to promote lung adenocarcinoma proliferation. Wang X, Zhu X, Zhang H, Wei S, Chen Y, Chen Y, Wang F, Fan X, Han S, Wu G. Biochem Biophys Res Commun. 2018 The expression of hsa_circ_0012673 was up-regulated in LAC tissues compared to pair-matched adjacent non-tumor tissues (P = 0.0079). qRT-PCR LAC samples from stage I-III patients, H1792, A549, PC9, H1703, H1793, H1299, HBE Hsa_circ_0012673 knockdown could suppress the proliferation of LAC cells. Hsa_circ_0012673 knockdown could suppress tumour growth in vivo. Hsa_circ_0012673 expression was significant associated with tumour size (P= 0.0058). loss of function A549, PC9 BALB/c nu/nu male mice (4 weeks old) LAC samples from stage I-III patients miR-22 circRNA-miRNA A549, HEK293T RNA FISH, luciferase Colocalization of miR-22 and hsa_circ_0012673 was observed using RNA in situ hybridization in A549 cells. Only miR-22 reduced the luciferase reporter activity by at least 50% compared with the hsa_circ_0012673_mutant (P < 0.01). ErbB3 hsa_circ_0013255 circRNA homo sapiens DPYD hsa_circ_0013255 GACATTGTGACAAATGTTTCCCCCAGAATCATCCGGGGAACCACCTCTGGCCCCATGTATGGCCCTGGACAAAGCTCCTTTCTGAATATTGAGCTCATCAGTGAGAAAACGGCTGCATATTGGTGTCAAAGTGTCACTGAACTAAAGGCTGACTTTCCAGACAACATTGTGATTGCTAGCATTATGTGCAGTTACAATAAAAATGACTGGACGGAACTTGCCAAGAAGTCTGAGGATTCTGGAGCAGATGCCCTGGAGTTAAATTTATCATGTCCACATGGCATGGGAGAAAGAGGAATGGGCCTGGCCTGTGGGCAGGATCCAGAGCTGGTGCGGAACATCTGCCGCTGGGTTAGGCAAGCTGTTCAGATTCCTTTTTTTGCCAAGCTGACCCCAAATGTCACTGATATTGTGAGCATCGCAAGAGCTGCAAAGGAAGGTGGTGCCAATGGCGTTACAGCCACCAACACTGTCTCAGGTCTGATGGGATTAAAATCTGATGGCACACCTTGGCCAGCAGTGGGGATTGCAAAGCGAACTACATATGGAGGAGTGTCTGGGACAGCAATCAGACCTATTGCTTTGAGAGCTGTGACCTCCATTGCTCGTGCTCTGCCTGGATTTCCCATTTTGGCTACTGGTGGAATTGACTCTGCTGAAAGTGGTCTTCAGTTTCTCCATAGTGGTGCTTCCGTCCTCCAGGTATGCAGTGCCATTCAGAATCAGGATTTCACTGTGATCGAAGACTACTGCACTGGCCTCAAAGCCCTGCTTTATCTGAAAAGCATTGAAGAACTACAAGACTGGGATGGACAGAGTCCAGCTACTGTGAGTCACCAGAAAGGGAAACCAGTTCCACGTATAGCTGAACTCATGGACAAGAAACTGCCAAGTTTTGGACCTTATCTGGAACAGCGCAAGAAAATCATAGCAGAAAACAAGATTAGACTGAAAGAACAAAATGTAGCTTTTTCACCACTTAAGAGAAACTGTTTTATCCCCAAAAGGCCTATTCCTACCATCAAGGATGTAATAGGAAAAGCACTGCAGTACCTTGGAACATTTGGTGAATTGAGCAACGTAGAGCAAGTTGTGGCTATGATTGATGAAGAAATGTGTATCAACTGTGGTAAATGCTACATGACCTGTAATGATTCTGGCTACCAGGCTATACAGTTTGATCCAGAAACCCACCTGCCCACCATAACCGACACTTGTACAGGCTGTACTCTGTGTCTCAGTGTTTGCCCTATTGTCGACTGCATCAAAATGGTTTCCAGGACAACACCTTATGAACCAAAGAGAGGCGTACCCTTATCTGTGAATCCGGTGTGTTAAGGTGATTTGTGAAACAGTTGCTGTGAACTTTCATGTCACCTACATATGCTGATCTTTTAAAATCATGATCCTTGTGTTCAGCTCTTTCCAAATTAAAACAAATATACATTTTCTAAATAAAAATATGTAATTTCAAAATACATTTGTAAGTGTAAAAAATGTCTCATGTCAATGACCATTCAATTAGTGGTCATAAAATAGAATAATTCTTTTCTGAGGATAGTAGTTAAATAACTGTGTGGCAGTTAATTGGATGTTCACTGCCAGTTGTCTTATGTGAAAAATTAACTTTTTTGTGGCAATTAGTGTGACAGTTTCCAAATTGCCCTATGCTGTGCTCCATATTTGATTTCTAATTGTAAGTGAAATTAAGCATTTTGAAACAAAGTACTCTTTAACATACAAGAAAATGTATCCAAGGAAACATTTTATCATTAAAAATTACCTTTAATTTTAATGCTGTTTCTAAGAAAATGTAGTTAGCTCCATAAAGTACAAATGAAGAAAGTCAAAAAATTATTTGCTATGGCAGGATAAGAAAGCCTAAAATTGAGTTTGTAGAACTTTATTAAGTAAAATCCCCTTCGCTGAAATTGCTTATTTTTGGTGTTGGATAGAGGATAGGGAGAATATTTACTAACTAAATACCATTCACTACTCATGCGTGAGATGGGTGTACAAACTCATCCTCTTTTAATGGCATTTCTCTTTAAACTATGTTCCTAACAAAATGAGATGATAGGATAGATCCTGGTTACCACTCTTTTGCTGTGCACATACGGGCTCTGACTGGTTTTAATAGTCACCTTCATGATTATAGCAACTAATGTTTGAACAAAGCTCAAAGTATGCAATGCTTCATTATTCAAGAATGAAAAATATAATGTTGATAATATATATTAAGTGTGCCAAATCAGTTTGACTACTCTCTGTTTTAGTGTTTATGTTTAAAAGAAATATATTTTTTGTTATTATTAGATAATATTTTTGTATTTCTCTATTTTCATAATCAGTAAATAGTGTCATATAAACTCATTTATCTCCTCTTCATGGCATCTTCAATATGAATCTATAAGTAGTAAATCAGAAAGTAACAATCTATGGCTTATTTCTATGACAAATTCAAGAGCTAGAAAAATAAAATGTTTCATTATGCACTTTTAGAAATGCATATTTGCCACAAAACCTGTATTACTGAATAATATCAAATAAAATATCATAAAGCATTTTAA Radiation-induced liver fibrosis 28774651 Microarray profiling of circular RNAs and the potential regulatory role of hsa_circ_0071410 in the activated human hepatic stellate cell induced by irradiation. Chen Y, Yuan B, Wu Z, Dong Y, Zhang L, Zeng Z. Gene. 2017 significantly down-regulated in irradiated HSC compared with normal HSC. qRT-PCR, microarray irradiated hepatic stellate cell (HSC) and normal HSC circWDR77 circRNA homo sapiens WDR77 hsa_circ_0013509 GACAATAGAATTTTACTCTGGGATACCCGCTGTCCCAAGCCAGCATCACAGATTGGCTGCAGTGCGCCTGGCTACCTTCCTACCTCGCTGGCTTGGCATCCTCAGCAAAGTGAAGTCTTTGTCTTTGGTGATGAGAATGGGACAGTCTCCCTTGTGGACACCAAGAGTACAAGCTGTGTCCTGAGCTCAGCTGTACACTCCCAGTGTGTCACTGGGCTGGTGTTCTCCCCACACAGTGTTCCCTTCCTGGCCTCTCTCAGTGAAGACTGCTCACTTGCTGTGCTGGACTCAAGCCTTTCTGAGTT 29042195 Circular RNA WDR77 target FGF-2 to regulate vascular smooth muscle cells proliferation and migration by sponging miR-124. Chen J, Cui L, Yuan J, Zhang Y, Sang H. Biochem Biophys Res Commun. 2017 Expression of circWDR77 in high glucose treatment VSMCs was significantly up-regulated compared to normal group. microarray, qRT-PCR vascular smooth muscle cells circWDR77 regulated VSMCs proliferation and migration via targeting miR-124/FGF2. loss of function vascular smooth muscle cells miR-124 circRNA-miRNA vascular smooth muscle cells Luciferase reporter assay, RIP circWDR77 was targeted by miR-124 and represented opposite expression, suggesting the molecular sponge role of circWDR77 on miR-124. FGF2 hsa_circ_0013958 circRNA homo sapiens ACP6 hsa_circ_0013958 GTAGAGTGGAACCCCCAGCTATTAGAGGTCCCACCCCAAACTCAGTTTGATTACACAGTCACCAATCTAGCTGGTGGTCCGAAACCATATTCTCCTTACGACTCTCAATACCATGAGACCACCCTGAAGGGGGGCATGTTTGCTGGGCAGCTGACCAAGGTGGGCATGCAGCAAATGTTTGCCTTGGGAGAGAGACTGAGGAAGAACTATGTGGAAGACATTCCCTTTCTTTCACCAACCTTCAACCCACAGGAGGTCTTTATTCGTTCCACTAACATTTTTCGGAATCTGGAGTCCACCCGTTGTTTGCTGGCTGGGCTTTTCCAGTGTCAGAAAGAAG lung adenocarcinoma 28685964 hsa_circ_0013958: a circular RNA and potential novel biomarker for lung adenocarcinoma. Zhu X, Wang X, Wei S, Chen Y, Chen Y, Fan X, Han S, Wu G. FEBS J. 2017 Hsa_circ_0013958 level was up-regulated in LAC microarray, qRT-PCR, FISH primary LAC and noncancer tissues£¬ plasma samples from LAC patients and healthy volunteers£¬ A549 and H1299 Knockdown of hsa_circ_0013958 suppressed proliferation in LAC cells. Induction of cell apoptosis was observed after silencing hsa_circ_0013958 in LAC cells. Hsa_circ_0013958 promoted cell migration and invasion in LAC cells. gain of function, loss of function A549 and H1299 miR-134 circRNA-miRNA HEK293T luciferase reporter assay Compared to the control RNA, only miR-134-5p reduced the luciferase reporter activity by at least 50%. CCND1 hsa_circ_0014130 circRNA homo sapiens PIP5K1A hsa_circ_0014130 AACCTCAACCAGAACCCTCGGACTTTGCTGCCTAAATTCTATGGACTGTACTGTGTGCAGGCAGGTGGCAAGAACATTCGGATTGTGGTGATGAACAATCTTTTACCAAGATCGGTAAAAATGCATATCAAATATGACCTCAAAGGCTCAACCTACAAACGGCGGGCTTCCCAGAAAGAGCGAGAGAAGCCTCTTCCCACATTTAAAGACCTAGACTTCTTACAAGACATCCCTGATGGTCTTTTTTTGGATGCTGACATGTACAACGCTCTCTGTAAGACCCTGCAGCGTGACTGTTTGGTGCTGCAGAGCTTCAAGATAATGGATTACAGCCTCTTGATGTCAATCCATAATATAGATCATGCACAACGAGAGCCCTTAAGCAGTGAAACACAGTACTCAGTTGATACTCGAAGACCGGCCCCCCAAAAGGCTCTGTATTCCACAGCCATGGAATCCATCCAGGGAGAGGCTCGACGGGGTGGTACCATGGAGACTGATGACCATATGGGTGGCATCCCTGCCCGGAATAGTAAAGGGGAAAGGCTTCTGCTTTATATTGGCATCATTGACATTCTACAGTCTTACAGGTTTGTTAAGAAGTTGGAGCACTCTTGGAAAGCCCTGGTACATGACGGAGACACTGTCTCAGTGCATCGCCCAGGCTTCTACGCTGAACGGTTCCAGCGCTTCATGTGCAACACAGTATTTAAGAAGATTCCCT Non-small cell lung cancer (NSCLC) 29440731 Microarray profile of circular RNAs identifies hsa_circ_0014130 as a new circular RNA biomarker in non-small cell lung cancer. Zhang S, Zeng X, Ding T, Guo L, Li Y, Ou S, Yuan H. Sci Rep. 2018 downregulated microarray, qRT-PCR NSCLC tissues and the corresponding adjacent non-cancerous tissues The area under curve was 0.878. NSCLC tissues and the corresponding adjacent non-cancerous tissues miR-892a, miR-216a-3p, miR-302c-3p, miR-493-5p, miR-200c-5p circRNA-miRNA predicted hsa_circ_0014717 circRNA homo sapiens CCT3 hsa_circ_0014717 ACTATTGCAGATATCATCCGAACATGTTTGGGACCCAAGTCCATGATGAAGATGCTTTTGGACCCAATGGGAGGCATTGTGATGACCAATGATGGCAATGCCATTCTTCGAGAGATTCAAGTCCAGCATCCAGCGGCCAAGTCCATGATCGAAATTAGCCGGACCCAGGATGAAGAGGTTGGAGATGGGACCACATCAGTAATTATTCTTGCAGGGGAAATGCTGTCTGTAGCTGAGCACTTCCTGGAGCAGCAGATGCACCCAACAGTGGTGATCAGTGCTTACCGCAAGGCATTGGATGATATGATCAGCACCCTAAAGAAAATAAGTATCCCAGTCGACATCAGTGACAGTGATATGATGCTGAACATCATCAACAGCTCTATTACTACCAAAGCCATCAGTCGGTGGTCATCTTTGGCTTGCAACATTGCCCTGGATGCTGTCAAGATGGTACAGTTTGAGGAGAATGGTCGGAAAGAGATTGACATAAAAAAATATGCAAGAGTGGAAAAG Colorectal cancer 29571246 Hsa_circ_0014717 is downregulated in colorectal cancer and inhibits tumor growth by promoting p16 expression. Wang F, Wang J, Cao X, Xu L, Chen L. Biomed Pharmacother. 2018 Hsa_circ_0014717 was downregulated in CRC qRT-PCR cancer tissues and pair-matched adjacent normal tissues, HCT116, HT29 and SW480 Reduced expression of hsa_circ_0014717 might be associated with the progression, deterioration and poor prognosis of CRC. Hsa_circ_0014717 could inhibit CRC cell proliferation and colony formation, as well as induce cell cycle arrest at G0/G1 phase. Hsa_circ_0014717 could suppress tumorigenesis of CRC cells in vivo. gain of function HT29, HCT116 6-week-old BALB/c athymic nude mice cancer tissues and pair-matched adjacent normal tissues hsa_circ_0014717 circRNA homo sapiens CCT3 hsa_circ_0014717 ACTATTGCAGATATCATCCGAACATGTTTGGGACCCAAGTCCATGATGAAGATGCTTTTGGACCCAATGGGAGGCATTGTGATGACCAATGATGGCAATGCCATTCTTCGAGAGATTCAAGTCCAGCATCCAGCGGCCAAGTCCATGATCGAAATTAGCCGGACCCAGGATGAAGAGGTTGGAGATGGGACCACATCAGTAATTATTCTTGCAGGGGAAATGCTGTCTGTAGCTGAGCACTTCCTGGAGCAGCAGATGCACCCAACAGTGGTGATCAGTGCTTACCGCAAGGCATTGGATGATATGATCAGCACCCTAAAGAAAATAAGTATCCCAGTCGACATCAGTGACAGTGATATGATGCTGAACATCATCAACAGCTCTATTACTACCAAAGCCATCAGTCGGTGGTCATCTTTGGCTTGCAACATTGCCCTGGATGCTGTCAAGATGGTACAGTTTGAGGAGAATGGTCGGAAAGAGATTGACATAAAAAAATATGCAAGAGTGGAAAAG gastric cancer 28544609 Global circular RNA expression profile of human gastric cancer and its clinical significance. Shao Y, Li J, Lu R, Li T, Yang Y, Xiao B, Guo J. Cancer Med. 2017 Expression of hsa_circ_0014718 was downregulated in gastric cancer tissues microarray, qRT-PCR Gastric cancer tissues and their matched adjacent nontumorous tissues hsa_circRNA_100395 circRNA homo sapiens KLHL20 hsa_circ_0015278 TTGGTGGTTGGTGCAGTGGAGATGCCATTTCCAGTGTTGAACGATATGATCCACAGACCAATGAATGGAGAATGGTGGCTTCAATGAGCAAAAGGAGATGCGGAGTTGGGGTCAGTGTTCTTGATGATCTGTTATATGCAGTAGGAGGCCATGATGGATCCTCTTATCTCAATAGTGTTGAAAGGTATGACCCCAAAACAAACCAGTGGAGCAGTGATGTGGCCCCTACAAGCACCTGCAGGACAAGTGTTGGTGTAGCAGTACTTGGAGGCTTTCTTTATGCTGTGGGTGGCCAGGATGGTGTGTCTTGCCTCAACATTGTTGAGAGGTATGATCCGAAGGAGAACAAGTGGACTCGGGTAGCTTCTATGAGTACCAGAAGACTAGGTGTGGCTGTGGCTGTGTTAGGAGGGTTCTTATATGCTGTAGGTGGCTCTGACGGGACATCTCCTCTCAACACAGTGGAACGTTACAATCCTCAGGAAAACAGATGGCACACTATAGCCCCTATGGGGACCCGGAGGAAACACCTAGGCTGTGCAGTATATCAGGACATGATCTATGCTGTAGGAGGTAGAGATGACACTACAGAGCTGAGCAGTGCTGAGAGATACAACCCCAGAACCAACCAGTGGTCTCCAGTGGTGGCCATGACATCACGCCGTAGTGGA papillary thyroid carcinoma 28288173 Microarray profiling of circular RNAs in human papillary thyroid carcinoma. Peng N, Shi L, Zhang Q, Hu Y, Wang N, Ye H. PLoS One. 2017 downregulated microarray, qRT-PCR PTC tumors, matching contralateral normal samples, benign thyroid lesions (i.e., follicular adenoma samples and multinodular goiter samples) hsa-miR-141-3p, hsa-miR-588, hsa-miR-660-3p, hsa-miR-136-5p, hsa-miR-200a-3p circRNA-miRNA predicted hsa_circ_001640 circRNA homo sapiens GLS hsa_circ_0001085 hsa_circ_001640 ATGTGTTCAGAGCAACATTGTTTTGTTGACACAAGCATTTAGAAGAAAGTTTGTGATTCCTGACTTTATGTCTTTTACCTCACACATTGATGAGTTATATGAAAGTGCTAAAAAGCAGTCTGGAGGAAAGGTTGCAGATTATATTCCTCAACTGGCCAAATTCAGTCCCGATTTGTGGGGTGTGTCTGTTTGTACAGTAGATGGACAGAGGCATTCTACTGGAGATACCAAAGTTCCCTTCTGTCTTCAGTCCTGTGTAAAACCTTTGAAATATGCCATTGCTGTTAATGATCTTGGAACTGAATATGTGCATCGATATGTTGGAAAAGAGCCGAGTGGACTAAGATTCAACAAACTATTTTTGAATGAAGATGATAAACCACATAATCCTATGGTAAATGCTGGAGCAATTGTTGTGACTTCACTAATAAAGCAAGGAGTAAATAATGCTGAAAAATTTGACTATGTCATGCAGTTTTTGAATAAGATGGCTGGTAATGAATATGTTGGATTCAGTAATGCAACGTTTCAGTCTGAAAGAGAAAGTGGAGATCGAAATTTTGCAATAGGATATTACTTAAAAGAAAAGAAGTGTTTTCCAGAAGGCACAGACATGGTTGGTATATTAGACTTCTACTTCCAG lung adenocarcinoma 29241190 CircRNA Expression Profile in Early-Stage Lung Adenocarcinoma Patients. Zhao J, Li L, Wang Q, Han H, Zhan Q, Xu M. Cell Physiol Biochem. 2017 down-regulated in lung cancer microarray, qRT-PCR tumors and paired adjacent normal tissue from non-smoking patients with lung adenocarcinoma, A549, H1299, BEAS-2B, B2B miR-6868-3p, miR-942-5p circRNA-miRNA predicted hsa_circ_0017076 circRNA homo sapiens GNG4 hsa_circ_0017076 GTGACCTCAAAGCAGAAGCTCTGAATTCACCTCTCATCTGACGACTGACAGCTGCTGCCACCGCCAGCCTCTGTCCCTTGCCCAGGCCTGTCACACGGCTGCCTCTCAGCAGGGGCAGTAGAATGAAAGAGGGCATGTCTAATAACAGCACCACTAGCATCTCCCAAGCCAGGAAAGCTGTGGAGCAGCTAAAGATGGAAGCCTGTATGGACAGGGTCAAG osteosarcoma 29229385 Circular RNA hsa_circ_0001564 regulates osteosarcoma proliferation and apoptosis by acting miRNA sponge. Song YZ, Li JF. Biochem Biophys Res Commun. 2018 upregulated microarray, qRT-PCR OS tissues and adjacent non-tumor tissues, NHOst, MG63, Saos-2, HOS, and U2OS hsa_circ_0017446 circRNA homo sapiens WDR37 hsa_circ_0017446 TACGTAGAGAAATCGACACTCTTAATGAACGTTTAGCTGCTGAAGGACAAGCGATTGATGGAGCAGAGCTGAGTAAGGGCCAACTCAAAACAAAAGCCAGTCACAGCACCAGCCAGCTCTCCCAGAAACTGAAGACCACTTACAAGGCTTCCACCAGCAAGATTGTCTCCAGCTTTAAGACCACGACATCGAGAGCTGCCTGCCAGCTCGTGAAGGAGTACATCGGCCACCGGGACGGCATCTGGGATGTCAGCGTGGCCAAGACACAGCCAGTGGTGCTCGGGACTGCATCAGCCGATCACACGGCTTTGCTGTGGAGCATAGAGACAGGGAAGTGCCTAGTCAAGTACGCAGGCCACGTGGGCTCAG Acute myeloid leukemia 28282919 Characterization of hsa_circ_0004277 as a New Biomarker for Acute Myeloid Leukemia via Circular RNA Profile and Bioinformatics Analysis. Li W, Zhong C, Jiao J, Li P, Cui B, Ji C, Ma D. Int J Mol Sci. 2017 downregulated microarray, qRT-PCR BM samples from 113 AML patients and 12 healthy controls hsa_circ_0017515 circRNA homo sapiens KLF6 hsa_circ_0017515 ACCTGCCTAGAGCTGGAACGTTACCTCCAGAGCGAGCCCTGCTATGTTTCAGCCTCAGAAATCAAATTTGACAGCCAGGAAGATCTGTGGACCAAAATCATTCTGGCTCGGGAGAAAAAGGAGGAATCCGAACTGAAGATATCTTCCAGTCCTCCAGAGGACACTCTCATCAGCCCGAGCTTTTGTTACAACTTAGAGACCAACAGCCTGAACTCAGATGTCAGCAGCGAATCCTCTGACAGCTCCGAGGAACTTTCTCCCACGGCCAAGTTTACCTCCGACCCCATTGGCGAAGTTTTGGTCAGCTCGGGAAAATTGAGCTCCTCTGTCACCTCCACGCCTCCATCTTCTCCGGAACTGAGCAGGGAACCTTCTCAACTGTGGGGTTGCGTGCCCGGGGAGCTGCCCTCGCCAGGGAAGGTGCGCAGCGGGACTTCGGGGAAGCCAGGTGACAAGGGAAATGGCGATGCCTCCCCCGACGGCAGGAGGAGGGTGCACCGGTGCCACTTTAACGGCTGCAGGAAAGTTTACACCAAAAGCTCCCACTTGAAAGCACACCAGCGGACGCACACAGGAGAAAAGCCTTACAGATGCTCATGGGAAGGGTGTGAGTGGCGTTTTGCAAGAAGTGATGAGTTAACCAGGCACTTCCGAAAGCACACCGGGGCCAAGCCTTTTAAATGCTCCCACTGTGACAGGTGTTTTTCCAGGTCTGACCACCTGGCCCTGCACATGAAGAGGCACCTCTGAGGGAGCAGAGAGGTGGATCCTGTAGGCTAAAAGGCTTCCAGGCTGAGAGCCGGCCGTGGAAGGAGGGATGCGTGTTCCAGCCAAAGCATGCCGTTCTGCACCCTACCCAGTTGCCTCCAGGGCCTCTCCTTGGAAGGTCTTTTGAGGGCTAAAAAGGTCCTGTAAGAAGCGGCATAGCACCCGTGGTGCATGGTATGTGGGTGACCCTGGACTCGCCACTGGTACCCGCCCTTCCGAGCGGCGCCTAAGCCTTTGCCGTGAGCATGCACACTGAGAATGCTAATGGTTGGGTTGATTGTATGTTGAGGATCTATTACTGACCGTATGATGAGGCCAACTTTTTTTCCTTGTGGTTAGCAAGACTGCAAGAGATGGAAAAAAAGTAGTTTGAATGTTTTGTGTGTAAGGAGTATACCATGAGATGAGATGACCACCAATCATTTCCTTGGGGGGAGGGGGTGTCTGCACCTTAGAAAAAAAAAGAAAAATCAAAAAAACAAAAAAACAAAAACAAAAAAAGAAGGAAAATCTTGGAGGGTGGGCGTGGGAACTCAGGACCCCAGAGTGGCGAGTGGTGTGGGGAGGGAGAGCCTCTCTCCCCCTTTTCTGTGTGAGAGGAACTCTTAGTGTCTGGTGCAGCTATTAAATGTGCAATGTGTCAAGTAGCTTGTTTTACACGCTACAACATAGCTCATTTGTAACCCATTGTATAAGCTGTGTATTTACAAATATAACACAACAATTTAACTTTTCCTTAGAATACAAAAAGTCATGCATGGTCTGGGGAACTATATGCTTTTCCATTTTTAAGTCAGGACTGCAATACTGATTCCAGTTAATGAGCAGCTAAGATCCAATCTGTCTAATACAGTGACCCCCTAGCCATCCGGGCCTGGCAATATACAATTTTTTTTCCCCTCCAAGTTTGTAACACTCCCCTTCCAGAAAGGCATTGTGCAACACAGGATTATTTTTAAATGATTCTGAATTTGAATTAACTTTTTGGAGAATTCTGTGATGCCCTTAGAAGAAATTGGACACGTATTGAGTGTCACAAAGCTGGGGCTGGGAATTGCTGGTCTAATGTTTCATTAGACTTAAGAACCTAAAATTTTTCTCAGTTGGGTGGATAAAACCACTAACGCTTAGAAACTGTTTTCTCATGCAGCTATGTTTCTCTTATTTATGCCTTGAGGACTAATTTCTGGTTTTCTAGCTGTTAATGCACTGTTGACCTTCATAATGGTGCCTTACGCAAGCGATCCCTTCTGTGGGGGTCTCATACAGGGGTGTGGGCGATGCATGCTTTATTAAGGCTCTTGTTTCACCTGGCAGTGTACTGTATCAACGTATAATACAGAAAAAAAATCTCTTTAAGGTCCTCCTTCACAAAGACATAGAGTGAAACTCCCTTTACATGTCAGTATTTGTTCAACACTTTAGGCAACTTGACTGTCAGTGTTAAAATGGAAAACAGGAAAATGGAAAAATCTGACCAATTCTGCCACCTTGAGACTTTCATATAGACCTTGCACAACAATTGTATAGATCACACACCGGCTGTATTTAATATGTAACATTTTCACACATATTAAAGATACAGAAGTATTAAAAAACCCCCAATGTTAATGTATTTGCTTAAAAGGCACAAGTTTCACATATCTGTCTAGCTATCTGTTGGTAATACAGAAAGTATACTACTTTTTTAAAAAAGTGGGCAGAATTCTTGTGTATGTATATTTGTGTGTACAGTATGTGTATGTGTGTATATATATATATTATATATATAGATAATATATAAATATTTTTTTTAAGGAGAAACTAGAATGTTTAGCTAGAAAATTCCACAGCCTGTGAAGAAATATTTCAAAATGGCCATAAAGGAGGTAAAAATGAAAACCATAACCTAACTTTTATAGAGGCTTTATCTTTAATTTAACGATGTGCGGAGGACTTTCTTGCTTGAATCTGTTCCGGGCTGTCTGCTCTGTCCATCAAATGGGCAGGTCTGGAATGGGGCACCTTCGGCCGTTCAGAAGTGGCCTGAACAGAATGCTGGAACCCAGGCTGGACTCGGACACACTAAGGTTTTGATTTTGAATTTCAGCCTTATTAGAAGATCTAACCTAAGAGTAAGCTAACCACAGGGATTCTTTTGTAGAACACTTTTTATGCAGATGAAGCTATTTTTTCCAGCAAGTAGATTCTTCCAGTTTTTCCAAGGAGTAATTTCCCCGAATTGGCATACCACGGCGTGGACAGCTGATATTTCACCCAGCTGCTGGCTTGTGGGTGTGGCTCTTTGCTTTATATATATATACACACATGTGAGTCTGGCTGGGCTGGTATTTTGTTTGATCTTCCTGGAAATGAGCAGTGACTAACGCTCACATAACTGGTTTTTTTTTTATCTGGGCTGATGAATACATTTACCTAAGAAACTCATTTCGTTTTACTTAAGAGGGGAAGTGCAGTTTTCTTTTGGCAGTTCAGAATCCAAGCACTTGATTTGCTGGGTTTGGAAAACTCCTTTTTTGGCCTTCTATGTGCTTAGCCATAACAATTCCATTAAGCAAGAAGGTAAGCAAAAGACAAAAAAAAAAAAAGGAAAAAAAAAAACTTGCACTGGCTTGTCTCACTTACGAAACATGTCGGAGCTGTTTGCCTGGGTGGGGCTGGGTACCGTACCTGTCAATGCCTGTGATTTTCATAATTAGCACGTACATAAAGAAGTACATTCTGTTCAGGTGATAACTGAGCCTCAATCAAGCAGAAACTTTTTGCTTGAAATTAAAAAAAAATTTCTATTAGTGAAATTTCTTTTTTTTTTTTTTTTGGAAGCACCCTGTTATCTAAAGAATCTTTGTAAGATTTTTGTAAAATTTTGTTTTACAAGATTTTATTTGAAATTGTTTTTTGCAAGATTGTTATATTTCTGTATGAATGTATTTTTTATTGGAATAACATAAAAGAATTCTTATCAGCATCTTGAGTCTGGTTGTTTTTTTTGGGGGAAGGGGGTTGTTGGAACAGATTCCTCCTGCATTCATCACCCTGGCTTCCTCCTGGGGGCAAATCTTCATTGAGCAACCCTGAGAACAACTCACCGACCTCAGCCCCTTCCTCTTTCCACAGCCTGTCCTGGGAGCTGGAGAGGATGTCAGCGAGCCTGACATTGCCCTCCCTGAATGCATCAAATACTCTTCTCCAAGGACTGACAAAAACAACCCCCCGGCTGTGGGCACAGTAGGGAACCATGCCGGTTTGATCTTCCATTGCTCAAGCCAGGGAATGCATTGCAGAGGCACCTGCACAACGACAAACTTGAGTGTTTCCCTGCCACTTCTGTGCCTCCACAGCCTGCTCCAGTTCCGCAGCTAGAGCTGGGCCTACCTTCCCCAGCCAGCCCTGCCACACACCTGGCTGAGGCATGTCTGGGAGGGGTGGAGGAGGCAGAGGGACTCCAGGCCAGAGGGCTGTTCTCACAACCTCAGCCCACTCTCAGTCAAGGAGGGCAGAAAATAAAAGATGACATCACTGCCA hepatoblastoma 29414822 Expression Profiling Identifies Circular RNA Signature in Hepatoblastoma. Liu BH, Zhang BB, Liu XQ, Zheng S, Dong KR, Dong R. Cell Physiol Biochem. 2018 up microarray, qRT-PCR hepatoblastoma and adjacent normal liver samples hsa_circ_0018289 circRNA homo sapiens SYT15 hsa_circ_0018289 AGCAGCTGGCCCTGGTGATTGGGGGCACCATCGGGGGGCTGCTGCTGCTGCTGTTGATCGGGGCAAGCTGCTGTCTGTGGAGAAGGTTCTGTGCCACCCTCACCTATGAGGAGCTGCCTGGGACACCAGCCATGGCCACCACAGCTGCCTCCAGTGGGCAGCGGGACAGGCCCTGCCAGCCGCATGCTAGGACCCAACTGAGCAGGCCACCAGCTGTGCCATTCGTGGTGCCCCCAACCCTTCAAGGCCGAGATTGGGTGCCCCTGCACAGTGGAGAGTGGGCCGATGCCCCATGGGACCCCTGCCCGGCATCAGAGCTGCTGCCTCACACCTCCAGCGGCGGCCTTG cervical cancer 29156822 Circular RNA expression profiles reveal that hsa_circ_0018289 is up-regulated in cervical cancer and promotes the tumorigenesis. Gao YL, Zhang MY, Xu B, Han LJ, Lan SF, Chen J, Dong YJ, Cao LL. Oncotarget. 2017 hsa_circ_0018289 expression was upregulated in cervical cancer microarray, qRT-PCR pairs of cervical cancer tissue and adjacent noncancerous tissue, HeLa, CaSki, SiHa, HT-3, C33A, HaCaT hsa_circ_0018289 knockdown inhibited the proliferation, migration and invasion of cervical cancer cells in vitro and in vivo loss of function HeLa, SiHa male BALB/c nude mice (6 weeks) miR-497 circRNA-miRNA HEK293T luciferase reporter assay The decreasing of luciferase intensity when hsa_circ_0018289 vector combined with miR-497. hsa_circ_0018293 circRNA homo sapiens None hsa_circ_0018293 GGCTTAGGAACCAAGGAGGGTGTCATCATTGAGATCCTGGCCTCTCGGACCAAGAACCAGCTGCGGGAGATAATGAAGGCGTATGAGGAAGGTAAGGGGTGGCACAGATGGAGGGGCTCAGGAGTGGCCACAAGCTTTGGCAGCCTGGCAGGGAACAAGGATCAAGAATTAACCTGGGCCACACTAGAAAGGACCCTTTGGGGACTTTTTTACCCACAGGTGCTGAGCACCTACCGTATGCCAAGATCTGTGCCTGATGGTGACACTGAACATGATTCAGACTTGATCTGTAAGCTCACCAGCTCCTCTTACAGGGGAGAGAGGCCTGTGACCAACTAAAATCTCTGCCCTTGAGGACTGTGGTAGTAGGGGGTGTGGACCCCAGGCTAGCAGAGGCCAGTCAGTCCTCCACATCATGTACCTAGTGGGGAGTTTTCCTGGAGGCTTTGGCTTTGCCAAGCCTTGAGATGAAATGGAGCTTGGTTGGCAGCCCCTAGCCTGGCTCTCTGACCTGGTCCATCTTGTGCTTTGAGCTTGGTTGGGTACGCATGTCGCTTCTAGTTGTGAAGCACCACCCAGGCGACAGCCACTTGGACACCCGGGCATTGCATCCATGCCCTGTGCCAAGGACTTTCTTTCCTAGAAGGCTTTAATAAGGAGAAGTATGGGGAACAGGGCTGGAAGGAGGAAAGCAGGCCCCGGGTAGGCTGTGGGCCTCTGCTTGTGCCTCATGGTCCTGTTTCCCTGCAGACTATGGGTCCAGCCTGGAGGAGGACATCCAAGCAGACACAAGTGGCTACCTGGAGAGGATCCTGGTGTGCCTCCTGCAGGTGTCACAGCCTAGGCTCTTGGGAGTGCCTTGGTTTGGGAGTCCCAACAGCTCCACCCCAGGGAGCAGCCCTTGAATAGCGCCACAAGAGTCAGGGTAGGGGCATGGGATAGCCCAGCAGCCAGGGCTCATTGGGTGTGTCTCAGCATGGTTAGAGGGTCCCAACTGCAGAGCCCCCACACCTGTCCTTACTCAGCCATGTGAGAGCATCCTGGAAGCGGGAGGAGAGCAGGTCCTTCGTGCAGGCCTCATGCCAGGCACTTTGCTTACCTTAGCTCACTGAATCCGCCAAGCCTTATGAGGCAGTCCTTACCACCCCCATTGTACAAATGAGGAAACCAAGGGCTGAAGAGAATAACTGGCTTGTCGAAGTTTCCACAGCCAAAGAGCAGCAGAGCCATGCCTGCCCTCCAAGCCCAGGATCCCCCCTGTGCCCTTAATGCTCTGGTCAGCTGGCCTGCCTTACAGAGCCACCTCCTCTGTTCCTAGGGCAGCAGGGATGATGTGAGCAGCTTTGTGGACCCAGGACTGGCCCTCCAAGACGCACAGGTGAGGCTGCGCCCAGCCGGCCATGTGGCCCCACCCCCTGCCATCTGGACTCCGGCTCCTCTGCCCACGGGGGCTTTCTCTGACACTGGGCTGGGACCCACCCAGCTCAGCTCCCTATAGGCCTTTGTCCTGTGGTGTCTGGGGAGGAGAGTGAGGGTGTTGGGAGACTCGGGAGGAAGGAGTGTGACTTGGGGGTGGGGGAGCACTAAAGCTCTGTCCTGGCAGGAACAGCCCATGAACCCGGGGGCGCTAGGCCCCAGTGCTGGACACAGGTGTCCGGGTCTCTGTAGGTCTGCCTGCTGGCAGAGGGAAGTCTGGGGACCAGGCAGTTCCTAGAGCAGCTTGTGGCCCAGGATAGAGAAAATATTCTAAGCCAGAGCTGCTAGAGAAAGGGGAGCTCCCTGTCAGAGACGACCAAGCAGGGGAGCATGCTGGCCTGGCAGAGTGGACAGGGCCAGGCCATGGCCACAGCTCTGGGACTCTGGGGCTCAGTCCCTCACCTCCCTGGTCTCCCTCACTGGCTTATTGTGGGTGTCCCAATGCTAGGATCTGTATGCGGCAGGCGAGAAGATTCGTGGGACTGATGAGATGAAATTCATCACCATCCTGTGCACGCGCAGTGCCACTCACCTGCTGAGAG breast cancer 28744405 Circular RNA circ-ABCB10 promotes breast cancer proliferation and progression through sponging miR-1271. Liang HF, Zhang XZ, Liu BG, Jia GT, Li WL. Am J Cancer Res. 2017 down-regulated in breast cancer microarray, qRT-PCR cancer and adjacent noncancerous tissue hsa_circ_0018508 circRNA homo sapiens DNA2 hsa_circ_0018508 ATTTCAGAAGAAAGTGGTAGCTTCCTTTCCAAGAACAGTTCTGAGCACAGGAATGGATAACCGGTACCTGGTGTTGGCAGTCAATACTGTACAGAACAAAGAGGGAAACTGTGAAAAGCGCCTGGTCATCACTGCTTCACAGTCACTAGAAAATAAAGAACTATGCATCCTTAGGAATGACTGGTGTTCTGTTCCAGTAGAGCCAGGAGATATCATTCATTTGGAGGGAGACTGCACATCTGACACTTGGATAATAGATAAAGATTTTGGATATTTGATTCTGTATCCAGACATGCTGATTTCTGGCACCAGCATAGCCAGTAGTATTCGATGTATGAGAAGAGCTGTCCTGAGTGAAACTTTTAGGAGCTCTGATCCAGCCACACGCCAAATGCTAATTGGTACGGTTCTCCATGAGGTGTTTCAAAAAGCCATAAATAATAGCTTTGCCCCAGAAAAGCTACAAGAACTTGCTTTTCAAACAATTCAAGAAATAAGACATTTGAAGGAAATGTACCGCTTAAATCTAAGTCAAGATGAAATAAAACAAGAAGTAGAGGACTATCTTCCTTCGTTTTGTAAATGGGCAGGAGATTTCATGCATAAAAACACTTCGACTGACTTCCCTCAGATGCAGCTCTCTCTGCCAAGTGATAATAGTAAGGATAATTCAACATGTAACATTGAAGTCGTGAAACCAATGGATATTGAAGAAAGCATTTGGTCCCCTAGGTTTGGATTGAAAGGCAAAATAGATGTTACAGTTGGTGTGAAAATACATCGAGGGTATAAAACAAAATACAAGATAATGCCGCTGGAACTTAAAACTGGCAAAGAATCAAATTCTATTGAACACCGTAGTCAGGTTGTTCTGTACACTCTACTAAGCCAAGAGAGAAGAGCTGATCCAGAGGCTGGCTTGCTTCTCTACCTCAAGACTGGTCAGATGTACCCTGTGCCTGCCAACCATCTAGATAAAAGAGAATTATTAAAGCTAAGAAACCAGATGGCATTCTCATTGTTTCACCGTATTAGCAAATCTGCTACTAGACAGAAGACACAGCTTGCTTCTTTGCCACAAATAATTGAGGAAGAGAAAACTTGTAAATATTGTTCACAAATTGGCAATTGTGCTCTTTATAGCAGAGCAGTTGAACAACAGATGGATTGTAGTTCAGTCCCAATTGTGATGCTGCCCAAAATAGAAGAAGAAACCCAGCATCTGAAGCAAACACACTTAGAATATTTCAGCCTTTGGTGTCTAATGTTAACCCTGGAGTCACAATCGAAGGATAATAAAAAGAATCACCAAAATATCTGGCTAATGCCTGCTTCGGAAATGGAGAAGAGTGGCAGTTGCATTGGAAACCTGATTAGAATGGAACATGTAAAGATAGTTTGTGATGGGCAATATTTACATAATTTCCAATGTAAACATGGTGCCATACCTGTCACAAATCTAATGGCAGGTGACAGAGTTATTGTAAGTGGAGAAGAAAGGTCACTGTTTGCTTTGTCTAGAGGATATGTGAAGGAGATTAACATGACAACAGTAACTTGTTTATTAGACAGAAACTTGTCGGTCCTTCCAGAATCAACTTTGTTCAGATTAGACCAAGAAGAAAAAAATTGTGATATAGATACCCCATTAGGAAATCTTTCCAAATTGATGGAAAACACGTTTGTCAGCAAAAAACTTCGAGATTTAATTATTGACTTTCGTGAACCTCAGTTTATATCCTACCTTAGTTCTGTTCTTCCACATGATGCAAAGGATACAGTTGCCTGCATTCTAAAGGGTTTGAATAAGCCTCAGAGGCAAGCGATGAAAAAGGTACTTCTTTCAAAAGACTACACACTCATCGTGGGTATGCCTGGGACAGGAAAAACAACTACGATATGTACTCTCGTAAGAATTCTCTACGCCTGTGGTTTTAGCGTTTTGTTGACCAGCTATACACACTCTGCTGTTGACAATATTCTTTTGAAGTTAGCCAAGTTTAAAATAGGATTTTTGCGTTTGGGTCAGATTCAGAAGGTTCATCCAGCTATCCAGCAATTTACAGAGCAAGAAATTTGCAGATCAAAGTCCATTAAATCCTTAGCTCTTCTAGAAGAACTCTACAATAGTCAACTTATAGTTGCAACAACATGTATGGGAATAAACCATCCAATATTTTCCCGTAAAATTTTTGATTTTTGTATTGTGGATGAAGCCTCTCAAATTAGCCAACCAATTTGTCTGGGCCCCCTTTTTTTTTCACGGAGATTTGTGTTAGTGGGGGACCATCAGCAGCTTCCTCCCCTGGTGCTAAACCGTGAAGCAAGAGCTCTTGGCATGAGTGAAAGCTTATTCAAGAGGCTGGAGCAGAATAAGAGTGCTGTTGTACAGTTAACCGTGCAGTACAGAATGAACAGTAAAATTATGTCCTTAAGTAATAAGCTGACCTATGAGGGCAAGCTGGAGTGTGGATCAGACAAAGTGGCCAATGCAGTGATAAACCTACGTCACTTTAAAGATGTGAAGCTGGAACTGGAATTTTATGCTGACTATTCTGATAATCCTTGGTTGATGGGAGTATTTGAACCCAACAATCCTGTTTGTTTCCTTAATACAGACAAGGTTCCAGCGCCAGAACAAGTTGAAAAAGGTGGTGTGAGCAATGTAACAGAAGCCAAACTCATAGTTTTCCTAACCTCCATTTTTGTTAAGGCTGGATGCAGTCCCTCTGATATTGGTATTATTGCACCGTACAGGCAGCAATTAAAGATCATCAATGATTTATTGGCACGTTCTATTGGGATGGTCGAAGTTAATACAGTAGACAAATACCAAGGAAGGGACAAAAGTATTGTCCTAGTATCTTTTGTTAGAAGTAATAAGGATGGAACTGTTGGTGAACTCTTGAAAGATTGGCGACGTCTTAATGTTGCTATAACCAGAGCCAAACATAAACTGATTCTTCTGGGGTGTGTGCCCTCACTAAATTGCTATCCTCCTTTGGAGAAGCTGCTTAATCATTTAAACTCAGAAAAATTAATCATTGATCTTCCATCAAGAGAACATGAAAGTCTTTGCCACATATTGGGTGACTTTCAAAGAGAATAA type 2 diabetes mellitus 27878383 Hsa_circ_0054633 in peripheral blood can be used as a diagnostic biomarker of pre-diabetes and type 2 diabetes mellitus. Zhao Z, Li X, Jian D, Hao P, Rao L, Li M. Acta Diabetol. 2017 The levels of hsa_circ_0018508 expression in the pre-diabetes and T2DM groups did not differ, but both were higher than that of the control group. qRT-PCR, microarray peripheral blood of T2DM, pre-diabetes and control groups hsa_circ_0019069 circRNA homo sapiens SLC16A12 hsa_circ_0019069 ATGGCGAGTAACCCATGGGCCAGGTAGCGTTCTATGCCAACCTTGAATGCCATCAGGAAGTCACTGGACAGCAAACTCTTCCAAGATCATAACTTGGCTGTTGGAGCAACCTGGAAAAGAAGAAAAAAGAAAAACCATGGCAAAAGTAAATAGAGCTCGGTCTACCTCCCCTCCAGATGGAGGCTGGGGCTGGATGATTGTGGCTGGCTGTTTCCTTGTTACCATCTGCACACGGGCAGTCACAAGATGTATCTCAATTTTTTTTGTGGAGTTCCAGACATACTTCACTCAGGATTACGCACAAACGGCATGGATCCATTCCATTGTAGATTGTGTGACCATGCTCTGTGCTCCACTTGGGAGTGTTGTCAGTAACCATTTATCCTGTCAAGTGGGAATCATGCTGGGTGGCTTGCTTGCATCTACTGGACTCATCCTGAGCTCATTTGCCACGAGTCTGAAGCATCTCTACCTCACTCTGGGAGTTCTTACAGGTCTTGGATTTGCACTTTGTTACTCTCCAGCTATTGCCATGGTTGGCAAGTACTTCAGCAGACGGAAAGCCCTTGCTTATGGTATCGCCATGTCAGGAAGTGGCATTGGCACCTTCATCCTGGCTCCTGTGGTTCAGCTCCTTATTGAACAGTTTTCCTGGCGGGGAGCCTTACTCATTCTTGGGGGCTTTGTCTTGAATCTCTGTGTATGTGGTGCCTTGATGAGGCCAATTACTCTTAAAGAGGACCACACAACTCCAGAGCAGAACCATGTGTGTAGAACTCAGAAAGAAGACATTAAGCGGGTGTCTCCCTATTCATCTTTGACCAAAGAATGGGCACAGACTTGCCTCTGTTGCTGTTTGCAGCAAGAGTACAGTTTTTTACTCATGTCAGACTTTGTTGTGTTAGCCGTCTCCGTTCTGTTTATGGCTTATGGCTGCAGCCCTCTCTTTGTGTACTTGGTGCCTTATGCTTTGAGTGTTGGAGTGAGTCATCAGCAAGCTGCTTTTCTTATGTCCATACTTGGAGTGATTGACATTATTGGCAATATCACATTTGGATGGCTGACCGACAGAAGGTGTCTGAAGAATTACCAGTATGTTTGCTACCTCTTTGCCGTGGGAATGGATGGGCTCTGCTATCTCTGCCTCCCAATGCTTCAAAGTCTCCCTCTGCTCGTGCCTTTCTCTTGTACCTTTGGCTACTTTGATGGTGCCTATGTGACTTTGATCCCAGTAGTGACCACAGAGATAGTGGGGACCACCTCTTTGTCATCAGCGCTTGGTGTGGTATACTTCCTTCACGCAGTGCCATACTTGGTGAGCCCACCCATCGCAG Diabetes Retinopathy 29288268 Identification and Characterization of Circular RNAs as a New Class of Putative Biomarkers in Diabetes Retinopathy. Zhang SJ, Chen X, Li CP, Li XM, Liu C, Liu BH, Shan K, Jiang Q, Zhao C, Yan B. Invest Ophthalmol Vis Sci. 2017 Upregulated in diabetic human retinas compared to nodiabetic retinas. microarray, qRT-PCR diabetic human retinas, nodiabetic retinas hsa_circ_001988 circRNA homo sapiens FBXW7 hsa_circ_0001451 hsa_circ_001988 GATTACTTCCTTAGGATAGATTGCCAGAAGTGGAGTTACTGGGTCAGAGGGTATGAACTTATGAACTTTTTTTTTAAATAAATTTTTTGTTCATTTTCTGTCCAGTCATTTGTAAAAAAATTAAAATAATAATGATTATAATTGTTACCTGCTAGAAAACTGTGTCTGAAGGCAAGATTCTGTGATCAGAAAAGTTTGGGAAATACCCAGGGTAAAAAGCCTTTTAATCTGATTTACCTCAGCATTTCCCAAATTAACTGAACACTGAAAATTTTTTTTGATACACTTCTTAAAATTTTGTGGAAGTTTTATATAGGATATAGTCTATGAACTACTGATGTAAAATTAAAATTGTTTTATTTGCTTGAAATATTATGTTTTATTGGTCAAAGGAATTAAACTATAAATCTTCATGCTAAAAATTATTAAAAGGGATTAGTGTTGTTTACTATGGTTTTTGTGCATGTCTTTATAAAGTCTTATAACTTTTAAAATTGAAATGTTCTATATTGTTTACTAAAGAACATTTTAATGCCTTGGTGGCATCAATACTTTTTTGCAATCATTAATGATATTTAGAAAGTAGACATATAACATGAAAGTAGAACATAATATAGATTGTACAAATCTTGTTTTTTACCCTATTTTCCCCTGCAGAATGTGAAAACCTTTGCATCTTCTGATAGTCTAGCCAAGGTCCAAGAAGTAGCAAGCTGGCTTTTGGAAATGAATCAGGAACTGCTCTCTGTGGGCAGCAAAAGACGACGAACTGGAGGCTCTCTGAGAGGTAACCCTTCCTCAAGCCAGGTAGATGAAGAACAGATGAATCGTGTGGTAGAGGAGGAACAGCAACAGCAACTCAGACAACAAGAGGAGGAGCACACTGCAAGGAATGGTGAAGTTGTTGGAGTAGAACCTAGACCTGGAGGCCAAAATGATTCCCAGCAAGGACAGTTGGAAGAAAACAATAATAGATTTATTTCGGTAGATGAGGACTCCTCAGGAAACCAAGAAGAACAAGAGGAAGATGAAGAACATGCTGGTGAACAAGATGAGGAGGATGAGGAGGAGGAGGAGATGGACCAGGAGAGTGACGATTTTGATCAGTCTGATGATAGTAGCAGAGAAGATGAACATACACATACTAACAGTGTCACGAACTCCAGTAGTATTGTGGACCTGCCCGTTCACCAACTCTCCTCCCCATTCTATACAAAAACAACAAAA Colorectal cancer 26884878 Decreased expression of hsa_circ_001988 in colorectal cancer and its clinical significances. Wang X, Zhang Y, Huang L, Zhang J, Pan F, Li B, Yan Y, Jia B, Liu H, Li S, Zheng W. Int J Clin Exp Pathol. 2015 decreased expression of hsa_circ_001988 in colorectal cancer RNA-seq,RT-PCR and sequencing, qRT-PCR matched colorectal cancer tissue and normal colon mucosa The expression of hsa_circ_001988 was significantly correlated with differentiation (P<0.05) and perineural invasion (P<0.05). The area under ROC curve of hsa_circ_001988 was 0.788 (P<0.05). matched colorectal cancer tissue and normal colon mucosa hsa_circ_0020123 circRNA homo sapiens PDZD8 hsa_circ_0020123 GTTGAATTAATAAAAGGAAATTTACAAAGTGTTGGACTTACACTTCGTCTTGTCCAGTCAACTGATGGGTATGCTGGGCACGTCATCATTGAAACTGTGGCTCCAAACTCGCCTGCTGCAATTGCAGATCTTCAGCGGGGAGATCGACTTATCGCCATTGGAGGTGTGAAAATCACATCAACACTGCAAGTGTTGAAGCTTATCAAGCAGGCTGGTGACCGAGTCCTGGTGTACTATGAAAGGCCTGTTGGCCAGAGTAATCAAGGTGCAGTGCTGCAAGATAACTTTGGCCAGTTGGAAGAAAACTTTTTGTCAAGCTCATGCCAATCGGGTTATGAAGAGGAAGCTGCCGGGTTGACAGTAGATACTGAAAGTAGAGAGCTGGATTCTGAATTTGAAGACTTGGCAAGTGATGTCAGAGCACAAAATGAGTTCAAAGATGAGGCACAATCATTAAGTCATAGTCCCAAACGTGTTCCAACAACACTTTCTATTAAACCCCTTGGAGCTATATCACCAGTTTTAAACCGTAAATTAGCTGTAGGAAGTCACCCACTACCACCGAAAATTCAGTCCAAAGATGGAAATAAACCTCCACCCCTAAAAACTTCTGAGATAACAGACCCAGCACAAGTGTCAAAACCAACCCAAGGATCTGCTTTCAAACCACCTGTGCCACCACGACCACAAGCGAAAGTTCCTTTGCCTTCCGCCGATGCTCCAAATCAGGCAGAACCAGATGTTCTCGTTGAAAAGCCAGAGAAGGTGGTGCCACCTCCTCTTGTAGATAAATCTGCTGAAAAGCAAGCAAAAAATGTGGATGCCATAGACGATGCAGCTGCACCTAAGCAATTTTTAGCAAAGCAAGAAGTGGCCAAAGATGTCACTTCAGAAACTTCCTGCCCTACTAAGGACAGTTCGGACGACCGTCAAACATGGGAATCATCAGAAATTCTTTATCGTAATAAGCTAGGAAAATGGACAAGAACCAGAGCATCCTGTTTGTTTGACATAGAAGCCTGTCACAGGTACTTAAACATTGCATTGTGGTGCAGGGATCCTTTCAAGTTGGGAGGTCTCATCTGTTTGGGGCATGTTAGTTTAAAACTTGAAGATGTGGCTTTAGGATGCCTAGCTACATCAAACACGGAATACCTTTCCAAATTGAGACTGGAAGCCCCCTCACCTAAGGCTATAGTCACTAGAACCGCACTACGCAATCTGAGTATGCAAAAGGGATTCAATGACAAATTTTGCTATGGTGACATTACTATTCACTTCAAATATTTGAAAGAAGGAGAATCAGACCACCATGTAGTTACTAACGTAGAAAAAGAAAAAGAACCCCATTTGGTTGAAGAAGTTTCTGTTCTCCCTAAAGAGGAGCAATTTGTTGGACAGATGGGTTTAACAGAAAACAAACACAGTTTTCAGGATACTCAGTTCCAGAACCCAACATGGTGTGACTACTGTAAGAAAAAAGTTTGGACTAAAGCAGCTTCCCAGTGTATGTTTTGTGCTTATGTTTGCCATAAAAAATGTCAAGAAAAGTGTCTAGCTGAGACTTCTGTTTGTGGAGCAACTGATAGGCGAATAGACAGGACACTGAAAAACCTTAGGCTGGAAGGACAGGAAACCCTCTTAGGCCTGCCTCCTCGTGTTGATGCTGAAGCTAGCAAGTCAGTCAATAAAACAACAGGTTTGACAAGGCATATTATCAATACTAGTTCTCGTTTATTAAATTTGCGTCAAGTCTCTAAAACTCGCCTTTCTGAACCAGGAACCGATCTCGTAGAACCTTCACCAAAACACACACCCAACACGTCAGACAACGAAGGCAGTGACACGGAGGTCTGTGGTCCAAACAGTCCTTCTAAACGGGGAAACAGCACAGGAATAAAGTTAGTGAGAAAAGAGGGTGGTCTGGATGACAGTGTTTTCATTGCAGTTAAAGAAATTGGTCGTGATCTGTACAGGGGCTTGCCTACAGAGGAAAGGATCCAGAAACTAGAGTTCATGTTGGATAAGCTACAGAATGAAATTGATCAGGAGTTGGAACACAATAATTCCCTTGTTAGAGAAGAAAAAGAGACAACTGATACAAGGAAAAAATCACTTCTTTCTGCTGCCTTAGCTAAATCAGGTGAAAGGCTACAAGCTCTAACACTTCTTATGATTCACTACAGAGCAGGCATTGAAGATATAGAAACTTTAGAAAGTCTGTCTTTAGACCAGCACTCCAAAAAAATAAGCAAGTACACAGATGATACAGAAGAAGACCTTGATAATGAAATAAGCCAACTAATAGACTCTCAGCCATTCAGCAGCATATCAGATGACTTATTTGGCCCATCCGAGTCTGTGTAGCAGACAGGTCTATTTAAGCTTTCAAATGAACAGGGTAAAGTTGCATCTAAAGTACCACAGATACAACCATGTTTAAATCCTCGTATGCACTCTGGCCTGCTTCTCCAGTTACTTGCTTGTGTAAGAACAAAAATGAGAAAGGTTGTTTTCCAGTAAAAACATGACCAGCTTAC Non-small cell lung cancer 29372377 Microarray profiles reveal that circular RNA hsa_circ_0007385 functions as an oncogene in non-small cell lung cancer tumorigenesis. Jiang MM, Mai ZT, Wan SZ, Chi YM, Zhang X, Sun BH, Di QG. J Cancer Res Clin Oncol. 2018 upregulated microarray, qRT-PCR NSCLC tissue and adjacent non-cancerous lung tissue hsa_circ_0020397 circRNA homo sapiens DOCK1 hsa_circ_0020397 CTTTTTATAACTATGATGCCAGAGGAGCGGATGAACTTTCTTTACAGATCGGAGACACTGTGCACATCTTAGAAACATATGAAGGGTGGTACCGAGGTTACACGTTACGAAAAAAGTCTAAGAAGGGTATATTTCCTGCTTCATATATTCATCTTAAAGAAGCGATAGTTGAAGGAAAAGGGCAACATGAAACAGTCATCCCGGGTGACCTCCCCCTCATCCAGGAAGTCACCACGACACTCCGAGAGTGGTCCACCATCTGGAGGCAGCTCTACGTGCAAGATAACAGGGAGATGTTTCGAAGTGTGCGGCACATGATCTATGACCTTATTGAATGGCGATCACAAATTCTTTCTGGAACTCTGCCTCAGGATGAACTCAAAGAACTGAAGAAGAAGGTCACAGCCAAAATTGATTATGGAAACAGAATTCTAGATTTGGACCTGGTGGTTAGAGATGAAGATGGGAATATTTTGGATCCAGAATTAACTAGCACGATTAGTCTCTTCAGAGCTCATGAAATAGCTTCTAAACAAGTGGAGGAAAGGTTACAAGAGGAAAAATCTCAAAAGCAGAACATAGATATTAACAGACAAGCCAAGTTTGCTGCAACCCCTTCTCTGGCCTTGTTTGTGAACCTCAAAAATGTGGTTTGTAAAATAGGAGAAGATGCTGAAGTCCTCATGTCTCTATATGACCCTGTGGAGTCCAAATTCATCAGTGAGAACTACCTGGTTCGCTGGTCCAGTTCAGGATTACCTAAAGACATAGACAGATTACATAATTTGCGAGCCGTGTTTACTGACCTCGGAAGCAAAGACCTGAAAAGGGAGAAAATCAGTTTTGTCTGTCAGATTGTTCGCGTGGGTCGCATGGAGCTGAGGGACAACAACACCAGGAAACTGACCTCGGGGTTGCGGCGACCTTTTGGAGTGGCTGTGATGGATGTAACAGATATAATAAATGGAAAAGTAGATGATGAAGATAAGCAGCATTTCATTCCCTTTCAGCCGGTGGCAGGGGAGAATGACTTCCTTCAGACTGTTATAAACAAAGTCATCGCTGCCAAAGAAGTCAACCACAAGGGGCAGGGTTTGTGGGTAACATTGAAATTACTTCCTGGAGATATCCATCAGATCCGAAAAGAGTTTCCGCATTTAGTGGACAGGACCACAGCTGTGGCTCGAAAAACAGGGTTTCCGGAGATAATCATGCCTGGTGATGTTCGAAATGATATCTATGTAACATTAGTTCAAGGAGATTTTGATAAAGGAAGCAAAACAACAGCGAAGAACGTGGAGGTCACGGTGTCTGTGTACGATGAGGATGGGAAACGATTAGAGCATGTGATTTTCCCGGGTGCTGGTGATGAAGCGATTTCAGAGTACAAATCTGTGATTTACTACCAAGTAAAGCAGCCACGCTGGTTTGAGACTGTTAAGGTGGCCATTCCCATCGAGGACGTTAACCGCAGTCACCTTCGGTTTACCTTCCGCCACAGGTCATCACAGGACTCTAAGGATAAATCTGAGAAAATATTTGCACTAGCATTTGTCAAGCTGATGAGATACGATGGTACCACCCTGCGAGACGGAGAGCACGATCTTATCGTCTATAAGGCCGAAGCAAAGAAGCTGGAAGATGCTGCCACGTACTTGAGTCTGCCCTCCACGAAGGCAGAGTTGGAAGAAAAGGGCCACTCGGCCACCGGCAAGAGCATGCAGAGCCTTGGGAGCTGCACCATTAGCAAGGACTCCTTCCAGATCTCCACGCTCGTGTGCTCCACCAAACTGACTCAGAACGTGGACCTTCTGGGGCTCTTGAAATGGCGCTCCAACACCAGCCTGCTGCAGCAGAACTTGAGGCAGCTGATGAAAGTCGATGGTGGTGAAGTAGTGAAGTTTCTTCAGGACACGTTGGATGCCCTCTTCAACATCATGATGGAGAACTCAGAGAGTGAGACTTTTGACACGTTAGTCTTTGATGCTCTGGTATTTATCATTGGACTGATTGCTGATAGAAAATTTCAGCATTTTAATCCTGTTTTGGAAACTTACATTAAGAAACACTTTAGTGCAACGTTAGCCTACACGAAGTTGACAAAAGTGTTGAAGAACTACGTGGACGGTGCTGAGAAGCCGGGAGTAAATGAGCAGCTGTACAAAGCCATGAAAGCGCTAGAATCCATCTTCAAGTTCATCGTGCGCTCCAGGATCCTGTTCAATCAACTGTATGAAAACAAGGGAGAGGCTGACTTCGTGGAATCTTTGCTGCAGCTCTTCAGGTCCATCAATGACATGATGAGCAGCATGTCAGACCAGACCGTCCGGGTGAAGGGGGCAGCACTGAAATACTTACCAACGATCGTCAACGATGTGAAATTGGTGTTTGATCCCAAAGAGCTCAGCAAAATGTTTACTGAATTCATCCTCAATGTTCCCATGGGCTTGCTGACCATCCAGAAACTCTACTGCTTGATCGAAATCGTCCACAGTGACCTCTTCACACAGCATGACTGCAGAGAGATCCTGCTTCCCATGATGACCGATCAGCTCAAGTACCATCTGGAGAGACAGGAGGACCTGGAGGCCTGCTGTCAGCTGCTCAGCCACATCCTGGAGGTGCTGTACAGGAAGGACGTGGGGCCAACCCAGAGGCACGTCCAGATTATCATGGAGAAACTTCTCCGGACCGTGAACCGAACCGTCATTTCCATGGGACGAGATTCTGAACTCATT Colorectal cancer 28707774 Hsa_circ_0020397 regulates colorectal cancer cell viability, apoptosis and invasion by promoting the expression of the miR-138 targets TERT and PD-L1. Zhang XL, Xu LL, Wang F. Cell Biol Int. 2017 Hsa_circ_0020397 was upregulated in CRC qRT-PCR CCD 841 CoN, LoVo, HCT116, SW480 and SW620 Hsa_circ_0020397 promoted cell viability and invasion of CRC cells and inhibited their apoptosis gain of function HTC116 and LoVo miR-138 circRNA-miRNA HCT116 luciferase reporter assay Using a dual-luciferase reporter assay, we show evidence of miR-138-binding sites on hsa_circ_0020397, and that overexpression of hsa_circ_0020397 could inhibit the downregulation of luciferase activity by miR-138. TERT and PD-L1 hsa_circ_002059 circRNA homo sapiens KIAA0907 hsa_circ_0000140 hsa_circ_002059 ATGCATTATGTTCAAGATAAATTATTTGTGGGTCTAGAACATGCTGTACCCACTTTTAATGTCAAGGAGAAGGTGGAAGGTCCAGGCTGCTCCTATTTGCAGCACATTCAGATTGAAACAGGTGCCAAAGTCTTCCTGCGGGGCAAAGGTTCAGGCTGCATTGAGCCAGCATCTGGCCGAGAAGCTTTTGAACCTATGTATATTTACATCAGTCACCCCAAACCAGAAGGCCTGGCTGCTGCCAAGAAGCTTTGTGAGAATCTTTTGCAAACAGTTCATGCTGAATACTCTAGATTTGTGAATCAGATTAATACTGCTGTACCTTTACCAGGCTATACACAACCCTCTGCTATAAGTAGTGTCCCTCCTCAACCACCATATTATCCATCCAATGGCTATCAGTCTGGTTACCCTGTTGTTCCCCCTCCTCAGCAGCCAGTTCAACCTCCCTACGGAGTACCAAGCATAGTGCCACCAGCTGTTTCATTAGCACCTGGAGTCTTGCCGGCATTACCTACTGGAGTCCCACCTGTGCCAACACAATACCCGATAACACAAGTGCAGCCTCCAGCTAGCACTGGACAG gastric cancer 25689795 Using circular RNA as a novel type of biomarker in the screening of gastric cancer. Li P, Chen S, Chen H, Mo X, Li T, Shao Y, Xiao B, Guo J. Clin Chim Acta. 2015 downregulated in gastric cancer qRT-PCR gastric cancer tissues and paired adjacent nontumorous tissues the area under the ROC curve was 0.73 gastric cancer tissues and paired adjacent nontumorous tissues hsa_circ_0021001 circRNA homo sapiens ARFIP2 hsa_circ_0021001 GGTGCTGGGGTGGAGAGTTTTACTCCAATACCTTTCCTAGCCATGACGGACGGGATCCTAGGGAAGGCAGCCACAATGGAGATCCCTATCCACGGGAACGGCGAAGCCAGGCAGCTTCCTGAAGATGATGGGCTGGAGCAGGACCTCCAGCAGGTGATGGTGTCAGGACCCAACCTCAATGAAACCAGCATTGTGTCTGGTGGCTATGGGGGCTCTGGTGATGGACTCATCCCCACAGGGAAGTCAATTTCATGTGCTCGAAGAGAAGTATGGGTGGGGCCACAGAGGTGTCTGGTGTATCTGAGAGAGGCTGGTGTCAGAGAACTTGATCCTTTAGGGTCTGGCCGCCATCCATCTCACAGCACCACTCCTTCTGGCCCTGGAGATGAGGTGGCTCGGGGCATTGCTGGAGAAAAGTTTGACATCGTCAAGAAATGGGGCATCAACACCTATAAGTGCACAAAGCAACTGTTATCAGAACGATTTGGTCGAGGCTCACGGACTGTGGACCTGGAGCTAGAGCTGCAGATTGAGTTGCTGCGTGAGACGAAGCGCAAGTATGAGAGTGTCCTGCAGCTGGGCCGGGCACTGACAGCCCACCTCTACAGCCTGCTGCAGACCCAGCATGCACTGGGTGATGCCTTTGCTGACCTCAGCCAGAAGTCCCCAGAGCTTCAG intracranial aneurysm 29291016 Circular RNA hsa_circ_0021001 in peripheral blood: a potential novel biomarker in the screening of intracranial aneurysm. Teng L, Chen Y, Chen H, He X, Wang J, Peng Y, Duan H, Li H, Lin D, Shao B. Oncotarget. 2017 Hsa_circ_0021001 level in the peripheral blood of IA patients was relatively lower than that in the control group (P=0.002). The area under ROC (AUC) was 0.87, indicating that hsa_circ_0021001 was highly effective in the diagnosis of IA. In addition, hsa_circ_0021001 expression was correlated with aneurysm rupture, Hunt, Hess level, and timing of surgery (P= 0.041, 0.013, and 0.001, respectively). Patients with high expression of hsa_circ_0021001 had longer disease-free survival (DFS) and overall survival (OS) (P < 0.05). We found for the first time that hsa_circ_0021001 decreased significantly in the peripheral blood of IA patients, which suggested that hsa_circ_0021001 might be used as a potential novel marker for the diagnosis of IA. qRT-PCR Peripheral blood of IA patients and healthy volunteers hsa_circRNA_100777 circRNA homo sapiens MPPED2 hsa_circ_0021553 AAATGCACAGCGGTATTGATGAGTAGATCCTTGGATTCAGAGGTTGGCTGAAACGCACCATGCCTGCTTCCATCTTTTGCTCTGTAAAGTTGTGAATTGCTCATGCCTATAGGGAGGAAGGATGGCACATGGGATTCCTTCTCAAGGCAAAGTTACCATAACGGTGGATGAGTACAGCTCAAACCCCACCCAGGCATTCACGCACTACAACATCAACCAGAGCAGATTCCAGCCTCCACATGTACATATGGTCGACCCCATCCCATATGACACTCCAAAACCAGCGGGCCACACGCGGTTTGTCTGCATCTCAGACACACACTCCAGAACAGATGGTATCCAGATGCCTTATGGGGACATCCTTCTCCACACAGGCGATTTCACCGAGCTGGGACTGCCCTCAGAGGTTAAGAAGTTTAATGACTGGTTAG papillary thyroid carcinoma 28288173 Microarray profiling of circular RNAs in human papillary thyroid carcinoma. Peng N, Shi L, Zhang Q, Hu Y, Wang N, Ye H. PLoS One. 2017 downregulated microarray, qRT-PCR PTC tumors, matching contralateral normal samples, benign thyroid lesions (i.e., follicular adenoma samples and multinodular goiter samples) hsa-miR-122-5p, hsa-miR-574-5p, hsa-miR-493-5p, hsa-miR-380-5p,hsa-miR-92a-2-5p circRNA-miRNA predicted hsa_circ_0023110 circRNA homo sapiens GSTP1 hsa_circ_0023110 TGGGAAAGAGGGAAAGGCTTCCCCGGCCAGCTGCGCGGCGACTCCGGGGACTCCAGGGCGCCCCTCTGCGGCCGACGCCCGGGGTGCAGCGGCCGCCGGGGCTGGGGCCGGCGGGAGTCCGCGGGACCCTCCAGAAGAGCGGCCGGCGCCGTGACTCAGCACTGGGGCGGAGCGGGGCGGGACCACCCTTATAAGGCTCGGAGGCCGCGAGGCCTTCGCTGGAGTTTCGCCGCCGCAGTCTTCGCCACCATGCCGCCCTACACCGTGGTCTATTTCCCAGTTCGAGGCCGCTGCGCGGCCCTGCGCATGCTGCTGGCAGATCAGGGCCAGAGCTGGAAGGAGGAGGTGGTGACCGTGGAGACGTGGCAGGAGGGCTCACTCAAAGCCTCCTGCCTATACGGGCAGCTCCCCAAGTTCCAGGACGGAGACCTCACCCTGTACCAGTCCAATACCATCCTGCGTCACCTGGGCCGCACCCTTGGGCTCTATGGGAAGGACCAGCAGGAGGCAGCCCTGGTGGACATGGTGAATGACGGCGTGGAGGACCTCCGCTGCAAATACATCTCCCTCATCTACACCAACTATGAGGCGGGCAAGGATGACTATGTGAAGGCACTGCCCGGGCAACTGAAGCCTTTTGAGACCCTGCTGTCCCAGAACCAGGGAGGCAAGACCTTCATTGTGGGAGACCAGATCTCCTTCGCTGACTACAACCTGCTGGACTTGCTGCTGATCCATGAGGTCCTAGCCCCTGGCTGCCTGGATGCGTTCCCCCTGCTCTCAGCATATGTGGGGCGCCTCAGTGCCCGGCCCAAGCTCAAGGCCTTCCTGGCCTCCCCTGAGTACGTGAACCTCCCCATCAATGGCAACGGGAAACAGTGAGGGTTGGGGGGACTCTGAGCGGGAGGCAGAGTTTGCCTTCCTTTCTCCAGGACCAATAAAATTTCTAAGAGAGCTA hepatoblastoma 29414822 Expression Profiling Identifies Circular RNA Signature in Hepatoblastoma. Liu BH, Zhang BB, Liu XQ, Zheng S, Dong KR, Dong R. Cell Physiol Biochem. 2018 down microarray, qRT-PCR hepatoblastoma and adjacent normal liver samples hsa_circ_0023114 circRNA homo sapiens GSTP1 hsa_circ_0023114 GCCGCTGCGCGGCCCTGCGCATGCTGCTGGCAGATCAGGGCCAGAGCTGGAAGGAGGAGGTGGTGACCGTGGAGACGTGGCAGGAGGGCTCACTCAAAGCCTCCTGCCTATACGGGCAGCTCCCCAAGTTCCAGGACGGAGACCTCACCCTGTACCAGTCCAATACCATCCTGCGTCACCTGGGCCGCACCCTTG hepatoblastoma 29414822 Expression Profiling Identifies Circular RNA Signature in Hepatoblastoma. Liu BH, Zhang BB, Liu XQ, Zheng S, Dong KR, Dong R. Cell Physiol Biochem. 2018 down microarray, qRT-PCR hepatoblastoma and adjacent normal liver samples hsa_circ_0023117 circRNA homo sapiens GSTP1 hsa_circ_0023117 CTATACGGGCAGCTCCCCAAGTTCCAGGACGGAGACCTCACCCTGTACCAGTCCAATACCATCCTGCGTCACCTGGGCCGCACCCTTGGGCTCTATGGGAAGGACCAGCAGGAGGCAGCCCTGGTGGACATGGTGAATGACGGCGTGGAGGACCTCCGCTGCAAATACATCTCCCTCATCTACACCAACTATGAGGCGGGCAAGGATGACTATGTGAAGGCACTGCCCGGGCAACTGAAGCCTTTTGAGACCCTGCTGTCCCAGAACCAGGGAGGCAAGACCTTCATTGTGGGAGACCAGATCTCCTTCGCTGACTACAACCTGCTGGACTTGCTGCTGATCCATGAGGTCCTAGCCCCTGGCTGCCTGGATGCGTTCCCCCTGCTCTCAGCATATGTGGGGCGCCTCAGTGCCCGGCCCAAGCTCAAGGCCTTCCTGGCCTCCCCTGAGTACGTGAACCTCCCCATCAATGGCAACGGGAAACAGTGAGGGTTGGGGGGACTCTGAGCGGGAGGCAGAGTTTGCCTTCCTTTCTCCAGGACCAATAAAATTTCTAAGAGAGCTA hepatoblastoma 29414822 Expression Profiling Identifies Circular RNA Signature in Hepatoblastoma. Liu BH, Zhang BB, Liu XQ, Zheng S, Dong KR, Dong R. Cell Physiol Biochem. 2018 down microarray, qRT-PCR hepatoblastoma and adjacent normal liver samples circRNA-CER circRNA homo sapiens RNF121 hsa_circ_0023404 circRNA_100876 GTTGATATGTCAGATCTCTCTCCAGAAGAGCAATGGAGGGTCGAGCACGCACGCATGCATGCCAAGCACCGTGGCCATGAAGCTATGCATGCTGAAATGGTCCTCATCCTCATCGCAACCTTGGTGGTGGCCCAGCTGCTCCTGGTGCAGTGGAAGCAGAGGCACCCACGCTCCTACAAT Cartilage Degradation 26931159 Circular RNA Related to the Chondrocyte ECM Regulates MMP13 Expression by Functioning as a MiR-136 Sponge in Human Cartilage Degradation. Liu Q, Zhang X, Hu X, Dai L, Fu X, Zhang J, Ao Y. Sci Rep. 2016 up-regulated in OA with 2.5-fold change by qPCR qRT-PCR osteoarthritis Silencing of circRNA-CER using small interfering RNA suppressed MMP13 expression and increased ECM formation. CircRNA-CER could compete for miR-136 with MMP13. circRNA-CER regulated MMP13 expression by functioning as a competing endogenous RNA (ceRNA) and participated in the process of chondrocyte ECM degradation. loss of function OA chondrocytes miR-136 circRNA-miRNA OA chondrocytes luciferase reporter assay CircRNA-CER is targeted by MMP13-targeting miRNAs. MMP13 hsa_circ_0023642 circRNA homo sapiens UVRAG hsa_circ_0023642 CAAAAGATGATGGAAGCATTGCTGTTGCCCTTGGTTATACTGCACATCTGGTCTCCATGATTTCCTTTTTCCTACAAGTGCCCCTCAGATATCCTATAATTCATAAGGGGTCTAGATCAACAATCAAAGACAATATCAATGACAAACTGACGGAAAAGGAGAGAGA gastric cancer 28737829 Expression profile of circular RNAs in human gastric cancer tissues. Huang YS, Jie N, Zou KJ, Weng Y. Mol Med Rep. 2017 upregulated microarray, qRT-PCR GC tissues and adjacent normal tissues hsa_circ_0023956 circRNA homo sapiens C11orf73 hsa_circ_0023956 GTGCAAACAGCTGCACAGCAAGTGGCAGAGGATAAATTTGTTTTTGACTTACCTGATTATGAAAGTATCAACCATGTTGTGGTTTTTATGCTGGGAACAATCCCATTTCCTGAGGGAATGGGAGGATCTGTCTACTTTTCTTATCCTGATTCAAATGGAATGCCAGTATGGCAACTCCTAGGATTTGTCACGAATGGGAAGCCAAGTGCCATCTTCAAAATTTCAGGTCTTAAATCTG Active Pulmonary Tuberculosis 28846924 The circular RNA of peripheral blood mononuclear cells: Hsa_circ_0005836 as a new diagnostic biomarker and therapeutic target of active pulmonary tuberculosis. Zhuang ZG, Zhang JA, Luo HL, Liu GB, Lu YB, Ge NH, Zheng BY, Li RX, Chen C, Wang X, Liu YQ, Liu FH, Zhou Y, Cai XZ, Chen ZW, Xu JF. Mol Immunol. 2017 significantly decreased in APTB patients compared to HC patients. RNA-seq, qRT-PCR APTB patients, HC patients. hsa_circ_0024108 circRNA homo sapiens MMP1 hsa_circ_0024108 GATTGAAAATTACACGCCAGATTTGCCAAGAGCAGATGTGGACCATGCCATTGAGAAAGCCTTCCAACTCTGGAGTAATGTCACACCTCTGACATTCACCAAGGTCTCTGAGGGTCAAGCAGACATCATGATATCTTTTGTCAGGGGAGATCATCGGGACAACTCTCCTTTTGATGGACCTGGAGGAAATCTTGCTCATGCTTTTCAACCAGGCCCAGGTATTGGAGGGGATGCTCATTTTGATGAAGATGAAAGGTGGACCAACAATTTCAGAGAGTACAACTTACATCGTGTTGCAGCTCATGAACTCGGCCATTCTCTTGGACTCTCCCATTCTACTGATATCGGGGCTTTGATGTACCCTAGCTACACCTTCAGTGGTGATGTTCAGCTAGCTCAGGATGACATTGATGGCATCCAAGCCATATATGGACGTTCCCAAAATCCTGTCCAGCCCATCGGCCCACAAACCCCAAAAGCGTGTGACAGTAAGCTAACCTTTGATGCTATAACTACGATTCGGGGAGAAGTGATGTTCTTTAAAGACAGATTCTACATGCGCACAAATCCCTTCTACCCGGAAGTTGAGCTCAATTTCATTTCTGTTTTCTGGCCACAACTGCCAAATGGGCTTGAAGCTGCTTACGAATTTGCCGACAGAGATGAAGTCCGGTTTTTCAAAGGGAATAAGTACTGGGCTGTTCAGGGACAGAATGTGCTACACGGATACCCCAAGGACATCTACAGCTCCTTTGGCTTCCCTAGAACTGTGAAGCATATCGATGCTGCTCTTTCTGAGGAAAACACTGGAAAAACCTACTTCTTTGTTGCTAACAAATACTGGAGGTATGATGAATATAAACGATCTATGGATCCAGGTTATCCCAAAATGATAGCACATGACTTTCCTGGAATTGGCCACAAAGTTGATGCAGTTTTCATGAAAGATGGATTTTTCTATTTCTTTCATGGAACAAGACAATACAAATTTGATCCTAAAACGAAGAGAATTTTGACTCTCCAGAAAGCTAATAGCTGGTTCAACTGCAGGAAAAATTGAACATTACTAATTTGAATGGAAAACACATGGTGTGAGTCCAAAGAAGGTGTTTTCCTGAAGAACTGTCTATTTTCTCAGTCATTTTTAACCTCTAGAGTCACTGATACACAGAATATAATCTTATTTATACCTCAGTTTGCATATTTTTTTACTATTTAGAATGTAGCCCTTTTTGTACTGATATAATTTAGTTCCACAAATGGTGGGTACAAAAAGTCAAGTTTGTGGCTTATGGATTCATATAGGCCAGAGTTGCAAAGATCTTTTCCAGAGTATGCAACTCTGACGTTGATCCCAGAGAGCAGCTTCAGTGACAAACATATCCTTTCAAGACAGAAAGAGACAGGAGACATGAGTCTTTGCCGGAGGAAAAGCAGCTCAAGAACACATGTGCAGTCACTGGTGTCACCCTGGATAGGCAAGGGATAACTCTTCTAACACAAAATAAGTGTTTTATGTTTGGAATAAAGTCAACCTTGTTTCTACTGTTTTATACACTTTC hypopharyngeal squamous cell carcinoma 28514762 Novel circular RNA expression profiles reflect progression of patients with hypopharyngeal squamous cell carcinoma. Cao S, Wei D, Li X, Zhou J, Li W, Qian Y, Wang Z, Li G, Pan X, Lei D. Oncotarget. 2017 up microarray, qRT-PCR Tumor tissues and paired adjacent normal tissues miR-185-3p, miR-296-3p, miR-623, miR-670-5p circRNA-miRNA Nasopharyngeal carcinoma, Glioblastoma, prostate cancer, Non-small cell lung cancer, Lung adenocarcinoma, Hepatocellular carcinoma validted in other papers (PMID:25297925, 22999387, 26923924, 24263102, 26870998, 27186308, 27685632, 26796260) hsa_circ_0026372 circRNA homo sapiens KRT81 hsa_circ_0026372 GCTATGTGAAGGCATTGGGGCTGTGAATGTCTGTGTCAGCAGCTCCCGGGGCGGGGTCGTGTGCGGGGACCTCTGCGTGTCAGGCTCCCGGCCAGTGACTGGCAGTGTCTGCAGCGCTCCGTGCAACGGGAACGTGGCGGTGAGCACCGGCCTGTGTGCGCCCTGCGGCCAATTGAACACCACCTGCGGAGGGGGTTCCTGCGGCGTGGGCTCCTGTGGTATCAGCTCCCTGGGTGTGGGGTCTTGCGGCAGCAGCTGCCGGAAATGTTAGGCACCCCAACTCAAGTCCCAGGCCCCAGGCATCTTTCCTGCCCTGCCTTGCTTGGCCCATCCAGTCCAGGCGCCTGGAGCAAGTGCTCAGCTACTTCTCCTGCACTTTGAAAGACCCCTCCCACTCCTGGCCTCACATTTCTCTGTGTGATCCCCCACTTCTGGGCTCTGCCACCCCACAGTGGGAAAGGCCACCCTAGAAAGAAGTCCGCTGGCACCCATAGGAAGGGGCCTCAGGAGCAGGAAGGGCCAGGACCAGAACCTTGCCCACGGCAACTGCCTTCCTGCCTCTCCCCTTCCTCCTCTGCTCTTGATCTGTGTTTCAATAAATTAATGTAGCCAA Diabetes Retinopathy 29288268 Identification and Characterization of Circular RNAs as a New Class of Putative Biomarkers in Diabetes Retinopathy. Zhang SJ, Chen X, Li CP, Li XM, Liu C, Liu BH, Shan K, Jiang Q, Zhao C, Yan B. Invest Ophthalmol Vis Sci. 2017 Downregulated in diabetic human retinas compared to nodiabetic retinas. microarray, qRT-PCR diabetic human retinas, nodiabetic retinas hsa_circ_0026388 circRNA homo sapiens KRT75 hsa_circ_0026388 GTGAGGTTCTTGGAGCAGCAGAACAAGGTCCTGGAGACCAAGTGGGCCCTCCTGCAGGAGCAGGGCTCCAGGACTGTGAGGCAGAACCTAGAGCCCCTCTTTGATTCCTATACCAGTGAGCTCCGACGGCAGCTGGAAAGCATCACCACCGAGAGGGGCAGGCTTGAAGCTGAACTGAGGAACATGCAGGATGTTGTGGAAGATTTCAAAGTCAGGTACGAAGATGAAATTAACAAGCGCACAGCTGCTGAGAATGAATTTGTAGCCCTGAAAAAGGACGTAGATGCTGCCTATATGAACAAGGTGGAGCTGGAAGCCAAGGTCAAATCTCTGCCCGAGGAGATCAACTTCATCCACTCAGTCTTTGATGCAGAGCTGTCCCAGTTGCAGACCCAGGTCGGTGACACATCCGTGGTGCTGTCCATGGACAACAACCGCAACCTGGACCTGGATAGTATCATCGCCGAGGTCAAAGCACAATACGAGGACATTGCCAACCGCAGCCGGGCCGAGGCTGAGTCCTGGTACCAGACCAAGTACGAGGAGCTGCAGGTCACCGCAGGCAGACATGGGGATGACCTTCGAAACACCAAACAAGAGATCTCTGAAATGAACCGCATGATCCAGAGGCTGAGAGCTGAGATTGACAGCGTCAAGAAGCAGTGTTCCAGCTTGCAAACGGCCATTGCTGATGCAGAGCAGCGGGGAGAACTGGCTCTCAAGGATGCACGGGCCAAGCTGGTGGACCTTGAGGAGGCCCTGCAGAAGGCCAAGCAGGACATGGCTCGGCTCCTGCGTGAGTACCAGGAGCTGATGAACATCAAGCTGGCCCTGGACGTGGAGATCGCCACCTACCGCAAGCTGCTGGAAGGCGAGGAGTGCAGGTTGAGTGGAGAGGGAGTTTCTCCAGTTAACATTTCTGTGGTCACCTCTACTCTTTCCAGTGGCTATGGAAGCGGCAGCAGCATTGGAGGTGGAAACCTGGGCCTCGGTGGGGGCAGCGGCTACTCCTTCACCACCAGTGGTGGGCATAGCCTGGGTGCAGGCCTGGGAGGTTCTGGATTCAGTGCCACCAGCAACCGGGGCTTAGGGGGCAGTGGTTCTAGCGTCAAGTTTGTCTCCACCACATCCTCCAGCCAGAAGAGCTACACGCACTAAGAGAGCCCCATGGCTCCCTCTACCCTGCCTTGAGGCCTGTTTGCAGTCACACCTGGACACCAGGGTCCTCCTCCTTCCTCTCTCCTTGTAAGGTGCACCTGTGCTGCTGGGAGCCTGGAGTACTGGCTATACCCATTCCCAGGCCTAAGCCAGCCTCTCCCTCCTGACAGTGCCCAGACTGCCAGCAGCACCCGTCTGTTACACATGTGAAACCAAAGCCTGCTCTCTCCTAAGGCTCTCATTCAGCCTATCTTGCGAGGCCCGGGCAGCTGGAAAGTCCTCCTCCAGCTCCACCTCCCTCCCTCCCTCCAGATGCAGAGGCTGGGGAGTCTCTCAATGCCAGGTTGTCACCCACCTGTCTCATAGTGTTTATAAGTGGCCTGCTGGGAGTGAGTGCTCCCTCTGTTCCCTCCCTGGAATGTGTCTATTAAATGCATGTGTCACCTG Diabetes Retinopathy 29288268 Identification and Characterization of Circular RNAs as a New Class of Putative Biomarkers in Diabetes Retinopathy. Zhang SJ, Chen X, Li CP, Li XM, Liu C, Liu BH, Shan K, Jiang Q, Zhao C, Yan B. Invest Ophthalmol Vis Sci. 2017 Downregulated in diabetic human retinas compared to nodiabetic retinas. microarray, qRT-PCR diabetic human retinas, nodiabetic retinas hsa_circ_0030055 circRNA homo sapiens MTRF1 hsa_circ_0030055 ATGCTGAGATGAATCGTCACCTGTGTGTTTGGCTTTTTAGACATCCATCTCTTAATGGTTACCTCCAGTGTCACATCCAGCTCCATTCTCATCAATTTAGACAGATACATCTTGATACAAGGCTGCAAGTTTTTAGACAAAACAGGAATTGCATTCTTCATCTGTTAAGTAAGAATTGGTCCAGGAGATATTGCCATCAAGACACCAAGATGCTCTGGAAGCATAAAGCACTACAGAAATATATGGAGAACCTGAGTAAGGAGTACCAAACACTTGAGCAATGTCTGCAGCATATCCCTGTGAATGAGGAAAACCGAAGGTCCTTGAACAGAAGGCATGCTGAGTTGGCACCTCTTGCAGCCATTTACCAAGAAATTCAGGAGACTGAACAAGCAATTGAAGAATTAGAATCAATGTGTAAAAGCCTAAATAAACAAGATGAAAAGCAGTTACAAGAACTTGCACTGGAAGAAAGGCAAACCATTGATCAAAAAATCAACATGTTGTACAATGAGCTTTTCCAGAGCCTTGTGCCAAAGGAGAAATATGACAAAAATGATGTTATTTTAGAGGTGACAGCTGGAAGGACTACTGGAGGTGACATCTGCCAACAATTTACCCGAGAAATATTTGACATGTACCAGAATTATTCGTGCTATAAACACTGGCAATTTGAACTTCTGAATTATACACCAGCAGATTATGGTGGACTACATCATGCAGCCGCCCGAATTTCCGGTGACGGTGTCTATAAGCATTTGAAGTATGAGGGTGGGATTCACCGAGTTCAGCGCATCCCCGAGGTGGGCCTGTCCTCAAGGATGCAGCGCATTCACACAGGAACGATGTCGGTTATTGTCCTTCCTCAGCCAGATGAGGTGGATGTGAAATTGGACCCCAAGGATTTGCGAATAGATACATTTCGAGCCAAAGGAGCAGGAGGGCAGCATGTTAATAAAACTGATAGTGCCGTCAGACTTGTCCACATCCCCACAGGGCTAGTAGTAGAATGCCAACAAGAAAGATCACAGATAAAAAATAAAGAAATAGCCTTTCGTGTGTTGAGAGCTAGACTCTACCAGCAGATTATTGAGAAAGACAAGCGTCAGCAACAAAGTGCTAGAAAACTGCAGGTGGGAACAAGAGCCCAGTCAGAGCGAATTCGGACATATAATTTCACCCAGGATAGAGTCAGTGACCACAGGATAGCATATGAAGTTCGTGATATTAAG Diabetes Retinopathy 29288268 Identification and Characterization of Circular RNAs as a New Class of Putative Biomarkers in Diabetes Retinopathy. Zhang SJ, Chen X, Li CP, Li XM, Liu C, Liu BH, Shan K, Jiang Q, Zhao C, Yan B. Invest Ophthalmol Vis Sci. 2017 Downregulated in diabetic human retinas compared to nodiabetic retinas. microarray, qRT-PCR diabetic human retinas, nodiabetic retinas CircPABPN1 circRNA homo sapiens PABPN1 hsa_circ_0031288 GTGATCCCAAAACGAACCAACAGACCAGGCATCAGCACAACAGACCGGGGTTTTCCACGAGCCCGCTACCGCGCCCGGACCACCAACTACAACAGCTCCCGCTCTCGATTCTACAGTGGTTTTAACAGCAGGCCCCGGGGTCGCGTCTACAG 28080204 Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1. Abdelmohsen K, Panda AC, Munk R, Grammatikakis I, Dudekula DB, De S, Kim J, Noh JH, Kim KM, Martindale JL, Gorospe M. RNA Biol. 2017 This circRNA originates from Poly(A)-binding protein nuclear 1 (PABPN1) pre-mRNA and thus we named it CircPABPN1. Further analyses included specific CircPABPN1 RT-qPCR amplification, visualization on agarose gels (with no amplification in -RT reactions), and sequencing of the amplified PCR product to verify the specific circRNA junction. Digestion of total RNA with RNase R to degrade linear RNAs followed by RT-qPCR analysis indicated that CircPABPN1 was protected from RNase R digestion, while GAPDH and PABPN1 mRNAs were degraded. qRT-PCR HeLa HuR did not influence CircPABPN1 abundance; interestingly, however, high levels of CircPABPN1 suppressed HuR binding to PABPN1 mRNA. Evaluation of PABPN1 mRNA polysomes indicated that PABPN1 translation was modulated positively by HuR and hence negatively by CircPABPN1. HeLa HuR circRNA-protein HeLa Biotin pull-down assay endogenous HuR can bind to cellular circRNAs and reveal strong binding of CircPABPN1 to HuR, as determined using microarrays and RTqPCR analyses, sequencing of circRNA junctions, and biotinylated-RNA pulldown analysis. hsa_circ_0031979 circRNA homo sapiens CDKN3 hsa_circ_0031979 TAGCTGCTTGTCTCCTACTATACCTGTCTGACACAATATCACCAGAGCAAGCCATAGACAGCCTGCGAGACCTAAGAGGATCCGGGGCAATACAGACCATCAAG gastric cancer 28639908 Circular RNAs play an important role in late-stage gastric cancer: Circular RNA expression profiles and bioinformatics analyses. Fang Y, Ma M, Wang J, Liu X, Wang Y. Tumour Biol. 2017 downregulated in GC microarray, qRT-PCR III stage gastric cancer and paired paracarcinoma tissue hsa_circ_0032391 circRNA homo sapiens PCNX hsa_circ_0032391 TGATCCTGGTGGAGGGATTGAAATGTCTGAGTTCATCCGAGAGGCCACACCCCCAGTTGGTTGCAGTTCCAGAAATTCTTATGCCGGTCTAGATCCAAGCAACCAGATTGGATCTGGTTCCTCGCGTCTTGGAACAGCAGCAACTATTAAAGGAGATACAGACACTGCTAAGACTTCTGATGATATCAGTTTAAGTCTGGGCCAAAGTTCTAGTCTTTGTAAGGAAGGAAGTGAAGAACAAGATTTGGCAGCTGATCGGAAGCTCTTTCGTCTTGTCTCCAATGACTCCTTCATCTCTATTCAGCCTTCCTTATCCTCTTGTGGACAGGACTTGCCAAGGGACTTCAGTGACAAAGTGAACCTGCCAAGTCATAACCACCACCACCATGTTGATCAGTCTCTGTCCAGCGCCTGTGACACAGAAGTAGCTTCTCTTGTACCTTTACACTCACACTCTTATAGAAAAGACCACCGGCCGCGAGGTGTACCACGGACTTCTAGCTCTGCTGTGGCTTTTCCAGACACTTCACTGAATGATTTTCCCCTTTATCAGCAAAGACGTGGATTAGATCCAGTTAGTGAGTTAGAATCTTCCAAGCCTCTTTCTGGATCCAAAGAATCCTTGGTGGAAAATTCTGGTTTATCTGGGGAATTTCAGCTTGCTGGTGACTTGAAAATCAATACTTCTCAGCCACCCACAAAAAGTGGGAAGAGCAAACCTTTGAAAGCAGAGAAAAGCATGGACAGCTTGAGGAGCCTGAGCACACGGAGTAGTGGGTCAACAGAAAGCTACTGCAGTGGAACGGACCGGGACACTAACAGTACTGTCAGCAGCTATAAAAGTGAGCAGACCAGCTCAACTCACATAGAGAGCATCCTGTCAGAGCATGAGGAGTCTCCTAAAGCAGGAACAAAAAGTGGGAGGAAGAAAGAGTGCTGTGCAGGCCCAGAGGAGAAGAATAGCTGTGCCAGTGACAAAAGGACTAGCAGTGAAAAGATTGCTATGGAAGCGAGTACCAACAGTGGGGTTCACGAGGCCAAGGACCCCACCCCCTCTGATGAGATGCACAACCAGAGAGGTCTCAGCACCTCTGCATCTGAAGAAGCCAATAAAAATCCCCATGCAAATGAATTTACTTCCCAAGGGGACAGACCACCTGGGAACACTGCAGAAAACAAAGAAGAGAAGAGTGATAAGTCAGCTGTTTCTGTGGATTCCAAAGTGCGTAAAGATGTTGGTGGAAAGCAAAAGGAAGGGGATGTTCGACCTAAATCTTCTAGCGTAATCCATCGGACAGCTTCTGCCCACAAGTCAGGCAGGAGACGCACAGGAAAAAAACGGGCTAGCAGTTTTGATTCAAGCCGGCATAGGGACTATGTTTGCTTTCGAGGTGTTTCTGGTACCAAGCCACACAGTGCTATATTTTGTCATGACGAAGACTCTAGTGATCAGAGTGACTTGAGTAGAGCATCAAGTGTTCAGTCTGCTCACCAGTTCAGCAGTGATAGCTCTTCTAGCACCACTTCTCATTCCTGTCAGTCTCCTGAGGGCAGATACAGTGCTCTAAAGACCAAACACACTCATAAAGAAAGGGGCACAGACTCTGAACACACACACAAAGCTCATTTGGTTCCTGAAGGAACCAGCAAAAAGCGTGCAACACGACGGACTTCTAGCACAAATAGTGCCAAGACTCGTGCCCGAGTGTTGAGCCTGGACAGTGGCACAGTAGCATGTTTGAATGACTCAAACAGGTTAATGGCACCTGAAAGTATAAAGCCCTTAACCACTTCAAAATCAGATCTTGAGGCCAAAGAGGGAGAGGTGCTAGATGAGCTATCTTTATTAGGACGGGCTTCCCAGTTAGAGACAGTCACTCGATCTAGGAATAGCTTGCCAAACCAGGTTGCATTTCCTGAAGGGGAAGAGCAAGATGCAGTCAGTGGAGCAGCACAAGCCAGCGAGGAGGCAGTGTCATTTCGCCGTGAACGCAGCACATTTAGGCGCCAGGCAGTACGGCGCCGGCACAATGCAGGGAGTAACCCTACCCCTCCTACATTGCTCATCGGATCACCCCTAAGCCTTCAAGATGGTCAGCAAGGCCAGCAGTCCACAGCCCAGGTCAAAGTCCAGTCCCGCCCCCCTTCCCAGGCTGCAGTGCTCAGTGCTAGTGCCTCCTTGCTGGTGAGAAATGGGAGTGTCCACTTAGAAGCATCACATGACAATGCATCTGCTGTAGGCGGTAGCAGTTTGCACGATGAACTTGGTAAGTTCTCTTCTACGCTGTATGAGACTGGTGGCTGTGATATGTCACTTGTGAATTTTGAACCAGCAGCAAGAAGAGCATCCAATATCTGTGACACAGATTCTCATGTATCCAGTTCTACCTCAGTTCGATTTTATCCACATGATGTGCTCTCTCTCCCACAGATTCGATTGAATAGACTATTGACCATTGATACAGATTTGTTGGAGCAACAGGACATTGATCTAAGCCCTGACTTGGCAGCTACTTACGGCCCAACAGAAGAAGCTGCCCAAAAGGTTAAACACTATTATCGCTTTTGGATCCTACCCCAGCTGTGGATTGGCATTAACTTTGACAGACTCACACTTTTGGCCCTGTTTGATAG hepatocellular carcinoma 29144509 Circular RNA expression is suppressed by androgen receptor (AR)-regulated adenosine deaminase that acts on RNA (ADAR1) in human hepatocellular carcinoma. Shi L, Yan P, Liang Y, Sun Y, Shen J, Zhou S, Lin H, Liang X, Cai X. Cell Death Dis. 2017 upregulated more than fivefold as revealed by circRNA microarray after AR knocking down in MHCC-107h cells microarray, qRT-PCR MHCC-97h, LM3 and LO13 cells hsa_circ_0032821 circRNA homo sapiens CEP128 hsa_circ_0032821 GAAAAACATATAAGCATTGAAGAGGAGCACTTAAGGAGGATGGAAGAGGCCAGATTGCAGCTCAAGGATCAACTTCTTTGCTTGGAGACTGAACAGGAATCCATTCTTGGTGTGATAGGAAAGGAAATTGATGCAGCTTGTAAAACATTCTCCAAGGACTCAGTGGAGAAATTAAAAGTTTTTTCATCTGGTCCTGATATACATTATGACCCACATCGCTGGTTAGCAGAAAGCAAGACTAAACTTCAGTGGCTCTGTGAGGAACTGAAAGAGAGAGAAAACAGAGAGAAAAATCTGCGACACCAGCTGATGCTCTGCAGACAACAACTCAGGAATTTGACTGAAAACAAGGAATCTGAGTTGCAGTGTCTCTTTCAACAGATAGAAAGGCAGGAGCAGCTTCTGGATGAAATACATCGTGAGAAGAGAG gastric cancer 28737829 Expression profile of circular RNAs in human gastric cancer tissues. Huang YS, Jie N, Zou KJ, Weng Y. Mol Med Rep. 2017 upregulated microarray, qRT-PCR GC tissues and adjacent normal tissues hsa_circ_0035381 circRNA homo sapiens PIGB hsa_circ_0035381 TTTTTTTGCCAGTTGTGCTCCTGGTTCACATGGTATTGCTGTACCAGAACCCTTACAAACACCATGGAAACTGTTCTCACTATAATTGCTCTTTTCTACTATCCTTTGGAAGGTTCAAAGTCTATGAACAGTGTCAAATACTCATCCCTGGTGGCACTTGCCTTCATAATTCGTCCCACAGCTGTCATTCTGTGGACACCTTTGCTCTTCAGACATTTCTGTCAAGAACCAAGAAAGCTTGATCTTATTCTACATCATTTTTTACCTGTAGGCTTTGTTACTTTGAGTTTGTCTCTGATGATTGATCGTATTTTTTTTGGCCAATGGACTCTGGTTCAATTTAATTTTTTGAAATTTAACGTGCTGCAGAACTGGGGAACATTTTATGGTTCTCATCCATGGCACTGGTACTTCAGTCAAGGATTTCCAGTTATCTTGGGTACTCACTTACCCTTCTTTATTCATGGCTGCTATCTAGCACCAAAGAGATACCGGATACTTTTGGTGACTGTGCTGTGGACACTGCTTGTTTATAGCATGTTGAGCCACAAAGAATTCAGGTTTATTTATCCAGTTTTACCATTCTGTATGGTGTTCTGTG Acute myeloid leukemia 28282919 Characterization of hsa_circ_0004277 as a New Biomarker for Acute Myeloid Leukemia via Circular RNA Profile and Bioinformatics Analysis. Li W, Zhong C, Jiao J, Li P, Cui B, Ji C, Ma D. Int J Mol Sci. 2017 upregulated microarray, qRT-PCR BM samples from 113 AML patients and 12 healthy controls hsa_circ_0036722 circRNA homo sapiens RHCG hsa_circ_0036722 GCTTCCAGGACGTGCACGTGATGGTCTTCGTGGGCTTCGGCTTCCTCATGACTTTCCTGCAGCGCTACGGCTTCAGCGCCGTGGGCTTCAACTTCCTGTTGGCAGCCTTCGGCATCCAGTGGGCGCTGCTCATGCAGGGCTGGTTCCACTTCTTACAAGACCGCTACATCGTCGTGGGCGTGGAGAACCTCATCAACGCTGACTTCTGCGTGGCCTCTGTCTGCGTGGCCTTTGGGGCAGTTCTGGGTAAAGTCAGCCCCATTCAGCTGCTCATCATGACTTTCTTCCAAGTGACCCTCTTCGCTGTGAATGAGTTCATTCTCCTTAACCTGCTAAAGGTGAAGGATGCAGGAGGCTCCATGACCATCCACACATTTGGCGCCTACTTTGGGCTCACAGTGACCCGGATCCTCTACCGACGCAACCTAGAGCAGAGCAAGGAGAGACAGAATTCTGTGTACCAGTCGGACCTCTTTGCCATGATTGGCACCCTCTTCCTGTGGATGTACTGGCCCAGCTTCAACTCAGCCATATCCTACCATGGGGACAGCCAGCACCGAGCCGCCATCAACACCTACTGCTCCTTGGCAGCCTGCGTGCTTACCTCGGTGGCAATATCCAGTGCCCTGCACAAGAAGGGCAAGCTGGACATGGTGCACATCCAGAATGCCACGCTCGCAGGAGGGGTGGCCGTGGGTACCGCTGCTGAGATGATGCTCATGCCTTACGGTGCCCTCATCATCGGCTTCGTCTGCGGCATCATCTCCACCCTGGGTTTTGTATACCTGACCCCATTCCTGGAGTCCCGGCTGCACATCCAGGACACATGTGGCATTAACAATCTGCATGGCATTCCTGGCATCATAGGCGGCATCGTGGGTGCTGTGACAGCGGCCTCCGCCAGCCTTGAAGTCTATGGAAAAGAAGGGCTTGTCCATTCCTTTGACTTTCAAGGTTTCAACGGGGACTGGACCGCAAGAACACAGGGAAAGTTCCAGATTTATGGTCTCTTGGTGACCCTGGCCATGGCCCTGATGGGTGGCATCATTGTGGGGCTCATTTTGAGATTACCATTCTGGGGACAACCTTCAGATGAGAACTGCTTTGAGGATGCGGTCTACTGGGAG hypopharyngeal squamous cell carcinoma 28514762 Novel circular RNA expression profiles reflect progression of patients with hypopharyngeal squamous cell carcinoma. Cao S, Wei D, Li X, Zhou J, Li W, Qian Y, Wang Z, Li G, Pan X, Lei D. Oncotarget. 2017 down microarray, qRT-PCR Tumor tissues and paired adjacent normal tissues miR-1254, miR-145-5p, miR-185-3p, miR-671-5p circRNA-miRNA Non-small cell lung cancer, Hepatocellular carcinoma, Bladder cancer, Prostate cancer, Nasopharyngeal carcinoma, Breast cancer, Glioblastoma validted in other papers (PMID:21258252, 27120784, 27072587, 25951106, 25297925, 26588055, 26683098) hsa_circ_0037111 circRNA homo sapiens None hsa_circ_0037111 CTCCTGGTTCTTGTGGAAGGTAGACGCCAGCAACTTCAGCTTGGCCTTAACCCTGACAGGGACATCTTCCCTCATCTCCGGCGGGAGGGGCGCGGAAGGGGAGCCGCTGTCATGGCTGCGACCACCCAGCGGGACCGCCCGGCCGAGCGCTCGCGGCTTCGCCTCTCCCCGCCGCCTCAACCTTCGTGGGAGCGCGGATGGAAAATGGGAAGGGGCACCGAGGCCTCGGCGGGGAGCTGCGCGGCGGCCTCGGGGGCTGCTCCCTTTGCGACCGACGCCACCGATAGGAGGGGCGGCTCCTGTCAAGCCTCAGCTTAAAAGGGCAACAGCGGCCGGGCGCGGGGGCTCCCGCCTGTCATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTCAGGAGATCGAGACCATCCCGGCTAACACGGGGAAACCCCGTCTCCACTAAAAATACAAAAAATTAGCCGGGCGCGGTGGCTCACGCCTGTAATCCTAGCACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGGGAAACCCCGTCTCTACTAAAAATACAAAAAATGAGCCGGGCGCGGTGGCGGGCGCCTGTGGTCCCAGCTACTCGGGAGGCTGGGGCAGGAGAATGGCGCGAACCCGGGAGGCGGAGCTTGCAGTGAGCCGAGATCGCGCCACCGCACTCCAGCCTGGGCGACAGAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAGAAAAAGAAAAAGGACAACAGCACCACCGTCCCCGCTACCGCCTGGGAAAGGGCTGCCCCAACCCTGCCACCTTCCCTGTCACCCCTCAACCCGGCGCGCACCCGTTTTGGCGGTTGCACGAGTCCAGAGCGTGCGCGCGCTCCCGGCTGCCCCCTCCTCCCCTTGACCCAGCACCTTTCTGCCCGACCCATCTAGTCCCTACATTCCTCACACTCGCCTACTGGAGGCTCAGGGCGGCACAACCACCAACTGTAGTGTGTGTGTTTCTCCCGAGTGTGTGTGTGTGTGTCTCCCAAGGGAACAGAGCACTGCTGAGTTCAGGTTGATTATTAGGTCGTGGACTGTCAGCAAAATGCAGTCACAAGAAGGCTGTGGGCTGTTTTGTGTTTTGCGGTGACATCATGTTGCTCATGTTTTATGTTTTTCAGAGTTCATTAGTTTCTATTTGTTCTCAGTTAATATCCACCTCAATAGATTGCATAAGTAGAATACCCCCAAACTGAAAGTCACCTACATAAAGTGTAGTGAAAAATATGTCACCCACTTAAACTATAGCTTAAACTATAGTTGAAGTTGTGTACACACTAGTTTTGTGTAGCCAACACTAGGTAATGGGTAAAGGCACAGGATCCTGGGGCTCTACTGCCTGGTTCAATTTCCAACTTTGCCATTTGCTGACTGTGAAATACTAGACAACTTTAAGCCTCAGTTTCTTTCTTTTTTTTAAACTTAATCCCAAATGTGATAGTAAGTCTCAGTTTCTTGATCTGAAAAACAGAAATTATTCAATGAGAGTCTGTGAAAACATTAAAGTTTTTAAAGCCACTGCCTGGCTCAGGAAAGTCCTCAGCTTTAGCCGTTATTAGCTATGATAATTATTGTGTTGGCTACACGTGCATTAATGAGGTAGGAAAATGCTCAAGGATAACAACCAAGTATCCAGATTATCTCATGAGACCGAGAGAGATGCATATGTGTGCATGCTCATGTTTCAGCTCAGAGCGCTTTGTCTAGAAGGCTCTTGAACTCAGAGGCCCAGGCACTATCAACTTGACTTTGCAGTGGAGGCATCACTTTTGTTGATCAATGAAATTGACATAATGCTCATTTTTTTTTTAGCACCGACCATGTGCCGAGAGCTAACTGTGTCAAGAAGAGCATGCTTCAGTTGGCTGGAGTGAGCAATTCAACTTGTGGAGGAGTGAGAAATGTTAGTGTTGAGACAAGAAACGTAAAACCCCAGGGTAAGGTAGGAATCAGTGAAAGGCAGAGGAACTGCCGTCCAGTAATGAGTTAGGCTTTGCTGGCTTCTGGCCCTACAGATGACTCTTTGGAGAGGAAAAAATTAAGCTAGGCCCGAGGGCACAGATCCTAAGGGAATGCTGGCAGCCTAGGCTGTCTATGGAAGAGAAGCAGAGGGTGGCACCTGGTTGAAAGAGGGGGTTGGGGGACAGAGCTTGAGGCTGTGTTTACAGATGGAGTCCTCTGATTCCTGTGACTGGGGAAGGAGATCGTGCTGGATCAGGGCACCTCAAATCAGAACTCTTCCCACCCACACCCCTTCTTTTCAGGGCGTCTTTCATTGCAAACAGTAGATAAACTAGTTGGAAAACTCAGCAGATTCTCACGGTGGTGCCTAGCAGGCCAGGCCTAGCTGCCGTTTAAGCTGTGACTGAGGGTGATGCCACTGGCCTGTAAACACACATTGGACAATCTTTACGTCCGTGGACACGCCATGCCCCACAGAGACAGCTGTGCATGGTTCTTTAGGTTTGGGGTGCTGTGCTGGCAGTTGCCTGATAAATGTGTAGGATTAAAATGGGATGCCCTGGAGCTTAGCTAACCTTTATCCCCCCTCCCCCCTCTAAAATGAAGGGGCTGCTAGTTTTGTTTGCTTTATGAAAGATGGATCTGTTATTGTTTTTAGAACCTTTGGAGAAAGATTTGTTGGGAGGAAGCGATCCTGAACCCCCAGAGATTTTCTCATTTACTGGTGCACCAGCTTTCGAGTCCTAGGTCTTCATCCTGGCTCAGCCACCCTCCAGCTGTGTGACCTTTGAGAAGTTGCTTGACTACACTGAGTCTCATTGTCACCTATGAGTGGAGGTTGCTACATTGCTACTGTGTGGAGCACCTACCCCCAGCCACTCTTACAGGGTGATGGTGACGATTAAATGCAATAATAAGGCTGAAGGAGGAGGATCGCTTGAAGCCAGGAGTTTGAGACTAGCCTGGGCAACAAAGCCAGACCACATTTCTATGAAAATGTTTTTTTAAAAAATTAGCTGGACTTGGTGGCTTGGGCCTACAGTCCAGCTACTCGAGAGGCTGAGGTGAGACCACTTGAGCCCAGGAGCTTGAGGCTGCAGTGAGCTGTGATTGCACCACTGCACTCCCGCCCAGGAAACAGAGAGAGACCCTATCTCAAATAAATGAATAAGTAAATAAATAAAATAATAAAATAATGCATGCAATTAGTACACTAGTACATGATCAGGCACATGATAACTGCTCGATAAATGGTAGCCTCAGTAAACTTTATAATGTTTTAAAGGAGAATGTCCTTTGGACTCAGCCTTTCAAATGACAGAGCATTTGAAAAGACTGATTTGTATGATGGCTATTTCCTACAGATACAAGACTGTACCTCCAGGGACTCAAGGCATTGGCTCAGTGGGGCACCTTGTTCTGTTTACTCTTGTTTTGGTCAGCACCGATTGCCCTAGGGCTAAGCAGGGCTGCCACCACAGACTCAGTTGCCAAGAGTATCCCCCTCCCCAAGCTAGCCATGGGAAAGCCACTCGCATTGTAAGACTACAGGAAATCAAAGGGAATAAAAAGCACAATTTAGTCACCTACTCTCCAGTTGATGGGCAATAGGTTTTTGCTATTTTGAACAGAGCTGTTAGGAACATTCCTTGTCCACATCCCCTGTTTTATATAGGCAAGAATTTCTCTTCCACGTAGAGTAGAATTACTGGGCTAGGAGGAGTGTGAATATTGAACCTTATGAGATGGAGCCAAACTGTTTTCCAAAGTGGTCATACCAGTGTATACTCCCAGCAGCAGTTCTTAAGAGATCTCAGGATGTCTATCTTCTGGTGATTTCACAAGCAGTCAAAAAGAATGAACGCCAGCAATAAACAACAATAAGAACTTTAGCAATATAATATTGTGAGAAAAACAAATTCCAGAAGGATGCATACAGAATACTTTATATAACATGGAAAAGAAAATGTATAGACCCAGCATGGTGGCTCATGCCTGTAATCCTGGCACTTTGGGAGGCCAAGGCAGGAGGATTGCTTGAGGCCAGGAGTTCAAGACCAGCCTGGGCAACATAGCAAAACCCTTTCTCTACAAAAACTAGAAAAATTAGCCAGGTGTGGTGGTGCAGGCATGTAGTCCTAGCTACTCATGAGGCTGAGACGGGAGGATCTCTTGAGTTTAGGTGTTCAAGGTTACAGTGAGCCCATGATTGCACCACTGCACTCCAGCCTGGGCAACAGAATGAGACCCTGTTTGCAAAAGAGAAAAACAAGTAAATAAGTAAAATTTAAAAACAAAATGTGGGCTGGGCACGGATTCTCATGCCTGTAACCCCAGCACTTTGCGGGGCCGAAGTGGGTACCTTATGAGGTCAGGAGTTCAATACCAGCCTGATCAACATGGTGAAACCATGTCTCTACTAAAAATAGAAAAATTACCCAGGGTGGTGGTACGCGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCCAGGATTGTGCCATTGCACTCCAGCCTGGGTGACAAAGCAAGATTCCATCTCAAAAAAAAAAATTATTTTTTTAAAAAGATAACATTGACAAACAAAAGGAAACATGACAACTGATACCACAAAAACTCAAAGGATCACTAGTGGCTATTATCAGCAACTATATGCAAACAAATGGGAAAACCTACTAAAAATGGATAAATTTCCAGACACATCCAGACTACCAAGACTGAACCGGGATGAAATCCAAAGCCAGAACAGACCAACAACAAATAATGGGATCGAAGCAGTAATGAAAAGTCTCCCAGCAAAGAAAAGCCTGGGACCTGATGATTCACTGCTGAATTCTAGCAAACATTTAAAGAAGAACTAATACCAACCTTACCCAAACGATTCCAAAAATAGAGAAGGAGGGAATACTTCCAAACTCATTCTACAAGGCTAGTATTACCCTGATACCAAAACTAAAGATACATCCAAAAAAGAAAACTACAGGCCAGGATCACTGATGAATATTGATGCAAAAATCCTCAACAAAATATTAGCTAATTGAATTCAACAACACATTAAAGTTGGGGTGCAGTGTCCCAGGTTCACTCAACCCTTCCCGTTTTCTTGTCTGTGTGTGTCTACTTTGCTCTGTTCCCTGGTGGCAGCGGCGGTGGCAATGTTGGTGCATGGGCCTCCTAGGACAAGGGGAAAGTGAGTATGCCCTTTTCTTGCTTCCTGCCAGGCATCTGCAGCCTGGCGCAAGCTCTGGCCAGGTCTTCAAGCAAGGTACCTGGAGATGTTCTTTTCCAATTTCTGGATTGGTAACTTGAGGCAAATTCTGGGCACTAGAGTCAGGACTAAGATGAGACTTGAATCAGGGGAGTCTGGGGTCCTGAGAGGCAGAGGCCTGAAACCATCTAGAGCATGTGGGGACCTGGGTGTGTGTTCAGGCCAGTTGCCTTTCTCTGTGCTTCAATGTTCCAGGTACCCTTGGAGGGACTGAGATCCTAGGGATTGCTGGAGCCTGGCTGCATGGCCTGGCCACCCTGATGCGCTTGCATTCTCCGTGACAGGACAGCAAGGCTGAGGAGAATGGCTCCCACAGCTTCATGCACTCCATGGACCCACAGCTGGAGCGGCAAATGGAAACCACCCAGAACCTGGTGGACTCCTACATGGCCATTGTCAACAAGACCGTGTGGAACCTCATGGTTGGTGCGAAGCCCAAGACCATCATGCACATCATGATCTACAATGTGCATGCACCGCCTCATGGGGGTAGGCGGCTCCTGTGGCACTGGGGATGCAGGTGGCCATGTTGGCCTGGGGGAGATGCTGACCAGCCCTATGGGACCAGGTCCAGGGAGGGAGGCATGGTCCAGACCAGAGCTGTCTCATAGAAATATAACATGGGACTGAGGACAGTGGTCCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGAGGATAGCTTGAGCCCAGGAGTTCGAGACCAGCCTGGGCAACATAGTGAGACCTGGCCTCTACACAAAAATTTTAAAAATAGCTGGGCTTGGTGGTGGCACGTGCCTATAGTCCTAGCTACTCGACAGGCTGACATTAGAGGATCACTTTGAGCCCAAGAGGTTGAGGATGCAGTGAGCGGTGATCTCGCCCTCTATACTCCAGCCTAGCGACAGAGTGAGATCCTATCTCCAAAAAAAATTTGAAAAACCTGAGTAGACAGGTGTCCTGGTAGCATGATAGGTCCAGGGTCCCCTCCCAGATCTGTGACTTGCACAGGCGACCTTTCCTCTGGACCTCAGCGTCCCTATCTGAGTGAGAAAAGGGCAATGGGGAGGCAGATCTTTGAGTTTAAGCTGTGTAGAAGCCACATCTGAAAAGCCATACTCAGGGCTTCAACTCCAGCACACAGTCCCAGCAGGCGCCAGCGGGAGGCCAGGGCAGCACGGGCATCAGGACCCAAACTCCTTCCTTCTTTGCCCACTCTCAGACCAAGGAGTTCATCTTCTCAGAGCTGCTGTCCAACCTGTACTCGCGTGGGAACAAGGAGACACTCCTGGAGGAGTCGGCAGAGCAGGCACAGCGGCGCGACGAGATGCTGCTTCTCAGAGCTGCTGTCCAACCTGCACTCGCGTGGGAACGAGAAGACACTCGTGGAG endometrial cancer 29334253 Circular RNA expression in extracellular vesicles isolated from serum of patients with endometrial cancer. Xu H, Gong Z, Shen Y, Fang Y, Zhong S. Epigenomics. 2018 up RNA-seq, northern blots extracellular vesicles isolated from serum of patients with endometrial cancer hsa_circ_0037911 circRNA homo sapiens GSPT1 hsa_circ_0037911 CACCTGTGGAATCCTCTCAAGAGGAACAGTCATTGTGTGAAGGTTCAAATTCAGCTGTTAGCATGGAACTTTCAGAACCTATTGTAGAAAATGGAGAGACAGAAATGTCTCCAGAAGAATCATGGGAGCACAAAGAAGAAATAAGTGAAGCAGAGCCAGGGGGTGGTTCCTTGGGAGATGGAAGGCCGCCAGAGGAAAGTGCCCATGAAATGATGGAGGAGGAAGAGGAAATCCCAAAACCTAAGTCTGTGGTTGCACCGCCAGGTGCTCCTAAGAAAGAGCATGTAAATGTAGTATTCATTGGGCACGTAGATGCTGGCAAGTCAACCATTGGAGGACAAATAAT essential hypertension 29526758 A potential risk factor of essential hypertension in case-control study: Circular RNA hsa_circ_0037911. Bao X, Zheng S, Mao S, Gu T, Liu S, Sun J, Zhang L. Biochem Biophys Res Commun. 2018 The hsa_circ_0037911 expression level in EH cases were significantly higher than healthy controls (p = 0.005). There was still important significance when adjusted by logistic regression (adjusted p = 0.026). We also found that hsa_circ_0037911 was an effective marker of EH (area under curve = 0.627; p = 0.002). The levels of hsa_circ_0037911 were significantly differences in gender, BMI, smoking and drinking among EH cases. There was a positive correlation between Serum creatinine (Scr) and hsa_circ_0037911. qRT-PCR blood samples of essential hypertension cases and controls hsa_circ_0040039 circRNA homo sapiens SNTB2 hsa_circ_0040039 TCAAGTTCATCCGAGAAGTAACACCATATATCAAGAAGCCATCATTAGTATCAGATCTGCCGTGGGAAGGTGCAGCCCCCCAGTCACCAAGCTTTAGTGGCAGTGAGGACTCTGGTTCGCCAAAACACCAGAACAGCACCAAGGACAGGAAGATCATCCCTCTCAAAATGTGCTTTGCTGCTAGAAACCTAAGCATGCCGGATCTGGAAAACAGATTGATAGAGCTACATTCTCCTGATAGCAGGAACACGTTGATCCTACGCTGCAAAGATACAGCCACAGCACACTCCTGGTTCGTAGCTATCCACACCAACATAATGGCTCTCCTCCCACAGGTGTTGGCTGAACTCAACGCCATGCTTGGGGCAACCAGTACAGCAGGAGGCAGTAAAGAGGTGAAGCATATTGCCTGGCTGGCAGAACAGGCAAAACTAGATGGTGGAAGACAGCAATGGAGACCTGTCCTCATGGCTGTGACTGAGAAGGATTTGCTGCTCTATGACTGTATGCCGTGGACAAGAGATGCCTGGGCGTCACCATGCCACAGCTACCCACTTGTTGCCACCAGGTTGGTTCATTCTGGCTCCGGATGTCGATCCCCCTCCCTTGGATCTGACCTTACATTTGCTACCAGGACAGGCTCTCGACAGGGCATTGAGATGCATCTCTTCAGGGTGGAGACACATCGGGATCTGTCATCCTGGACCAGGATACTTGTTCAGGGTTGCCATGCTGCTGCTGAGCTGATCAAGGAAGTCTCTCTAG gastric cancer 28737829 Expression profile of circular RNAs in human gastric cancer tissues. Huang YS, Jie N, Zou KJ, Weng Y. Mol Med Rep. 2017 downregulated microarray, qRT-PCR GC tissues and adjacent normal tissues hsa_circ_0040081 circRNA homo sapiens NQO1 hsa_circ_0040081 AGTAAGAAGGCAGTGCTTTCCATCACCACTGGTGGCAGTGGCTCCATGTACTCTCTGCAAGGGATCCACGGGGACATGAATGTCATTCTCTGGCCAATTCAG hepatoblastoma 29414822 Expression Profiling Identifies Circular RNA Signature in Hepatoblastoma. Liu BH, Zhang BB, Liu XQ, Zheng S, Dong KR, Dong R. Cell Physiol Biochem. 2018 down microarray, qRT-PCR hepatoblastoma and adjacent normal liver samples KIRKOS-71 circRNA homo sapiens WWOX hsa_circ_0040571 TCACACCGAGGAGAAGACTCAGTGGGAACATCCAAAAACTGGAAAAAGAAAACGAGTGGCAGGAGATTTGCCATACGGATGGGAACAAGAAACTGATGAGAACGGACAAGTGTTTTTTGTTGACCATATAAATAAAAGAACCACCTACTTGGACCCAAGACTGGCGTTTACTGTGGATGATAATCCGACCAAGCCAACCACCCGGCAAAGATACGACGGCAGCACCACTGCCATGGAAATTCTCCAGGGCCGGGATTTCACTGGCAAAGTGGTTGTGGTCACTGGAGCTAATTCAGGAATAGGGTTCGAAACCGCCAAGTCTTTTGCCCTCCATGGTGCACATGTGATCTTGGCCTGCAGGAACATGGCAAGGGCGAGTGAAGCAGTGTCACGCATTTTAGAAGAATGGCATAAAGCCAAGGTAGAAGCAATGACCCTGGACCTCGCTCTGCTCCGTAGCGTGCAGCATTTTGCTGAAGCATTCAAGGCCAAGAATGTGCCTCTTCATGTGCTTGTGTGCAACGCAGCAACTTTTGCTCTACCCTGGAGTCTCACCAAAGATGGCCTGGAGACCACCTTTCAAGTGAATCATCTGGGGCACTTCTACCTTGTCCAGCTCCTCCAGGATGTTTTGTGCCGCTCAGCTCCTGCCCGTGTCATTGTGGTCTCCTCAGAGTCCCATCGATTTACAGATATTAACGACTCCTTGGGAAAACTGGACTTCAGTCGCCTCTCTCCAACAAAAAACGACTATTGGGCGATGCTGGCTTATAACAGGTCCAAGCTCTGCAACATCCTCTTCTCCAACGAGCTGCACCGTCGCCTCTCCCCACGCGGGGTCACGTCGAACGCAGTGCATCCTGGAAATATGATGTACTCCAACATTCATCGCAGCTGGTGGGTGTACACACTGCTGTTTACCTTGGCGAGGCCTTTCACCAAGTCCATG 29108237 The circRNA interactome-innovative hallmarks of the intra- and extracellular radiation response. OLeary VB, Smida J, Matjanovski M, Brockhaus C, Winkler K, Moertl S, Ovsepian SV, Atkinson MJ. Oncotarget. 2017 Down regulated transcript levels were detected for KIRKOS-71 particularly 24 hr post low (0.63 ¡À 0.05 fold, p = 0.002)and medium (0.64 ¡À 0.08 fold, p = 0.05) irradiation in SHEP. In contrast, KIRKOS-71 transcript levels were highly significantly increased in U2OS 24 hr post 0.25 Gy (1.52 ¡À 0.09 fold increase, p = 0.0001) in comparison to sham irradiated control cells. Following medium dose exposure, this circRNA was similarly elevated post 4 hr and 24 hr (2.0 ¡À 0.26 fold increase, p = 0.017; 1.3 ¡À 0.1 fold increase, p = 0.006 respectively) compared to controls. Exosomes were extracted from SHEP and U2OS 24 hr following 2.5 Gy, 0.25 Gy or sham irradiation. KIRKOS-71 was significantly down regulated at this time point post 2.5 Gy in exosomes isolated from SHEP in comparison to sham irradiated controls (p = 0.002 and p = 0.000057, respectively). KIRKOS-71 was also significantly down regulated 24 hr post 0.25 Gy in exosomes from this cell line in comparison to sham. microarray, qRT-PCR Human umbilical vein endothelial cells, neuroblastoma cell line SHEP, osteosarcoma cell line U2OS, QKI-5 circRNA-protein U2OS RNA pull-down, qPCR QPCR amplification confirmed the presence of the KIRKOS-71 associating with QKI-5 in U2OS. KIRKOS-73 circRNA homo sapiens WWOX hsa_circ_0040573 GCCTCTTCATGTGCTTGTGTGCAACGCAGCAACTTTTGCTCTACCCTGGAGTCTCACCAAAGATGGCCTGGAGACCACCTTTCAAGTGAATCATCTGGGGCACTTCTACCTTGTCCAGCTCCTCCAGGATGTTTTGTGCCGCTCAGCTCCTGCCCGTGTCATTGTGGTCTCCTCAGAGTCCCATCGATTTACAGATATTAACGACTCCTTGGGAAAACTGGACTTCAGTCGCCTCTCTCCAACAAAAAACGACTATTGGGCGATGCTGGCTTATAACAGGTCCAAGCTCTGCAACATCCTCTTCTCCAACGAGCTGCACCGTCGCCTCTCCCCACGCGGGGTCACGTCGAACGCAGTGCATCCTGGAAATATGATGTACTCCAACATTCATCGCAGCTGGTGGGTGTACACACTGCTGTTTACCTTGGCGAGGCCTTTCACCAAGTCCATG 29108237 The circRNA interactome-innovative hallmarks of the intra- and extracellular radiation response. OLeary VB, Smida J, Matjanovski M, Brockhaus C, Winkler K, Moertl S, Ovsepian SV, Atkinson MJ. Oncotarget. 2017 KIRKOS-73 was found to be significantly down-regulated in HUVEC 4 and 24 hr post low dose irradiation. This circRNA was down-regulated in the neuroblastoma cell line SHEP 24 hr post low (0.58 ¡À0.12 fold, p = 0.04) and medium (0.67 ¡À 0.2 fold, p =0.01) dose exposure. In contrast, KIRKOS-73 showed a significantly elevated expression profile in the osteosarcoma cell line U2OS by 24 hr post 0.25 Gy in comparison to sham-irradiated control conditions (2.95 ¡À 0.29 fold increase, p = 0.01). This circRNA was also upregulated in this cell line post 4 hr (1.09 ¡À 0.11 fold increase, p = 0.01) and 24 hr (1.3 ¡À 0.03 fold increase, p = 0.0008) after 2.5 Gy exposure compared to controls. Exosomes were extracted from SHEP and U2OS 24 hr following 2.5 Gy, 0.25 Gy or sham irradiation. KIRKOS-73 was found to be significantly upregulated in exosomes post 2.5 Gy in U2OS in comparison to their individual sham irradiated controls (p = 0.0008 and p = 0.011, respectively). In contrast, it was significantly down regulated at this time point post 2.5 Gy in exosomes isolated from SHEP in comparison to sham irradiated controls (p = 0.002 and p = 0.000057, respectively). microarray, qRT-PCR Human umbilical vein endothelial cells, neuroblastoma cell line SHEP, osteosarcoma cell line U2OS, QKI-5 circRNA-protein U2OS RNA pull-down, qPCR QPCR amplification confirmed the presence of the KIRKOS-73 associating with QKI-5 in U2OS. hsa_circ_0041150 circRNA homo sapiens RPH3AL hsa_circ_0041150 ATGTGACTCCCCACCCCCAGCCGGGTGCTCCGAGCCATGGCCGACACCATCTTCGGCAGCGGGAATGATCAGTGGGTTTGCCCCAATGACCGGCAGCTTGCCCTTCGAGCCAAGCTGCAGACGGGCTGGTCCGTGCACACCTACCAGACGGAGAAGCAGAGGAGGAAGCAGCACCTCAGCCCGGCGGAGGTGGAGGCCATCCTGCAGGTCATCCAGAGGGCAGAGCGGCTCGACGTCCTGGAGCAGCAGAGAATCGGGCGGCTGGTGGAGCGGCTGGAGACCATGAGGCGGAATGTGATGGGGAACGGCCTGTCCCAGTGTCTGCTCTGCGGGGAGGTGCTGGGCTTCCTGGGCAGCTCGTCGGTGTTCTGCAAAGACTGCAGGAAGAAAGTCTGCACCAAATGTGGGATCGAGGCCTCCCCTGGCCAGAAGCGGCCCCTGTGGCTGTGTAAGATCTGCAGTGAGCAAAGAGAG pancreatic ductal adenocarcinoma 27997903 Circular RNA Expression Profile of Pancreatic Ductal Adenocarcinoma Revealed by Microarray. Li H, Hao X, Wang H, Liu Z, He Y, Pu M, Zhang H, Yu H, Duan J, Qu S. Cell Physiol Biochem. 2016 down microarray, qRT-PCR PDAC samples and corresponding normal tissues hsa_circ_0041731 circRNA homo sapiens FAM64A hsa_circ_0041731 CGCAGAGTTTCAAATCGGCTGCGGTGGGCGAGGAGCAGCTGTGCTGCGGCTGTGCTCGGCCTTAGTGGTGTCGGGGTCTAGTGGACAGAGAAGACTCTTGGCCAGGCAGATGGCTTCTCGGTGGCAGAACATGGGGACCTCCGTGCGCCGGAGATCTCTCCAGCACCAGGAGCAGCTGGAGGACAGCAAGGAGCTGCAGCCTGTGGTCAGCCATCAGGAGACCTCTGTAGGGGCCCTGGGGTCCCTGTGCAGACAGTTCCAAAGGAGGCTGCCCCTGAGAGCCGTCAACCTCAACCTCCGCGCAGGGCCCTCCTGGAAACGCCTGGAAACCCCAGAGCCAGGTCAGCAGGGCCTCCAGGCTGCAGCTCGCTCAGCTAAGAGTGCTTTGGGTGCCGTGTCCCAGAGAATCCAGGAGTCCTGCCAAAGTGGCACCAAGTGGCTGGTGGAGACCCAGGTGAAGGCCAGGAGGCGGAAGAGAGGAGCACAGAAGGGCAGTGGATCCCCAACTCACAGCCTGAGCCAGAAGAGCACCCGGCTGTCTGGAGCCGCCCCTGCCCACTCAGCCGCAGACCCCTGGGAGAAGGAGCATCACCGCCTCTCTGTCCGGATGGGCTCACATGCCCACCCATTACGGCGATCAAGGCGGGAGGCTGCCTTCCGGAGCCCCTACTCCTCAACAGAGCCCCTCTGCTCTCCCAGCGAGTCTGACAGTGACCTAGAGCCTGTGGGGGCGGGAATTCAGCATCTCCAGAAGCTGTCCCAAGAGCTAGATGAAGCCATTATGGCGGAAGAGAGTGGTGACATCGTCTCTCTCATTCATGACTGAGGAAGTGCCTGCAG hepatoblastoma 29414822 Expression Profiling Identifies Circular RNA Signature in Hepatoblastoma. Liu BH, Zhang BB, Liu XQ, Zheng S, Dong KR, Dong R. Cell Physiol Biochem. 2018 down microarray, qRT-PCR hepatoblastoma and adjacent normal liver samples hsa_circ_0041732 circRNA homo sapiens FAM64A hsa_circ_0041732 AGAATCCAGGAGTCCTGCCAAAGTGGCACCAAGTGGCTGGTGGAGACCCAGGTGAAGGCCAGGAGGCGGAAGAGAGGAGCACAGAAGGGCAGTGGATCCCCAACTCACAGCCTGAGCCAGAAGAGCACCCGGCTGTCTGGAGCCGCCCCTGCCCACTCAGCCGCAGACCCCTGGGAGAAGGAGCATCACCGCCTCTCTGTCCGGATGGGCTCACATGCCCACCCATTACGGCGATCAAGGCGGGAGGCTGCCTTCCGGAGCCCCTACTCCTCAACAGAGCCCCTCTGCTCTCCCAG gastric cancer 28737829 Expression profile of circular RNAs in human gastric cancer tissues. Huang YS, Jie N, Zou KJ, Weng Y. Mol Med Rep. 2017 downregulated microarray, qRT-PCR GC tissues and adjacent normal tissues hsa_circ_0041796 circRNA homo sapiens C17orf81 hsa_circ_0041796 GCTGGTTTACCATGACTTCTTCAGAGACCCTCTCAACTGGTCAAAAACTGAGGAGGCCTTTCCTGGGGGGCCGCTGGGAGCCTTGAGAGCCATGTGCAAGAGGACAGATCCTGTTCCTGTCACCATTGCTCTCGATTCACTCAGCTGGCTGCTACTTCGCCTTCCCTGCACCACACTCTGCCAGGTCCTGCATGCTGTGAGCCATCAGGACTCTTGTCCTGGTGAGACCCCTCCTTCATTGTTTCCCCTCATACATCTCCCTCTGCCAAGGAGTGTGCCCCTTTTCCTTTCTACCCTAGAATAAACATCTGGGTTCTCCAGTCAGAC Diabetes Retinopathy 29288268 Identification and Characterization of Circular RNAs as a New Class of Putative Biomarkers in Diabetes Retinopathy. Zhang SJ, Chen X, Li CP, Li XM, Liu C, Liu BH, Shan K, Jiang Q, Zhao C, Yan B. Invest Ophthalmol Vis Sci. 2017 Downregulated in diabetic human retinas compared to nodiabetic retinas. microarray, qRT-PCR diabetic human retinas, nodiabetic retinas hsa_circ_0043256 circRNA homo sapiens ACACA hsa_circ_0043256 AAACATGGTGGTGGCTTTGAAGGAGCTGTCTATTCGGGGTGACTTTCGAACTACAGTTGAATACCTGATCAAATTGTTAGAGACTGAAAGCTTTCAGATGAACAGAATTGATACTGGCTGGCTGGACAGACTGATAGCAGAAAAAGTACAGGCTGAGCGACCTGACACCATGTTGGGGGTTGTGTGTGGTGCCCTCCACGTGGCAGATGTGAGCCTGCGGAATAGCGTCTCTAACTTCCTTCACTCCTTAGAAAGGGGTCAAGTCCTTCCTGCTCATACACTTCTGAATACAGTAGATGTTGAACTTATCTATGAGGGAGTCAAGTATGTACTTAAGGTGACTCGACAGTCCCCCAACTCCTATGTGGTGATCATGAATGGCTCATGTGTAGAAGTAGATGTACATCGGCTGAGTGACGGTGGACTGCTCTTGTCCTATGATGGCAGCAGTTATACTACGTATATGAAAGAGGAAGTGGATAG non-small cell lung cancer 28958934 Cinnamaldehyde induces cell apoptosis mediated by a novel circular RNA hsa_circ_0043256 in non-small cell lung cancer. Tian F, Yu CT, Ye WD, Wang Q. Biochem Biophys Res Commun. 2017 hsa_circ_0043256 was upregulated in NSCLC cells in response to cinnamaldehyde treatment microarray, qRT-PCR NCI-H460 and A549 Hsa_circ_0043256 could inhibit cell proliferation and induce apoptosis. hsa_circ_0043256 knock-down could weaken Wnt/¦Â-catenin pathway inhibition induced by CA. loss of function, gain of function NCI-H460 and A549 Male BALB/c nude mice miR-1252 circRNA-miRNA NCI-H460 and A549 luciferase reporter assay, Ago2 RIP The luciferase activity markedly decreased upon the combination of hsa_circ_0043256 and miR-1252. Flag-Ago2 RIP results confirmed that hsa_circ_0043256 could bind miR-1252 to work as miRNA sponge. ITCH CA induced apoptosis and meanwhile upregulated hsa_circ_0043256 expression in vivo. hsa_circ_0043534 circRNA homo sapiens TOP2A hsa_circ_0043534 ATGTCACTAATGATGACCATTATCAATTTGGCTCAGAATTTTGTGGGTAGCAATAATCTAAACCTCTTGCAGCCCATTGGTCAGTTTGGTACCAGGCTACATGGTGGCAAGGATTCTGCTAGTCCACGATACATCTTTACAATGCTCAGCTCTTTGGCTCGATTGTTATTTCCACCAAAAGATGATCACACGTTGAAGTTTTTATATGATGACAACCAGCGTGTTGAGCCTGAATGGTACATTCCTATTATTCCCATGGTGCTGATAAATGGTGCTGAAGGAATCGGTACTGGGTGGTCCTGCAAAATCCCCAACTTTGATGTGCGTGAAATTGTAAATAACATCAGGCGTTTGATGGATGGAGAAGAACCTTTGCCAATGCTTCCAAGTTACAAGAACTTCAAGGGTACTATTGAAGAACTGGCTCCAAATCAATATGTGATTAGTGGTGAAGTAGCTATTCTTAATTCTACAACCATTGAAATCTCAGAGCTTCCCGTCAGAACATGGACCCAGACATACAAAGAACAAGTTCTAGAACCCATGTTGAATGGCACCGAGAAGACACCTCCTCTCATAACAGACTATAGGGAATACCATACAGATACCACTGTGAAATTTGTTGTGAAGATGACTGAAGAAAAACTGGCAGAGGCAGAGAGAGTTGGACTACACAAAGTCTTCAAACTCCAAACTAGTCTCACATGCAACTCTATGGTGCTTTTTGACCACGTAGGCTGTTTAAAGAAATATGACACGGTGTTGGATATTCTAAGAGACTTTTTTGAACTCAGACTTAAATATTATGGATTAAGAAAAGAATGGCTCCTAGGAATGCTTGGTGCTGAATCTGCTAAACTGAATAATCAGGCTCGCTTTATCTTAGAGAAAATAGATGGCAAAATAATCATTGAAAATAAGCCTAAGAAAGAATTAATTAAAGTTCTGATTCAGAGGGGATATGATTCGGATCCTGTGAAGGCCTGGAAAGAAGCCCAGCAAAAGGTTCCAGATGAAGAAGAAAATGAAGAGAGTGACAACGAAAAGGAAACTGAAAAGAGTGACTCCGTAACAGATTCTGGACCAACCTTCAACTATCTTCTTGATATGCCCCTTTGGTATTTAACCAAGGAAAAGAAAGATGAACTCTGCAGGCTAAGAAATGAAAAAGAACAAGAGCTGGACACATTAAAAAGAAAGAGTCCATCAGATTTGTGGAAAGAAGACTTGGCTACATTTATTGAAGAATTGGAGGCTGTTGAAGCCAAGGAAAAACAAGATGAACAAGTCGGACTTCCTGGGAAAGGGGGGAAGGCCAAGGGGAAAAAAACACAAATGGCTGAAGTTTTGCCTTCTCCGCGTGGTCAAAGAGTCATTCCACGAATAACCATAGAAATGAAAGCAGAGGCAGAAAAGAAAAATAAAAAGAAAATTAAGAATGAAAATACTGAAGGAAGCCCTCAAGAAGATGGTGTGGAACTAGAAGGCCTAAAACAAAGATTAGAAAAGAAACAGAAAAGAGAACCAGGTACAAAGACAAAGAAACAAACTACATTGGCATTTAAGCCAATCAAAAAAGGAAAGAAGAGAAATCCCTGGTCTGATTCAGAATCAGATAGGAGCAGTGACGAAAGTAATTTTGATGTCCCTCCACGAGAAACAGAGCCACGGAGAGCAGCAACAAAAACAAAATTCACAATGGATTTGGATTCAGATGAAGATTTCTCAGATTTTGATGAAAAAACTGATGATGAAGATTTTGTCCCATCAGATGCTAGTCCACCTAAGACCAAAACTTCCCCAAAACTTAGTAACAAAGAACTGAAACCACAGAAAAGTGTCGTGTCAGACCTTGAAGCTGATGATGTTAAGGGCAGTGTACCACTGTCTTCAAGCCCTCCTGCTACACATTTCCCAGATGAAACTGAAATTACAAACCCAGTTCCTAAAAAGAATGTGACAGTGAAGAAGACAGCAGCAAAAAGTCAGTCTTCCACCTCCACTACCGGTGCCAAAAAAAGGGCTGCCCCAAAAGGAACTAAAAGGGATCCAGCTTTGAATTCTGGTGTCTCTCAAAAGCCTGATCCTGCCAAAACCAAGAATCGCCGCAAAAGGAAGCCATCCACTTCTGATGATTCTGACTCTAATTTTGAGAAAATTGTTTCGAAAGCAGTCACAAGCAAGAAATCCAAGGGGGAGAGTGATGACTTCCATATGGACTTTGACTCAGCTGTGGCTCCTCGGGCAAAATCTGTACGGGCAAAGAAACCTATAAAGTACCTGGAAGAGTCAGATGAAGATGATCTGTTTTAAAATGTGAGGCGATTATTTTAAGTAATTATCTTACCAAGCCCAAGACTGGTTTTAAAGTTACCTGAAGCTCTTAACTTCCTCCCCTCTGAATTTAGTTTGGGGAAGGTGTTTTTAGTACAAGACATCAAAGTGAAGTAAAGCCCAAGTGTTCTTTAGCTTTTTATAATACTGTCTAAATAGTGACCATCTCATGGGCATTGTTTTCTTCTCTGCTTTGTCTGTGTTTTGAGTCTGCTTTCTTTTGTCTTTAAAACCTGATTTTTAAGTTCTTCTGAACTGTAGAAATAGCTATCTGATCACTTCAGCGTAAAGCAGTGTGTTTATTAACCATCCACTAAGCTAAAACTAGAGCAGTTTGATTTAAAAGTGTCACTCTTCCTCCTTTTCTACTTTCAGTAGATATGAGATAGAGCATAATTATCTGTTTTATCTTAGTTTTATACATAATTTACCATCAGATAGAACTTTATGGTTCTAGTACAGATACTCTACTACACTCAGCCTCTTATGTGCCAAGTTTTTCTTTAAGCAATGAGAAATTGCTCATGTTCTTCATCTTCTCAAATCATCAGAGGCCGAAGAAAAACACTTTGGCTGTGTCTATAACTTGACACAGTCAATAGAATGAAGAAAATTAGAGTAGTTATGTGATTATTTCAGCTCTTGACCTGTCCCCTCTGGCTGCCTCTGAGTCTGAATCTCCCAAAGAGAGAAACCAATTTCTAAGAGGACTGGATTGCAGAAGACTCGGGGACAACATTTGATCCAAGATCTTAAATGTTATATTGATAACCATGCTCAGCAATGAGCTATTAGATTCATTTTGGGAAATCTCCATAATTTCAATTTGTAAACTTTGTTAAGACCTGTCTACATTGTTATATGTGTGTGACTTGAGTAATGTTATCAACGTTTTTGTAAATATTTACTATGTTTTTCTATTAGCTAAATTCCAACAATTTTGTACTTTAATAAAATGTTCTAAACATTGCAACCCA hepatoblastoma 29414822 Expression Profiling Identifies Circular RNA Signature in Hepatoblastoma. Liu BH, Zhang BB, Liu XQ, Zheng S, Dong KR, Dong R. Cell Physiol Biochem. 2018 down microarray, qRT-PCR hepatoblastoma and adjacent normal liver samples hsa_circ_0045510 circRNA homo sapiens ABCA9 hsa_circ_0045510 GCAGGTGATTCGGGCCACCTTTAGAAACACGGAGAGGGGCGCCCTCCTGACCACCCACTACATGGCAGAGGCTGAGGCGGTGTGTGACCGAGTGGCCATCATGGTGTCAGGAAGGCTGAGATGTATTGGTTCCATCCAACACCTGAAAAGCAAATTTGGCAAAGACTACCTGCTGGAGATGAAGCTGAAGAACCTGGCACAAATGGAGCCCCTCCATGCAGAGATCCTGAGGCTTTTCCCCCAGGCTGCTCAGCAGGAAAGGTTCTCCTCCCTGATGGTCTATAAGTTGCCTGTTGAGGATGTGCGACCTTTATCACAGGCTTTCTTCAAATTAGAGATAGTTAAACAGAGTTTCGACCTGGAGGAGTACAGCCTCTCACAGTCTACCCTGGAGCAG hepatoblastoma 29414822 Expression Profiling Identifies Circular RNA Signature in Hepatoblastoma. Liu BH, Zhang BB, Liu XQ, Zheng S, Dong KR, Dong R. Cell Physiol Biochem. 2018 up microarray, qRT-PCR hepatoblastoma and adjacent normal liver samples hsa_circ_0045714 circRNA homo sapiens UNK hsa_circ_0045714 GTGCCCATTCCTGCACAGAACCACAGGGGACACTGAGCGCAGGTACCACCTTCGTTACTACAAAACTGGAATCTGCATCCACGAGACAGACTCGAAAGGCAACTGCACCAAAAACGGCCTGCACTGCGCTTTTGCCCACGGGCCCCATGACCTCCGCTCCCCTGTCTACGACATCAGGGAGCTTCAGGCCATGGAGGCCTTGCAGAATGGCCAGACCACGGTAGAGGGGAGCATAGAGGGCCAGTCGGCTGGGGCTGCGAGCCATGCCATGATAGAAAAGATCCTCAGCGAGGAGCCTCGGTGGCAAGAGACTGCTTATGTGCTGGGGAACTATAAGACGGAGCCTTGCAAGAAGCCCCCGCGGCTGTGCCGCCAAGGCTATGCCTGTCCCTACTACCACAACAGCAAGGACCGGCGGCGGAGCCCCCGGAAGCACAAATACAGGTCGTCTCCATGTCCAAACGTCAAGCACGGGGATGAGTGGGGAGACCCTGGCAAGTGTGAGAACGGAGACGCCTGCCAGTACTGCCACACCCGCACCGAGCAGCAGTTCCACCCCGAG osteoarthritis 28795385 Hsa_circ_0045714 regulates chondrocyte proliferation, apoptosis and extracellular matrix synthesis by promoting the expression of miR-193b target gene IGF1R. Li BF, Zhang Y, Xiao J, Wang F, Li M, Guo XZ, Xie HB, Xia H, Chen B. Hum Cell. 2017 hsa_circ_0045714 expression was downregulated in OA tissues. qRT-PCR OA tissues and chondrocytes hsa_circ_0045714 can regulate extracellular matrix synthesis as well as proliferation and apoptosis of chondrocytes by promoting the expression of miR-193b target gene IGF1R. loss of function, gain of function chondrocytes OA cartilage was isolated from the knee joints of 20 patients undergoing total knee arthroplasty (12 men and 8 women; age range 45¨C58 years), and normal articular cartilage was isolated from the knee joints of 10 trauma patients (4 men and 6 women; age range 33¨C56 years) hsa_circ_0046677 circRNA homo sapiens TYMS hsa_circ_0046677 ATCTTCCTCTGATGGCGCTGCCTCCATGCCATGCCCTCTGCCAGTTCTATGTGGTGAACAGTGAGCTGTCCTGCCAGCTGTACCAGAGATCGGGAGACATGGGCCTCGGTGTGCCTTTCAACATCGCCAGCTACGCCCTGCTCACGTACATGATTGCGCACATCACGGGCCTGAAGCCAGGTGACTTTATACACACTTTGGGAGATGCACATATTTACCTGAATCACATCGAGCCACTGAAAATTCAG osteosarcoma 29229385 Circular RNA hsa_circ_0001564 regulates osteosarcoma proliferation and apoptosis by acting miRNA sponge. Song YZ, Li JF. Biochem Biophys Res Commun. 2018 upregulated microarray, qRT-PCR OS tissues and adjacent non-tumor tissues, NHOst, MG63, Saos-2, HOS, and U2OS hsa_circ_0046701 circRNA homo sapiens YES1 hsa_circ_0046701 GTGGTGTTACTATATTTGTGGCCTTATATGATTATGAAGCTAGAACTACAGAAGACCTTTCATTTAAGAAGGGTGAAAGATTTCAAATAATTAACAATACGGAAGGAGATTGGTGGGAAGCAAGATCAATCGCTACAGGAAAGAATGGTTATATCCCGAGCAATTATGTAGCGCCTGCAGATTCCATTCAGGCAGAAGAATGGTATTTTGGCAAAATGGGGAGAAAAGATGCTGAAAGATTACTTTTGAATCCTGGAAATCAACGAGGTATTTTCTTAGTAAGAGAGAGTGAAACAACTAAAGGTGCTTATTCCCTTTCTATTCGTGATTGGGATGAGATAAGGGGTGACAATGTGAAACACTACAAAATTAGGAAACTTGACAATGGTGGATACTATATCACAACCAGAGCACAATTTGATACTCTGCAGAAATTGGTGAAACACTACACAG glioma 29337055 A novel circular RNA, hsa_circ_0046701, promotes carcinogenesis by increasing the expression of miR-142-3p target ITGB8 in glioma. Li G, Yang H, Han K, Zhu D, Lun P, Zhao Y. Biochem Biophys Res Commun. 2018 significantly upregulated in glioma tissues and cell lines qRT-PCR Normal human astrocytes (NHAs) and glioma cell lines (U251, U373, and SHG44), glioma tissues and corresponding adjacent normal tissues Knockdown of hsa_circ_0046701 significantly decreased the cell viability, as assessed by the MTT assay, markedly reduced the number of colonies in the colony formation assay, and remarkably attenuated the invasive ability of the cells in the Transwell assay. loss of function U251 and U373 miR-142-3p circRNA-miRNA HEK-293T luciferase reporter assay The results showed that transfection of miR-142-3p mimics significantly attenuated the activity of the luciferase reporter containing wild-type (WT) hsa_circ_0046701 compared with the miR-142-3p mimics control. ITGB8 hsa_circ_0047905 circRNA homo sapiens SERPINB5 hsa_circ_0047905 GAGTTCATCAGCTCTACGAAGAGACCGTATGCAAAGGAATTGGAAACTGTTGACTTCAAAGATAAATTGGAAGAAACGAAAGGTCAGATCAACAACTCAATTAAGGATCTCACAGATGGCCACTTTGAGAACATTTTAGCTGACAACAGTGTGAACGACCAGACCAAAATCCTTGTGGTTAATGCTGCCTACTTTGTTGGCAAGTGGATGAAGAAATTTTCTGAATCAGAAACAAAAGAATGTCCTTTCAGAGTCAACAAGACAGACACCAAACCAGTGCAGATGATGAACATGGAGGCCACGTTCTGTATGGGAAACATTGACAGTATCAATTGTAAGATCATAGAGCTTCCTTTTCAAAATAAGCATCTCAGCATGTTCATCCTACTACCCAAGGATGTGGAGGATGAGTCCACAGGCTTGGAGAAGATTGAAAAACAACTCAACTCAGAGTCACTGTCACAGTGGACTAATCCCAGCACCATGGCCAATGCCAAGGTCAAACTCTCCATTCCAAAATTTAAGGTGGAAAAGATGATTGATCCCAAGGCTTGTCTGGAAAATCTAGGGCTGAAACATATCTTCAGTGAAGACACATCTGATTTCTCTGGAATGTCAGAGACCAAGGGAGTGGCCCTATCAAATGTTATCCACAAAGTGTGCTTAGAAATAACTGAAGATGGTGGGGATTCCATAGAGGTGCCAGGAGCACGGATCCTGCAGCACAAGGATGAATTGAATGCTGACCATCCCTTTATTTACATCATCAGGCACAACAAAACTCGAAACATTATTTTCTTTGGCAAATTCTGTTCTCCTTAAGTGGCATAGCCCATGTTAAGTCCTCCCTGACTTTTCTGTGGATGCCGATTTCTGTAAACTCTGCATCCAGAGATTCATTTTCTAGATACAATAAATTGCTAATGTTGCTGGATCAGGAAGCCGCCAGTACTTGTCATATGTAGCCTTCACACAGATAGACCTTTTTTTTTTTTCCAATTCTATCTTTTGTTTCCTTTTTTCCCATAAGACAATGACATACGCTTTTAATGAAAAGGAATCACGTTAGAGGAAAAATATTTATTCATTATTTGTCAAATTGTCCGGGGTAGTTGGCAGAAATACAGTCTTCCACAAAGAAAATTCCTATAAGGAAGATTTGGAAGCTCTTCTTCCCAGCACTATGCTTTCCTTCTTTGGGATAGAGAATGTTCCAGACATTCTCGCTTCCCTGAAAGACTGAAGAAAGTGTAGTGCATGGGACCCACGAAACTGCCCTGGCTCCAGTGAAACTTGGGCACATGCTCAGGCTACTATAGGTCCAGAAGTCCTTATGTTAAGCCCTGGCAGGCAGGTGTTTATTAAAATTCTGAATTTTGGGGATTTTCAAAAGATAATATTTTACATACACTGTATGTTATAGAACTTCATGGATCAGATCTGGGGCAGCACCCTATAAATCAACACCTTAATATGCTGCAACAAAATGTAGAATATTCAGACAAAATGGATACATAAAGACTAAGTAGCCCATAAGGGGTCAAAATTTGCTGCCAAATGCGTATGCCACCAACTTACAAAAACACTTCGTTCGCAGAGCTTTTCAGATTGTGGAATGTTGGATAAGGAATTATAGACCTCTAGTAGCTGAAATGCAAGACCCCAAGAGGAAGTTCAGATCTTAATATAAATTCACTTTCATTTTTGATAGCTGTCCCATCTGGTCATTTGGTTGGCACTAGACTGGTGGCAGGGGCTTCTAGCTGACTTGCACAGGGATTCTCACAATAGCCGATATCAGAATTTGTGTTGAAGGAACTTGTCTCTTCATCTAATATGATAGCGGGAAAAGGAGAGGAAACTACTGCCTTTAGAAAATATAAGTAAAGTGATTAAAGTGCTCACGTTACCTTGACACATAGTTTTTCAGTCTATGGGTTTAGTTACTTTAGATGGCAAGCATGTAACTTATATTAATAGTAATTTGTAAAGTTGGTTGGATAAGCTATCCGTGTTGCAGGTTCATGGATTACTTCTCTATAAAAAATATGTATTTACCAAAAATTTTGTGACATTCCTTCTCCCATCTCTTCCTTGACCTGCATTGTAAATAGGTTCTTCTTGTTCTGAGATTCAATATTGAATTTTTCCTATGCTATTGACAATAAAATATTATTGAACTACA gastric cancer 28980874 Analysis of co-expression networks for circular RNAs and mRNAs reveals that circular RNAs hsa_circ_0047905, hsa_circ_0138960 and has-circRNA7690-15 are candidate oncogenes in gastric cancer. Lai Z, Yang Y, Yan Y, Li T, Li Y, Wang Z, Shen Z, Ye Y, Jiang K, Wang S. Cell Cycle. 2017 upregulated in GC tissues compared with noncancerous tissue microarray, qRT-PCR GC tissues and noncancerous tissue, AGS Depletion of circRNA0047905 suppressed AGS cell proliferation and invasion in vitro.circRNA0047905 had the highest diagnostic accuracy, with an area under the curve (AUC) of 0.85 (95% CI: 0.751-0.950). loss of function AGS GC tissues hsa_circ_0048232 circRNA homo sapiens DAZAP1 hsa_circ_0048232 GAAGCTCTTCGTGGGCGGTCTTGACTGGAGCACGACCCAAGAGACTCTGCGCAGCTACTTTTCCCAATATGGAGAAGTCGTAGATTGTGTTATCATGAAAGATAAAACCACCAACCAGTCTCGAGGCTTTGGGTTTGTCAAATTTAAAGACCCAAACTGTGTGGGGACGGTGCTGGCCAGCAGACCGCACACGCTAGATGGCCGAAACATCGACCCCAAGCCATGCACACCCCGGGGGATGCAGCCGGAGAGAACACGGCCGAAGGAAGGATGGCAGAAAGGACCCAGGAGCGATAACAGTAAATCAAATAAGATATTTGTCGGTGGAATTCCTCACAATTGTGGTGAGACAGAGCTCAGGGAATACTTCAAGAAGTTCGGAGTGGTCACGGAGGTAGTCATGATCTATGACGCCGAGAAGCAGAGGCCCCGAG Colorectal cancer 28656150 Microarray Analysis of Circular RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells. Xiong W, Ai YQ, Li YF, Ye Q, Chen ZT, Qin JY, Liu QY, Wang H, Ju YH, Li WH, Li YF. Biomed Res Int. 2017 down microarray, qRT-PCR CRR (chemoradiation resistance)-HCT116 and the parental HCT116 cells hsa_circ_0049983 circRNA homo sapiens GTPBP3 hsa_circ_0049983 GTGTGGGGACCCGTCCACAGATCCCCCGCTGCTGACCCGAGCAAGGCACCAGCACCACCTCCAGGGTTGCCTGGATGCCCTCGGCCACTACAAGCAGTCAAAAGACCTGGCCCTGGCGGCAGAGGCGCTGCGGGTGGCCCGGGGTCACCTGACCCGGCTCACAGGTGGAGGGGGTACCGAGGAGATCCTGGACATCATCTTCCAGGACTTCTGTGTGGGCAAGTGACGGGATCCAGGGAAGTCGCACCCAAGCTGCGTGGAGACCCAGGAGCCTCGGGGGATCTGGAAACAGTTTAGGCCAATTGGGATTCTCATTCGCCTGGGAAAGAACTTGATTCTCAAATAGTGAAGCAACACAGCTGAGAGGTAGTGAGATCCCTGCAGGGACTCCCTGGAGATTCAGGCCCTGGAATGGGGCTGAATGGAGGTCCCGTTCGACCCTTGATGCTGGGGCATCCGGGTTGGGATGGAGATAGGAGGATCTCAGTATATTTGTTTCGTAGTTTTTTATTTATTTTGCAAATACCAAAGGAATGTAAAAAAAACTCAGGTGATCTAGAAGTGTTTATTTTCTTCCCTTCCCTTCCCTTCCCTTTCCTTTTCCCTTTCCCTTTCCCCTTCCCCTTCCCCTTCCCCTTCCCCTACCCTTCCCTCCTCTGTCTATTGCCCAGGCTGGAGTGCAGTGGTGCGACCTTGGCTCACTGCAACCTCCATCTCCGGGGCTCAAGCGCTTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGCATGTGCCAGCATGCCCGGCTAATTTTTTTCTTTTTTTGAGACAGAGTCTCGCTCTGTCACCCAGGCTGGAGTTCAGTGGTGCGACCTCGGCTTACTGCAACCTCCACCTCCCGGGTTCAAGTGATTCTCCTGCCTCAGCCTCTTGAGTAGCTGGGACTACAGGCGCACACCACCACGCCAGGCTAATTTTTGTATTTTTAGTAGAGACAAGGTTTCACCATGTTGACCAGGCTGGTCTTGAACTCCTTGACCTCAGGTAATCTGCCTACCTTGGCCTCCCAAAGTGCTGGGATCACAGGCGTGAGCTATCACACCTGGCCCCAGAAGTGTTTCAACATGGAAATTTTCCTTAGCCCTTCTGTGGTTGTCATGGCTTAATGTGTGTCTTTCCAGAACTTTGAATGTTTGCATACTTGTGGATGTACCTTTCAAATATGTTTGTCTTGTGTATCATATATAAATGGTATTGTGTTCATTGCTCTA endometrial cancer 29334253 Circular RNA expression in extracellular vesicles isolated from serum of patients with endometrial cancer. Xu H, Gong Z, Shen Y, Fang Y, Zhong S. Epigenomics. 2018 down RNA-seq, northern blots extracellular vesicles isolated from serum of patients with endometrial cancer hsa_circ_0051660 circRNA homo sapiens SAE1 hsa_circ_0051660 GTAACTCCAGAAGATCCCGGAGCTCAGTTCTTGATTCGTACTGGGTCTGTTGGCCGAAATAGGGCTGAAGCCTCTTTGGAGCGAGCTCAGAATCTCAACCCCATGGTGGATGTGAAGGTGGACACTGAGGATATAGAGAAGAAACCAGAGTCATTTTTCACTCAATTCGATGCTGTGTGTCTGACTTGCTGCTCCAGGGATGTCATAGTTAAAGTTGACCAGATCTGTCACAAAAATAGCATCAAGTTCTTTACAGGAGATGTTTTTGGCTACCATGGATACACATTTGCCAATCTAGGAGAGCATGAGTTTGTAGAGGAGAAAACTAAAGTTGCCAAAGTTAGCCAAGGAGTAGAAGATGGGCCCGACACCAAGAGAGCAAAACTTGATTCTTCTGAGACAACGATGGTCAAAAAG male infertile diseases 27958373 Identification and characterization of human testis derived circular RNAs and their existence in seminal plasma. Dong WW, Li HM, Qing XR, Huang DH, Li HG. Sci Rep. 2016 To validate these predicted circRNAs, 55 circRNAs of different abundance and lengths were randomly chosen for subsequent RT-PCR validation. Divergent primers were designed for circRNA detection. Among the 55 circRNAs, 30 of them could be specifically amplified. qRT-PCR human testis hsa_circ_0052858 circRNA homo sapiens PUM2 hsa_circ_0052858 GTTTGATCTGTGGATGAAATGAATCATGATTTTCAAGCTCTTGCATTAGAATCTCGGGGAATGGGAGAGCTTTTGCCTACCAAAAAGTTTTGGGAACCTGATGATTCAACAAAAGATGGACAAAAAGGCATATTTCTTGGGGATGATGAATGGAGAGAGACTGCATGGGGAGCTTCTCACCATTCAATGTCCCAGCCTATTATGGTACAGAGAAGATCTGGACAGGGTTTTCATGGAAACAGTGAAGTAAATGCAATACTGTCTCCGCGATCAGAAAGTGGAGGCCTTGGTGTGAGCATGGTAGAATATGTATTAAGTTCTTCTCCTGCTGATAAATTGGATTCTCGATTTAGGAAGGGAAATTTTGGCACTAGAGATGCTGAAACAGATGGACCTGAGAAAGGAGATCAAAAAGGCAAGGCTTCTCCATTTGAGGAGGACCAAAACAGAGATCTTAAACAAGGAGATGATGATGATTCTAAAATAAATGGCAGAGGTTTGCCAAATGGAATGGATGCCGATTGCAAAGATTTTAATCGTACTCCTGGAAGTCGTCAAGCCTCTCCAACTGAAGTAGTTGAGCGCTTGGGCCCCAATACTAATCCCTCAGAAGGACTGGGGCCTCTTCCTAATCCTACAGCTAATAAACCACTTGTTGAAGAATTTTCAAATCCTGAAACTCAGAATCTGGATGCCATGGAACAAGTTGGTCTGGAATCCTTACAGTTTGACTATCCTGGTAATCAGGTACCAATGGACTCTTCAGGAGCTACTGTAGGCCTTTTTGACTACAATTCCCAGCAGCAGCTCTTTCAGAGGACTAATGCACTAACAGTTCAACAGTTAACTGCAGCTCAACAGCAGCAATATGCATTAGCAGCAGCTCAGCAGCCACATATAGCTGGTGTATTCTCAGCAGGCCTTGCTCCAGCTGCATTTGTGCCAAATCCATACATTATTAGTGCTGCTCCTCCAGGGACCGATCCGTATACTGCAGCAGGATTGGCTGCAGCAGCTACATTAGCAGGTCCAGCAGTGGTTCCACCTCAGTATTACGGCGTTCCATGGGGGGTGTATCCAGCCAACTTATTTCAGCAGCAAGCTGCAGCTGCGGCAAATAACACAGCCAGTCAGCAAGCAGCATCACAAGCTCAGCCTGGACAGCAACAGGTTCTCCGTGCTGGAGCAGGTCAGCGTCCTCTTACTCCCAATCAGGGTCAGCAAGGGCAGCAAGCAGAATCACTTGCGGCAGCTGCAGCAGCAAATCCAACATTGGCTTTTGGTCAGGGTCTTGCTACTGGCATGCCAG osteosarcoma 29229385 Circular RNA hsa_circ_0001564 regulates osteosarcoma proliferation and apoptosis by acting miRNA sponge. Song YZ, Li JF. Biochem Biophys Res Commun. 2018 upregulated microarray, qRT-PCR OS tissues and adjacent non-tumor tissues, NHOst, MG63, Saos-2, HOS, and U2OS hsa_circ_0053958 circRNA homo sapiens CRIM1 hsa_circ_0053958 ATGAGAACTGGACTGATGACCAACTGCTTGGTTTTAAACCATGCAATGAAAACCTTATTGCTGGCTGCAATATAATCAATGGGAAATGTGAATGTAACACCATTCGAACCTGCAGCAATCCCTTTGAGTTTCCAAGTCAGGATATGTGCCTTTCAGCTTTAAAGAGAATTGAAGAAGAGAAGCCAGATTGCTCCAAGGCCCGCTGTGAAGTCCAGTTCTCTCCACGTTGTCCTGAAGATTCTGTTCTGATCGAGGGTTATGCTCCTCCTGGGGAGTGCTGTCCCTTACCCAGCCGCTGCGTGTGCAACCCCGCAGGCTGTCTGCGCAAAGTCTGCCAGCCGGGAAACCTGAACATACTAGTGTCAAAAGCCTCAGGGAAGCCGGGAGAGTGCTGTGACCTCTATGAGTGCAAACCAGTTTTCGGCGTGGACTGCAGGACTGTGGAATGCCCTCCTGTTCAGCAGACCGCGTGTCCCCCGGACAGCTATGAAACTCAAGTCAGACTAACTGCAGATGGTTGCTGTACTTTGCCAACAAGATGCGAGTGTCTCTCTGGCTTATGTGGTTTCCCCGTGTGTGAGGTGGGATCCACTCCCCGCATAGTCTCTCGTGGCGATGGGACACCTGGAAAGTGCTGTGATGTCTTTGAATGTGTTAATGATACAAAGCCAGCCTGCGTATTTAACAATGTGGAATATTATGATGGAGACATGTTTCGAATGGACAACTGTCGGTTCTGTCGATGCCAAGGGGGCGTTGCCATCTGCTTCACCGCCCAGTGTGGTGAGATAAACTGCGAGAGGTACTACGTGCCCGAAGGAGAGTGCTGCCCAGTGTGTGAAGATCCAGTGTATCCTTTTAATAATCCCGCTGGCTGCTATGCCAATGGCCTGATCCTTGCCCACGGAGACCGGTGGCGGGAAGACGACTGCACATTCTGCCAGTGCGTCAACGGTGAACGCCACTGCGTTGCGACCGTCTGCGGACAGACCTGCACAAACCCTGTGAAAGTGCCTGGGGAGTGTTGCCCTGTGTGCGAAGAACCAACCATCATCACAGTTGATCCACCTGCATGTGGGGAGTTATCAAACTGCACTCTGACAGGGAAGGACTGCATTAATGGTTTCAAACGCGATCACAATGGTTGTCGGACCTGTCAGTGCATAAACACCGAGGAACTATGTTCAGAACGTAAACAAGGCTGCACCTTGAACTGTCCCTTCGGTTTCCTTACTGATGCCCAAAACTGTGAGATCTGTGAGTGCCGCCCAAGGCCCAAGAAGTGCAGACCCATAATCTGTGACAAGTATTGTCCACTTGGATTGCTGAAGAATAAGCACGGCTGTGACATCTGTCGCTGTAAGAAATGTCCAGAGCTCTCATGCAGTAAGATCTGCCCCTTGGGTTTCCAGCAGGACAGTCACGGCTGTCTTATCTGCAAGTGCAGAGAGGCCTCTGCTTCAGCTGGGCCACCCATCCTGTCGGGCACTTGTCTCACCGTGGATGGTCATCATCATAAAAATGAGGAGAGCTGGCACGATGGGTGCCGGGAATGCTACTGTCTCAATGGACGGGAAATGTGTGCCCTGATCACCTGCCCGGTGCCTGCCTGTGGCAACCCCACCATTCACCCTGGACAGTGCTGCCCATCATGTGCAGATGACTTTGTGGTGCAGAAGCCAGAGCTCAGTACTCCCTCCATTTGCCACGCCCCTGGAGGAGAATACTTTGTGGAAGGAGAAACGTGGAACATTGACTCCTGTACTCAGTGCACCTGCCACAGCGGACGGGTGCTGTGTGAGACAGAGGTGTGCCCACCGCTGCTCTGCCAGAACCCCTCACGCACCCAGGATTCCTGCTGCCCACAGTGTACAG osteosarcoma 29229385 Circular RNA hsa_circ_0001564 regulates osteosarcoma proliferation and apoptosis by acting miRNA sponge. Song YZ, Li JF. Biochem Biophys Res Commun. 2018 upregulated microarray, qRT-PCR OS tissues and adjacent non-tumor tissues, NHOst, MG63, Saos-2, HOS, and U2OS hsa_circ_0054345 circRNA homo sapiens LRPPRC hsa_circ_0054345 AAATAAACGGTGACTGGCAAAGAGCTGATGCAGTCTGGAATAAAATCCAAGAAGAAAATGTTATTCCTCGTGAAAAGACATTAAGATTATTAGCAGAAATCCTTAGAGAGGGTAACCAGGAAGTTCCGTTTGACGTACCTGAGTTGTGGTATGAAGATGAAAAACATTCCCTGAATTCTTCGTCAGCCTCAACCACAGAACCTGATTTCCAGAAAGATATATTGATTGCCTGCCGATTGAACCAAAAAAAAGGGGCATATGATATTTTCCTGAATGCAAAAGAGCAAAACATTGTGTTTAATGCTGAAACCTACAGCAATCTCATTAAATTACTGATGTCAGAAGATTATTTTACACAAGCAATGGAAGTGAAAGCATT Radiation-induced liver fibrosis 28774651 Microarray profiling of circular RNAs and the potential regulatory role of hsa_circ_0071410 in the activated human hepatic stellate cell induced by irradiation. Chen Y, Yuan B, Wu Z, Dong Y, Zhang L, Zeng Z. Gene. 2017 significantly up-regulated in irradiated HSC compared with normal HSC. qRT-PCR, microarray irradiated hepatic stellate cell (HSC) and normal HSC hsa_circ_0054633 circRNA homo sapiens PNPT1 hsa_circ_0054633 TCAGGTGACACTGCAGTAATGGTCACAGCGGTCAGTAAAACAAAACCTTCCCCTTCCCAGTTTATGCCTTTGGTGGTTGACTACAGACAAAAAGCTGCTGCAGCAGGTAGAATTCCCACAAACTATCTGAGAAGAGAGATTGGTACTTCTGATAAAGAAATTCTAACAAGTCGAATAATAGATCGTTCAATTAGACCGCTCTTTCCAGCTGGCTACTTCTATGATACACAGGTTCTGTGTAATCTGTTAGCAGTAGATGGTGTAAATGAGCCTGATGTCCTAGCAATTAATGGCGCTTCCGTAGCCCTCTCATTATCAGATATTCCTTGGAATGGACCTGTTGGGGCAGTACGAATAGGAATAATTGATGGAGAATATGTTGTTAACCCAACAAGAAAAGAAATGTCTTCTAGTACTTTAAATTTAGTGGTTGCTGGAGCACCTAAAAGTCAGATTGTCATGTTGGAAGCCTCTGCAGAGAACATTTTACAGCAGGACTTTTGCCATGCTATCAAAGTGGGAGTGAAATATACCCAACAAATAATTCAGGGCATTCAGCAGTTGGTAAAAGAAACTGGTGTTACCAAGAGGACACCTCAGAAGTTATTTACCCCTTCGCCAGAGATTGTGAAATATACTCATAAACTTGCTATGGAGAGACTCTATGCAGTTTTTACAGATTACGAGCATGACAAAGTTTCCAGAGATGAAGCTGTTAACAAAATAAGATTAGATACGGAGGAACAACTAAAAGAAAAATTTCCAGAAGCCGATCCATATGAAATAATAGAATCCTTCAATGTTGTTGCAAAGGAAGTTTTTAGAAGTATTGTTTTGAATGAATACAAAAGGTGCGATGGTCGGGATTTGACTTCACTTAGGAATGTAAGTTGTGAGGTAGATATGTTTAAAACCCTTCATGGATCAGCATTATTTCAAAGAGGACAAACACAGGTGCTTTGTACCGTTACATTTGATTCATTAGAATCTGGTATTAAGTCAGATCAAGTTATAACAGCTATAAATGGGATAAAAGATAAAAATTTCATGCTGCACTACGAGTTTCCTCCTTATGCAACTAATGAAATTGGCAAAGTCACTGGTTTAAATAGAAGAGAACTTGGGCATGGTGCTCTTGCTGAGAAAGCTTTGTATCCTGTTATTCCCCGAGATTTTCCTTTCACCATAAGAGTTACATCTGAAGTCCTAGAGTCAAATGGGTCATCTTCTATGGCATCTGCATGTGGCGGAAGTTTAGCATTAATGGATTCAGGGGTTCCAATTTCATCTGCTGTTGCAGGCGTAGCAATAGGATTGGTCACCAAAACCGATCCTGAGAAGGGTGAAATAGAAGATTATCGTTTGCTGACAGATATTTTGGGAATTGAAGATTACAATGGTGACATGGACTTCAAAATAGCTGGCACTAATAAAGGAATAACTGCATTACAGGCTGATATTAAATTACCTGGAATACCAATAAAAATTGTGATGGAGGCTATTCAACAAGCTTCAGTGGCAAAAAAGGAGATATTACAGATCATGAACAAAACTATTTCAAAACCTCGAGCATCTAGAAAAGAAAATGGACCTGTTGTAGAAACTGTTCAGGTTCCATTATCAAAACGAGCAAAATTTGTTGGACCTGGTGGCTATAACTTAAAAAAACTTCAGGCTGAAACAGGTGTAACTATTAGTCAGGTGGATGAAGAAACGTTTTCTGTATTTGCACCAACACCCAGTGCTATGCATGAGGCAAGAGACTTCATTACTGAAATCTGCAAGGATGATCAGGAGCAGCAATTAGAATTTGGAGCAGTATATACCGCCACAATAACTGAAATCAGAGATACTGGTGTAATGGTAAAATTATATCCAAATATGACTGCGGTACTGCTTCATAACACACAACTTGATCAACGAAAGATTAAACATCCTACTGCCCTAGGATTAGAAGTTGGCCAAGAAATTCAGGTGAAATACTTTGGACGTGACCCAGCCGATGGAAGAATGAGGCTTTCTCGAAAAGTGCTTCAGTCGCCAGCTACAACCGTGGTCAGAACTTTGAATGACAGAAGTAGTATTGTAATGGGAGAACCTATTTCACAGTCATCATCTAATTCTCAGTGATTTTTTTTTTTAAAGAGAATTCTAGAATTCTATTTTGTCTAGGGTGATGTGCTGTAGAGCAACATTTTAGTAGTATCTTCCATTGTGTAGATTTCTATATAATATAAATACATTTTAATTATTTGTACTAAAATGCTCATTTACATGTGCCATTTTTTTAATTCGAGTAACCCATATTTGTTTAATTGTATTTACATTATAAATCAAGAAATATTTATTATTAAAAGTAAGTCATTTATACATCTTAGAAAAAATTACATAGTTTTGTTTTTACAATTCTGAAATATATGAAAAACTTAGATAGAATATGTCATATGTTATTATAACAGATCTCTTCCTACATCTTATTTTTCTTCTTTGTATACAGTAGTGACAGTTTACCTTCAGTCATCCTACAGGTCACCTCTGTGCCCAACAACTTTACTTGCCTACAACGGTTCACAAACTGGAACAGGCCATATTCAAAGCCAGTGCCTATTTCTTCAGAACTGTTAACAGATATAGTGAGTTGAGGGAGCTAATCTGATACACTTTTGATAATATAATGCCTTTCAAATTAGTTACCAAATCATAAACAGAGTGGAATAAATATAAATGAGATTCTAACTAGGATGAATGTGGTAGTAATGATGTATATTTTTCAAATTTACCTAAACAGAAAGATTATTGGCTAAGGCAGGCGGATCATGAGATCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCGTCTCTACTAAAAGTGCAAAAATTAGCCGGGCGTGGTGGCGCATGCCTGTAATCCTAGCTACTCAGGAGGCTGAGGCAGAAGAATCACTTCAACCCAGGAGGTGGAGGTTGTAGTGAGCCGAGATTGCGCCATTGCACTCCAGCTCAGGCAACAAGAGCAAAACTCCGTCTCAAAAAAAAAAAAAAAATTGTTTACTTATCAAATTGAACTAGGTCAATTTGAATATGTGTATTGCTCTAATGTATGGAAGTTCTTAGTATAAGAGCTGAAGGATCATGACTTTCGGTTAATAGATGTTTGAAATAGATGTTTAGAGGTTACTGATACACATGTCAAGTTGTTCATTCCCATCATTTAAAATATCACCTTATAATTCCACAGAAAAGTAAATGGTATGTGGACGTCATAATTTAGAATGTGTAATCTTTTTTAAAATCTTATAAAAATACACTGGACTCAGTGGTACGTGCCTGTAGTCCCAGCTACTTGGAAGGCTGAAGTGGGAAGGTCACTAGAGCCCAGAAGTTCGACACTGTAGTGTGCAACAATCATACCTGTGAATAGCTACTGTACTCCAGCCTGGGCAACATAGCAGGACTCTTATCTCTAAAAAAAATTTTAAATCTTATAAAAATGTAGGTATATCTGGCCAGGCATGGTGGCTCACACCTGTAATCCCAACACTTTGGGAGGTCAAGGCGGGTAGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTGGCGGGCGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCTCTTGAACCTGGGAGGCAGAGGTGGCAGTGAGCTGAGATCGCACCACTGCACTCCAGCCTGGGCAAAAAGAGTAAAACTCCATCTCAAAAAAAAAAATGGTGGGCACAGAAGCTCATGCCTGTAATTCCAGCACTTTGGGAGGCCGAGGCGGGTGGATTACATGAGGTCAGGAATTCAAGACCAGCCTGGCCAACACGGTAAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGGCATGGTGGCAGGCACCTGTAATCCTAGCTACTCGGGAGGCTGAGGCAGGAGAATCACTTGAGCCTGGGAAATGGAGGTTGCAGTGAGCCGAGATTGCGCCATTGCACTCCAGCCTGGGCGACAGAGCAAGACTCCGTCTCCAGAAAAAAAAAAAAAAAAGGTAAATTCATGACTCAGGGTTAACTAGTTCATAAAATATTACAAATTTATCTGGCTAAACCAAAGATTTTTAAGTCAATAAACATTGATTATATATCTATTGTGTGTAAAATAGCATGTTAGGCAATGTTGATATACTTCTGAAATATTAAAGATTAATTGAAAATGAAAGATTAAATTTATTTGCTTTCTACACTT type 2 diabetes mellitus 27878383 Hsa_circ_0054633 in peripheral blood can be used as a diagnostic biomarker of pre-diabetes and type 2 diabetes mellitus. Zhao Z, Li X, Jian D, Hao P, Rao L, Li M. Acta Diabetol. 2017 significantly different among the three groups and increased gradually from the control group to the pre-diabetes group to the T2DM group. qRT-PCR, microarray peripheral blood of T2DM, pre-diabetes and control groups hsa_circ_0054971 circRNA homo sapiens SLC1A4 hsa_circ_0054971 AAACCTGTTTCCCTCCAATCTTGTGGTTGCAGCTTTCCGTACGTATGCAACCGATTATAAAGTCGTGACCCAGAACAGCAGCTCTGGAAATGTAACCCATGAAAAGATCCCCATAGGCACTGAGATAGAAGGGATGAACATTTTAGGATTGGTCCTGTTTGCTCTGGTGTTAGGAGTGGCCTTAAAGAAACTAGGCTCCGAAGGAGAAGACCTCATCCGTTTCTTCAATTCCCTCAACGAGGCGACGATGGTGCTGGTGTCCTGGATTATGTG gastric cancer 28831102 Circular RNAs expression profiles in human gastric cancer. Dang Y, Ouyang X, Zhang F, Wang K, Lin Y, Sun B, Wang Y, Wang L, Huang Q. Sci Rep. 2017 downregulated in GC microarray, qRT-PCR GC tissues and the pair-matched normal tissues hsa_circ_005538 circRNA homo sapiens hsa_circ_005538 pulmonary tuberculosis 29371930 Identification and comparison of novel circular RNAs with associated co-expression and competing endogenous RNA networks in pulmonary tuberculosis. Zhang X, Zhu M, Yang R, Zhao W, Hu X, Gan J. Oncotarget. 2017 Downregulated in PTB patients compared to healthy individuals. RNA-seq, qRT-PCR PTB patients, healthy individuals hsa_circ_0057093 circRNA homo sapiens PDK1 hsa_circ_0057093 GTATATCCAGAGTCTTCAGGAGCTTCTTGATTTTAAGGACAAAAGTGCTGAGGATGCTAAAGCTATTTATGAGTAAGTTCACTATTTTGACCCTATTCTTAAACCTATTATTAGGTCACTTGGGGGAAATTGGTTAACTTTTAGGTTTCTACTACTTTAGAACATGTGATATATGTGACTGTAGCAGCCCATACAGGCAGGACAAATAACAATCAGCAAATTTGACTAGGCATAAGAAATGCTTCGTGTTCCTCTTTAACAAAAGACAAAGTTCAGGTGTGATGATCAGTGGAAATGTAGGTGTGGCCTCAGTGCCAGTTGGACTGTTCACCTGGAGGGTGCATGCTCCTTCTAATGGACAACCACCTTCAGCCCCAGCTGATCTTTGCCATATGAAAATACTGCCCATATCATCTGATTGTTTTCTGATTTTAAAGGAAAGCTACAAGTCTAGATTTGTAATGTAAAATCTCTCACTTTTGAAAGATTGGTAACTAATTAAAACATTTTTTAAAACACAGAAGGCCTAGAAGAACATGGTTGCAGGTCTCTAGTTTATGCTGTATGGCCTGCAAGATGAT Diabetes Retinopathy 29288268 Identification and Characterization of Circular RNAs as a New Class of Putative Biomarkers in Diabetes Retinopathy. Zhang SJ, Chen X, Li CP, Li XM, Liu C, Liu BH, Shan K, Jiang Q, Zhao C, Yan B. Invest Ophthalmol Vis Sci. 2017 Downregulated in diabetic human retinas compared to nodiabetic retinas. microarray, qRT-PCR diabetic human retinas, nodiabetic retinas hsa_circ_0057093 circRNA homo sapiens PDK1 hsa_circ_0057093 GTATATCCAGAGTCTTCAGGAGCTTCTTGATTTTAAGGACAAAAGTGCTGAGGATGCTAAAGCTATTTATGAGTAAGTTCACTATTTTGACCCTATTCTTAAACCTATTATTAGGTCACTTGGGGGAAATTGGTTAACTTTTAGGTTTCTACTACTTTAGAACATGTGATATATGTGACTGTAGCAGCCCATACAGGCAGGACAAATAACAATCAGCAAATTTGACTAGGCATAAGAAATGCTTCGTGTTCCTCTTTAACAAAAGACAAAGTTCAGGTGTGATGATCAGTGGAAATGTAGGTGTGGCCTCAGTGCCAGTTGGACTGTTCACCTGGAGGGTGCATGCTCCTTCTAATGGACAACCACCTTCAGCCCCAGCTGATCTTTGCCATATGAAAATACTGCCCATATCATCTGATTGTTTTCTGATTTTAAAGGAAAGCTACAAGTCTAGATTTGTAATGTAAAATCTCTCACTTTTGAAAGATTGGTAACTAATTAAAACATTTTTTAAAACACAGAAGGCCTAGAAGAACATGGTTGCAGGTCTCTAGTTTATGCTGTATGGCCTGCAAGATGAT Diabetes Retinopathy 29288268 Identification and Characterization of Circular RNAs as a New Class of Putative Biomarkers in Diabetes Retinopathy. Zhang SJ, Chen X, Li CP, Li XM, Liu C, Liu BH, Shan K, Jiang Q, Zhao C, Yan B. Invest Ophthalmol Vis Sci. 2017 Downregulated in diabetic human retinas compared to nodiabetic retinas. microarray, qRT-PCR diabetic human retinas, nodiabetic retinas hsa_circ_0057096 circRNA homo sapiens PDK1 hsa_circ_0057096 CTTTACAGATACTGTGATACGGATCAGAAACCGACACAATGATGTCATTCCCACAATGGCCCAGGGTGTGATTGAATACAAGGAGAGCTTTGGGGTGGATCCTGTCACCAGCCAGAATGTTCAGTACTTTTTGGATCGATTCTACATGAGTCGCATTTCAATTAGAATGTTACTCAATCAGCACTCTTTATTGTTTGGTGGAAAAGGCAAAGGAAGTCCATCTCATCGAAAACACATTGGAAGCATAAATCCAAACTGCAATGTACTTGAAGTTATTAAAG hepatocellular carcinoma 29251325 CD90 promotes cell migration, viability and sphere-orming ability of hepatocellular carcinoma cells. Zhang K, Che S, Su Z, Zheng S, Zhang H, Yang S, Li W, Liu J. Int J Mol Med. 2018 Differentially expressed circRNAs between CD90+ and CD 90 cells microarray, qRT-PCR SK Hep 1 CD90+ and SK Hep 1 CD90 cells, HCC and non tumor tissues hsa_circ_0057104 circRNA homo sapiens PDK1 hsa_circ_0057104 CAAAATCACCAGGACAGCCAATACAAGTGGTTTATGTACCATCCCATCTCTATCACATGGTGTTTGAACTTTTCAAGAATGCAATGAGAGCCACTATGGAACACCATGCCAACAGAGGTGTTTACCCCCCTATTCAAGTTCATGTCACGCTGGGTAATGAGGATTTGACTGTGAAGATGAGTGACCGAGGAGGTGGCGTTCCTTTGAGGAAAATTGACAGACTTTTCAACTACATGTATTCAACTGCACCAAGACCTCGTGTTGAGACCTCCCGCGCAGTGCCTCTGGCTGGTTTTGGTTATGGATTGCCCATATCACGTCTTTACGCACAATACTTCCAAGGAGACCTGAAGCTGTATTCCCTAGAGGGTTACGGGACAGATGCAGTTATCTACATTAAG gastric cancer 28831102 Circular RNAs expression profiles in human gastric cancer. Dang Y, Ouyang X, Zhang F, Wang K, Lin Y, Sun B, Wang Y, Wang L, Huang Q. Sci Rep. 2017 downregulated in GC microarray, qRT-PCR GC tissues and the pair-matched normal tissues hsa_circ_0057336 circRNA homo sapiens TFPI hsa_circ_0057336 TTACAAAAGAAGGAACAAATGATGGTTGGAAGAATGCGGCTCATATTTACCAAGTCTTTCTGAACGCCTTCTGCATTCATGCATCCATGTTCTTTCTAGGATTGGATAGCATTTCATGCCTATGTTAATATTTGTGCTTTTGGCATTTCCTTAATATTTATATGTATACGTGATGCCTTTGATAGCATACTGCTAATAAAGTTTTAATATTTACATGCATAGTAAA hepatoblastoma 29414822 Expression Profiling Identifies Circular RNA Signature in Hepatoblastoma. Liu BH, Zhang BB, Liu XQ, Zheng S, Dong KR, Dong R. Cell Physiol Biochem. 2018 down microarray, qRT-PCR hepatoblastoma and adjacent normal liver samples hsa_circ_0058058 circRNA homo sapiens ATIC hsa_circ_0058058 CCTTATTTAGTGTCTCTGACAAAACCGGCCTTGTGGAATTTGCAAGAAACCTGACCGCTCTTGGTTTGAATCTGGTCGCTTCCGGAGGGACTGCAAAAGCTCTCAGGGATGCTGGTCTGGCAGTCAGAGATGTCTCTGAGTTGACGGGATTTCCTGAAATGTTGGGGGGACGTGTGAAAACTTTGCATCCTGCAGTCCATGCTGGAATCCTAGCTCGTAATATTCCAGAAGATAATGCTGACATGGCCAGACTTGATTTCAATCTTATAAGAGTTGTTGCCTGCAATCTCTATCCCTTTGTAAAGACAGTGGCTTCTCCAGGTGTAACTGTTGAGGAGGCTGTGGAGCAAATTGACATTGGTGGAGTAACCTTACTGAGAGCTGCAGCCAAAAACCACGCTCGAGTGACAGTGGTGTGTGAACCAGAGGACTATGTGGTGGTGTCCACGGAGATGCAGAGCTCCGAGAGTAAGGACACCTCCTTGGAGACTAGACGCCAGTTAGCCTTGAAG Acute myeloid leukemia 28282919 Characterization of hsa_circ_0004277 as a New Biomarker for Acute Myeloid Leukemia via Circular RNA Profile and Bioinformatics Analysis. Li W, Zhong C, Jiao J, Li P, Cui B, Ji C, Ma D. Int J Mol Sci. 2017 upregulated microarray, qRT-PCR BM samples from 113 AML patients and 12 healthy controls hsa_circ_0058106 circRNA homo sapiens FN1 hsa_circ_0058106 GAGGAAATAGCCCTGTCCAGGAGTTCACTGTGCCTGGGAGCAAGTCTACAGCTACCATCAGCGGCCTTAAACCTGGAGTTGATTATACCATCACTGTGTATGCTGTCACTGGCCGTGGAGACAGCCCCGCAAGCAGCAAGCCAATTTCCATTAATTACCGAACAGAAATTGACAAACCATCCCAGATGCAAGTGACCGATGTTCAGGACAACAGCATTAGTGTCAAGTGGCTGCCTTCAAGTTCCCCTGTTACTGGTTACAGAGTAACCACCACTCCCAAAAATGGACCAGGACCAACAAAAACTAAAACTGCAGGTCCAGATCAAACAGAAATGACTATTGAAGGCTTGCAGCCCACAGTGGAGTATGTGGTTAGTGTCTATGCTCAGAATCCAAGCGGAGAGAGTCAGCCTCTGGTTCAGACTGCAGTAACCA hypopharyngeal squamous cell carcinoma 28514762 Novel circular RNA expression profiles reflect progression of patients with hypopharyngeal squamous cell carcinoma. Cao S, Wei D, Li X, Zhou J, Li W, Qian Y, Wang Z, Li G, Pan X, Lei D. Oncotarget. 2017 up microarray, qRT-PCR Tumor tissues and paired adjacent normal tissues miR-185-3p circRNA-miRNA Nasopharyngeal carcinoma validted in other papers (PMID:26390174 and 25297925) hsa_circ_0058107 circRNA homo sapiens FN1 hsa_circ_0058107 CTGTTCCTCCTCCCACTGACCTGCGATTCACCAACATTGGTCCAGACACCATGCGTGTCACCTGGGCTCCACCCCCATCCATTGATTTAACCAACTTCCTGGTGCGTTACTCACCTGTGAAAAATGAGGAAGATGTTGCAGAGTTGTCAATTTCTCCTTCAGACAATGCAGTGGTCTTAACAAATCTCCTGCCTGGTACAGAATATGTAGTGAGTGTCTCCAGTGTCTACGAACAACATGAGAGCACACCTCTTAGAGGAAGACAGAAAACAGGTCTTGATTCCCCAACTGGCATTGACTTTTCTGATATTACTGCCAACTCTTTTACTGTGCACTGGATTGCTCCTCGAGCCACCATCACTGGCTACAGGATCCGCCATCATCCCGAGCACTTCAGTGGGAGACCTCGAGAAGATCGGGTGCCCCACTCTCGGAATTCCATCACCCTCACCAACCTCACTCCAGGCACAGAGTATGTGGTCAGCATCGTTGCTCTTAATGGCAGAGAGGAAAGTCCCTTATTGATTGGCCAACAATCAACAGTTTCTGATGTTCCGAGGGACCTGGAAGTTGTTGCTGCGACCCCCACCAGCCTACTGATCAGCTGGGATGCTCCTGCTGTCACAGTGAGATATTACAGGATCACTTACGGAGAGACAGGAGGAAATAGCCCTGTCCAGGAGTTCACTGTGCCTGGGAGCAAGTCTACAGCTACCATCAGCGGCCTTAAACCTGGAGTTGATTATACCATCACTGTGTATGCTGTCACTGGCCGTGGAGACAGCCCCGCAAGCAGCAAGCCAATTTCCATTAATTACCGAACAGAAATTGACAAACCATCCCAGATGCAAGTGACCGATGTTCAGGACAACAGCATTAGTGTCAAGTGGCTGCCTTCAAGTTCCCCTGTTACTGGTTACAGAGTAACCACCACTCCCAAAAATGGACCAGGACCAACAAAAACTAAAACTGCAGGTCCAGATCAAACAGAAATGACTATTGAAGGCTTGCAGCCCACAGTGGAGTATGTGGTTAGTGTCTATGCTCAGAATCCAAGCGGAGAGAGTCAGCCTCTGGTTCAGACTGCAGTAACCA hypopharyngeal squamous cell carcinoma 28514762 Novel circular RNA expression profiles reflect progression of patients with hypopharyngeal squamous cell carcinoma. Cao S, Wei D, Li X, Zhou J, Li W, Qian Y, Wang Z, Li G, Pan X, Lei D. Oncotarget. 2017 up microarray, qRT-PCR Tumor tissues and paired adjacent normal tissues miR-185-3p circRNA-miRNA Nasopharyngeal carcinoma validted in other paper (PMID:26390174) hsa_circ_0058246 circRNA homo sapiens VIL1 hsa_circ_0058246 GAGGTCACAAGCCCCAAAGTGGACGTGTTCAATGCTAACAGCAACCTCAGTTCTGGGCCTCTGCCCATCTTCCCCCTGGAGCAGCTAGTGAACAAGCCTGTAGAGGAGCTCCCCGAGGGTGTGGACCCCAGCAGGAAGGAG gastric cancer 28639908 Circular RNAs play an important role in late-stage gastric cancer: Circular RNA expression profiles and bioinformatics analyses. Fang Y, Ma M, Wang J, Liu X, Wang Y. Tumour Biol. 2017 upregulated in GC microarray, qRT-PCR III stage gastric cancer and paired paracarcinoma tissue The patients who suffered recurrence of gastric cancer have a statistically significant increase in the expression of hsa_circ_0058246. III stage gastric cancer and paired paracarcinoma tissue hsa_circ_0058766 circRNA homo sapiens DGKD hsa_circ_0058766 TGTGCAAATTTAAGGCCCACAAGCGCTGTGCTGTGCGTGCAACCAATAACTGCAAGTGGACCACACTGGCCTCGATCGGGAAGGACATCATTGAAGATGCAGATGGGATTGCAATGCCCCACCAGTGGTTGGAAGGAAACCTACCTGTGAGCGCCAAGTGCACTGTGTGCGACAAGACCTGTGGCAGTGTGCTGCGCCTGCAGGACTGGCGCTGCCTCTGGTGCAAGGCCATGGTTCACACATCGTGTAAAGAATCCTTGCTGACCAAGTGCCCACTTGGCCTGTGCAAAGTGTCAGTCATCCCACCCACGGCTCTCAACAGCATCGACTCCGATG gastric cancer 28831102 Circular RNAs expression profiles in human gastric cancer. Dang Y, Ouyang X, Zhang F, Wang K, Lin Y, Sun B, Wang Y, Wang L, Huang Q. Sci Rep. 2017 downregulated in GC microarray, qRT-PCR GC tissues and the pair-matched normal tissues hsa_circ_0060108 circRNA homo sapiens FER1L4 hsa_circ_0060108 GCTTTCCATTCGCAGACCCTCCCCTTTATGGCCACCCGGATAGGCACCTTCAGGATGGACCTGGGCATCATCTTGGACCAGCCAGATGGCCAGTTCTACCAAAGATGGGTTCCGCTGCATGATCCCCGAGACACCCGCGCCGGGACCAAGGGTTTCATTAAGGTCACCTTGTCCGTGAGGGCGCGCGGGGACCTGCCCCCTCCAATGCTACCCCCGGCCCCAGGGCACTGTTCGGACATCGAGAAGAACCTGCTCCTGCCGCGCGGGGTGCCCGCCGAGAGGCCATGGGCGCGGCTCCGCGTGCGCCTGTACCGCGCCGAGGGGCTTCCCGCGCTGCGCCTGGGGCTGCTGGGCAGCCTGGTCCGCGCCCTGCACGACCAGCGCGTCCTGGTGGAGCCCTATGTGCGGGTGTCTTTCCTGGGGCAGGAGGGCGAGACGTCGGTGAGCGCCGAGGCGGCGGCGCCCGAATGGAACGAGCAGCTGAGCTTCGTGGAGCTCTTCCCGCCGCTGACGCGCAGCCTCCGCCTGCAGCTGCGGGACGACGCGCCCCTGGTCGACGCGGCACTCGCTACGCACGTGCCGGACCTGAGGCGGATCTCCCATCCGGGCCGCGCGGCGGGGTTTAACCCTACCTTCGGCCCGGCCTGGGTGCCCCTCTATGGCTCGCCCCCCGGCGCGGGGCTCCGGGATAGTCTTCAAGGTCTCAACGAAGGCGTTGGCCAAGGCATTTGGTTCCGCGGCCGCCTTCTGCTGGCTGTGTCCATGCAGGTGTTGGAAGGGAGAGCTGAACCTGAGCCTCCCCAGGCCCAGCAGGGGTCCACGTTGTCCCGGCTCACCCGAAAGAAGAAAAAGAAAGCCAGAAGGGATCAGACCCCAAAGGCGGTTCCGCAGCACTTGGACGCCAGCCCCGGTGCCGAGGGGCCTGAGATCCCCCGTGCCATGGAGGTGGAGGTGGAGGAGCTGCTGCCGCTGCCAGAGAATGTCCTGGCGCCCTGTGAAGATTTCCTGCTTTTCGGTGTGCTCTTCGAGGCCACCATGATCGACCCCACCGTGGCCTCCCAGCCCATCAGCTTCGAGATCTCCATTGGTCGCGCAGGCCGTCTGGAGGAGCAATTGGGCCGAGGGTCCAGGGCTGGGGAGGGAACTGAGGGTGCAGCCGTGGAGGCTCAGCCTCTGCTGGGAGCCAGGCCAGAGGAGGAGAAAGAGGAGGAAGAACTGGGGACCCATGCTCAGCGGCCTGAGCCCATGGACGGCAGTGGGCCATACTTCTGCTTGCCCCTCTGTCACTGCAAGCCATGCATGCATGTGTGGAGTTGCTGGGAGGACCACACCTGGCGCCTGCAGAGCAGCAACTGCGTGCGCAAAGTGGCCGAGAGGCTGGACCAGGGGCTGCAGGAGGTTGAGAGACTGCAGCGCAAGCCGGGGCCTGGCGCCTGTGCACAGCTCAAGCAGGCACTGGAAGTACTGGTGGCTGGGAGCAGACAGTTTTGCCACGGTGCCGAGCGCAGGACGATGACCCGGCCCAATGCCCTGGATCGATGCCGAGGGAAACTCCTGGTGCACAGCCTGAACCTTTTGGCTAAGCAAGGACTGCGACTTCTACGCGGCCTGAGACGGCGCAATGTGCAAAAGAAGGTGGCACTGGCCAAGAAGCTCCTGGCAAAACTGCGCTTTCTGGCTGAGGAGCCCCAGCCACCCCTCCCCGATGTGCTGGTCTGGATGCTCAGCGGGCAGCGCCGTGTGGCCTGGGCCCGGATCCCTGCCCAGGATGTGCTGTTCTCTGTGGTTGAGGAGGAACGGGGCCGAGACTGTGGGAAGATCCAGAGTCTAATGCTCACGGCACCCGGGGCAGCCCCTGGTGAGGTCTGTGCCAAGCTGGAGCTCTTCCTGCGGCTGGGCCTGGGCAAGCAAGCCAAGGCCTGCACCTCTGAGCTGCCCCCGGATTTGCTGCCCGAGCCCTCAGCCGGGCTGCCCTCCAGCCTACACCGGGACGGTCCTGGAGCAGACGCTGAGCCCTCTGTGGGATGAACTCCTGGTATTTGAGCAGTTGATCGTGGATGGGAGGAGGGAGCACCTGCAGGAGGAGCCTCCATTAGTGATCATCAATGTATTTGACCACAATAAGTTTCCCTCAGTGCCCAGTGAGGTGGAGCCCCAGGATCTGGCACCCCTGGTTGAGCCCCACTCTGGACGCCTGTCCCTTCCACCCAACGTGTGCCCAGTGCTCAGGGAGTTCCGTGTTGAGGTGCTGTTCTGGGGTCTTAGGGGACTTGGTCGTGTGCATCTGCTCGAGGTGGAGCAGCCCCAGGTTGTACTGGAGGTGGCTGGGCAAGGTGTGGAGTCTGAGGTCCTGGCCAGCTACCGTGAGAGCCCCAATTTCACTGAGCTTGTCAGGCATCTGACAGTGGACTTGCCGGAGCAGCCTTACTTGCAGCCTCCACTCAGCATCTTGGTGATTGAGCGCCGGGCCTTTGGCCACACAGTCCTTGTGGGTTCCCACATTGTCCCCCACATGCTGCGATTCACATTTCGGGGTCATGAGGATCCTCCTGAGGAGGAAGGAGAGATGGAGGAGACAGGGGATATGATGCCCAAGGGACCTCAAGGACAGAAGTCCCTGGATCCCTTCTTGGCTGAAGCGGGTATATCCAGACAGCTCCTGAAG gastric cancer 28831102 Circular RNAs expression profiles in human gastric cancer. Dang Y, Ouyang X, Zhang F, Wang K, Lin Y, Sun B, Wang Y, Wang L, Huang Q. Sci Rep. 2017 downregulated in GC microarray, qRT-PCR GC tissues and the pair-matched normal tissues circCYP24A1 circRNA homo sapiens CYP24A1 hsa_circ_0060927 GGAAGGGGAAGACTGGCAGCGGGTCCGGAGTGCCTTTCAAAAGAAACTAATGAAACCAGGGGAAGTGATGAAGCTGGACAACAAAATCAATGAGGTCTTGGCCGATTTTATGGGCAGAATAGATGAGCTCTGTGATGAAAGAGGCCACGTTGAAGACTTGTACAGCGAACTGAACAAATGGTCGTTTGAAAGTATCTGCCTCGTGTTGTATGAGAAGAGATTTGGGCTTCTCCAGAAGAATGCAGGGGATGAAGCTGTGAACTTCATCATGGCCATCAAAACAATGATGAGCACGTTTGGGAGGATGATGGTCACTCCAGTCGAGCTGCACAAGAGCCTCAACACCAAGGTCTGGCAGGACCACACTCTGGCCTGGGACACCATTTTCAAATCAGTCAAAGCTTGTATCGACAACCGGTTAGAGAAGTATTCTCAGCAGCCTAGTGCAGATTTCCTTTGTGACATTTATCACCAGAATCGGCTTTCAAAGAAAGAATTGTATGCTGCTGTCACAGAGCTCCAGCTGGCTGCGGTGGAAACGACAGCAAACAGTCTAATGTGGATTCTCTACAATTTATCCCGTAATCCCCAAGTGCAACAAAAGCTTCTTAAGGAAATTCAAAGTGTATTACCTGAGAATCAGGTGCCACGGGCAGAAGATTTGAGGAATATGCCGTATTTAAAAGCCTGTCTGAAAGAATCTATGAGGCTTACGCCGAGTGTACCATTTACAACTCGGACTCTTGACAAGGCAACAGTTCTGGGTGAATATGCTTTACCCAAAGGAACAGTGCTCATGCTAAATACCCAGGTGTTGGGATCCAGTGAAGACAATTTTGAAGATTCAAGTCAGTTTAGACCTGAACGTTGGCTTCAGGAGAAGGAAAAAATTAATCCTTTTGCGCATCTTCCATTTGGCGTTGGAAAAAGAATGTGCATTGGTCGCCGATTAGCAGAGCTTCAACTGCATTTGGCTCTTTGTTGGATTGTCCGCAAATACGACATCCAGGCCACAGACAATGAGCCTGTTGAGATGCTACACTCAGGCACCCTGGTGCCCAGCCGGGAACTCCCCATCGCGTTTTGCCAGCGATAATACGCCTCAG 24039610 Cell-type specific features of circular RNA expression. Salzman J, Chen RE, Olsen MN, Wang PL, Brown PO. PLoS Genet. 2013 HeLa RNA was treated with RNase R or a mock treatment, and then subjected to qPCR with isoform-specific primers. The fraction of linear and circular isoforms was normalized to the value measured in the mock treatment. All tested circular isoforms resisted RNase R. qRT-PCR HeLa hsa_circ_0061274 circRNA homo sapiens NRIP1 hsa_circ_0061274 ATGCACACTTGACTGAAGGAGGACAGGGAATCTGAAGACTCCGGATGACATCAGAGCTACTTTTCAACAGCCTTCTCAATTTTCTTTCTCAGAAAGCAGAGGCTCAGAGCTTGGAGACAGACG gastric cancer 28737829 Expression profile of circular RNAs in human gastric cancer tissues. Huang YS, Jie N, Zou KJ, Weng Y. Mol Med Rep. 2017 upregulated microarray, qRT-PCR GC tissues and adjacent normal tissues hsa_circ_0061276 circRNA homo sapiens NRIP1 hsa_circ_0061276 GAAGTGTTTGGATTGTGAGCTATTTCAGAACTGTTCTCAGGACTCATTATTTTAACATTTGGGAGAAACACAGCCAGAAG Gastric cancer 29098316 Plasma circular RNA profiling of patients with gastric cancer and their droplet digital RT-PCR detection. Li T, Shao Y, Fu L, Xie Y, Zhu L, Sun W, Yu R, Xiao B, Guo J. J Mol Med (Berl). 2018 down microarray, RT-ddPCR gastric cancer tissues and their adjacent non-tumorous tissues, and gastric cancer patients¡¯ plasma and healthy controls, BGC-823, MGC-803, SGC-7901 and GES-1 Hsa_circ_0001017 and hsa_circ_0061276 can be prognostic indicators of gastric cancer. gastric cancer tissues and their adjacent non-tumorous tissues, and gastric cancer patients plasma and healthy controls hsa_circ_0061893 circRNA homo sapiens PDXK hsa_circ_0061893 GTTTTGGGATTTGAGATTGACGCGGTGAACTCTGTCCAGTTTTCAAACCACACAGGCTATGCCCACTGGAAGGGCCAAGTGCTGAATTCAGATGAGCTCCAGGAGTTGTACGAAGGCCTGAGGCTGAACAACATGAATAAATATGACTACGTGCTCACAGGTTATACGAGGGACAAGTCGTTCCTGGCCATGGTGGTGGACATTGTGCAGGAGCTGAAGCAGCAGAACCCCAGGCTGGTGTACGTGTGTGATCCAGTCTTGGGTGACAAGTGGGACGGCGAAGGCTCGATGTACGTCCCGGAGGACCTCCTTCCCGTCTACAAAGAAAAAGTGGTGCCGCTTGCAGACATTATCACGCCCAACCAGTTTGAGGCCGA Radiation-induced liver fibrosis 28774651 Microarray profiling of circular RNAs and the potential regulatory role of hsa_circ_0071410 in the activated human hepatic stellate cell induced by irradiation. Chen Y, Yuan B, Wu Z, Dong Y, Zhang L, Zeng Z. Gene. 2017 significantly down-regulated in irradiated HSC compared with normal HSC. qRT-PCR, microarray irradiated hepatic stellate cell (HSC) and normal HSC hsa_circ_0062163 circRNA homo sapiens CECR2 hsa_circ_0062163 TGAAAAGCAGGAAGAAAATTCCTTGGCATCCGAGCCACAGACAAGACATGGGTCCCAAGGGCCAGGCCAAGGTACTTGGTGGCTCCTGTGCCAGACAGAAGAGGAATGGAGACAGGTCACCGAGAGTTTTCGCGAGAGGACCTCCCTTCGAGAACGGCAGCTCTACAAGCTCCTCAGTGAGGACTTCCTGCCTGAGATCTGCAACATGATCGCCCAGAAG hepatoblastoma 29414822 Expression Profiling Identifies Circular RNA Signature in Hepatoblastoma. Liu BH, Zhang BB, Liu XQ, Zheng S, Dong KR, Dong R. Cell Physiol Biochem. 2018 up microarray, qRT-PCR hepatoblastoma and adjacent normal liver samples hsa_circ_0063179 circRNA homo sapiens CSF2RB hsa_circ_0063179 TCCAGATGGCCCCTCCATCCCTCAACGTGACCAAGGATGGAGACAGCTACAGCCTGCGCTGGGAAACAATGAAAATGCGATACGAACACATAGACCACACATTTGAGATCCAGTACAGGAAAGACACGGCCACGTGGAAGGACAGCAAGACCGAGACCCTCCAGAACGCCCACAGCATGGCCCTGCCAGCCCTGGAGCCCTCCACCAGGTACTGGGCCAGGGTGAGGGTCAGGACCTCCCGCACCGGCTACAACGGGATCTGGAGCGAGTGGAGTGAGGCGCGCTCCTGGGACACCGAGTCGG Active Pulmonary Tuberculosis 29248507 Potential Diagnostic Power of Blood Circular RNA Expression in Active Pulmonary Tuberculosis. Qian Z, Liu H, Li M, Shi J, Li N, Zhang Y, Zhang X, Lv J, Xie X, Bai Y, Ge Q, Ko EA, Tang H, Wang T, Wang X, Wang Z, Zhou T, Gu W. EBioMedicine. 2018 Upregulated in TB patients compared to healthy controls. RNA-seq, microarray, qRT-PCR healthy controls and TB patients hsa_circ_0063561 circRNA homo sapiens ACO2 hsa_circ_0063561 ACTGAACCGGCCGCTGACACTCTCGGAGAAGATTGTGTATGGACACCTGGATGACCCCGCCAGCCAGGAAATTGAGCGAGGCAAGTCGTACCTGCGGCTGCGGCCGGACCGTGTGGCCATGCAGGATGCGACGGCCCAGATGGCCATGCTCCAGTTCATCAGCAGCGGGCTGTCCAAGGTGGCTGTGCCATCCACCATCCACTGTGACCATCTGATTGAAGCCCAGGTTGGGGGCGAGAAAGACCTGCGCCGGGCCAAGGACATCAACCAGGAAGTTTATAATTTCCTGGCAACTGCAGGTGCCAAATATGGCGTGGGCTTCTGGAAGCCTGGATCTGGAATCATTCACCAGATTATTCTGGAAAACTATGCGTACCCTGGTGTTCTTCTGATTGGCACTGACTCCCACACCCCCAATGGTGGCGGCCTTGGGGGCATCTGCATTGGAGTTGGGGGTGCCGATGCTGTGGATGTCATGGCTGGGATCCCCTGGGAGCTGAAGTGCCCCAAGGTGATTGGCGTGAAGCTGACGGGCTCTCTCTCCGGTTGGTCCTCACCCAAAGATGTGATCCTGAAGGTGGCAGGCATCCTCACGGTGAAAGGTGGCACAGGTGCAATCGTGGAATACCACGGGCCTGGTGTAGACTCCATCTCCTGCACTGGCATGGCGACAATCTGCAACATGGGTGCAGAAATTGGGGCCACCACTTCCGTGTTCCCTTACAACCACAGGATGAAGAAGTACCTGAGCAAGACCGGCCGGGAAGACATTGCCAATCTAGCTGATGAATTCAAGGATCACTTGGTGCCTGACCCTGGCTGCCATTATGACCAACTAATTGAAATTAACCTCAGTGAGCTGAAGCCACACATCAATGGGCCCTTCACCCCTGACCTGGCTCACCCTGTGGCAGAAGTGGGCAAGGTGGCAGAGAAGGAAGGATGGCCTCTGGACATCCGAGTGGGTCTAATTGGTAGCTGCACCAATTCAAGCTATGAAGATATGGGGCGCTCAGCAGCTGTGGCCAAGCAGGCACTGGCCCATGGCCTCAAGTGCAAGTCCCAGTTCACCATCACTCCAGGTTCCGAGCAGATCCGCGCCACCATTGAGCGGGACGGCTATGCACAGATCTTGAGGGATCTGGGTGGCATTGTCCTGGCCAATGCTTGTGGCCCCTGCATTGGCCAGTGGGACAGGAAGGACATCAAGAAGGGGGAGAAGAACACAATCGTCACCTCCTACAACAGGAACTTCACGGGCCGCAACGACGCAAACCCCGAGACCCATGCCTTTGTCACGTCCCCAGAGATTGTCACAGCCCTGGCCATTGCGGGAACCCTCAAGTTCAACCCAGAGACCGACTACCTGACGGGCACGGATGGCAAGAAGTTCAGGCTGGAGGCTCCGGATGCAGATGAGCTTCCCAAAGGG gastric cancer 28831102 Circular RNAs expression profiles in human gastric cancer. Dang Y, Ouyang X, Zhang F, Wang K, Lin Y, Sun B, Wang Y, Wang L, Huang Q. Sci Rep. 2017 downregulated in GC microarray, qRT-PCR GC tissues and the pair-matched normal tissues hsa_circ_0063591 circRNA homo sapiens XRCC6 hsa_circ_0063591 ATCTATGGGAGTCGTCAGATTATACTGGAGAAAGAGGAAACAGAAGAGCTAAAACGGTTTGATGATCCAGGTTTGATGCTCATGGGTTTCAAGCCGTTGGTACTGCTGAAGAAACACCATTACCTGAGGCCCTCCCTGTTCGTGTACCCAGAGGAGTCGCTGGTGATTG male infertile diseases 27958373 Identification and characterization of human testis derived circular RNAs and their existence in seminal plasma. Dong WW, Li HM, Qing XR, Huang DH, Li HG. Sci Rep. 2016 To validate these predicted circRNAs, 55 circRNAs of different abundance and lengths were randomly chosen for subsequent RT-PCR validation. Divergent primers were designed for circRNA detection. Among the 55 circRNAs, 30 of them could be specifically amplified. qRT-PCR human testis hsa_circ_006411 circRNA homo sapiens hsa_circ_006411 lung adenocarcinoma 29241190 CircRNA Expression Profile in Early-Stage Lung Adenocarcinoma Patients. Zhao J, Li L, Wang Q, Han H, Zhan Q, Xu M. Cell Physiol Biochem. 2017 down-regulated in lung cancer microarray, qRT-PCR tumors and paired adjacent normal tissue from non-smoking patients with lung adenocarcinoma, A549, H1299, BEAS-2B, B2B miR-516a-3p, miR-516b-3p circRNA-miRNA predicted hsa_circRNA_103307 circRNA homo sapiens SATB1 hsa_circ_0064557 GTGATCTTTAGACAGTGACTGAGTATGGATCATTTGAACGAGGCAACTCAGGGGAAAGAACATTCAGAAATGTCTAACAATGTGAGTGATCCGAAGGGTCCACCAGCCAAGATTGCCCGCCTGGAGCAGAACGGGAGCCCGCTAGGAAGAGGAAGGCTTGGGAGTACAGGTGCAAAAATGCAGGGAGTGCCTTTAAAACACTCGGGCCATCTGATGAAAACCAACCTTAGGAAAGGAACCATGCTGCCAGTTTTCTGTGTGGTGGAACATTATGAAAACGCCATTGAATATGATTGCAAGGAGGAGCATGCAGAATTTGTGCTGGTGAGAAAGGATATGCTTTTCAACCAGCTGATCGAAATGGCATTGCTGTCTCTAGGTTATTCACATAGCTCTGCTGCCCAGGCCAAAGGGCTAATCCAGGTTGGAAAGTGGAATCCAGTTCCACTGTCTTACGTGACAGATGCCCCTGATGCTACAGTAGCAGATATGCTTCAAGATGTGTATCATGTGGTCACATTGAAAATTCAGTTACACAGTTGCCCCAAACTAGAAGACTTGCCTCCCGAACAATGGTCGCACACCACAGTGAGGAATGCTCTGAAGGACTTACTGAAAGATATGAATCAGAGTTCATTGGCCAAGGAGTGCCCCCTTTCACAG papillary thyroid carcinoma 28288173 Microarray profiling of circular RNAs in human papillary thyroid carcinoma. Peng N, Shi L, Zhang Q, Hu Y, Wang N, Ye H. PLoS One. 2017 upregulated microarray, qRT-PCR PTC tumors, matching contralateral normal samples, benign thyroid lesions (i.e., follicular adenoma samples and multinodular goiter samples) hsa-miR-1264, hsa-miR-490-3p, hsa-miR-619-3p, hsa-miR-23a-3p, hsa-miR-23b-3p circRNA-miRNA predicted hsa_circ_0064735 circRNA homo sapiens UBP1 hsa_circ_0064735 TGATGTCTTGGCATTGCCCATTTTCAAGCAGGAAGATTCCAGCCTTCCATTGGATGGTGAAACAGAGCACCCACCCTTTCAGTATGTGATGTGTGCTGCAACGTCACCAGCAGTAAAACTGCATGATGAAACGCTTACTTATTTGAACCAAGGTCAGTCATATGAAATTCGGATGCTGGATAATCGGAAAATGGGTGATATGCCTGAGATCAATGGAAAATTAGTAAAGAGCATCATAAGGGTTGTATTCCATGACAGACGGCTACAATACACAGAGCATCAGCAACTTGAAGGATGGAAGTGGAATCGCCCAGGAGACAGACTTCTTGATTTAGATATTCCAATGTCTGTGGGAATAATTGACACAAGGACGAATCCAAGCCAGTTAAATGCGGTTGAATTTCTGTGGGACCCAGCAAAACGCACCTCTGCTTTCATTCAGGTACACTGCATCAGCACAGAATTTACTCCACGGAAGCACGGAGGTGAAAAGGGAGTGCCCTTTAGGATCCAGGTTGACACCTTTAAGCAGAATGAAAATGGAGAATACACAGATCATCTACACTCAGCTAGCTGCCAAATCAAAGTTTTTAAGCCTAAAGGTGCAGACAGGAAACAAAAAACTGACCGAGAGAAGATGGAGAAGAGAACAGCTCATGAAAAAGAAAAGTATCAGCCGTCCTATGATACCACAATCCTCACAGAGATGAGGCTTGAGCCTATAATTGAAGATGCAGTTGAACATGAGCAGAAAAAGTCCAGCAAGCGGACTTTGCCAGCAGACTACGGTGATTCTCTGGCAAAGCGAGGCAGTTGTTCTCCGTGGCCCGATGCCCCCACAGCCTATGTGAATAACAGCCCTTCCCCAGCGCCCACTTTCACCTCCCCACAGCAGAGCACTTGCAGTGTCCCAGACAGCAATTCTTCTTCCCCAAATCATCAGGGAGATGGAGCTTCACAGACCTCTGGTGAACAAATTCAGCCTTCAGCTACGATCCAGGAAACACAGCAATGGCTGCTCAAAAACAGATTCTCTTCCTACACAAGACTGTTCTCTAATTTTTCAG osteosarcoma 29229385 Circular RNA hsa_circ_0001564 regulates osteosarcoma proliferation and apoptosis by acting miRNA sponge. Song YZ, Li JF. Biochem Biophys Res Commun. 2018 upregulated microarray, qRT-PCR OS tissues and adjacent non-tumor tissues, NHOst, MG63, Saos-2, HOS, and U2OS hsa_circ_0066077 circRNA homo sapiens NT5DC2 hsa_circ_0066077 GGCCGAGGGCAGCGCGGGCGGCGGGCGGCGCGCGGTGGGCATGGCGGGTGCGGGGCTGCGGGCGGCCGCTCGGCGCTGGCTGCTGTGCGGAGGCCACGGCGGGCCGCGAGCCGCCTCGTCCTCGCCCTCCTGCCCTGGGTGCGGCCCCCCGGGTCCCGGCGCCCACTGCCCCGGCGTCCCGCGCTCCGCGCCCGCCCAGGCACCCACCAGCGGCGCCGACCTCAGCGCGCACCTATGGGCTCGCTACCAGGACATGCGGAGACTGGTGCACGACCTCCTGCCCCCCGAGGTCTGCAGTCTCCTGAACCCAGCAGCCATCTACGCCAACAACGAGATCAGCCTGCGTGACGTTGAGGTCTACGGCTTTGACTACGACTACACCCTGGCCCAGTATGCAGACGCACTGCACCCCGAGATCTTCAGTACCGCCCGTGACATCCTGATCGAGCACTACAAGTACCCAGAAGGGATTCGGAAGTATGACTACAACCCCAGCTTTGCCATCCGTGGCCTCCACTATGACATTCAGAAGAGCCTTCTGATGAAGATTGACGCCTTCCACTACGTGCAGCTGGGGACAGCCTACAGGGGCCTCCAGCCTGTGCCAGACGAGGAGGTGATTGAGCTGTATGGGGGTACCCAGCACATCCCACTATACCAGATGAGTGGCTTCTATGGCAAGGGTCCCTCCATTAAGCAGTTCATGGACATCTTCTCGCTACCGGAGATGGCTCTGCTGTCCTGTGTGGTGGACTACTTTCTGGGCCACAGCCTGGAGTTTGACCAAGCACATCTCTACAAGGACGTGACG hepatoblastoma 29414822 Expression Profiling Identifies Circular RNA Signature in Hepatoblastoma. Liu BH, Zhang BB, Liu XQ, Zheng S, Dong KR, Dong R. Cell Physiol Biochem. 2018 down microarray, qRT-PCR hepatoblastoma and adjacent normal liver samples hsa_circ_0066922 circRNA homo sapiens HGD hsa_circ_0066922 ATGCTTTTACAATTCAGATGGGGACTTCTTGATTGTTCCGCAGAAAGGGAACCTTCTCATTTACACCGAGTTTGGCAAGATGCTTGTACAGCCCAATGAGATCTGCGTCATTCAGAGAGGAATGCGGTTCAGCATAGATGTCTTTGAGGAGACCAGGGGCTACATCTTGGAGGTCTATGGTGTCCACTTTGAGTTACCTGACCTTGGACCAATTG Diabetes Retinopathy 29288268 Identification and Characterization of Circular RNAs as a New Class of Putative Biomarkers in Diabetes Retinopathy. Zhang SJ, Chen X, Li CP, Li XM, Liu C, Liu BH, Shan K, Jiang Q, Zhao C, Yan B. Invest Ophthalmol Vis Sci. 2017 Upregulated in diabetic human retinas compared to nodiabetic retinas. microarray, qRT-PCR diabetic human retinas, nodiabetic retinas hsa_circRNA_103454 circRNA homo sapiens ZNF148 hsa_circ_0067103 GCAGTTATACTTAAGCATGAACATTGACGACAAACTGGAAGGATTGTTTCTTAAATGTGGCGGCATAGACGAAATGCAGTCTTCCAGGACAATGGTTGTAATGGGTGGAGTGTCTGGCCAGTCTACTGTGTCTGGAGAGCTACAGGATTCAGTACTTCAAGATCGAAGTATGCCTCACCAGGAGATCCTTGCTGCAGATGAAGTGTTACAAGAAAGTGAAATGAGACAACAGGATATGATATCACATGATGAACTCATGGTCCATGAGGAGACAGTGAAAAATGATGAAGAGCAGATGGAAACACATGAAAGACTTCCTCAAGGACTACAGTATGCACTTAATGTCCCT papillary thyroid carcinoma 28288173 Microarray profiling of circular RNAs in human papillary thyroid carcinoma. Peng N, Shi L, Zhang Q, Hu Y, Wang N, Ye H. PLoS One. 2017 downregulated microarray, qRT-PCR PTC tumors, matching contralateral normal samples, benign thyroid lesions (i.e., follicular adenoma samples and multinodular goiter samples) has-miR-591, has-miR-7-5p, hsa-miR-660-5p, hsa-miR-144-5p, hsa-miR-452-3p circRNA-miRNA predicted hsa_circ_0067531 circRNA homo sapiens PIK3CB hsa_circ_0067531 AGTCGAGGTGGAAAAAAGTTTCTTCCTGTATTGAAAGAAATCTTGGACAGGGATCCCTTGTCTCAACTGTGTGAAAATGAAATGGATCTTATTTGGACTTTGCGACAAGACTGCCGAGAGATTTTCCCACAATCACTGCCAAAATTACTGCTGTCAATCAAGTGGAATAAACTTGAGGATGTTGCTCAGCTTCAGGCGCTGCTTCAGATTTGGCCTAAACTGCCCCCCCGGGAGGCCCTAGAGCTTCTGGATTTCAACTATCCAGACCAGTACGTTCGAGAATATGCTGTAGGCTGCCTGCGACAGATGAG hepatocellular carcinoma 29251325 CD90 promotes cell migration, viability and sphere-forming ability of hepatocellular carcinoma cells. Zhang K, Che S, Su Z, Zheng S, Zhang H, Yang S, Li W, Liu J. Int J Mol Med. 2018 Differentially expressed circRNAs between CD90+ and CD 90 cells microarray, qRT-PCR SK Hep 1 CD90+ and SK Hep 1 CD90 cells, HCC and non tumor tissues hsa_circ_0067745 circRNA homo sapiens ARHGEF26 hsa_circ_0067745 TTGGTTCGACTATGCAATGAGGGCGCCCGGAAGATGGAAAGGACTGAGATGATGTACACAATTAACTCCCAGCTGGAATTTAAAATTAAGCCTTTTCCTTTAGTCTCCTCTTCCCGGTGGTTGGTAAAAAGAGGTGAATTGACAGCCTATGTTGAAGACACTGTGCTTTTCTCAAGAAGGACATCCAAACAGCAAGTCTACTTCTTTCTCTTTAACGATGTGCTCATTATCACCAAGAAGAAGAGTGAAGAAAGTTACAACGTCAATGATTATTCCTTAAGAGATCAGCTATTGGTGGAATCTTGTGACAATGAAGAGCTTAATTCTTCTCCAGGGAAGAACAGCTCCACAATGCTCTATTCAAGACAGAGCTCTGCCAGTCACCTCTTTACTCTGACAGTCCTTAGTAACCACGCGAATGAGAAAGTGGAGATGCTACTAGGAGCTGAGACGCA hepatoblastoma 29414822 Expression Profiling Identifies Circular RNA Signature in Hepatoblastoma. Liu BH, Zhang BB, Liu XQ, Zheng S, Dong KR, Dong R. Cell Physiol Biochem. 2018 up microarray, qRT-PCR hepatoblastoma and adjacent normal liver samples circPRCKI circRNA homo sapiens PRKCI hsa_circ_0067934 TTATTTTGGAAAAACAAATTCGCATACCACGTTCTCTGTCTGTAAAAGCTGCAAGTGTTCTGAAGAGTTTTCTTAATAAGGACCCTAAGGAACGATTGGGTTGTCATCCTCAAACAGGATTTGCTGATATTCAGGGACACCCGTTCTTCCGAAATGTTGATTGGGATATG lung adenocarcinoma 29588350 The circular RNA circPRKCI promotes tumor growth in lung adenocarcinoma. Qiu M, Xia W, Chen R, Wang S, Xu Y, Ma Z, Xu W, Zhang E, Wang J, Fang T, Hu J, Dong G, Yin R, Wang J, Xu L. Cancer Res. 2018 circPRKCI is up-regulated in LAC tissues and positively correlated with tumor size and TNM stage. qRT-PCR lung adenocarcinoma tissues CircPRKCI promotes the proliferation and migration of LAC cell lines in vitro.CircPRKCI promotes cell proliferation via the circPRKCI-miR-545/589-E2F7 axis. loss of function, gain of function, mouse model A549, SPC-A1 female BALB/c nude mice miR-545, miR-589 circRNA-miRNA circPRKCI serves as a sponge for both miR-545 and miR-589 E2F7 hsa_circ_0067934 circRNA homo sapiens PRKCI hsa_circ_0067934 TTATTTTGGAAAAACAAATTCGCATACCACGTTCTCTGTCTGTAAAAGCTGCAAGTGTTCTGAAGAGTTTTCTTAATAAGGACCCTAAGGAACGATTGGGTTGTCATCCTCAAACAGGATTTGCTGATATTCAGGGACACCCGTTCTTCCGAAATGTTGATTGGGATATG Esophageal squamous cell carcinoma 27752108 Circular RNA has_circ_0067934 is upregulated in esophageal squamous cell carcinoma and promoted proliferation. Xia W, Qiu M, Chen R, Wang S, Leng X, Wang J, Xu Y, Hu J, Dong G, Xu PL, Yin R. Sci Rep. 2016 upregulated in esophageal squamous cellcarcinoma qRT-PCR, FISH primary ESCC tissues and adjacent normal tissues, HEEC, TE-1, KSYE410, TE-13, ECA-109 The high expression level of hsa_circ_0067934 was associated with poor differentiation (P = 0.025), I-II T stage (P = 0.04), and I-II TNM stage (P = 0.021). The in vitro silence of hsa_circ_0067934 by siRNA inhibited the proliferation and migration of ESCC cells and blocked cell cycle progression. loss of function ECA-109, TE-13 primary ESCC tissues and adjacent normal tissues hsa_circ_0068033 circRNA homo sapiens NAALADL2 hsa_circ_0068033 ATGAAAGTTTTAGACAAAGCCGATCAAACCTCACCTCTCTATTAGTGCAGCCCATCTCTGCACCCCTCGTTGCAAAACTGATCTCTTCGCCAAAAGCTAGAACCAAAAATGAAGCGTGTAGCTCTCTAGAGCTTCCAAATAATGAAATAAGAGTCGTCAGCATGCAAGTTCAGACAGTCACAAAATTGAAAACAGTTACTAATGTTGTTGGATTTGTAATGGGCTTGACATCTCCAGACCGGTATATCATAGTTGGCAGCCATCATCACACTGCACACAGTTATAATGGACAAGAATGGGCCAGTAGTACTGCAATAATCACAGCGTTTATCCGTGCCTTGATGTCAAAAGTTAAGAGAGGGTGGAGACCAGACCGAACTATTGTTTTCTGTTCTTGGGGAGGAACAGCTTTTGGCAATATTGGCTCATATGAATGGGGAGAGGATTTCAAGAAGGTTCTTCAGAAAAATGTTGTGGCTTATATTAGCCTCCACAGTCCCATAAGGGGGAACTCTAGTCTGTATCCTGTAGCATCACCATCTCTTCAGCAACTGGTAGTAGAGAAAAATAATTTCAACTGTACCAGAAGAGCCCAGTGCCCAGAAACCAATATCAGTTCTATACAGATACAAGGTGATGCTGATTATTTCATCAACCATCTTGGAGTTCCCATCGTGCAGTTTGCTTACGAGGACATCAAAACATTAGAGGGTCCAAGTTTTCTCTCCGAGGCCCGTTTTTCTACACGAGCAACAAAAATTGAAGAAATGGATCCCTCTTTCAACCTTCATGAAACCATTACTAAGCTCTCAGGAGAAGTGATTTTGCAAATTGCCAACGAACCTGTTCTGCCCTTTAATGCACTTGATATAGCTTTAGAAGTTCAAAACAACCTTAAAG breast cancer 29045858 Circulating circular RNA hsa_circ_0001785 acts as a diagnostic biomarker for breast cancer detection. Yin WB, Yan MG, Fang X, Guo JJ, Xiong W, Zhang RP. Clin Chim Acta. 2017 downregulated in breast cancer microarray, qRT-PCR breast cancer peripheral blood specimen hsa_circ_0068062 circRNA homo sapiens TBL1XR1 hsa_circ_0068062 CATCAACAACAGCAACTTGTGATTGGCGGTGACCGGATATTCAGTTGCACATCCCCACATCAATGCACTGCCAATGGGTTATATCCTGTGTTGTGACCTCATGGTTTAAGTGGGAATAAAGATGAGTATAAGCAGTGATGAGGTCAACTTCTTGGTATATAGATACTTGCAAGAGTCAG male infertile diseases 27958373 Identification and characterization of human testis derived circular RNAs and their existence in seminal plasma. Dong WW, Li HM, Qing XR, Huang DH, Li HG. Sci Rep. 2016 To validate these predicted circRNAs, 55 circRNAs of different abundance and lengths were randomly chosen for subsequent RT-PCR validation. Divergent primers were designed for circRNA detection. Among the 55 circRNAs, 30 of them could be specifically amplified. qRT-PCR human testis hsa_circ_0068087 circRNA homo sapiens GNB4 hsa_circ_0068087 ATTACATCAAATATGGACTCTGTGGGTCGAATACAAATGCGAACAAGACGTACACTGAGGGGCCACCTAGCTAAAATCTATGCTATGCATTGGGGATACGATTCCAGGCTGCTAGTCAGTGCTTCTCAAGATGGAAAATTAATTATTTGGGATAGCTATACAACAAATAAGATGCATGCTATTCCTTTGAGGTCCTCCTGGGTGATGACCTGTGCTTATGCTCCCTCTGGTAATTATGTTGCCTGTGGAGGCTTGGACAACATCTGCTCTATATATAACTTAAAGACCAGAGAGGGAAATGTGAGAGTAAGCCGAGAGTTGCCAGGTCACACAGGGTACTTGTCCTGCTGTCGTTTTTTAGATGACAGCCAAATTGTTACAAGTTCAGGAGATACAACTTGTGCTTTATGGGACATCGAAACTGCCCAGCAGACCACCACATTCACTGGGCATTCTGGAGATGTGATGAGTCTTTCTTTGAGTCCTGACATGAGGACTTTTGTTTCTGGTGCTTGTGATGCCTCTTCCAAATTATGGGATATTCGAGATGGAATGTGTAGACAGTCTTTCACGGGACATGTCTCAGATATCAATGCTGTCAGTTTTTTCCCAAATGGATATGCCTTCGCCACTGGCTCTGATGATGCCACTTGCCGGCTCTTTGACCTTCGTGCAGATCAAGAGTTATTATTGTATTCTCATGACAATATCATCTGTGGAATCACTTCTGTAGCCTTCTCAAAAAGTGGGCGTCTCTTGTTGGCTGGTTACGATGACTTTAATTGTAATGTATGGGACACGCTAAAAGGAGATCGTGCAGGTGTCCTTGCTGGTCATGACAACCGTGTGAGCTGCTTAGGTGTAACTGATGATGGCATGGCTGTGGCAACAGGCTCTTGGGACAGTTTTCTTAGAATCTGGAATTAACAGTGTCATACATATTTGTTCTCCATTGATATATCTGGAGAAATCAATGCTACAGCCTATAGCTGTGAAAAAATTCTACCTTATATTTGCAGGTGAAGATTTTTCTATTAGATTATCTACAAAAACAAGCTTTCAGTAAACTACCAAAAAAAAAGTGGGGGTGGAGGAAAAAAGGCAAAGGCGCCTTCTGAGATCAAAAGGACCAGTGTATTAATTTGAGGGGTTGGGTTATTTTAACCTTGGTGAATTGTTGTGTGTACTCAGAGTGTATTTTCTTTGTGTAGAACAGAATGTACACATTATAGCAGCTCGCCATTGTGTTTGCATTTTTTAAGAAGTACATTTTTAACTTTGTATACACAAGAAATGTCATATTTTTGAGTTTTGTAATGGAAGAACCAGGCACAGAAACAGACAGAAATGATACTGTATGTGTGTGTATTTATGTCTGAAGAAAGTCCCCTTGAATTCTGATATCTCTTTGAATCTAAGAGATCCTGATAGCTTCATGTTTAAGAGCATTGACAGGTGGGGCACCTCTGAGGGGAGTTCATTGTTTCTCATGCATCATTTGCCATATACTATTAATCAAAGTGCTTGCTTTCAGTCCTTTGAGGGGACAGATAATCTGAAGGCCAGAGATTAGAGATTTCACTGATATTTTGGACATACATAAGAAACATCATTATAATTAATAAAAAGTAGGTAATAGCATATAAATGGTTCTTGACATTTTAAAAGCCTGGTTATGATCAGTTGACACTTTGAGTACCCCCCTAAATAGCTGGACTTTCCTTTTCATTTCATATTTGGAACTAAGTTTGTAGCGTATACTCATCTTTCAGAAGTTTGGTAAACATTGGGATTGTCCCTGCATCTGAACATCTTTCCCAGTGCTATCAGTATACATCTAGAGAGGAAATGCAATGTGACAGTGTTACATTTGGAGAGAAGTGTGAAATCTAACCAATCGCTAGCACATATTTGTTGTAATACGGTGGTTTATTTCATGTTTGCATACTATAAAATCTGAATTGATGTGAAATATCTGTGCCTTTAAATTTCTTAAACCTTTAAGCTTTTTGTTCTGTTTTGCAACATTTTGTAGTATTTCTTCCCTTCCTTAGCACAAAATACTGGTTTCTAAGTGGTTTTGCTTCAAAGGATGTCTAGATGTAAGTGATTCCACTTAAAGCCAAAATAAAAATTCCTAAAGCAGTTCTTAAAGGAGTTAGAGAGCTATATTAAACAGTTTTTCTGTGGTATAATAATGTGTCTCTTACTAGAAGTCCCCCACGACCAAGTTAAAGATACTTTTCCTGTTGGATTCTCTTTTACAAATAAGTCTAAATGACTGATAATAGAAGATTGTTAGTCTTGCTTGATGGTAAAGTCTTGGATTATTCTGATATATAGACGTGCATTGTTTTGTAACTTAGTTACTTTTCAGATAGGTCTGTGTTAACTTTTGAACATGTGTAACTTAACCTAAATACTCCCAAACTTTACCTCTAAATTTTTGTTTTTATGTTGTGAATGTGCTAATATGTGCATCAACTGTAAAGATGTATCAGTTTTATTAAAATCAGTTGACAATTAGAATAATAAAGTGGATAAAGGCAAATTAAGATATAGGACCAAAACAGAATATTGTAGATGGCAGTTATGAATGTATATTTATATTTTGATTAAGATTTCTATTAACTTTTTGGCTGGGCAGAGTGGCTTACACCTATAATCCCAGCAATTTGGGAGGCCAAGGTGGGCAGATCACTTGAGGTCAGGAGTTCGCGACCAGCCTACCCAACATGGTGAAACCCCATCTCTTCTAAAAATACAAACATTAGCCGGGCGTGGTGGCACATTCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGATTCGCCTGAACCCGGGAGGCAGAGGTTGCAGTGAGCCGAGATTGTGCCACTGCACTCCAGCCTAGGCGACAGAGTGAGACTCCATCTCAAATTGGAAAAAAAAAAAATTATATGAACTTTTGCTATTAATGTTTATTTGTAGGCTATTTATATCACTTCATAAAGAACAGTTCTTTGAGAAAAGAATAAAGGAATGTATTCATTTCCAGAAAAAGAGGGTTGGGGAAAGTTTGCCATGTAGGTTAGTCAGAAGAAAGCAATTCTATTATGCATAAAAATAACCTTAAATATGTAAGAGAGTATCTCCTCTACTTAAAAGTTATTATAGTAGTCACAGGCATACAGACCACAGGAATTCTATGGTCTTAACATATTTTAAAATTACATTTATTTTAATGTTCTTAAAGTTTATGAAGAGGAGTTTAAAGCAATTCCCATAATTAAATATTTACTCGGCAACTAAAAACTATTTAACACTTGTGGTTAATTATACACATAAACAAATGGCGACAGAGTAGCCTCACTACCACAATTACTTCATGGTTACACCTTTGCTTTCTAATAATAGGGGCTCCAGTTGCTAAATATATTTGTTTACTTACAGTTTAAGTTGAGCTGATTGTTGAATTCTGTTATTGTTCCTGAATTCAATGAGTATATAATTTGTAGAGATGTTGAATAGTTTGGATCTTAGTTTTTAAGGCTGAAAAATCTGGCTGGATTTAGTTTTTAAAAATTTGCATCATCAAGAATATTGCAGTTAATGTTCCTTTTTTTTTTTTTTTAAAGACAGAGTCTCACTCTGTCACCCAGGCTGGAGTGTACAGTGGTGTGATTTTGGCTCATTGCAACCTCAACCTCTGCCTCCTGGGTTCAAGCAATTCTTGTGCCTCAGCCTCCCAAGTAGCTGGGACTATAGGCATGTGCCACCATGCCCGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACCATCTTGGCCAGTCTGATCTCGTACTCCTGGCCTCAAGTGATCCACCAGCCTCAGCCTCCCAAAGTGCTGGGATTACAGACGTGAGCCACCGTGCCCAGCCAGGTTTCCTTCTTTACCTTCTAAGAAACATTTAAACATAATGTGCCTGAGAAGGTTAATTTGTTGACTCTGTAGCATGTCAAGAAGAGTAGTTTTTTGAGATCTGGCAAGAATATTTTAGAGATACATATTCTTTTCTAAGTATGTTATCACCCTGTGGTGTTGAGCATATCGTCCCAAAAACCTGCTTCAGCAAGCAGTTCTTGGCCAGGCATGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCACGAGGTCAGGAGTTCAAGACCAGCCTGGCCAAGATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCGGGCGTGGAGGTGGGCGCCTGTCAGCTACTCGTGAGGCTGAGGCAGAGAATTACTTGAACTCAGGAGGTGGAGGTTTTGGTGAGCTGAGATGGCGCCACTGCACTCCAACCCGAGCGACAGAGCAAGATTCCGTCCCAAAAAGAAAAAGCAGTTTTTGCCATCAGCAAGGATATCTCCTCCACTTTAATGGACAGGCCTCATTTTTGGCAGCTATGCTGTTTGAGATGTAGACTGAATATCCAAGGTTCCTCCCTAGCTCAAGTTTTTACTTGTGATTACACACACCACATTGAATTCCGTCTTCAGAGGCAAAGATTTGGGCTTCATATCTCAACAGCAAAAGGGCCTGTTCAGCAATTCCCTTCATTTTAGACTCATATGACCTCAGCGATTGCATGATAGTAGTAAACTAGTCTCCTGGAAATAATGGATGTAGGTGCTTCTAGAATATGTTACAGAATTTCAGACTTAACCTATTAATAGATAAATGGATCTTGACTTAAGGTGACAAAATGAAACTTTTATTATTGCTTAAAAATGCTGTGCCAATATTGTATAACTAGCTCCTCTAATACTTTTGGTATTTTGGATTTAATAATAAGACCTTAAGCATTTTAAATGTGAACATGTTCAGGGAAGTATGCTTTGATGTAAATGTCTCAGATCTAAGTTGTAACACAATTGAATACTTGTGGCTTATTCTTGGTTTAACTTAGGAAAACTGGTTAAACAATCCCCCATTTGGGCCTGTCATCATTTTAATAGTGACGATGTTCTTTCTGAAATCTTCAGGGTCGGAGTCAGGCTGAATTTTTTTAAAAATTAAATATTATGTTCAAATTCTTTCCTTTTTGCCATTGTGAAAAAGCAAAATTTTAAATGATTTCTCCTGTTAGAATTTTTAAAAATACCCACAGGTTGGACCATCTTTCTTATGGGTTGCACAATGAATTTATATTTTAAATTAGATTAAGTAGAATGTGAAGTACATTTCAGATTTACTAGTTTTCTTTCCATTGTTCATTTTGGGTTGCCTCAGATTCAGTGTATATTTTAAAATATTGGTTACATAATAGGTACTCAATGAAATGGTTTATAGTAGAATATCTAAGCTAGCACTTTATTTTAAAAAGTAACTTATTAATTAATCACACATTGATGGTACACCTTGTATTTAGCAAATGTTTGCATGTTGATAAAATCTCCTATGTCTTCTTTCTTAAATCCAGTTGCTGATTTTGTAAAATACAGTTGTGATAAAGCAGCATTACGGGGGGGAAAAAGCTATATTCCAACTGGTGTTAAATGTATTCAACAAAATCTTACATCATACAGTATTTATTTCTTAATTAATAGAACTTCAGTGATATACTTGGTAGATATCTCAAGCCTTTTGTCTTTTACACAATGGTGCTCTATCCTATTGTTTTCTTTTCAAAGAAGCATCTGAACACTTGCATTTCTATTTTCCTATCCAAAGGCATCCACATCTAAGTGTGTTTTTAAAGTTGATTAAAATTATTTTTCTGTTAAAGCATTCTGAAAGTGTTTGTCTTTACCTAGAATGATTTGTACACACTCGTGGTCAACTGAACATGAATGTCAGTAGTAGTCTAATTATGGGAAGGGTAAACGTGTTAGATTAAGGCTCTTAAAGCTCTAAACCATATAAACTATGGACTTGTATCATGATTTAACTGTTCTTAGATCTTTCTTACACAGTGATTCATTCCTCTATTTGTACAGTGGCTTTATGAAATGTTGTGAATTGATACTGTAATCAATAAAGTGCTTTTAACCAGA type 2 diabetes mellitus 27878383 Hsa_circ_0054633 in peripheral blood can be used as a diagnostic biomarker of pre-diabetes and type 2 diabetes mellitus. Zhao Z, Li X, Jian D, Hao P, Rao L, Li M. Acta Diabetol. 2017 significantly different among the three groups and increased gradually from the control group to the pre-diabetes group to the T2DM group. qRT-PCR, microarray peripheral blood of T2DM, pre-diabetes and control groups hsa_circ_0068489 circRNA homo sapiens MASP1 hsa_circ_0068489 GTGGCTGCTTCTCTATTATGCTCTGTGCTTCTCCCTGTCAAAGGCTTCAGCCCACACCGTGGAGCTAAACAATATGTTTGGCCAGATCCAGTCGCCTGGTTATCCAGACTCCTATCCCAGTGATTCAGAGGTGACTTGGAATATCACTGTCCCAGATGGGTTTCGGATCAAGCTTTACTTCATGCACTTCAACTTGGAATCCTCCTACCTTTGTGAATATGACTATGTGAAGGTAGAAACTGAGGACCAGGTGCTGGCAACCTTCTGTGGCAGGGAGACCACAGACACAGAGCAGACTCCCGGCCAGGAGGTGGTCCTCTCCCCTGGCTCCTTCATGTCCATCACTTTCCGGTCAGATTTCTCCAATGAGGAGCGTTTCACAGGCTTTGATGCCCACTACATGGCTGTGGATGTGGACGAGTGCAAGGAGAGGGAGGACGAGGAGCTGTCCTGTGACCACTACTGCCACAACTACATTGGCGGCTACTACTGCTCCTGCCGCTTCGGCTACATCCTCCACACAGACAACAGGACCTGCCGAGTGGAGTGCAGTGACAACCTCTTCACTCAAAGGACTGGGGTGATCACCAGCCCTGACTTCCCAAACCCTTACCCCAAGAGCTCTGAATGCCTGTATACCATCGAGCTGGAGGAGGGTTTCATGGTCAACCTGCAGTTTGAGGACATATTTGACATTGAGGACCATCCTGAGGTGCCCTGCCCCTATGACTACATCAAGATCAAAGTTGGTCCAAAAGTTTTGGGGCCTTTCTGTGGAGAGAAAGCCCCAGAACCCATCAGCACCCAGAGCCACAGTGTCCTGATCCTGTTCCATAGTGACAACTCGGGAGAGAACCGGGGCTGGAGGCTCTCATACAGGGCTGCAGGAAATGAGTGCCCAGAGCTACAGCCTCCTGTCCATGGGAAAATCGAGCCCTCCCAAGCCAAGTATTTCTTCAAAGACCAAGTGCTCGTCAGCTGTGACACAGGCTACAAAGTGCTGAAGGATAATGTGGAGATGGACACATTCCAGATTGAGTGTCTGAAGGATGGGACGTGGAGTAACAAGATTCCCACCTGTAAAATTGTAGACTGTAGAGCCCCAGGAGAGCTGGAACACGGGCTGATCACCTTCTCTACAAGGAACAACCTCACCACATACAAGTCTGAGATCAAATACTCCTGTCAGGAGCCCTATTACAAGATGCTCAACAATAACACAGGTATATATACCTGTTCTGCCCAAGGAGTCTGGATGAATAAAGTATTGGGGAGAAGCCTACCCACCTGCCTTCCAGAGTGTGGTCAGCCCTCCCGCTCCCTGCCAAGCCTGGTCAAGAGGATCATTGGGGGCCGAAATGCTGAGCCTGGCCTCTTCCCGTGGCAGGCCCTGATAGTGGTGGAGGACACTTCGAGAGTGCCAAATGACAAGTGGTTTGGGAGTGGGGCCCTGCTCTCTGCGTCCTGGATCCTCACAGCAGCTCATGTGCTGCGCTCCCAGCGTAGAGACACCACGGTGATACCAGTCTCCAAGGAGCATGTCACCGTCTACCTGGGCTTGCATGATGTGCGAGACAAATCGGGGGCAGTCAACAGCTCAGCTGCCCGAGTGGTGCTCCACCCAGACTTCAACATCCAAAACTACAACCACGATATAGCTCTGGTGCAGCTGCAGGAGCCTGTGCCCCTGGGACCCCACGTTATGCCTGTCTGCCTGCCAAGGCTTGAGCCTGAAGGCCCGGCCCCCCACATGCTGGGCCTGGTGGCCGGCTGGGGCATCTCCAATCCCAATGTGACAGTGGATGAGATCATCAGCAGTGGCACACGGACCTTGTCAGATGTCCTGCAGTATGTCAAGTTACCCGTGGTGCCTCACGCTGAGTGCAAAACTAGCTATGAGTCCCGCTCGGGCAATTACAGCGTCACGGAGAACATGTTCTGTGCTGGCTACTACGAGGGCGGCAAAGACACGTGCCTTGGAGATAGCGGTGGGGCCTTTGTCATCTTTGATGACTTGAGCCAGCGCTGGGTGGTGCAAGGCCTGGTGTCCTGGGGGGGACCTGAAGAATGCGGCAGCAAGCAGGTCTATGGAGTCTACACAAAGGTCTCCAATTACGTGGACTGGGTGTGGGAGCAGATGGGCTTACCACAAAGTGTTGTGGAGCCCCAGGTGGAACGGTGAGCTGACTTACTTCCTCGGGGCCTGCCTCCCCTGAGCGAAGCTACACCGCACTTCCGACAGCACACTCCACATTACTTATCAGACCATATGGAATGGAACACACTGACCTAGCGGTGGCTTCTCCTACCGAGACAGCCCCCAGGACCCTGAGAGGCAGAGTGTGGTATAGGGAAAAGGCTCCAGGCAGGAGACCTGTGTTCCTGAGCTTGTCCAAGTCTCTTTCCCTGTCTGGGCCTCACTCTACCGAGTAATACAATGCAGGAGCTCAACCAAGGCCTCTGTGCCAATCCCAGCACTCCTTTCCAGGCCATGCTTCTTACCCCAGTGGCCTTTATTCACTCCTGACCACTTATCAAACCCATCGGTCCTACTGTTGGTATAACTGAGCTTGGACCTGACTATTAGAAAATGGTTTCTAACATTGAACTGAATGCCGCATCTGTATATTTTCCTGCTCTGCCTTCTGGGACTAGCCTTGGCCTAATCCTTCCTCTAGGAGAAGAGCATTCAGGTTTTGGGAGATGGCTCATAGCCAAGCCCCTCTCTCTTAGTGTGATCCCTTGGAGCACCTTCATGCCTGGGGTTTCTCTCCCAAAAGCTTCTTGCAGTCTAAGCCTTATCCCTTATGTTCCCCATTAAAGGAATTTCAAAAGACATGGAGAAAGTTGGGAAGGTTTGTGCTGACTGCTGGGAGCAGAATAGCCGTGGGAGGCCCACCAAGCCCTTAAATTCCCATTGTCAACTCAGAACACATTTGGGCCCATATGCCACCCTGGAACACCAGCTGACACCATGGGCGTCCACACCTGCTGCTCCAGACAAGCACAAAGCAATCTTTCAGCCTTGAAATGTATTATCTGAAAGGCTACCTGAAGCCCAGGCCCGAATATGGGGACTTAGTCGATTACCTGGAAAAAGAAAAGACCCACACTGTGTCCTGCTGTGCTTTTGGGCAGGAAAATGGAAGAAAGAGTGGGGTGGGCACATTAGAAGTCACCCAAATCCTGCCAGGCTGCCTGGCATCCCTGGGGCATGAGCTGGGCGGAGAATCCACCCCGCAGGATGTTCAGAGGGACCCACTCCTTCATTTTTCAGAGTCAAAGGAATCAGAGGCTCACCCATGGCAGGCAGTGAAAAGAGCCAGGAGTCCTGGGTTCTAGTCCCTGCTCTGCCCCCAACTGGCTGTATAACCTTTGAAAAATCATTTTCTTTGTCTGAGTCTCTGGTTCTCCGTCAGCAACAGGCTGGCATAAGGTCCCCTGCAGGTTCCTTCTAGCTGGAGCACTCAGAGCTTCCCTGACTGCTAGCAGCCTCTCTGGCCCTCACAGGGCTGATTGTTCTCCTTCTCCCTGGAGCTCTCTCTCCTGAAAATCTCCATCAGAGCAAGGCAGCCAGAGAAGCCCCTGAGAGGGAATGATTGGGAAGTGTCCACTTTCTCAACCGGCTCATCAAACACACTCCTTTGTCTATGAATGGCACATGTAAATGATGTTATATTTTGTATCTTTTATATCATATGCTTCACCATTCTGTAAAGGGCCTCTGCATTGTTGCTCCCATCAGGGGTCTCAAGTGGAAATAAACCCTCGTGGATAACCAACA Diabetes Retinopathy 29288268 Identification and Characterization of Circular RNAs as a New Class of Putative Biomarkers in Diabetes Retinopathy. Zhang SJ, Chen X, Li CP, Li XM, Liu C, Liu BH, Shan K, Jiang Q, Zhao C, Yan B. Invest Ophthalmol Vis Sci. 2017 Downregulated in diabetic human retinas compared to nodiabetic retinas. microarray, qRT-PCR diabetic human retinas, nodiabetic retinas hsa_circ_0069131 circRNA homo sapiens AFAP1 hsa_circ_0069131 CAATGGAAGAGTTAATAGTTGAACTTCGTCTCTTTCTTGAACTCCTGGACCATGAATATCTAACCTCAACTGTCAGGGAGAAAAAGGCAGTGATAACCAACATTCTGCTAAGAATACAGTCATCCAAAGGTTTTGATGTGAAGGACCATGCTCAGAAGCAGGAGACCGCTAACAGCCTGCCAGCCCCTCCTCAGATGCCCCTGCCGGAGATCCCTCAGCCCTGGCTGCCTCCTGACAGTGGGCCTCCACCATTGCCAACATCCTCCCTCCCAGAAGGTTATTATGAGGAAGCTGTGCCGCTGAGCCCCGGAAAAGCTCCGGAATACATCACATCAAATTATGATTCCGATGCGATGAGCAGCTCTTATGAGTCGTATGATGAAGAGGAGGAGGATGGGAAGGGGAAGAAAACCCGGCACCAGTGGCCCTCCGAGGAGGCCTCCATGGACCTGGTCAAGGACGCCAAAATCTGCGCCTTCCTGCTGCGGAAGAAGCGGTTCGGCCAGTGGACCAAGTTGCTCTGCGTCATCAAAGACACCAAACTGCTGTGCTATAAAAGTTCCAAGGACCAGCAGCCTCAGATGGAACTGCCACTCCAAGGCTGTAACATTACGTACATCCCGAAAGACAGCAAAAAGAAGAAGCACGAGCTGAAGATTACTCAGCAGGGCACGGACCCGCTTGTTCTCGCCGTCCAGAGCAAGGAACAGGCCGAGCAGTGGCTGAAGGTGATCAAAGAAGCCTACAGTGGTTGTAGTGGCCCCGTGGATTCAGAGTGTCCTCCTCCACCAAGCTCCCCGGTGCACAAGGCAGAACTGGAGAAGAAACTGTCTTCAGAGAGACCCAGCTCAGATGGGGAGGGTGTTGTGGAAAATGGAATTACCACATGTAATGGAAAGGAGCAAGTGAAGAGGAAGAAAAGTTCCAAATCAGAGGCCAAGGGCACTGTGTCGAAAGTCACTGGGAAAAAAATCACCAAGATCATCAGTCTGGGAAAGAAAAAGCCGTCCACAGACGAGCAGACCTCCTCAGCTGAGGAAGATGTTCCCACCTGCGGCTATCTGAACGTGCTCTCCAACAGCCGCTGGCGAGAGCGCTGGTGCCGAGTGAAAGATAACAAGCTCATTTTCCACAAGGACAGGACCGACCTGAAGACCCATATTGTGTCTATTCCGCTCCGTGGCTGCGAGGTGATCCCGGGTTTGGATTCTAAACATCCTCTGACGTTCCGGCTGCTGCGCAACGGCCAGGAGGTTGCAGTATTGGAGGCATCTTCTTCTGAAGACATGGGCAGGTGGATTGGGATTTTACTCGCAGAGACGGGATCGTCCACAGACCCGGAGGCTCTGCACTATGACTACATTGATGTGGAGATGTCTGCAAGTGTCATTCAGACAGCCAAACAGACCTTCTGTTTCATGAACAGGCGTGTTATATCTGCTAACCCATATCTAGGGGGCACCTCCAACGGCTATGCCCACCCCAGCGGGACGGCACTTCATTATGACGATGTCCCGTGCATCAACGGCTCGTGGGAACCGGAAGACGGCTTTCCTGCTTCCTGCAGCAGAGGCTTGGGAGAAGAGGTGCTTTATGATAACGCAGGCCTGTACGATAACTTGCCGCCTCCGCACATCTTTGCCCGCTACTCTCCTGCTGACAGAAAGGCCTCTAGGCTGTCTGCTGACAAGCTGTCCTCTAACCATTACAAATACCCTGCCTCCGCTCAGTCTGTCACTAATACCTCTTCTGTGGGGAGGGCGTCTCTCGGGCTCAACTCGCAG gastric cancer 28639908 Circular RNAs play an important role in late-stage gastric cancer: Circular RNA expression profiles and bioinformatics analyses. Fang Y, Ma M, Wang J, Liu X, Wang Y. Tumour Biol. 2017 downregulated in GC microarray, qRT-PCR III stage gastric cancer and paired paracarcinoma tissue hsa_circ_0070391 circRNA homo sapiens KLHL8 hsa_circ_0070391 GTTGGCTCAAAGCTAATCTCTTGTCACAAGCTGGTATTGGCTTGTGTTATTCCCTACTTTAGAGCCATGTTTCTTTCTGAAATGGCTGAAGCCAAGCAAACGCTGATTGAGATTAGAGATTTTGATGGTGATGCAATAGAAGACTTGGTAAAGTTTGTCTATTCTTCACGGCTCACTTTGACTGTTGACAATGTCCAGCCTCTCTTATATGCAGCCTGTATTCTGCAGGTTGAACTGGTGGCTAGAGCTTGTTGTGAATACATGAAGTTACATTTTCATCCCTCCAATTGCCTGGCAGTAAGAGCCTTTGCAGAAAGTCACAATCGAATAGACTTAATGGACATGGCGGATCAGTATGCCTGTGACCATTTTACTGAAGTAGTGGAGTGTGAAGACTTTGTAAGTGTATCACCGCAGCACCTCCATAAGCTTTTGTCCTCCAGTGATCTAAATATTGAAAATGAAAAGCAGGTCTATAATGCTGCCATCAAGTGGCTTCTTGCCAATCCTCAGCATCATTCCAAATGGTTGGATGAAACACTTGCACAGGTTCGCCTGCCATTGTTGCCGGTTGATTTTCTTATGGGTGTTGTGGCAAAAGAACAGATTGTCAAGCAAAATCTAAAATGTAGAGATTTACTGGATGAAGCAAGAAATTACCACCTTCACTTGAGTAGCAGAGCAGTACCTGACTTTGAATACTCCATTCGGACTACCCCAAGGAAGCATACTGCTGGTGTGCTGTTTTGTGTAGGTGGTCGAGGTGGATCTGGTGACCCCTTTCGCAGTATTGAATGCTATTCTATCAACAAAAACAGTTGGTTCTTTGGACCAGAAATGAATAGTCGAAGGCGACATGTGGGTGTAATCTCTGTGGAAG hepatocellular carcinoma 29144509 Circular RNA expression is suppressed by androgen receptor (AR)-regulated adenosine deaminase that acts on RNA (ADAR1) in human hepatocellular carcinoma. Shi L, Yan P, Liang Y, Sun Y, Shen J, Zhou S, Lin H, Liang X, Cai X. Cell Death Dis. 2017 upregulated more than fivefold as revealed by circRNA microarray after AR knocking down in MHCC-104h cells microarray, qRT-PCR MHCC-97h, LM3 and LO10 cells hsa_circ_0070963 circRNA homo sapiens SCLT1 hsa_circ_0070963 CTTTTTAGCTCCTCTTGTTACTGAGTATGATAAACACCTAGGAGAACTAAATGGGCAGCTGAAATATTACCAGAAACAGGTGGGTGAGATGAAATTACAACTTGAAAATGTCATCAAGGAAAATGAAAGGTTGCACAGTGAATTAAAAGATGCTGTTGAAAAAAAATTGGAGGCCTTTCCCCTGGGCACAGAGGTAGGAACTGACATATATGCAGATGATGAAACAGTCAGAAACCTTCAAGAACAATTGCAGCTAGCCAATCAAGAAAAAACTCAGGCTGTGGAACTCTGGCAGACTGTTTCTCAGGAGTTGGACAGACTACACAAGCTTTACCAGGAACATATGACTGAGGCCCAGATTCATGTATTTGAAAGTCAAAAACAAAAGGATCAGCTATTTGATTTTCAACAACTGACCAAACAACTTCATGTTACTAATGAGAACATGGAAGTG Radiation-induced liver fibrosis 28774651 Microarray profiling of circular RNAs and the potential regulatory role of hsa_circ_0071410 in the activated human hepatic stellate cell induced by irradiation. Chen Y, Yuan B, Wu Z, Dong Y, Zhang L, Zeng Z. Gene. 2017 significantly down-regulated in irradiated HSC compared with normal HSC. qRT-PCR, microarray irradiated hepatic stellate cell (HSC) and normal HSC hsa_circ_0071410 circRNA homo sapiens PALLD hsa_circ_0071410 AGGATTTCCAAAGAAGGCCAGTAGAACTGCTAGAATAGCCTCCGATGAGGAAATTCAAGGCACAAAGGATGCTGTTATTCAAGACCTGGAACGAAAACTTCGCTTCAAGGAGGACCTCCTGAACAATGGCCAGCCGAGGTTAACATACGAAGAAAGAATGGCTCGTCGACTGCTAGGTGCTGACAGTGCAACTGTCTTTAATATTCAGGAGCCAGAAGAGGAAACAGCTAATCAGGACATTGGTTCTCCTCATGCTTCTGTAGGGAGTCCTCTGGATGGTCAAAAGGAATACAAAGTCTCCAGCTGTGAACAGAGACTCATCAGTGAAATAGAGTACAGGCTAGAAAGGTCTCCTGTGGATGAATCAGGTGATGAAGTTCAGTATGGAGATGTGCCTGTGGAAAATGGAATGGCACCATTCTTTGAGATGAAGCTGAAACATTACAAGATCTTTGAGGGAATGCCAGTAACTTTCACATGTAGAGTGGCTGGAAATCCAAAGCCAAAGATCTATTGGTTTAAAGATGGGAAGCAGATCTCTCCAAAGAGTGATCACTACACCATTCAAAGAGATCTCGATGGGACCTGCTCCCTCCATACCACAGCCTCCACCCTAGATGATGATGGGAATTATACAATTATGGCTGCAAACCCTCAGGGCCGCATCAGTTGTACTGGACGGCTAATGGTACAGGCTGTCAACCAAAGAGGTCGAAGTCCCCGGTCTCCCTCAGGCCATCCTCATGTCAGAAGGCCTCGTTCTAGATCAAGGGACAGTGGAGACGAAAATGAACCAATTCAGGAGCGATTCTTCAGACCTCACTTCTTGCAGGCTCCTGGAGATCTGACTGTTCAAGAAGGAAAACTCTGCAGAATGGACTGCAAA Radiation-induced liver fibrosis 28774651 Microarray profiling of circular RNAs and the potential regulatory role of hsa_circ_0071410 in the activated human hepatic stellate cell induced by irradiation. Chen Y, Yuan B, Wu Z, Dong Y, Zhang L, Zeng Z. Gene. 2017 significantly up-regulated in irradiated HSC compared with normal HSC. qRT-PCR, microarray irradiated hepatic stellate cell (HSC) and normal HSC inhibition of hsa_circ_0071410 increased the expression of miR-9-5p,resulting in the attenuation of irradiation induced HSC activation. loss of function Human hepatic stellate cell line LX2 hsa_circ_0072359 circRNA homo sapiens OXCT1 hsa_circ_0072359 GGCACACTTGCAGAGAGGATCCGTGCAGGCGGGGCTGGAGTTCCTGCATTTTACACCCCAACAGGGTATGGGACCCTGGTACAAGAAGGAGGATCGCCCATCAAATACAACAAAGATGGCAGTGTTGCCATTGCCAGTAAGCCAAGAGAGGTGAGGGAGTTCAATGGTCAGCACTTTATTTTGGAGGAAGCAATTACAGGGGATTTTGCTTTGGTGAAAGCCTGGAAGGCGGACCGAGCAGGAAACGTGATTTTCAGGAAAAGTGCAAGGAATTTCAACTTGCCAATGTGCAAAGCTGCAGAAACCACAGTGGTAGAGGTTGAAGAAATTGTGGATATTGGAGCATTTGCTCCAGAAGACATCCATATTCCTCAGATTTATGTACATCGCCTTATAAAGGGAGAAAAATATGAGAAAAGAATTGAGCGTTTATCAATCCGGAAAGAGGGAGATGGGGAAGCCAAATCTGCTAAACCTGGAGATGACGTAAGGGAACGAATCATCAAGAGGGCCGCTCTTGAGTTTGAGGATGGCATGTATGCTAATTTGGGCATAGGAATCCCTCTCCTGGCCAGCAATTTTATCAGCCCAAATATAACTGTTCATCTTCAAAGTGAAAATGGAGTTCTGGGTTTGGGTCCATATCCACGACAACATGAAGCTGATGCAGATCTCATCAATGCAGGCAAGGAAACAGTTACTATTCTTCCAGGAGCCTCTTTTTTCTCCAGCGATGAATCATTTGCAATGATTAGAGGTGGACACGTCGATCTGACAATGCTAGGAGCGATGCAGGTTTCCAAATATGGTGACCTGGCTAACTGGATGATACCTGGGAAGATGGTGAAAGGAATGGGAGGTGCTATGGATTTAGTGTCCAGTGCGAAAACCAAAGTGGTGGTCACCATGGAGCATTCTGCAAAGGGAAATGCACATAAAATCATGGAGAAATGTACATTACCATTGACTGGAAAGCAATGTGTCAACCGCATTATTACTGAAAAG hepatoblastoma 29414822 Expression Profiling Identifies Circular RNA Signature in Hepatoblastoma. Liu BH, Zhang BB, Liu XQ, Zheng S, Dong KR, Dong R. Cell Physiol Biochem. 2018 down microarray, qRT-PCR hepatoblastoma and adjacent normal liver samples hsa_circ_0072410 circRNA homo sapiens NNT hsa_circ_0072410 ATTCTGATAGTTGGTGGTGGTGTTGCTGGGCTTGCTTCTGCAGGCGCAGCAAAGTCGATGGGTGCAATTGTTCGAGGATTTGACACAAGAGCTGCAGCTTTGGAACAGTTCAAGTCTCTTGGTGCTGAGCCCTTGGAGGTGGACTTGAAGGAATCTGGTGAGGGACAAGGAGGATATGCAAAAGAGATGTCCAAAGAGTTCATTGAAGCTGAAATGAAACTCTTTGCTCAACAATGCAAGGAGGTAGACATCCTTATCAGCACAGCACTTATTCCAGGTAAAAAAGCTCCAGTTTTATTTAATAAAGAAATGATTGAGTCAATGAAGGAAGGTTCAGTTGTTGTGGATTTAGCTGCTGAGGCTGGTGGAAACTTTGAAACCACTAAGCCAGGAGAACTCTACATTCATAAGGGAATTACTCACATAGGCTACACAGACCTGCCCAGCCGAATGGCCACTCAGGCCAGCACCCTATATTCCAACAACATCACCAAACTCCTGAAGGCCATCAGCCCGGACAAAGATAATTTTTATTTTGATGTGAAAGATGACTTTGACTTTGGTACGATGGGTCATGTCATTAGAGGAACTGTAGTGATGAAAGATGGTAAAGTGATTTTCCCAGCTCCCACACCGAAAAATATTCCTCAAGGTGCCCCAGTAAAACAGAAGACAGTGGCTGAGCTGGAAGCTGAAAAAGCAGCTACCATTACACCCTTCAGGAAGACAATGTCAACGGCTTCTGCATATACAGCAGGTCTCACAGGGATACTGGGTTTGGGCATTGCGGCTCCCAATCTAGCCTTTTCTCAGATGGTGACCACTTTTGGCTTGGCTGGCATTGTGGGGTATCATACCGTCTGGGGAGTGACCCCTGCTCTCCACTCACCACTGATGTCTGTGACAAATGCAATCTCAGGGCTGACTGCAGTTGGTGGGTTGGCACTGATGGGAGGACATTTGTATCCTTCCACAACTTCTCAGGGCCTTGCTGCTCTTGCTGCATTCATATCCTCTGTCAACATTGCAGGTGGCTTTCTGGTGACTCAGAGAATGCTGGACATGTTCAAGCGTCCCACTGACCCCCCAGAATACAACTACCTGTACCTGCTCCCTGCCGGCACCTTTGTTGGTGGATATTTAGCTGCCCTCTACAGTGGTTATAACATTGAACAGATCATGTACCTAGGCTCGGGTTTGTGCTGTGTCGGTGCCTTGGCTGGCCTCTCCACCCAGGGAACAGCACGTCTTGGCAATGCACTGGGCATGATTGGGGTTGCTGGAGGACTGGCAGCCACCCTCGGAGTCCTAAAACCGGGCCCAGAATTACTAGCTCAGATGTCTGGAGCGATGGCTTTGGGTGGTACCATTGGATTGACAATTGCCAAACGCATCCAGATTTCTGATTTACCTCAATTAGTTGCTGCTTTTCACAGTTTAGTGGGTTTGGCAGCTGTACTTACTTGCATAGCTGAGTACATTATAGAATATCCACATTTTGCTACGGATGCAGCAGCAAATCTCACCAAGATTGTGGCCTACCTCGGCACTTACATTGGTGGCGTCACCTTTAGTGGGTCTCTCATTGCCTATGGAAAATTGCAGGGTCTCCTGAAATCTGCCCCTCTCCTACTGCCTGGAAGGCACTTACTCAATGCAGGCTTACTGGCTGCTAGTGTGGGCGGGATAATCCCATTCATGGTGGACCCAAGCTTTACTACTGGCATCACCTGTCTGGGTTCAGTGTCTGCTCTCTCTGCTGTCATGGGTGTGACTTTGACAGCTGCTATTGGGGGTGCTGACATGCCCGTCGTTATCACTGTGCTGAACAGCTACTCAGGCTGGGCCCTGTGTGCAGAGGGCTTCCTGCTCAACAACAATCTGCTGACCATCGTGGGTGCACTCATAGGCTCGTCTGGTGCTATCCTGTCATACATCATGTGTGTGGCAATGAATCGCTCCCTGGCTAATGTGATTCTTGGAGGCTATGGCACCACTTCAACAGCTGGTGGAAAACCCATGGAAATTTCTGGCACACATACGGAAATCAACCTTGACAATGCAATTGACATGATTCGAGAAGCTAATAGCATTATTATTACACCAGGCTATGGTCTCTGTGCAGCCAAAGCTCAATACCCCATTGCTGATTTGGTAAAGATGCTCACTGAGCAAGGCAAAAAAGTCAG Diabetes Retinopathy 29288268 Identification and Characterization of Circular RNAs as a New Class of Putative Biomarkers in Diabetes Retinopathy. Zhang SJ, Chen X, Li CP, Li XM, Liu C, Liu BH, Shan K, Jiang Q, Zhao C, Yan B. Invest Ophthalmol Vis Sci. 2017 Downregulated in diabetic human retinas compared to nodiabetic retinas. microarray, qRT-PCR diabetic human retinas, nodiabetic retinas hsa_circ_0072765 circRNA homo sapiens CCNB1 hsa_circ_0072765 GTTGATGTCGAGCAACATACTTTGGCCAAATACCTGATGGAACTAACTATGTTGGACTATGACATGGTGCACTTTCCTCCTTCTCAAATTGCAGCAGGAGCTTTTTGCTTAGCACTGAAAATTCTGGATAATGGTGAATGG Radiation-induced liver fibrosis 28774651 Microarray profiling of circular RNAs and the potential regulatory role of hsa_circ_0071410 in the activated human hepatic stellate cell induced by irradiation. Chen Y, Yuan B, Wu Z, Dong Y, Zhang L, Zeng Z. Gene. 2017 significantly up-regulated in irradiated HSC compared with normal HSC. qRT-PCR, microarray irradiated hepatic stellate cell (HSC) and normal HSC hsa_circ_0074362 circRNA homo sapiens ARHGAP26 hsa_circ_0074362 GAAGCCAAAAAGAAGTATGACAAAGAGACAGAAAAGTATTGTGGCATCTTAGAAAAACACTTGAATTTGTCTTCCAAAAAGAAAGAATCTCAGCTTCAGGAGGCAGACAGCCAAGTGGACCTGGTCCGGCAGCATTTCTATGAAGTATCCCTGGAATATGTCTTCAAGGTGCAGGAAGTCCAAGAGAGAAAGATGTTTGAGTTTGTGGAGCCTCTGCTGGCCTTCCTGCAAGGACTCTTCACTTTCTATCACCATGGTTACGAACTGGCCAAGGATTTCGGGGACTTCAAGACACAGTTAACCATTAGCATACAGAACACAAGAAATCGCTTTGAAGGCACTAGATCAGAAGTGGAATCACTGATGAAAAAGATGAAGGAGAATCCCCTTGAGCACAAGACCATCAGTCCCTACACCATGGAGGGATACCTCTACGTGCAGGAGAAACGTCACTTTGGAACTTCTTGGGTGAAGCACTACTGTACATATCAACGGGATTCCAAACAAATCACCATGGTACCATTTGACCAAAAGTCAGGAGGAAAAGGGGGAGAAGATGAATCAGTTATCCTCAAATCCTGCACACGGCGGAAAACAGACTCCATTGAGAAGAGGTTTTGCTTTGATGTGGAAGCAGTAGACAGGCCAGGGGTTATCACCATGCAAGCTTTGTCGGAAGAGGACCGGAGGCTCTGGATGGAAGCCATGGATGGCCGGGAACCT gastric cancer 29240459 Downregulated expression of hsa_circ_0074362 in gastric cancer and its potential diagnostic values. Xie Y, Shao Y, Sun W, Ye G, Zhang X, Xiao B, Guo J. Biomark Med. 2018 hsa circ 0074362 was significantly downregulated in gastric cancer qRT-PCR gastric cancer tissues with the paired normal adjacent tissues, GES-1, AGS, BGC-823, HGC-27, MGC-803, SGC-7901 The expression levels of hsa_circ_0074362 were associated with CA19¨C9 and lymphatic metastasis. The area under receiver operating characteristic curve of hsa circ 0074362 was 0.630. gastric cancer tissues hsa_circ_0074930 circRNA homo sapiens SLIT3 hsa_circ_0074930 TACCCTCAACAACAACAACATCAGTCGCATCCTGGTCACCAGCTTCAACCACATGCCGAAGATCCGAACTCTGCGCCTCCACTCCAACCACCTGTACTGCGACTGCCACCTGGCCTGGCTCTCGGATTGGCTGCGACAGCGACGGACAGTTGGCCAGTTCACACTCTGCATGGCTCCTGTGCATTTGAGGGGCTTCAACGTGGCGGATGTGCAGAAGAAGGAGTACGTGTGCCCAGCCCCCCACTCGGAGCCCCCATCCTGCAATGCCAACTCCATCTCCTGCCCTTCGCCCTGCACGTGCAGCAATAACATCGTGGACTGTCGAGGAAAGGGCTTGATGGAGATTCCTGCCAACTTGCCGGAGGGCATCGTCGAAAT Colorectal cancer 28656150 Microarray Analysis of Circular RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells. Xiong W, Ai YQ, Li YF, Ye Q, Chen ZT, Qin JY, Liu QY, Wang H, Ju YH, Li WH, Li YF. Biomed Res Int. 2017 up microarray, qRT-PCR CRR (chemoradiation resistance)-HCT116 and the parental HCT116 cells hsa_circ_0075001 circRNA homo sapiens NPM1 hsa_circ_0075001 GTTGTGAACTAAAGGCCGACAAAGATTATCACTTTAAGGTGGATAATGATGAAAATGAGCACCAGTTATCTTTAAGAACGGTCAGTTTAGGGGCTGGTGCAAAGGATGAGTTGCACATTGTTGAAGCAGAGGCAATGAATTACGAAGGCAGTCCAATTAAAGTAACACTGGCAACTTTGAAAATGTCTGTACAGCCAACGGTTTCCCTTGGGGGCTTTGAAATAACACCACCAGTGGTCTTAAGGTTGAAGTGTGGTTCAGGGCCAGTGCATATTAGTGGACAGCACTTAGTAGCTGTGGAGGAAGATGCAGAGTCAGAAGATGAAGAGGAGGAGGATGTGAAACTCTTAAGTATATCTGGAAAGCGGTCTGCCCCTGGAGGTGGTAGCAAGGTTCCACAGAAAAAAGTAAAACTTGCTGCTGATGAAGATGATGACGATGATGATGAAGAGGATGATGATGAAGATGATGATGATGATGATTTTGATGATGAGGAAGCTGAAGAAAAAGCGCCAGTGAAGAAA acute myeloid leukemia 28971903 Circular RNAs of the nucleophosmin (NPM1) gene in acute myeloid leukemia. Hirsch S, Blätte TJ, Grasedieck S, Cocciardi S, Rouhi A, Jongen-Lavrencic M, Paschka P, Krönke J, Gaidzik VI, Döhner H, Schlenk RF, Kuchenbauer F, Döhner K, Dolnik A, Bullinger L. Haematologica. 2017 Circular NPM1 transcripts in leukemic and healthy cells RT-PCR,sanger sequencing Acute myeloid leukemia patients and healthy controls High versus low hsa_circ_0075001 expression defines patient subgroups characterized by distinct gene expression patterns, such as lower expression of components of the Toll-like receptor signaling pathway in high hsa_circ_0075001 expression cases. Acute myeloid leukemia patients and healthy controls hsa_circ_0075829 circRNA homo sapiens LINC00340 hsa_circ_0075829 GATCTGCATTTACTGCTCAACCACATCTAATTTGATGTCCTCTGCAGATTTAAAATGTGTGCCTTCTTTTCCGTCACCAAGTCATCCCTGGGTTACTACTGAACATCCTTCTCAATTCCCCCCGACCCATGGATGGCTGTTCTCCATTGTCTGTTTCACCAGATGTCCTCAAAACAAACAGACAGAAGAAGGAAGTGGCTAATGGAGCTGTGGAGTCCAAGTGTGACTGCCAAGAGGAATCCAGCAAAGCCAAAAAGCCCAAGCATGTAGCCCTGCCCGAAGCACGCCACACGCATGGAAAACCCAGAGGAAATGAGTGAGGATCAATGGGAAGAAGAGAGCCAGCCAG basal cell carcinoma 27097056 Circular RNA expression in basal cell carcinoma. Sand M, Bechara FG, Sand D, Gambichler T, Hahn SA, Bromba M, Stockfleth E, Hessam S. Epigenomics. 2016 up microarray, qRT-PCR, FISH nodular BCC and nonlesional skin tissues hsa_circ_0075960 circRNA homo sapiens None hsa_circ_0075960 GGTGTGGGCCGAAGATATGCTCATGTGGTGTTGAGGAAAGCAGACATTGACCTCACCAAGAGGGCGGGAGAACTCACTGAGGATGAGGTGAGGACAAGGAAGGGGGCTGGGGGTGGGGTCAGCCTCAGAAAGGGGTCCATCTAGATCTGACCTTGGTCTGCCTGCCAGGTGGAACGTGTGATCACCATTATGCAGAATCCACGCCAGTACAAGATCCCAGACTGGTTCTTGAACAGACAGAAGGATGTAAAGGATGGAAAATACAGCCAGGTGTGTACTGAAATGAGGGCAGGATTAGAGGAAGGGTGGAGGGTCCTAACAGAATTGGGCATAGGAGGTCAGGGGATAAAACATCCCTTGCCCCCTCCTCTGAATCCAGGTCCTAGCCAATGGTCTGGACAACAAGCTCCGTGAAGACCTGGAGCGACTGAAGAAGATTCGGGCCCATAGAGGGCTGCGTCACTTCTGGGGGTGAGTGGGGGGTCTCATCTCCCTGCCTACCTCGACTCAGCATTCCTCCTACTCGCTCTTCTTTTTCCCCAACCTTTTGTTTCTGCTGTGCATGACCTGTGACTCTTCTCTTTTTACCTGCAGCCTTCGTGTCCGAGGCCAGCACACCAAGACCACTGGCCGCCGTGGCCGCACCGTGGGTGTGTCCAAGAAGAAATAAGTCTGTAGGCCTTGTCTGTTAATAAATAGTTTATATAC endometrial cancer 29334253 Circular RNA expression in extracellular vesicles isolated from serum of patients with endometrial cancer. Xu H, Gong Z, Shen Y, Fang Y, Zhong S. Epigenomics. 2018 up RNA-seq, northern blots, qRT-PCR extracellular vesicles isolated from serum of patients with endometrial cancer hsa_circ_0076995 circRNA homo sapiens EEF1A1 hsa_circ_0076995 ATGCCTTGGTTCAAGGGATGGAAAGTCACCCGTAAGGATGGCAATGCCAGTGGAACCACGCTGCTTGAGGCTCTGGACTGCATCCTACCACCAACTCGTCCAACTGACAAGCCCTTGCGCCTGCCTCTCCAGGATGTCTACAAAATTGGTG hepatocellular carcinoma 29144509 Circular RNA expression is suppressed by androgen receptor (AR)-regulated adenosine deaminase that acts on RNA (ADAR1) in human hepatocellular carcinoma. Shi L, Yan P, Liang Y, Sun Y, Shen J, Zhou S, Lin H, Liang X, Cai X. Cell Death Dis. 2017 upregulated more than fivefold as revealed by circRNA microarray after AR knocking down in MHCC-103h cells microarray, qRT-PCR MHCC-97h, LM3 and LO9 cells hsa_circ_0078710 circRNA homo sapiens THBS2 hsa_circ_0078710 GAGGAGGAGACGGCATCCAGTACAGAGGGGCTGGACTTGGACCCCTGCAGCAGCCCTGCACAGGAGAAGCGGCATATAAAGCCGCGCTGCCCGGGAGCCGCTCGGCCACGTCCACCGGAGCATCCTGCACTGCAGGGCCGGTCTCTCGCTCCAGCAGAGCCTGCGCCTTTCTGACTCGGTCCGGAACACTGAAACCAGTCATCACTGCATCTTTTTGGCAAACCAGGAGCTCAGCTGCAGGAGGCAGGATGGTCTGGAGGCTGGTCCTGCTGGCTCTGTGGGTGTGGCCCAGCACGCAAGCTGGTCACCAGGACAAAGACACGACCTTCGACCTTTTCAGTATCAGCAACATCAACCGCAAGACCATTGGCGCCAAGCAGTTCCGCGGGCCCGACCCCGGCGTGCCGGCTTACCGCTTCGTGCGCTTTGACTACATCCCACCGGTGAACGCAGATGACCTCAGCAAGATCACCAAGATCATGCGGCAGAAGGAGGGCTTCTTCCTCACGGCCCAGCTCAAGCAGGACGGCAAGTCCAGGGGCACGCTGTTGGCTCTGGAGGGCCCCGGTCTCTCCCAGAGGCAGTTCGAGATCGTCTCCAACGGCCCCGCGGACACGCTGGATCTCACCTACTGGATTGACGGCACCCGGCATGTGGTCTCCCTGGAGGACGTCGGCCTGGCTGACTCGCAGTGGAAGAACGTCACCGTGCAGGTGGCTGGCGAGACCTACAGCTTGCACGTGGGCTGCGACCTCATAGACAGCTTCGCTCTGGACGAGCCCTTCTACGAGCACCTGCAGGCGGAAAAGAGCCGGATGTACGTGGCCAAAGGCTCTGCCAGAGAGAGTCACTTCAGGGGTTTGCTTCAGAACGTCCACCTAGTGTTTGAAAACTCTGTGGAAGATATTCTAAGCAAGAAGGGTTGCCAGCAAGGCCAGGGAGCTGAGATCAACGCCATCAGTGAGAACACAGAGACGCTGCGCCTGGGTCCGCATGTCACCACCGAGTACGTGGGCCCCAGCTCGGAGAGGAGGCCCGAGGTGTGCGAACGCTCGTGCGAGGAGCTGGGAAACATGGTCCAGGAGCTCTCGGGGCTCCACGTCCTCGTGAACCAGCTCAGCGAGAACCTCAAGAGAGTGTCGAATGATAACCAGTTTCTCTGGGAGCTCATTGGTGGCCCTCCTAAGACAAGGAACATGTCAGCTTGCTGGCAGGATGGCCGGTTCTTTGCGGAAAATGAAACGTGGGTGGTGGACAGCTGCACCACGTGTACCTGCAAGAAATTTAAAACCATTTGCCACCAAATCACCTGCCCGCCTGCAACCTGCGCCAGTCCATCCTTTGTGGAAGGCGAATGCTGCCCTTCCTGCCTCCACTCGGTGGACGGTGAGGAGGGCTGGTCTCCGTGGGCAGAGTGGACCCAGTGCTCCGTGACGTGTGGCTCTGGGACCCAGCAGAGAGGCCGGTCCTGTGACGTCACCAGCAACACCTGCTTGGGGCCCTCCATCCAGACACGGGCTTGCAGTCTGAGCAAGTGTGACACCCGCATCCGGCAGGACGGCGGCTGGAGCCACTGGTCACCTTGGTCTTCATGCTCTGTGACCTGTGGAGTTGGCAATATCACACGCATCCGTCTCTGCAACTCCCCAGTGCCCCAGATGGGGGGCAAGAATTGCAAAGGGAGTGGCCGGGAGACCAAAGCCTGCCAGGGCGCCCCATGCCCAATCGATGGCCGCTGGAGCCCCTGGTCCCCGTGGTCGGCCTGCACTGTCACCTGTGCCGGTGGGATCCGGGAGCGCACCCGGGTCTGCAACAGCCCTGAGCCTCAGTACGGAGGGAAGGCCTGCGTGGGGGATGTGCAGGAGCGTCAGATGTGCAACAAGAGGAGCTGCCCCGTGGATGGCTGTTTATCCAACCCCTGCTTCCCGGGAGCCCAGTGCAGCAGCTTCCCCGATGGGTCCTGGTCATGCGGCTCCTGCCCTGTGGGCTTCTTGGGCAATGGCACCCACTGTGAGGACCTGGACGAGTGTGCCCTGGTCCCCGACATCTGCTTCTCCACCAGCAAGGTGCCTCGCTGTGTCAACACTCAGCCTGGCTTCCACTGCCTGCCCTGCCCGCCCCGATACAGAGGGAACCAGCCCGTCGGGGTCGGCCTGGAAGCAGCCAAGACGGAAAAGCAAGTGTGTGAGCCCGAAAACCCATGCAAGGACAAGACACACAACTGCCACAAGCACGCGGAGTGCATCTACCTGGGCCACTTCAGCGACCCCATGTACAAGTGCGAGTGCCAGACAGGCTACGCGGGCGACGGGCTCATCTGCGGGGAGGACTCGGACCTGGACGGCTGGCCCAACCTCAATCTGGTCTGCGCCACCAACGCCACCTACCACTGCATCAAGGATAACTGCCCCCATCTGCCAAATTCTGGGCAGGAAGACTTTGACAAGGACGGGATTGGCGATGCCTGTGATGATGACGATGACAATGACGGTGTGACCGATGAGAAGGACAACTGCCAGCTCCTCTTCAATCCCCGCCAGGCTGACTATGACAAGGATGAGGTTGGGGACCGCTGTGACAACTGCCCTTACGTGCACAACCCTGCCCAGATCGACACAGACAACAATGGAGAGGGTGACGCCTGCTCCGTGGACATTGATGGGGACGATGTCTTCAATGAACGAGACAATTGTCCCTACGTCTACAACACTGACCAGAGGGACACGGATGGTGACGGTGTGGGGGATCACTGTGACAACTGCCCCCTGGTGCACAACCCTGACCAGACCGACGTGGACAATGACCTTGTTGGGGACCAGTGTGACAACAACGAGGACATAGATGACGACGGCCACCAGAACAACCAGGACAACTGCCCCTACATCTCCAACGCCAACCAGGCTGACCATGACAGAGACGGCCAGGGCGACGCCTGTGACCCTGATGATGACAACGATGGCGTCCCCGATGACAGGGACAACTGCCGGCTTGTGTTCAACCCAGACCAGGAGGACTTGGACG hepatoblastoma 29414822 Expression Profiling Identifies Circular RNA Signature in Hepatoblastoma. Liu BH, Zhang BB, Liu XQ, Zheng S, Dong KR, Dong R. Cell Physiol Biochem. 2018 up microarray, qRT-PCR hepatoblastoma and adjacent normal liver samples hsa_circ_0078849 circRNA homo sapiens None hsa_circ_0078849 GGTGTGGGCCGAAGATATGCTCATGTGGTGTTGAGGAAAGCAGACATTGACCTCACCAAGAGGGCGGGAGAACTCACTGAGGATGAGGTGAGGACAAGGAAGGGGGCTGGGGGTGGGGTCAGCCTCAGAAAGGGGTCCATCTAGATCTGACCTTGGTCTGCCTGCCAGGTGGAACGTGTGATCACCATTATGCAGAATCCACGCCAGTACAAGATCCCAGACTGGTTCTTGAACAGACAGAAGGATGTAAAGGATGGAAAATACAGCCAGGTGTGTACTGAAATGAGGGCAGGATTAGAGGAAGGGTGGAGGGTCCTAACAGAATTGGGCATAGGAGGTCAGGGGATAAAACATCCCTTGCCCCCTCCTCTGAATCCAGGTCCTAGCCAATGGTCTGGACAACAAGCTCCGTGAAGACCTGGAGCGACTGAAGAAGATTCGGGCCCATAGAGGGCTGCGTCACTTCTGGGGGTGAGTGGGGGGTCTCATCTCCCTGCCTACCTCGACTCAGCATTCCTCCTACTCGCTCTTCTTTTTCCCCAACCTTTTGTTTCTGCTGTGCATGACCTGTGACTCTTCTCTTTTTACCTGCAGCCTTCGTGTCCGAGGCCAGCACACCAAGACCACTGGCCGCCGTGGCCGCACCGTGGGTGTGTCCAAGAAGAAATAAGTCTGTAGGCCTTGTCTGTTAATAAATAGTTTATATAC endometrial cancer 29334253 Circular RNA expression in extracellular vesicles isolated from serum of patients with endometrial cancer. Xu H, Gong Z, Shen Y, Fang Y, Zhong S. Epigenomics. 2018 up RNA-seq, northern blots extracellular vesicles isolated from serum of patients with endometrial cancer hsa_circ_0078955 circRNA homo sapiens None hsa_circ_0078955 GGTGTGGGCCGAAGATATGCTCATGTGGTGTTGAGGAAAGCAGACATTGACCTCACCAAGAGGGCGGGAGAACTCACTGAGGATGAGGTGAGGACAAGGAAGGGGGCTGGGGGTGGGGTCAGCCTCAGAAAGGGGTCCATCTAGATCTGACCTTGGTCTGCCTGCCAGGTGGAACGTGTGATCACCATTATGCAGAATCCACGCCAGTACAAGATCCCAGACTGGTTCTTGAACAGACAGAAGGATGTAAAGGATGGAAAATACAGCCAGGTGTGTACTGAAATGAGGGCAGGATTAGAGGAAGGGTGGAGGGTCCTAACAGAATTGGGCATAGGAGGTCAGGGGATAAAACATCCCTTGCCCCCTCCTCTGAATCCAGGTCCTAGCCAATGGTCTGGACAACAAGCTCCGTGAAGACCTGGAGCGACTGAAGAAGATTCGGGCCCATAGAGGGCTGCGTCACTTCTGGGGGTGAGTGGGGGGTCTCATCTCCCTGCCTACCTCGACTCAGCATTCCTCCTACTCGCTCTTCTTTTTCCCCAACCTTTTGTTTCTGCTGTGCATGACCTGTGACTCTTCTCTTTTTACCTGCAGCCTTCGTGTCCGAGGCCAGCACACCAAGACCACTGGCCGCCGTGGCCGCACCGTGGGTGTGTCCAAGAAGAAATAAGTCTGTAGGCCTTGTCTGTTAATAAATAGTTTATATAC endometrial cancer 29334253 Circular RNA expression in extracellular vesicles isolated from serum of patients with endometrial cancer. Xu H, Gong Z, Shen Y, Fang Y, Zhong S. Epigenomics. 2018 up RNA-seq, northern blots extracellular vesicles isolated from serum of patients with endometrial cancer hsa_circ_0079549 circRNA homo sapiens RAPGEF5 hsa_circ_0079549 ACTCTATCAAGAAGAATATCTAATCCGTACCTTGAACATACGCCTTCCCAGATTTATGGAGAGAATTCTTCTTGTGCAGGAAGAGCATTGAGGAATATTATTATCGTTCAAGCAGCTGACCTGATAAAGGACAGAGTGAACCTCAAGGGGTTTTACAGGAGGAGCTGCGTTGGGTCAGAGCTGGTAGACTGGCTTCTAGAACACTGTCCTTTCGTCCAGTGCAGATCTATGGCCATAGGAGTCTGGCAACTCCTACTGGACATGGGAATTATGTTATCAGTGGACCAGCATCTATACTTTCAAGATACTTATGTTTTCTACCAGTTTTCCTCTGATGAATGTAGCTACTTGTACTGTGAATTTGAAAGAGAAGAAGAATGGCAAAATGGTGTCAAGCTTTTACTGCAACTTGTGCCTCTCATTCCTGCCAGAGGTGGCATCTGTGAACTGTCTCATCAGAAAATTGAAGACTCCGAAGAAAGCAGTGATGAAATTCTTGTGCGTCTAACATCTGCGGTGCAGAGAGAGCTAGCAGCTGTTATTGCTTTGAAAGCAAGGAAGTCTGCAATTGAACAAGATGAAGAAAACAACGACAAACATGTAGCTGTAACAGAAGCCGAAAGTGTTCCAGATTCTCAGGCAGGGGTGATGTGCAAGCTCCAGGAAAGAGATGAAATCGGACGAATTGAACTAGTCCAGAAGCTGGCAAAAGAAAACTATCAGTTTTTGCAGACGGACAAAAAAGAACAGGAGAAGTCTGAACACCAAGATGATGAAGTGACGACTGTTCAGGTTAAAGAGCAAGACCAGAGCGTCCTGGTGCTGAAGAAAGTGCAGTGCTGTGGCCCAGCCCCCACAGCTGGGAGTGCGGAGAGCCATTGGAGATATGTGGTGGTGTCCGGGACCCCGGAGAAGATTTTGGAGCACCTTTTGAATGACTTGCACCTGGAAGAAGTCCAGGACAAAGAAACAGAGACCCTCCTGGATGACTTCCTTCTCACGTACACTGTCTTCATGACAACTGATGACTTGTGCCAGGCTCTGTTAAGGCACTATTCTGCTAAGAAGTATCAAGGCAAAGAGGAAAACTCAGACGTTCCGCGTAGGAAACGTAAAGTCTTGCATCTTGTTTCCCAGTGGATTGCTCTGTACAAAGACTGGTTACCTGAAGATGAACATTCAAAAATGTTTTTAAAGACCATATATAGGAATGTACTGGATGATGTTTATGAATATCCAATACTTGAAAAAGAATTGAAAGAATTTCAAAAGATACTTGGAATGCACCGTCGTCACACTGTAGATGAATATTCACCACAAAAAAAGAATAAAGCCCTTTTCCACCAATTCAGTCTTAAGGAGAACTGGCTCCAGCATAGAGGAACTGTGACTGAAACGGAGGAAATTTTCTGCCACGTGTATATAACAGAGCACTCCTATGTCAGTGTGAAGGCAAAAGTTTCCAGTATAGCCCAAGAGATCCTAAAAGTCGTGGCAGAAAAGATCCAGTATGCAGAAGAGGATCTGGCTCTGGTGGCCATCACATTCTCTGGGGAAAAGCATGAACTTCAGCCAAATGACTTAGTCATCTCCAAATCCCTCGAGGCATCTGGTCGAATATATGTCTACCGGAAAGACCTGGCGGACACTTTGAACCCATTTGCAGAAAATGAGGAATCACAGCAAAGGTCGATGAGGATTTTGGGAATGAACACTTGGGATCTTGCTCTGGAATTAATGAATTTTGATTGGAGTCTATTCAATTCAATTCACGAGCAAGAGCTGATCTACTTCACGTTCAGCAGACAGGGAAGTGGGGAACACACTGCAAATCTCAGCCTTCTGCTCCAGAGATGCAATGAGGTCCAGCTTTGGGTGGCCACGGAGATTCTGCTCTGCAGCCAGCTGGGCAAGCGAGTGCAGCTGGTGAAAAAATTCATCAAAATTGCGGCTCACTGCAAAGCCCAGAGAAACCTGAATTCTTTCTTTGCCATTGTGATGGGTCTCAACACTGCTTCTGTCAGTCGACTGTCGCAGACCTGGGAGAAAATCCCTGGGAAGTTTAAGAAACTTTTCTCTGAACTTGAAAGTTTAACAGATCCTTCCCTAAATCACAAAGCCTACAGAGATGCATTCAAAAAGATGAAGCCACCAAAAATCCCTTTCATGCCCTTATTGCTTAAAGATGTAACATTTATTCATGAAGGAAATAAAACTTTTTTGGATAATCTTGTCAATTTTGAAAAGCTG hepatoblastoma 29414822 Expression Profiling Identifies Circular RNA Signature in Hepatoblastoma. Liu BH, Zhang BB, Liu XQ, Zheng S, Dong KR, Dong R. Cell Physiol Biochem. 2018 up microarray, qRT-PCR hepatoblastoma and adjacent normal liver samples circ-GRB10 circRNA homo sapiens GRB10 hsa_circ_0080210 ATATTCTGGAGGAAGGTGTGAACGCAACTTTGCCTCCCAGGGAACAAACATCCTCCTTCTAAGTGGTAGATGTGGGTGAGCTGACCCTGCTGGAGTCTGTCCCCTGGGCTACCCTCTGCTTCCCCCCATTGTGAGTGGTCCGTGAAGCACAGCGTTGACCAGACCTAAACCTGTTTGCTCCCAGGACAAGGTGGAGCAGACACCTCGCAGTCAACAAGACCCGGCAGGACCAGGACTCCCCGCACAGTCTGACCGACTTGCGAATCACCAGGAGGATGATGTGGACCTGGAAGCCCTGGTGAACGATATGAATGCATCCCTGGAGAGCCTGTACTCGGCCTGCAGCATGCAGTCAGACACGGTGCCCCTCCTGCAGAATGGCCAGCATGCCCGCAGCCAGCCTCGGGCTTCAGGCCCTCCTCGGTCCATCCAGCCACAGGTGTCCCCGAGGCAGAGGGTGCAGCGCTCCCAGCCTGTGCACATCCTCGCTGTCAGGCGCCTTCAGGAGGAAGACCAGCAGTTTAGAACCTCATCTCTGCCGGCCATCCCCAATCCTTTTCCTGAACTCTGTGGCCCTGGGAGCCCCCCTGTGCTCACGCCGGGTTCTTTACCTCCGAGCCAGGCCGCCGCAAAGCAG Intervertebral disc degeneration 29476072 Circular RNA GRB10 as a competitive endogenous RNA regulating nucleus pulposus cells death in degenerative intervertebral disk. Guo W, Zhang B, Mu K, Feng SQ, Dong ZY, Ning GZ, Li HR, Liu S, Zhao L, Li Y, Yu BB, Duan HQ, Sun C, Li YJ. Cell Death Dis. 2018 circ-GRB10 was significantly downregulated in intervertebral disc degeneration (IDD) nucleus pulposus (NP) tissues compared with normal NP tissues. microarray, qRT-PCR intervertebral disc degeneration (IDD) nucleus pulposus (NP) tissues, normal NP tissues Overexpression of circ-GRB10 inhibited NP cell apoptosis. circ-GRB10 could sequester miR-328-5p, which could potentially lead to the upregulation of target genes related to cell proliferation via the ErbB pathway. circ-GRB10/miR-328-5p/ERBB2 signaling pathway is involved in IDD development, suggesting that circ-GRB10 might be a novel therapeutic target for IDD. loss of function, gain of function nucleus pulposus cells intervertebral disc degeneration (IDD) nucleus pulposus (NP) tissues, normal NP tissues miR-328-5p circRNA-miRNA nucleus pulposus cells FISH, luciferase reporter assay These data suggest that miR-328-5p directly targets circ-GRB10 in vitro. ERBB2 hsa_circ_0081108 circRNA homo sapiens COL1A2 hsa_circ_0081108 GGACACAATGGTCTGGATGGATTGAAGGGACAGCCCGGTGCTCCTGGTGTGAAGGGTGAACCTGGTGCCCCTGGTGAAAATGGAACTCCAGGTCAAACAGGAGCCCGTGGGCTTCCTGGTGAGAGAGGACGTGTTGGTGCCCCTGGCCCAGCTGGTGCCCGTGGCAGTGATGGAAGTGTGGGTCCCGTGGGTCCTGCTGGTCCCATTGGGTCTGCTGGCCCTCCAGGCTTCCCAGGTGCCCCTGGCCCCAAGGGTGAAATTGGAGCTGTTGGTAACGCTGGTCCTGCTGGTCCCGCCGGTCCCCGTGGTGAAGTGGGTCTTCCAGGCCTCTCCGGCCCCGTTGGACCTCCTGGTAATCCTGGAGCAAACGGCCTTACTGGTGCCAAGGGTGCTGCTGGCCTTCCCGGCGTTGCTGGGGCTCCCGGCCTCCCTGGACCCCGCGGTATTCCTGGCCCTGTTGGTGCTGCCGGTGCTACTGGTGCCAGAGGACTTGTTGGTGAGCCTGGTCCAGCTGGCTCCAAAGGAGAGAGCGGTAACAAGGGTGAGCCCGGCTCTGCTGGGCCCCAAGGTCCTCCTGGTCCCAGTGGTGAAGAAGGAAAGAGAGGCCCTAATGGGGAAGCTGGATCTGCCGGCCCTCCAGGACCTCCTGGGCTGAGAGGTAGTCCTGGTTCTCGTGGTCTTCCTGGAGCTGATGGCAGAGCTGGCGTCATGGGCCCTCCTGGTAGTCGTGGTGCAAGTGGCCCTGCTGGAGTCCGAGGACCTAATGGAGATGCTGGTCGCCCTGGGGAGCCTGGTCTCATGGGACCCAGAGGTCTTCCTGGTTCCCCTGGAAATATCGGCCCCGCTGGAAAAGAAGGTCCTGTCGGCCTCCCTGGCATCGACGGCAGGCCTGGCCCAATTGGCCCAGCTGGAGCAAGAGGAGAGCCTGGCAACATTGGATTCCCTGGACCCAAAGGCCCCACTGGTGATCCTGGCAAAAACGGTGATAAAGGTCATGCTGGTCTTGCTGGTGCTCGGGGTGCTCCAGGTCCTGATGGAAACAATGGTGCTCAGGGACCTCCTGGACCACAGGGTGTTCAAGGTGGAAAAGGTGAACAGGGTCCCCCTGGTCCTCCAGGCTTCCAGGGTCTGCCTGGCCCCTCAGGTCCCGCTGGTGAAGTTGGCAAACCAGGAGAAAGGGGTCTCCATGGTGAGTTTGGTCTCCCTGGTCCTGCTGGTCCAAGAGGGGAACGCGGTCCCCCAGGTGAGAGTGGTGCTGCCGGTCCTACTGGTCCTATTGGAAGCCGAGGTCCTTCTGGACCCCCAGGGCCTGATGGAAACAAGGGTGAACCTGGTGTGGTTGGTGCTGTGGGCACTGCTGGTCCATCTGGTCCTAGTGGACTCCCAGGAGAGAGGGGTGCTGCTGGCATACCTGGAGGCAAGGGAGAAAAGGGTGAACCTGGTCTCAGAGGTGAAATTGGTAACCCTGGCAGAGATGGTGCTCGTGGTGCTCCTGGTGCTGTAGGTGCCCCTGGTCCTGCTGGAGCCACAGGTGACCGGGGCGAAGCTGGGGCTGCTGGTCCTGCTGGTCCTGCTGGTCCTCGGGGAAGCCCTGGTGAACGTGGTGAGGTCGGTCCTGCTGGCCCCAATGGATTTGCTGGTCCTGCTGGTGCTGCTGGTCAACCTGGTGCTAAAGGAGAAAGAGGAGCCAAAGGGCCTAAGGGTGAAAACGGTGTTGTTGGTCCCACAGGCCCCGTTGGAGCTGCTGGCCCAGCTGGTCCAAATGGTCCCCCCGGTCCTGCTGGAAGTCGTGGTGATGGAGGCCCCCCTGGTATGACTGGTTTCCCTGGTGCTGCTGGACGGACTGGTCCCCCAGGACCCTCTGGTATTTCTGGCCCTCCTGGTCCCCCTGGTCCTGCTGGGAAAGAAGGGCTTCGTGGTCCTCGTGGTGACCAAGGTCCAGTTGGCCGAACTGGAGAAGTAGGTGCAGTTGGTCCCCCTGGCTTCGCTGGTGAGAAGGGTCCCTCTGGAGAGGCTGGTACTGCTGGACCTCCTGGCACTCCAGGTCCTCAGGGTCTTCTTGGTGCTCCTGGTATTCTGGGTCTCCCTGGCTCGAGAGGTGAACGTGGTCTACCAGGTGTTGCTGGTGCTGTGGGTGAACCTGGTCCTCTTGGCATTGCCGGCCCTCCTGGGGCCCGTGGTCCTCCTGGTGCTGTGGGTAGTCCTGGAGTCAACGGTGCTCCTGGTGAAGCTGGTCGTGATGGCAACCCTGGGAACGATGGTCCCCCAGGTCGCGATGGTCAACCCGGACACAAGGGAGAGCGCGGTTACCCTGGCAATATTGGTCCCGTTGGTGCTGCAGGTGCACCTGGTCCTCATGGCCCCGTGGGTCCTGCTGGCAAACATGGAAACCGTGGTGAAACTGGTCCTTCTGGTCCTGTTGGTCCTGCTGGTGCTGTTGGCCCAAGAGGTCCTAGT Diabetes Retinopathy 29288268 Identification and Characterization of Circular RNAs as a New Class of Putative Biomarkers in Diabetes Retinopathy. Zhang SJ, Chen X, Li CP, Li XM, Liu C, Liu BH, Shan K, Jiang Q, Zhao C, Yan B. Invest Ophthalmol Vis Sci. 2017 Upregulated in diabetic human retinas compared to nodiabetic retinas. microarray, qRT-PCR diabetic human retinas, nodiabetic retinas hsa_circ_0081146 circRNA homo sapiens COL1A2 hsa_circ_0081146 GGGGAACGCGGTCCCCCAGGTGAGAGTGGTGCTGCCGGTCCTACTGGTCCTATTGGAAGCCGAGGTCCTTCTGGACCCCCAGGGCCTGATGGAAACAAGGGTGAACCTGGTGTGGTTGGTGCTGTGGGCACTGCTGGTCCATCTGGTCCTAGTGGACTCCCAGGAGAGAGGGGTGCTGCTGGCATACCTGGAGGCAAGGGAGAAAAGGGTGAACCTGGTCTCAGAGGTGAAATTGGTAACCCTGGCAGAGATGGTGCTCGTGGTGCTCCTGGTGCTGTAGGTGCCCCTGGTCCTGCTGGAGCCACAGGTGACCGGGGCGAAGCTGGGGCTGCTGGTCCTGCTGGTCCTGCTGGTCCTCGGGGAAGCCCTGGTGAACGTGGTGAGGTCGGTCCTGCTGGCCCCAATGGATTTGCTGGTCCTGCTGGTGCTGCTGGTCAACCTGGTGCTAAAGGAGAAAGAGGAGCCAAAGGGCCTAAGGGTGAAAACGGTGTTGTTGGTCCCACAGGCCCCGTTGGAGCTGCTGGCCCAGCTGGTCCAAATGGTCCCCCCGGTCCTGCTGGAAGTCGTGGTGATGGAGGCCCCCCTGGTATGACTGGTTTCCCTGGTGCTGCTGGACGGACTGGTCCCCCAGGACCCTCTGGTATTTCTGGCCCTCCTGGTCCCCCTGGTCCTGCTGGGAAAGAAGGGCTTCGTGGTCCTCGTGGTGACCAAGGTCCAGTTGGCCGAACTGGAGAAGTAGGTGCAGTTGGTCCCCCTGGCTTCGCTGGTGAGAAGGGTCCCTCTGGAGAGGCTGGTACTGCTGGACCTCCTGGCACTCCAGGTCCTCAGGGTCTTCTTGGTGCTCCTGGTATTCTGGGTCTCCCTGGCTCGAGAGGTGAACGTGGTCTACCAGGTGTTGCTGGTGCTGTGGGTGAACCTGGTCCTCTTGGCATTGCCGGCCCTCCTGGGGCCCGTGGTCCTCCTGGTGCTGTGGGTAGTCCTGGAGTCAACGGTGCTCCTGGTGAAGCTGGTCGTGATGGCAACCCTGGGAACGATGGTCCCCCAGGTCGCGATGGTCAACCCGGACACAAGGGAGAGCGCGGTTACCCTGGCAATATTGGTCCCGTTGGTGCTGCAGGTGCACCTGGTCCTCATGGCCCCGTGGGTCCTGCTGGCAAACATGGAAACCGTGGTGAAACTGGTCCTTCTGGTCCTGTTGGTCCTGCTGGTGCTGTTGGCCCAAGAGGTCCTAGTGGCCCACAAGGCATTCGTGGCGATAAGGGAGAGCCCGGTGAAAAGGGGCCCAGAGGTCTTCCTGGCTTAAAGGGACACAATGGATTGCAAGGTCTGCCTGGTATCGCTGGTCACCATGGTGATCAAGGTGCTCCTGGCTCCGTGGGTCCTGCTGGTCCTAGGGGCCCTGCTGGTCCTTCTGGCCCTGCTGGAAAAGATGGTCGCACTGGACATCCTGGTACAGTTGGACCTGCTGGCATTCGAGGCCCTCAGGGTCACCAAGGCCCTGCTGGCCCCCCTGGTCCCCCTGGCCCTCCTGGACCTCCAGGTGTAAGCGGTGGTGGTTATGACTTTGGTTACGATGGAGACTTCTACAGGGCTGACCAGCCTCGCTCAGCACCTTCTCTCAGACCCAAGGACTATGAAGTTGATGCTACTCTGAAGTCTCTCAACAACCAGATTGAGACCCTTCTTACTCCTGAAGGCTCTAGAAAGAACCCAGCTCGCACATGCCGTGACTTGAGACTCAGCCACCCAGAGTGGAGCAGTGGTTACTACTGGATTGACCCTAACCAAGGATGCACTATGGATGCTATCAAAGTATACTGTGATTTCTCTACTGGCGAAACCTGTATCCGGGCCCAACCTGAAAACATCCCAGCCAAGAACTGGTATAGGAGCTCCAAGGACAAGAAACACGTCTGGCTAGGAGAAACTATCAATGCTGGCAGCCAG gastric cancer 28831102 Circular RNAs expression profiles in human gastric cancer. Dang Y, Ouyang X, Zhang F, Wang K, Lin Y, Sun B, Wang Y, Wang L, Huang Q. Sci Rep. 2017 upregulated in GC microarray, qRT-PCR GC tissues and the pair-matched normal tissues hsa_circ_0081162 circRNA homo sapiens COL1A2 hsa_circ_0081162 GGACCTCCTGGCACTCCAGGTCCTCAGGGTCTTCTTGGTGCTCCTGGTATTCTGGGTCTCCCTGGCTCGAGAGGTGAACGTGGTCTACCAGGTGTTGCTGGTGCTGTGGGTGAACCTGGTCCTCTTGGCATTGCCGGCCCTCCTGGGGCCCGTGGTCCTCCTGGTGCTGTGGGTAGTCCTGGAGTCAACGGTGCTCCTGGTGAAGCTGGTCGTGATGGCAACCCTGGGAACGATGGTCCCCCAGGTCGCGATGGTCAACCCGGACACAAGGGAGAGCGCGGTTACCCTGGCAATATTGGTCCCGTTGGTGCTGCAGGTGCACCTGGTCCTCATGGCCCCGTGGGTCCTGCTGGCAAACATGGAAACCGTGGTGAAACTGGTCCTTCTGGTCCTGTTGGTCCTGCTGGTGCTGTTGGCCCAAGAGGTCCTAGTGGCCCACAAGGCATTCGTGGCGATAAGGGAGAGCCCGGTGAAAAGGGGCCCAGAGGTCTTCCTGGCTTAAAGGGACACAATGGATTGCAAGGTCTGCCTGGTATCGCTGGTCACCATGGTGATCAAGGTGCTCCTGGCTCCGTGGGTCCTGCTGGTCCTAGGGGCCCTGCTGGTCCTTCTGGCCCTGCTGGAAAAGATGGTCGCACTGGACATCCTGGTACAGTTGGACCTGCTGGCATTCGAGGCCCTCAGGGTCACCAAGGCCCTGCTGGCCCCCCTGGTCCCCCTGGCCCTCCTGGACCTCCAGGTGTAAGCGGTGGTGGTTATGACTTTGGTTACGATGGAGACTTCTACAGGGCTGACCAGCCTCGCTCAGCACCTTCTCTCAGACCCAAGGACTATGAAGTTGATGCTACTCTGAAGTCTCTCAACAACCAGATTGAGACCCTTCTTACTCCTGAAGGCTCTAGAAAGAACCCAGCTCGCACATGCCGTGACTTGAGACTCAGCCACCCAGAGTGGAGCAGTGGTTACTACTGGATTGACCCTAACCAAGGATGCACTATGGATGCTATCAAAGTATACTGTGATTTCTCTACTGGCGAAACCTGTATCCGGGCCCAACCTGAAAACATCCCAGCCAAGAACTGGTATAGGAGCTCCAAGGACAAGAAACACGTCTGGCTAGGAGAAACTATCAATGCTGGCAGCCAG Diabetes Retinopathy 29288268 Identification and Characterization of Circular RNAs as a New Class of Putative Biomarkers in Diabetes Retinopathy. Zhang SJ, Chen X, Li CP, Li XM, Liu C, Liu BH, Shan K, Jiang Q, Zhao C, Yan B. Invest Ophthalmol Vis Sci. 2017 Upregulated in diabetic human retinas compared to nodiabetic retinas. microarray, qRT-PCR diabetic human retinas, nodiabetic retinas hsa_circRNA_104433 circRNA homo sapiens ARPC1B hsa_circ_0081342 AGATTGCCATCTGCCCCAACAACCATGAGGTGCATATCTATGAAAAGAGCGGTGCCAAATGGACCAAGGTGCACGAGCTCAAGGAGCACAACGGGCAGGTGACAGGCATCGACTGGGCCCCCGAGAGTAACCGTATTGTGACCTGCGGCACAGACCGCAACGCCTACGTGTGGACGCTGAAGGGCCGCACATGGAAGCCCACGCTGGTCATCCTGCGGATCAACCGGGCTGCCCGCTGCGTGCGCTGGGCCCCCAACGAGAACAAGTTTGCTGTGGGCAGCGGCTCTCGTGTGATCTCCATCTGTTATTTCGAGCAGGAGAATGACTGGTGGGTTTGCAAGCACATCAAGAAGCCCATCCGCTCCACCGTCCTCAGCCTGGACTGGCACCCCAACAATGTGCTGCTGGCTGCCGGCTCCTGTGACTTCAAGTGTCG papillary thyroid carcinoma 28288173 Microarray profiling of circular RNAs in human papillary thyroid carcinoma. Peng N, Shi L, Zhang Q, Hu Y, Wang N, Ye H. PLoS One. 2017 upregulated microarray, qRT-PCR PTC tumors, matching contralateral normal samples, benign thyroid lesions (i.e., follicular adenoma samples and multinodular goiter samples) hsa-miR-497-5p, hsa-miR-545-3p, hsa-miR-636, hsa-miR-15a-5p, hsa-miR-335-3p circRNA-miRNA predicted hsa_circ_0082081 circRNA homo sapiens CADPS2 hsa_circ_0082081 CTTAACAAACAACAGTTGCAGTTACTGAAAGAACGGTTCCAGGCCTTCCTCAATGGGGAAACCCAAATTGTAGCTGACGAAGCATTTTGCAACGCAGTTCGGAGTTATTATGAGGTTTTTCTAAAGAGTGACCGAGTGGCCAGAATGGTACAGAGTGGAGGGTGTTCTGCTAATGACTTCAGAGAAGTATTTAAGAAAAACATAGAAAAACGTGTGCGGAGTTTGCCAGAAATAGATGGCTTGAGCAAAGAGACAGTGTTGAGCTCATGGATAGCCAAATATGATGCCATTTACAGAGGTGAAGAGGACTTGTGCAAACAGCCAAATAGAATGGCCCTAAGTGCAGTGTCTGAACTTATTCTGAGCAAGGAACAACTCTATGAAATGTTTCAGCAGATTCTGGGTATTAAAAAACTGGAACACCAGCTCCTTTATAATGCATGTCAGCTGGATAACGCAGATGAACAAGCAGCCCAGATCAGAAGGGAACTTGATGGCCGGCTGCAATTGGCAGATAAAATGGCAAAGGAAAGAAAATTCCCCAAATTTATAGCAAAAGATATGGAGAATATGTATATAGAAGAGTTGCGGTCTTCAGTGAATTTGCTAATGGCCAATTTGGAAAGTCTTCCAGTTTCGAAAGGTGGTCCGGAATTTAAATTACAAAAATTAAAACGTTCACAGAACTCTGCATTTTTGGACATAGGAGATGAGAATGAGATTCAGCTGTCAAAGTCCGACGTGGTACTGTCATTCACCTTAGAGATTGTCATAATGGAAGTGCAAGGCCTGAAGTCAGTTGCTCCCAATCGAATTGTTTACTGTACAATGGAAGTGGAAGGAGAAAAACTTCAGACAGACCAGGCCGAAGCCTCAAGGCCACAATGGGGGACTCAAGGAGATTTCACCACCACCCATCCTCGGCCTGTGGTCAAAGTGAAACTCTTCACAGAAAGCACTGGAGTTCTGGCCCTGGAAGATAAAGAACTGGGAAGGGTGATATTATACCCAACTTCTAATAGCTCCAAATCAGCTGAATTACACCGAATGGTAGTTCCAAAAAATAGCCAGGATTCTGACTTAAAAATCAAACTGGCAGTGCGAATGGATAAACCAGCACATATGAAGCATAGTGGATATCTGTATGCCCTTGGACAGAAGGTTTGGAAAAGATGGAAAAAACGTTACTTTGTTCTAGTTCAGGTTAGCCAATATACCTTTGCTATGTGCAGTTATAGAGAAAAGAAGTCTGAACCACAAGAATTAATGCAGCTTGAAGGCTATACTGTGGATTATACCGATCCCCACCCAGGCCTTCAGGGTGGTTGTATGTTCTTTAATGCTGTTAAAGAAGGAGATACTGTAATCTTTGCCAGTGATGATGAACAGGACAGAATATTATGGGTTCAAGCCATGTATAGGGCCACAGGTCAATCATATAAACCAGTTCCTGCAATTCAAACCCAGAAACTGAATCCTAAAGGAGGAACTCTCCATGCAGATGCTCAGCTTTGTAAGTTTTGTTAAAAAATAATTTGATTATCAATTAATAGCCTTAATAAGATATAAAATTGAGGCAAATGTATTCAGTATTATAGTTTACATCATTAATTGATTCCTAATTAAATGAAAATAGTTCATATTAGTAGTCACATAATCACTTATCTAATTTTTCACATAAATCTGGAGTAAATGGTACGTGTGGTTTCCAATCATGGATTTGTCAAGCATTAGGGTATTTCTAGAAATCTCAAGAGCACATAAGAAAATTCTCCAAAACTTCTCAAAGGAAAATTTAATTTAGTTTATTGTGATTTTTGACTTAAGTCTCCTATAGATATGGAAAAAGTATTGCAAAATCAAATTTGCTTTGATAGGATTTCAGAATACCAAAATGATGAACCATTACCTTCTAGAATTGTTCTTAATACCCCAGAAGGATAATAGGTCTATTTTTTTGTTGTAGATTGATAAAAATAATAAGTCATAAAGCCAACTTTTTTCCCCTTGTACCTTAAAGACATGTCACTTTTTGAATGCTACCTTAAGTTGTTAAGAACTAAATTTTTAATTTTAAATGACTGATGCTTAATAATTATGGAATAATGGTCAAAACATCTTCAAACCTAGCTTTGATAATCACTAAACCAAGTGTTTTAACTTGTTGTACTCCTTTACAAAGCTTATCCTGTTTTACCTGTAATAAATATTTGTCTTTAACTTTCAGCTCAACTTGTGGCTTTTTATTCTTGAGATTCTTCTCAAAGGGAATAACATCTTGACATGCATTATTTTCTTCTGCTTTTCATGCATCAAGTAACTATTCTCTTCTCTTTTTAGATACCCTTCAGTATCATTTCTGGGCATCCTAAACAAAGGCACTTTAGTTCAAATAATTAAATGTGAACCATGAGCTTTTTATTTCTTTATTTTAGAAACCACAGACCATACTCATAGATTATCGTAATTATTTTGGGGCATATCTTTTATATGTAGTGAAAACTATTTAGGAATATTATAAATTTTTTCATTGATTTAAAATTTCTTCTTTAAAATTAGTAGCATTGTCATCTTAAAAGGTAAAATAAAATAAAAAGAGCACATTCTGATGTTTTCACTGTATTTGAAAATTTAACTCGCTGCTGCTGCCTTCCTCTCACCCTCTGGGTAATACACATAGAGTATGGCACAGCAGATAAGAGTGTTTCATCAGAGCTAAGGTGTACAGAAGTGTAACTTTATTTTTCTACAATTGAACATATCTTAAATTTTAATTTCTAATGTTGCCAAAAAACTTTAACTCGCTAATTCAAAACAACTGAGTCACAGATTATAATTCAATTAATTCAAGATTCTTCCCCCTACTCTTCTTCCATGTGATCCATAGTAAATTAAGTTTCAGAGGGATTGCATAAAACTGTGATATCATTGAATGTAACATCTAGCCTAAGACTATTCTCTGTTCACATGGGCTTAGGCATGACTTCTGTCATTGATTTCATTACTTATGTGCTGGTATGCACTGCTCGTCACCATGGACCTGCCAGGGCACCTGGCAATGAAGTCCATGTAGTCTGTGTCCTCCTTGGATCAACTCCAGACACCTATGAATTCCTTACATCATTTTCATCAGATTCTTGCCACAGTGGTACATAGTAACTTGTTGGGTATTCCCCAGCTATGCACAGGGGTGCTCACTCAGGCGTTTCTCTTGCAGCACAGCTCTTATCCACTGCTTCTTTCCTACTTCAAGTGCCAAATTGGGTATTTATCCCTGGACTGTGCCTGCATTGGGCATCAAAGTATAAGACTCCCTCAACCCCGGGTAGAACTTTTTTCCTCTGGAGCTCTGTTCATTGCTCACCCCCAGCACAACATTAACTCAAGTCAAATCTCTTCCCAAAACCATTTTCTTCCATCCAGCTGATCTATTTTTTTCCCTCCGAGTTTTGATTCTTGTTGTTGAAAACCAAGTTTTTATAAATTTGTTTCTTACCTCTCCATAGGCCAGTCTCTGTCCCTTCCCCTATAAGCTACAGTTCTACAGCATTTAATGTGAATTTCCTGTGTTTTTCATTTTGCAAATTTGCATTTTGTATGTGTGCATTTAGCGTCAATCTCATAAATGGTTTTGTATTCTTTGTCATATTCAGTCTTACTGTTTTTGTTCATCTCTATGTTTTTAAAATTTATCCATGTTTTTATGAATACATCTAATCTCATTCTTCTGATTACTGCATACCATGTAAGTGGGCTTCTGTCTTATGTTACCTGGTCTACTGCACATTTTATTTCTATTCACTCCTCCAGAGATGGAAACATAGAATGCCTCCAGATCCATACCTGTGTAATGTTCAGTTGTCCCAGCCATGACTATGAAATATCCTTTCATTTATTCAAATCTGAGTCCTTTACATTTTAATAATTTTCCATAGAGCTCTTTTTATTCTTGGTTAAGCTAATTTCTAAGCCTTTCATACTTTCCTTGCTATTGCATCTTATATTTTTTATTATATTTTCTAATTGACTATTGCTCATATAGAGAAATGCTATTTTCATGTGCTTTTTTGCTATCCATATTTATTCTTTGGTTATGTATCTCTGCACATACCTTGCCTAATTTGTAATTAGGCTATTTTCTTATTGGGTTTTGAGAGGTCTTTATACAGGCATACCTAGGAGATATTGTGGGTTCAGTTCCAGACCACTGCAATAAGATGAATATCTCAATAAAGTGAGTCACACAAATTCTTTGGTTTCCCAGTGTGTATAAAAGTTATGTTTGGCCGGCGCAGTGGCTCAAGCCTGTAATCCTAGCACTTTGGGAGGTCGAGGTGGGGGGGATCTCTTCAGTTCAGGAGTTCGAGACCAGACTGGGCAACATGATGAAACCCTGTATCTACAAAAAATGCAAAATTAGCTGAGCATGGTGGTACGTGGCTGTAGTCCCAGCACTTGGGAGGCTTGAAGTAGGAGAACTGCTTGAACCCGAGGGGTGGAGGTTGCAGTGAAATAGCGCCACTGCACTCCAGCCTGGGCGATAGAGTGAAACCCTGTCTCAAAAAAAAAAAAAAAAAAAAAAGTTATGTTTATACTACACTGTAGTGTATTAAGCATGCACTAGCATCATGTCTAAAACATAATTTTAAAATTCTTTATTGCTAAAAATAATCACCTGAGACTTCAGTGATTATAGTATTTTTGCTGGTAGAGGGTCTTGCCTCAACATTGATGGCTGCTGACCGATCAGGTTGCTGGTTGTTGAAGGTTGGTGTGGATGTGGCAATTTCTTAAAATAAGACAAGGATGAAGTTTGCTGCAGTGACTGATTCTTTCACGAAAGATTTTCTGGTAGCATGTGATGCTGTTTGCTATCATTTTGCCCAAAGTAGAACTTCTTTGAAAATTGGAGTCAATCCTCTAAAACTTTACCTCTGCTTTACGAACTAAGTTTATGTAATATCCTAAATCATTTGTTGTCCTTTCAACAATGTTCACAGCATCTTCACCAGAAGTAGATTCCATCTCAAAAATCACTTTCTTTGCTTCACCCAAAGGAACCAACTTCTTATCTGTTCAAGTTTTATCATGAGATTGCAGCAATTCAGTCACATCTTCAGGCTGCACTTTTAATTCTGGTTCTTTTGCTATTTTCATGACATCTGCAGTGACTTCCTCCACTCAAGTCTTCAATCCCTTAAAGTTATCCCTGAGGGTTGGAATCAACTTCCTCCAAACTCCTGTAAATGTTGATATTTTTACCTCCGCCCAAGAATCACAAATGTTCTTAATGGCATTTGGAATGATGAATCCTTTCCAGGTTTTCAATTTACTTTTCCCAGATGTCTCATAGGAATTACTATGTATGGCAGCTATAGCCTTATAAAATGTATTTCTTAAATAATAAGACTTGAAAGTTGAAATTACTCCTTGATCTGTGGGCTGCAGAATGGATGTTGGGTTAGCAAGCATGAAAACAACATTAATCTCCTTGTACATCTCCAGCAGAGCTCTTGAGCAACTAGATGCTATGTCAGTGAGCAATAATGCTTCCAACAGATTCTTTTGTTCTAGCATCAGGCCTCAGCAGTGGACTTAAAATATTCAGTAAACTATGCTGTAAACAGATGCACCATCATCTGGGCTTGTTCTTTCAGTTATAGAGCACAGAACAGGGTTGATGTAGCATAGTTTTTAAGGGCTCTGGGATTTTCAAAATGGTTAATAAACATTGGCTTCAACTTAAAGTCACCAGCTGCATTAGCCACTAACAAGAGAGCCTGTACTCTGAAGCTTTGAAGCCAAGCATTGACTTCTCTCTAACTGCGAAAGTCCTGGATGGCATCTTCTTCCAATAGAAGATTATTTTGTCTACACTAAAAATCTGTTATTTAGCATAGCTAACTTCATCAATGATCTTAGCTGGATCTTTTGGATAACTTATTGCCATTTCTGCATCAACCCTTGCTGTTTCACCTTGTACTTTTATGTAATAGAGATGGCTTCTTTTCCTTAACCCTAATGAGCTGACCTCTGCTGGCTTCACAGTTTGCAGAGGCTTCTTCACCTCTCTCAGCTGTCATAGAATCGAAGAAAGGCAGGGCCTTGCTCTGGATTAGGCTTTGGTTTAAGGGAATATTGTGGCTGGTTTGATCTATCCAGACCATTCAAACTTTCTTCATATCAGCAATAAGGCTGTTTTGCTTTCTTATTATTTGTGTGTTCACTGGAGTAGCAACTTTAATTTACTGCAACAACTTTTCCTTTGCATTCACAACTTAGCTACTTGGTGCAAAAGGCCTCGCTTTCAGCCTATCTTGGCTTTTGACATGCCTTGCTCACTAAGCATGATCATTTGTAGCTTTTAATTTAAAGTGAGGGAGATGGGATTCTTTCATTCATTTGAACACTTAGAGATCATTTCAGGTTGTTAGTTAGCCTAATTTTAATATTGTTGTGTGTCAGGAAATAGGGAGGCCCAAGAAAAGGGAGAGAGATGGGGAACAGTCAGAACACATATAACATTTATTAAGTTTACCATCTTATATGGGTGTAGTTTGTGGCACCCCAAAACAATTACAATAATATCAAAGATCACTTTCCACAGATGACCGTGATAGATCTACTAATAATGAAAAAGTTGGAAATACTGTGAGAATTACCATAACATGAAACAGTCATGATATGAGCACGTCATGATATGAGCACGTGTTGTTAAAAAAGTGACACCATGGACTTGCTTGACACAGGGTTGCCACGAACTTTCAATTTATGAAAAACACATCTGCAAAGCACAATAAAATGAAGTTTCCCTGTGTGTTCTGGATACAAGATGTTTGTCAGATACGTGATTTGCAAATATTTTCTCCTAATCTATGGCTTGTCTTTTCACATCTCTTAATAGTGACTTTCAGAAAAAAAAAAAAAGAAATTCTTAATTTTGATGAAGTCCATTTTATCAATTTTTTTCATAGTTGTGCTTTTGATGTTATAACTAAAGGATCTTTGCCTAACCCAAATTGCAAACATTTTCTCCTTTGCTTTCTTCTAGAAATTTTACAATTTTGGCGTTTACATTTTACAACCATTTTCAGTTAATTTTTATATATGGTGAGAGGTATCCATCAGTATTTCTGGATGGCATATGGATGTCCAGTTGTTCTAACACAAAGAGTTGAAGAGATTATCGTACCCTGAATTGCCCTTGCATATTTGTGAAAAATCAATTAACTACATATGAGTTTATTTCTGGGCTATCCTTTCTTTGGTCAGTTTATCTATCTTAATATTATTACCACACTGTCTTGATTACTGTAGCTTGGTAAATCTTACAGTTAGGTAGTCCAAGTCCTCCAAATTGATTTCTCTTATTCAAAAGTATTTTGGCTATTCTATGTCCTTTGCATTTCTCTATGAATTTTTAAAATAAGTTTATTCACTTTTAATTGACAAATAATTGTTTATATATATGGGGTACAATGTAAATTTTTAAAACATCTTGACATTCCTTGCTGGAGATTTTACTGGGAATGCCTTCAATCTATAGGTCAGTCCTTGGAAAATTTTGGAAAACTGACTTCTTAATATTGAGTCTTCCAATCTGTGAATACCATGTATCACTTCATTTGTTTAGGTAGTCTTTAGTTTCTCTTTGGGATGTTTGTAGTTTTCAGTGAACAGATCTAGCACATCTTTTGTCAGATTTATTTCTAGGTATTTCATCTTTGTTGCTTTAGTAAATGGAATTTTTTATTTCAGTCCAATTGTTTTGTTATCTTTGTGATTGCTTTAGAATTTAAAGTATACCCTTTAAATTTATTATATATCTTCATGTATAGTATGCACACTTTACAATAGTAAACTTCTATTTCTCCTCTCTTGGCTTTTGCACTATTCTTGTCATATATTTTACTTCTATATATGTGGTAAATCCCACAATACATTGCTATTATGATTATTGCCTTAGTCAATATCTTTTAAATAAATTAAAAGTGAAAGAAAAATGTTATGTACATGTCCATTTTGTACATGTCCATTATGTACATGTTATGTACATGTACATTACCATTTCCAGTGCCTTTCATCATCTAATATAGATATTTTCACTTCTTGGAGGACCTCCTTTGACTTTTCTTGTAGTGCAGATCTGCTGGTAATGAATACTTTTAGCTTCTTTATATACGAAAAAAAGTATTTATTTTACCCTCATTTTGAAGATATTTTTCTTTTAGTACTTTAAGGTGTTGCTCCACTTTCTTCTAGCTTGCATTTGTTTTTCCAATGAGAAATGTGCTGCTATTTTGGTTTTTTCCTCTATAAATAATGTCCTTTTTTCCTCTAGCTGCTTTAAAGATTTTTCTCTTTAACACTGTTTTTGAGCAATTTGATTATGATGTGCCTTGGTATAGTTTTCTTCATAAAAATGCTTGTTCTGAGACACAGTTAAGTTACTTGGAAACAATTCAATCCTCTCAAGCTTTGCTTTCAAGTTTTGTTAGGGAAGACCAAGCAGTGTTTAGTCCAGGATGCATTTTCCCCATTTCTGGACCAACATCTTTCTTAATACTCTAACTGATAACCTGTGAATTATGAGCTTTTATATTCTTGCTGCTGAAAAGCAGTGCTATTCTAGGCTGTGTGAGTTTGGGGCACTGTCCTCTCGAATCCTTTAGATTGCTTCTTTCCCTTTCTACACATGCATGAGCTGATGGGTAGTCAGCTGAATTCTTGGGGGAGGCCTTCTGTAGATCTTGAGAGTCTCTTGCTGGGCAGCTCTCTTCTCTCCAGTACTCTTTCCTACAAACTCTAGTTACTATCACCCTTCTGAACTGTCAGTTCCATCTTTTGAACTCAGGGAGACCACTGGGCTTTTCCTGGGTTCCTGTTGCTTGTGCCATGGGCTATAGAGTTTCTCCTGGCAGTAACCTGGAGTGACTGTAAGGCTCACCTTGTTTCCCGTCCCTCAGGAATCACGTTGCCCAACGTGCAGCGTTTAATAAACTTTTTGTAAATTTTTTTAGAATACTTAATTCAGGTAGGAGGTTAAGTTTATTCTCAATTATGCCATCATGACCAGAAGCAGAATTTTTTGTAAGTTAAAGCATGGTTTCTCAATTTCAACACTATTGACATTTTGGGCTAGATAATTATTTGTTTTGGGGCAGGGAGTGGAGTAAGGAACTTTTCCTGTGCGTTATGTAATGTTTTACAGCACCCCTGTCCTCTACCCACTAGGTATCAATAGTCTCCCACCTGGTCCCAGGTCAGACAACCAAAAATATCTCTGGACATTGCCAAATGTCCCAGAGGGTAGGGTTGCGGTTGGTGAGGAATCACCCCCAGTTGAGAACCACAGAATTACAGTGACTTAATAACTATTTTTTTTTAATCGCCATCCTCCTTCACTTGTGTTCCCATATTTTTTCTTAACATCCTGAGTGCAAGGAATGCCCGAGGAATGTGTTGAGCTCGTGGCTATTGTTGCTTGCACATAATGGCAAGAAAAGCAGGTAGGAACCACTAGCATAGAACTTTAAGACTGTGGCTGAATAATACAGAATTTTTTTAGACAGAGTCTGCCTCTGGAGAGAGAGGAAGTGCAGTGGTGCCATCTCGCCTCACTGAACCTCTGCCTCCCAGGTTCAAGCCATTCTCGTGCCTCAGCCTCCCAAGTAGCCTCCCAAGTAATCTCAGCAGCCGGGATTACAGGTGTGTGCCACCACACCCACCTAATTTTTGTATTTTTAGTAGAGACAGAGTTTCTCCATGTTGGCCAGGCTAGTCTCAAACTCCTGACCTCAGGTGATCTGCCAGCCTTGGCCTGCCAAAGTGCTGGGATTACAGGCATGAGCCACTGCACCTGCCTGTAACAAATAATAACAAAACCTTTCTATTATTCGATATCAATTTATTGTCAAGGCAGGACTGATCAGGCTATGGGATTCCCATGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTGTATGCTACCACACCTGCCTAATTTTTGTCTTTTTAATAGAGATGGGGTTTCTCCACGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTTATCTGCCCACCTCAGCTCCCGAAGTGCTGGGATTACAGGCATGAGCCACAGCGCCCAGCCCTATCATCTGTTTCTAACAAAACCTTTCTGTTATTTGATATCAATTTATTGTCAAGGCAGAATTGATCAGGCTATGAGAACTGAATTTACTTGTTATAACTAAAAAGGGAAACTGTTTCAATTTGTTAACAACAACTGACTTGTATTCCAGGCTGCTAGTAAAGTTTTAAATCAGGGCAGACCTCTGCTGACGTGAACCTGGGAGGCAGAGCTTGCAGTGAGCCACGTTCGCACCACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCCGTCAAAAAAAAAAAAAAAAAAAAAAAGAATGAAGAAAGAAAATGTTCTACCTCATCAGAATGAGGGTAGTGACCCTGAACTATCAGAGAAATGCCATGAATTCCTCCAGAGTTCCTCCAGAGAGTAGTTTCATCCATAGTATTTTCCTCCCTCCATTGACTTACATAATCAATTTTTGTTTTCTTTCCTGATGGTCTTTTAGAAAAACAACTTTTAAAATCATGAGTAGAAATTGAGAAAATAAAAAATTAAATGTCTAGTTGTATAAGTATATAGTTCCCAACCCATTTAAATATGCTTTGTTTCTCATTTCTTTGCTGACCTGTAGCTGGTAAAG coronary artery disease 28045102 Peripheral blood circular RNA hsa_circ_0124644 can be used as a diagnostic biomarker of coronary artery disease. Zhao Z, Li X, Gao C, Jian D, Hao P, Rao L, Li M. Sci Rep. 2017 We verified the 5 candidate biomarkers by qPCR in another independent cohort consisting of 30 control subjects (CADS = 0, n = 30) and 30 CAD patients with different CADS (CADS 1¨C22, n = 10; CADS 23¨C32, n = 10; CADS > 33, n = 10). The results confirmed the findings of the microarray analysis, as the levels of these 5 circRNAs were significantly increased in the CAD patients; there was a 2.7-fold change in the expression of hsa_circ_0124644, and 2.2-, 2.1-, 2.0-, and 2.1-fold changes in the expression levels of hsa_circ_0082081, hsa_circ_0113854, hsa_circ_0098964 and hsa-circRNA5974-1,respectively. qRT-PCR, microarray peripheral blood from 12 CAD patients and 12 controls hsa_circ_0082314 circRNA homo sapiens NRF1 hsa_circ_0082314 CGAAGCTGCCGCCCATGCTGTCGCCACCCTGGCTGAGGCCACCTTACAAGGTGGGGGACAGATCGTCTTGTCTGGGGAAACCGCAGCAGCCGTCGGAGCACTTACTGGAGTCCAAGATGCTAATG hepatocellular carcinoma 29144509 Circular RNA expression is suppressed by androgen receptor (AR)-regulated adenosine deaminase that acts on RNA (ADAR1) in human hepatocellular carcinoma. Shi L, Yan P, Liang Y, Sun Y, Shen J, Zhou S, Lin H, Liang X, Cai X. Cell Death Dis. 2017 upregulated more than fivefold as revealed by circRNA microarray after AR knocking down in MHCC-106h cells microarray, qRT-PCR MHCC-97h, LM3 and LO12 cells hsa_circ_0082452 circRNA homo sapiens EXOC4 hsa_circ_0082452 ATTTATTCAGGAGATTGAGCATGCTCTGGGTCTTGGCCCAGCCAAACAGTGTCCTCTTCGAGAGTTTCTCACCGTGTACATCAAAAACATCTTTCTCAATCAAGTCTTGGCTGAGATCAACAAGGAGATTGAAGGAGTCACTAAAACATCTGACCCTTTGAAGATTCTGGCCAACGCAGACACCATGAAGGTGCTGGGAGTGCAGCGGCCTCTCCTACAG osteosarcoma 29229385 Circular RNA hsa_circ_0001564 regulates osteosarcoma proliferation and apoptosis by acting miRNA sponge. Song YZ, Li JF. Biochem Biophys Res Commun. 2018 upregulated microarray, qRT-PCR OS tissues and adjacent non-tumor tissues, NHOst, MG63, Saos-2, HOS, and U2OS hsa_circ_0084021 circRNA homo sapiens PLEKHA2 hsa_circ_0084021 GTGAGCATAGCTACCCCAAAACAGAAACCAAAAACTCCATTTTGCTTTGTTATCAATGCCCTGTCTCAGAGATATTTCCTTCAAGCCAATGATCAGAAAGATATGAAGGACTGGGTTGAAGCCCTGAACCAAGCCAGCAAGATCACC Colorectal cancer 28656150 Microarray Analysis of Circular RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells. Xiong W, Ai YQ, Li YF, Ye Q, Chen ZT, Qin JY, Liu QY, Wang H, Ju YH, Li WH, Li YF. Biomed Res Int. 2017 down microarray, qRT-PCR CRR (chemoradiation resistance)-HCT116 and the parental HCT116 cells hsa_circ_0084720 circRNA homo sapiens SULF1 hsa_circ_0084720 GACCCTATCTGCAGATGTTCTGAATACCTCTGAGAATAGAGATTGATTATTCAACCAGGATACCTAATTCAAGAACTCCAGAAATCAGGAGACGGAGACATTTTGTCAGTTTTGCAACATTGGACCAAATACAATGAAGTATTCTTGCTGTGCTCTGGTTTTGGCTGTCCTGGGCACAGAATTGCTGGGAAGCCTCTGTTCGACTGTCAGATCCCCGAGGTTCAGAGGACGGATACAGCAGGAACGAAAAAACATCCGACCCAACATTATTCTTGTGCTTACCGATGATCAAGATGTGGAGCTGGGGTCCCTGCAAGTCATGAACAAAACGAGAAAGATTATGGAACATGGGGGGGCCACCTTCATCAATGCCTTTGTGACTACACCCATGTGCTGCCCGTCACGGTCCTCCATGCTCACCGGGAAGTATGTGCACAATCACAATGTCTACACCAACAACGAGAACTGCTCTTCCCCCTCGTGGCAGGCCATGCATGAGCCTCGGACTTTTGCTGTATATCTTAACAACACTGGCTACAGAACAGCCTTTTTTGGAAAATACCTCAATGAATATAATGGCAGCTACATCCCCCCTGGGTGGCGAGAATGGCTTGGATTAATCAAGAATTCTCGCTTCTATAATTACACTGTTTGTCGCAATGGCATCAAAGAAAAGCATGGATTTGATTATGCAAAGGACTACTTCACAGACTTAATCACTAACGAGAGCATTAATTACTTCAAAATGTCTAAGAGAATGTATCCCCATAGGCCCGTTATGATGGTGATCAGCCACGCTGCGCCCCACGGCCCCGAGGACTCAGCCCCACAGTTTTCTAAACTGTACCCCAATGCTTCCCAACACAT gastric cancer 28831102 Circular RNAs expression profiles in human gastric cancer. Dang Y, Ouyang X, Zhang F, Wang K, Lin Y, Sun B, Wang Y, Wang L, Huang Q. Sci Rep. 2017 upregulated in GC microarray, qRT-PCR GC tissues and the pair-matched normal tissues hsa_circ_0085144 circRNA homo sapiens PABPC1 hsa_circ_0085144 CTAACACATCAACACAGACAATGGGTCCACGTCCTGCAGCTGCAGCCGCTGCAGCTACTCCTGCTGTCCGCACCGTTCCACAGTATAAATATGCTGCAGGAGTTCGCAATCCTCAGCAACATCTTAATGCACAGCCACAAGTTACAATGCAACAGCCTGCTGTTCATGTACAAGGTCAGGAACCTTTGACTGCTTCCATGTTGGCATCTGCCCCTCCTCAAGAGCAAAAGCAAATGTTGG hepatocellular carcinoma 29144509 Circular RNA expression is suppressed by androgen receptor (AR)-regulated adenosine deaminase that acts on RNA (ADAR1) in human hepatocellular carcinoma. Shi L, Yan P, Liang Y, Sun Y, Shen J, Zhou S, Lin H, Liang X, Cai X. Cell Death Dis. 2017 upregulated more than fivefold as revealed by circRNA microarray after AR knocking down in MHCC-100h cells microarray, qRT-PCR MHCC-97h, LM3 and LO6 cells CircARSP91 circRNA homo sapiens PABPC1 hsa_circ_0085154 ACTCAGAACCGTGCTGCATACTATCCTCCTAGCCAAATTGCTCAACTAAGACCAAGTCCTCGCTGGACTGCTCAGGGTGCCAGACCTCATC hepatocellular carcinoma 29144509 Circular RNA expression is suppressed by androgen receptor (AR)-regulated adenosine deaminase that acts on RNA (ADAR1) in human hepatocellular carcinoma. Shi L, Yan P, Liang Y, Sun Y, Shen J, Zhou S, Lin H, Liang X, Cai X. Cell Death Dis. 2017 downregulated by AR in an ADAR1-dependent manner microarray, qRT-PCR MHCC-97h, LM3 and LO2 cells inhibit HCC tumor growth both in vitro and in vivo loss of function, gain of function HepG2, MHCC-97, SK-Hep1 male 6¨C8-week-old nude mice downregulated by AR in an ADAR1-dependent manner hsa_circ_0085159 circRNA homo sapiens PABPC1 hsa_circ_0085159 CGGAGCGTGCTTTGGACACCATGAATTTTGATGTTATAAAGGGCAAGCCAGTACGCATCATGTGGTCTCAGCGTGATCCATCACTTCGCAAAAGTGGAGTAGGCAACATATTCATTAAAAATCTGGACAAATCCATTGATAATAAAGCACTGTATGATACATTTTCTGCTTTTGGTAACATCCTTTCATGTAAGGTGGTTTGTGATGAAAATGGTTCCAAGGGCTATGGATTTGTACACTTTGAGACGCAGGAAGCAGCTGAAAGAGCTATTGAAAAAATGAATGGAATGCTCCTAAATGATCGCAAAGTATTTGTTGGACGATTTAAGTCTCGTAAAGAACGAGAAGCTGAACTTGGAGCTAGGGCAAAAGAATTCACCAATGTTTACATCAAGAATTTTGGAGAAGACATGGATGATGAGCGCCTTAAGGATCTCTTTGGCAAGTTTGGGCCTGCCTTAAGTGTGAAAGTAATGACTGATGAAAGTGGAAAATCCAAAGGATTTGGATTTGTAAGCTTTGAAAGGCATGAAGATGCACAGAAAGCTGTGGATGAGATGAACGGAAAGGAGCTCAATGGAAAACAAATTTATGTTGGTCGAGCTCAGAAAAAGGTGGAACGGCAGACGGAACTTAAGCGCAAATTTGAACAGATGAAACAAGATAGGATCACCAGATACCAGGGTGTTAATCTTTATGTGAAAAATCTTGATGATGGTATTGATGATGAACGTCTCCGGAAAGAGTTTTCTCCATTTGGTACAATCACTAGTGCAAAGGTTATGATGGAGGGTGGTCGCAGCAAAGGGTTTGGTTTTGTATGTTTCTCCTCCCCAGAAGAAGCCACTAAAGCAGTTACAGAAATGAACGGTAGAATTGTGGCCACAAAGCCATTGTATGTAGCTTTAGCTCAGCGCAAAGAAGAGCGCCAGGCTCACCTCACTAACCAGTATATGCAGAGAATGGCAAGTGTACGAGCTGTTCCCAACCCTGTAATCAACCCCTACCAGCCAGCACCTCCTTCAGGTTACTTCATGGCAGCTATCCCACAGACTCAGAACCGTGCTGCATACTATCCTCCTAGCCAAATTGCTCAACTAAGACCAAGTCCTCGCTGGACTGCTCAGGGTGCCAGACCTCATC hepatocellular carcinoma 29144509 Circular RNA expression is suppressed by androgen receptor (AR)-regulated adenosine deaminase that acts on RNA (ADAR1) in human hepatocellular carcinoma. Shi L, Yan P, Liang Y, Sun Y, Shen J, Zhou S, Lin H, Liang X, Cai X. Cell Death Dis. 2017 upregulated more than fivefold as revealed by circRNA microarray after AR knocking down in MHCC-98h cells microarray, qRT-PCR MHCC-97h, LM3 and LO4 cells hsa_circ_0085495 circRNA homo sapiens TMEM65 hsa_circ_0085495 TATTCATCCACAATGCGATACCTTTCATAGGGTTTGGCTTTTTGGATAATGCAATTATGATTGTTGCTGGAACCCATATTGAAATGTCTATTGGAATTATTTTGGGAATTTCAACTATGGCAGCTGCTGCTTTGGGAAATCTTGTGTCAGATCTAGCTGGACTTGGACTTGCAGGCTACGTTGAAGCATTGGCTTCCAGGTTAGGCCTGTCAATTCCTGATCTCACACCAAAGCAAGTTGACATGTGGCAAACACGTCTTAGTACACATTTG breast cancer 28803498 Screening circular RNA related to chemotherapeutic resistance in breast cancer. Gao D, Zhang X, Liu B, Meng D, Fang K, Guo Z, Li L. Epigenomics. 2017 up microarray, qRT-PCR MCF-7, ADM-resistant cell lines (MCF-7/ADM) hsa_circ_0085553 circRNA homo sapiens PVT1 hsa_circ_0085553 AATCCTGTTACACCTGGGATTTAGGCACTTTCAATCTGAAAAAATACATATCCTTTCAGCACTCTGGACGGACTTGAGAACTGTCCTTACGTGACCTAAAGCTGGAGTATTTTGAGATTGGAGAATTAAGAGCCAGTCTTGGTGCTCTGTGTTCACCTGGTTCATCTGAGGAGCTGCATCTACCCTGCCCATGCCATAGATCCTGCCCTGTTTGCTTCTCCTGTTGCTGCTAGTGGACATGAG gastric cancer 28639908 Circular RNAs play an important role in late-stage gastric cancer: Circular RNA expression profiles and bioinformatics analyses. Fang Y, Ma M, Wang J, Liu X, Wang Y. Tumour Biol. 2017 upregulated in GC microarray, qRT-PCR III stage gastric cancer and paired paracarcinoma tissue circPVT1 circRNA homo sapiens PVT1 hsa_circ_0085558 AAGGACAGAATAACGGGCTCCCAGATTCACAAGCCCCACCAAGAGGATCACCCCAGGAACGCTTGGAGGCTGAGGAGTTCACTGAGGCTACTGCATCTTGAGACTCAGGATGAAGACCCAGCTTGGGGCTGTCAAAGGTTTTTTGCATGTCTGACACCCATGACTCCACCTGGACCTTATGGCTCCACCCAGAAGCAATTCAGCCCAACAGGAGGACAGCTTCAACCCATTACGATTTCATCTCTGCCCCAACCACTCAGCAGCAAGCACCTGTTACCTGTCCACCCCCACCCCTTCCCCCAAACTGCCTTTGAAAAATCCCTAACCTATGAGCTTTGAATAAGATGAGTACGAACTTCATCGCCCACGTGGCGTGGCCGGCCTCGTGTCTATTAAATTCTTTTTCTACTA 24039610 Cell-type specific features of circular RNA expression. Salzman J, Chen RE, Olsen MN, Wang PL, Brown PO. PLoS Genet. 2013 HeLa RNA was treated with RNase R or a mock treatment, and then subjected to qPCR with isoform-specific primers. The fraction of linear and circular isoforms was normalized to the value measured in the mock treatment. All tested circular isoforms resisted RNase R. qRT-PCR HeLa hsa_circ_0085616 circRNA homo sapiens ASAP1 hsa_circ_0085616 ATATCCAGGAATGATTTTCAGAGTATTTGAGAAAATGAGAGGTGCAGATGGTTTTCACTGAGGCATGGTTTCAAATTTAAAGAGGATTATGGCCCAGAAATGGATGCCGGACCAGATCTCTGTCTCGGAGTTCATCGCCGAGACCACCGAGGACTACAACTCGCCCACCACGTCCAGCTTCACCACGCGGCTGCACAACTGCAGGAACACCGTCACGCTGCTGGAGGAG gastric cancer 28974900 Circular RNA hsa_circ_0000745 may serve as a diagnostic marker for gastric cancer. Huang M, He YR, Liang LC, Huang Q, Zhu ZQ. World J Gastroenterol. 2017 up-regulated in GC RNA-seq, qRT-PCR Human samples of GC tissues and paired adjacent non-tumor tissues hsa_circ_0086241 circRNA homo sapiens RFX3 hsa_circ_0086241 CCGAACAACAACGTATCCTTACACAGAGACACAGATGTACAGCCAAAATACTGGAGGGAATTACTTTGATACTCAAGGGAGTTCCGCCCAGGTGACTACCGTGGTCTCATCCCACAGTATGGTGGGCACTGGTGGGATTCAGATGGGCGTCACAGGAGGACAACTCATCAGCAGCTCTGGAGGAACCTATCTGATCGGCAACTCAATGGAGAATTCTGGTCACTCAGTGACACACACAACTCGGGCCTCCCCAGCGACA breast cancer 28803498 Screening circular RNA related to chemotherapeutic resistance in breast cancer. Gao D, Zhang X, Liu B, Meng D, Fang K, Guo Z, Li L. Epigenomics. 2017 up microarray, qRT-PCR MCF-7, ADM-resistant cell lines (MCF-7/ADM) hsa_circ_0087206 circRNA homo sapiens ALDH1A1 hsa_circ_0087206 ATTTTTGGACCAGTGCAGCAAATCATGAAGTTTAAATCTTTAGATGACGTGATCAAAAGAGCAAACAATACTTTCTATGGCTTATCAGCAGGAGTGTTTACCAAAGACATTGATAAAGCCATAACAATCTCCTCTGCTCTGCAGGCAGGAACAGTGTGGGTGAATTGCTATGGCGTGGTAAGTGCCCAGTGCCCCTTTGGTGGATTCAAGATGTCTGGAAATGGAAGAGAACT Diabetes Retinopathy 29288268 Identification and Characterization of Circular RNAs as a New Class of Putative Biomarkers in Diabetes Retinopathy. Zhang SJ, Chen X, Li CP, Li XM, Liu C, Liu BH, Shan K, Jiang Q, Zhao C, Yan B. Invest Ophthalmol Vis Sci. 2017 Upregulated in diabetic human retinas compared to nodiabetic retinas. microarray, qRT-PCR diabetic human retinas, nodiabetic retinas hsa_circ_0087215 circRNA homo sapiens ANXA1 hsa_circ_0087215 TGTTTCAGAAATACACCAAGTACAGTAAGCATGACATGAACAAAGTTCTGGACCTGGAGTTGAAAGGTGACATTGAGAAATGCCTCACAGCTATCG Diabetes Retinopathy 29288268 Identification and Characterization of Circular RNAs as a New Class of Putative Biomarkers in Diabetes Retinopathy. Zhang SJ, Chen X, Li CP, Li XM, Liu C, Liu BH, Shan K, Jiang Q, Zhao C, Yan B. Invest Ophthalmol Vis Sci. 2017 Upregulated in diabetic human retinas compared to nodiabetic retinas. microarray, qRT-PCR diabetic human retinas, nodiabetic retinas hsa_circ_0088088 circRNA homo sapiens HSDL2 hsa_circ_0088088 GAGGCTGGCAGGATGTACAGTTTTTATCACAGGTGCAAGCCGTGGCATTGGCAAAGCTATTGCATTGAAAGCAGCAAAGGATGGAGCAAATATTGTTATTGCTGCAAAGACCGCCCAGCCACATCCAAAACTTCTAGGCACAATCTATACTGCTGCTGAAGAAATTGAAGCAGTTGGAGGAAAGGCCTTGCCATGTATTGTTGATGTGAGAGATGAACAGCAGATCAGTGCTGCAGTGGAGAAAGCCATCAAGAAATTTGGAGGAATTGATATTCTGGTAAATAATGCCAGTGCCATTAGTTTGACCAATACATTGGACACACCTACCAAGAGATTGGATCTGATGATGAACGTGAACACCAGAGGCACCTACCTTGC osteosarcoma 29229385 Circular RNA hsa_circ_0001564 regulates osteosarcoma proliferation and apoptosis by acting miRNA sponge. Song YZ, Li JF. Biochem Biophys Res Commun. 2018 upregulated microarray, qRT-PCR OS tissues and adjacent non-tumor tissues, NHOst, MG63, Saos-2, HOS, and U2OS hsa_circ_0089372 circRNA homo sapiens ADAMTS13 hsa_circ_0089372 GGGATGCTCTGTGCAGACACATGTGCCGGGCCATTGGCGAGAGCTTCATCATGAAGCGTGGAGACAGCTTCCTCGATGGGACCCGGTGTATGCCAAGTGGCCCCCGGGAGGACGGGACCCTGAGCCTGTGTGTGTCGGGCAGCTGCAGGACATTTGGCTGTGATGGTAGGATGGACTCCCAGCAGGTATGGGACAGGTGCCAGGTGTGTGGTGGGGACAACAGCACGTGCAGCCCACGGAAGGGCTCTTTCACAGCTGGCAGAGCGAGAG male infertile diseases 27958373 Identification and characterization of human testis derived circular RNAs and their existence in seminal plasma. Dong WW, Li HM, Qing XR, Huang DH, Li HG. Sci Rep. 2016 To validate these predicted circRNAs, 55 circRNAs of different abundance and lengths were randomly chosen for subsequent RT-PCR validation. Divergent primers were designed for circRNA detection. Among the 55 circRNAs, 30 of them could be specifically amplified. qRT-PCR human testis hsa_circ_0089548 circRNA homo sapiens NOTCH1 hsa_circ_0089548 GGTACACGGGGACGCACTGCGAGGTGGACATCGATGAGTGCGACCCCGACCCCTGCCACTACGGCTCCTGCAAGGACGGCGTCGCCACCTTCACCTGCCTCTGCCGCCCAGGCTACACGGGCCACCACTGCGAGACCAACATCAACGAGTGCTCCAGCCAGCCCTGCCGCCACGGGGGCACCTGCCAGGACCGCGACAACGCCTACCTCTGCTTCTGCCTGAAGGGGACCACAGGACCCAACTGCGAGATCAACCTGGATGACTGTGCCAGCAGCCCCTGCGACTCGGGCACCTGTCTGGACAAGATCGATGGCTACGAGTGTGCCTGTGAGCCGGGCTACACAGGGAGCATGTGTAACATCAACATCGATGAGTGTGCGGGCAACCCCTGCCACAACGGGGGCACCTGCGAGGACGGCATCAATGGCTTCACCTGCCGCTGCCCCGAGGGCTACCACGACCCCACCTGCCTGTCTGAGGTCAATGAGTGCAACAGCAACCCCTGCGTCCACGGGGCCTGCCGGGACAGCCTCAACGGGTACAAGTGCGACTGTGACCCTGGGTGGAGTGGGACCAACTGTGACATCAACAACAATGAGTGTGAATCCAACCCTTGTGTCAACGGCGGCACCTGCAAAGACATGACCAGTGGCTACGTGTGCACCTGCCGGGAGGGCTTCAGCGGTCCCAACTGCCAGACCAACATCAACGAGTGTGCGTCCAACCCATGTCTGAACCAGGGCACGTGTATTGACGACGTTGCCGGGTACAAGTGCAACTGCCTGCTGCCCTACACAGGTGCCACGTGTGAGGTGGTGCTGGCCCCGTGTGCCCCCAGCCCCTGCAGAAACGGCGGGGAGTGCAGGCAATCCGAGGACTATGAGAGCTTCTCCTGTGTCTGCCCCACGGGCTGGCAAGGGCAGACCTGTGAGGTCGACATCAACGAGTGCGTTCTGAGCCCGTGCCGGCACGGCGCATCCTGCCAGAACACCCACGGCGGCTACCGCTGCCACTGCCAGGCCGGCTACAGTGGGCGCAACTGCGAGACCGACATCGACGACTGCCGGCCCAACCCGTGTCACAACGGGGGCTCCTGCACAGACGGCATCAACACGGCCTTCTGCGACTGCCTGCCCGGCTTCCGGGGCACTTTCTGTGAGGAGGACATCAACGAGTGTGCCAGTGACCCCTGCCGCAACGGGGCCAACTGCACGGACTGCGTGGACAGCTACACGTGCACCTGCCCCGCAGGCTTCAGCGGGATCCACTGTGAGAACAACACGCCTGACTGCACAGAGAGCTCCTGCTTCAACGGTGGCACCTGCGTGGACGGCATCAACTCGTTCACCTGCCTGTGTCCACCCGGCTTCACGGGCAGCTACTGCCAGCACGATGTCAATGAGTGCGACTCACAGCCCTGCCTGCATGGCGGCACCTGTCAGGACGGCTGCGGCTCCTACAGGTGCACCTGCCCCCAGGGCTACACTGGCCCCAACTGCCAGAACCTTGTGCACTGGTGTGACTCCTCGCCCTGCAAGAACGGCGGCAAATGCTGGCAGACCCACACCCAGTACCGCTGCGAGTGCCCCAGCGGCTGGACCGGCCTTTACTGCGACGTGCCCAGCGTGTCCTGTGAGGTGGCTGCGCAGCGACAAGGTGTTGACGTTGCCCGCCTGTGCCAGCATGGAGGGCTCTGTGTGGACGCGGGCAACACGCACCACTGCCGCTGCCAGGCGGGCTACACAGGCAGCTACTGTGAGGACCTGGTGGACGAGTGCTCACCCAGCCCCTGCCAGAACGGGGCCACCTGCACGGACTACCTGGGCGGCTACTCCTGCAAGTGCGTGGCCGGCTACCACGGGGTGAACTGCTCTGAGGAGATCGACGAGTGCCTCTCCCACCCCTGCCAGAACGGGGGCACCTGCCTCGACCTCCCCAACACCTACAAGTGCTCCTGCCCACGGGGCACTCAGGGTGTGCACTGTGAGATCAACGTGGACGACTGCAATCCCCCCGTTGACCCCGTGTCCCGGAGCCCCAAGTGCTTTAACAACGGCACCTGCGTGGACCAGGTGGGCGGCTACAGCTGCACCTGCCCGCCGGGCTTCGTGGGTGAGCGCTGTGAGGGGGATGTCAACGAGTGCCTGTCCAATCCCTGCGACGCCCGTGGCACCCAGAACTGCGTGCAGCGCGTCAATGACTTCCACTGCGAGTGCCGTGCTGGTCACACCGGGCGCCGCTGCGAGTCCGTCATCAATGGCTGCAAAGGCAAGCCCTGCAAGAATGGGGGCACCTGCGCCGTGGCCTCCAACACCGCCCGCGGGTTCATCTGCAAGTGCCCTGCGGGCTTCGAGGGCGCCACGTGTGAGAATGACGCTCGTACCTGCGGCAGCCTGCGCTGCCTCAACGGCGGCACATGCATCTCCGGCCCGCGCAGCCCCACCTGCCTGTGCCTGGGCCCCTTCACGGGCCCCGAATGCCAGTTCCCGGCCAGCAGCCCCTGCCTGGGCGGCAACCCCTGCTACAACCAGGGGACCTGTGAGCCCACATCCGAGAGCCCCTTCTACCGTTGCCTGTGCCCCGCCAAATTCAACGGGCTCTTGTGCCACATCCTGGACTACAGCTTCGGGGGTGGGGCCGGGCGCGACATCCCCCCGCCGCTGATCGAGGAGGCGTGCGAGCTGCCCGAGTGCCAGGAGGACGCGGGCAACAAGGTCTGCAGCCTGCAGTGCAACAACCACGCGTGCGGCTGGGACGGCGGTGACTGCTCCCTCAACTTCAATGACCCCTGGAAGAACTGCACGCAGTCTCTGCAGTGCTGGAAGTACTTCAGTGACGGCCACTGTGACAGCCAGTGCAACTCAGCCGGCTGCCTCTTCGACGGCTTTGACTGCCAGCGTGCGGAAGGCCAGTGCAA gastric cancer 28639908 Circular RNAs play an important role in late-stage gastric cancer: Circular RNA expression profiles and bioinformatics analyses. Fang Y, Ma M, Wang J, Liu X, Wang Y. Tumour Biol. 2017 upregulated in GC microarray, qRT-PCR III stage gastric cancer and paired paracarcinoma tissue hsa_circ_0089810 circRNA homo sapiens None hsa_circ_0089810 GGGATGACTTTGACTTAGGAGATGCTGTTGTTGATGGAGAAAATGGTGAGTATTTTCCTTTAATCTCTTCTGCTGCTGATCTGCTTATTATCACCCAATTATGATCATTTCAGAGAGAATTCTCCCATTTAAATTATAAAGGGAACCAGTTTTCACAGTGGAAACCTAGGGAATAGGTGTGTCGGTTTGTTCTTGCTGTTGTCGTTGGGTTTTTCTTTACAACCAGTACGTGTGCTTTTATTTTAAAACTCTTACAGTCTTTGGAAGGACATGAGACAAATGTGCCTACCCTGGCCAGGGCTGGCTTCACCAGCATGTGACCTGTGCAGTGGCACAGGACCCCATGGCATGTTGGTTTGGCATGGGAACCATACTGGTTTACTGCTCTGTTGCCGCCATCTTGGAATACTTAAGAAAATTTGAAAAATGGGTCCCACCTTTTTATTTTGGCCCTAGAAATTCTGTAGCTGGTGTGGACACCCGCTTTAATTTTTATTAAACATAGTTGACATTAAGAACTGTGGCTGAAAGTTGATGGGAGGAAACTGGCAGGAGACTGTGTGTGTACAGGTATCCCCACCAGGACAAAGGCCAAGGTCCAATTTCTGTTCAGGGAACCATCTGTGTGTAAACTGATGTTTCATTTTCTTTACTGCAAGGCACTTAAAATTGCAACTCTCATCTTTCACAAACAGACGACCCACGACCACCGAACCCACCCAAACCGATGCCAAATCCAAACCCCAACCACCCTAGTTCCTCCGGTAAGAGTCTCTGACCCTGTGGGATGTCTTCATGTTGTTCAGAATTCAGCGATATTTATGTCAGCTGAGAGGAGGTGATTTCAGATGAGTGTGTGCTTACTGTTGACTGCCTGTGCAGTGTAATGCCCATGTTCATGTAATGGAAAATGTACATTTCAAAAATATATATTTAGCTTGGATTTTATTTTTAGTTTGCTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTTGTTCTGTCACCCAGGCTGGAGTGCAGTGGTGCCATCTTGGCTCACTGCAACCTCCACCTACTGGGTTCAAGTGATTCTCCTGCATCAGCCTCCTGAGTAGCTGGAATTACAGGCACACACTGCCATGCCCGGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGATCCACCCACCTTGGCCTCCCAAAAGTGCTGGGATGACAGGTGTGAGCCACTGTGCCTGGACTAGTTTGCTACTTTTGTTTCCAAGTTCCATCTTATGGAACTTCTAAAAAATTGCATACAATAATTTAAATGTAGACTTGATAAAGAGAAAAGTATTGGCATACACATTCCTTGTGGAGAAGCTAGTGTGTTTTAAATCTTTCTGCCCTTAAATATTTAAGTCAGTTTTTCTGACATATCACAGCATTTTCAGCGTAATTCGAATAGCACCAGTTTTTTTTTTTTAGCTGAATGGTTGTCGAAAGTTTATATGTTTAGGTTTTTTTGTTTACATATTTAATTTTTAACACAGAAGAATATTAATGATGTCCATATCTTGTTGACATTTTGATGGCTATTTGTGCTAGTATTTTATATATCTTTTTTTTTTCTTTTTTGAGACAGGGTCTCACTCTGTTGTCCAGGCTAGAGTACAGTGCTGTGATCATATTAAACATAAGAGCATACCACAGCCTCCAACTCCTGGGCTAGAGAGATCCCCCTGCCTCAGCCTTTCAAGTAGCTGGGGCTACAGGCACACAGCATCGTGACCAGTTAGTTTTTTCATTTTTTGTAGAGGTGGGGTCTCAGTATGTTGCCCAGGCTGGTCTGAAACTCCTGGCCTCAAGCAGTCCTCTTGCCTCAGCATCCCAAATCTCTGAGATTACAGGCACGAGTCACCTCACCCAGCCTATATATTAATCTAAATGAAATAAATTTTAAATAAAGTTCCAAGTCTTTTGTTTGTACTGCATTGTAACATTACTTTTTGCTTACTGATAGTCCATGAACATTTTTTCATGTCATGTAATCATTTCTATCGTATGAGTTTTACTGATAATCATGTACTATTACATACTACATATATAATTATATTCTTCCTGTAACTAATCCCTAATTCTGAAAATGTTATGTTTCTTCTGGCATTTTAGAATTATGAATTAACAAAGCAAATCTGAGTCAACTCCATGCGCTATTTTTATTCCTTTGAAGACATTTCTAGCATTCAAATAGTTTAGATCAACGTATATGAGTACTTTCGTAGCTTTTGACCTGGTTGTTAATTTGCTGCAGATTTTTACCAATTTATTTTGATGCCAGGGGTGTGTGCAAATGTCCCTGTCTTCACACCATCTCCAATATTAGTTATCACCTAGGAAACCTTTGCAAATAGTGTGAAATTTTCTATCAACTTTCTCCTGGTTTCATGACTTTACTTTTAAAATTAAAAAAAAAAAACAAACCTGCATCAATTGGCCGTGGATACTTCTTATTTTGTGTATTGTATGCTTTGCCTTTTATTCTTACATTCTGATATGACATTATTGATTTATAAGCCTTCTTCATTTATTTACAGACATAAATATTGCCAGCATGCAATATTATGCTCACGTTTTTCCACTTTATTTATGGTTTTTTGTTTTGTTTTGTTTTGAGACTGAGTTTAGCTCTTCTTGCCCAGGCTGGAGTGCAGTGGTGCCATCTTGGCTCACTGCAACCTCCACCTCCAGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACATGTGCCTGTCACCACATCCAGCTAATTTTTATATTCTTAGTGGAGATGGGGTTTCACCATGTTGATGAACAGGCCGGTTTTCATGAGTTTTTCCTTTATTCTAAGACATGAAGACCCTTGGAGGAGTTCCAGGTTGACAGGTGATGCTGTATTTTCTTTCCTAGGTAGCTTTTCAGATGCTGACCTTGCGGATGGCGTTTCAGGTGGAGAAGGTACAGTTATCTTGTTTTCTGTCTCTTTTCTCTCTCCATCCCATGATGCCCACCTGCTCTGTAGAATCACTACAGGGTCTAAACTGTCAGCTCTCTGTGAACTCACAGTGAAATGTTCAGCCATCTCTGTGGGAACTCCGCCTGTTTGCTGAGGCTTCAAGGATGTGGGAAGTAAAGGCTGCCCCGTAGAGGTTCGGTCCTCGGAGAAGAGTTCAGGGCCCAGGCAGCTGCCCCACTTTTCTGAGGGACAGGGCGTGATGAATGGGCCCTTGTCACCACCTCCTCACCCATCCGTTCACCTGTGTGTTCTTGCAAATAACTAGTGTTGTTTCAGCTTCATTTTATTAGGCTGTTTTCTGTAATTTAAGGAATGTGAATATTAAAGCCCTGAGAATAGTGATAATGCCTGGGAGTATGCGTTCTCAGAGTACCCCTAGAGTGTAACAGGCAGCACCTCAGCTCTGTAGCTGTGTAACATGCACCCTTAGAGTGTAATAGGCAGGACCCCAGCTCTGTAGCTGGGTAACATGTACCCCCGTAGAGTGTAAGAAGCAGGACCCCAGCCTCTTCACGGTCCTGGCTGTGAATTTTTCCTTGACCCCAAACCTTCCCATTGCAGACGTTGTTTTTGTCTTGCAGGAAAAGGAGGCAGTGATGGTGGAGGCAGCCACAGGAAAGAAGGGGAAGAGGGTAGGTGCACCTGGCTTCTGTCTTCTTGTCTCTCCCACGTGGTGTTGAGAAGGGGAAGCAGAATGTCTGAGAGCTGGCGGACTGCACTGGCATTGGCCTCCTAAAGCTACTGGCAGGAGGCACGGGTGTTCTGTGCCAAGTGCTCCCAAGTGATGTAGCTGCAGAGGTCCCCCAGCAAACCAGCCCTGCTCCGGGTGCCCACGTGACGCGGATTTTATGTTTGGTCACCTGCCCACGATGCCCTGGCTGGCGACCCGACCCCTACATCACGCTTCGCCTTGTCCTTGTGTTTACAAAAGCTCCTACACTCACCCTAACGATCAGAGGCTTGTGACGCAGTATCCTCGGTTGCGCTTGGCCCTTGAGAACGTCAGTAACCAGGTGGGAGGTGGGAATGTGGATCGCTTCCACCCTGGCTGTAACAGGCATTGTGTTCTCCATGGAAGTGCCGGTGATGTATCTCCTGTCTCCTTTTTCATAACCTTTTCCCTTAGATGGGACAAGAAAATAATGACAGACAGAATTCCTTTTAAAACTGTAAAGAAAACAAAATGAGGTAAGAAAGAGAAACAGAGAAGTAGGGAGGAAGAAAAAAGGGAAGGAGGGAAGGAAAGAAGGAAGGAGGGATGGAGAGAAGGAAGGAAGGAGGGAAGAAGGGAAGGAAGGAAGGGAGGAAAAGTGGGTAGTCTACCCTTGTTTTAGGTATTTATTATTTTTATGGGTACAGTTCTTGAATTCTAGGCTTTCTTTGAAGAGGTAGTAATCTGTAGCCCTCACCTAGGACTACAAGGTCATTTTTTAAAAAATAGCTAAGAAAACACATGTCTGGCATGTTTATCTCAGGCCATCGTTCTTGGCCTTCTAGAGAGTTAATGTCTACTATGTCACTTCATCAGGGAGGGGTAGTTAAGCTTGAAAAATCTTTCTATGACATGACTGTGTCCTGCACATATTAAAAACTGGCCGAGTGAACACACCACCGACAGGCCATGTTTGGAGCCAGTGTTTTTGCTGAAAGTCAGACAATTCTCCTTCCCCGTCGTGGAGGGCGGAGAAGATTCTATCTGGAGAAGGGTCCTCTGAAGCTCACATCTGGCATTTGGAATGAATAATCTCTTCAATGGCCAGGCACGCTGGCTCATGCCTGTCATCCCAGAACTCTGGGAGGCTGAGGCGGGAGGATTGCTTGAGGCCAAGAGTTCGAAACCAGCCTGGCCAACATGGTGAAACCCCTTTTCTACAAAAAATACAAAAATTAGGCCAGGTGTGGTGGCTCACACCTGTAATCCTAGCACTTCGGGAGGCCAAGGTGGGTGGATCACTTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAAGATGGTGAAACCCCATCTCTACAAAAAATACAAAAATTAGCTGGGCGTGTGCCATGCACCTGTAGTCCTAGCTACTCGGGAGGCACAAGAATTGCTTGAACCCGGGAAGCAGAGGCTGCAGTGAGCTGAAATCGTGCCACTGCACTCCAGCCTGGGTGACAAAGTAAGACTGCATTTCAAAAAAAAAAAAAAACTAGCCAGGGGTGGTGGCACACACCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATAGCTTGAACCCGGGACGCAGAGGTTGCAGTGAGCCGAGATCGCACCACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCTGTCTCCCCGCCAAAAAAAAAAGAATTATTGCTGGAATAACATAAAAAAAAAAAAAAAGGCTGAGTGTGGTGGCTCATGCGTGTAATCCCAGCATTTTGGGAGGCCTAGGCAGCAGGCAGGTTGCTTTAGGCTGGGAGTTCGAGATCAGACTGGGCAACATAGCAAGACCCCAATTCTATAAAACCACAGTAATTAACCAGGCATGGTGGTGCACACCTGTAGTCCCAGCTACTCGGAAGGCTGAAGTGGGAGGATCTCATGAGCCCAGGAGTTTGAGATTGCAGTGAGCTGTGATTACATCATTGCACTCCAGCCTGTTTGACAGAGCAAGAACCCATCTCAAAATAATACACAATAATAATAATTAATTAAATAGAGATAGATTTAAAATGTCTGCATTGAAACCCAAAGCTATCTTCAAGGGGTGAAAAAGGAGCATTCTAACGATACAAAACGCATTGGCAAATGCCCCAAGCATTGCAGGTCTTTGCTTCTTTATCTTCTGCCCCTGCCTGGGCTCCTTCCTCCAGGTTTGATGTCCAGCTCTCTCTTTCTTTTTTGTTTTGTTTTGTTTTGAGATGGTGAATTGCTCTGTCGCCCAGGCTGGAGTGCAGCGGCACAATCTCGGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGCGATTCTCTGGACTCAGCCTCCTGAGTAGCTGGGATTAAAGGCACCCACCCTTACTCCCGGCTAATTTTTGTATTTTTCGTAGAGACGGGTTTTACCATGTTGACCAGGCTGGTCTCAAACTCCTGACCTCAGGCGATTCACCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCACGCCCAGCCCCAGCTCTCTTTCCATCTGTCTTTGTCTTTTTTTGTCTCTGCCTTGGTTCTGCTGAGCTTCTGCCCGTACCTCGCTGGCCTCTCTTCATGTCTCTTTTCTCCTGCTCCACTCCCTCCATGGTCTGACCAGGTCTGCCCAGCACGTGCGATGGGAGATTGTGCCTTGCTTTGCCTTCCTGTGTATCATTCTCGGCATGCTTCCTTTGCAAATCGGTCAGCTCAGGCGTCTGAGATGTTCTGAGGATCTTGGTGCTCTCAGACTGACTGTCTCTGCCAGCCACTGCCCCCTGGGATCTTCTCTGCACCGTGCGTGTCTCAATCACGATGCTGTGTGCTTCCTCCTGCAGCCGACGCCCCAGGCGTGATCCCCGGGATTGTGGGGGCTGTCGTGGTCGCCGTGGCTGGAGCCATCTCTAGCTTCATTGCTTACCAGAAAAAGAAGCTATGCTTCAAAGAAAATG primary great saphenous vein varicosities 29577902 Identification of aberrant circular RNA expression and its potential clinical value in primary great saphenous vein varicosities. Zhang W, Li L, Si Y, Shi Z, Zhu T, Zhuang S, Fu W. Biochem Biophys Res Commun. 2018 Significantly lower in the PGSVV group than in the control group. RNA-seq, qRT-PCR vein samples of primary great saphenous vein varicosities patients hsa_circ_0091017 circRNA homo sapiens TAF1 hsa_circ_0091017 GTTTTGCAGCCACTCTTGATGATGACAAACCTTGGTACTCCATTTTTCCCATTGACAATGAGGATCTGGTATATGGACGCTGGGAGGACAATATCATTTGGGATGCTCAGGCCATGCCCCGGCTGTTGGAACCTCCTGTTTTGACACTTGATCCCAATGATGAGAACCTCATTTTGGAAATTCCTGATGAGAAGGAAGAGGCCACCTCTAACTCCCCCTCCAAGGAGAGTAAGAAGGAATCATCTCTGAAGAAGAGTCGAATTCTCTTAGGGAAAACAGGAGTCATCAAGGAGGAACCACAGCAGAACATGTCTCAGCCAGAAGTGAAAGATCCATGGAATCTCTCCAATGATGAGTATTATTATCCCAAGCAACAGGGTCTTCGAGGCACCTTTGGAGGGAATATTATCCAGCATTCAATTCCTGCTGTGGAATTACGGCAGCCCTTCTTTCCCACCCACATGGGGCCCATCAAACTCCGGCAGTTCCATCGCCCACCTCTGAAAAAGTACTCATTTGGTGCACTTTCTCAGCCAGGTCCCCACTCAGTCCAACCTTTGCTAAAGCACATCAAAAAAAAGGCCAAGATGAGAGAACAAGAGAGGCAAGCTTCAGGTGGTGGAGAGATGTTTTTTATGCGCACACCTCAGGACCTCACAGGCAAAGATGGTGATCTTATTCTTGCAGAATATAGTGAGGAAAATGGACCCTTAATGATGCAGGTTGGCATGGCAACCAAGATAAAGAACTATTATAAACGGAAACCTGGAAAAGATCCTGGAGCACCAGATTGTAAATATGGGGAAACTGTTTACTGCCATACATCTCCTTTCCTGGGTTCTCTCCATCCTGGCCAATTGCTGCAAGCATTTGAGAACAACCTTTTTCGTGCTCCAATTTATCTTCATAAGATGCCAGAAACTGATTTCTTGATCATTCGGACAAGACAGGGTTACTATATTCGGGAATTAGTGGATATTTTTGTGGTTGGCCAGCAGTGTCCCTTGTTTGAAGTTCCTGGGCCTAACTCCAAAAGGGCCAATACGCATATTCGAGACTTTCTACAG bladder cancer 29151929 Identification of circular RNA signature in bladder cancer. Yang X, Yuan W, Tao J, Li P, Yang C, Deng X, Zhang X, Tang J, Han J, Wang J, Li P, Lu Q, Gu M. J Cancer. 2017 The level of hsa_circ_0091017 in cancerous tissues were significantly reduced compared with noncancerous tissues RNA-seq, qRT-PCR bladder cancer and adjacent non-tumour tissue circVMA21 circRNA homo sapiens VMA21 hsa_circ_0091702 GCGCCCTTGGGATGTCCAATAGGGACAGCTATTTTTACGCTGCTATTGTTGCAGTGGTCGCCGTCCATGTGGTGCTGGCCCTCTTTGTGTATGTGGCCTGGAATGAAGGCTCACGACAGTGGCGTGAAGGCAAACAGGATTAAAGTGAACATCACCTTTTTATAGCATTAAATTCATTTTTTAAAATGATAAATGCTGGAGGGGGCCATCTGATTTGAATAAAGTTGAAAGAACATGTTAAAGTCAGTCTTAAGGAGTCACGTTTGAGTATGTAAATTTTGATCTTTCTAATATGTTGGTTTGTATATTCAGTTTTAACTGTATGAATCTGATTTGCAAATGAGAATTTGGAAAAGTTAGTTACAAAGAAATATGTTAATTTAATTAGACAATACTCTGGAAGGAATTTTATCTTCTTTCAACAAAACATGTTTTATAGTATTCTGACTTACGGTTGCTTTTGAGTTTTACTCATTTGGATATATTAAGATGCACACAGTGAAGCAAATTAAACTCCACTTTACGCTGGAATGCTTTCTTTAGCATGAAAATACCAGGTCCTTGGATTTGGGATTTTAATTTCCTATGGAAAGTTGCTTAAATTGTGGACACTGGAATTAATCTGAATGTCACTGAGGAATTTCACATGAAGTGTAATCCCTAGTCAATAAGAATTATCCATTACATTATTTTATGGGAAAACTAGGCTAAATTACATCCATTCAGGTAAAAGGACCTTAGCTTACTGAAGGATCTAAAGAGCAAAGCAAAGATCTCACTACTCAAACACTCAGCCTGCTTCCTTCAAGTCCCCTTGCAGGCCAGCTTTGTGCTTTGCAGACCAACTTTTTAATGAGATACTTTGCTTCCTCATTCAACATTGAAGCTAGGCTTCAATTAAAAGGTTCGAGGAAGCTCCATTTAAAATTGTTTTTTTTACTATTTTTTAAAATTGTAGTGTATATGATAGGAATTTGCATTTAAATATGTTCATTTTTGCATATGTTAGGAGTGGAAACAATCTGGAAAACATTTTTTTTTCATCCAAAAAGTATTCTCCTTGGGCATATCTGATGGAAAAAAACCTTGATTTTATTTTCGTATCTTTAGTCTGTGTTCTTTCTAGTTATTTGGTACTAATTATGTGCAATCTAAAAACACTCCCACAAGTATTTGTTTTTTAATTATAAAATCATAGTATATGTTCTTTGTAGAAAACTGGAAAAATACATATTCAAACAGGAAAAAAAATCAAAATTCCCCATAATGTTGCCATCTAAAAATAACCTCTATTTTAGTTGATATCCCGTATTCATTTTTGAAAGCCATTCCTTAATGCTAGTTTGATACACACTAAAAGTTTAGCTTACAAGTTCAAATTCTGCCAGCTTTTCCTGACAGCTATTTGCATTTTTTTCAGATGAGTGATTATTGGCCATTTTCTTTTTCTTTTTCTTTATTTTATTTATTTATTTTTTTGAGACAGAGTTTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGTGCAATCTCGGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGTGATTCTCCACCTCAGCCTCCCAAGTAGCTGGGACTACGGATGCCTGCCACCACGCCTGGCTAATTTTTTTTTGTATTTTTTTGTAGAGACGGGGTTTCACCATGTTGTCCAGGCTAATCTTGAACTTGTGACCTCAGGTGATCCACCCGCCTCGGCCTCCGAAAGTGCTGGGATTACAGGCGTGAGCTACCACGCCCGGCCTTATTGACCATTTTCTAAATAAGCACATTCTATCTTTATTCTCTTAAAATTCAAATTTTCTGTTACTGATAATCCTAATACTAGGATTCTTGCTTAAGTATGTGAAACCATTACCGATTTGTTGTTCACATTTATTTTTTATGTTGTGAAACTGGACTAAAGGAATAGAGGGATGATTAGTCATAAAAGTCAAATAGCATTTGTGTTTAACTGTTGAGAAAAGTGAAAGATCAGTATGATTATTATGGAACTGTTTTTAATTCTTGCTTAAAGACTACAATTTTAGTATAATGACATTTGAGTCTAGGGTAGTATGTGGTAGATTTCTAGATGGTCCCTAATTAAGAAGTATTGTTGTATTTAGAATTGTCCACCTAATTTCTTTTTATATAATGCCAAGGTATTTCTTGTGCTTTTGGGATCTTATGCTGTTTGTAAAATGTTACTGTCCAATGTTGGATTATTGTTTTGGTTTCAGGCATTTGCTGAATAGGTGATGATACATGGGTATTTTTCTGCAAGTATTTAAACCAGGGGCATATGCAAAGGCAGTTGTAATTTCCTCTTGGAAAAAGCGCCAAATGTTTGAAGGTTAAAATCAAATGCTAGGGTTGATATTTAGGCTTATAACAAAATAGGCTTGTTTTCAAAGCAGTTTTTTCCTAGAGTTTTAACTGTTAACTCACTAGTTTGCTGCTGTTTTTAACTATGTTAAATAACATATGGTATTTGGCAAATAGATTTATTTTTCAAAATGTCTCACTAGTTTCCTTTTACACAATGTATATACTTCAAGATGTATAGAAAGGAAAGCTACAGTTGAGCCCTTATACATGTTTTAAGGTAGAAATATGTTCCCTATTGTTTGAAAACTGATTGTAAGAATAACCTCAGTTAGGAGATATAACTTGAAGTGTCAGTCCAAACTACTGATTTAACCCTATTTACGGTAACACATTACCTTCCTCACCTCCTGTTTGGCCCTGGAGAATGTAGTCCTTTTTCTCATTTGTGTTGAGAAATGAAAAGTCTGCTGTAGAATGTATCTGATGTCATTAGTTCTTCAAATGGATACCATTGTACATATAACAGTAGAATTTGGTTTGGGGTTGTTAGTGAAAAAAAATTTAAACCTGCCATTAAAAATCCCCATGTTTCATGGAAATCTAACAGAAATACATTGTAATAATTAGAACATTTTGTTTTCTTTTTTCTTTTTTTTTTTTTCGAGACGGAGTTTTGCCCTTCTTGCCCAGGCTGGAGTGCAAGGGCGCAATCTCGGCTCGCTGCAACCTCCGCCTCCCGGGTTCAAGCAGTTCTCCTGCCTCAGCCCCCTGAGTACCTCAGATGACAGGTGCGTGCCACCACACCCGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTAGCCAGGCTAGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCCTCCGCCTCCCAAAGTGCTGGGATTACAGGTATCAGCCACCGTGCCTGGCCTAATAATTGGAACATTTTCATCATGAAAATGTCATCAGCTTTGCCAAAAGAAACAACCAATTGACTTGTTTGGCGTTTGTTTTCCATTTTCATGTCAATTTTATGTATACAGTTAGAATACCCAAGGAGACCACTAAAATCAGTTAAACAAGTAGGGTATATACAAAGAAAGATGAAACCCGAAAGTACATAAAAAGGATTTAAATCCGATTTTAGATGTACCTAGTGTGTATTTCTTATCTCTAGACAAGTTCATGTTTATTGTTTAATTTATGCCCAAGTGAAGTTGTAAACTTATGGTTCAACTCTGACACAGAATTTGTCACTTGTCTGAGGTCAGTGGCAGGTTTCTCTGCTGTCAAGCACTCTGTGTCACCCACCAGATTAGTATAACTATTAATTCAGACTGTACTCCTATGTTTAAGATAATTTTTACAAGAGCTGGCTGAAGCAGCACATTAGTAACCTGACAAGATTTCTTTTTCCCTTTTCAGGGGGAAAGGGTCACCTTAAAAATAAATTATTTTCAGGGACTTTGGGAATCTAATGATAAATATTACACATAATCTATGAATAGCTTAATCCTTTATATATTCCTTAAAATAGGAATTCCTCGACATCACTCCTGGCCACACTTTCCTTGCCTGTGTTGTTGCTATGTGTATTTGAAAGTAATATCTGCATTCCTTTTAAGATGTTCTGTAAGTCATATTTGTCAGTTATACAGAGTAGTCTTCCTTTTCCCCACGTTCAGTGTAATCTCACTGAACAGTAATAATAGCAATAGCTAACAACATCTGCACAGCACCTTACAGTTTGCAAAGAACGTTCACACATTCTCATTTGAGTTTTGCATAGTGAACCTGTTACGAGATGTCTCTTGACGTCGATGCTAAAAGTGTTAGAATCTTTACATCACTAGAGTCATTGAATATGCTGTAGTATTGAATAGTGCCCTGACTAGGGGGAGGATTTGGATGTGCTGCATTTCAAGCCGTGTATAATCATCAAAATGGGGGGCTTGAGTTCTTTAGCTACTTGAATCCGATTTACTTCTGTTAAGTGATGCTTTTCTAACCGTTTTCTGGATGGATTTTGTATTCACTATATTGTAGCTTGTAATTTGTATAAATGTACCATCTGATGTCATTAAAAAAAGTGTTTGTAGTGCTA intervertebral disc degeneration 29343508 Circular RNA VMA21 protects against intervertebral disc degeneration through targeting miR-200c and X linked inhibitor-of-apoptosis protein. Cheng X, Zhang L, Zhang K, Zhang G, Hu Y, Sun X, Zhao C, Li H, Li YM, Zhao J. Ann Rheum Dis. 2018 CircVMA21 levels were markedly reduced in the degenerative NP tissues compared with the controls by qRT-PCR analysis. This result was also confirmed by RNA fluorescence in situ hybridisation (FISH). qRT-PCR,FISH rat nucleus pulposus tissue CircVMA21 acted as a sponge of miR-200c and functioned in NP cells through targeting miR-200c and XIAP. Intradiscal injection of circVMA21 alleviated IVDD in the rat model. CircVMA21 could alleviate inflammatory cytokines-induced NP cell apoptosis and imbalance between anabolism and catabolism of extracellular matrix through miR-200c-XIAP pathway. It provides a potentially effective therapeutic strategy for IVDD. loss of function nucleus pulposus cells, rat nucleus pulposus tissue IVDs of rat models miR-200c circRNA-miRNA nucleus pulposus cell luciferase report assay, RNA pull-down assay, FISH circVMA21 was able to directly bind to miR-200c in NPCs XIAP hsa_circ_0091742 circRNA homo sapiens BGN hsa_circ_0091742 GTCTGAAGTCTGTGCCCAAAGAGATCTCCCCTGACACCACGCTGCTGGACCTGCAGAACAACGACATCTCCGAGCTCCGCAAGGATGACTTCAAGGGTCTCCAGCACCTCTACGCCCTCGTCCTGGTGAACAACAAGATCTCCAAGATCCATGAGAAGGCCTTCAGCCCACTGCGGAAGCTGCAGAAGCTCTACATCTCCAAGAACCACCTGGTGGAGATCCCGCCCAACCTACCCAGCTCCCTGGTGGAGCTCCGCATCCACGACAACCGCATCCGCAAGGTGCCCAAGGGAGTGTTCAGCGGGCTCCGGAACATGAACTGCATCGAGATGGGCGGGAACCCACTGGAGAACAGTGGCTTTGAACCTGGAGCCTTCGATGGCCTGAAGCTCAACTACCTGCGCATCTCAGAGGCCAAGCTGACTGGCATCCCCAAAGACCTCCCTGAGACCCTGAATGAACTCCACCTAGACCACAACAAAATCCAGGCCATCGAACTGGAGGACCTGCTTCGCTACTCCAAGCTGTACAGGCTGGGCCTAGGCCACAACCAGATCAGGATGATCGAGAACGGGAGCCTGAGCTTCCTGCCCACCCTCCGGGAGCTCCACTTGGACAACAACAAGTTGGCCAGGGTGCCCTCAGGGCTCCCAGACCTCAAGCTCCTCCAGGTGGTCTATCTGCACTCCAACAACATCACCAAAGTGGGTGTCAACGACTTCTGTCCCATGGGCTTCGGGGTGAAGCGGGCCTACTACAACGGCATCAGCCTCTTCAACAACCCCGTGCCCTACTGGGAGGTGCAGCCGGCCACTTTCCGCTGCGTCACTGACCGCCTGGCCATCCAGTTTGGCAACTACAAAAAGTAGAGGCAGCTGCAGCCACCGCGGGGCCTCAGTGGGGGTCTCTGGGGAACACAGCCAGACATCCTGATGGGGAGGCAGAGCCAGGAAGCTAAGCCAGGGCCCAGCTGCGTCCAACCCAGCCCCCCACCTCGGGTCCCTGACCCCAGCTCGATGCCCCATCACCGCCTCTCCCTGGCTCCCAAGGGTGCAGGTGGGCGCAAGGCCCGGCCCCCATCACATGTTCCCTTGGCCTCAGAGCTGCCCCTGCTCTCCCACCACAGCCACCCAGAGGCACCCCATGAAGCTTTTTTCTCGTTCACTCCCAAACCCAAGTGTCCAAGGCTCCAGTCCTAGGAGAACAGTCCCTGGGTCAGCAGCCAGGAGGCGGTCCATAAGAATGGGGACAGTGGGCTCTGCCAGGGCTGCCGCACCTGTCCAGACACACATGTTCTGTTCCTCCTCCTCATGCATTTCCAGCCTTTCAACCCTCCCCGACTCTGCGGCTCCCCTCAGCCCCCTTGCAAGTTCATGGCCTGTCCCTCCCAGACCCCTGCTCCACTGGCCCTTCGACCAGTCCTCCCTTCTGTTCTCTCTTTCCCCGTCCTTCCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTTTCTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTCTTGTGCTTCCTCAGACCTTTCTCGCTTCTGAGCTTGGTGGCCTGTTCCCTCCATCTCTCCGAACCTGGCTTCGCCTGTCCCTTTCACTCCACACCCTCTGGCCTTCTGCCTTGAGCTGGGACTGCTTTCTGTCTGTCCGGCCTGCACCCAGCCCCTGCCCACAAAACCCCAGGGACAGCAGTCTCCCCAGCCTGCCCTGCTCAGGCCTTGCCCCCAAACCTGTACTGTCCCGGAGGAGGTTGGGAGGTGGAGGCCCAGCATCCCGCGCAGATGACACCATCAACCGCCAGAGTCCCAGACACCGGTTTTCCTAGAAGCCCCTCACCCCCACTGGCCCACTGGTGGCTAGGTCTCCCCTTATCCTTCTGGTCCAGCGCAAGGAGGGGCTGCTTCTGAGGTCGGTGGCTGTCTTTCCATTAAAGAAACACCGTGCAACGTG gastric cancer 28639908 Circular RNAs play an important role in late-stage gastric cancer: Circular RNA expression profiles and bioinformatics analyses. Fang Y, Ma M, Wang J, Liu X, Wang Y. Tumour Biol. 2017 upregulated in GC microarray, qRT-PCR III stage gastric cancer and paired paracarcinoma tissue hsa_circRNA_105038 circRNA homo sapiens FLNA hsa_circ_0091894 GCTATGGTGGGCTCAGCCTGTCCATTGAGGGCCCCAGCAAGGTGGACATCAACACAGAGGACCTGGAGGACGGGACGTGCAGGGTCACCTACTGCCCCACAGAGCCAGGCAACTACATCATCAACATCAAGTTTGCCGACCAGCACGTGCCTG papillary thyroid carcinoma 28288173 Microarray profiling of circular RNAs in human papillary thyroid carcinoma. Peng N, Shi L, Zhang Q, Hu Y, Wang N, Ye H. PLoS One. 2017 upregulated microarray, qRT-PCR PTC tumors, matching contralateral normal samples, benign thyroid lesions (i.e., follicular adenoma samples and multinodular goiter samples) hsa-miR-134-3p, hsa-miR-149-5p, hsa-miR-504-5p, hsa-miR-339-5p, hsa-miR-329-5p circRNA-miRNA predicted hsa_circ_0092276 circRNA homo sapiens NISCH hsa_circ_0092276 GTAGGCACAGGGCCTGCTGGGGCTCAGGAGCTTGGAGTGTGTGGTTGGGGCAGGCCTGGGGGGTCATTCTCTGGAGCCAGCTGTGTGGCTTCAGGCAGCAGTCAGCGACTTGGCTGCAGTGGGCTGAGAGTTCCTTGTCTGAGGAAGGGAGCTGTCATGAGGGAGGGGTCCATGGCCAGATGTGAACGCAGAATGCACTGAGCCAGGGCCTGGTGACTGCTTGGGAACAGCCAGTGATGAGAAGGGGTTAGGCAGCCTTTGCCCCTGGGGCTGCACAGGAAGCCCTAGCCAGCGACCTGGTGACTCCCCTGAGCTGGAAGAGGCTCCGACTCCAGAGGGCATTGCCTATGGGGCTTTGCACGGGTGGAAGCCAGGCCAGCCAAGAGGACCTGTTCCTGCTGGATGTGCTGCACACCTAGGAACCTTGTGCTTGCCTGCCA breast cancer 28803498 Screening circular RNA related to chemotherapeutic resistance in breast cancer. Gao D, Zhang X, Liu B, Meng D, Fang K, Guo Z, Li L. Epigenomics. 2017 up microarray, qRT-PCR MCF-7, ADM-resistant cell lines (MCF-7/ADM) hsa_circRNA_400064 circRNA homo sapiens PWP2 hsa_circ_0092315 CCACGCCCCATCGGGGCAGAAGCCCACTGTCCCCTAAATGTTTCTGGGGGAAAGTGTCCTTGGCATTTTCACAAGGGAGTAGACGGCCATCCTCGCTGTGAGCCCCAGCCTTTGTGATGGTGGCAGCAATGCCAGCATGTAGACCTCAGTCCATCCCCCTCCGCAGCCTCCGCACCTGCCCTGCTCCACAGCTTCCACAC papillary thyroid carcinoma 28288173 Microarray profiling of circular RNAs in human papillary thyroid carcinoma. Peng N, Shi L, Zhang Q, Hu Y, Wang N, Ye H. PLoS One. 2017 upregulated microarray, qRT-PCR PTC tumors, matching contralateral normal samples, benign thyroid lesions (i.e., follicular adenoma samples and multinodular goiter samples) hsa-miR-658, hsa-miR-494-3p, hsa-miR-675-5p, hsa-miR-604, hsa-miR-361-3p circRNA-miRNA predicted hsa_circ_0092337 circRNA homo sapiens RPL13 hsa_circ_0092337 CCGTCCTGGTGCGCGGGGACAGTGAGGCTTGGCTCCTTTATCAGTGACACCGGTCCCTGGGTCTTGCTGGGGTGAGAAGAACCAAAACATTGTGGGTGATGAGCTAAGCGGGACTGCTAAGGTTCACCTGTGCGTTTCCGCAGAGATAACCTTAATGGACATGGCAAGGCTGTGTGACTTGGAGGCAGCTTTTTCCATTGACGTTGCTCTCCCTAAAATGCTTCGTATTCCAAAATATTTCTAGAAAGACCTTGTAGGATAAGGTTGATAAAGAGTCCATTGTATACGTTTCCGGGTAGTTAAATTAGGGAACAGTTTTCTCTGCCCCGCCCGTGGTTCACAGGTAGATAACTGTCTCGT osteosarcoma 29229385 Circular RNA hsa_circ_0001564 regulates osteosarcoma proliferation and apoptosis by acting miRNA sponge. Song YZ, Li JF. Biochem Biophys Res Commun. 2018 upregulated microarray, qRT-PCR OS tissues and adjacent non-tumor tissues, NHOst, MG63, Saos-2, HOS, and U2OS hsa_circ_0092341 circRNA homo sapiens C6orf132 hsa_circ_0092341 GCTGCGGGCCCGGCTGGTGCGGGAAGCCAGGAGGGGTGGAAAGCCAGGCGAGGGCCAAGGAGTCCCGGCCATCCGTCAAGAGAAAACATTTGGTTTTCTCCCTTCGGCCTTGCAGGTAGAACGCGGGAGGGAGGCCCACTTACCGGGAGAGGGCGCTGTTGGCGCCTTCCTGACCTCCCTCCTGACCTCCCTTCTCTTTC gastric cancer 28737829 Expression profile of circular RNAs in human gastric cancer tissues. Huang YS, Jie N, Zou KJ, Weng Y. Mol Med Rep. 2017 downregulated microarray, qRT-PCR GC tissues and adjacent normal tissues hsa_circ_0092348 circRNA homo sapiens LARP7 hsa_circ_0092348 GTAAGTCTGTGGTTTAAATTCTGTCATTGGCTTAACAATCCATCACCATTGCTAAAGTGCAATTCCAATTTATATTCAACAGAGTTGCATATTAGCAACAGTAATGGCCTGTAGCCAAGAACTGCACACAGTGTGGGCGTTAACGCAATTGCTGATTAGGTAGGAACCACCACACTCAAACATGGAAGCACTTATTTTTGTCATGTCACAGCAAGTGCCTCCATGTTAAAGTAGAGGGGGCCCCTTAACAGATGTAAAAATACAAAATAAAGCTTAAATATATGAGCTGCGGTCAATACAATAAAGTTATTTTCTAAAAAAATAATAAAAATGTAAAAGGAAGACTTACCATCACCAAAACATGGAAGCACTTACTTCTTTAGTTTCAAAGCAAGTACATCCACGTTTAAGTGGTGGGGAGCCCAGTCTTGGAAAAAGTTAGAATCCTTTAACCTGTAACAAGCTTAGTAACCTTAAAACACAATAACAAAAAAATTTTGTAACAAAAGGTGTGCTGGCTTGGAGACACCTCCACTGAAACATGGAAGCACTTACTTTTGTTTCACACAGCAGGTACCCCCATGTTAAAGCAAAGGGGATCCCTTCAAATGAGGTTAGCGTGTTCTATTTTGGAGAAGTAAATTGGATTCACTCCTACTAAAACATGGAAGCACTTACTTTTAAAGTCACAGAAAGCACTTCCATGTTAAAGTTGAAGGGAGCCCACCCAACATACAACTTCTTTGGACTTCAGAGTATTTAGAGCTGAGGAGAAAGAAAACAAAATGGCATAACTTTAGAAGAAAAAAATTTTTTTACCTTCCTGAACTAGTTCCCAAA osteosarcoma 29229385 Circular RNA hsa_circ_0001564 regulates osteosarcoma proliferation and apoptosis by acting miRNA sponge. Song YZ, Li JF. Biochem Biophys Res Commun. 2018 upregulated microarray, qRT-PCR OS tissues and adjacent non-tumor tissues, NHOst, MG63, Saos-2, HOS, and U2OS hsa_circ_0093859 circRNA homo sapiens JMJD1C hsa_circ_0093859 AATTCTCCCAGTCCTTGGCTACATCAGCCCACCCCTGTGACCTCAGCAGATGGTATTGGATTACTTAGTCACATTCCTGTCAGACCTTCCAGTGCAGAGCCTCATCGGCCTCTTAAAATTACAGCCCATTCCAGTCCACCATTGACAAAAACTTTAGTAGATCATCATAAGGAAGAATTAGAAAGAAAAGCTTTTATGGAACCATTACGGTCTGTTGCATCCACATCAGCCAAAAATGACCTGGATCTAAATAGGTCACAGACTGGAAAAGATTGTCACTTACATAGGCATTTTGTGGATCCAGTATTAAATCAGTTACAGAGGCCACCCCAGGAGACTGGAGAGAGGTTAAACAAATACAAAGAGGAACACCGTCGAATTCTTCAAGAAAGTATTGATGTTGCTCCCTTTACAACTAAAATCAAGGGACTTGAGGGTGAGAGAGAGAATTATTCCAGAGTGGCATCATCATCTTCCAGTCCTAAAAGCCATATCATCAAACAAGATATGGATGTAGAACGCTCAGTATCAGATCTTTATAAAATGAAGCACTCAGTGCCTCAGAGTTTACCCCAAAGTAACTATTTCACTACATTGTCTAATAGTGTGGTCAATGAACCACCAAGATCATACCCATCCAAAGAAGTTTCAAATATTTACGGTGATAAACAGAGTAATGCCCTTGCAGCGGCAGCAGCTAATCCTCAAACTCTGACTTCATTTATAACATCTCTTTCAAAGCCTCCACCTTTGATTAAACACCAACCAGAAAGTGAAGGTTTAGTAGGCAAGATACCAGAACATCTTCCACATCAGATTGCATCTCACTCAGTAACAACCTTCAGAAATGATTGTAGGAGTCCTACCCATTTGACAGTTTCTTCTACAAATACACTCCGCAGTATGCCTGCATTACATAGAGCACCAGTATTTCACCCACCAATCCATCACAGCCTGGAAAGAAAGGAAGGCAGCTATAGTAGTCTTTCCCCTCCAACTTTAACTCCGGTGATGCCAGTAAATGCTGGTGGTAAAGTTCAAGAATCACAGAAGCCTCCAACTCTAATACCCGAACCAAAAGACTCCCAGGCAAATTTTAAGAGTTCTTCAGAACAGAGTTTGACGGAGATGTGGAGACCTAATAATAACCTCAGCAAAGAGAAAACTGAATGGCATGTGGAGAAAAGCAGCGGAAAGTTACAGGCTGCTATGGCATCTGTCATTGTGCGTCCATCTTCTAGTACAAAAACTGATAGTATGCCAGCAATGCAGTTAGCTTCTAAAGATCGTGTTAGTGAAAGATCTTCAGCTGGGGCACATAAAACAGATTGCCTCAAACTAGCAGAAGCCGGAGAAACTGGAAGAATCATTTTGCCAAATGTGAATTCAGACAGTGTTCACACAAAATCTGAAAAAAACTTTCAGGCTGTCTCACAGGGCAGTGTTCCCAGTTCAGTCATGTCTGCTGTAAATACGATGTGTAATACCAAAACGGATGTAATCACATCTGCTGCCGATACTACCAGTGTTTCCAGCTGGGGTGGTTCAGAAGTAATTTCCTCTTTATCAAATACCATTTTGGCCTCTACATCATCAGAATGTGTATCTTCAAAAAGTGTCAGTCAGCCAGTGGCTCAAAAACAAGAATGCAAGGTCAGCACCACAGCACCAGTTACATTAGCCAGTAGTAAGACAGGAAGTGTTGTTCAACCCAGTTCTGGGTTCTCAGGCACAACTGATTTTATCCATTTAAAAAAGCACAAGGCAGCATTGGCTGCAGCTCAGTATAAAAGTAGTAATGCCAGTGAGACTGAACCTAATGCTATAAAAAATCAGACACTTTCAGCCTCCCTTCCTCTGGATAGCACTGTAATCTGTAGTACAATTAACAAAGCAAACTCTGTAGGAAATGGGCAAGCTTCCCAGACAAGTCAACCAAACTACCATACTAAACTGAAAAAGGCCTGGCTCACCAGACACTCAGAAGAAGATAAAAATACTAATAAAATGGAAAATTCAGGGAATTCTGTATCAGAAATTATTAAGCCATGTTCTGTCAACTTAATAGCCTCTACATCTAGTGATATACAAAATAGTGTAGATAGTAAGATCATAGTTGATAAATATGTAAAAGATGATAAAGTCAACAGGAGAAAAGCCAAAAGAACTTATGAATCTGGCTCTGAAAGTGGAGACTCAGATGAAAGTGAAAGCAAGTCAGAGCAAAGGACTAAAAGACAACCTAAGCCAACTTACAAAAAGAAGCAAAATGATTTGCAAAAGAGAAAAGGTGAAATAGAAGAAGATTTGAAACCCAATGGAGTTCTCAGCAGGAGTGCCAAAGAAAGAAGTAAACTGAAGTTGCAAAGCAACAGTAATA breast cancer 29593432 Downregulation of hsa_circ_0011946 suppresses the migration and invasion of the breast cancer cell line MCF-7 by targeting RFC3. Zhou J, Zhang WW, Peng F, Sun JY, He ZY, Wu SG. Cancer Manag Res. 2018 up-regulated in both cells and breast cancer tissues RNA-seq, qRT-PCR breast cancer and corresponding adjacent non-cancerous tissues, HS-578T, T47D, MCF-7, BT549, MDA-MB-231, and SKBR-4 hsa_circ_0098110 circRNA homo sapiens AEBP2 hsa_circ_0098110 CATAAGCAGTACTATAATGGATGTAGACAGCACAATTTCCAGTGGGCGTTCAACTCCAGCAATGATGAATGGACAAGGAAGCACTACTTCTTCAAGCAAAAATATTGCCTATAATTGTTGTTGGGACCAGTGCCAGGCTTGCTTCAACTCTAGCCCAGATCTGGCAGATCACATCCGTTCCATACATGTAGATGGTCAGCGAGGAGGGGTTGGTTTTGTCATTTCTTTTTTTCGCTCCCTGTTTTCGTTAGTTTTATTAATTTATAATTGCTAGTTAGGCTTTTTTGCTGAAAGTAATTTGGGATTATTTTTACACAGGCTTAGTTTTTTCAAGTGAATTTTTAATAATTATTTCCCATATACTTGATAGAATCAAATAAAAATAGGGTATGTGCTGGATTTTAGTTTGTTTTTAGATACGTTATTTTGAAGAAATTAGACTTTTAAAAGTATAGTAGGTGACAGTATTATTAATGAATACAGTGTATTCCAGGGTTCTGATGTTTTGAGTTGAGAACATTTAGAATTAGCACTTTCTTGATTTTCCTTTGTTAGAGGATCCTAAATTATTCCTGACGCTTAAATTAACTGGGGAGACTATTGGTACCAGGATTAGTGTATGCAATTCTATTAAATAACAACCTGAACTCATTATTTGTGAGTGAGAATTGATCATCTTTCCCAGGTCTTGTCAGAGCTGATTTAGATGGAAAGTTCTGATTAGTTAGTATTGACCTATATGTCCTTTCAGGAATACATTTAATTGTGTCAGTTCATGTAACTTCTATTAGGTACTGAATAAAGAGCTAAGCAAATTGGGTAAGCCAAAAGTAATGTGCCAAAATATTAATTTATACATTGTTTCAACTTTACCTAGAATTTTGTTGAATAGTTATCACACTTAGTGCATTTTTCAGAAATTAATGTCACAGTGTAAGGGCAGGTAATTTATTAATATTAGGCCACACATTTCCTATCAGCCTGGCATCACTATTGAAGAACAGATAACTAACACAGTAAAAATCATCATGGTTTAAGTTAGTGGGTAACTGTTTCCAAGGTTCTGTTGATATTTAGAGTATAGTATTGATCTTTTTTTTTTAAACATCCAACCGGGTCAACGTTTCTAACATTTTAAGCAGTGATGTCATACTTGAATTTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGCGTGATCTCAGCTCACCGCAGCCTCTGCCCCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGTGCCCGCCACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGATGAGGTTTTGCCATGTTGGCCAGGCTGGTCTCGAACTCCTGAACTCAGTTGATCCGCCCACCTCGGCCTCCCAGAGTGCTGGGATTACAGGCGTGAGTCACCGTGTGTGACCGAAATTTCTTTTAAGACATATTCATCCCTGTCACAATATATTATAATGTGTCAGCAGTTTTTTGATTACTCAAACTTGATAAGTATAGCAATTGTACATTTGTCTTCTTGTTAGAGTTAATATGTATGATGTCTGAGTAACCAGTAAAATGTTATACTTACCTATGATCTGTTAACTAACTGTGTCCATCATATGGTATTTTCAGTGTAAAACCCAGCTCAGTGGTTGGGCTACTTTGGTAACCCAGTCTTCTCCCCCAAGCCATATGTCAGATACTTAGTGTGAAGTATCTTAGCAAGTTGGTTTTCTGGCTTTTGTAGATCTGCTTTTTGTGAGCCAGTGCTTGATGTCACTTGGTATATACCATTTTTGAGCATCATGGCATGATGCTTTTTTGTCACTTGACTTAGCAACTGTGTATAGAATCATGAGCTATTTGGAAGATCACTGGGCTTCTCTTAGTAGATGTGGGAGAGGGAGAATTTCACATTTCTGAGTCTTGGAATCCCACAAGTTGAGCTGGCATACAACCTGATGAGAATTTCAGCCCTTCCCAGATTTGTAGAAAAAATGCAGTTACAGTCTGATTTTTATTTTATTTTTATTTTTTTAAAATTAATTAATTAATTTTTTTTTTTGAGACAGAGTTTGGTTCTTGTTGCCCAGGCTGGAGGGTAATGGTGCGGTCTCAGCTCACTGCAACCTCTGCCTCCCGGGTTCAGGTGATTCTCCTGCCTCACCCTCCCGAGTAGCTGGGATTACAGGCCTGAGCCACCATGCCTGGCTAAATTTTTTTGTATTTTTGGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCCTCGGCCTCCCAAAGTGCTAGGATTACAAGTGTGAGCCATCGCACCCGGCCAAGACTGGTTTTTAAAATAATTAAATATGTCATGTAATCACAGTAATTATATACCTGTACCTTATTGATATTATAGAATTAGACATGAAATGTTGGCATTTGTCCCGTAAGTGTAATATTGAAATGAAAAATCTCCCATGTGATTTCTTGAACCCTTATTCAAAAATATCACTTGATTACCAATAATAAGATTCTCTAGCTGATTTTAAGAGTGATGCTGTTTGGCCGGGCGCGGTGGCTCGTGCCTATAATCCCAGCACTTTGGGAGGCTGAGGCGCGCGGATCACGGGGTCAGGAGTTTGAGACCAGCCTGGCCAATATGGTGAAACCCCGTCTCTACTAAAAAATACAAAAATTAGCTGGGTATAGTTGCGTCCCCCTGTAGTCCCAGCTACTCAGGAGGCTGAGACAGAAGAACCGCTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCTGAGATCACGCCACTGCACTCCAGCCTGGGTGACAGAATGAGACTCTGTCTCAAAAAAAAAATAAATAAAATAAAAAGAGTAATGTTATTTTGATCAAAGATAGGAGTCCTGATCTTTGAAGGACATTATTTGCTAAACTATAAATGTAAAGGATCAAATAATGTAGGAAATGCATCCCAGTTTTTTCCTACATACCAGTCATTAGAATATAGACTATGGTTTGTTTGTTTGTAGAGATGAGGTTTCACCATGTTGCCCAGGCTGGTCTCCAACTCCTCGACTCAAGCGATCTGCCCGCCTTGGCCTCTGAAAATGCTGAGATTACAATAGACTATGTGTTTTGAATGATAAAATATGAATGAGAGTTTGGAAACTTAGTACTACTATAAAAGACAAGAAAACTTGATCTGATTTTGTGCTTTGAGATTGGCTTTTGTGATTGTTTTTTCTTTTTTTTTTTTTTTTTTGAGATGGAGTGTTGCTCTGTTTCCCGGGCTGGAGTGCAGTGGCACGACCTCAGCTCACTACAGCCTCCGTCTCCTGGGTTCAAGCAATTCTGCTGCCTCAGCATCTTGAGTAGCTGGGATTACAAGTGTGCACCACCACGCCCAGCCAATTTTTGTATTTTTAGTATAGATGGGATTTCACCATATTGGACAGGCTGGTCTCGAACTCCTGATCTCAGGAGTTCCTGAGGAGGACTTGATCATCCTCCTCAGCCTCCCAAGGTGCTGGGATTACAGGCCTCTGAGCCACCATGCCTAGCGGGTTTTGTCTTTTGAAGAGTAGTTGTTGGTAGGAACATCAGATTTTTTTCTTTGAAATGAACTTTAAAAAAACAAAAACATTTTCGGCTGGTCACAGTAATCCCAGCACTTTGGAAAGCTGAGGTTGGTAGATCGCTTGAGCTCAGGAGTTTTGAGTCCAGCCTGGGCAACGTGACAAAATCCTGTCTCTACAAAAATTAGCTGGGTGTAGTGGCACACGCCTGTGGTCTTAGCCACTCCGGGGGATGAGGTGGGAGAATTGCTTGAGCCCAGGAGGTTGAGGCTGCTGTGAGATCGTGCCACCGCACTCCAGCCTGGATGACAGAGTGAGATCCTGTCTCAAAAAAAAGAACAAAAAACATTTTTAATGTATAGTTCAGGGGCTTTAAGTACATTCACCTTATTGTGTAATCGCCACCCGCTCTCTGTCTCCAGAACTTGTAAATTATCATCCCAAATTGAAATCTATACCCATTAAACAAACTTACTCTCTGCTCTTACTAGCTCCTGGTAACCACAGTTCTACTTTCTATCTCTGTGTGTTTGACTGTTGTAGGTATCTAATATAAGTAGAAAACACCTGATTTTGTTGGCCTAATTATTTTTTTAGATTTCTTATTTCTTCTTTCTCTCTTAAGTGTTAAAGTGTCATCATGGAACAGAAACAGATGAGGAAAAAATTGGTAACCCTAGAAGATTTTATGCTTCTGATTATTGAAAGATGACAGTTTTACTGGAGCA endometrial cancer 29334253 Circular RNA expression in extracellular vesicles isolated from serum of patients with endometrial cancer. Xu H, Gong Z, Shen Y, Fang Y, Zhong S. Epigenomics. 2018 down RNA-seq, northern blots extracellular vesicles isolated from serum of patients with endometrial cancer hsa_circ_0098964 circRNA homo sapiens SRGAP1 hsa_circ_0098964 AAACTCAGAGAATATTTGGAAGGCAGTAATCTCATCACAAAACTTCAAGCCAAACATGACTTGCTGCAGAGGACCCTGGGAGAAGGTCATAGAGCTGAATATATGACTACAAGGCCTCCAAATGTTCCCCCTAAGCCCCAGAAACACAGGAAGTCCAGGCCCCGCTCACAGTATAATACTAAGTTGTTTAATGGGGATTTGGAAACATTCGTCAAGGACTCAGGACAGGTTATTCCCCTCATTGTGGAAAGCTGTATTCGGTTCATCAATCTCTATGGTCTTCAGCATCAGGGGATTTTCAGAGTGTCTGGTTCCCAGGTGGAAGTCAATGATATTAAAAATTCATTTGAGAGAGGTGAAAATCCTTTGGCTGATGACCAGAGTAACCATGATATTAACTCAGTTGCTGGCGTTCTGAAGCTCTATTTCCGTGGGCTGGAAAACCCCCTCTTTCCTAAGGAAAGATTTAACGATCTGATTTCTTGTATCAGAATAGATAATCTCTATGAGAGGGCGCTTCACATCCGCAAACTCCTCCTGACTTTGCCCAGGTCGGTCCTTATAGTGATGAGGTACCTCTTTGCCTTCCTCAATCATCTATCACAGTACAGCGATGAGAATATGATGGACCCTTATAACCTGGCCATTTGCTTTGGCCCAACATTGATGCCTGTCCCAGAAATACAGGATCAAGTGTCTTGCCAGGCACATGTGAATGAAATTATCAAAACCATCATCATCCACCATGAGACTATTTTCCCAGATGCTAAAGAGCTGGATGGCCCTGTTTATGAGAAATGTATGGCTGGAGATGACTATTGCGACAGCCCATACAGTGAGCACGGTACATTGGAGGAAGTGGACCAAGATGCTGGTACAGAGCCCCACACAAGTGAAGATGAATGTGAGCCAATAGAAGCAATAGCCAAGTTTGACTATGTTGGGCGGTCTGCCAGAGAACTATCCTTCAAGAAGGGTGCCTCCCTGCTGCTGTATCACCGTGCATCTGAGGACTGGTGGGAAGGCAGGCACAACGGGATTGACGGGCTGGTGCCTCACCAGTATATAGTGGTGCAGGATATGGATGATACGTTTTCAGACACTCTGAGCCAAAAAGCCGACAGTGAGGCCAGCAGTGGGCCAGTCACGGAAGACAAGTCCTCATCCAAGGACATGAACTCCCCGACAGACCGTCATCCTGACGGCTATTTAGCCAG coronary artery disease 28045102 Peripheral blood circular RNA hsa_circ_0124644 can be used as a diagnostic biomarker of coronary artery disease. Zhao Z, Li X, Gao C, Jian D, Hao P, Rao L, Li M. Sci Rep. 2017 We verified the 5 candidate biomarkers by qPCR in another independent cohort consisting of 30 control subjects (CADS = 0, n = 30) and 30 CAD patients with different CADS (CADS 1¨C22, n = 10; CADS 23¨C32, n = 10; CADS > 33, n = 10). The results confirmed the findings of the microarray analysis, as the levels of these 5 circRNAs were significantly increased in the CAD patients; there was a 2.7-fold change in the expression of hsa_circ_0124644, and 2.2-, 2.1-, 2.0-, and 2.1-fold changes in the expression levels of hsa_circ_0082081, hsa_circ_0113854, hsa_circ_0098964 and hsa-circRNA5974-1,respectively. qRT-PCR, microarray peripheral blood from 12 CAD patients and 12 controls hsa_circ_0100094 circRNA homo sapiens RNF17 hsa_circ_0100094 GTTGCTACAGCTGTAAATACTAGACAACGCTACTACCCAATGGCTGGATATATTAAGGAAGACTCCATAATGGAAAAACTGCAGCCTAAGACGATAAAGAATTGTTCTCAGGACTTTAAGAAGACTGCTGATCAGCTAACTACTGGTTTAGAACGTTCAGCCTCCACAGACAAGACTCTTTTGAACTCATCAGCTGTAATGTTGGACACTAATACTGCAGAAGAAATTGATGAAGCATTGAATACAGCACACCATAGTTTCGAACAGTTAAGCATTGCTGGAAAAGCACTTGAACACATGCAGAAGCAAACGATAGAGGAAAGAGAAAGAGTTATAGAAGTTGTGGAGAAACAGTTTGACCAACTTTTGGCTTTTTTTGATTCCAG male infertile diseases 27958373 Identification and characterization of human testis derived circular RNAs and their existence in seminal plasma. Dong WW, Li HM, Qing XR, Huang DH, Li HG. Sci Rep. 2016 To validate these predicted circRNAs, 55 circRNAs of different abundance and lengths were randomly chosen for subsequent RT-PCR validation. Divergent primers were designed for circRNA detection. Among the 55 circRNAs, 30 of them could be specifically amplified. qRT-PCR human testis hsa_circ_0100095 circRNA homo sapiens RNF17 hsa_circ_0100095 GATAAAGAATTGTTCTCAGGACTTTAAGAAGACTGCTGATCAGCTAACTACTGGTTTAGAACGTTCAGCCTCCACAGACAAGACTCTTTTGAACTCATCAGCTGTAATGTTGGACACTAATACTGCAGAAGAAATTGATGAAGCATTGAATACAGCACACCATAGTTTCGAACAGTTAAGCATTGCTGGAAAAGCACTTGAACACATGCAGAAGCAAACGATAGAGGAAAGAGAAAGAGTTATAGAAGTTGTGGAGAAACAGTTTGACCAACTTTTGGCTTTTTTTGATTCCAG male infertile diseases 27958373 Identification and characterization of human testis derived circular RNAs and their existence in seminal plasma. Dong WW, Li HM, Qing XR, Huang DH, Li HG. Sci Rep. 2016 To validate these predicted circRNAs, 55 circRNAs of different abundance and lengths were randomly chosen for subsequent RT-PCR validation. Divergent primers were designed for circRNA detection. Among the 55 circRNAs, 30 of them could be specifically amplified. qRT-PCR human testis hsa_circ_0106101 circRNA homo sapiens KLHDC4 hsa_circ_0106101 GCCACCATCCGATGTCCACTCCGACCCGAAGGACCGCCTGTTGATCTAAAATGAAATAAACAAAAAGACACTATCAACCTGCTTAATTTCTGGTTGTTCTAAAGACGACAACAACAAACAAAATCCAATTTTTACACTGATTTCTGTTTTGTGAGCACTTACTGCTCACAAATTAAATACCATTTAATCTGATCTATCAACTACCAAAACCATCCTGCTAAGAGCCCAGCTAGCTAAGCTCAAACCTCAAGAATAAAACAGGAGAACATCTCCAAGACCTTGGACTGCATAAAGATTTCCTAGGTAGAACATTATAAACTGGACTCCGCCAACATAAAAAACTTCAAAAATACACCATTAGAAAATAAAAAGACAAGCAACAGACAGAGAAATATCTTGAAACACATGACTGACAAATGACTTGTATCCAGAATACATACAGAATTCTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGAGATGGACTCTCCCTCTGTCTCCCATGCTGGAGTTCAGTGGCCAGATCTCGGCTCACTGCAACCTTCGCCTCCAAAGTTCAAGCGGTTCTCCTGCCTCAGCCTCCTGAGTAGCTGGAATTACAAGCGTGCACCACCACACCTGGCTGATTTTTTGTATTTCTAGTACAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAAACCTCAAGTGATCTGCCTGACTCAGACTCCCAAAGTGCTGAGATTACAGGCATGAGCCACTGTGCCCGGCCCAGAATTCTATCTTAATAGTAAGATAAATGACCCAATAAAAATATAGGCAAAAGATTTGATCAGAAAGTTCGTAAGATAGAAAAATGGGGGGAAAAAAGATGGAAAAAGGCCAATGAAAAAAGGAAAGATGCCCAACATCACGAGCGGTCAGGGAAACATATGCCAAGTCCACAGTGACTTCCTACCACACATGGCTGGGCACCCGAGATCAAGACAACATCAAGTGCTGGCGAGGACATGGGGCTGCTGGAGCCATGGCACCGGTGAAAACGTAACACAGTGAAACAACGGTGAAACATAAACTTAGCGCACAGCTTAGCAATCTGACATAAGACATGGACTCAAGAGAAAGGAAAACACCAGTCCACACAGACGGACATGCACAAGTTTATACACGCTCTTGTGTCACCACCAGCAGCCGAGCTGTCCCTCAGTGGGTGAATGAACAGCATGTGGTGCTCCCCACATGGGGGAGGACTTCTCAGAAACAAAAAGGAATTGTTTACTGATGCACACAGCAATGTGAATGAATCTTAAAAACATCTCGCTGAAGGAAGGCAGGTTCTGCTGGACTCCATGCACACGAGCGTCTTAAAGGTGAGATCCGTCTTCGGCCCAGGATAGCTGCTCGGGGCAGGAGCTGGGAGGGGACCAACTACAGCTCTCTGGGGTGACAAGGGCCTACATCTTGTCTGTGGTGCTAATTACATAAGTGTGCATATTTCTTTTTTTTTTTTTTTTTTGAGACAGCGTTTCATTCTTGCCCAGGCCGGAGTGCAGTGGTGCAATCTCGGCTCCCTGCAACCTCCGCCTCCAGGGTTCAAGTGAATCTCCTGTCTCAGCCTCCCAAGTACCTGGGATTACAGGTGCCTGCCACCACGACCAGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCATCATATTGGTCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATTTGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCCTCTGGTCAGGTGTGTATATTTCTTAACACTCATCTAAGTGTACATCTAAAAGGCATGCATTTTATTGAATTTTATTGTAATTATGTCTCAATAAAACTGATATAAAAATACATGGCAATAAAAAAATACAAAAAGCAAATTTAAAACCTTAAAAATACACACAAATAATACAATCACACACAAATAACACATAAATAACTACAATCAACCTCCCTAGTAATCAAAGAATTTCAAATAAAGCAGAGATACCATTTTATTCTATCAACTTGACAAAGATGTTTAAGAATTAGATTCTTTAAAATACTGCATGTCACGGGACAATGCTCGAAAAACAGCACGTGAAAAGGCAGGTCCAAAGCAAATCCTATCCCAGCTTCTACAGGTAAAAAGGCAGGTGCAAAGCAAATCCTATCCCAGCTTCTACAGGTGAAAAGGCAGGTGCAAAGCAAATCCTATCCCAGCTTCTACAGGTGAAAAGGCAGGTGCAAAGCAAATCCTATCCCAGCTTCTATAGGTGAAAAGGCAGGTGCAAAGCAAATCCTATCCCAGCTTCTATAGGTGAAAAGGCAGGTGCAAAGCAAATCCTATCCCAGCTTCTATAGGTGAAAAGGCAGGTGCAAAGCAAATCCTATCCCAGCTTCTATCGGTGAAAAGGCAGGTGCAAAGCAAATCCTATCCCAGCTTTTATCGGTGAAAAGGCAGGTGCAAAGCAAATCCTATCCCAGCTTCTATCGGTGAAAAGGCAGGTGCAAAGCAAATCCTATCCCAGCTTCTACAGGTGAAAAGGCAGGTGCAAAGCAAATCCTAACCCAGCTTCTACATGGGTGGTTCTCAGTGGTTTTCTTGTCTTAATCGTTTCCTGCATCTCCCAGCAGTCCTCCAGTGAGCAGGCGTGACTTTCACAACCAGAGAGAGGAGCAACAAAACAGACAGGGGTGGTGAGGAGGCGCTCGGGCAGCAGGTGCTCAGAAAGCTCGCAGAGGTGCTTACGCCGGCCACAGATGTGCAGGGCGCCCAGGCACAGAGGAGGCGGGGCACACAGGAATGGCTTTGGGCTGCAACATCAGGCTGAACAGGGTGCGTGTGCTGGGACTACCCAGGGAATCTCCTAGAGCCGCAGGCACCAGGGCAGGGCCTTAAGGAGGGTTGCTGGGCACAGTCACTGCAGCCACTCCCTGGGATCCTCACTGATGACCTGCCTCGCCTCCTACTTAGGAATCCACTCCCTGGGATCCTCACTGATGACCTGCCTCGCCTCCTACTTAGGAATCCACTCCCTGGGATCCTCACTGATGACCTGCCTCGCCTCCTACTTAGGAATCCACTCCCTGGGATCCTCACTGATGACCTGCCTCTCCTCCTACTTAGGAATCCACTCCCTGGGATCCTCACTGATGACCTGCCTCGCCTCCTACTTAGGAATCCACTCCCTGGGATCCTCCGTGGCTTTCACACCCACTCTCTGCCTGGCCCTCCCACCTCTCCACACAGGTCACAGCAACTCTGGGCTGCAAAGGATGGTTACAGCTTCAATCACGCAA endometrial cancer 29334253 Circular RNA expression in extracellular vesicles isolated from serum of patients with endometrial cancer. Xu H, Gong Z, Shen Y, Fang Y, Zhong S. Epigenomics. 2018 down RNA-seq, northern blots extracellular vesicles isolated from serum of patients with endometrial cancer hsa_circ_0106632 circRNA homo sapiens TMEM98 hsa_circ_0106632 GTAAGGAGACCAAAGCAGAAAGATCAGTAACCCTCCTGGAGTCTCACAATTAATATGAATCAGAGCAGGATCTTCAACTCCTCAACTTGTGTTTTTAACTGGCACATCTTCCTGCCTGGGTGCAGCAGGTGGGAAATCCATCATGGAAAGGAAAGAACAGACATGAGAGTCATTCCATTCTCTTCCAGTTCAAATCTTTTTTTGTGAAAAAAATGGTAGTTGTGACCCATGAATTAATTTCACGGCCCACTAATTGGTTACAACCCACAGGATGATAGAACATAGGTACTAAAATGAGGGCTGGGGCATGGGTGAGGTATTTCCTCTCCTTCCAAAATGACTTAATTTTATCCATTTAAAATAAAATTTGCATTTACCAGAATAGTGGCAAAAATTTATTGTGCAGAATAGAATAATTGATTTATTACATGAATGATTAGTTCAAGAGTCATCTGTTGAGCATCTGCACTGGATTAGGCCCAGAGATGCATGAATGAATAAAAAGATAATGCCTCTCTTGAGGTGCATATAATCTAAGGTGGAAAGAAAACCATAAAGAGGCATTTTCAATACAGTGTGGTAAGGGCTAAGGGAGGGAATGTGTGTGTGATGACAGCGCAGAGCAGGACCACCAAACCCAGGTCATGAGAGTTTCCTAAAGGTGGTTACATCTCAGAATAGTCTGTCGAGGAGTAGGTGTTAGGAGAAGACAGGGTGGGGTTGGGAAGGTGGAAGTGGAGGACAGAGCATCCAGGTAGGGCCATCTTGCAGACATGACATTCCATGCCATGCTCAGGACATGTTAGCTGCTTCAGTACTGTGAGTGTCAGGTGGGAGCTGTGGCATGGTAGGAGGTAAGCCTGGGGAAGAAGGTGAGGATGAGACTCTGGAGAGTCTCATAGGCCTTGCTGAGGTCTTTGGACTTTTTCTCTAGGTGATAGGGGGCAATTGAATGTTGAAAATTGTTTTCTTATTTTTTTTCCTGGGGCATTAGCAATTGATCACTGCACCCTCACCAGCCTTTAATGTTTTCCTAATTTGATAGGTGAACAATGGCCTAGCATTGTGTTAATTTGCATTTCCCTGACTACTGGTGCAGTTAGACATTTTTTTTTCAGGTGTTTATTAGCTATTTGTACATATTCATGCCCTTTGCCCATTTTTCTACTGGGATTTTAGTATTCTTATTGACTTATATGAGCTCTTTATATATTAAATATAACAACCCTTTGTCATATTTATTGCATATATTTTCACCCAGCTTTGTCATTTGCTTTTTAGTTTTGTTTACAATGGTTTCTGATGTCCAGAAGTTTCAAATTTTGTGTAGTCAAATTTATTGATTTTCTTTTTGTTAGTTATTCCTTCCATTGCTTTTATACTTTCTTATCTAGAGATCAAATAAATATTGAGAGCTGGAGCTATGGAACAAAAGGCACATAATAATATTCACATGTTAGGTGTAGTGGCAGAAAAAAACAACAGGGTAGAAAAAACCCAAACCTTCCTTTATCCACCCCAAATCCACCCCAATCCACCCAAATCCTGTGGGAACAGTCACAGGTCAAAGAAATAGACAAGAATGGTGAGGAGAGGAAGGGAACACCTTGAAGGACGAGTAGGAGCTGGTCAGGCATACAGGGTGTGTGGGAGTAGCACAGAAAGGAAGCTGCATGTCCCAAGGTAGAGGATGAAGAGACAAGCATGTCTGAGTGCGGGGGATGCAGGGCAGAGAAAAGCCACACAATTTCTGCTCTCATGAGATTGTAGTCTGGTGAGGAAAGACATACATTAAACAAAATGTTGCTTAAATAAATGTAAAATGAAAACTTTAAAAGTGTTGTAAGAAAATAATTTGAATCTTATGAGAGATTATAAGGGAAACTGATCTATCTAGATGTCAAGGAAGGCTTCCAGTAAGAGGATCTTTGATATACTATCTGGAGGATAAGTAGGAGTCCAGAGGTGAAGAAGTGGATGTATGAGAAACTGTACATGTAAAGGCCCTTTGGCAGAAGGACAAGAACTGAGACCAGGCCAGTGTGACTGAAGAGCAGAGCAGACAGGGAAGAAGGCCAGGTGAAAATGGGGGAGGGACTGAATCATGCCAGACATTGCAGGCCATGTGAAGGACTTTGGTCTTTCTCTGAAGAGTGATGAGAACCCATTCAAATGGTTTATTCAGATCTGGTGGGTTTTGATTAGAGGTGGAGACATAATCAGATTTGTATTTTGAGAAGATCCTTTTGCCTTCTACGTGGAGAACCAATAGGAGGAGGCTGGAGCAGATAGGAGCTGCCTGATGCTGCTGCAGCAGTCTAGGTGAGAGATGATGGTAGCTTGGTCTAGGCAGGGAGAGGAAGATGGAAAGGGGAGTGGAGCATTTGAGAAATGTTTAGGAAGTAAAATAAATAGAATTTGGGTGGATTGGATATGGGACAGTGATGCAAGATAATAGCGTGCCAAGAAAGACTCCTAGGTTTCAAGTTTGCACACTTATATGGGGGTGACAGTTTGGGGCTAGGGGTCACTGGTACAGGAAGCACCAGAAGAGGATCAGGTTTGGGGACGAGTTTAAAGTCATCCGTTTTGGAGTTGAAGAGTTTGCGGTGCATTTGAGATATCTGAGTTGAGTTAGAGATATAATGGTTGGAGCTCAGAAAAGACTGGGCTGAAGGCTTTTCATTAAGTTATTAAGAGAGTTTTGGCCATGGGTGCAATCCTAGGGAGAGAGTGTGGAGTGAAAATTGCAGAGGGGTGTGAGATACTCTTAACATCGAATATGATACTGGGCCAGTTCAAAGCTCTGTACTGTTATGTTGATGGCTAAATGAAATTGCATATGCCCAGTTCCTGGCACACAGTAGGCACTCAGTAAATATTAAATATATCTCCTTTTTCTCCTTTGTTTCTCTGCTCCCTTTATTCTATTTCTCTCTCTTTTCTGGCTCTATGTATTACAGCCAGAGACTCAAGCTGACTTCTTTCAACTTCCCCAGGGTACCTAGTGCACAAACCTGGCATACATCGCTCTCCTCCAAGACCCAGCCTGGGAGAGCCTACCTCTTGAGAGCTGTCTCAAGCTGAA endometrial cancer 29334253 Circular RNA expression in extracellular vesicles isolated from serum of patients with endometrial cancer. Xu H, Gong Z, Shen Y, Fang Y, Zhong S. Epigenomics. 2018 up RNA-seq, northern blots extracellular vesicles isolated from serum of patients with endometrial cancer hsa_circ_0108942 circRNA homo sapiens ANKRD12 hsa_circ_0108942 ATCCAGGATGAGAAGACTGATAAAAGAAGAAGCTAGCTGAACAGCTGTAAAATGCCCAAATCTGGGTTCACAAAACCAATTCAGAGTGAAAATTCTGACAGTGACAGCAATATGGTAGAGAAACCATATGGAAGAAAGAGTAAAGACAAGATTGCATCCTACAGCAAAACTCCAAAAATTGAACGAAGTGATGTGAGCAAGGAGATGAAAGAGAAATCATCCATGAAACGTAAACTTCCTTTTACTATTAGCCCATCAAGAAATGAAGAACGAGATTCAGACACAGGTAGAATAATTTGCTGTTCTCTGGTAAAATCTTGCCCATTCTTTAATTCTGATTTTTGTTTCTTGTACACCACTCCTCTTGACACCCCAGTTTATAGAGAAATATTTGTATTTCACTATTTCAGATTTATCATTTTGGGGTAGGAATTCCATCTATCATGCCAAGTGTGATTTCTAACCAGAGATAAAAACAATTTTCTTTATTCCTTACTCTTTGAATGTTTATTGTGAATTTCTTTATCAAGAAATTAATTTTGGGAGGAGCATTCAAATGAATAAAAATTACTCAGTGATAAGGAAGCATTGGGATATGCAGATTTGAGAAAAAGTTGTTGAGCTTTTGTGAACATATGGTCACACCCCAAAGAAGTTTAGGCACTTTAGATTCAGAAATAAATTAGAAACATGCAAACACACACACACACACACACACACACACACACACACACACACATTGAGGCTAACTGCCTCAGTGCTTTTCATAGAATTTTTACACACACACACACACACACACACACACACACACTGAGGCTAACTGCCTCAGTGCTTTTCATAGAATTTTTGTTTCCCAAAACTCCTATATACCAGAAATTGATACTTGAAATCAGCCAATCCCAGTTATTCATAACGGATGAGATTCTTTTTATTGCTATCTAATAAATTACTAGGTTGTGTTTTAGCCCTGAACTAACCGATTTTTGAAACTAATATAAACTTGAATGTATGTATTTACTGTAGTTTTAGTCATTGCATGAAATATTAATAATGAACTGTTCTTAAAAATGTTTTAGCCTCAGAGAAAGTATTCCATTCTGAGTTTACGTACATAGATTATATTCTGCCTATATCTTTCTAGTCATTTTAATTGTCAGTTCAGAAATGATCTTGACTCTGGAAACTGAAAATACTCATAAAGATTTTTGAAACATTCTATGCTAACATAGCTTTAGAAAATCATGTAGTGTATGCTTTTGGTAGCCAGGTCTCCTTTTGTGTATTTTGCCACTGCTGTTGTGTGAATTAAAAATTGTTCTTAAACACTCATGACATTTTTAAACTTTGAAGATTGCTCTGTCTTGCAGTGATTACGAAATCATGTGCTTTTTCATTTTAAGCTACACTGGTTTCTTTGAGAGATTCAGAATCTTTTTTTTTTCCCCCCGAAGCATCCTAAGTGATACTCTCAAGCTAATTACTGGATCGCTTACCTGAGAAGAGGGTGCTTATGTGCCTTTGGGATAGCTATTTCAGATTGAACTCTTCTCGCATATTGTTAAAAGTTTCTTTGCTAGTCATTTTTAAATTACATTACTCGGGTTTTGTTTTCCAATGAGAGTATATTTCTGATAGCTGTTCGAAAAATGGATTTTGATAAATTCAAAAAATATTAATATTTTTAAGGAATAAAGTTTCAAGATAATCTTTTCATGAGAGCCTTTGTCATTAGATCAGATGGATTATTTTTCTTTTATTTAGAATAAAATTAAGGAGAAAATGTTACTTAGGAAGGTAAGAAATTTAGGCATTGAATAAATGTAACCTAATTCATATGTCTAAAATTGGGTTATATACACTTTTCCCCCTTAGATTTTTTCTACCGTTGGACTTTAGTTGGGATATCGCAGCTCTCTATAAGACTGTTTCATAACACTTATTCTTCCTTTTGAAAAGTTAACATGTTGTCACCAAACAAAATTTTGATGGATTTAAAACACAATTGACCCTCGAATGGTGTGGGGACTAGGGGCGCCAACCCCCTTTTTCCCCCTTCACACAGTCAAATCTGTGTATCTTTTGACTTCCCAAGTACTTAACTACTAATAGCCTGCTTTTGACCAAAGCCTTACCAATAACATAAACAGTCAATTAACACATCTTTTGTGTGTTACGTTATTTTTTTCTTTACTGTTACCTGAGATGACGTGTTATATTATTATATACTGTACTCTTTAAGCTAGAGAAAAAAATGTTACTTAAGAAAATCATAAAGAACAGAAAATATATTTACTATTCATTAAATGGAAATGTATCATTATAAAGATCTTCATCCTCATTGTCTTCACATTGAGTAGACTGAGGAAGAGGAGGGGTTGATTTTGCTGTCTCAGGGATGCAGGGAGGCAGAAGAAAATTCCTGTGTAAGTGGATCTGTGCAGTTCAAAATCAGGTGGTTCAAGGTCAATTGTATTTATATTTTTGGTAGGCTTTATTTATAAATTTTAGTAATAGATGACGTCTTTGGTTTAACATATCACAACACAGTGAAAACATTAAGGAGGATTTCCCTAGTCCCAGTACAAAATGTGTTATTTACGATTCAAGTGTCTTTTATATAATTTTTTTTTAAAAAGTAGAATTCAGTACCATTAAGTGATATTTCCCATATGAAAGATACAGCATCAGACTTCATATCTGACATTGATCTTTTTTATGTAGTATTCTGTATTTTAAACTATTAGCTGAAACTGTGAAGATAAAGATACAGAGGGGAGAAACATTTACAGCATATATCAAAACCCTTAATATATGTAGTATTTAAAGATCTTCTAAGTGTGAAAAGGAAACTCAAAAATGGGAAAATGGACCAGAAAATACAAGTGGTTCAGAACAATTATAGTTTGGAAAGAAATACATGAAAAAAATACATCAATAGTAATCAAGAAATACAATTTATGGTGAATGACAAAATTGTTTTTGGTCTGAATCACCCAGTGGTTATGGGTTGGACATAGGAATTTGCTTTAGTGGGTCTAAATTATAGAAATACTTTGTTTAAGGTAAATAGGACAGTGTATATAAAAAGTTGTTTCTTAACATCTGACTAATTTTTTCTTTGGGCATTTATTATAATAATGATAACTATTATTATTTTGAGACAGAGTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGTGCCATCTCAGCTCACTGCAACCTCTGCTTCCTGGGTTCAAGTGATTCTCCCGCCTCAGCCTTCCGAGTAGCTGGGATTACAGGCGCCTGCCACGATGCCTGGCTAATTTTCATATTTTTAGTAGAGACGGAGTTTCACCATGTTGGCCAGGCTGTTAACTCCCGACCTCAAGTGATCTGCCAGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGAGTGAGCCAACATGCCTGGCCTCTAATAATTACTGATGAGAGCATTTATCTTTAAGAATGTTTATCTCAGCTTTCTTTATAATAGCAAAAAAATCAGGAAAATTGTGTTGAGTAATATAGGATTTGTTAAATTATGATAAATTCAATGAAGAAATAGATTTTTCACCCTTAAAAATAATGTAGTAAGGCTGGGCATGGTGGCTCACACCTGAAATCCCAGCACTTTGGAAGGCCAAGGCAGGAGGATCACTTGAGGCCAGGAGTTTGAGACCAGATTGGCCAGCAGAGTGAGACCCTATATCTATAAGAAAATTAAAAAATGAGTCAGGCTTAGTGGTGTGTGCCTGTAATCCCAGCTACTCGGGATGCTGATGCATGAGTATTGCTTGGCCTGGTAGGTCGAGGCTACAGTGAGCTGTGATCATGCCACTGTACTCCAGCTGTAGAATAATACGTAATATGGGAAGGTGATCATGATATTGGAAGTAAAAAATTAGATTATGAAACAGTATGTGCTATTTGCATTAAAATTGTAATTTGTGTATTTACATTTACTGTGTGTATATACGTGCACACATGATGTATATTAACACATGGAAAGATTAAGACTAAGACTTTTTTCACTGTAGGAACTGTACCTGTTGGATGTGTTTTGGGTACAGAACAAAATATAAATGTTATAAACCTTGACGTAAGGAAATAACAGAAAAAAGGGTAGGGAATAAGGAGAAAGCATATCATCTTATCTCTAGCAAGGGATTAACTGATATTATCTAAACAAGTATATAGTTTCTTAAAATGATTATATAAACTTTTTAATGTTCCTGTATTTAAAATTCCTTTATATTTTTGTTTATATTTTATAGTAGACAGTGTCTTTTATAAAGAAGCAATGCCTTTAGTTTTTTTTAATGTTGGATTAAAATAATCTTTAAGCCTTTTATTTCAAAACAGCATATGTATGTTATTTTCTTGTTCTTACATAAATTTATTACTGTCTCTGCTAGTTCCTTTGTTGTTTTATGTGTTTAGAGGGATGCTGGGAATGATGCTTGCCAGAGGTTAACACTTTATTTCTTGGATGTGGGGTATTTATTACTTCCTTCTTGGTCCTTTTTGTATGGCTTGAATTCTTGAGATAATGGTCATATGTTACTTTTATAAAGTCACTACTTTTTAAAAGAGGTATTCATAGCATTGTCCAAGGAAAGCCTACTGGCACCCCAAATCAGCAGTAATGCTGTCTACTGAATGAGAGATTCCTAGCCTTCATTTTGCGAGATATCGTAGTGTGTCTTAAACTTTCTAAATTCTCAATTATTTAATACTTACTAATTTTTTTAAAAAAGAAAACACTTTCTAGAAAAGTAATTGCTTGGCTAGACAGGAGAAATTAGGGAATGAATTACAACATAATTTGAAATCAGGCCAGTGGGTCCTTGTAGCTCTATCGTAGTACTATATTTATTCTGAATTAATTTATTTAAACAAATCACCAACATATTATTTTACTCTGTCAAAGAATTCCCATAAATTTTGTCCTGTGGAATATTAAGCCAATGTATACAGTGACCCATTGAACCTATGGAAGCAAAAAGCAACTGCTTATCTAAAAGATATTTCTTACACCTACATCAGCTTGCTTTATCACTAATTTTTACCTTTTCCTTTTATTCTCTCCTACTCTAGAATTGACAGGATAAATTTTATAGTTGTAACAGAGGTAAATCATGGCAGTGTTTACTGTTGAAGATTTTGGAATCTGACTAGTGTTGACCCTAAGCCCCCTACGAGCACTGGCCCAGTAATTAGACTTCTTT breast cancer 29045858 Circulating circular RNA hsa_circ_0001785 acts as a diagnostic biomarker for breast cancer detection. Yin WB, Yan MG, Fang X, Guo JJ, Xiong W, Zhang RP. Clin Chim Acta. 2017 upregulated in breast cancer microarray, qRT-PCR breast cancer peripheral blood specimen hsa_circ_0109046 circRNA homo sapiens ZNF700 hsa_circ_0109046 GACCCAGTGGCCTTTGAGGATGTGGCTGTGAACTTCACCCAGGAAGAGTGGACATTGCTGGATATTTCCCAGAAGAATCTCTTCAGGGAAGTGATGCTGGAAACTTTCAGGAACCTGACCTCTATAGGAAAAAAATGGAGTGACCAGAACATTGAATATGAGTACCAAAACCCCAGAAGAAGCTTCAGGAGTCTCATAGAAGAGAAAGTCAATGAAATTAAAGAAGACAGTCATTGTGGAGAAACTTTTACCCAGGTTCCAGATGACAGACTGAACTTCCAGGAGAAGAAAGCTTCTCCTGAAGTAAAATCATGTGACAGCTTTGTGTGTGCAGAAGTTGGCATAGGTAACTCATCTTTTAATATGAGCATCAGAGGTGACACTGGACACAAGGCATATGAGTATCAGGAATATGGACCAAAGCCATATAAGTGTCAACAACCTAAAAATAAGAAAGCCTTCAGGTATCGCCCATCCATTAGAACACAAGAAAGGGATCACACTGGAGAGAAACCCTATGCTTGTAAAGTCTGTGGAAAAACCTTTATTTTCCATTCAAGCATTCGAAGACACATGGTAATGCACAGTGGGGATGGAACTTATAAATGTAAATTTTGTGGGAAAGCCTTCCATTCTTTCAGTTTATATCTTATCCATGAAAGAACTCACACTGGAGAGAAACCATATGAATGTAAACAATGTGGTAAATCCTTTACTTATTCTGCTACCCTTCAAATACATGAAAGAACTCACACTGGGGAGAAGCCCTATGAATGTAGCAAATGTGATAAAGCATTTCATAGTTCTAGTTCCTATCATAGACATGAAAGAAGTCACATGGGAGAGAAGCCTTATCAATGCAAAGAATGTGGAAAAGCATTTGCATATACCAGTTCTCTTCGTAGACATGAAAGGACCCACTCTGGGAAAAAACCGTATGAATGTAAGCAATATGGGGAAGGCTTATCCTATCTTATAAGTTTTCAAACACACATAAGAATGAACTCTGGAGAAAGACCTTATAAATGTAAGATATGTGGGAAAGGCTTTTATTCTGCCAAGTCATTTCAAACACATGAAAAAACTCACACTGGAGAGAAACGCTATAAATGCAAGCAATGTGGTAAAGCCTTCAATCTTTCCAGTTCCTTTCGATATCATGAAAGGATTCACACTGGAGAGAAACCCTATGAGTGTAAGCAGTGTGGGAAAGCCTTCAGATCTGCCTCACAGCTTCGAGTGCACGGTGGGACTCACACTGGAGAGAAACCCTATGAATGTAAGGAATGTGGGAAAGCCTTCAGATCTACCTCACACCTTCGAGTGCATGGTAGGACTCATACTGGAGAGAAACCCTATGAATGTAAGGAATGTGGGAAAGCCTTCAGATATGTGAAGCACCTTCAAATTCATGAAAGGACAGAAAAACACATAAGAATGCCCTCTGGAGAAAGACCTTATAAATGTAGTATATGTGAGAAAGGCTTTTATTCTGCCAAGTCATTTCAAACACATGAAAAAACTCACACTGGAGAGAAACCCTATGAATGCAACCAATGTGGTAAAGCCTTCAGATGTTGCAATTCCCTTCGATATCATGAAAGGACTCACACTGGAGAGAAACCCTATGAGTGTAAGCAATGTGGGAAAGCCTTCAGATCTGCCTCACACCTTCGAATGCATGAAAGGACTCACACTGGAGAGAAACCCTATGAGTGTAAGCAATGTGGGAAAGCCTTCAGTTGTGCCTCAAACCTTCGAAAGCATGGTAGGACTCACACTGGAGAGAAACCCTATGAGTGTAAGCAATGTGGGAAAGCCTTCAGATCTGCCTCAAACCTTCAGATGCATGAAAGGACTCACACTGGAGAGAAACCCTATGAATGTAAGGAATGCGAAAAAGCATTCTGTAAATTCTCTTCTTTTCAAATACATGAAAGGAAGCACAGAGGAGAGAAGCCCTATGAATGTAAGCATTGTGGGAATGGATTCACATCTGCCAAGATTCTTCAAATACATGCAAGAACACACATTGGAGAGAAACACTATGAATGTAAGGAATGCGGAAAAGCATTCAATTATTTTTCTTCCTTGCATATACACGCAAGGACTCATATGGGAGAGAAGCCATATGAATGTAAGGATTGTGGGAAAGCATTCAGCTAGCCTGGTTCCTTTTATGGACATGAATAGACTCACACTGGAAGGAAGCACTATGAATGCAAGCAATGTGGCAAAACTTTCACATTTTCCAGTTCTTTTCGATATCATGAAAGGACTCACACTGGGGAGAAACCCTATCAATGTAAGCAGTGTGGGAAAGCCTTCATTCCTTTTACTTCTTTTCAATGTCATGAAAGGACTCACACGGGAGAGAAACCCTATGAGTGTATTCTAGTTCCGTTTGATATCATGAAAGGACTTACACTGGAGTGAAACCCTATGAATGTAAGCAATGTGGGAAAGCCTTCAGATGTGCCTCGCACCTTCAACGGCATGGAAGGGTTCACACTTGGGAGAAACTCTATGAAT endometrial cancer 29334253 Circular RNA expression in extracellular vesicles isolated from serum of patients with endometrial cancer. Xu H, Gong Z, Shen Y, Fang Y, Zhong S. Epigenomics. 2018 up RNA-seq, northern blots, qRT-PCR extracellular vesicles isolated from serum of patients with endometrial cancer hsa_circ_0109271 circRNA homo sapiens PBX4 hsa_circ_0109271 AAAGCATGCTCTGAATTGCCATCGGATGAAGCCTGCTCTGTTCAGCGTGCTCTGTGAGATCAAGGAAAAGACAGGTAGGCTGTTTAGAAGACACTTTCTGGCCGAGCGTGGTGGCTCATGCCTGTAATCCCAGCACATTGGGAGGCGGAGGCGGGCAGATCACCTGAGGCTGGATTCCAGACCAGCCTGACCAACATGGAGAAACCCTGTCTCTATTAAAAATACAAAAATTAGCCAGGCGTGGTGACGCATGCCGGTAATCCCAGCTACTCGGGGGGCTAAGGTAGGAGAATCGCTTGAACCTGGGAGGTGGAGGTTGCGGTGAGCCAAGATCGCGCCATTGCACTCCAGCCTGGGCAACAAGAGTGTGCGGTGAGCCAAGATCACGCCATTGCACTCCAGCCTGGGCAACAAGAGTGAAATTCTGTCTCAAAAAAAAAAAAAAAAAAAAAGGCACTTCCTGTGTGTGACTAGAGCTGCGGCAGCACACCTCTGATCTTGTCTCAGCCCTTATGTGCATGGTGGGCCGTTTTGCTCATCCCTTCTGTCTCGCAGAAGACGGCTAGGATGTTTTCTTTCTGCCTTATCATTGCCCTGGTTTCCAGTATGCACACTGATTTATTTTGTAGTTTATAACTGAGAAATACTGTTGCAAATCAGTAACAAGCAGCTGCATTCTAGGTCGAAGACCTAAGAGGTGCTTAGCATTCAGTCATATAGAAAAAGGAAAAATGACAGACTTAGGGAAATTGAATAAGAACAGTTTTGTCGGCTGGGCACAGTGGCTCATACCTGTAGTCCCAGTACTTTGGGAGGCCGAGGCAGGTGGATCACGAGGTCAGGTGTTCAAGACCAGCCTGGCCAAGATGGTGAAACCCCCATCTCTACTAAAAATACAAAATTAGCCAGGCATGGTGGCACATGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCACTTGAACCCAGGAGGTGGAGGTTGCAGTGAGCCGAGATCGCGCCATTGCACTCCAGCCTGGGCAAGAAGAGTAAGACTCCGTCTCAAAAAAAAAAAAAAAAAGGAAAGAAAAGAAAAAGAAAAGTTGAAAAAATAGTACAGAGAGTTCTCGTATCTCCTTCTCCGGGCTTCCTGTCTCGTCAACACCTTCAGAGCCATAGTACAAATATGGAAACCAGGAAATTACGCTGAGTACAATGATCTTTAACTGAACTACAGACCTCATTTGGAGTTCCCCAGTTTTTGCCCTAATGCCCTTTTCTGCCCTGAATCCCACGTTGTATTTAGTCATCATGTCTCTTTGGTCTCCTGTGATCTGTGACCTTGTCATCCATGAATGACGCTGACCATTTTAAGAAGCGCTCAGTCATTTTGTAGAACATCCCTCAGTGCGGTTTGTCTGATGTTTCCTCTAGATTGGACTGAAGTTGTGCATCTGTGGCCAGAGTCCCACAGAGGCAATGTGTGTGTCCTCAGCACATTGTGTCAGGGAAAACATGCTGTCAATATGTCCTGTCACTGCTACCATTGACCTTGATCACTTGGTCAAGGTTAATAACAATTTGAAAGTAGCTTATAAGTGGGGCCACCAAATAAGATGAAGATATTTAAACCAAGGGTCATCTGCACAACGTGTCACTTGATTTCTTAGAGTGAGTTGGTCTCTTGAGGTCAATTATTTGAATTTTGTGTGTCACTTTGGAGCATAGCACTTCATATTTGCTGAGGCTTGTGGAAAGTGTGTGTATATGTTGTACAAAAGTGTGCTTCTTTCTGAACACTGTTTTGGTGCAAGATTGATGTGTACTTGACATATATAGTAGTTGAGAACAGCAAGAGGGTCTGAATTCTGCCTCCACCTCTGGCTGCATGACCCTGGTCCTTGGCTGAACCTTTCTCTGTTCCTGGTCCTCCTCTGATTTGTGGGGCAATAATAATACTTAGCTCATGGTTACTGAGGACTGTTGAGGGCTGTGTGAATTCATATATGTAAGGCTGTGGGCATGGTGCCCAGCCTTCAGAAGAGATCTGGTGACTAAAGGAGAAATTCAAGTTTAAATCTACATTTAAGTTTCGCCTAAATGCTATGAGGACATGATGTCCCTAACCCTCCCCAGTGTAAATTTATTTTTATTTTTATTTTTTGGAGATGGAGTTTCACTCTTATTGCCCAGGCTGGAGTGCAATGGCACGATCTTGGCTCACTGCAATCTCCGCCTTCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCTGAGTAGCCGGGATTACAGGCGCCTGCCACCACACCCAGCTAATTTTTTGTATTTTTTATTAAAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCGCCTGCCTGTCTGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCATCACACCTGGCCTTTTTTTTTTTTTTTTGGAGACAGGGTCTCACTCTGTCACCCAGGCTGGAGGGCAGTGACATAATCTTGGCTCACTTCAGCCTCCTGGGTGGGTGATCCTCACACCCCATCCTCCCAAGTAGCTGGGACTACAGGCACGAGCCACGTTGCCCAGCTAATTTTTGTATTTTTTGTAGAGAGAGGGTTTTGTCATGTTGCCCAGGCTGGTCTCAAACTCCTGGCCTCCCAAAATGCTGGGATTATGTGTGTGAGCCACTGTGCCCAACCAGGCTCATATTCTGTTCTGCCTCTGCCTGCTTCACCCAATTCTCTAAGGAGCCCTGATTCCTTTCAGAGTAAATCTTGGCCTTTGATGTGCTCATTGCTGTTGGGGTGTTGCTGCTCTTGGACACTCTTAGGACACAGAGCTAAGGAATATTTGTGGGTTATTACAGATGCGTGTGTACACACACACACGTGCGCACACATTCACATCTGTTTTCCTATGTTTTTATATATTAAAAACCATGAGTTCATTATGATATCTTTATTTTTGTTTGTTTATTTATTTATTTATTTATTTATTCTCACTCTGTTGCCCAGCCTGGAGTGCAGTGGTGCAATCTCAGCCTCCCAGGTTCAAGCATTTCTCCTGCCTCAGCCTCTGAGTAGCTGGGATTATGGTGTGCACCACCACGCCTGGCTAATTTTGTATTTTTAGTAGAGACAGGGTTTCATCATGTTGGCCAGACTCGTCTCAAACTCCTGACCTCAAGTGACCTGCCCGCCTCAGCCTCCCAAAGTGCTGGGATTAGAGATGTGATCCACCGCACCCAGCTTATTTTTATTTTTGAGACAGGGTCTCACTCTGTCACCAGGCTGGAATGCAGTGGTGAAGTCACAGCTCATTGCAGCCTCAACCTCCTGGGCTCAAGCAATACTCCCACCTTGGCCTCCCAAAGTGCTGGGATTACATGCATGAGCCACTGTACCTGGCCCACTCCAATATCTTTAATTCTAGTTCACCACAGGGTTCCCACTATTTTTCTCTCTTCCCAGGTTTGTGACTCCTTCCTCCAACAGTGAGAGCCTGCTCCTGTTGTCCTCAGTACTTTTGCTTGTGTAATCAATCTCCCACCTCCTTCACCCCCAAGTATACTTAATCCCCCAGCCAAGCAGACCCCTCCTTGTCCCCACCCCCCAGCAGACTGCTGCTGCTGACAGCCCCCACATGATATGCCCCCTGTTGGTCTCCAACACCCAGTGCCAGGTCATCCTCCCGACGGGGCCAGATGCTGGGCTGTGATGCCCCTGGCTTCCTGCCCACCTCATATGCCTCTCATGGGTATGTAAATATCTGATGACCTGTCTTATCTGTTCCTTATTTAAATTGTGGGGAGCAGATGCCATGGAAATGGAAACACAAAGGTTAGGCTTTCCTGGGGAACCAGACACACAAGTTTCTTGTTAGCGGTGAACTGGTTTTAAGCAAATTTGCCCTCAACTCCCTGGCAGCACTCCCTGATGGTGCTTCAGCATTCGTGTGGTAAGCTGGACAAGCGGGGGCCCTGTACCCGAATGAGCCCCAAGTACTGCAGGCTGAGGGAAGCCGCTCAGAAGGACACAGCCAATGTGTATCCACCCCCTGGAGACACTGGCTGTGGTCACGTGTTTCTTAGTATTGTGGAATTGTGTAATGTTGGTCCCTTTCACTTTTCACCTAATAAAAATAAGCCAGTGTCAGGACCACTTGCTGAGGCATGTGTACCAATAGGCACAGGCAGCCCAAGTTGTCCCTTGCTCACCCCTGACCCTGACCCCAGGAAGCAGCCTTTGGGGGCTCCCCACTGCCCACAGCGGATGTTTAGCAATGCAACATCTGGAATTTAGTAATAATAAAAAACTATTTTAAAAAGTACTTTTTAAAGGCTGGGTGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGTTGGACCACCTGAGATCAGGAGTTCGAGACCAGCCTGACCAACATGATGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGCATGCGCCTGTAATCCCAGTTACTCAGGAGGCTGAGGCAGGAGTATCACTTGAACCCAGGAGGCAGAGGTTGCAGTGAGATGACATTGCGCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACCCTGTCTAAAAAAAAAAAGTACTTTAATCAACTGTAGTCTCAGGAAGCTGTCATTCTTGACCTTCCTACCAGTGAGCTGCTGGGGCTGAACGAGAAACCAATTTTTGAGAGTGTGGGTGTTCAGCCTGGGCACGCCTCTTCATAATTCCATCTGCCCCTGTGTGGATGTTACTGCATGAGTCTGTTAGTCTCAAATTCAGCAGTTTCAGGAGGGAAAACAAGAGTTGATACCAACTGTTGCCAGTGCAGCTGAGATGTCTGTCCATTTCAACCGCTGGTGTCGCCCCACCTCCCTACCCCCATCTGCCTAGGCTTTGAGGGCCATGCTCAGGACTCTTTTTTTTTTTTTTTTAGACAGAGTTTCACTCTTGTTGCCTAGGCTGGAGTGCAATGGCGCAATCTCGGCTCACTGCCTCCCAGGTTCAAGCAATTTTCCTGCCTCAGCCTCCCGAGTAGTTGGGATTACAGGCATCTGCCACCACACCCGGCTAATTTTTTGTATTTAGTAGAGACAGGGTTTCACCCTGTTGGTCAGGCTGGTCTTGAACTCTTGACCTCAGGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGCCATGTGCCACCATGCCCGGCGACATTTTTAATTTTTTATTTTTTATTTTTTTTTTTTTTTAATTAAGACACAGAGTCTCACTGTGTTGCCCAGATTGGCTTCAAACTCCTGGGCTCAAGTGATCCTCACACCTCAGCTTCCGCACACACCACCATGTCTAGGGGTCGCTGAGGACTATTTTTGGGGGGATGAGGTCTTAGTATGTTGCCCAGGTTGGCCTTGAACTCCTGAGCTCAAGTGATCCTCCTGCCTCAGCCTCCCAAGGTGTGGGGTTACAGGCAGGCGCCACTGTGCCTGGCCACTCAGGACTTTTGATTCCTCCAAGCTGAGTCCCAAGGCCGCTGCAGGGCTCAGAGCACCGGCCACCTGGGCATTTCCTTGGAAGCTAATGCTTTCTTCCCACTGACTGGCTCAAACATCTGGGTACAGGGTATGTTTTGGGGTACAGTAGGACAGGGATGAGACAGCAACTGCTCCTCCCTGAAATGCACAAGCCTGGAGCTGAGGGATGCCTGTTCCTGAGTGTCACCTGGAGTGTCCAGGTATCTTTTTATATCAGGAAGTGCAGTCAGTGAGTGCTGTGGGTCCCACCTGTGGGCCACCTGCCTTGATGTCAGGAACACCTCAGCCTTCTAGTCTCGGAGACAAACCAGCCAGTGGCAGGAAAGTAAACAGGATTTCGATTCTGCTCCATCTGTCCTCATCCCGTGACTAGGAATGGCCAAGTCTCAGCCCAGAGGAAACTGTTCATGGTCCTGATCCTGCACCCTGTGGTACCCACGGGCCGCCTCTTGAAGGGCAATCCCATGAGCCGGGGTCCTGGCGTGCTTCTCGATTTAACCCACAGTTCTCACATTTCCCTCTGGCTGAAGTCTGCAGCAGGCCTTATGGTAAAGACCAAACTTCCACAGAGCATTTAAAGCCTGGTGGGGCAGGACATGGTGGCTCACACTTATAATCCCAGTACTTTGGAATCGCTTGAGCCCAAGAGTATGAGACCAACCTGGGCAACACAGTAAGACCCTGTCTCTACAACAACAACAACGGCAAAGATTAAGTCTGGTGGGTATTGATGGAGCCTGGGCAGGCAGCTCGGGGCTTCCTCGAGTTGTTCCCCAGAGCCCTGCACAGCCTCGGGCAGACCCTTTTCTCCCGTTTTACAGATGGGCAGTGGGAAGCTCTAAGAGACAGGGGCCTCCCCAGGGCACACCAGTCACCCACAGCCAGGCTGCATGCCGCCCCACCCCGTACACTGTCCTCACTCATGAAAGGGACCCAGGGCCTGTCCCTCATGGCCGGCACTCATGGGCCCCACACACCCACCTGTGTCATCTGAACAATGACCATTCCTGGCCAGCGCAGGGTCTAGGATGCGCTATGTTCTCAGGGTCTGTCCCGGTGCCTTTCTGTTTTTGTTGATTGAAAAACTGTTTCTGGTGACTGATACATACTAACTGAAATCCCTTTCATCCAGTTCCCCTTATGAGGTTCAGAAGATTCAGTGTCTGGGGGCCTGACTTAGAACACAGGGCTTATCACTCACAGCAGCCTGAAAAGAACGTGGTCCTCCATGTAAACCTGGCATCACCGGATGCACTGCCAGCAGTCCCTGGTGAACCCCAGGAATGGCCTGTCGGAG endometrial cancer 29334253 Circular RNA expression in extracellular vesicles isolated from serum of patients with endometrial cancer. Xu H, Gong Z, Shen Y, Fang Y, Zhong S. Epigenomics. 2018 down RNA-seq, northern blots extracellular vesicles isolated from serum of patients with endometrial cancer hsa_circ_0109281 circRNA homo sapiens ZNF486 hsa_circ_0109281 TTGTGTGTTCTCATTTTGCCCAAGACCTTTGGCCAGAGCAGAGCATAAAAGATTCTTACCAAAAAGTGATACTGAGAAAATTTGAAAAATGTGGACATGGCAATTTACACTTTAAAAAAGGCTGTGAAAGTGTGGATGAGTGTAAGTTACACAAAAGAGGTTATAATGGACTTAACCAATGTTTGACAACTACCCAGAGCAAAATATTTCAATGTGGTAAATATGTGAAAGTCTTTCATCAATTTTCAAATTCAAAGAGACATAAAAGAAGACATACTGAAAAAAAACCTTTGAAATATATAGAAGGTGACAAAGCTTTTAACCAGTCCTCAACCCATACTACACATAAAAAAATTGATACTGGAGAGAAACCATACAAATGTGAAGAATGTGGCAAAGCCTTCAACCGGTCCTCACACCTTACTACACATAAGATAACTCATACTAGAGAGAAACCCTACAAATGTGAAGAATGTGGCAAAGTCTTTAAGTACTTCTCTAGCTTTACTACACATAAGAAAATTCATAGTGGAGAGAAACCCTACATTTGTGAAGAATGTGGCAAAGCCTTTATGTACCCCTATACCCTTACTACACATAAGATAATCCATACTGGAGAGCAACCCTACAAATGTAAAGAATGTGACAAAGCTTTTAACCATCCTGCAACTCTTTCTTCACATAAGAAAATTCATACTGGAGAGAAACCGTACACGTGTGATAAATGTGGCAAAGCCTTTATTTCATCCTCGATCCTTAGTAAACATGAGAAGATTCATACGGGAGAGAAACCCTACAAATGTGAAGAATGTGGCAAAGCCTTCACCCGCTCCTCACACCTTACTATGCATAAGATAATTCATACTGGAGAGAAACCATACAAATGTGAAGAATGTGGCAAAGCCTTTACATGGTCTGCAGGCCTCCATAAACATAGGAGAACTCATACTGGAGAGAAACCCTACAAATGTGAAGAATGTGGCAAAGCGTATACTACATCCTCAAATCTAACTGAACATAAGACAACTCATACTGGAGAGAAACCTTACAAATGTAAAGAATGTGGCAAAGCTTTTAACTGGTCCTCAGACCTTAATAAACATAAGAGAATTCATATTGGACAGAAACCAAGAACGTGACAAAGGATTATTTTATTATTATTATTTTTTTGAGAGGTAATTCTGCTGTTGTTTCCCAGGCTGGAGTGCAATGGCATAATTTTGGCTCACCACAACCTCCACCTTCTGGGTTCAAGTAACTCTCCTTAGTAGCTAGGATTACAGGGCTGCACCACCACACCTGGCTAATTTTGTATTTTTAGTAGAGATGGGGTTTCTCCATGTTGGTCAGGCTGGTCTCAATCTCCTAACCTCAGGTGGTCTGCCTGCTTTGGCCTCCCAAAGTGTTGGGGTTACAGGCATGAGCCACTGTGCCTGGCTGACAAAGCTTTTTAAGGAAGTTCTCAACCCTTATTACACATAATTCATACTGGACAGAAACCCTACAAGTGTGAAGAATGTGGCAAGCCTGTAACAAGTTCTCAATTCTTTTATTTTTATTTGTTTATTTATTTTTTGAGATGCAGTTTCACTCTTGTGACCCGGGCTGTAGTGCAATGGCATGATCTTGGCTTACTGTGACCTCTGCCTCCTGGGTTCAAGCCATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGTGCCACCACCATTCCCAGCTAATTTTTGTATTTTTAGTAGAGATGGGCTTTTGCCATATTTGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCACTCGCCTCGGCTTCCTAAAGTGCTGGGATGACAGGCATGAGCCTCAATTCCCAGCCATAAGCTCTTAATTCTTAAGAGACATGGCGATAATTCATGGTGAAGAGGAACTTTACAAACCTGAAAGATGTGACAGTGCTTTTCCCAACACCTCCAACTTTTCTATGCATAAAAAAAATTATACTACACCATAGAAATGTATGAAATGTGACAAAGCCTTTATATGGTTGCCACACTTTATTGTAGGTAATTCATACTTCCAAAATACCTACAAGTATGAAGAATGTGGCAAAACTTTTAATCAGTGCTTACACCGTATTTCACAGGAAAGCTATTATCCTTGAGAAAAATTGTACAAATATAAAGAATATGGAAAAGCCATTAATGTCCATCACATCTTACTCAACAGAAGAAGGTTCATAAAAGAGCAATTACTGTGACAAAAATCTTTCAGAAAATATAAGCCTTTAAGGTGAAGAAGAGTATTGATTCTGAAGACAAGCATTACAAATATAAAGAG endometrial cancer 29334253 Circular RNA expression in extracellular vesicles isolated from serum of patients with endometrial cancer. Xu H, Gong Z, Shen Y, Fang Y, Zhong S. Epigenomics. 2018 up RNA-seq, northern blots extracellular vesicles isolated from serum of patients with endometrial cancer hsa_circ_0109335 circRNA homo sapiens ZNF254 hsa_circ_0109335 GTATGTGTCCTCATTTTGCTCAAGACCTTTGGCCAGAGCAGGGCATGGAAGATTCTTTTCAAAAAGCAATACTGAGAAGATATGGAAAATATGGACATGAGAATTTACAGTTAAGAAAAGGCTGTAAAAGTGTGGATGAGTATAAGGTGAACAAAGAAGGTTATAATGGACTTAACCAGTGTTTCACAACTGCCCAGAGCAAAGTATTTCAATGTGATAAATATTTGAAAGTCTTCTATAAATTTTTAAATTCAAACAGACCTAAGATAAGACATACTGAAAAGAAATCTTTCAAATGTAAAAAACGTGTCAAATTATTTTGCATGCTTTCACATAAAACCCAACACAAAAGCATTTATCATAGAGAGAAGTCCTACAAATGTAAAGAATGTGGAAAAACCTTTAATTGGTCCTCAACCCTTACTAATCATAGGAAAATTTATACTGAAGAGAAACCTTACAAATGTGAAGAATATAACAAATCTCCTAAGCAACTCTCAACCCTTACTACACATGAAATAATTCATGCTGGAGAGAAACTCTACAAATGTGAAGAATGTGGTGAAGCTTTTAATCGATCCTCAAATCTTACTACACATAAGATAATTCATACTGGAGAGAAACCTTACAAGTGTGAAGAATGTGGCAAAGCATTTATCTGGTCCTCAACCCTTACTGAGCATAAGAAAATTCATACTAGAAAGAAACCCTACAAGTGTGAAGAATGTGGCAAAGCATTTATATGGTCCTCAACACTAACTAGACATAAGAGGATGCACACTGGAGAGAAACCCTACAAATGTGAAGAATGTGGCAAAGCTTTTAGCCAGTCCTCAACCCTTACTACACATAAGATAATTCATACTGGAGAGAAACGCTACAAATGCTTAGAATGTGGCAAAGCTTTTAAGCAACTCTCAACTCTTACTACACATAAAATAATTCATGTTGGAGAGAAACTCTACAAATGTGAAGAATGCGGCAAAGGTTTTAATCGATCTTCAAATCTTACTACACATAAGATAATTCATACTGGAGAGAAACCTTACAAGTGTGAAGAATGTGGCAAAGCATTTATCTGGTCCTCAACCCTTACTAAACATAAGAGAATTCATACTAGAGAGAAACCCTACAAATGTGAAGAATGTGGCAAGGCATTTATATGGTCCTCAACCCTAACTAGACATAAGAGGATGCACACTGGAGAGAAACCCTACAAATGTGAAGAATGTGGCAAATCTTTTAGCCAATCCTCAACCCTTACTACACATAAGATAATTCATACTGGAGAGAAACCCTACAAATGTGAAGAATGTGGCAAAGCCTTTAACTGGTCCTCAACTCTTACTAAACATAAGATAATTCATACTGAAGAGAAACCCTACAAATGTGAAAAATGTGGCAAAGCCTTTAAGCAGTCTTCAATCCTTACTAACCATAAGAGAATTCATACTGGAGAGAAACCCTATAAATGTGAAGAATGTGGCAAATCTTTTAACCGGTCTTCAACTTTTACTAAACATAAGGTAATTCATACTGGAGTAAAACCCTACAAATGTGAAGAATGTGGCAAAGCATTTTTCTGGTCCTCAACCCTAACTAAACATAAGAGAATTCATACTGGAGAGCAACCCTACAAATGGGAAAAATTTGGCAAAGCCTTTAATCGGTCCTCGCACCTCACCACAGATAAGATAACTCATTGGAGAGAAATCTTACAAGTATGAATAATGTGCCAAAGCCTAAGAAAACCCTCAATTCTTAATAGATATAAGATTATTCCTACTGGAGAGAAACTACAAACCTGAGAGAGGCGCTAATGCTTTTGACAGTACCTAAAACTTTAAAGAAAATCATTCTGCTGAAAAATCCTAGAAATGTGAAGAATGTGAAAAAGCCTTTAAATGATTGTCACACTTGATTGTAG endometrial cancer 29334253 Circular RNA expression in extracellular vesicles isolated from serum of patients with endometrial cancer. Xu H, Gong Z, Shen Y, Fang Y, Zhong S. Epigenomics. 2018 up RNA-seq, northern blots extracellular vesicles isolated from serum of patients with endometrial cancer hsa_circ_0112879 circRNA homo sapiens ZNF124 hsa_circ_0112879 AACTCGGTTGCCTTTGAGGATGTGGCTGTGAACTTCACCCAGGAGGAGTGGGCTTTGTTGGATCCTTCCCAGAAGAATCTCTATAGAGACGTGATGCAGGAAACCTTCAGGAATCTGGCTTCCATAGGAAACAAAGGGGAAGACCAGAGCATTGAAGATCAGTACAAAAATTCTTCAAGAAATCTAAGGCACATCATATCTCATTCTGGAAACAACCCATATGGGTGTGAGGAATGCGGAAAGAAGCCATGTACATGTAAACAATGTCAGAAAACTTCCCTTTCTGTCACAAGGGTTCACAGAGACACAGTAATGCACACTGGAAATGGACATTATGGTTGTACAATATGTGAGAAAGTTTTTAATATTCCCAGTTCATTTCAGATACATCAGAGAAATCACACTGGAGAGAAACCCTATGAATGTATGGAATGTGGGAAAGCCTTAGGTTTTTCCCGTTCTCTTAATAGACATAAAAGGATTCACACTGGAGAAAAACGCTATGAATGTAAGCAATGTGGGAAAGCCTTCAGTCGTTCCAGTCACCTTCGTGACCATGAAAGAACTCATACTGGAGAGAAACCCTATGAATGTAAGCACTGTGGGAAAGCCTTCCGTTACTCCAATTGCCTTCATTACCATGAAAGAACTCACACTGGAGAGAAACCTTATGTGTGCATGGAATGTGGCAAAGCTTTCAGTTGTCTCAGTTCCTTGCAAGGACATATAAAGGCTCATGCTGGTGAAGAACCCTATCCATGTAAGCAATGTGGGAAAGCCTTCAGATACGCCAGTTCCCTTCAGAAACACGAGAAAACTCATATTGCACAGAAACCCTATGTATGTAACAATTGTGGTAAAGGCTTCAGATGTTCCAGTTCCCTTCGTGACCATGAAAGGACTCATACTGGAGAGAAACCCTATGAATGTCAGAAATGTGGCAAAGCCTTTAGTCGTGCTAGTACCCTTTGGAAGCATAAAAAAACTCATACTGGAGAAAAGCCCTATAAATGTAAAAAAATGTAAAGGCTTTAATCACTACAGTTTTTGTCAAAAACATGAACAGTCACATACTTGAGAGAAACTGTGAATGTAAGGTGTAGGAAAGTACTTAATTTTCCCAGATTTCCTCAAATACATGAAACGAATCAAACTGGAGATAAACCCTATGACTATAAGCAATAAG endometrial cancer 29334253 Circular RNA expression in extracellular vesicles isolated from serum of patients with endometrial cancer. Xu H, Gong Z, Shen Y, Fang Y, Zhong S. Epigenomics. 2018 up RNA-seq, northern blots extracellular vesicles isolated from serum of patients with endometrial cancer hsa_circ_0113854 circRNA homo sapiens ATG4C hsa_circ_0113854 GAAGGAGATGGATAAGAAATACACTTGATAGAAGTTAAGAAGTAAAAGTGTCCTAACAAAAATCTGGAGCTGCCTCACAATCAATGCTATTAGAATGGTTGGTATACTTTCAAAGTATATGCCTGGAATACGATGACATTTTAGAAAGGGCTTGACTCTTAAGATAAATGTTACCTATATATTATAAATGTGTTTTTTATATATAAGTACACACACACACACACGTATACACAAGTACGCACACACATATACTAAGCAGTGTGTGTGTGTGTGTGTGTATGTAAATTGTTGCTTTCATGATTATTGAATGTGACATTCTGATTATTCTGGTTTTAATAGTTATTTTATTATACAACCTGAATTACTAATTAAAAAAATAAAGCACAAGAGTTAGAAACAGCTTACATTAAAACTACGCAGTATTCATGAAAAGGCAGTTTCGGGGCCTCGGTCATCACTGTGAATTTTTTTTTTTTTTGAGACAGAGTCATGCTCTGTCGCCCAGGCTGGAGTGCAGTGGTGTAATCTTGGATCACTGCAACCTCTGCCTCCCGGGTTCAAGCAATTCCCCTGCCTCAGTCTCCCGAGTAGCTGGGACTACAGGCGCACGCCACCACGCCTGGCTAATTTTTCTTGTATTTTTAGTAGAGACGGAGTTTCACCATGTTGTCCAGGCTGGTCTTGAACTCCTGATCTCAAGTGATCCACCCGCCTTGGACTCCCAAAGTACTGAGGTTACAGGCATGAGCTACTGCACCCAGCCTAGTCATCACTGTGAACTTCCACAAACACTCATTGAGAGCCAGTTACTCTGCACAAAGTACTGTGCATAGAGCTGGGAGGGGCACAGATGTTTAAGATGCGGATCCTGCCTTTAAGAAGGTATATTAGCTATTATAAGTTTCAATTAACCAAATGTGTGATGATTATTAAAAGTCAGTGTTACACATATTTACTTTGTTTTCTATTCTGATAAAGCTCATGTATGCTTTTAATTTCCCTTTAAATCTTAACTAATTTCCAAAACTATCAGTGTTTCATAAACAGCTTATAGTGCCCAGACAGAGAGCCTTGCCCTTAGTAGCACTCATCCTATTTTTGTTGAACTAAAACGAACAGCTTCTTCAGTTTTAACTCTTGCATGGTTGGCAATTGGCTGAATTGGAATGTGAAGACACATTTAGAGGAGAGAATGTTCTGTCTGAGTGCTGCAGCTGTAAGAATCTCTTCAAAAAACATAAAGTCTATTACATAAATTATGTACTCTTTAAACTCCCATGTTCATTTACACAATTGATCATGGAAACGACTTTAGAAATATGTGTATCAAATATTTAGCATATTTTTAAAGCTTCCTTAATAACATCACTAATAAGTGGATGCAATTTTGTGTTTATTTACGGCAAACACCTATGAATATCAGATAACCTAATTATAGTTTATCAACATTACCTTTGAATCATTCCAATGGAAATGTCCTCTCTCACTGCATTCATATTGTTTTGGTGCATGAGCATGGAAAACAGCAGATTATTTTCCATGATCATAGATTTTAAATATTTACTTGCTAGCGCTGCATAATTTAACGCACTAGAGTTGGAAAGCAGTTTGTATGACAGCTGATGCCATGTCAGTGTTGCAGAATATAGTTTCCTCCTGTGATTTCTGTGTGAAGTTGTAAAAAGGAAAGGTACTCTACTCCTTTTTTTCTAACCAATTAAAATTTGTTGTGGCAAATCTACAGAAAACCCAAGTCTGTAGTATACACACAATTTACTTTTGTATATATAGTTATTTTAAGAATCCAAGCATTGTTTCTCATGGCCTGTTAATGCACAATACCAAAAATAAAATACATGCATTCTTGTAATCCAGGTCTTTATGAAAGTTACAAAAAGGCATCTAAACAGCTTGTTAGATGCATGCTCTCTCTCCTAAAAAAAATCAAAACAGAGTTTGGGGATTTCGAAACAGGAAACCACAAGCTATGGAATCATGCAAGAAAACTACTTTGCTCACTCTAATAAGTGTGCCATTTGTGATCTTATCATATCCTTTGTTTGTTGTTTTGTTATTTAGCTGTCCAAGTACATGAATAAAAAATAAATAGATCCAGCTACCTGTTTCTGTGAGAATAAAAAAAAATTTAAACCACCAAATCCACTAAAAAATTGAAAAAATTTCAAGTTTAATTTTGAACTTTTCAACTCTTCATTCTTGAAGGTTTTCATTCCCATGTGGTTTCATAGTCCGGTGGCATAGACTTCATATTTTATTTTTAGTTTTTAGTATAATTTCCTATGTAATTCAGAAGCATGTCTGGTAGTCCTTGCTCCAACAAAATCTGCGGTACTGTAAAACGGCATAGGATTACATTTTACAGTAACAGTATTTCTCTTGACATCATTTAGGAGTGAAGATAAAAATTTCCACTTATTTATTTATTTATTTATTTATTTTTACTTTTTTGAGACAGGGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGAGGCACAATCTTGGCTCACTGAAAACTCCGCCTCCCGAGTTCAAGCGATTCTCCCGCCTCAGCCTCCTGAGTAGTTGGGACTACAGGCGCGCGCCACCGCACCCGGCTAATTTTTTATATTTTTAGTAGAGACGGGATTTCACCATGTTGGCCAGGCTGGTCTGGAACTCCTGGGCTCAAGTGATCCGCCCGCCTCGGCCTCCCAAAATGCTGGGATTACAGGCGTCAGCCGCCGCGCCTGGCCAAAAATTTCCACGTTATAAAAAGCATCTTCGGACCGTCCTTTTTTCTTTCTTTCTTTTTCTTTTCCTTCTTTTTTTTTTTTTTTTCCCCACAAAGCCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCGATCTCTGCTCACTGCAACCTTTGCCTCCCGGGTTCAAGCAATTCTCCTGCCTCAGGCTCCCGAGTAGCTGGAATTACAGGCGCCCGCCGCCACGCCCGGCTAATTTTTTAATTTTTTAACAGAGACGGGCTTTCACCATGTTGGCCAGGTTGGTCTCGAACTCCCAACCTCAAGCGATCCACCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGACGCGAACCACCGCGCCCGACTGTCCTGTGTTTTAATGCTTGAAAATAATCTGAATATGGAAAATGAGTGCACATATCCCTTGATGTTTTATAAATAACCTACAGTCCTAATAATGGCTTGGCTTAGAGTTCCTTCACAACAGGAAAAGAAGGCATCCTGGCTTTTTTTTTTTTTTTTTTTTTAAATCAAAGTGAGGCTTGGGTTGGCTCTATCTTGGTCCTGAGTGCGAGGAAGGAGGGCCGCAATGCATGCTGGATCTTGCAGTTCCTACGCCAGAGGCAAGGGCGTGATGCTGCATGGCCTGCTGGTAGTTGAAGTCCAAGTGCTCGAGAGGAATTTATGGCAGCCGTAATGTGGTTTGTCTATCAGAGAGACAATGCTCACAGACGGATACTTTCTCTTGGTTCTGCGCTTGCTGCATTGGTGGATTAGCGGCTTGGGGTGGCGAACAGGTGGGAAAAAGGGATGGATAAAGTAAGCATAGCAGAGGCCTTTACGCCGCTGCTATCGCTACTGCCAATCGCAAGGCTTTCGTATCCCGGAAGTGGCTGATCTGTTGGATTTGACGCGGAGGCGGTTCCTCTTACTACGGTGGCCGGGGTGCTCAAAGTACCTGTAGCTGCGGCGCTGAGGTCGGAACGTCTGCGTGTGTGCGGGCTGGTTTTGTGGCGGCTGCTGCTAGAGCTGGAGCATTTGCCGGGTTGGTGGCTCCTGCACATTTTTACAGTTCTCCAGTCCTTCTCTTTCGTCAGTATAAAAGATTAAACTCTACAGAAGAATGCAATCAAGTGATGGCTTTTCCTTTAGAATTTGAATATGGAGGCTACAGGAACAGATGAAGTTGACAAGCTAAAAACCAAATTTATATCTGCTTGGAACAACATGAAATATAGTTGGGTGTTGAAAACAAAGACGTATTTTAGTAGAAATTCTCCTGTATTATTGCTTGGAAAATGTTACCATTTTAAATATGAAG coronary artery disease 28045102 Peripheral blood circular RNA hsa_circ_0124644 can be used as a diagnostic biomarker of coronary artery disease. Zhao Z, Li X, Gao C, Jian D, Hao P, Rao L, Li M. Sci Rep. 2017 We verified the 5 candidate biomarkers by qPCR in another independent cohort consisting of 30 control subjects (CADS = 0, n = 30) and 30 CAD patients with different CADS (CADS 1¨C22, n = 10; CADS 23¨C32, n = 10; CADS > 33, n = 10). The results confirmed the findings of the microarray analysis, as the levels of these 5 circRNAs were significantly increased in the CAD patients; there was a 2.7-fold change in the expression of hsa_circ_0124644, and 2.2-, 2.1-, 2.0-, and 2.1-fold changes in the expression levels of hsa_circ_0082081, hsa_circ_0113854, hsa_circ_0098964 and hsa-circRNA5974-1,respectively. qRT-PCR, microarray peripheral blood from 12 CAD patients and 12 controls hsa_circ_0124636 circRNA homo sapiens ROBO2 hsa_circ_0124636 CTTGACATCTCTAAGAAAATATCTAGCATTGTGGCCTATACTACAATCTCCCAGATTTTACGCTTCTCACTTTTGTATACCCGGGGATTTGCATACTAGGACATTGGAAACTGCCAAAATGATAGACATGAAGCTCATCCTTTTGCTAGAAGAGATATAAGACAAAAATAGAAATAGAGAGGGGAAAGGAAGTGAATTGCAAAGTATATATTTCCATTTAAGACTCCTTTTTTCTTAAAGTTTCTGGCTTCAGGTTTAAGTACCTTTGATCTGAATCAGTCTCTCCCTTTTCCCAGCGCTCTGATGCATTGATACACTTGACAAGATCCATGCAACTTGAATGGAGGGGGAAAATCAAGAGATGAATATTTTGCAAATAAGCAGGTCAGCCGAAAAGCCTAAGAACAGACTCAGAGCACCCAAGGACTCATTCACATAGGGACCCCTTATTATCTTATAATCACAATATAAATACCTCGTTAGTCCCTCTCCATGTCAGGTGATTCCACCGAACCTGGGAGTGGCTGCTTCCCTTCTTCCCTTTCTCTATTACACGTTCCAATTAACCCTCAATGAGCTGCATCATTGGTCCTCATCGCATCAGAAGGATTTCCAGGCCAGGCGCAGTGGCTCATGCCTGTAATCCCAGCACTTTTGGAGGCCGAGGCAGGCGGATCACCTGAGGTCAGGGGTTCGATACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCCGGGCGTGGTGGCAGGCACATGTAATCCCAGTTACTTGGGAGGCTGAGGCAGGAGAATTGCTTGAACTTGGGAGGTGGAGGATGCAGTGAGCCGAGATTGTGCCACTGCACTCCAGCCTGGGTGACAGACCCAGACTCCATCTCAAAAAAAATTTCTAGTACTGTGATGATAAGTAGTATAGCATCCTATAAAGAGTAGTGGGCTGAGAATCAGAGTGCTTATAGTCACTGGATTTTACAGCTGGAAGGGATCTTACAAGTTATCTAGTCAAAATTCTCATTTTCCTCTGTAAGAAACTCAGGTCCAAATCAATAATGTGACCAATCTTTTAGTCCTGGTCTATACCACTGTGGGACCTTGGAGCCTCTAATTCTCATCAATCTCTGCTTTCTAAATGCAAAATTTGCATAAATCAAATAATGTCAAGAAACCTCTACATTATAGGATGCTAGTAGTCCACATCTTGACAAAACAAAACAAAACAAAACAAACATTTTAAAACATTTAAAAAGCACTTTTGAATTTTAAAAAGGGCCTTTCTGATTTTAGCGTCAGGCTTCAGAATGTAACCTTTCATATCTGGACTGTACGGTCTCTTAGATAGAGTGAGTTCCCAGTATACTATAGAAAACATTGAATTCTCTTCTTCATTTATTACTATTTTTTTCTTAAAGGTGCCTCTCATATTATTTGTCCAGAAGTTTGATATGAAAAAACAGTTGCAACAAAAATTGCTTCTTTTTTTTTTTTTTTTTTTTTTTGACAGGGTCTCCCTCTGTCATTCAGGCTGGAGTGCAGCGGTGTGCTCTCAACTCACCGCAACCTTTGCCTTTCGGGTTCAAGCAATTCTCCCACCTCAGCCTACCAAGTAGTTGGGACTACAGGCATGCGTCACCACGCTTGGCTAATTTTTGTATTTTTAGTACAGATGGGGATTTGCCATGTTGGCCAAGCTGGTCTCAAACTCCTAGACCCAAGTGATCCGCCCGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCGCCTGGCCCAACAACAATTGCTCTCTGCATGGTGTGATTCCAGTGGAGGTCCTAGTCAGTAGGTCATTCCAGGTAGTCATTGTTGCCAACCATTGACAAGGCCCAAGGAGAACAGCAGAGATGCGGGAGGTAGGGCAGGAATAGGGGAAGCAAGTTTTGAAAACAGATTTATCTGGGTCCAAATTTGAAATATTTTATTTACTAAATATCATGTTTAAGATAAGCTCATCAAACTCTGCAAGCCTCAACTTTCTCAGTGGAAAAACAGCAATGCCTATATTGTTCTGTTAAATATGGGTTAAATAATGGTGAAGTCTCTATAGAGAACCACCATATTCATTGCAAAGTAAAGGCTGGAAAACTCTAGCTTAATATATGTATTTTCTTTTGTTCCTTGCCTTGTCTGCACTTCTTTTTGGAATTGACCTTCAGAAGTATATGTTCTTTCTAAGTTTGTATTATTCTTATAGAGTTATTATAAATATGGTATTTGTATATTAAATATAACTCAATTTCAAGTTTTTTATATATAAACTAGGAAAGGTGATCAATGTTTATAAGCCACGTGGCAATATATTTCACTCTGACTATATGTGCATCTATATGTGGCTTGAAGTTAGCTGTTTGAGTGATCAAATCAGAATAAATAAATCAACTTGATTTATGTTTTTGTTTTTCAAGAATTTTGTGTAATCCTTCATCTAAATTAAAGAAATTGACTAGTTTGGTAATAATACAGACAACGCTGTAAGAATAGCATTTGCATTGTGGGCGGTATGCAAAAAAATGTTTTTCCCTCT type 2 diabetes mellitus 27878383 Hsa_circ_0054633 in peripheral blood can be used as a diagnostic biomarker of pre-diabetes and type 2 diabetes mellitus. Zhao Z, Li X, Jian D, Hao P, Rao L, Li M. Acta Diabetol. 2017 The levels of hsa_circ_0124636 expression among the three groups presented no significant differences. qRT-PCR, microarray peripheral blood of T2DM, pre-diabetes and control groups hsa_circ_0124644 circRNA homo sapiens ROBO2 hsa_circ_0124644 GGAAGGAAAAGCTTCTTCAGAATCTCCAGAAGATTTTCACTTGTATCTCACCGGCCAGAACTGTGTCACATATCAACACATACCTGTGAATGGAGCTGGAAAAGCACGTATTACTTGGACACATTATTGTCAGAACACAGGAAGGATTATGATGCCATAGAAAAGGGGTGAGTGGTTATTTAGTAGGAACTTCAGGGGCTGGACAGGAGATTTGAAGCAGGAAAGTGAGTTCAGCAATGTTATATGCCATAGTGCTCATTACATCATCTGGATTTTCCAGAGCCAGGGTAATTAGTTTTCAGATTAAAATTAGTTTTCAGATTATTTCTTTAAAATGAAGTATATTTGCAAAAATAAAATCATTAAATAGTAAAAAATGTCAATACTGAAAGAGACCTGCTGTTAGAGGCCACACTGTCTATTGCAATGTGGGGCTGCCTCTCAGCCAATGAGAAGTATAACCAGACCACTTCCTTCTGCCAACAGCTCTTCTGAGGACATGGGATAGCAAAGGCTGCAGATCTCAACACAACTTTAGAGGTAGGATTTTGAGGATAAAGAAAACAAGTAAAGAAAGGGGAGGGAGAGAGACACGTGGAGAGAAAGAGACATGGAGAGAGAGGACTAAGGAAAGTGGCTGAGGCCTGCCCCTCTTCCAAACACTTGTCCTTTTCTTTTTCTTTTCTTTTTTTTTTTGAGATAGAGTCTCACTCTGTCGCGCCAAGCTGGAGTGCAGTGGCACAATCTCAGCTCACTGCAACCTCTGCCTCCTTGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTAGAGGTCCGCACCACCCTGCCAAGCTTATTTTTGTATTTTTAGCAGACACGGGGTTTCACCATGTTGGCCAGGATGGTCTTGATCCCTTGACCTTGTGATCCTCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACTGCGTCCAGCATGTCCTATTCTCATATTCAGAAAAAGGCTAGGCTCAGCTAAGAAAAGATAAGAAGACATTATTTAAACTAGTAGTAATTTGTTTGGCCAATTTCCAAGTTAATTACTACTTGACCCTACTGAAAACTGCCTTTTGGATTTGGTTATAGAATGCCTTGGAGTTATGGAGACAGAAGTCAGAATACAGCAGGTTGAGAAGTAACTCGTCAAG coronary artery disease 28045102 Peripheral blood circular RNA hsa_circ_0124644 can be used as a diagnostic biomarker of coronary artery disease. Zhao Z, Li X, Gao C, Jian D, Hao P, Rao L, Li M. Sci Rep. 2017 We verified the 5 candidate biomarkers by qPCR in another independent cohort consisting of 30 control subjects (CADS = 0, n = 30) and 30 CAD patients with different CADS (CADS 1¨C22, n = 10; CADS 23¨C32, n = 10; CADS > 33, n = 10). The results confirmed the findings of the microarray analysis, as the levels of these 5 circRNAs were significantly increased in the CAD patients; there was a 2.7-fold change in the expression of hsa_circ_0124644, and 2.2-, 2.1-, 2.0-, and 2.1-fold changes in the expression levels of hsa_circ_0082081, hsa_circ_0113854, hsa_circ_0098964 and hsa-circRNA5974-1,respectively. hsa_circ_0124644 can be used as a diagnostic biomarker of CAD. qRT-PCR, microarray peripheral blood from 12 CAD patients and 12 controls hsa_circ_0126408 circRNA homo sapiens TCONS_00008058 hsa_circ_0126408 AATGCATGTCTTCCTACTAGATTGTAAGCTTGTCGGGGCCACATCTATCCTGTTTACTACTGAATCCCAGCTGGCAGAAAGTAGTCATTTCACAATATTTTTGGAGCAAATGCATCAATCAGACCATCATGTGTAAGGGAGGTCACAGGATGAAGGAACAGTGCAGTGACCTGGAACACCATGCCACGCTGCTGCAACTGTGTCGGTCCGTGGCTGTGTGTGCGTGCTCTGCACCCCTAGATGAACTCACCAAACAGCATCTACGGAAAAGCCCATGAACTGTTGCTGCGAAGCAAAGGTGATTAAATGTAAGGTTATAACAATAGTGAGTGTTTCTCGTGTCATCAAGCATATTTTGTTTGTATTTTAAAGGTGATTGAAGTGCAAAATTACAGCTAGGCATGGTGGCTCACGCCTGTAATCCCAACATTTTGGGAGGCCGAGGCAGGCAGATCACGAGGTCAGGATATCGAGACCATCCTGGCTAACACGGTGAAACCCTGTCTCTACTAAAAAATACAAAAAAATTAGCCGGGCATGGTAGCGGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCATGAACCCGGGAGGTGGATCTTGCAGTGAGCTGAGATCGCACCACTGCAGTCCAGCCTGGGCGACAGAGTAAGACCCCGTCTCAAAAAAAAAAAAAAAAAATTAGCCAGGCGTGGTGGCACGTGCCTGTAGTCCCAGCTACTTGGGAGGCTAAGGCATGAGAATCACTTGAGCCCAGGAGGCGGAGGTTGCAGTGAGCTGAGATCACTCCAATGCACTCCAGCTTGGACGACAGAGTGAGACTCCGTCTCAAAAAAAAATAAATAAATAAAAGAAGTACAAAATTACTTAAAATCTGATTTGTTGCAAAATGAATACAGGTACTAGAAAAGGAGCCTCTTCATGAGACTATTTAATGGAGTATGTCTCCTTGAGGAGCCATCACAATCTGCAGGCAAGTTTGTGTACCTACATCAGTAAGAAAAGCTTTGCTTATTGCAAGAAATCTTATTTCTTCAGCCTTTGTCCAATTGTGTGTAACCACAGGCTCATTCTTATTATACAGATGCAGGACGGTTGAGTATGTGTGATTCTACATCATAATTATATAACCTAAGTGTTTACAATTTTTTTGGTAAATATTTTGCATTTTGTGGGCTATGTTGAGTATGTTTCACAACTAGTCAGCTCCACCACTGTAGTCCCACAGTATCCGTAGACAATACTTAAACAAATGAGCATGGCTGTTGTATTGATTTTATTGCTGTATAGTAAGTTACCACAAACTTAGTGGCTTAAAACAACATCCACTTATCTCACAGTTTCCATGGCCAAGAGTCAGTTTAGCTGAGTCCTCTACTCAGGGTCTCTCAAGTCTGTAGTCAAGGTGTCAGTAAGGGCTGCAGTCTCATCTGATGTTTGTGATCCTCTTCCAAACTCCAGGGCTTACTGCAGAATTTATTTCCTTGCAGCTGGTTAACTTGTGATACCTTGCTTCTTTATAACCCTCAGGAGAGCACACCTCAGCAGGAGGCTCAGATAGGTCCCAGCCGCCCATCTTTTACGGGCTCACCTGATTAGGTCAGGCCCACTCAGAATTATTTTTCTTTGGTTACTCAAAATCAACTGGTTATGAACTTTAATTCTATCTGCAAAATCTTGTCACCTTTGCTATAAAAAGTAACATAATCACGGGAGTGACACCCCATCATATTCTCAGTCCCACCCACACTTGAGTAGAGGAGAGATTATACAGAGTGTCTATACCAGGCCATGGGAATATTGGGGCTACCTTAGAATTCTGTCTGCCACATCGGTGTTCAAATAAAACAACAAATGGATACTGAAATGTGAATAGCAGATAATTTTTCACCTGTCACAAAACTATTTTCTTGTTTTGATTATTTTCCAATTATTTTAAAATGTTATAACCATTCTTAATTTGCGGGCTTGGGGAAAAAAAACAACAAACCATGCACTAGGCTGTATTTTAATTGTGGGCTGTAGTTTGCCATCCCCTGATATAACCTGAAAAATGGAAGAAGATAGCCCAGATTGCCTGGTAAGAAGTAGGTCCCATAACCAGATGTTAGATCCAGATGACATGGCTCTGCAACGTGGGAGCAATGCTGAAGTTTAAGGATAGCTTCTCTTGCAAGTTGCTTCCTGTGACCTGGCAGGATTTAACCTTGAATAGACAGGAGACCAAGGTCACTGACCTAAAGGCATCTCCTGTATGAGGACATGGGGACATCTAGGAAGCTGTTCTCACCAAACATACCCCAGCTGGAAAGCCCCCAGATGCTTTCTGAAGTTGTCATCTTTGTGCTTATTGATGCAAGCTGCAGCTTCTTTGCATTTATTTGTTCCAGTGCTTATTTTCTTCAAGCCTACAAACGAATCCTCTATGGGGCTGTGCAACTTCAAATAGTCAATCAAAGATGAGAATGTTCTTTAGTTTTACTGGAAATGTAATTCTGCAGAAACAGAATTTAGGAACAACCATTAAGAGCAACCATTGCTTTTCATATCACAAGGTACAATCATAATTTCAGATATTTGTATTGTACATCCAGGCTAATTTTCATATTATTTAAATCAAAATTTTCGACAGCACAAATAAAAAGATTAACAACAGTGAAAAACATCCTTGTTCCAGGAGCGCAAAAAATCCTTAATACTATTGTGTGTAACATTAGATATTAGAATCATAATATATTTGTCTAGCCACAAATGTATTTGAACAATGTTAAAATGATGCTTGCGGCATGTATTTCTTCCTAAGGCTTCTGTTTAAGAAAGTCTGGGCTGGGCGCAGTGGCTCACGCCTGTAATCCCAGTACTTTGGGAGGCTGAGGCGCGTGGATCACCTGAGGCCAGGAGTTCGAGACCAACCTGGCCAACATGGAGAAACACCATCTCTACTAAAAATACAAAAATTAGCCAGGTGTGGTGGCGGTCGCCGTAATCCTAGCTACTCGGGAGACTGAGGCAGGAGAATCACTTGAACCTAGGAGGCAGAGGCTGCAGTGAGCCAAGATTGCGCCATTGCACTCCAGCCTGGGCAACAAGAGCGAAACTCTGTCTCAAAAAAAAAAAAAAAAAATGGTGCTTGTCTATCTGACAGGCACAATACAAATATTAATTTGTTCAAACCTTATAATAGCCTTTTAAAGACAGCATTATTATATATCATCCTTGATAAGAAAACTGAGACGCTGAGCACAGTTGGCCAATATCTCCTGACTAATAACTGACTGAACTGGGATTTGAACCCCACCTATTTCATTCCAGATTCTGTGTTCTCAACCACTATCCTCTGCTACCTCTCCAGTATATACTACTAATAAAAATATTTTCTGAATATGCTGACATAGTTTATGATATACAAATAATAAGATATTTTTAATGAAAACACGGAAATTAAAAATTCTTGAAGGTGACATCCCTCCAGGTGACTAACGTGCCCAATTAAATGACCATCTTTCCACTCGTCTAAGCCTCAGCAGGCTTGCGGATTATCTTGTCAGTGTGTCATCCAATATTTCTTTTTTTTTTTTCATCCAGTATTTCTAATGCTAGCTTTGAGAGTCTTTTCCAATAATGGCAATATCAGAATCTTGGTAGGGATCAGTTGCATGGTACAGATTTGCACAATTGTATTAATAATTCATCAGATTTTTTCAATTGATGTAGAAGATGTTATTGTAAAATTATTCAAAATTTGTTACATTTCTATAATATGAGTGAAGACACTGAAATAATCCTGCGATGTTATCAAAGACAAATTTGGTCCTATTCAAACATAAGATTTCTGATACAGATGCCTGTTCTCAGAAGAATACTAATAATGTTTCGACCATCACATGCTTAGTTTTTATCAGCTGAAAAAGTTGATTGTCAAGACATTTTCCAATGACATTAAATCAAAACAATGCCATTGCAATTTTCCATGACACTTTTTCCAAAATGGAGGGACAGAATATTTCTCCATGTGAATCTTTGCATTTTAATCAGAATTGAGGAGAAAGATAAAAATGTGAATGGTTTCACTCTAAAAATAAAATAATTTTTTAGAATACAATTGCTAATAATGTTAAATATTCATTGTGATGTAGATTTAGTGAAACTAATAAAGGGGATGGGAATTGAATTACCTACCTGTAGAGGCATATATTGAAAAGTCTTTAACAGTTTTGCTTTATTTGAAACAAACAAGCCAACAAACAAAGATTTGTTAAAAGGCTGTGAAAAGGATGATCTGAAGAAGGCCTGGAATCATTTCTAGGATATTTTATTTTCTGTTGTTATGGAGACTTTTAAAAACAAAATTCTTATTATTTAAATATTTGCTTACCAAGTCAAAGCAGAAGAAAACAAAATCCTCTATAAAGATTTTCATGAAAAAATATGTTACTATTCCAATATTTCATACCACCTGGTATGACTGATTTATCGGATCATTTTTACTAACAACTTTTGGGGATTACTAAAGAAATTGATACAAAATCTCACTCAATAATCCAAATGAATTACTCAAACTTTCCAAGACATGCTTGGAAAAAATAAAGAACAAATTCTCAATTTATAAATTGAATTCTACAAATGAACACAAAAGTGGAACACCCTGCCATCTGCTTCAACAAGAATGATGAAAATGACAAGACAAAAATTGCATCAACCCCTCTGTAATTTTTGGCAGAATTTTGTACTTATTCTCATGTACCTATATTCTTGTCAATAAAAGGTGATGGTCGAATGTATAACTCATAAAATTTGATTTTGTAATTTTTGAGGCTTTCTAAAAATAAATTCACAAATTAAAAGTATAACTTGTCAGAACATGAAGTCAAATTTGGGCTCTAGAAATACGGTCACCATATGAGTGTTCTGGATCAGAAAGAGCACTCTAAGTCAGAAAGGGTGAAGCAAAGACAGTCACAGTGGATGTAAATGAAAGAAAAATGAGGTGTGGGTGATTTGAGGATTAATGGGGGCTTTTTCTGTCCAGAAGAAATGCATTGCAGACATAAGATGATTCTTGATAAGGTAATAATCGCTTACTATAGTCAAACTCTAAGTACTTCAGCCAGAAACTACTGAGCACCAGGAGAGAGCTATTAGGCATTGTTAAAGCAATTGATCGCTTCCATCATTATTTGTGTGGCTGGAATTTCACAATCAGAACTTATCATGCTGCATTATGAGGCTTGCTGAAATTCACAGATTTGTAGGGACAAATTGGCTGGATGTTTACAAAACTGTAAGGCTATCATTTGCGAATTGAACATCGACAGAGAGTAAAAAAACATCGTAATGCCCATACATTATCTAGGCACCCTGTGTTGGGATAATGCTTGTGAAGCTGACATTAGGCATGAAGAAAAGAAACAAATAGTCTAACAGATCTGGTAGTTAGTGTTTTGGAACAACCAAAGGTTTCTGGCTGGGAGAGTGGAAAACACTCTTATTTCCTGAATAGAAAGTTATGAAATGGTTCATTCATCCACAAATATTTGTTGAGTGTATGCTATGTGCCAGGCACTGTCGAGGTATGAAGAATATACTAGCAAACAAGACAAATCGCAGAGCTGAGGTCCAGCAAAGGCCCAGAGAGAAAAAATATTATTTTGTGACAGTTGGATTGACTATACGTAAAAAACACCCATAAATTTTATGAAGAAGAGATGTCTAATAATATTGCCACTATTAAATACCATCATGTGTCATGTAAATATAGTCAAACTTTAAATTTCTTTTGCATGAAAGTGGTATCTAATTGACTGAGTGTGCTTTTTTTTTGTTTGTTTGTTTGTTTGTTTTAAGACGGAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCGATCTCGGCTCACTGCAAGCTCTGCCTCCTGGGGTTCATGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTATAGGCGCCCGCCACCACGCCCGGCTAATTTTTTTGTATTTTTTTAGTAGAGACGGGGTTTCACCGAGTTAGCCAGGATGGTCTCAATTTCCTGACCTCGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCTGCCAAGTGTGCTTCTTTTAAAAAATGTAATATTTAACCTTTGCACATTCCCAGAAGTTTGTTCACTTAGTTTTTCAAGAAAATTTAGGTTCGGCTGGGCGCGGTGGCTCACGCCAGTAATCCCAGCACTTTGGGAGGCGAAGGCGGGCGGATCACAAGGTCAAGAGATAGAGACCATCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGCAGGCCCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGCGAATCCCTTGAACCAGGAGATGGAGGTTGCAGGGAGCCGAGATCACGCCACTGCACTCCAGCCTGGCAACAGAGTGAGACTCCATCTCAAAAAAAAAGAAAGAAAAAGAAAATTTAGTTCCTTATACATGGTCAACCAAATTAAAATTGATTTGCAAAAAGGTGGATTTAACATATACAACCTAGAGAAATTCCAACTTTGAGGAAAACACAAGGAAGCTCTATAGTTCTACTTGATACCTTCTTATAGTTAAAAGTGTTTCCAAGGAATTCACAATTTTTAAAAATATAGTTCTGGCTTTTTTTGTTGTTTGGGGGTTTTTTGTTTTGTTTTGTTTTGAGACAGGGTCTCACTTTGTCACCCAGGTTGGAGTGTAGTGGCGTGAATATGGCTCATTATAGCCTGACCTTCCGGGCTCAAGAGATCCTCCCACCTCAGCCTCCCAAGTAGCTGGGACTACAGGCGCACACCACCACATTTGGCTGTATTTATTTATTTATTTATTTATTTATTTATTTATTTATTTATTTTGCAGAGACGGGGTTTTGCCATGTTGCCCAGGCTGGTCTTGAACTCCTGAGCTCAACTGATGCACTGACCTTGGCCTCCCAAAGAGCTGGAATTAAAAGCGTGAGCCACCACACGAACCTATATTTCTAATGTACTGAACTCTAGATGTTGGCATTATTTCTCAGATGCACCCAGAAAATGTTCTGATAGTCTAAACAGAACTAACCCTGAAAAGCAAATAAAAATTTCTAAGCACTTCACGCAGTGCTTGGCACATAATAAGTACTTATTAAGTATTTGTAGACATGATCAAGCAAATTGGATATGACAAATTGGCATCACAATAACTAGGTAGTAGGGGCAGATCCAGTTTTGTGGAACCTGAAGCTTATAAAATTGGAAGCCCCCTTTGAAAAAGGAATACAAAATCATCCACATGAAATTAGGCATGAGGCCGGGCCCAATGGCTCATGCCTGTAATCCCAGCACTTTGGGAGTCTGAAGCAGGAGGATTGCTTGAGTCCAGGAGTCTGTGGCCAGCCTGAGCAACATAGCAAGACCCTGTTCTCTACAAAAATAAAAGTAAAAAAATTAGCCAGGCATGGTGGCACATGCCTCTAGTCCTACCCACTTGAGAGGCTGAGATGGGAGGATTGCCTGAGCCTAAAAGTTTGAGGCCACAGGGAGCTATGATTGTGCCACTGCACTCCAGCCTAGGTGACATAAGGATACCCAGTCCCTAAAAAAATAAATAAGTAAAATAAAATAGAATTGGCATGAAACTGAATATTTAGAATGAGAAAATAAATCACTATAAATTATATTTTTTCCAGCTTTATTTGAAGTACAACTGACAAATAAAAATTGAATGAATCTATTTACTGTATAGAACATGATGCGTTGATATGTGTATATGCTGTGTGTATGTCACCCTCTTCTGCCTAAAGCATACCTTCTCCCCCTTCATCTAACCAATCATTCATCTTTCAAAATGCTCCTCATCTATCACCTCTTCAAGGAAGCCTTTCCTGACACCCCCAAAGTCTGGGCTAGGTCCCACCATGTGTGCTCCCAAGATATCACCTCTACCATGACACTTACCCTACTGCACTGAAACTGGCTGTCTACTCATCATCTGAATTCCCAACAGCTGAAGCATCTTAAAGAAAAGACCTGTGTCTTTTATCTTTATATTTCAGCGCCTAGTGCCCAGTAAACATACAATAGCTATTTGTTGAATGAATAAATGAGATTTATTGACTTTTTTTGGCATCAAACGAGTCCAGACCCTAGTGATCTCAAATCCATCATCATACTCTGCACAAACTGATTGAATATTGATCCCTTGCCATTGCTTCAAGTTAAAAAAAAAAAAAAACCTTTTGAAAATATGATGTGCAGGGCTGGGAGCGGTGGCTCCCGCCTGTAATCCCAGCACTTTGGGAGGCAGAGGTGGGCGGATTGCCTGAGCTCAGGAGTTCGAGACCAGCCTGGGCAACATGGTCAAACCCTATCTCTACTAAAACACAAAAAATTAGCCAGGTGTGGCAGCGTGTGCCTGTAGTCCCAGTTACTTGGGAGGCTGAGGCAGGAGAATTGCTTGAACCCAGGAGGCGGAGGTTGCAGTGAGCCGAGAAAAAAAAAAGAAAAGAAAATATGATGTGCAGCTATAAAACAACAAAACTGATTCTATAAGACATACATAAATACCAGGTTCATTATTTTATGATCATCCTTCACAAATAACAATTTGAAATGACTGAGTTGCAGTCAGACTTGAACACATACTTGTTATGAAGAATTATAACTTCATTTCCTACTATAAAACTAATTGTTGCCATTGAAAATGTTGGAAAGAAACAGGCTGGTCTAGAGAAGACTTACAAAAAAATATTCGATTTCATTTCTGTTAAAACTTTACCTGATTTTTTCCTATGTCTTAGTCTCCATGTTCTGTTTTTCAGTTCTGTTTTTCAGTGGACTCCATATCTGTGTCATCCAAGACGCCTACTGTTGACATAAAGCTGCTGCATAC endometrial cancer 29334253 Circular RNA expression in extracellular vesicles isolated from serum of patients with endometrial cancer. Xu H, Gong Z, Shen Y, Fang Y, Zhong S. Epigenomics. 2018 up RNA-seq, northern blots extracellular vesicles isolated from serum of patients with endometrial cancer hsa_circ_0131471 circRNA homo sapiens LINC00340 hsa_circ_0131471 GAATTGGCAACAAGCTCATTTCACTGGTGGGTTTGCTGAAGCATTATCACAAGACAGTCAGAATGACTGATGAGTGCTCTTCAGGTAGGGAAATGCTGCCAGCCTGGTTTGTATTTTGTCTTACCAAGAGTTTTGCTCCTTAATTTTCTATTTCAGTTATGAATAATCCCTTTTCATGCTAGTAGCCATAATCACATTATAAAGGATTTAAAATTTGTCATTTCCTGGTAGTATTTCTTACAGCGTAAGCATTTTTGGTTCATGTACGATTATTCTCCTTTTATTTTATTTTTTAACATGAGGAGATATCATAGGCCAATATTAAGATTTCCTAATTTTAATGTTAAGAGCTAAGCACATATTCTGGTCAAGTAGAGAAGTTAAAGAGTGACCAGACTTTATCTGAAATGGTAGGAATAGGAGACATGCTGTTCCATGATGTACCTTGACACGGTTTTTAAAAAGCAACATTTATGCCTGAGAATCTAATGAGTTTGGTTAAAAGGAGATCTAGTAAGCCAATATTCATTCATTTCTGCCTCTCCCCCTAGATTCCTCCAATCATGTTTGTTTCTGTGTCTTCTTTTTTTTTTTTTTTTGAGATGGAGTCTCGCTCTGTTGTCCAGGCTGGAGTGCAGTGGCGCGATCTCGGCTCACTGCAAGCTCCACCTCCTGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCTCCTGCCACCATGTGTGGCTAATTTTTTTTTGTATTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTAACCTTGTGATCCACCCGCCTCGGCTTCCCAGAGTGCTGGGATTACAGGTGTGAGCCACTGTGCCCAGACCTGTTTCTGTGTCTTCTTAAATTTAGAGACCGTTAGCTTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGAGAGATGGAGTCTCACTAGGTTGCCCAGGCTGGAGTGCAGTGCCTATTCACGGGTGTGATTATGGCACTCTACAACCTTGACCTTCTGGCCTCAAGTGATCTTCCCTCCTCAGCCTCCTGAGTAGCTGGGATTACCAGTGTGTGCTACCATGCTCAGCAATCTTTAAATTTTTTTGGTAGCTATTTTTTTTTTTTTTTGAGACAGAGTCTCACTGTGTTGCCCAGGCTGGAGTGCAGTGGCGTGATCTTGGCCCACTGCAACCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGTCTCCCAAGTAGCTGGGACTATAGGTGCCTGCTACCATGCCCAGCTAATTTTTTTTTTGTATTTTTAGTAGAGATGAGGTTTCACTATATTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCTCACCTCGGCCTCCTAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCGGCCTTGGTAGCCATTCTTGTAGAGCACTACACATCTGTCTCTGACTGAACAGGCCCAGAGATGTGGACAAGTTGGTCTCATAGAAACTTATTTTCAAGTTCGTCATGTGAGAAGCCCAAGGGAGTGGAGGACAGCCGTATATCTGGAAAGTGAAAACACGTAGCTGTACTTTTTGGGCAAACATAAAACTACATTTGAATATAGTAAATTCTTAGATAACTGTGAGCCATGGCCAACCAAAAGCATGGCACATACAAGGAACATGTGCCGGGTGGACCTTGAATGATCACATTTAACTTTGTGTCTGTAGAACTTGTGTTTCATTTTATTTTTCCCTTCCAAAGTTGTTTTTTGTTTGTTTGTTTGTTTTGTTTTTTTTGAGACAGAGTTTTGCTCTTGTCATCCAGGCTGGAGTGCAGTGGTACAACCTCAGCTCACTGCAGCCTCCACTTGCCAGGTTCAAGTGATTCTCCTGCCTCAGCGTCCCAAGTAGCTGGGATTACAGATACGTGCCACCACGCCTGGCTAATATGTTTGTATTTTTAGTAAAGATGGAGTTTCACTGTGTTGGCCAGCCTGGTCTCGAACTCCTAACCTCAGTTGATCCCCCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGTGCCCAGCCCCTCTCAAAGTATTTTGAGTGGAACATTGTTCATAGAAGAAGTTACATCTTTTCTGGGGTTAGGATGTACATTTCATTAGGTCCTTCCAGATACTTAAAAGGTTCTCCGCATGCTGGTAGAATATGTGGTAATTCTCAGTTGATGAATTATATGATTGTGGCAGTTTGAATACGTAGATATTATAGATGTTGTAAATGGTTTTGTCAGGCAGAGTGAGCTACTATTTTAAACTAGCAAGAATATTCACTTTAACAGGCAGTTTCTTATTGGTGGCTAAGGCTGTTACAGCTATGTCAGTACTTTTTAGAAAAGATAAGCTGAAAGTATTACTCATTTATATTTATAAATCTAATCCTATGCATAACCAATGTTGAGCATTCCAAGCATTAATCCCGTGGTACTTGGCGTATAAAGGCCATGTGGAGCTAGACCTGGAAACACACCGTATACTCATCTCTTTTTGAATCTATGGGTATTTTTCCCCCTTTGGGAGTTCATTTTTCCTGGTTGTTCTGGGGGCTCACTGAGATGTAAGAGTTTCAGATTCTGGTTTCTTTGCGGAAAGACAGCAGAGTTCAAATTAGGCTCATAGACATTCTTGCCTAGTTGCCAATAATTCCTTACACAGTGACGATGGAGGTAAAAGAACACTGAGCAAGCCAAGAGCAGGGAGGGGAAGAGAGGAATCTCAAAGAATTCAGATGGGCCTACAAGGCAATTAATGTCAATACATTTCCTGTTTCCCACAACTTGGTTAGAGGTGGAGCTTGCAGTGACCTGAGATCGCGCTACTGTCCTCTAGCCCGGGAGACAGAGTGAGACTCTGTCCCCCAACAAAAAAAGTACAATTTTTGGCCAGGCGCGGTGGCTCACGCCTACAATCCCAGCACTTTGGGAGGCCGAGACGGGCAGATCACCCGAGGTCGGGAGTTCGAGACCAGCCTGACCAACATGGAGAAACCCTGTCTCTACTAAAAATACAAAATTAGCCTGGCGTAGTGGCACATACCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTATAACCCGGGAGGCGGAGGTTGCAGTGAGCCGAGATCGTGCCATTGCACTCCAGCCTGGGCAATAAGAGTGAAACTCAGTCTGAAAAAAATTAAAATAAAAAGTACAATTTTTATACTAACGATGGCTATGTTATATATATATATATATATTTATATAATTTTTTTAGACGGAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGTAATGGCACGTTCTCAGCTCACTGAAACCTCTGCCTCCCGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCATACGCCACCACGCCCGGCTAATTTTGTATTTTTTAGTAGAGACGGGGTTTCTACATGTTGGTCAGGCTGGTCGCGAACTCTCAACCTTGGGTGATCCGCCCGCCTTGGCCTCCCAGAGTGCTGGGATTACAGGCGTGAGCCACTGTGCCCGGCCTTTTTAAAAAAACTTTTTTTTAGATGGAGTTTCACTCTTGTTGCTCAGGAGTTGCACCTGGAGTGCAGTGGTGCAATCTCGGCTCACTGCAACCTCTGTCTCCTGGGTTCAAGTGATTCTCCTGTTTCAGCCTCCTGAGTAGCTGGGATGATAGGAGCATGCCACCACGTCCAGCTAATTCTTGTATTTTTAGTAGAGATGGGGTTTCATCATATTGGACAGGCTGATCTTGAACTCCTGACCTCAGATGATCCACCTGCCTCAGCCTCCCAAAGTGGTGGGATTACAGGCGTGAGCCACCACGCCTGGCCAGTTATATCTTTTTACCTGACGAAAACTGTAAACAACTTTTGGCATTCTACGCCTTTCAAAACAATTCAACTTTTTTTTTTTTTTTTAAATTTAAATCATGGAATTCAGATGAGCCTTCAAGGCAATTAATGTGAGTTAGGTCATATTGAACCTGTGTTTAGAGATACGTAAGGACTTTGATTAGTGCCCATCTTGTGCCAGCTTGTATTTCCCGTTTAGAGTTGGCAAAGGACAACATGTTGTAGCATTGGTCTTAGATGAATTATTGGTCTTAGGTTTTATTACCTAAAACCTGGATTTATTTATTTTTAACAATTAACCGAACTGTGACATCAATATCAGTTCCCATTCTTTGGTCACAGTTTAGTCATTTGAGAAAGGGTTGAGAGGCTTTTTAGGAGAAAAATTCATGCACATGCAGAGTCTACTCTAACACAGAACCACCTCACATTGAGTTTTGAAGCTAAATGATCTTTCCACGGTAATTATAATTAAGACCAGTATATTACAAAGAATCAGTTTACCAAAAAGAACTTTAAAAACCCTGAAGAACTAGGCCACATGCCTAGTTCACACCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGCGGATCACCTGAGGTCAGGAGTTCGAGACCAGACTGACCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAATTATCTGGGCATGGTGGTGCATGCCTGTAATCCCAGCTATTTGGGAGGCTGAGGCTGGAGAATAGCTTGAATCTGGGATTCTGGGAGGTGGAGGTTGCAATAAGCCAAGATCATGCCATTGCACACCAGCCTGGGCAACAAGAGTGAAACTGTCTAAAAAAAAAAAGGCCAGCTGGGGACTGAGGAGCAATTTGGGGTTATGTTGATCTTCTTGGGCTGGCAGAGTCTCTGGGCAACAGAGTTCATGCAGCTGGATTAAGGTTGCACCCTGTAGTTTCTCTTTCCACTTGGACAGAAATGGAGGTGTTGGGCCTATAATCTGGTCCTTGCCCAAAGCCAAGTTAGTGTTATGCAGTATTTCTGTTTTGAACACATTTGTCCTTATTTTCCCTTTTCTCTTCTTGCCCACTAGTAGGGAAAAAAATAATCCGAGTTATTTGCTTGGGTGGAGCCACTCTTTGATTGCAATGCCCCAGGGTTTTCTAGGTTAACAAATTGGAGCTTTCCAGCCGGCTGAGTAGGGGTGGGCTACAGCTCTTCTACCCTGCCTTCTCATATTCCTTTCCTTCCTTCCCACTCCAGAAGAGAAAGCAGAGGCCTGGTTGCTGAGTGTGGAGGACATGCTGTTTTGGGGAGCCTAGGGACTGTTGACCACAGCTGTGTCTTTTTGTGGAGAGGAGTTTCAGCATATTCTTGGAAG endometrial cancer 29334253 Circular RNA expression in extracellular vesicles isolated from serum of patients with endometrial cancer. Xu H, Gong Z, Shen Y, Fang Y, Zhong S. Epigenomics. 2018 up RNA-seq, northern blots extracellular vesicles isolated from serum of patients with endometrial cancer hsa_circ_0131551 circRNA homo sapiens TDP2 hsa_circ_0131551 GTGATTTCATCATTATGCAAACATCATAGAGAGAATTTACACAAACCTAGATGGTACAACAGCCTCCTACACACCTAGGCTATATGGTCTAGCCTACTGCTCCTAGGCTACAAACCTGTACAGCATGCTACTATACTGGATACTGTAGGCAACTGTAACACAATGGCACTTACTTGTGTTCTAAAAATACCTAATATAGAAAAGGTATAGCAAAAATACAGTAATATAATCTTATGGGATCATCTTCATTTATGCAGTTTGTTGTCAATAGAGATGTGGTTATGTG endometrial cancer 29334253 Circular RNA expression in extracellular vesicles isolated from serum of patients with endometrial cancer. Xu H, Gong Z, Shen Y, Fang Y, Zhong S. Epigenomics. 2018 down RNA-seq, northern blots extracellular vesicles isolated from serum of patients with endometrial cancer hsa_circ_0133980 circRNA homo sapiens STK31 hsa_circ_0133980 GGCACAACCTTTTTGGGGAGCTTGATTTTTGAAAAGGAAATAAAAATGAGAATTAAAGCAACCTCTGAAGATGGAACAGTTATTGCTCAGGCTGAGTATGGCAGTGTGGATATAGGGGAAGAGGTGCTTAAGAAAGGATTTGCAGAGAAATGCAGACTTGCTTCCAGAACTGACATCTGTGAGGAAAAAAAATTGGATCCTGGTCAACTTGTTCTCAGGAACCTCAAAAGCCCCATTCCTTTGTGGGGGCATAGATCAAACCAGTCAACCTTCAGCAGGCCCAAGGGGCACTTAAGTGAGAAAATGACTCTTGACTTGAAGGATGAAAATGATGCAGGCAATCTTATAACATTTCCAAAGGAAAGTTTGGCTGTTGGTGACTTTAATTTAGGGTCTAACGTCAGCCTGGAAAAAATTAAGCAGGACCAGAAACTGATTGAAGAAAATGAAAAACTTAAAACAGAGAAGGACGCTCTTCTTGAAAGTTATAAGGCGTTAGAATTGAAAGTAGAGCAGATTGCCCAGGAGCTGCAG male infertile diseases 27958373 Identification and characterization of human testis derived circular RNAs and their existence in seminal plasma. Dong WW, Li HM, Qing XR, Huang DH, Li HG. Sci Rep. 2016 To validate these predicted circRNAs, 55 circRNAs of different abundance and lengths were randomly chosen for subsequent RT-PCR validation. Divergent primers were designed for circRNA detection. Among the 55 circRNAs, 30 of them could be specifically amplified. qRT-PCR human testis hsa_circ_0138960 circRNA homo sapiens GDA hsa_circ_0138960 TGAGTTCTTCATGCCTGGGCTGGTTGATACACACATCCATGCCTCTCAGTATTCCTTTGCTGGAAGTAGCATAGACCTGCCACTCTTGGAGTGGCTGACCAAGTACACATTTCCTGCAGAACACAGATTCCAGAACATCGACTTTGCAGAAGAAGTATATACCAGAGTTGTCAGGAGAACACTAAAGAATGGAACAACCACAGCTTGTTACTTTGCAACAATTCACACTGACTCATCTCTGCTCCTTGCCGACATTACAGATAAATTTGGACAGCGGGCATTTGTGGGCAAAGTTTGCATGGATTTGAATGACACTTTTCCAGAATACAAGGAGACCACTGAGGAATCGATCAAGGAAACTGAGAG gastric cancer 28980874 Analysis of co-expression networks for circular RNAs and mRNAs reveals that circular RNAs hsa_circ_0047905, hsa_circ_0138960 and has-circRNA7690-15 are candidate oncogenes in gastric cancer. Lai Z, Yang Y, Yan Y, Li T, Li Y, Wang Z, Shen Z, Ye Y, Jiang K, Wang S. Cell Cycle. 2017 upregulated in GC tissues compared with noncancerous tissue microarray, qRT-PCR GC tissues and noncancerous tissue, AGS Depletion of circRNA0138960 suppressed AGS cell proliferation and invasion in vitro. The AUC of circRNA0138960 was 0.647 (95% CI: 0.508-0.786). loss of function AGS GC tissues hsa_circ_0139110 circRNA homo sapiens FRMD3 hsa_circ_0139110 ATACCTTTTATACCTTCAGATTAAAAGGGACATTTTTCATGGCCGCCTGCTGTGCTCCTTTTCTGATGCTGCCTACCTGGGTGCCTGTATTGTTCAAGCTGAGCTTGGTGATTACGATCCTGATGAGCATCCTGAGAATTACATCAGTGAGTTTGAGATTTTCCCCAAGCAGTCACAGAAGCTGGAAAGAAAAATAGTGGAAATTCATAAAAATGAACTCAG type 2 diabetes mellitus 27878383 Hsa_circ_0054633 in peripheral blood can be used as a diagnostic biomarker of pre-diabetes and type 2 diabetes mellitus. Zhao Z, Li X, Jian D, Hao P, Rao L, Li M. Acta Diabetol. 2017 The levels of hsa_circ_0139110 expression among the three groups presented no significant differences. qRT-PCR, microarray peripheral blood of T2DM, pre-diabetes and control groups ecircRNA-GSDMB circRNA homo sapiens GSDMB hsa_circ_0141336 Multiple Sclerosis 28272342 The Characterization of GSDMB Splicing and Backsplicing Profiles Identifies Novel Isoforms and a Circular RNA That Are Dysregulated in Multiple Sclerosis. Cardamone G, Paraboschi EM, Rimoldi V, Duga S, Soldà G, Asselta R. Int J Mol Sci. 2017 Real-time RT-PCR performed on RNA extracted from PBMCs showed a significant upregulation of the GSDMB ecircRNA in MS cases with respect to controls. qRT-PCR MS cases, controls hsa_circ_082319 circRNA homo sapiens hsa_circ_082319 Primary Biliary Cholangitis 29183005 Microarray Expression Profile of Circular RNAs in Plasma from Primary Biliary Cholangitis Patients. Zheng J, Li Z, Wang T, Zhao Y, Wang Y. Cell Physiol Biochem. 2017 Down-regulated circular RNAs in the plasma from PBC patients compared with that from healthy individuals microarray, qRT-PCR the plasma from PBC patients and healthy individuals hsa_circ_087631 circRNA homo sapiens hsa_circ_087631 Primary Biliary Cholangitis 29183005 Microarray Expression Profile of Circular RNAs in Plasma from Primary Biliary Cholangitis Patients. Zheng J, Li Z, Wang T, Zhao Y, Wang Y. Cell Physiol Biochem. 2017 Up-regulated circular RNAs in the plasma from PBC patients compared with that from healthy individuals microarray, qRT-PCR the plasma from PBC patients and healthy individuals hsa_circ_09585 circRNA homo sapiens hsa_circ_09585 pulmonary tuberculosis 29371930 Identification and comparison of novel circular RNAs with associated co-expression and competing endogenous RNA networks in pulmonary tuberculosis. Zhang X, Zhu M, Yang R, Zhao W, Hu X, Gan J. Oncotarget. 2017 Upregulated in PTB patients compared to healthy individuals. RNA-seq, qRT-PCR PTB patients, healthy individuals hsa_circ_09993 circRNA homo sapiens hsa_circ_09993 pulmonary tuberculosis 29371930 Identification and comparison of novel circular RNAs with associated co-expression and competing endogenous RNA networks in pulmonary tuberculosis. Zhang X, Zhu M, Yang R, Zhao W, Hu X, Gan J. Oncotarget. 2017 Downregulated in PTB patients compared to healthy individuals. RNA-seq, qRT-PCR PTB patients, healthy individuals circRNA_100338 circRNA homo sapiens SNX27 hsa_circ_100338 hepatocellular carcinoma 28710406 Comprehensive circular RNA profiling reveals the regulatory role of the circRNA-100338/miR-141-3p pathway in hepatitis B-related hepatocellular carcinoma. Huang XY, Huang ZL, Xu YH, Zheng Q, Chen Z, Song W, Zhou J, Tang ZY, Huang XY. Sci Rep. 2017 upregulated in HCC microarray, qRT-PCR HCC tissues and paired pericancerous tissues, Hep3B, BEL7402, MHCC97H and HCCLM6 Expression levels of circRNA_100338 in HCC patients are highly correlated with cancer metastatic progression and, consequently, the cumulative survival rate. circRNA_100338 and miR-141-3p regulate the metastatic potential of liver cancer cells. gain of function MHCC97H HCC tissues miR-141-3p circRNA-miRNA HEK293T, HCC tissues luciferase reporter assay, expression Co-transfection with miR-141-3p mimic or co-transfection with scramble RNA in circRNA_100338-expressing HEK293T cells led to comparable expression of luciferase when the miR-141-3p binding site was mutated in circRNA_100338. The expression of circRNA_100338 was significantly upregulated by approximately 3~4-fold in HCC tissues compared with that in paired pericancerous tissues\. In sharp contrast to circRNA_100338, the expression of miR-141-3p in HCC tissues was downregulated compared with that in paired pericancerous tissues by approximately five fold and with high statistical significance (P < 0.001). Circular RNA_LARP4 circRNA homo sapiens hsa_circ_101057 gastric cancer 28893265 Circular RNA_LARP4 inhibits cell proliferation and invasion of gastric cancer by sponging miR-424-5p and regulating LATS1 expression. Zhang J, Liu H, Hou L, Wang G, Zhang R, Huang Y, Chen X, Zhu J. Mol Cancer. 2017 downregulated in GC microarray, qRT-PCR, FISH GES-1, SGC-7901, MKN-45, MKN-28, HGC-27, MGC-803, AGS, BGC-823, GC patients and adjacent normal tissues Ectopic expression of circLARP4 inhibited cell growth and colony-forming capacity of GC cells, while knockdown of circLARP4 reversed these effects. The proliferation of HGC-27 cells was impaired by transfection with circLARP4 overexpression vector, but was strengthened by knockdown of circLARP4. Cell invasive potential was weakened by circLARP4 overexpression, but was enhanced by knockdown of circLARP4. circLARP4 Acts as an independent prognostic factor for OS of GC patients. gain of function, loss of function HGC-27 and MKN-28 cells GC tissues and the pair-matched normal tissues miR-424-5p circRNA-miRNA HEK293T, HGC-27 and MKN-28 cells luciferase reporter assay, AGO3 RIP Compared with the negative control (NC), miR-424 lowered the luciferase reporter activity by approximately 75%, indicating that miR-424 might have the greater potential to bind to circLARP4. circLARP4 and miR-424 were highly expressed in the AGO2 pellet compared with those in the input control. LATS1 hsa_circ_101139 circRNA homo sapiens ATP2A2 hsa_circ_101139 hepatocellular carcinoma 28710406 Comprehensive circular RNA profiling reveals the regulatory role of the circRNA-100338/miR-141-3p pathway in hepatitis B-related hepatocellular carcinoma. Huang XY, Huang ZL, Xu YH, Zheng Q, Chen Z, Song W, Zhou J, Tang ZY, Huang XY. Sci Rep. 2017 downregulated in HCC microarray, qRT-PCR HCC tissues and paired pericancerous tissues hsa_circ_101222 circRNA homo sapiens hsa_circ_101222 pre-eclampsia 26846540 Circular RNA in blood corpuscles combined with plasma protein factor for early prediction of pre-eclampsia. Zhang YG, Yang HL, Long Y, Li WL. BJOG. 2016 The circ_101222 levels in blood corpuscles of patients with PE were significantly higher than those in corresponding healthy women (P < 0.001). microarray, qRT-PCR blood corpuscle samples from women with PE and gestational and maternal age-matched healthy control women hsa_circ_101555 circRNA homo sapiens hsa_circ_101555 cutaneous squamous cell carcinoma 27298156 Circular RNA expression in cutaneous squamous cell carcinoma. Sand M, Bechara FG, Gambichler T, Sand D, Bromba M, Hahn SA, Stockfleth E, Hessam S. J Dermatol Sci. 2016 up microarray, qRT-PCR, FISH cutaneous squamous cell carcinoma (cSCC) and non-lesional epithelial skin (NLES) tissues hsa_circ_102049 circRNA homo sapiens TADA2A hsa_circ_102049 hepatocellular carcinoma 28710406 Comprehensive circular RNA profiling reveals the regulatory role of the circRNA-100338/miR-141-3p pathway in hepatitis B-related hepatocellular carcinoma. Huang XY, Huang ZL, Xu YH, Zheng Q, Chen Z, Song W, Zhou J, Tang ZY, Huang XY. Sci Rep. 2017 downregulated in HCC microarray, qRT-PCR HCC tissues and paired pericancerous tissues hsa_circ_102533 circRNA homo sapiens UBA2 hsa_circ_102533 hepatocellular carcinoma 28710406 Comprehensive circular RNA profiling reveals the regulatory role of the circRNA-100338/miR-141-3p pathway in hepatitis B-related hepatocellular carcinoma. Huang XY, Huang ZL, Xu YH, Zheng Q, Chen Z, Song W, Zhou J, Tang ZY, Huang XY. Sci Rep. 2017 upregulated in HCC microarray, qRT-PCR HCC tissues and paired pericancerous tissues hsa_circ_102533 circRNA homo sapiens hsa_circ_102533 leukoaraiosis 28677780 Spectrum construction of differentially expressed circular RNAs in patients with leukoaraiosis and function analysis of differentially expressed genes. Mi T, Luo C, Hu Y, Qu C, Wang X, Guo S, Du Y. Mol Med Rep. 2017 Significantly higher in the LA group compared with the control group. microarray, qRT-PCR LA sufferers, controls hsa_circ_102922 circRNA homo sapiens SGPP2 hsa_circ_102922 hepatocellular carcinoma 28710406 Comprehensive circular RNA profiling reveals the regulatory role of the circRNA-100338/miR-141-3p pathway in hepatitis B-related hepatocellular carcinoma. Huang XY, Huang ZL, Xu YH, Zheng Q, Chen Z, Song W, Zhou J, Tang ZY, Huang XY. Sci Rep. 2017 upregulated in HCC microarray, qRT-PCR HCC tissues and paired pericancerous tissues hsa_circ_103736 circRNA homo sapiens hsa_circ_103736 cutaneous squamous cell carcinoma 27298156 Circular RNA expression in cutaneous squamous cell carcinoma. Sand M, Bechara FG, Gambichler T, Sand D, Bromba M, Hahn SA, Stockfleth E, Hessam S. J Dermatol Sci. 2016 up microarray, qRT-PCR, FISH cutaneous squamous cell carcinoma (cSCC) and non-lesional epithelial skin (NLES) tissues hsa_circ_103737 circRNA homo sapiens hsa_circ_103737 cutaneous squamous cell carcinoma 27298156 Circular RNA expression in cutaneous squamous cell carcinoma. Sand M, Bechara FG, Gambichler T, Sand D, Bromba M, Hahn SA, Stockfleth E, Hessam S. J Dermatol Sci. 2016 up microarray, qRT-PCR, FISH cutaneous squamous cell carcinoma (cSCC) and non-lesional epithelial skin (NLES) tissues hsa_circ_103783 circRNA homo sapiens hsa_circ_103783 leukoaraiosis 28677780 Spectrum construction of differentially expressed circular RNAs in patients with leukoaraiosis and function analysis of differentially expressed genes. Mi T, Luo C, Hu Y, Qu C, Wang X, Guo S, Du Y. Mol Med Rep. 2017 Significantly higher in the LA group compared with the control group. microarray, qRT-PCR LA sufferers, controls hsa_circ_104075 circRNA homo sapiens NUP153 hsa_circ_104075 hepatocellular carcinoma 28710406 Comprehensive circular RNA profiling reveals the regulatory role of the circRNA-100338/miR-141-3p pathway in hepatitis B-related hepatocellular carcinoma. Huang XY, Huang ZL, Xu YH, Zheng Q, Chen Z, Song W, Zhou J, Tang ZY, Huang XY. Sci Rep. 2017 upregulated in HCC microarray, qRT-PCR HCC tissues and paired pericancerous tissues hsa_circ_104838 circRNA homo sapiens hsa_circ_104838 Oral squamous cell carcinoma (OSCC) 29286141 CircDOCK1 suppresses cell apoptosis via inhibition of miR-96a-5p by targeting BIRC3 in OSCC. Wang L, Wei Y, Yan Y, Wang H, Yang J, Zheng Z, Zha J, Bo P, Tang Y, Guo X, Chen W, Zhu X, Ge L. Oncol Rep. 2018 downregulated microarray, qRT-PCR CAL 27 stimulated with 100 ng/ml recombinant human TNF-¦Á and negative control hsa_circ_13478 circRNA homo sapiens hsa_circ_13478 pulmonary tuberculosis 29371930 Identification and comparison of novel circular RNAs with associated co-expression and competing endogenous RNA networks in pulmonary tuberculosis. Zhang X, Zhu M, Yang R, Zhao W, Hu X, Gan J. Oncotarget. 2017 Downregulated in PTB patients compared to healthy individuals. RNA-seq, qRT-PCR PTB patients, healthy individuals hsa_circ_401491 circRNA homo sapiens hsa_circ_401491 hepatocellular carcinoma 29144509 Circular RNA expression is suppressed by androgen receptor (AR)-regulated adenosine deaminase that acts on RNA (ADAR1) in human hepatocellular carcinoma. Shi L, Yan P, Liang Y, Sun Y, Shen J, Zhou S, Lin H, Liang X, Cai X. Cell Death Dis. 2017 upregulated more than fivefold as revealed by circRNA microarray after AR knocking down in MHCC-102h cells microarray, qRT-PCR MHCC-97h, LM3 and LO8 cells hsa_circ_401977 circRNA homo sapiens hsa_circ_401977 lung adenocarcinoma 29241190 CircRNA Expression Profile in Early-Stage Lung Adenocarcinoma Patients. Zhao J, Li L, Wang Q, Han H, Zhan Q, Xu M. Cell Physiol Biochem. 2017 down-regulated in lung cancer microarray, qRT-PCR tumors and paired adjacent normal tissue from non-smoking patients with lung adenocarcinoma, A549, H1299, BEAS-2B, B2B miR-26a-3p, miR-519d-5p, miR-629-5p circRNA-miRNA predicted hsa_circ_402458 circRNA homo sapiens hsa_circ_402458 Primary Biliary Cholangitis 29183005 Microarray Expression Profile of Circular RNAs in Plasma from Primary Biliary Cholangitis Patients. Zheng J, Li Z, Wang T, Zhao Y, Wang Y. Cell Physiol Biochem. 2017 Up-regulated circular RNAs in the plasma from PBC patients compared with that from healthy individuals. hsa_circ_402458 was significantly higher in PBC patients not receiving UDCA treatment than in PBC patients receiving UDCA treatment (P=0.0338). microarray, qRT-PCR the plasma from PBC patients and healthy individuals hsamiR-522-3p and hsa-miR-943 circRNA-miRNA predicted For hsa_circ_402458, two putative miRNA targets, hsamiR-522-3p and hsa-miR-943, were predicted. hsa_circ_404833 circRNA homo sapiens hsa_circ_404833 lung adenocarcinoma 29241190 CircRNA Expression Profile in Early-Stage Lung Adenocarcinoma Patients. Zhao J, Li L, Wang Q, Han H, Zhan Q, Xu M. Cell Physiol Biochem. 2017 up-regulated in lung cancer microarray, qRT-PCR tumors and paired adjacent normal tissue from non-smoking patients with lung adenocarcinoma, A549, H1299, BEAS-2B, B2B miR-149-5p circRNA-miRNA predicted hsa_circ_406329 circRNA homo sapiens hsa_circ_406329 Primary Biliary Cholangitis 29183005 Microarray Expression Profile of Circular RNAs in Plasma from Primary Biliary Cholangitis Patients. Zheng J, Li Z, Wang T, Zhao Y, Wang Y. Cell Physiol Biochem. 2017 Up-regulated circular RNAs in the plasma from PBC patients compared with that from healthy individuals microarray, qRT-PCR the plasma from PBC patients and healthy individuals hsa_circ_406483 circRNA homo sapiens hsa_circ_406483 lung adenocarcinoma 29241190 CircRNA Expression Profile in Early-Stage Lung Adenocarcinoma Patients. Zhao J, Li L, Wang Q, Han H, Zhan Q, Xu M. Cell Physiol Biochem. 2017 up-regulated in lung cancer microarray, qRT-PCR tumors and paired adjacent normal tissue from non-smoking patients with lung adenocarcinoma, A549, H1299, BEAS-2B, B2B miR-493-3p circRNA-miRNA predicted hsa_circ_406697 circRNA homo sapiens hsa_circ_406697 breast cancer 28484086 Identification of circular RNAs as a promising new class of diagnostic biomarkers for human breast cancer. Lü L, Sun J, Shi P, Kong W, Xu K, He B, Zhang S, Wang J. Oncotarget. 2017 downregulated microarray, qRT-PCR Breast cancer lesions and adjacent normal-appearing tissues area under the curve (AUC) is 0.64 Breast cancer lesions and adjacent normal-appearing tissues hsa_circ_406960 circRNA homo sapiens hsa_circ_406960 hepatocellular carcinoma 29144509 Circular RNA expression is suppressed by androgen receptor (AR)-regulated adenosine deaminase that acts on RNA (ADAR1) in human hepatocellular carcinoma. Shi L, Yan P, Liang Y, Sun Y, Shen J, Zhou S, Lin H, Liang X, Cai X. Cell Death Dis. 2017 upregulated more than fivefold as revealed by circRNA microarray after AR knocking down in MHCC-109h cells microarray, qRT-PCR MHCC-97h, LM3 and LO15 cells hsa_circ_407176 circRNA homo sapiens hsa_circ_407176 Primary Biliary Cholangitis 29183005 Microarray Expression Profile of Circular RNAs in Plasma from Primary Biliary Cholangitis Patients. Zheng J, Li Z, Wang T, Zhao Y, Wang Y. Cell Physiol Biochem. 2017 Down-regulated circular RNAs in the plasma from PBC patients compared with that from healthy individuals microarray, qRT-PCR the plasma from PBC patients and healthy individuals CircHIPK3 circRNA homo sapiens HIPK3 bladder cancer 27050392 Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs. Zheng Q, Bao C, Guo W, Li S, Chen J, Chen B, Luo Y, Lyu D, Li Y, Shi G, Liang L, Gu J, He X, Huang S. Nat Commun. 2016 circHIPK3 is commonly expressed in various tissues and particularly enriched in the brain. RNA-seq, qRT-PCR, northern blots, FISH Human normal (brain, heart, liver, lung, colon and stomach) and cancerous (primary hepatocellular carcinoma, CRC, GC, KCA, BLCA, BC and PRAD) samples. HeLa, Huh-7 and HCT-116. Silencing of circHIPK3 inhibits human cell proliferation. loss of function, gain of function HeLa, Huh-7 and HCT-116 miR-124, miR-152, miR-193a, miR-29a, miR-29b, miR-338, miR-379, miR-584 and miR-654 circRNA-miRNA HEK-293T AGO2 RIP, luciferase reporter assay Compared with the control RNA, 9 miRNAs (miR-124, miR-152, miR-193a, miR-29a, miR-29b, miR-338, miR-379, miR-584 and miR-654) out of the 424 miRNAs were able to reduce the luciferase reporter activities by at least 30%. IL6R and DLX2 circRNA-MYLK circRNA homo sapiens MYLK bladder cancer 28687357 Circular RNA MYLK as a competing endogenous RNA promotes bladder cancer progression through modulating VEGFA/VEGFR2 signaling pathway. Zhong Z, Huang M, Lv M, He Y, Duan C, Zhang L, Chen J. Cancer Lett. 2017 circRNA-MYLK and VEGFA were significantly up-regulated and co-expressed in BC. microarray, qRT-PCR bladder carcinomas and matched para-carcinomas, EJ, T24, 5673 and BIU-87 circRNA-MYLK levels were related to the progression of stage and grade of BC. Ectopically expressing circRNA-MYLK accelerated cell proliferation, migration, tube formation of HUVEC and rearranged cytoskeleton. Moreover, up-regulating circRNA-MYLK promoted epithelial-mesenchymal transition (EMT). Whereas circRNA-MYLK knockdown decreased cell proliferation, motility, and induced apoptosis. Finally, up-regulating circRNA-MYLK promoted the growth, angiogenesis and metastasis of BC xenografts. gain of function, loss of function EJ and T24 cells 4-week-old male BALB/c mice bladder carcinomas and matched para-carcinomas miR-29a circRNA-miRNA 293T, EJ AGO2 RIP, luciferase reporter assay, RNA FISH circRNA-MYLK pulled down with Anti-Ago2 antibodies was significantly enriched in cells transfected with miR-29a mimics compared to controls. circRNA-MYLK and miR-29a are colocalized in BC tissues and cells using FISH. Upregulation of miR-29a could remarkably reduce the luciferase activities of WT reporter but not the Mutant one, suggesting that miR-29a could interact with circRNA-MYLK via complementary seed region. VEGFA circRNA_100290 circRNA homo sapiens SLC30A7 oral squamous cell carcinoma (OSCC) 28368401 circRNA_100290 plays a role in oral cancer by functioning as a sponge of the miR-29 family. Chen L, Zhang S, Wu J, Cui J, Zhong L, Zeng L, Ge S. Oncogene. 2017 The expression of circRNA_100290 in OSCC was upregulated by nearly sevenfold. microarray, qRT-PCR Tissue samples of OSCC and paired NCMT, SCC9, CAL27, HN4 and Human oral keratinocytes Silencing of circRNA_100290 induced G1/S arrest in SCC9 cell lines. Cell proliferation was significantly reduced in the circRNA_100290 knockdown group. Silencing of circRNA_100290 markedly decreased the growth of the tumours in vivo. loss of function SCC9, CAL27, HN4 BALB/C-nu/nu, female and 5-week-old miR-29b circRNA-miRNA Tissue samples of OSCC and paired NCMT, HEK293T circRNA microarray data and mRNA microarray data, luciferase reporter assay miR-29b-3p, miR-29c-3p and miR-29a-3p were the top three predicted miRNA targets of circRNA_100290.. Co-transfection of luciferase reporters containing a 3¡äUTR sequence and miR-29b mimics into 293T cells reduced over 60% of the luciferase intensity. CDK6 circTCF25 circRNA homo sapiens TCF25 bladder cancer 27484176 Screening differential circular RNA expression profiles reveals the regulatory role of circTCF25-miR-103a-3p/miR-107-CDK6 pathway in bladder carcinoma. Zhong Z, Lv M, Chen J. Sci Rep. 2016 up in BC microarray, qRT-PCR bladder carcinoma tissue and matched para-carcinoma tissue, T24 and EJ cells The circTCF25 promotes proliferation and migration of bladder cancer cells via circTCF25-miR-103a-3p/miR-107-CDK6 pathway. gain of function T24, EJ miR-103a-3p/miR-107 circRNA-miRNA T24, EJ expression Then, we observed that the expressions of miR-103a-3p and miR-107 were down-regulated significantly in over-expression circTCF25 group compared with mock control in T24 and EJ cells. Meanwhile, the expression levels of miR-103a-3p and miR-107 in bladder carcinoma tissues were lower than those in para-carcinoma tissues by qPCR. CircDOCK1 circRNA homo sapiens DOCK1 hsa_circ_100721 Oral squamous cell carcinoma (OSCC) 29286141 CircDOCK1 suppresses cell apoptosis via inhibition of miR-96a-5p by targeting BIRC3 in OSCC. Wang L, Wei Y, Yan Y, Wang H, Yang J, Zheng Z, Zha J, Bo P, Tang Y, Guo X, Chen W, Zhu X, Ge L. Oncol Rep. 2018 The expression level of circDOCK1 (circ_100721) was significantly downregulated in the apoptosis model compared to the negative control. circDOCK1 was distinctly upregulated in OSCC cell lines and OSCC tissue. microarray, qRT-PCR CAL 27 stimulated with 100 ng/ml recombinant human TNF-¦Á and negative control, oral carcinoma tissues and adjacent normal tissues, HOK, CAL 27, SCC-9 and SCC 25 circDOCK1 regulated the apoptosis of OSCC cell lines. loss of function CAL 27 and SCC-9 cells miR 196a 5p circRNA-miRNA CAL-27, SCC-9, Oral carcinoma tissues and adjacent normal tissues expression Following transfection for 48 h, the expression levels of miR 196a 5p were upregulated distinctly in the low-expression circDOCK1 group compared with the negative control in CAL 27 and SCC-9 cells, the expression levels of miR 196a 5p in the OSCC tissue were lower than those in the para carcinoma tissue as determined by qRT PCR. BIRC3 Cdr1as circRNA homo sapiens CDR2 hepatocellular carcinoma 27391479 The Circular RNA Cdr1as Act as an Oncogene in Hepatocellular Carcinoma through Targeting miR-7 Expression. Yu L, Gong X, Sun L, Zhou Q, Lu B, Zhu L. PLoS One. 2016 upregulated in HCC qRT-PCR HCC tissues and adjacent non-tumor tissues, Hep3B, HepG2, SMMC-7721, Bel7402 and HL-7702 Knockdown of Cdr1as suppressed the HCC cell proliferation and invasion. loss of function HepG2, SMMC-7721 miR-7 circRNA-miRNA HCC tissues and adjacent non-tumor tissues, HepG2, SMMC-7721 expression Cdr1asexpression was upregulated in HCC tissues and was inversely associated with the expression of miR-7. Knockdown of Cdr1as promoted theexpression of miR-7 as well as its target gene CCNE1 and PIK3CD. CCNE1 and PIK3CD circRNA_000839 circRNA homo sapiens hepatocellular carcinoma 28695771 MicroRNA-200b suppresses the invasion and migration of hepatocellular carcinoma by downregulating RhoA and circRNA_000839. Wang BG, Li JS, Liu YF, Xu Q. Tumour Biol. 2017 The expressions of circ_000839 in HCC tissue were significantly higher than in normal liver tissue. qRT-PCR hepatocellular cancer and adjacent normal liver tissues, Huh7 and HepG2 miR-200b circRNA-miRNA hepatocellular cancer and adjacent normal liver tissues expression miR-200b levels were inversely correlated with the expression of circ_000839 RhoA Circular RNA CDR1as circRNA homo sapiens CDR1 Hepatocellular Carcinoma 28892615 Quantitative Proteomics Reveals the Regulatory Networks of Circular RNA CDR1as in Hepatocellular Carcinoma Cells. Yang X, Xiong Q, Wu Y, Li S, Ge F. J Proteome Res. 2017 CDR1as was downregulated in HCC microarray, qRT-PCR HepG2, Huh7, THLE-3, MCF-7, HeLa, HEK293T, HCC tissues and adjacent liver tissues The CCK-8 assay showed that cell growth was significantly increased after CDR1as overexpression. A lower cell migration capacity of HepG2 cells was observed after CDR1as overexpression, whereas the cell invasion ability was unaffected. Meanwhile, overexpression of CDR1as in HCC cells resulted in enhanced cell adhesion to fibronectin and promoted G1/S phase transition. gain of function HepG2 miR-7 circRNA-miRNA HepG2 expression miR-7 was significantly downregulated after CDR1as overexpression EGFR CircRNA BCRC4 circRNA homo sapiens RANBP9 bladder cancer 29270748 Overexpression of CircRNA BCRC4 regulates cell apoptosis and MicroRNA-101/EZH2 signaling in bladder cancer. Li B, Xie F, Zheng FX, Jiang GS, Zeng FQ, Xiao XY. J Huazhong Univ Sci Technolog Med Sci. 2017 decreased in BC qRT-PCR UMUC3, SV-HUC-1, T24T, bladder cancer tissues and surrounding normal adjacent bladder tissues Inhibitory Effects of BCRC4 Over-expression on Viability and Apoptosis of BC Cells In Vitro. gain of function UMUC3, T24T miR-101 circRNA-miRNA UMUC3, T24T expression The miR-101 level was detected after overexpression of BCRC4. The miR-101-3p expression was significantly increased in cells transfected with BCRC4 as compared with controls. EZH2 Up-regulation of BCRC4 Expression by GA (a natural product with known anti-cancer properties can promote apoptosis of BC cells by inhibiting EZH2 expression) Treatment. Circ100284 circRNA homo sapiens carcinogenesis of human keratinocytes 28062277 Circ100284, via miR-217 regulation of EZH2, is involved in the arsenite-accelerated cell cycle of human keratinocytes in carcinogenesis. Xue J, Liu Y, Luo F, Lu X, Xu H, Liu X, Lu L, Yang Q, Chen C, Fan W, Liu Q. Biochim Biophys Acta. 2017 increased by arsenite in HaCaT cells qRT-PCR HaCaT, arsenite-treated HaCaT (As-HaCaT) cells and in arsenite-transformed (T-HaCaT) cells Knockdown of circ100284 with siRNA inhibited the capacity of T-HaCaT cells for colony formation, invasion, and migration, effects that were reversed by co-transfection with a miR-217 inhibitor or by epigenetic expression of EZH2. loss of function HaCaT, T-HaCaT miR-217 circRNA-miRNA HaCaT, T-HaCaT expression and function Flow cytometry was performed and showed that inhibited G1/S transition was observed in As-HaCaT cells transfected with circ100284 siRNA, but co-transfected with miR-217 inhibitor restored the inhibition EZH2 circ-Foxo3 circRNA homo sapiens Foxo3 cancer 27886165 Induction of tumor apoptosis through a circular RNA enhancing Foxo3 activity. Du WW, Fang L, Yang W, Wu N, Awan FM, Yang Z, Yang BB. Cell Death Differ. 2017 In patient tumor samples and in a panel of cancer cells, circ-Foxo3 was minimally expressed. During cancer cell apoptosis, the expression of circ-Foxo3 was found to be significantly increased. qRT-PCR specimens of patients with breast carcinoma and benign tissues, 293T, Beas2B, HaCaT, NIH3T3, MEF, MCF-10A, MB-468, MB-231, 67NR, 66C14, 4T07, 4T1, B16 Silencing endogenous circ-Foxo3 enhanced cell viability, whereas ectopic expression of circ-Foxo3 triggered stress-induced apoptosis and inhibited the growth of tumor xenografts. loss of function, gain of function 66C14, 4T1, MDA-MB-468, and MDA-MB-231 regular Balb/c mice, nude mice, four-week-old C57 mice MDM2 and p53 circRNA-protein MB-231 FISH, NPDock, pull-down In situ hybridization displayed colocalization of circ-Foxo3 with Mdm2, p53, Foxo3, and Puma. The molecular simulation result supported that circ-Foxo3 could perfectly dock MDM2 and predicted a minimal binding region of circ-Foxo3 for the MDM2 as ¡®agucgauucaugcggguccagaaugagggaacuggcaaga¡¯. The molecular simulation result supported that circ-Foxo3 could perfectly dock p53 and predicts a minimal binding region of circ-Foxo3 for p53 as ¡®gggugccaggcugaaggaucacug¡¯. We found that the biotinylated probe pulled down significantly lower levels of circ-Foxo3 when the cells were transfected with the siRNA. circRNA_100782 circRNA homo sapiens pancreatic carcinoma 29255366 CircRNA_100782 regulates pancreatic carcinoma proliferation through the IL6-STAT3 pathway. Chen G, Shi Y, Zhang Y, Sun J. Onco Targets Ther. 2017 circRNA_100782 was markedly upregulated in PDAC. qRT-PCR BxPC3 and HPDE Knockdown of circRNA_100782 inhibited cell proliferation by downregulating the microRNA-124 (miR-124) target genes interleukin-6 receptor (IL6R) and signal transducer and activator of transcription 3 (STAT3). CircRNA _100782 knockdown repressed BxPC3 xenograft growth in vivo. loss of function BxPC3 6-week-old male BALB/c nude mice miR-124 circRNA-miRNA HEK293T luciferase reporter assay luciferase assay revealed that miR-124 was a direct target of circRNA_100782. IL6R and STAT3 circRNA_001569 circRNA homo sapiens colorectal cancer 27058418 Emerging roles of circRNA_001569 targeting miR-145 in the proliferation and invasion of colorectal cancer. Xie H, Ren X, Xin S, Lan X, Lu G, Lin Y, Yang S, Zeng Z, Liao W, Ding YQ, Liang L. Oncotarget. 2016 up-regulated in CRC qRT-PCR CRC tissue samples and matched non-tumor normal tissue samples, HCT116, SW480, LOVO, SW620 hsa_circ_001569 acted as a positive regulator in cell proliferation and invasion of colorectal cancer (CRC). Moreover, hsa_circ_001569 was identified as a sponge of miR-145 and up-regulated miR-145 functional targets E2F5, BAG4 and FMNL2. loss of function, gain of function HCT116, SW480, LOVO, SW620 miR-145 circRNA-miRNA SW480, LOVO luciferase reporter assay reduction of luciferase activity was observed upon the combination of circ_001569 and miR-145 E2F5, BAG4 and FMNL2 cir-ITCH circRNA homo sapiens ITCH Esophageal squamous cell carcinoma 25749389 Circular RNA ITCH has inhibitory effect on ESCC by suppressing the Wnt/β-catenin pathway. Li F, Zhang L, Li W, Deng J, Zheng J, An M, Lu J, Zhou Y. Oncotarget. 2015 low in ESCC RT-PCR, qRT-PCR ESCC and corresponding paracancerous tissue samples, Eca-109, TE-1 As sponge of miR-7, miR-17, and miR-214, cir-ITCH might increase the level of ITCH. ITCH hyper expression promotes ubiquitination and degradation of phosphorylated Dvl2, thereby inhibiting the Wnt/¦Â-catenin pathway. gain of function Eca-109, TE-1 4¨C5 weeks old female BALB/c nude mice miR-7, miR-17, and miR-214 circRNA-miRNA Eca-109, TE-1 luciferase reporter assay The results of the empty vector construct and miR-17 showed that luciferase activity was significantly reduced in a concentration-dependent manner in Eca-109 cells, and this trend was also present with mimics of miR-7, miR-214, miR-216b, and miR-128 in the control cells. However, in cells with cir-ITCH hyperexpression, the results showed that there were no significant differences in luciferase activity when the psiCHECK-2-ITCH-binding-site vector and miRNAs were co-transfected into Eca-109 cells except the miR-216b and miR-128. ITCH circ_0067934 circRNA homo sapiens hepatocellular carcinoma 29458020 CircRNA circ_0067934 promotes tumor growth and metastasis in hepatocellular carcinoma through regulation of miR-1324/FZD5/Wnt/β-catenin axis. Zhu Q, Lu G, Luo Z, Gui F, Wu J, Zhang D, Ni Y. Biochem Biophys Res Commun. 2018 The expression of circ_0067934 was significantly upregulated in HCC tissues and cell lines compared to adjacent normal tissues. qRT-PCR HCC and adjacent normal tissues, BEL7402, Hep3B, HuH7, MHCC97-L, HL-7702 circ_0067934 knockdown suppressed HCC cell proliferation and metastasis in vitro and in vivo. loss of function Hep3B and HuH7 cells 6-week-old BALB/c nude mice miR-1324 circRNA-miRNA Hep3B and HuH7 cells luciferase reporter assay miR-1324 mimics inhibited the luciferase activity of Hep3B and HuH7 cells transduced with wide type circ_0067934. FZD5 CircHIPK3 circRNA homo sapiens HIPK3 hepatocellular carcinoma 29415990 circHIPK3 regulates cell proliferation and migration by sponging miR-124 and regulating AQP3 expression in hepatocellular carcinoma. Chen G, Shi Y, Liu M, Sun J. Cell Death Dis. 2018 circHIPK3 was upregulated in 41 out of 50 (82%) HCC tissues compared with that in adjacent tissues. qRT-PCR HCC tissues circHIPK3 regulated the proliferation and migration of HCC cells via the miR-124-AQP3 axis. Knockdown of circHIPK3 suppressed tumor growth in vivo. loss of function Huh7 and MHCC-LM3 cells Five-week-old nude mice miR-124 circRNA-miRNA HEK-293T luciferase reporter assay Cotransfection of pmirGLO-circHIPK3-WT and miR-124 into HEK293T cells resulted in a reduction in luciferase activity compared with that from the cotransfection of pmirGLO-circHIPK3-MUT and miR-124. AQP3 circ_0015756 circRNA homo sapiens hepatoblastoma 29414822 Expression Profiling Identifies Circular RNA Signature in Hepatoblastoma. Liu BH, Zhang BB, Liu XQ, Zheng S, Dong KR, Dong R. Cell Physiol Biochem. 2018 up microarray, qRT-PCR hepatoblastoma and adjacent normal liver samples, QSG-7701, L02, HepG2, HuH-6, and SMMC-7221 circ_0015756 silencing decreases cell viability, proliferation, and invasion in vitro. loss of function HuH-6, SMMC-7721, HepG2 miR-1250-3p circRNA-miRNA HuH-6 luciferase reporter assay The activity of RLuc-circ_0015756-WT was significantly reduced by miR-1250-3p mimic transfeciton, but not by other miRNA mimics transfeciton. circRNA_0046367 circRNA homo sapiens Hepatic Steatosis 29018509 circRNA_0046367 Prevents Hepatoxicity of Lipid Peroxidation: An Inhibitory Role against Hepatic Steatosis. Guo XY, Chen JN, Sun F, Wang YQ, Pan Q, Fan JG. Oxid Med Cell Longev. 2017 Cells with high-fat-induced steatosis (steatosis group) were characterized by the expression loss of circRNA_0046367 in comparison to those in the normal group. qRT-PCR HepG2 We uncover circRNA_0046367 to be endogenous modulator of miR-34a that underlies hepatic steatosis. In contrast to its expression loss during the hepatocellular steatosis in vivo and in vitro, circRNA_0046367 normalization abolished miR-34a¡¯s inhibitory effect on peroxisome proliferator-activated receptor ¦Á (PPAR¦Á) via blocking the miRNA/mRNA interaction with miRNA response elements (MREs). gain of function HepG2 cells Liver tissues of patients with hepatic steatosis patients with biopsy-proven hepatic steatosis and nonsteatosis controls miR-34a circRNA-miRNA HepG2 cells luciferase reporter assay These demonstrations provided substantial evidence for a direct, high-affinitive targeting of miR-34a by circRNA_0046367. PPAR¦Á circRNA_0046366 circRNA homo sapiens hepatocellular steatosis 29391755 circRNA_0046366 inhibits hepatocellular steatosis by normalization of PPAR signaling. Guo XY, Sun F, Chen JN, Wang YQ, Pan Q, Fan JG. World J Gastroenterol. 2018 Compared to the normal group, the steatosis group exhibited significant loss of circRNA_0046366 expression. qRT-PCR HepG2 cells with (steatosis group) or without (normal group) FFA-induced steatosis CircRNA_0046366 antagonizes the activity of miR-34a via MRE-based complementation. In contrast to its lowered level during FFA-induced hepatocellular steatosis, circRNA_0046366 up-regulation abolished the miR-34a-dependent inhibition of PPAR¦Á that played a critical role in metabolic signaling pathways. The circRNA_0046366-related rebalancing of lipid homeostasis led to dramatic reduction of TG content, and resulted in the ameliorated phenotype of hepatocellular steatosis. gain of function HepG2 cells miR-34a circRNA-miRNA HepG2 cells luciferase reporter assay circRNA_0046366 is an antagonist of miR-34a via targeted, complementary binding. PPAR¦Á CircRNA_100269 circRNA homo sapiens gastric cancer 28657541 CircRNA_100269 is downregulated in gastric cancer and suppresses tumor cell growth by targeting miR-630. Zhang Y, Liu H, Li W, Yu J, Li J, Shen Z, Ye G, Qi X, Li G. Aging (Albany NY). 2017 CircRNA_100269 is downregulated in gastric cancer qRT-PCR human GC specimens and their adjacent non-cancerous tissue samples CircRNA_100269 suppressed tumor growth in GC cell lines. gain of function AGS, MKN28 miR-630 circRNA-miRNA AGS and SGC7901 cells luciferase reporter assay Normalized fluorescence intensity of the reporter was significantly lower in cancer cells cotransfected with the circRNA_100269 segment and miR-630 mimics compared to controls. circ-SHKBP1 circRNA homo sapiens SHKBP1 glioma 29499945 circ-SHKBP1 Regulates the Angiogenesis of U87 Glioma-Exposed Endothelial Cells through miR-544a/FOXP1 and miR-379/FOXP2 Pathways. He Q, Zhao L, Liu Y, Liu X, Zheng J, Yu H, Cai H, Ma J, Liu L, Wang P, Li Z, Xue Y. Mol Ther Nucleic Acids. 2018 Upregulated in Glioma qRT-PCR Human glioma tissue specimens, normal brain tissues, U87, hCMEC/D3 Knockdown of circ-SHKBP1 Inhibited the Angiogenesis of GECs and the Expression of AGGF1 loss of function U87 Four-week-old BALB/C athymic nude mice miR-544a, miR-379 circRNA-miRNA HEK293T luciferase reporter assay the relative luciferase activity was significantly reduced in the SHKBP1 WT + miR-544a (+) group and the SHKBP1 WT + miR-379 (+) group FOXP1,FOXP2 hsa_circRNA_101238 circRNA homo sapiens thoracic aortic dissection 29137225 Circular RNA expression profile and potential function of hsa_circRNA_101238 in human thoracic aortic dissection. Zou M, Huang C, Li X, He X, Chen Y, Liao W, Liao Y, Sun J, Liu Z, Zhong L, Bin J. Oncotarget. 2017 Upregulated in human thoracic aortic dissection compared to age-matched normal donors. microarray, qRT-PCR human thoracic aortic dissection and age-matched normal donors hsa-miR-320a circRNA-miRNA human thoracic aortic dissection luciferase reporter assay The luciferase signal of hsa-miR-320a was suppressed by the wild-type hsa_circRNA_101238, whereas the luciferase signal of hsa-miR-320a was not affected by the mutant hsa_circRNA_101238 MMP9 cir-ITCH circRNA homo sapiens ITCH lung cancer 27642589 Circular RNA-ITCH Suppresses Lung Cancer Proliferation via Inhibiting the Wnt/β-Catenin Pathway. Wan L, Zhang L, Fan K, Cheng ZX, Sun QC, Wang JJ. Biomed Res Int. 2016 significantly decreased in lung cancer RT-PCR, qRT-PCR lung cancer biopsy specimens and paired adjacent normal tissues, A549 and NCI-H460 Ectopic expression of cir-ITCH markedly elevated its parental cancer-suppressive gene, ITCH, expression and inhibited proliferation of lung cancer cells. Molecular analysis further revealed that cir-ITCH acted as sponge of oncogenic miR-7 and miR-214 to enhance ITCH expression and thus suppressed the activation of Wnt/¦Â-cateninsignaling. gain of function A549 and NCI-H460 miR-7 and miR-214 circRNA-miRNA A549 and NCI-H460 luciferase reporter assay In both A549 cells andNCI-H460 cells transfected with empty vector (control of cir-ITCH plasmid), luciferase activity was significantly decreased in a concentration-dependent manner with the presence of miR-7/miR-214 mimic. However, there were no significant ifferences in luciferase activity of miR-7/miR-214 mimic in ells with cir-ITCH hyperexpression. ITCH cir-GLI2 circRNA homo sapiens GLI2 osteosarcoma 28695772 Circular RNA GLI2 promotes osteosarcoma cell proliferation, migration, and invasion by targeting miR-125b-5p. Li JF, Song YZ. Tumour Biol. 2017 Cir-GLI2 was upregulated in OS microarray, qRT-PCR OS tissues and adjacent non-tumor tissues, hFOB, MG63, Saos-2, HOS, and U2-OS Cir-GLI2 silencing suppressed the proliferation, migration, and invasion of OS cells loss of function MG63, Saos-2 miR-125b-5p circRNA-miRNA MG63, Saos-2 luciferase reporter assay In MG63 and Saos-2 cells, dual-luciferase reporter assay showed that the co-transfection of pGL3-cir-GLI2 wild type and miR-125b-5p mimics distinctly decreases the luciferase activity compared to NC group. circ-NT5C2 circRNA homo sapiens NT5C2 osteosarcoma 29383123 Circular RNA circ-NT5C2 acts as an oncogene in osteosarcoma proliferation and metastasis through targeting miR-448. Liu X, Zhong Y, Li J, Shan A. Oncotarget. 2017 Circ-NT5C2 was up-regulated in osteosarcoma microarray, qRT-PCR osteosarcoma tissue and adjacent normal tissue, hFOB, MG-63, U2OS, SOSP-9607 and SAOS-2 circ-NT5C2 had an AUC (area under the curve) value of 0.753. Circ-NT5C2 silencing suppressed osteosarcoma cells proliferation in vitro. Circ-NT5C2 silencing suppressed osteosarcoma cells progression in vivo and in vitro. loss of function MG-63, U2OS male BALB/c nude mice (5-6 weeks) osteosarcoma tissue and adjacent normal tissue miR-448 circRNA-miRNA HEK-293T luciferase reporter assay Luciferase reporter assay indicated that luciferase vitality was decreased when co-transfected with miR-448 mimics and circ-NT5C2 wild type, while miR-150 and miR-93 didn¡¯t have the difference. circPVT1 circRNA homo sapiens PVT1 gastric cancer 27986464 Circular RNA profile identifies circPVT1 as a proliferative factor and prognostic marker in gastric cancer. Chen J, Li Y, Zheng Q, Bao C, He J, Chen B, Lyu D, Zheng B, Xu Y, Long Z, Zhou Y, Zhu H, Wang Y, He X, Shi Y, Huang S. Cancer Lett. 2017 upregulated in GC RNA-seq, qRT-PCR paired cancer specimens and adjacent normal tissues, MGC-803 and AGS circPVT1 may promote cell proliferation by acting as a sponge for members of the miR-125 family. The level of circPVT1 was observed as an independent prognostic marker for overall survival and disease-free survival of patients with GC. loss of function MGC-803 and AGS paired cancer specimens and adjacent normal tissues, miR-125a, miR-125b and let-7b circRNA-miRNA HEK-293T luciferase reporter assay Compared with the control RNA, miR-125a, miR-125b and let-7b reduced the luciferase reporter activity by at least 25%. E2F2 circMAN2B2 circRNA homo sapiens MAN2B2 lung cancer 29550475 Circular RNA circMAN2B2 facilitates lung cancer cell proliferation and invasion via miR-1275/FOXK1 axis. Ma X, Yang X, Bao W, Li S, Liang S, Sun Y, Zhao Y, Wang J, Zhao C. Biochem Biophys Res Commun. 2018 a highly expressed novel circRNA named circMAN2B2 in lung cancer tissues microarray, qRT-PCR Tissue samples of lung cancer and paired normal tissues. BESA-2B, A549, H226, H1299 and H446 circMAN2B2 knockdown significantly inhibited cell proliferation and invasion in both H1299 and A549 lung cancer cells. loss of function H1299, A549 miR-1275 circRNA-miRNA H1299 and A549 luciferase reporter assay Luciferase activity was repressed in H1299 and A549 cells co-transfected with wild-type (WT) circ- MAN2B2 and miR-1275 mimics FOXK1 circ-ZFR circRNA homo sapiens ZFR gastric cancer 29361817 Circular RNA-ZFR Inhibited Cell Proliferation and Promoted Apoptosis in Gastric Cancer by Sponging miR-130a/miR-107 and Modulating PTEN. Liu T, Liu S, Xu Y, Shu R, Wang F, Chen C, Zeng Y, Luo H. Cancer Res Treat. 2018 Circ-ZFR was significantly downregulated in GC tissues and cells microarray, qRT-PCR GC tissues and adjacent tissue samples, GES-1, AGS, AZ521, and HGC-27 Overexpression of circ-ZFR retarded cell propagation and cell cycle and promoted apoptosis in GC. Circ-ZFR curbed GC tumor growth and affected p53 protein expression in vivo. gain of function AGS male BALB/c Nude mice (8-week-old) miR-107, miR-130a circRNA-miRNA AGS luciferase reporter assay, AGO2 RIP Overexpression of miR-107 and miR-130a both significantly repressed the luciferase activity of the luciferase reporter containing circZFR 3¡¯ UTR-WT but not the reporter containing circZFR 3¡¯-UTR-Mut. RIP assay verified that there existed some interactions between circZFR and miR-107/miR-130a both (p<0.05). PTEN circRNA-000284 circRNA homo sapiens cervical cancer 29511454 Extensive profiling of circular RNAs and the potential regulatory role of circRNA-000284 in cell proliferation and invasion of cervical cancer via sponging miR-506. Ma HB, Yao YN, Yu JJ, Chen XX, Li HF. Am J Transl Res. 2018 CircRNA-000284 is upregulated in cervical cancer cells microarray, qRT-PCR, FISH HeLa, CaSki, SiHa, C-33A, SW756, human normal cervical epithelial cells CircRNA-000284 suppresses cell proliferation and invasion via miR-506/Snail-2 pathway loss of function HeLa, SiHa miR-506 circRNA-miRNA HeLa luciferase reporter assay, AGO4 RIP CircRNA-000284 directly binds to miR-506 and suppresses miR-506 activity Snail-2 circRNA-000911 circRNA homo sapiens breast cancer 29431182 Comprehensive circular RNA profiling reveals the regulatory role of the circRNA-000911/miR-449a pathway in breast carcinogenesis. Wang H, Xiao Y, Wu L, Ma D. Int J Oncol. 2018 down microarray, qRT-PCR cancer tissues and paired adjacent non-cancerous tissues, MCF 10A, MCF-7, MDA-MB-231, MDA-MB-468, MDA-MB-453, SKBR-3 and T47D Circular RNA (circRNA)-000911 plays an anti-oncogenic role in breast cancer cells. loss of function, gain of function MCF-7, MDA-MB-231 miR-449a circRNA-miRNA MCF-7, MDA-MB-231 luciferase reporter assay, circRIP miR-449a significantly inhibited the luciferase activity of the wild-type reporter of cirRNA-000911. We found a specific enrichment of cirRNA-000911 and miR 449a as compared to the controls. Notch1 cir-ZNF609 circRNA homo sapiens ZNF609 Hirschsprung¡¯s disease 27903978 Circular RNA ZNF609 functions as a competitive endogenous RNA to regulate AKT3 expression by sponging miR-150-5p in Hirschsprungs disease. Peng L, Chen G, Zhu Z, Shen Z, Du C, Zang R, Su Y, Xie H, Li H, Xu X, Xia Y, Tang W. Oncotarget. 2017 cir-ZNF609 was down-regulated in HSCR compared with normal bowel tissues. qRT-PCR HSCR and normal bowel tissues suppression of cir-ZNF609 inhibited the proliferation and migration of cells. cir-ZNF609 took part in the onset of HSCR through the crosstalk with AKT3 by competing for shared miR-150-5p. loss of function 293T cells and SH-SY5Y cells miR-150-5p circRNA-miRNA 293T cells and SH-SY5Y cells luciferase reporter assay, RIP RNA immunoprecipitation and luciferase reporter assays demonstrated that cir-ZNF609 may act as a sponge for miR-150-5p to modulate the expression of AKT3. AKT3 circGFRA1 circRNA homo sapiens GFRA1 triple negative breast cancer 29037220 circGFRA1 and GFRA1 act as ceRNAs in triple negative breast cancer by regulating miR-34a. He R, Liu P, Xie X, Zhou Y, Liao Q, Xiong W, Li X, Li G, Zeng Z, Tang H. J Exp Clin Cancer Res. 2017 circGFRA1 was upregulated especially in TNBC cell lines (including BT-20, BT549, MDA-MB-468 and MDA-MB-231). microarray, qRT-PCR Tumor and paired adjacent normal mammal tissues from TNBC patients. HCC adjacent normal tissues, SKBR3, T47D, BT474, MCF-7, BT-483, BT-20, BT549, MDA-MB-468, MDA-MB-231, MCF10A and 184A1 circGFRA1 correlated with poor clinical outcomes in TNBC. Knockdown of circGFRA1 inhibits proliferation and promotes apoptosis in TNBC. loss of function BT549, MDA-MB-468 and MDA-MB-231). 4-week old female BALB/c nude mice Tumor tissues from TNBC patients miR-34a circRNA-miRNA BT549, MDA-MB-468 and MDA-MB-231). luciferase reporter assay, RIP In line with luciferase assays, our data confirmed that circGFRA1 functionally interacts with miR-34a and serves as a sponge for miR-34a. GFRA1 circGFRA1 and GFRA1 act as ceRNAs in TNBC through regulation of miR-34a circ-ITCH circRNA homo sapiens ITCH Bladder cancer 29386015 Circular RNA circ-ITCH inhibits bladder cancer progression by sponging miR-17/miR-224 and regulating p21, PTEN expression. Yang C, Yuan W, Yang X, Li P, Wang J, Han J, Tao J, Li P, Yang H, Lv Q, Zhang W. Mol Cancer. 2018 circ-ITCH is down-regulated in BCa tissues and cell lines. qRT-PCR BCa tumor and normal tissues, EJ and T24 cells Circ-ITCH inhibited the progression of BCa cells in vitro. circ-ITCH suppressed growth of xenografted tumor in vivo. gain of function EJ and T24 cells 4¨C6 weeks old female athymic BALB/C nude mice miR-17 and miR-224 circRNA-miRNA EJ and T24 cells luciferase reporter assay, RNA FISH circ-ITCH could directly sponge miR-17 and miR-224. p21 and PTEN circACTA2 circRNA homo sapiens ACTA2 28698179 A Novel Regulatory Mechanism of Smooth Muscle α-Actin Expression by NRG-1/circACTA2/miR-548f-5p Axis. Sun Y, Yang Z, Zheng B, Zhang XH, Zhang ML, Zhao XS, Zhao HY, Suzuki T, Wen JK. Circ Res. 2017 The Nrg-1-ICD induced circular ACTA2 (alpha-actin-2; circACTA2) formation by recruitment of the zinc-finger transcription factor IKZF1 (IKAROS family zinc finger 1) to the first intron of ¦Á-SMA gene. northern blots, qRT-PCR HASMCs (human aortic smooth muscle cells), MASMCs (mouse aortic vascular smooth muscle cells), RASMCs (rat aortic smooth muscle cells), HCMECs (human cardiac microvascular endothelial cells), VSMCs circACTA2 mediates NRG-1-ICD regulation of ¦Á-SMA expression in HASMCs via the NRG-1-ICD/circACTA2/miR-548f-5p axis. loss of function HASMCs 8- to 12-week-old male wild-type C57BL/6 mice miR-548f-5p circRNA-miRNA 293A, HASMCs luciferase reporter assay, RNA pull-down, FISH Luciferase assay revealed that miR-548f-5p mimic significantly decreased luciferase activity mediated by wild-type circACTA2 sequence but not its mutant. We used biotin-labeled circACTA2 probe to pull down microRNA(s) complementary to circACTA2 sequences and revealed a 20-fold enrichment of miR-548f-5p in the circACTA2 pulled down sediments. The results of RNA in situ hybridization were consistent with interactions between circACTA2 and miR-548f-5p. ¦Á-SMA NRG-1-ICD induces circACTA2 expression circ-TTBK2 circRNA homo sapiens TTBK2 Glioma 28219405 TTBK2 circular RNA promotes glioma malignancy by regulating miR-217/HNF1β/Derlin-1 pathway. Zheng J, Liu X, Xue Y, Gong W, Ma J, Xi Z, Que Z, Liu Y. J Hematol Oncol. 2017 upregulated in glioma FISH, qRT-PCR NBTs (normal brain tissues) (n = 11), grade I (n = 19), grade II (n = 19), grade III (n = 19), grade IV (n = 19) glioma tissues, NHA, U87, and U251 cells Enhanced expression of circ-TTBK2 promoted cell proliferation, migration, and invasion, while inhibited apoptosis. U251, U87 nude mice miR-217 circRNA-miRNA HEK293T, U87, U251 luciferase reports and RNA immunoprecipitation The luciferase activity in the circ-TTBK2-Wt+miR-217 group was significantly decreased than that in the circ-TTBK2-Wt+miR-217-NC group, while the luciferase activity in the circ-TTBK2-Mut+miR-217 group was not changed. The relative enrichment levels of circ-TTBK2 and miR-217 were both increased in the anti-Ago2 group than those in the anti-normal group. HNF1¦Â circ_0002198 circRNA homo sapiens ovarian endometriosis 29483390 Identification of Circular RNAs as a Novel Biomarker for Ovarian Endometriosis. Xu XX, Jia SZ, Dai Y, Zhang JJ, Li XY, Shi JH, Leng JH, Lang JH. Chin Med J (Engl). 2018 Upregulated in eutopic endometrium of patients with endometriosis. microarray, qRT-PCR control endometrium and eutopic endometrium miR455 3p, miR876 3p, miR661 and miR323a 5p circRNA-miRNA predicted miR455 3p, miR876 3p, miR661, and miR323a 5p were found to be the common targets of both circ_0004712 and circ_0002198. circ_0004712 circRNA homo sapiens ovarian endometriosis 29483390 Identification of Circular RNAs as a Novel Biomarker for Ovarian Endometriosis. Xu XX, Jia SZ, Dai Y, Zhang JJ, Li XY, Shi JH, Leng JH, Lang JH. Chin Med J (Engl). 2018 Upregulated in eutopic endometrium of patients with endometriosis. microarray, qRT-PCR control endometrium and eutopic endometrium miR455 3p, miR876 3p, miR661 and miR323a 5p circRNA-miRNA predicted miR455 3p, miR876 3p, miR661, and miR323a 5p were found to be the common targets of both circ_0004712 and circ_0002198. hsa_circRNA_100933 circRNA homo sapiens infantile hemangioma 29095957 Circular RNA profile of infantile hemangioma by microarray analysis. Fu C, Lv R, Xu G, Zhang L, Bi J, Lin L, Liu X, Huo R. PLoS One. 2017 up-regulated in IH compared to adjacent skin tissues. microarray, qRT-PCR IH and adjacent skin tissues miR-1298-3p, miR-892b, miR-2113, and miR-137, miR-514a-5p circRNA-miRNA predicted The potential MREs of hsa_circRNA_100933 were miR-1298-3p, miR-892b, miR-2113, and miR-137, miR-514a-5p. hsa_circRNA_104310 circRNA homo sapiens infantile hemangioma 29095957 Circular RNA profile of infantile hemangioma by microarray analysis. Fu C, Lv R, Xu G, Zhang L, Bi J, Lin L, Liu X, Huo R. PLoS One. 2017 down-regulated in IH compared to adjacent skin tissues. microarray, qRT-PCR IH and adjacent skin tissues miR-499a-3p, miR-1271-3p, miR-216a-3p, miR-197-3p, and miR-489-3p circRNA-miRNA predicted The potential MREs of hsa_circRNA_104310 included miR-499a-3p, miR-1271-3p, miR-216a-3p, miR-197-3p, and miR-489-3p circHIPK3 circRNA homo sapiens HIPK3 Diabetes Mellitus 29396373 Circular RNAs as novel regulators of β-cell functions in normal and disease conditions. Stoll L, Sobel J, Rodriguez-Trejo A, Guay C, Lee K, Venø MT, Kjems J, Laybutt DR, Regazzi R. Mol Metab. 2018 We indeed detected circHIPK3 in the insulin-secreting cell lines INS832/13, and MIN6B1, as well as, in mouse, rat, and human islets. RNA-seq, microarray, qRT-PCR INS832/13, MIN6B1, mouse islets, ratislets, human islets. We efficiently silenced circHIPK3 in both MIN6B1 cells and rat islets, resulting in an increase in apoptosis and in a negative impact on the proliferative capacity of the cells. Indeed, prolactin failed to stimulate proliferation of MIN6B1 and primary beta-cells containing lower levels of this circRNA. Furthermore, upon silencing of circHIPK3, insulin secretion in response to glucose was impaired and Insulin mRNA levels were significantly lower.This resulted in a decrease in insulin content in MIN6B1 cells, but not in rat islets. circHIPK3 regulates glucose-stimulated insulin secretion, insulin biosynthesis, proliferation, and apoptosis by affecting the expression of key genes associated with these functions. loss of function MIN6B1 cells primary rat beta-cells miR-124-3p and miR-338-3p circRNA-miRNA predicted These data indicate that the gene expression changes observed upon circHIPK3 silencing could at least partly be mediated by increasing the repressive activity of a group of miRNAs that control the functions of beta-cells, including miR-124-3p and miR-338-3p. circHLA-C circRNA homo sapiens HLA-C Lupus Nephritis 29499937 circHLA-C Plays an Important Role in Lupus Nephritis by Sponging miR-150. Luan J, Jiao C, Kong W, Fu J, Qu W, Chen Y, Zhu X, Zeng Y, Guo G, Qi H, Yao L, Pi J, Wang L, Zhou H. Mol Ther Nucleic Acids. 2018 Significantly upregulated in LN renal biopsies compared with NC kidneys. circHLA-C positively correlated with total proteinuria excretion per day (R = 0.920, p = 0.009), serum creatinine levels (R = 0.756, p = 0.082), percentage of crescentic glomeruli in total glomeruli (R = 0.929, p = 0.6007), and renal active index (AI) scores (R = 0.884, p = 0.020). RNA-seq, qRT-PCR lupus nephritis renal biopsies and negtive control kidneys miR-150 circRNA-miRNA predicted circHLA-C had a perfect match sequence (7-mer-m8 seed type) to bind miR-150. circRNA 0023115 circRNA homo sapiens ovarian endometriosis 29334789 Circular RNA expression in ovarian endometriosis. Shen L, Zhang Y, Zhou W, Peng Z, Hong X, Zhang Y. Epigenomics. 2018 Significantly lower expressed in ovarian endometriomas compared with eutopic endometrium microarray, qRT-PCR paired ovarian endometriomas and eutopic endometrium miR-940 circRNA-miRNA predicted circ-0023115 is ceRNA of miR-940 targeting ICAM-1 and ITGAL. ICAM-1, ITGAL hsa-circ-0005870 circRNA homo sapiens hypertensive 28534714 Profiling and bioinformatics analyses reveal differential circular RNA expression in hypertensive patients. Wu N, Jin L, Cai J. Clin Exp Hypertens. 2017 hsa-circ-0005870 exhibited significant downregulation in hypertensive patients. microarray, qRT-PCR plasma of hypertension patients and controls hsa-miR-6807-3p, hsa-miR-5095, hsa-miR-1273g-3p, hsa-miR-5096, hsa-miR-619-5p circRNA-miRNA predicted hsa:circ_101471 circRNA homo sapiens systemic lupus erythematosus 29360436 Comprehensive circular RNA profiles in plasma reveals that circular RNAs can be used as novel biomarkers for systemic lupus erythematosus. Li H, Li K, Lai W, Li X, Wang H, Yang J, Chu S, Wang H, Kang C, Qiu Y. Clin Chim Acta. 2018 Significantly higher in SLE patients than in corresponding normal subjects microarray, qRT-PCR plasma of SLE patients and normal subjects. hsa-miR-136-5p, hsa-miR-665, hsa-miR-486-3p, hsa-miR-601 and hsa-miR-30b-3p circRNA-miRNA predicted The potential miRNA targets of hsa:circ_101471 include hsa-miR-136-5p, hsa-miR-665, hsa-miR-486-3p, hsa-miR-601 and hsa-miR-30b-3p. hsa:circ_100226 circRNA homo sapiens systemic lupus erythematosus 29360436 Comprehensive circular RNA profiles in plasma reveals that circular RNAs can be used as novel biomarkers for systemic lupus erythematosus. Li H, Li K, Lai W, Li X, Wang H, Yang J, Chu S, Wang H, Kang C, Qiu Y. Clin Chim Acta. 2018 Significantly lower in SLE patients than in corresponding normal subjects microarray, qRT-PCR plasma of SLE patients and normal subjects. hsa-miR-138-5p, hsa-miR-145-3p,hsa-miR-24-3p, hsa-miR-620 and hsa-miR-875-3p circRNA-miRNA predicted For the underexpressed circRNA hsa:circ_100226, the potential miRNA targets include hsa-miR-138-5p, hsa-miR-145-3p, hsa-miR-24-3p, hsa-miR-620 and hsa-miR-875-3p. hsa:circ_400011 circRNA homo sapiens systemic lupus erythematosus 29360436 Comprehensive circular RNA profiles in plasma reveals that circular RNAs can be used as novel biomarkers for systemic lupus erythematosus. Li H, Li K, Lai W, Li X, Wang H, Yang J, Chu S, Wang H, Kang C, Qiu Y. Clin Chim Acta. 2018 Significantly higher in SLE patients than in corresponding normal subjects microarray, qRT-PCR plasma of SLE patients and normal subjects. hsa-miR-296-3p, hsa-miR-146b-3p, hsa-miR-181d-3p, hsa-miR-504-3p and hsa-miR-328-5p circRNA-miRNA predicted For hsa:circ_400011, the potential miRNA targets include hsa-miR-296-3p, hsa-miR-146b-3p, hsa-miR-181d-3p, hsa-miR-504-3p and hsa-miR-328-5p. hsa:-circ_102584 circRNA homo sapiens systemic lupus erythematosus 29360436 Comprehensive circular RNA profiles in plasma reveals that circular RNAs can be used as novel biomarkers for systemic lupus erythematosus. Li H, Li K, Lai W, Li X, Wang H, Yang J, Chu S, Wang H, Kang C, Qiu Y. Clin Chim Acta. 2018 Significantly higher in SLE patients than in corresponding normal subjects microarray, qRT-PCR plasma of SLE patients and normal subjects. hsa-miR-766-3p, hsa-miR-762, hsa-miR-412-3p, hsa-let-7i-3p and hsamiR-431-3p circRNA-miRNA predicted For hsa:circ_102584, the potential miRNA targets include hsa-miR-766-3p, hsa-miR-762, hsa-miR-412-3p, hsa-let-7i-3p and hsamiR-431-3p. hsa_circRNA_104268 circRNA homo sapiens hsa_circ_0078738 papillary thyroid carcinoma 28288173 Microarray profiling of circular RNAs in human papillary thyroid carcinoma. Peng N, Shi L, Zhang Q, Hu Y, Wang N, Ye H. PLoS One. 2017 upregulated microarray, qRT-PCR PTC tumors, matching contralateral normal samples, benign thyroid lesions (i.e., follicular adenoma samples and multinodular goiter samples) hsa-miR-324-3p, hsa-miR-660-3p, hsa-miR-646, hsa-miR-214-3p, hsa-miR-628-5p circRNA-miRNA predicted hsa_circRNA_104348 circRNA homo sapiens hsa_circ_0079891 papillary thyroid carcinoma 28288173 Microarray profiling of circular RNAs in human papillary thyroid carcinoma. Peng N, Shi L, Zhang Q, Hu Y, Wang N, Ye H. PLoS One. 2017 downregulated microarray, qRT-PCR PTC tumors, matching contralateral normal samples, benign thyroid lesions (i.e., follicular adenoma samples and multinodular goiter samples) hsa-miR-519d-5p, hsa-miR-301a-3p, hsa-miR-611, hsa-miR-100-3p, hsa-miR-758-5p circRNA-miRNA predicted circ-DROSHA circRNA homo sapiens DROSHA Temporal Lobe Epilepsy 29428937 High-Throughput Data of Circular RNA Profiles in Human Temporal Cortex Tissue Reveals Novel Insights into Temporal Lobe Epilepsy. Li J, Lin H, Sun Z, Kong G, Yan X, Wang Y, Wang X, Wen Y, Liu X, Zheng H, Jia M, Shi Z, Xu R, Yang S, Yuan F. Cell Physiol Biochem. 2018 Significantly down-regulated in the Temporal Lobe Epilepsy (TLE) group compared with those in the control group. RNA-seq, qRT-PCR temporal cortices from the control and TLE groups miR-1252-5p, miR-651-3p, miR-4446-5p, miR-548ab and miR-4762-3p circRNA-miRNA predicted miRNA seed sequence matching predicted that the top 5 predicted miRNAs of circ-DROSHA were miR-1252-5p, miR-651-3p, miR-4446-5p, miR-548ab and miR-4762-3p. circ-EFCAB2 circRNA homo sapiens EFCAB2 Temporal Lobe Epilepsy 29428937 High-Throughput Data of Circular RNA Profiles in Human Temporal Cortex Tissue Reveals Novel Insights into Temporal Lobe Epilepsy. Li J, Lin H, Sun Z, Kong G, Yan X, Wang Y, Wang X, Wen Y, Liu X, Zheng H, Jia M, Shi Z, Xu R, Yang S, Yuan F. Cell Physiol Biochem. 2018 Significantly up-regulated in the Temporal Lobe Epilepsy (TLE) group compared with those in the control group. RNA-seq, qRT-PCR temporal cortices from the control and TLE groups miR-5787, miR-6884-5p, miR-3929, miR-6780a-5p and miR-4739 circRNA-miRNA predicted miRNA seed sequence matching predicted that the top 5 predicted miRNAs of circ-EFCAB2 were miR-5787, miR-6884-5p, miR-3929, miR-6780a-5p, and miR-4739. circRNAs-MSR circRNA homo sapiens MSR circRNA_100226 Human Cartilage Degradation of Osteoarthritis 28624198 Emerging Roles of circRNA Related to the Mechanical Stress in Human Cartilage Degradation of Osteoarthritis. Liu Q, Zhang X, Hu X, Yuan L, Cheng J, Jiang Y, Ao Y. Mol Ther Nucleic Acids. 2017 overexpressed in the damaged region compared with the intact region of the cartilage in OA microarray, qRT-PCR the damaged region and the intact region of the cartilage in OA circRNAs-MSR were silenced using small interfering RNA, and knockdown of circRNAs-MSR could suppress tumor necrosis factor alpha (TNF-alpha) expression and increase extracellular matrix (ECM) formation. Our results demonstrated that circRNAs-MSR regulated TNF-alpha expression and participated in the chondrocyte ECM degradation process loss of function Chondrocyte miR-875 circRNA-miRNA predicted The circRNA-MSR 3UTR sequence matched these miRNAs, and the TNF-a 3UTR matched miR-875. Thus, we identified a common miRNA (miR-875) for circRNA-MSR and TNF-alpha targets. TNF-alpha hsa-circRNA_003251 circRNA homo sapiens diabetes and depression 28779132 Relationships of circular RNA with diabetes and depression. Jiang G, Ma Y, An T, Pan Y, Mo F, Zhao D, Liu Y, Miao JN, Gu YJ, Wang Y, Gao SH. Sci Rep. 2017 Upregulated in T2DM with depression compared to T2DM (DM). microarray, qRT-PCR whole blood samples of T2DM with depression and T2DM (DM). hsa-miR-4753-3p, hsa-miR-301a-5p, hsa-miR-3191-5p, hsa-miR-6805-5p, and hsa-miR-761 circRNA-miRNA predicted hsa-circRNA_015115 circRNA homo sapiens diabetes and depression 28779132 Relationships of circular RNA with diabetes and depression. Jiang G, Ma Y, An T, Pan Y, Mo F, Zhao D, Liu Y, Miao JN, Gu YJ, Wang Y, Gao SH. Sci Rep. 2017 Upregulated in T2DM with depression compared to T3DM (DM). microarray, qRT-PCR whole blood samples of T2DM with depression and T3DM (DM). hsa-miR-6760-3p, hsa-miR-761, hsa-miR-6728-3p, hsa-miR-5693, hsa-miR-298, and hsa-miR-367-5p circRNA-miRNA predicted hsa-circRNA_100918 circRNA homo sapiens diabetes and depression 28779132 Relationships of circular RNA with diabetes and depression. Jiang G, Ma Y, An T, Pan Y, Mo F, Zhao D, Liu Y, Miao JN, Gu YJ, Wang Y, Gao SH. Sci Rep. 2017 Upregulated in T2DM with depression compared to T4DM (DM). microarray, qRT-PCR whole blood samples of T2DM with depression and T4DM (DM). hsa-miR-33b-5p, hsa-miR-33a-5p, hsa-miR-148a-5p, hsa-miR-502-5p, and hsa-miR-891b circRNA-miRNA predicted hsa-circRNA_005019 circRNA homo sapiens diabetes and depression 28779132 Relationships of circular RNA with diabetes and depression. Jiang G, Ma Y, An T, Pan Y, Mo F, Zhao D, Liu Y, Miao JN, Gu YJ, Wang Y, Gao SH. Sci Rep. 2017 Downregulated in T2DM with depression compared to T5DM (DM). microarray, qRT-PCR whole blood samples of T2DM with depression and T5DM (DM). hsa-miR-298, hsa-miR-3155a, hsa-miR-1306-5p, and hsa-miR-4460. circRNA-miRNA predicted has_circRNA_021412 circRNA homo sapiens Hepatic Steatosis 28717649 Circular RNA Profiling and Bioinformatic Modeling Identify Its Regulatory Role in Hepatic Steatosis. Guo XY, He CX, Wang YQ, Sun C, Li GM, Su Q, Pan Q, Fan JG. Biomed Res Int. 2017 hsa-miR-1972 circRNA-miRNA predicted circRNA-miRNA-mRNA network further identified the signaling cascade of circRNA_021412/miR-1972/LPIN1, which was characterized by decreased level of circRNA_021412 and miR-1972-based inhibition of LPIN1. LPIN1 circRNA BANP circRNA homo sapiens BANP 29197342 Identification and integrated analysis of differentially expressed lncRNAs and circRNAs reveal the potential ceRNA networks during PDLSC osteogenic differentiation. Gu X, Li M, Jin Y, Liu D, Wei F. BMC Genet. 2017 miR-34a, miR-146a circRNA-miRNA periodontal ligament stem cells predicted circRNA BANP and circRNA ITCH were predicted to combine with miRNA34a and miRNA146a. DUSP1, FAS, RAC1, PDGFRA, TGFBR2 and MYC circRNA ITCH circRNA homo sapiens ITCH 29197342 Identification and integrated analysis of differentially expressed lncRNAs and circRNAs reveal the potential ceRNA networks during PDLSC osteogenic differentiation. Gu X, Li M, Jin Y, Liu D, Wei F. BMC Genet. 2017 miR-34a, miR-146a circRNA-miRNA periodontal ligament stem cells predicted circRNA BANP and circRNA ITCH were predicted to combine with miRNA34a and miRNA146a. DUSP1, FAS, RAC1, PDGFRA, TGFBR2 and MYC circUBAP2 circRNA homo sapiens UBAP2 osteosarcoma 28977896 Increased circular RNA UBAP2 acts as a sponge of miR-143 to promote osteosarcoma progression. Zhang H, Wang G, Ding C, Liu P, Wang R, Ding W, Tong D, Wu D, Li C, Wei Q, Zhang X, Li D, Liu P, Cui H, Tang H, Ji F. Oncotarget. 2017 increased in osteosarcoma microarray, qRT-PCR Human osteosarcoma tumor tissues and matched adjacent normal tissues, hFOB, MG63 and U2OS Increased circUBAP2 expression is significantly correlated with the progression and prognosis of osteosarcoma patients. CircUBAP2 promotes osteosarcoma growth both in vitro and in vivo. CircUBAP2 inhibits osteosarcoma cell apoptosis by upregulating the expression of anti-apoptotic Bcl-2. gain of function MG63, U2OS BALB/c athymic nude mice osteosarcoma tumor tissues and matched adjacent normal tissues miR-143 circRNA-miRNA MG63 RIP We found a specific enrichment of miR-143 in the precipitates of circUBAP2, suggesting that miR-143 is the circUBAP2-associated miRNA in osteosarcoma cells. Bcl-2 circ-Amotl1 circRNA homo sapiens Amotl1 hsa_circ_0004214 cancer 28622299 A circular RNA promotes tumorigenesis by inducing c-myc nuclear translocation. Yang Q, Du WW, Wu N, Yang W, Awan FM, Fang L, Ma J, Li X, Zeng Y, Yang Z, Dong J, Khorshidi A, Yang BB. Cell Death Differ. 2017 highly expressed in patient tumor samples and cancer cell lines qRT-PCR specimens of patients with breast carcinoma, HaCaT, MCF-10A, MCF-7, SK-Br-3, HTB-126, MB-468, MB-231, H460, HeLa, JHH-1, U87 Circ-Amotl1 increased cell survival and colony formation. Expression of circ-Amotl1 increased cell proliferation. Expression of circ-Amotl1 enhanced tumor formation. circ-Amotl1 promoted nuclear translocation of c-myc. loss of function, gain of function MDA-MB-231, SK-BR-3 nude mice xenografts c-myc circRNA-protein MDA-MB-231 RNA immunoprecipitation It was noted that c-myc showed the greatest binding capacity to circ-Amotl1, suggesting a critical role of c-myc in mediating circ-Amotl1 functions. circHIAT1 circRNA homo sapiens HIAT1 clear cell renal cell carcinoma 28089832 Androgen receptor (AR) promotes clear cell renal cell carcinoma (ccRCC) migration and invasion via altering the circHIAT1/miR-195-5p/29a-3p/29c-3p/CDC42 signals. Wang K, Sun Y, Tao W, Fei X, Chang C. Cancer Lett. 2017 lower in ccRCCs qRT-PCR ccRCCs and adjacent normal tissues, OSRC-2, SW839, ACHN AR promotes metastasis of ccRCC via circHIAT1. AR enhances ccRCC cell migration and invasion via altering circHIAT1 expression. Lower circHIAT1 expression led to a worse prognosis in ccRCC patients. loss of function, gain of function OSRC-2, SW839, ACHN 6-8 weeks old nude mice ccRCCs and adjacent normal tissues miR-195-5p/29a-3p/29c-3p circRNA-miRNA OSRC-2 RNA pull-down overexpressed circHIAT1 absorbed more miR-195-5p/29a-3p/29c-3p compared with the control in SW-839 cells, while shcircHIAT1 in OSRC2 cells absorbed less miR-195-5p/29a-3p/29c-3p CDC42 Targeting AR could suppress ccRCC cell progression via increasing circHIAT1 expression. CircHIPK3 circRNA homo sapiens HIPK3 colorectal cancer 29549306 CircHIPK3 promotes colorectal cancer growth and metastasis by sponging miR-7. Zeng K, Chen X, Xu M, Liu X, Hu X, Xu T, Sun H, Pan Y, He B, Wang S. Cell Death Dis. 2018 CircHIPK3 is significantly upregulated in CRC qRT-PCR CRC cell lines (HCT116, HT29, SW480, SW620, DLD1), CRC tumor and matched normal tissues. Silencing of circHIPK3 inhibits CRC cells proliferation, migration, invasion, and induces apoptosis in vitro. Silencing of circHIPK3 combined with overexpression of miR-7 exhibits an additive inhibitory effect on CRC growth and metastasis in xenograft animal models. loss of function HCT116 and HT29 cells 5-week-old male BALB/c nude mice miR-7 circRNA-miRNA HCT116 and HT29 cells RNA pull-down qRT-PCR analyses revealed that miR-7 was the only one miRNA that was abundantly pulled down by circHIPK3 probe in both HCT116 and HT29 cells. FAK, IGF1R, EGFR, and YY1 circ-Foxo3 circRNA homo sapiens Foxo3 tumor 26657152 Foxo3 activity promoted by non-coding effects of circular RNA and Foxo3 pseudogene in the inhibition of tumor growth and angiogenesis. Yang W, Du WW, Li X, Yee AJ, Yang BB. Oncogene. 2016 Three noncancerous cell lines BEAS2B, HaCaT and MCF-10A all expressed high levels of circ-Foxo3. qRT-PCR, northern blots BEAS2B, HaCaT, MCF-10A, SK-Br3, HTB-126, MB-468, MB-231, LnCap, Du145 MDA-MB-231 cells transfected with circ-Foxo3 grew slower than the control vector-transfected cells did. We found that cells expressing circ-Foxo3 formed significantly smaller tumors than the control cells in vivo. gain of function MDA-MB-231 nude mice miR-22, miR-136*, miR-138, miR-149*, miR-433, miR-762, miR-3614¨C5p and miR-3622b¨C5p. circRNA-miRNA MDA-MB-231 RNA pull-down, luciferase reporter assay miR-22, miR-136*, miR-138, miR-149*, miR-433, miR-762, miR-3614¨C5p and miR-3622b¨C5p directly bind to circ-Foxo3. circANRIL circRNA homo sapiens ANRIL atherosclerosis 27539542 Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans. Holdt LM, Stahringer A, Sass K, Pichler G, Kulak NA, Wilfert W, Kohlmaier A, Herbst A, Northoff BH, Nicolaou A, Gäbel G, Beutner F, Scholz M, Thiery J, Musunuru K, Krohn K, Mann M, Teupser D. Nat Commun. 2016 CircANRIL was expressed in both healthy and diseased human vascular tissues, as well as smooth muscle cells (SMC) and monocyte/macrophages. qRT-PCR, FISH Liver, vein, plaques, aneurysms, HEK-293, MonoMac, primary arterial SMC and FB, EC, PBMC circANRIL confers atheroprotection by controlling ribosomal RNA (rRNA) maturation and modulating pathways of atherogenesis. loss of function, gain of function HEK293 PES1 and NOP14 circRNA-protein HEK-293 RNA pull-down, RIP Strongest binding was determined for nucleolar protein 14 (NOP14), which is involved in the formation of the nucleolar 40S ribosomal subunit24, and for pescadillo zebrafish homologue 1 (PES1), which is a component of the PES1¨CBOP1¨CWDR12 (PeBoW) complex. qPCR analysis after RIP revealed the interaction of circANRIL RNA with the PeBoW complex members PES1 and NOP14, where circANRIL binding to PES1 was the strongest interaction tested. circSMARCA5 circRNA homo sapiens SMARCA5 prostate cancer 28765045 Androgen-responsive circular RNA circSMARCA5 is up-regulated and promotes cell proliferation in prostate cancer. Kong Z, Wan X, Zhang Y, Zhang P, Zhang Y, Zhang X, Qi X, Wu H, Huang J, Li Y. Biochem Biophys Res Commun. 2017 circ-SMARCA5 was up-regulated in PCa tissues qRT-PCR 22RV1, DU145, PC-3, LNCaP and WPMY-1, prostate cancer and non-tumor tissue samples circ-SMARCA5 acted as an oncogenic circRNA to promote cell cycle progression. loss of function LNCaP-AI, DU145, PC3 Androgen treatment could induce circ-SMARCA5 expression cRYR2-4 circRNA homo sapiens RYR2 27531932 RBM20 Regulates Circular RNA Production From the Titin Gene. Khan MA, Reckman YJ, Aufiero S, van den Hoogenhof MM, van der Made I, Beqqali A, Koolbergen DR, Rasmussen TB, van der Velden J, Creemers EE, Pinto YM. Circ Res. 2016 expreseed in human tissues RNA-seq, RT-PCR adult muscle tissues (heart), fetal tissues (heart) cTECRL circRNA homo sapiens TECRL 27531932 RBM20 Regulates Circular RNA Production From the Titin Gene. Khan MA, Reckman YJ, Aufiero S, van den Hoogenhof MM, van der Made I, Beqqali A, Koolbergen DR, Rasmussen TB, van der Velden J, Creemers EE, Pinto YM. Circ Res. 2016 expreseed in human tissues RNA-seq, RT-PCR adult muscle tissues (skeletal, heart), fetal tissues (heart) cRYR2-3 circRNA homo sapiens RYR2 27531932 RBM20 Regulates Circular RNA Production From the Titin Gene. Khan MA, Reckman YJ, Aufiero S, van den Hoogenhof MM, van der Made I, Beqqali A, Koolbergen DR, Rasmussen TB, van der Velden J, Creemers EE, Pinto YM. Circ Res. 2016 expreseed in human tissues RNA-seq, RT-PCR adult non-muscle tissues (brain, thyroid, lung), adult muscle tissues (heart), fetal tissues (heart, brain) cN4B2L2 circRNA homo sapiens N4B2L2 27531932 RBM20 Regulates Circular RNA Production From the Titin Gene. Khan MA, Reckman YJ, Aufiero S, van den Hoogenhof MM, van der Made I, Beqqali A, Koolbergen DR, Rasmussen TB, van der Velden J, Creemers EE, Pinto YM. Circ Res. 2016 expreseed in human tissues RNA-seq, RT-PCR adult non-muscle tissues (brain, thyroid, lung), adult muscle tissues (intestine, uterus, skeletal, heart), fetal tissues (heart,brain) cSTRN circRNA homo sapiens STRN 27531932 RBM20 Regulates Circular RNA Production From the Titin Gene. Khan MA, Reckman YJ, Aufiero S, van den Hoogenhof MM, van der Made I, Beqqali A, Koolbergen DR, Rasmussen TB, van der Velden J, Creemers EE, Pinto YM. Circ Res. 2016 expreseed in human tissues RNA-seq, RT-PCR adult non-muscle tissues (brain, thyroid, lung), adult muscle tissues (stomach, intestine, uterus,skeletal, heart), fetal tissues (heart, brain) cPRDM5 circRNA homo sapiens PRDM5 27531932 RBM20 Regulates Circular RNA Production From the Titin Gene. Khan MA, Reckman YJ, Aufiero S, van den Hoogenhof MM, van der Made I, Beqqali A, Koolbergen DR, Rasmussen TB, van der Velden J, Creemers EE, Pinto YM. Circ Res. 2016 expreseed in human tissues RNA-seq, RT-PCR adult non-muscle tissues (brain, thyroid, lung), adult muscle tissues (stomach, intestine, uterus,skeletal, heart), fetal tissues (heart,liver, brain) cCCSER2 circRNA homo sapiens CCSER2 27531932 RBM20 Regulates Circular RNA Production From the Titin Gene. Khan MA, Reckman YJ, Aufiero S, van den Hoogenhof MM, van der Made I, Beqqali A, Koolbergen DR, Rasmussen TB, van der Velden J, Creemers EE, Pinto YM. Circ Res. 2016 expreseed in human tissues RNA-seq, RT-PCR adult non-muscle tissues (brain, thyroid, lung, kidney, liver), adult muscle tissues (stomach, intestine, uterus, skeletal, heart), fetal tissues (heart,liver, brain) cRAPGEF2 circRNA homo sapiens RAPGEF2 27531932 RBM20 Regulates Circular RNA Production From the Titin Gene. Khan MA, Reckman YJ, Aufiero S, van den Hoogenhof MM, van der Made I, Beqqali A, Koolbergen DR, Rasmussen TB, van der Velden J, Creemers EE, Pinto YM. Circ Res. 2016 expreseed in human tissues RNA-seq, RT-PCR adult non-muscle tissues (brain, thyroid, lung, kidney, liver), adult muscle tissues (stomach, intestine, uterus, skeletal, heart), fetal tissues (heart,liver, brain) cTMEM38B circRNA homo sapiens TMEM38B 27531932 RBM20 Regulates Circular RNA Production From the Titin Gene. Khan MA, Reckman YJ, Aufiero S, van den Hoogenhof MM, van der Made I, Beqqali A, Koolbergen DR, Rasmussen TB, van der Velden J, Creemers EE, Pinto YM. Circ Res. 2016 expreseed in human tissues RNA-seq, RT-PCR adult non-muscle tissues (brain, thyroid, lung, liver), adult muscle tissues (stomach, intestine, uterus, heart), fetal tissues (heart, brain) cUGP2 circRNA homo sapiens UGP2 27531932 RBM20 Regulates Circular RNA Production From the Titin Gene. Khan MA, Reckman YJ, Aufiero S, van den Hoogenhof MM, van der Made I, Beqqali A, Koolbergen DR, Rasmussen TB, van der Velden J, Creemers EE, Pinto YM. Circ Res. 2016 expreseed in human tissues RNA-seq, RT-PCR adult non-muscle tissues (brain, thyroid, lung, liver), adult muscle tissues (stomach, intestine, uterus, skeletal, heart), fetal tissues (heart, liver, brain) cATP2B4 circRNA homo sapiens ATP2B4 27531932 RBM20 Regulates Circular RNA Production From the Titin Gene. Khan MA, Reckman YJ, Aufiero S, van den Hoogenhof MM, van der Made I, Beqqali A, Koolbergen DR, Rasmussen TB, van der Velden J, Creemers EE, Pinto YM. Circ Res. 2016 expreseed in human tissues RNA-seq, RT-PCR adult non-muscle tissues (thyroid, lung), adult muscle tissues (stomach, intestine, uterus, heart), fetal tissues (heart, brain) cPDLIM5 circRNA homo sapiens PDLIM5 27531932 RBM20 Regulates Circular RNA Production From the Titin Gene. Khan MA, Reckman YJ, Aufiero S, van den Hoogenhof MM, van der Made I, Beqqali A, Koolbergen DR, Rasmussen TB, van der Velden J, Creemers EE, Pinto YM. Circ Res. 2016 expreseed in human tissues RNA-seq, RT-PCR adult non-muscle tissues (thyroid, lung, kidney, liver), adult muscle tissues (stomach, intestine, uterus, skeletal, heart), fetal tissues (heart,liver, brain) circular PVT1 circRNA homo sapiens PVT1 acute myeloid leukemia 29467491 MYC-containing amplicons in acute myeloid leukemia: genomic structures, evolution, and transcriptional consequences. L Abbate A, Tolomeo D, Cifola I, Severgnini M, Turchiano A, Augello B, Squeo G, D Addabbo P, Traversa D, Daniele G, Lonoce A, Pafundi M, Carella M, Palumbo O, Dolnik A, Muehlematter D, Schoumans J, Van Roy N, De Bellis G, Martinelli G, Merla G, Bullinger L, et al. Leukemia. 2018 strong upregulation of circPVT1 in AML-amp cases with amplicons including PVT1 compared with AML-amp cases in which PVT1 was not amplified (as 07B60) or AML-NK samples. In AML cell lines, a slight upregulation of circPVT1 was observed only in the two cell lines carrying more than five copies of PVT1 (GF-D8 and KG-1). qRT-PCR AML-amp cases with amplicons including PVT1, AML-amp cases in which PVT1 was not amplified, AML cases with a normal karyotype (AML-NK samples), GF-D8 and KG-1 circ AML1 Ex5-6-5 circRNA homo sapiens AML1 23527860 Identification of a novel circularized transcript of the AML1 gene. Xu AN, Chen XH, Tan YH, Qi XL, Xu ZF, Zhang LL, Ren FG, Bian SC, Chen Y, Wang HW. BMB Rep. 2013 a novel circularized transcript of the AML1 gene detected in AML RT-PCR, sanger sequencing an AML patient and a healthy individual f-circPR fusion circRNA homo sapiens PML-RARA fusion gene GTACACTGGCACGGGGTGTGCCCCGGGCACTGACTGTACCACAGCCATAGGCTGGGCTTCAGCCAGCCCCAGGGCCTGAACCTGGGCCTTCACTCTCTCTGCCTCCTCGGGCAGGATGTCCAGGCAGGCAGCCTTGAGGAGGGTGATCTGGTCGGCGATGGTGAGGGTGGTGAAGCCGGGCAGCTGCTTGGCGAACTCCACAGTCTTAATGATGCACTTGGTGGAGAGTTCACTGAACTTGTCCCAGAGGTCAATGTCCAGAGAGACACGTTGTTCTGAGCTGTTGTTCGTAGTGTATTTGCCCAGCTGGCAGAGGGCAGGGAAGGTTTCCTGGTGCGCTTTGCGCACCTTCTCAATGAGCTCCCCCACCTCCGGCGTCAGCGTGTAGCTCTCAGAGCACTCGGGCTTGGGCACCTCCTTCTTCTTCTTGTTTCGGTCGTTTCTCACAGACTCCTTGGACATGCCCACTTCAAAGCACTTCTGCAGTCGGCAGTACTGGCAGCGGTTCCGGGTCACCTTGTTGATGATGCAGTTCTTGTCCCGGTGACACGTGTACACCATGTTCTTCTGGATGCTGCGGCGGAAGAAGCCCTTGCAGCCCTCACAGGCGCTG acute promyelocytic leukemia 27040497 Oncogenic Role of Fusion-circRNAs Derived from Cancer-Associated Chromosomal Translocations. Guarnerio J, Bezzi M, Jeong JC, Paffenholz SV, Berry K, Naldini MM, Lo-Coco F, Tay Y, Beck AH, Pandolfi PP. Cell. 2016 f-circPR is expressed in bone marrow(BM)-derived leukemic cells of APL patients and in APL-derived leukemic cell line NB4. PCR products sequencing APL patients, NB4 cell line, MEFs f-circPR exerts tumor promoting activity in immortalized MEFs and is involved in the tumorigenic process independent of their linear transcript and their fusion protein counterparts. loss of function, gain of function APL patients, NB4 cell line, MEFs f-circPR isoform fusion circRNA homo sapiens PML-RARA fusion gene GTACACTGGCACGGGGTGTGCCCCGGGCACTGACTGTACCACAGCCATAGGCTGGGCTTCAGCCAGCCCCAGGGCCTGAACCTGGGCCTTCACTCTCTCTGCCTCCTCGGGCAGGTCAACGTCAATAGGGTCCCTGGGAGTGCTGGCAGCGGTTCCGGGTCACCTTGTTGATGATGCAGTTCTTGTCCCGGTGACACGTGTACACCATGTTCTTCTGGATGCTGCGGCGGAAGAAGCCCTTGCAGCCCTCACAGGCGCTGACCCCATAGTGGTAGCC acute promyelocytic leukemia 27040497 Oncogenic Role of Fusion-circRNAs Derived from Cancer-Associated Chromosomal Translocations. Guarnerio J, Bezzi M, Jeong JC, Paffenholz SV, Berry K, Naldini MM, Lo-Coco F, Tay Y, Beck AH, Pandolfi PP. Cell. 2016 The f-circPR isoform is expressed in bone marrow(BM)-derived leukemic cells of APL patients. PCR products sequencing APL patients, NB4 cell line, MEFs f-circPR exerts tumor promoting activity in immortalized MEFs and is involved in the tumorigenic process independent of their linear transcript and their fusion protein counterparts. loss of function, gain of function APL patients, NB4 cell line, MEFs circ_CDH1_9-10 circRNA homo sapiens CDH1 Luminal breast cancer 29581865 Luminal breast cancer-specific circular RNAs uncovered by a novel tool for data analysis. Tarrero LC, Ferrero G, Miano V, De Intinis C, Ricci L, Arigoni M, Riccardo F, Annaratone L, Castellano I, Calogero RA, Beccuti M, Cordero F, De Bortoli M. Oncotarget. 2018 highly expressed in tumor samples RNA-seq, qRT-PCR BC and the non-tumor tissues circ_CDYL_4 circRNA homo sapiens CDYL Luminal breast cancer 29581865 Luminal breast cancer-specific circular RNAs uncovered by a novel tool for data analysis. Tarrero LC, Ferrero G, Miano V, De Intinis C, Ricci L, Arigoni M, Riccardo F, Annaratone L, Castellano I, Calogero RA, Beccuti M, Cordero F, De Bortoli M. Oncotarget. 2018 highly expressed in tumor samples RNA-seq, qRT-PCR BC and the non-tumor tissues circ_ESR1_3-4 circRNA homo sapiens ESR1 Luminal breast cancer 29581865 Luminal breast cancer-specific circular RNAs uncovered by a novel tool for data analysis. Tarrero LC, Ferrero G, Miano V, De Intinis C, Ricci L, Arigoni M, Riccardo F, Annaratone L, Castellano I, Calogero RA, Beccuti M, Cordero F, De Bortoli M. Oncotarget. 2018 highly expressed in tumor samples RNA-seq, qRT-PCR BC and the non-tumor tissues circ_GFRA1_5-7 circRNA homo sapiens GFRA1 Luminal breast cancer 29581865 Luminal breast cancer-specific circular RNAs uncovered by a novel tool for data analysis. Tarrero LC, Ferrero G, Miano V, De Intinis C, Ricci L, Arigoni M, Riccardo F, Annaratone L, Castellano I, Calogero RA, Beccuti M, Cordero F, De Bortoli M. Oncotarget. 2018 highly expressed in tumor samples RNA-seq, qRT-PCR BC and the non-tumor tissues circ_HIPK3_2 circRNA homo sapiens HIPK3 Luminal breast cancer 29581865 Luminal breast cancer-specific circular RNAs uncovered by a novel tool for data analysis. Tarrero LC, Ferrero G, Miano V, De Intinis C, Ricci L, Arigoni M, Riccardo F, Annaratone L, Castellano I, Calogero RA, Beccuti M, Cordero F, De Bortoli M. Oncotarget. 2018 highly expressed in tumor samples RNA-seq, qRT-PCR BC and the non-tumor tissues circ_IGF1R_2 circRNA homo sapiens IGF1R Luminal breast cancer 29581865 Luminal breast cancer-specific circular RNAs uncovered by a novel tool for data analysis. Tarrero LC, Ferrero G, Miano V, De Intinis C, Ricci L, Arigoni M, Riccardo F, Annaratone L, Castellano I, Calogero RA, Beccuti M, Cordero F, De Bortoli M. Oncotarget. 2018 highly expressed in tumor samples RNA-seq, qRT-PCR BC and the non-tumor tissues circ_MAN1A2_2-5 circRNA homo sapiens MAN1A2 Luminal breast cancer 29581865 Luminal breast cancer-specific circular RNAs uncovered by a novel tool for data analysis. Tarrero LC, Ferrero G, Miano V, De Intinis C, Ricci L, Arigoni M, Riccardo F, Annaratone L, Castellano I, Calogero RA, Beccuti M, Cordero F, De Bortoli M. Oncotarget. 2018 highly expressed in tumor samples RNA-seq, qRT-PCR BC and the non-tumor tissues circ_NCOA3_4-9 circRNA homo sapiens NCOA3 Luminal breast cancer 29581865 Luminal breast cancer-specific circular RNAs uncovered by a novel tool for data analysis. Tarrero LC, Ferrero G, Miano V, De Intinis C, Ricci L, Arigoni M, Riccardo F, Annaratone L, Castellano I, Calogero RA, Beccuti M, Cordero F, De Bortoli M. Oncotarget. 2018 highly expressed in tumor samples RNA-seq, qRT-PCR BC and the non-tumor tissues circ_PGR_2-7 circRNA homo sapiens PGR Luminal breast cancer 29581865 Luminal breast cancer-specific circular RNAs uncovered by a novel tool for data analysis. Tarrero LC, Ferrero G, Miano V, De Intinis C, Ricci L, Arigoni M, Riccardo F, Annaratone L, Castellano I, Calogero RA, Beccuti M, Cordero F, De Bortoli M. Oncotarget. 2018 highly expressed in tumor samples RNA-seq, qRT-PCR BC and the non-tumor tissues circ_RELL1_4-6 circRNA homo sapiens RELL1 Luminal breast cancer 29581865 Luminal breast cancer-specific circular RNAs uncovered by a novel tool for data analysis. Tarrero LC, Ferrero G, Miano V, De Intinis C, Ricci L, Arigoni M, Riccardo F, Annaratone L, Castellano I, Calogero RA, Beccuti M, Cordero F, De Bortoli M. Oncotarget. 2018 highly expressed in tumor samples RNA-seq, qRT-PCR BC and the non-tumor tissues circVRK1 circRNA homo sapiens VRK1 breast cancer 29221160 Circular RNA profile indicates circular RNA VRK1 is negatively related with breast cancer stem cells. Yan N, Xu H, Zhang J, Xu L, Zhang Y, Zhang L, Xu Y, Zhang F. Oncotarget. 2017 a downregulated circRNA in BCSCs RNA-seq, qRT-PCR BCSCs and non-BCSCs, MCF-7 and MDA-MB-231 CircVRK1 displays a negative regulatory effect on self-renewal capacity, BCSCs¡¯ expansion and expression levels of stemness-related markers in vitro. loss of function MCF-7 and MDA-MB-231 cCDYL2 circRNA homo sapiens CDYL2 25543144 Exon circularization requires canonical splice signals. Starke S, Jost I, Rossbach O, Schneider T, Schreiner S, Hung LH, Bindereif A. Cell Rep. 2015 detected in BJ-T RT-PCR BJ-T cGLIS3 circRNA homo sapiens GLIS3 25543144 Exon circularization requires canonical splice signals. Starke S, Jost I, Rossbach O, Schneider T, Schreiner S, Hung LH, Bindereif A. Cell Rep. 2015 detected in BJ-T RT-PCR BJ-T cLPAR1 circRNA homo sapiens LPAR1 25543144 Exon circularization requires canonical splice signals. Starke S, Jost I, Rossbach O, Schneider T, Schreiner S, Hung LH, Bindereif A. Cell Rep. 2015 detected in BJ-T, HEK293 RT-PCR BJ-T, HEK293 cASAP1 circRNA homo sapiens ASAP1 25543144 Exon circularization requires canonical splice signals. Starke S, Jost I, Rossbach O, Schneider T, Schreiner S, Hung LH, Bindereif A. Cell Rep. 2015 detected in BJ-T, HEK293, HeLa RT-PCR BJ-T, HEK293, HeLa cASPH circRNA homo sapiens ASPH 25543144 Exon circularization requires canonical splice signals. Starke S, Jost I, Rossbach O, Schneider T, Schreiner S, Hung LH, Bindereif A. Cell Rep. 2015 detected in BJ-T, HEK293, HeLa RT-PCR BJ-T, HEK293, HeLa cCAMSAP1 circRNA homo sapiens CAMSAP1 25543144 Exon circularization requires canonical splice signals. Starke S, Jost I, Rossbach O, Schneider T, Schreiner S, Hung LH, Bindereif A. Cell Rep. 2015 detected in BJ-T, HEK293, HeLa RT-PCR BJ-T, HEK293, HeLa cCRKL circRNA homo sapiens CRKL 25543144 Exon circularization requires canonical splice signals. Starke S, Jost I, Rossbach O, Schneider T, Schreiner S, Hung LH, Bindereif A. Cell Rep. 2015 detected in BJ-T, HEK293, HeLa RT-PCR BJ-T, HEK293, HeLa cEPHB4 circRNA homo sapiens EPHB4 25543144 Exon circularization requires canonical splice signals. Starke S, Jost I, Rossbach O, Schneider T, Schreiner S, Hung LH, Bindereif A. Cell Rep. 2015 detected in BJ-T, HEK293, HeLa RT-PCR BJ-T, HEK293, HeLa cFARSA circRNA homo sapiens FARSA 25543144 Exon circularization requires canonical splice signals. Starke S, Jost I, Rossbach O, Schneider T, Schreiner S, Hung LH, Bindereif A. Cell Rep. 2015 detected in BJ-T, HEK293, HeLa RT-PCR BJ-T, HEK293, HeLa cGSE1 circRNA homo sapiens GSE1 25543144 Exon circularization requires canonical splice signals. Starke S, Jost I, Rossbach O, Schneider T, Schreiner S, Hung LH, Bindereif A. Cell Rep. 2015 detected in BJ-T, HEK293, HeLa RT-PCR BJ-T, HEK293, HeLa cHIPK3 circRNA homo sapiens HIPK3 25543144 Exon circularization requires canonical splice signals. Starke S, Jost I, Rossbach O, Schneider T, Schreiner S, Hung LH, Bindereif A. Cell Rep. 2015 detected in BJ-T, HEK293, HeLa RT-PCR BJ-T, HEK293, HeLa cAFAP1 circRNA homo sapiens AFAP1 25543144 Exon circularization requires canonical splice signals. Starke S, Jost I, Rossbach O, Schneider T, Schreiner S, Hung LH, Bindereif A. Cell Rep. 2015 detected in BJ-T, HeLa RT-PCR BJ-T, HeLa cSH3PXD2A circRNA homo sapiens SH3PXD2A 25543144 Exon circularization requires canonical splice signals. Starke S, Jost I, Rossbach O, Schneider T, Schreiner S, Hung LH, Bindereif A. Cell Rep. 2015 detected in BJ-T, HeLa RT-PCR BJ-T, HeLa chr9_74522734_74523039 circRNA homo sapiens bladder cancer 29558461 Molecular and Bioinformatics Analyses Identify 7 Circular RNAs Involved in Regulation of Oncogenic Transformation and Cell Proliferation in Human Bladder Cancer. Cai D, Liu Z, Kong G. Med Sci Monit. 2018 down microarray, qRT-PCR bladder carcinoma (high-grade and low-grade) with resection specimens containing adjacent normal bladder tissue chr22_28943661_28946139 circRNA homo sapiens bladder cancer 29558461 Molecular and Bioinformatics Analyses Identify 7 Circular RNAs Involved in Regulation of Oncogenic Transformation and Cell Proliferation in Human Bladder Cancer. Cai D, Liu Z, Kong G. Med Sci Monit. 2018 up microarray, qRT-PCR bladder carcinoma (high-grade and low-grade) with resection specimens containing adjacent normal bladder tissue chr5_158368701_158368987 circRNA homo sapiens bladder cancer 29558461 Molecular and Bioinformatics Analyses Identify 7 Circular RNAs Involved in Regulation of Oncogenic Transformation and Cell Proliferation in Human Bladder Cancer. Cai D, Liu Z, Kong G. Med Sci Monit. 2018 up microarray, qRT-PCR bladder carcinoma (high-grade and low-grade) with resection specimens containing adjacent normal bladder tissue circFAM169A circRNA homo sapiens FAM169A bladder cancer 27484176 Screening differential circular RNA expression profiles reveals the regulatory role of circTCF25-miR-103a-3p/miR-107-CDK6 pathway in bladder carcinoma. Zhong Z, Lv M, Chen J. Sci Rep. 2016 down in BC microarray, qRT-PCR bladder carcinoma tissue and matched para-carcinoma tissue circTRIM24 circRNA homo sapiens TRIM24 bladder cancer 27484176 Screening differential circular RNA expression profiles reveals the regulatory role of circTCF25-miR-103a-3p/miR-107-CDK6 pathway in bladder carcinoma. Zhong Z, Lv M, Chen J. Sci Rep. 2016 down in BC microarray, qRT-PCR bladder carcinoma tissue and matched para-carcinoma tissue circBC048201 circRNA homo sapiens Bladder cancer 27484176 Screening differential circular RNA expression profiles reveals the regulatory role of circTCF25-miR-103a-3p/miR-107-CDK6 pathway in bladder carcinoma. Zhong Z, Lv M, Chen J. Sci Rep. 2016 up in BC microarray, qRT-PCR bladder carcinoma tissue and matched para-carcinoma tissue circPTK2 circRNA homo sapiens PTK2 bladder cancer 27484176 Screening differential circular RNA expression profiles reveals the regulatory role of circTCF25-miR-103a-3p/miR-107-CDK6 pathway in bladder carcinoma. Zhong Z, Lv M, Chen J. Sci Rep. 2016 up in BC microarray, qRT-PCR bladder carcinoma tissue and matched para-carcinoma tissue circZFR circRNA homo sapiens ZFR bladder cancer 27484176 Screening differential circular RNA expression profiles reveals the regulatory role of circTCF25-miR-103a-3p/miR-107-CDK6 pathway in bladder carcinoma. Zhong Z, Lv M, Chen J. Sci Rep. 2016 up in BC microarray, qRT-PCR bladder carcinoma tissue and matched para-carcinoma tissue circRNA-001283 circRNA homo sapiens breast cancer 29431182 Comprehensive circular RNA profiling reveals the regulatory role of the circRNA-000911/miR-449a pathway in breast carcinogenesis. Wang H, Xiao Y, Wu L, Ma D. Int J Oncol. 2018 down microarray, qRT-PCR cancer tissues and paired adjacent non-cancerous tissues circRNA-001175 circRNA homo sapiens breast cancer 29431182 Comprehensive circular RNA profiling reveals the regulatory role of the circRNA-000911/miR-449a pathway in breast carcinogenesis. Wang H, Xiao Y, Wu L, Ma D. Int J Oncol. 2018 up microarray, qRT-PCR cancer tissues and paired adjacent non-cancerous tissues circRNA-100438 circRNA homo sapiens breast cancer 29431182 Comprehensive circular RNA profiling reveals the regulatory role of the circRNA-000911/miR-449a pathway in breast carcinogenesis. Wang H, Xiao Y, Wu L, Ma D. Int J Oncol. 2018 up microarray, qRT-PCR cancer tissues and paired adjacent non-cancerous tissues circular RNA100328 circRNA homo sapiens 26451160 Comprehensive circular RNA profiling reveals that circular RNA100783 is involved in chronic CD28-associated CD8(+)T cell ageing. Wang YH, Yu XH, Luo SS, Han H. Immun Ageing. 2015 expressed in cross-comparison between C1 and C4 microarray, qRT-PCR CD28(+)CD8(+) T cells and CD28(-)CD8(+)T cells circular RNA100550 circRNA homo sapiens 26451160 Comprehensive circular RNA profiling reveals that circular RNA100783 is involved in chronic CD28-associated CD8(+)T cell ageing. Wang YH, Yu XH, Luo SS, Han H. Immun Ageing. 2015 expressed in cross-comparison between C1 and C4 microarray, qRT-PCR CD28(+)CD8(+) T cells and CD28(-)CD8(+)T cells circular RNA100783 circRNA homo sapiens 26451160 Comprehensive circular RNA profiling reveals that circular RNA100783 is involved in chronic CD28-associated CD8(+)T cell ageing. Wang YH, Yu XH, Luo SS, Han H. Immun Ageing. 2015 expressed in cross-comparison between C1 and C4 microarray, qRT-PCR CD28(+)CD8(+) T cells and CD28(-)CD8(+)T cells circular RNA102592 circRNA homo sapiens 26451160 Comprehensive circular RNA profiling reveals that circular RNA100783 is involved in chronic CD28-associated CD8(+)T cell ageing. Wang YH, Yu XH, Luo SS, Han H. Immun Ageing. 2015 expressed in cross-comparison between C1 and C4 microarray, qRT-PCR CD28(+)CD8(+) T cells and CD28(-)CD8(+)T cells circ chr16:85667519-85667738 circRNA homo sapiens 25376581 The landscape of microRNA, Piwi-interacting RNA, and circular RNA in human saliva. Bahn JH, Zhang Q, Li F, Chan TM, Lin X, Kim Y, Wong DT, Xiao X. Clin Chem. 2015 detected in human saliva RNA-seq, RT-PCR, sanger sequencing, qRT-PCR cell-free saliva (CFS) circ chr2:224758950-224760347 circRNA homo sapiens 25376581 The landscape of microRNA, Piwi-interacting RNA, and circular RNA in human saliva. Bahn JH, Zhang Q, Li F, Chan TM, Lin X, Kim Y, Wong DT, Xiao X. Clin Chem. 2015 detected in human saliva RNA-seq, RT-PCR, sanger sequencing, qRT-PCR cell-free saliva (CFS) circ chr2:64083439-64085070 circRNA homo sapiens 25376581 The landscape of microRNA, Piwi-interacting RNA, and circular RNA in human saliva. Bahn JH, Zhang Q, Li F, Chan TM, Lin X, Kim Y, Wong DT, Xiao X. Clin Chem. 2015 detected in human saliva RNA-seq, RT-PCR, sanger sequencing, qRT-PCR cell-free saliva (CFS) circ chr20:30954186-30956926 circRNA homo sapiens 25376581 The landscape of microRNA, Piwi-interacting RNA, and circular RNA in human saliva. Bahn JH, Zhang Q, Li F, Chan TM, Lin X, Kim Y, Wong DT, Xiao X. Clin Chem. 2015 detected in human saliva RNA-seq, RT-PCR, sanger sequencing, qRT-PCR cell-free saliva (CFS) circ chr21:37619814-37620866 circRNA homo sapiens 25376581 The landscape of microRNA, Piwi-interacting RNA, and circular RNA in human saliva. Bahn JH, Zhang Q, Li F, Chan TM, Lin X, Kim Y, Wong DT, Xiao X. Clin Chem. 2015 detected in human saliva RNA-seq, RT-PCR, sanger sequencing, qRT-PCR cell-free saliva (CFS) circ chr8:109304599-109304662 circRNA homo sapiens 25376581 The landscape of microRNA, Piwi-interacting RNA, and circular RNA in human saliva. Bahn JH, Zhang Q, Li F, Chan TM, Lin X, Kim Y, Wong DT, Xiao X. Clin Chem. 2015 detected in human saliva RNA-seq, RT-PCR, sanger sequencing, qRT-PCR cell-free saliva (CFS) circ chr8:20979041-20979113 circRNA homo sapiens 25376581 The landscape of microRNA, Piwi-interacting RNA, and circular RNA in human saliva. Bahn JH, Zhang Q, Li F, Chan TM, Lin X, Kim Y, Wong DT, Xiao X. Clin Chem. 2015 detected in human saliva RNA-seq, RT-PCR, sanger sequencing, qRT-PCR cell-free saliva (CFS) circ chr9:33971648-33973235 circRNA homo sapiens 25376581 The landscape of microRNA, Piwi-interacting RNA, and circular RNA in human saliva. Bahn JH, Zhang Q, Li F, Chan TM, Lin X, Kim Y, Wong DT, Xiao X. Clin Chem. 2015 detected in human saliva RNA-seq, RT-PCR, sanger sequencing, qRT-PCR cell-free saliva (CFS) ZKSCAN1 circular RNA circRNA homo sapiens ZKSCAN1 25281217 Short intronic repeat sequences facilitate circular RNA production. Liang D, Wilusz JE. Genes Dev. 2014 The human ZKSCAN1 gene produces an abundant circular RNA. northern blots, RT-PCR cerebellum, whole brain, fetal brain, liver, Huh7 circSGMS1_2-6 circRNA homo sapiens SGMS1 KP710931 CATATTTAGTCATTCATTTTTGATCAGGAGAAAGAAGACAGCCATCATTTGAAAGGTAAAGCTTCAGCGACTGAAGGAGTGTGGACTTTTTGAATTTCAAGAACAGTAAAGTTGGAACACAGCAGAGGGTGTGTAATAAAATACAGATTGGAAAGAAGACTGATGAAGAAAAATAACAGCATGATTCAGGCACACCATTGAGTTCTTTGGGATGCCCGAAAGTGTCTGGTTGGGAAACATGAAATAGAAGACGAGAACCTGCCTCAGCAAGCGTACCTGAGAATACTTTTAAAGGAACCTGTTGATAAATGCAAAACAGTGGCTGTTGCAGGTGATGGAACTGTACTGGAACAATGGGAGAAGCTGGTAGCTTATAGGAAGCCAAGATGACCAGAATGTTTTTAAATAATCCCGTGACGACAGCATGTACGATCCCTGAATGGGCCCGTGGG sphingomyelin synthase activity 29454087 Multi-step splicing of sphingomyelin synthase linear and circular RNAs. Filippenkov IB, Sudarkina OY, Limborska SA, Dergunova LV. Gene. 2018 As a control of RNA concentration in the R+ and R fractions, we used primers F6/R2 to characterize the level of the circRNA circSGMS1_2-6 (GenBank: KP710931). RT-PCR cortex renis, spleen, placenta, med. Oblongata, Sub. nigra, frontal cortex, blood, cerebellum, corpus callosum, hippocampus, lobus parietalis and thalamus. circSGMS1_2-3-3d circRNA homo sapiens SGMS1 KX061765 GGAGAAAGAAGACAGCCATCATTTGAAAGGTAAAGCTTCAGCGACTGAAGGAGTGTGGACTTTTTGAATTTCAAGAACAGTAAAGTTGGAACACAGCAGAGGGTGTGTAATAAAATACAGGTCAGAGCCTGGTCCAAAAGGTATAGAGAATTGGCAGTTACCCACAAGTCTGCCCCAAAGAGGTTCTTTCCAACCACCTGCCACACGTGACGACAGCATGTACGATCCCTGAATGGGCCCGTGGGCATATTTAGTCATTCATTTTTGATCA sphingomyelin synthase activity 29454087 Multi-step splicing of sphingomyelin synthase linear and circular RNAs. Filippenkov IB, Sudarkina OY, Limborska SA, Dergunova LV. Gene. 2018 An analysis of the presence of circSGMS1_2-3-3d in various human tissues was performed by RT¨CPCR using primers F3d/R3 and F5c/R5. circSGMS1_2-3-3d was detected in cortex renis, spleen, placenta, med. Oblongata, Sub. nigra, frontal cortex, cerebellum, corpus callosum, hippocampus, lobus parietalis and thalamus, not detected in white blood cells. RT-PCR cortex renis, spleen, placenta, med. Oblongata, Sub. nigra, frontal cortex, blood, cerebellum, corpus callosum, hippocampus, lobus parietalis and thalamus. circSGMS1_4-5c-6 circRNA homo sapiens SGMS1 KX061766 TGGTAGCTTATAGGAAGCCAAGATGACCAGAATGTTTTTAAATAATCCATTGGAAAGAAGACTGATGAAGAAAAATAACAGCATGATTCAGGCACACCATTGAGTTCTTTGGGATGCCCGAAAGTGTCTGGTTGGGAAACATGAAATAGAAGACGAGAACCTGCCTCAGCAAGCGTACCTGAGAATACTTTTAAAGGAACCTGTTGATAAATGCAAAACAGTGGCTGTTGCAGCCAGTCCCTCCATTTGGGGTCCCTGACTTCCCGCAACATTTGTGGACACAAGTTCACAAGTTTTCATGTCTTTTGAGTGTGTTCTTAGAAGTATATTATTGGGTGATGGAACTGTACTGGAACAATGGGAGAAGC sphingomyelin synthase activity 29454087 Multi-step splicing of sphingomyelin synthase linear and circular RNAs. Filippenkov IB, Sudarkina OY, Limborska SA, Dergunova LV. Gene. 2018 An analysis of the presence of circSGMS1_4-5c-6 in various human tissues was performed by RT¨CPCR using primers F3d/R3 and F5c/R5. circSGMS1_4-5c-6 was detected in placenta, med. Oblongata, Sub. nigra, frontal cortex, blood, corpus callosum, hippocampus and thalamus, present at an extremely low level in the cortex renis, spleen, cerebellum and lobus parietalis. RT-PCR cortex renis, spleen, placenta, med. Oblongata, Sub. nigra, frontal cortex, blood, cerebellum, corpus callosum, hippocampus, lobus parietalis and thalamus. circRNA0003906 circRNA homo sapiens Colorectal cancer 29123417 The expression profile and clinical significance of circRNA0003906 in colorectal cancer. Zhuo F, Lin H, Chen Z, Huang Z, Hu J. Onco Targets Ther. 2017 downregulated qRT-PCR CRC tissues and matched nontumor tissues, NCM460, SW480, SW620, HCT8, HCT116, HT29, and LoVo Compared with the high circRNA0003906-expression group, the low circRNA0003906-expression group exhibited a significantly higher incidence of poor differentiation (P=0.026) and lymphatic metastasis (N classification) (P,0.001). The area under the ROC curve was up to 0.818 (95% confidence interval =0.749¨C0.888; P,0.001). CRC tissues and matched nontumor tissues circ-MAN1A2 circRNA homo sapiens MAN1A2 Colorectal Cancer 27892494 Circular RNAs are down-regulated in KRAS mutant colon cancer cells and can be transferred to exosomes. Dou Y, Cha DJ, Franklin JL, Higginbotham JN, Jeppesen DK, Weaver AM, Prasad N, Levy S, Coffey RJ, Patton JG, Zhang B. Sci Rep. 2016 down-regulated in KRAS mutant colon cancer cells RNA-seq, qRT-PCR DKs-8, DLD-1, DKO-1, HKe3, HCT116 circ-RHOBTB3 circRNA homo sapiens RHOBTB3 Colorectal Cancer 27892494 Circular RNAs are down-regulated in KRAS mutant colon cancer cells and can be transferred to exosomes. Dou Y, Cha DJ, Franklin JL, Higginbotham JN, Jeppesen DK, Weaver AM, Prasad N, Levy S, Coffey RJ, Patton JG, Zhang B. Sci Rep. 2016 down-regulated in KRAS mutant colon cancer cells RNA-seq, qRT-PCR DKs-8, DLD-1, DKO-1, HKe3, HCT116 circ-ARHGAP5 circRNA homo sapiens ARHGAP5 Colorectal Cancer 27892494 Circular RNAs are down-regulated in KRAS mutant colon cancer cells and can be transferred to exosomes. Dou Y, Cha DJ, Franklin JL, Higginbotham JN, Jeppesen DK, Weaver AM, Prasad N, Levy S, Coffey RJ, Patton JG, Zhang B. Sci Rep. 2016 down-regulated in KRAS mutant colon cancer cells and can be transferred to exosomes RNA-seq, qRT-PCR DKs-8, DLD-1, DKO-1, HKe3, HCT116 and their exosomes circ-FAT1 circRNA homo sapiens FAT1 Colorectal Cancer 27892494 Circular RNAs are down-regulated in KRAS mutant colon cancer cells and can be transferred to exosomes. Dou Y, Cha DJ, Franklin JL, Higginbotham JN, Jeppesen DK, Weaver AM, Prasad N, Levy S, Coffey RJ, Patton JG, Zhang B. Sci Rep. 2016 down-regulated in KRAS mutant colon cancer cells and can be transferred to exosomes RNA-seq, qRT-PCR DKs-8, DLD-1, DKO-1, HKe3, HCT116 and their exosomes circ-HIPK3 circRNA homo sapiens HIPK3 Colorectal Cancer 27892494 Circular RNAs are down-regulated in KRAS mutant colon cancer cells and can be transferred to exosomes. Dou Y, Cha DJ, Franklin JL, Higginbotham JN, Jeppesen DK, Weaver AM, Prasad N, Levy S, Coffey RJ, Patton JG, Zhang B. Sci Rep. 2016 down-regulated in KRAS mutant colon cancer cells and can be transferred to exosomes RNA-seq, qRT-PCR DKs-8, DLD-1, DKO-1, HKe3, HCT116 and their exosomes circ-RTN4 circRNA homo sapiens RTN4 Colorectal Cancer 27892494 Circular RNAs are down-regulated in KRAS mutant colon cancer cells and can be transferred to exosomes. Dou Y, Cha DJ, Franklin JL, Higginbotham JN, Jeppesen DK, Weaver AM, Prasad N, Levy S, Coffey RJ, Patton JG, Zhang B. Sci Rep. 2016 down-regulated in KRAS mutant colon cancer cells and can be transferred to exosomes RNA-seq, qRT-PCR DKs-8, DLD-1, DKO-1, HKe3, HCT116 and their exosomes circ-SMARCA5 circRNA homo sapiens SMARCA5 Colorectal Cancer 27892494 Circular RNAs are down-regulated in KRAS mutant colon cancer cells and can be transferred to exosomes. Dou Y, Cha DJ, Franklin JL, Higginbotham JN, Jeppesen DK, Weaver AM, Prasad N, Levy S, Coffey RJ, Patton JG, Zhang B. Sci Rep. 2016 down-regulated in KRAS mutant colon cancer cells and can be transferred to exosomes RNA-seq, qRT-PCR DKs-8, DLD-1, DKO-1, HKe3, HCT116 and their exosomes hsa_circRNA_004183 circRNA homo sapiens repeated implantation failure 29132137 Altered Circular RNA Expression in Patients with Repeated Implantation Failure. Liu L, Li L, Ma X, Yue F, Wang Y, Wang L, Jin P, Zhang X. Cell Physiol Biochem. 2017 down-regulated in in endometrial biopsies taken from six women with repeated implantation failure compared to control group microarray, qRT-PCR endometrial biopsies taken from six women with repeated implantation failure and control group hsa_circRNA_044353 circRNA homo sapiens repeated implantation failure 29132137 Altered Circular RNA Expression in Patients with Repeated Implantation Failure. Liu L, Li L, Ma X, Yue F, Wang Y, Wang L, Jin P, Zhang X. Cell Physiol Biochem. 2017 down-regulated in in endometrial biopsies taken from six women with repeated implantation failure compared to control group microarray, qRT-PCR endometrial biopsies taken from six women with repeated implantation failure and control group hsa_circRNA_404686 circRNA homo sapiens repeated implantation failure 29132137 Altered Circular RNA Expression in Patients with Repeated Implantation Failure. Liu L, Li L, Ma X, Yue F, Wang Y, Wang L, Jin P, Zhang X. Cell Physiol Biochem. 2017 down-regulated in in endometrial biopsies taken from six women with repeated implantation failure compared to control group microarray, qRT-PCR endometrial biopsies taken from six women with repeated implantation failure and control group hsa_circRNA_070616 circRNA homo sapiens repeated implantation failure 29132137 Altered Circular RNA Expression in Patients with Repeated Implantation Failure. Liu L, Li L, Ma X, Yue F, Wang Y, Wang L, Jin P, Zhang X. Cell Physiol Biochem. 2017 up-regulated in in endometrial biopsies taken from six women with repeated implantation failure compared to control group microarray, qRT-PCR endometrial biopsies taken from six women with repeated implantation failure and control group hsa_circRNA_103716 circRNA homo sapiens repeated implantation failure 29132137 Altered Circular RNA Expression in Patients with Repeated Implantation Failure. Liu L, Li L, Ma X, Yue F, Wang Y, Wang L, Jin P, Zhang X. Cell Physiol Biochem. 2017 up-regulated in in endometrial biopsies taken from six women with repeated implantation failure compared to control group microarray, qRT-PCR endometrial biopsies taken from six women with repeated implantation failure and control group hsa_circRNA_104001 circRNA homo sapiens repeated implantation failure 29132137 Altered Circular RNA Expression in Patients with Repeated Implantation Failure. Liu L, Li L, Ma X, Yue F, Wang Y, Wang L, Jin P, Zhang X. Cell Physiol Biochem. 2017 up-regulated in in endometrial biopsies taken from six women with repeated implantation failure compared to control group microarray, qRT-PCR endometrial biopsies taken from six women with repeated implantation failure and control group hsa_circRNA_104854 circRNA homo sapiens repeated implantation failure 29132137 Altered Circular RNA Expression in Patients with Repeated Implantation Failure. Liu L, Li L, Ma X, Yue F, Wang Y, Wang L, Jin P, Zhang X. Cell Physiol Biochem. 2017 up-regulated in in endometrial biopsies taken from six women with repeated implantation failure compared to control group microarray, qRT-PCR endometrial biopsies taken from six women with repeated implantation failure and control group cASXL1 circRNA homo sapiens ASXL1 26076956 Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development. Szabo L, Morey R, Palpant NJ, Wang PL, Afari N, Jiang C, Parast MM, Murry CE, Laurent LC, Salzman J. Genome Biol. 2015 induction during fetal development RNA-seq, qRT-PCR fetal heart, fetal lung cCAMSAP1 circRNA homo sapiens CAMSAP1 26076956 Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development. Szabo L, Morey R, Palpant NJ, Wang PL, Afari N, Jiang C, Parast MM, Murry CE, Laurent LC, Salzman J. Genome Biol. 2015 induction during fetal development RNA-seq, qRT-PCR fetal heart, fetal lung cFAT3 circRNA homo sapiens FAT3 26076956 Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development. Szabo L, Morey R, Palpant NJ, Wang PL, Afari N, Jiang C, Parast MM, Murry CE, Laurent LC, Salzman J. Genome Biol. 2015 induction during fetal development RNA-seq, qRT-PCR fetal heart, fetal lung cHIPK3 circRNA homo sapiens HIPK3 26076956 Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development. Szabo L, Morey R, Palpant NJ, Wang PL, Afari N, Jiang C, Parast MM, Murry CE, Laurent LC, Salzman J. Genome Biol. 2015 induction during fetal development RNA-seq, qRT-PCR fetal heart, fetal lung cNCX1 circRNA homo sapiens NCX1 26076956 Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development. Szabo L, Morey R, Palpant NJ, Wang PL, Afari N, Jiang C, Parast MM, Murry CE, Laurent LC, Salzman J. Genome Biol. 2015 induction during fetal development RNA-seq, qRT-PCR fetal heart, fetal lung cRHOBTB3 circRNA homo sapiens RHOBTB3 26076956 Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development. Szabo L, Morey R, Palpant NJ, Wang PL, Afari N, Jiang C, Parast MM, Murry CE, Laurent LC, Salzman J. Genome Biol. 2015 induction during fetal development RNA-seq, qRT-PCR fetal heart, fetal lung cSETD3 circRNA homo sapiens SETD3 26076956 Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development. Szabo L, Morey R, Palpant NJ, Wang PL, Afari N, Jiang C, Parast MM, Murry CE, Laurent LC, Salzman J. Genome Biol. 2015 induction during fetal development RNA-seq, qRT-PCR fetal heart, fetal lung cSMARCA5 circRNA homo sapiens SMARCA5 26076956 Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development. Szabo L, Morey R, Palpant NJ, Wang PL, Afari N, Jiang C, Parast MM, Murry CE, Laurent LC, Salzman J. Genome Biol. 2015 induction during fetal development RNA-seq, qRT-PCR fetal heart, fetal lung cRANBP17 circRNA homo sapiens RANBP17 26076956 Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development. Szabo L, Morey R, Palpant NJ, Wang PL, Afari N, Jiang C, Parast MM, Murry CE, Laurent LC, Salzman J. Genome Biol. 2015 induction during fetal development RNA-seq, qRT-PCR fetal tissues (adrenal, heart, intestine, kidney, lung, stomach) cTTN1 circRNA homo sapiens TTN cardiomyopathy 27531932 RBM20 Regulates Circular RNA Production From the Titin Gene. Khan MA, Reckman YJ, Aufiero S, van den Hoogenhof MM, van der Made I, Beqqali A, Koolbergen DR, Rasmussen TB, van der Velden J, Creemers EE, Pinto YM. Circ Res. 2016 differentially expressed in disease, expreseed in human tissues RNA-seq, RT-PCR fresh left ventricular (LV) tissue from patients with end-stage idiopathic dilated cardiomyopathy (DCM), LV tissue of hypertrophic cardiomyopathy (HCM) patients, LV tissue of non-failing donors which had no history of cardiac abnormalities, adult muscle tissues (heart), fetal tissues (heart) cTTN2 circRNA homo sapiens TTN cardiomyopathy 27531932 RBM20 Regulates Circular RNA Production From the Titin Gene. Khan MA, Reckman YJ, Aufiero S, van den Hoogenhof MM, van der Made I, Beqqali A, Koolbergen DR, Rasmussen TB, van der Velden J, Creemers EE, Pinto YM. Circ Res. 2016 differentially expressed in disease, expreseed in human tissues RNA-seq, RT-PCR fresh left ventricular (LV) tissue from patients with end-stage idiopathic dilated cardiomyopathy (DCM), LV tissue of hypertrophic cardiomyopathy (HCM) patients, LV tissue of non-failing donors which had no history of cardiac abnormalities, adult muscle tissues (heart), fetal tissues (heart) cTTN3 circRNA homo sapiens TTN cardiomyopathy 27531932 RBM20 Regulates Circular RNA Production From the Titin Gene. Khan MA, Reckman YJ, Aufiero S, van den Hoogenhof MM, van der Made I, Beqqali A, Koolbergen DR, Rasmussen TB, van der Velden J, Creemers EE, Pinto YM. Circ Res. 2016 differentially expressed in disease, expreseed in human tissues RNA-seq, RT-PCR fresh left ventricular (LV) tissue from patients with end-stage idiopathic dilated cardiomyopathy (DCM), LV tissue of hypertrophic cardiomyopathy (HCM) patients, LV tissue of non-failing donors which had no history of cardiac abnormalities, adult muscle tissues (heart), fetal tissues (heart) cTTN4 circRNA homo sapiens TTN cardiomyopathy 27531932 RBM20 Regulates Circular RNA Production From the Titin Gene. Khan MA, Reckman YJ, Aufiero S, van den Hoogenhof MM, van der Made I, Beqqali A, Koolbergen DR, Rasmussen TB, van der Velden J, Creemers EE, Pinto YM. Circ Res. 2016 differentially expressed in disease, expreseed in human tissues RNA-seq, RT-PCR fresh left ventricular (LV) tissue from patients with end-stage idiopathic dilated cardiomyopathy (DCM), LV tissue of hypertrophic cardiomyopathy (HCM) patients, LV tissue of non-failing donors which had no history of cardiac abnormalities, adult muscle tissues (heart), fetal tissues (heart) cTTN5 circRNA homo sapiens TTN cardiomyopathy 27531932 RBM20 Regulates Circular RNA Production From the Titin Gene. Khan MA, Reckman YJ, Aufiero S, van den Hoogenhof MM, van der Made I, Beqqali A, Koolbergen DR, Rasmussen TB, van der Velden J, Creemers EE, Pinto YM. Circ Res. 2016 differentially expressed in disease, expreseed in human tissues RNA-seq, RT-PCR fresh left ventricular (LV) tissue from patients with end-stage idiopathic dilated cardiomyopathy (DCM), LV tissue of hypertrophic cardiomyopathy (HCM) patients, LV tissue of non-failing donors which had no history of cardiac abnormalities, adult muscle tissues (heart), fetal tissues (heart) cTNNI3K circRNA homo sapiens TNNI3K cardiomyopathy 27531932 RBM20 Regulates Circular RNA Production From the Titin Gene. Khan MA, Reckman YJ, Aufiero S, van den Hoogenhof MM, van der Made I, Beqqali A, Koolbergen DR, Rasmussen TB, van der Velden J, Creemers EE, Pinto YM. Circ Res. 2016 differentially expressed in disease, expreseed in human tissues RNA-seq, RT-PCR fresh left ventricular (LV) tissue from patients with end-stage idiopathic dilated cardiomyopathy (DCM), LV tissue of hypertrophic cardiomyopathy (HCM) patients, LV tissue of non-failing donors which had no history of cardiac abnormalities, adult muscle tissues (skeletal, heart), fetal tissues (heart, brain) cRYR2-1 circRNA homo sapiens RYR2 cardiomyopathy 27531932 RBM20 Regulates Circular RNA Production From the Titin Gene. Khan MA, Reckman YJ, Aufiero S, van den Hoogenhof MM, van der Made I, Beqqali A, Koolbergen DR, Rasmussen TB, van der Velden J, Creemers EE, Pinto YM. Circ Res. 2016 differentially expressed in disease, expreseed in human tissues RNA-seq, RT-PCR fresh left ventricular (LV) tissue from patients with end-stage idiopathic dilated cardiomyopathy (DCM), LV tissue of hypertrophic cardiomyopathy (HCM) patients, LV tissue of non-failing donors which had no history of cardiac abnormalities, adult non-muscle tissues (brain, thyroid, lung), adult muscle tissues (stomach, heart), fetal tissues (heart, brain) cSLC8A1 circRNA homo sapiens SLC8A1 cardiomyopathy 27531932 RBM20 Regulates Circular RNA Production From the Titin Gene. Khan MA, Reckman YJ, Aufiero S, van den Hoogenhof MM, van der Made I, Beqqali A, Koolbergen DR, Rasmussen TB, van der Velden J, Creemers EE, Pinto YM. Circ Res. 2016 differentially expressed in disease, expreseed in human tissues RNA-seq, RT-PCR fresh left ventricular (LV) tissue from patients with end-stage idiopathic dilated cardiomyopathy (DCM), LV tissue of hypertrophic cardiomyopathy (HCM) patients, LV tissue of non-failing donors which had no history of cardiac abnormalities, adult non-muscle tissues (brain,lung, kidney), adult muscle tissues (stomach, intestine, uterus, heart), fetal tissues (heart, brain) cCAMK2D circRNA homo sapiens CAMK2D cardiomyopathy 27531932 RBM20 Regulates Circular RNA Production From the Titin Gene. Khan MA, Reckman YJ, Aufiero S, van den Hoogenhof MM, van der Made I, Beqqali A, Koolbergen DR, Rasmussen TB, van der Velden J, Creemers EE, Pinto YM. Circ Res. 2016 differentially expressed in disease, expreseed in human tissues RNA-seq, RT-PCR fresh left ventricular (LV) tissue from patients with end-stage idiopathic dilated cardiomyopathy (DCM), LV tissue of hypertrophic cardiomyopathy (HCM) patients, LV tissue of non-failing donors which had no history of cardiac abnormalities, adult non-muscle tissues (thyroid, lung, kidney), adult muscle tissues (stomach, intestine, skeletal, heart), fetal tissues (heart) cLAMA2 circRNA homo sapiens LAMA2 cardiomyopathy 27531932 RBM20 Regulates Circular RNA Production From the Titin Gene. Khan MA, Reckman YJ, Aufiero S, van den Hoogenhof MM, van der Made I, Beqqali A, Koolbergen DR, Rasmussen TB, van der Velden J, Creemers EE, Pinto YM. Circ Res. 2016 differentially expressed in disease, expreseed in human tissues RNA-seq, RT-PCR fresh left ventricular (LV) tissue from patients with end-stage idiopathic dilated cardiomyopathy (DCM), LV tissue of hypertrophic cardiomyopathy (HCM) patients, LV tissue of non-failing donors which had no history of cardiac abnormalities,adult muscle tissues ( heart), fetal tissues (heart) hsa_circRNA_100269 circRNA homo sapiens gastric cancer 28206972 Circular RNAs signature predicts the early recurrence of stage III gastric cancer after radical surgery. Zhang Y, Li J, Yu J, Liu H, Shen Z, Ye G, Mou T, Qi X, Li G. Oncotarget. 2017 significantly different between the high and low expression groups in the training cohort microarray, qRT-PCR, FISH gastric cancer and adjacent tissues four-circRNA-based classifier could predict the early recurrence of stage III gastric cancer gastric cancer and adjacent tissues hsa_circRNA_101308 circRNA homo sapiens gastric cancer 28206972 Circular RNAs signature predicts the early recurrence of stage III gastric cancer after radical surgery. Zhang Y, Li J, Yu J, Liu H, Shen Z, Ye G, Mou T, Qi X, Li G. Oncotarget. 2017 significantly different between the high and low expression groups in the training cohort microarray, qRT-PCR, FISH gastric cancer and adjacent tissues four-circRNA-based classifier could predict the early recurrence of stage III gastric cancer gastric cancer and adjacent tissues hsa_circRNA_104916 circRNA homo sapiens gastric cancer 28206972 Circular RNAs signature predicts the early recurrence of stage III gastric cancer after radical surgery. Zhang Y, Li J, Yu J, Liu H, Shen Z, Ye G, Mou T, Qi X, Li G. Oncotarget. 2017 significantly different between the high and low expression groups in the training cohort microarray, qRT-PCR, FISH gastric cancer and adjacent tissues four-circRNA-based classifier could predict the early recurrence of stage III gastric cancer gastric cancer and adjacent tissues hsacircRNA_104423 circRNA homo sapiens gastric cancer 28206972 Circular RNAs signature predicts the early recurrence of stage III gastric cancer after radical surgery. Zhang Y, Li J, Yu J, Liu H, Shen Z, Ye G, Mou T, Qi X, Li G. Oncotarget. 2017 significantly different between the high and low expression groups in the training cohort microarray, qRT-PCR, FISH gastric cancer and adjacent tissues four-circRNA-based classifier could predict the early recurrence of stage III gastric cancer gastric cancer and adjacent tissues Circular RNA ciRS-7 circRNA homo sapiens CDR1 gastric cancer 28608528 Overexpression of Circular RNA ciRS-7 Abrogates the Tumor Suppressive Effect of miR-7 on Gastric Cancer via PTEN/PI3K/AKT Signaling Pathway. Pan H, Li T, Jiang Y, Pan C, Ding Y, Huang Z, Yu H, Kong D. J Cell Biochem. 2018 Expression of ciRS-7 was upregulated in GC tissues qRT-PCR GC patients and matched noncancerous control tissues, GES-1, MGC-803 and HGC-27 HIGH ciRS-7 EXPRESSION PREDICTS POOR SURVIVAL IN GC PATIENTS. ciRS-7 INHIBITED miR-7 MEDIATED TUMOR SUPPRESSION IN GC. gain of function MGC-803 and HGC-27 Female BALB/c nude mice that were 4¨C5 weeks old GC patients and matched noncancerous control tissues hsa_circRNA_001066 circRNA homo sapiens gastric cancer 28184940 Circular RNA and gene expression profiles in gastric cancer based on microarray chip technology. Sui W, Shi Z, Xue W, Ou M, Zhu Y, Chen J, Lin H, Liu F, Dai Y. Oncol Rep. 2017 down microarray, qRT-PCR, FISH GC tissues and adjacent tissue samples hsa_circRNA_001959 circRNA homo sapiens gastric cancer 28184940 Circular RNA and gene expression profiles in gastric cancer based on microarray chip technology. Sui W, Shi Z, Xue W, Ou M, Zhu Y, Chen J, Lin H, Liu F, Dai Y. Oncol Rep. 2017 down microarray, qRT-PCR, FISH GC tissues and adjacent tissue samples hsa_circRNA_400066 circRNA homo sapiens gastric cancer 28184940 Circular RNA and gene expression profiles in gastric cancer based on microarray chip technology. Sui W, Shi Z, Xue W, Ou M, Zhu Y, Chen J, Lin H, Liu F, Dai Y. Oncol Rep. 2017 down microarray, qRT-PCR, FISH GC tissues and adjacent tissue samples hsa_circRNA_000543 circRNA homo sapiens gastric cancer 28184940 Circular RNA and gene expression profiles in gastric cancer based on microarray chip technology. Sui W, Shi Z, Xue W, Ou M, Zhu Y, Chen J, Lin H, Liu F, Dai Y. Oncol Rep. 2017 up microarray, qRT-PCR, FISH GC tissues and adjacent tissue samples hsa_circRNA_000792 circRNA homo sapiens gastric cancer 28184940 Circular RNA and gene expression profiles in gastric cancer based on microarray chip technology. Sui W, Shi Z, Xue W, Ou M, Zhu Y, Chen J, Lin H, Liu F, Dai Y. Oncol Rep. 2017 up microarray, qRT-PCR, FISH GC tissues and adjacent tissue samples hsa_circRNA_400071 circRNA homo sapiens gastric cancer 28184940 Circular RNA and gene expression profiles in gastric cancer based on microarray chip technology. Sui W, Shi Z, Xue W, Ou M, Zhu Y, Chen J, Lin H, Liu F, Dai Y. Oncol Rep. 2017 up microarray, qRT-PCR, FISH GC tissues and adjacent tissue samples hsa_circRNA7690-15 circRNA homo sapiens GDA gastric cancer 28980874 Analysis of co-expression networks for circular RNAs and mRNAs reveals that circular RNAs hsa_circ_0047905, hsa_circ_0138960 and has-circRNA7690-15 are candidate oncogenes in gastric cancer. Lai Z, Yang Y, Yan Y, Li T, Li Y, Wang Z, Shen Z, Ye Y, Jiang K, Wang S. Cell Cycle. 2017 upregulated in GC tissues compared with noncancerous tissue microarray, qRT-PCR GC tissues and noncancerous tissue, AGS Depletion of circRNA7690-15 suppressed AGS cell proliferation and invasion in vitro. The AUC of circRNA7690-15 was 0.681 (95% CI: 0.546-0.815). loss of function AGS GC tissues circRNA.20159 circRNA homo sapiens gestational diabetes mellitus 29526755 Circular RNA expression profiles in placental villi from women with gestational diabetes mellitus. Yan L, Feng J, Cheng F, Cui X, Gao L, Chen Y, Wang F, Zhong T, Li Y, Liu L. Biochem Biophys Res Commun. 2018 Down-regulated in gestational diabetes mellitus (GDM) compared to normal controls. RNA-seq, qRT-PCR gestational diabetes mellitus (GDM), normal controls circRNA.37134 circRNA homo sapiens gestational diabetes mellitus 29526755 Circular RNA expression profiles in placental villi from women with gestational diabetes mellitus. Yan L, Feng J, Cheng F, Cui X, Gao L, Chen Y, Wang F, Zhong T, Li Y, Liu L. Biochem Biophys Res Commun. 2018 Down-regulated in gestational diabetes mellitus (GDM) compared to normal controls. RNA-seq, qRT-PCR gestational diabetes mellitus (GDM), normal controls circRNA.22054 circRNA homo sapiens gestational diabetes mellitus 29526755 Circular RNA expression profiles in placental villi from women with gestational diabetes mellitus. Yan L, Feng J, Cheng F, Cui X, Gao L, Chen Y, Wang F, Zhong T, Li Y, Liu L. Biochem Biophys Res Commun. 2018 Down-regulated in gestational diabetes mellitus (GDM) compared with normal controls. RNA-seq, qRT-PCR gestational diabetes mellitus (GDM), normal controls circRNA.1030 circRNA homo sapiens gestational diabetes mellitus 29526755 Circular RNA expression profiles in placental villi from women with gestational diabetes mellitus. Yan L, Feng J, Cheng F, Cui X, Gao L, Chen Y, Wang F, Zhong T, Li Y, Liu L. Biochem Biophys Res Commun. 2018 Up-regulated in gestational diabetes mellitus (GDM) compared to normal controls. RNA-seq, qRT-PCR gestational diabetes mellitus (GDM), normal controls circRNA.33299 circRNA homo sapiens gestational diabetes mellitus 29526755 Circular RNA expression profiles in placental villi from women with gestational diabetes mellitus. Yan L, Feng J, Cheng F, Cui X, Gao L, Chen Y, Wang F, Zhong T, Li Y, Liu L. Biochem Biophys Res Commun. 2018 Up-regulated in gestational diabetes mellitus (GDM) compared to normal controls. RNA-seq, qRT-PCR gestational diabetes mellitus (GDM), normal controls circRNA.5333 circRNA homo sapiens gestational diabetes mellitus 29526755 Circular RNA expression profiles in placental villi from women with gestational diabetes mellitus. Yan L, Feng J, Cheng F, Cui X, Gao L, Chen Y, Wang F, Zhong T, Li Y, Liu L. Biochem Biophys Res Commun. 2018 Up-regulated in gestational diabetes mellitus (GDM) compared to normal controls. RNA-seq, qRT-PCR gestational diabetes mellitus (GDM), normal controls circ-SHPRH circRNA homo sapiens SHPRH MKIQLRDPGAKALVFSTWQDVLDIISKALTDNNMEFAQISRVKTFQENLSAFKRDPQINILLLPLHTGSNGLTIIEATHVLLVEPILNPAHELQAIGRVHRIGQTKPTIVHRFLIKATIEERMQAMLKTAERRAAILQKWKLWSEL glioblastoma 29343848 A novel protein encoded by the circular form of the SHPRH gene suppresses glioma tumorigenesis. Zhang M, Huang N, Yang X, Luo J, Yan S, Xiao F, Chen W, Gao X, Zhao K, Zhou H, Li Z, Ming L, Xie B, Zhang N. Oncogene. 2018 We identified a lower-expressed circRNA in glioblastoma, circ-SHPRH, which translated a 146-aa novel protein using overlapping genetic codes. RNA-seq, qRT-PCR Glioma samples and normal brain tissues, U251, U373, 293T circ-SHPRH encodes a novel protein named SHPRH-146aa. SHPRH-146aa protects full-length SHPRH from degradation by the ubiquitin proteasome. Stabilized SHPRH sequentially ubiquitinates proliferating cell nuclear antigen (PCNA) as an E3 ligase, leading to inhibited cell proliferation and tumorigenicity. loss of function, gain of function U251, U373, 293T nude mice circRNA_103611 circRNA homo sapiens GPR125 female infertility 28644873 Circular RNA expression profiling of human granulosa cells during maternal aging reveals novel transcripts associated with assisted reproductive technology outcomes. Cheng J, Huang J, Yuan S, Zhou S, Yan W, Shen W, Chen Y, Xia X, Luo A, Zhu D, Wang S. PLoS One. 2017 Down-regulated in older women qRT-PCR, microarray granulosa cells circRNA_101889 circRNA homo sapiens USP10 female infertility 28644873 Circular RNA expression profiling of human granulosa cells during maternal aging reveals novel transcripts associated with assisted reproductive technology outcomes. Cheng J, Huang J, Yuan S, Zhou S, Yan W, Shen W, Chen Y, Xia X, Luo A, Zhu D, Wang S. PLoS One. 2017 Down-regulated in older women. Significantly down-regulated in 20 advanced age women compared with 20 young age women. circRNA_101889 expression in GCs varied significantly according to the type of gonadotropin treatment (recombinant follicle-stimulating hormone (r-FSH) and/or highly purified human menopausal gonadotropin (HP-hMG) (P = 0.024). qRT-PCR, microarray granulosa cells circRNA_100833 circRNA homo sapiens FADS2 female infertility 28644873 Circular RNA expression profiling of human granulosa cells during maternal aging reveals novel transcripts associated with assisted reproductive technology outcomes. Cheng J, Huang J, Yuan S, Zhou S, Yan W, Shen W, Chen Y, Xia X, Luo A, Zhu D, Wang S. PLoS One. 2017 Up-regulated in older women. qRT-PCR, microarray granulosa cells circRNA_103828 circRNA homo sapiens HMGCS1 female infertility 28644873 Circular RNA expression profiling of human granulosa cells during maternal aging reveals novel transcripts associated with assisted reproductive technology outcomes. Cheng J, Huang J, Yuan S, Zhou S, Yan W, Shen W, Chen Y, Xia X, Luo A, Zhu D, Wang S. PLoS One. 2017 Up-regulated in older women. qRT-PCR, microarray granulosa cells circRNA_104852 circRNA homo sapiens RAD23B female infertility 28644873 Circular RNA expression profiling of human granulosa cells during maternal aging reveals novel transcripts associated with assisted reproductive technology outcomes. Cheng J, Huang J, Yuan S, Zhou S, Yan W, Shen W, Chen Y, Xia X, Luo A, Zhu D, Wang S. PLoS One. 2017 Up-regulated in older women. qRT-PCR, microarray granulosa cells circRNA_103827 circRNA homo sapiens HMGCS1 female infertility 28644873 Circular RNA expression profiling of human granulosa cells during maternal aging reveals novel transcripts associated with assisted reproductive technology outcomes. Cheng J, Huang J, Yuan S, Zhou S, Yan W, Shen W, Chen Y, Xia X, Luo A, Zhu D, Wang S. PLoS One. 2017 Up-regulated in older women. Significantly up-regulated in 20 advanced age women compared with 20 young age women. circRNA_103827 levels were significantly and positively associated with maternal age in partial correlation analysis (partial r = 0.332, P = 0.045). circRNA_103827 expressions in GCs were negatively correlated with the number of top quality embryos (r = -0.235, P = 0.036). qRT-PCR, microarray granulosa cells circRNA_103829 circRNA homo sapiens HMGCS1 female infertility 28644873 Circular RNA expression profiling of human granulosa cells during maternal aging reveals novel transcripts associated with assisted reproductive technology outcomes. Cheng J, Huang J, Yuan S, Zhou S, Yan W, Shen W, Chen Y, Xia X, Luo A, Zhu D, Wang S. PLoS One. 2017 Up-regulated in older women. Significantly up-regulated in 20 advanced age women compared with 20 young age women. circRNA_103829 was significantly up-regulated in GCs from women who received high doses of gonadotropins (>=2500 IU/l) compared to those treated with doses <2500 IU/l (P = 0.022). qRT-PCR, microarray granulosa cells circRNA_104816 circRNA homo sapiens IARS female infertility 28644873 Circular RNA expression profiling of human granulosa cells during maternal aging reveals novel transcripts associated with assisted reproductive technology outcomes. Cheng J, Huang J, Yuan S, Zhou S, Yan W, Shen W, Chen Y, Xia X, Luo A, Zhu D, Wang S. PLoS One. 2017 Up-regulated in older women. Significantly up-regulated in 20 advanced age women compared with 20 young age women. circRNA_104816 levels were significantly and positively associated with maternal age in partial correlation analysis (partial r = 0.473, P = 0.003). circRNA_104816 expressions in GCs were negatively correlated with the number of top quality embryos (r = -0.221, P = 0.049). qRT-PCR, microarray granulosa cells circ MAN1A2 Ex5-2 circRNA homo sapiens MAN1A2 25053845 Is an observed non-co-linear RNA product spliced in trans, in cis or just in vitro Yu CY, Liu HJ, Hung LY, Kuo HC, Chuang TJ. Nucleic Acids Res. 2014 detected in H1, NTU1 RT-PCR H1, NTU1 f-circEA1 fusion circRNA homo sapiens EML4-ALK1 fusion gene GGCGAGCTACTATAGAAAGGGAGGCTGTGCCATGCTGCCAGTTAAGTGGATGCCCCCAGAGGCCTTCATGGAAGGAATATTCACTTCTAAAACAGACACATGACAACAAATGAAGTTGTTTTGGCTGTGGAGTTTCACCCAACAGATGCAAATACCATAATTACATGCGGTAAATCTCATATTTTCTTCTGGACCTGGAGCGGCAATTCACTAACAAGAAAACAGGCAATTTTTGGGAAATATGAAAAGCCAAAATTTGTGCAGTGTTTAGCATTCTTGGGGAATGGAGATGTTCTTACTGGAGACTCAGGTGGAGTCATGCTTA lung cancer 27040497 Oncogenic Role of Fusion-circRNAs Derived from Cancer-Associated Chromosomal Translocations. Guarnerio J, Bezzi M, Jeong JC, Paffenholz SV, Berry K, Naldini MM, Lo-Coco F, Tay Y, Beck AH, Pandolfi PP. Cell. 2016 f-circEA1 is expressed in H3321 lung cancer cell lines. PCR products sequencing H3321 lung cancer cell line - H3321 lung cancer cell line Cdr1as circRNA homo sapiens CDR1 25053845 Is an observed non-co-linear RNA product spliced in trans, in cis or just in vitro Yu CY, Liu HJ, Hung LY, Kuo HC, Chuang TJ. Nucleic Acids Res. 2014 detected in H9, H1, NTU1 RT-PCR H9, H1, NTU1 circ-ITCH circRNA homo sapiens ITCH hepatocellular carcinoma 28636993 Polymorphisms and expression pattern of circular RNA circ-ITCH contributes to the carcinogenesis of hepatocellular carcinoma. Guo W, Zhang J, Zhang D, Cao S, Li G, Zhang S, Wang Z, Wen P, Yang H, Shi X, Pan J, Ye H. Oncotarget. 2017 the expression level of circ-ITCH was significantly lower in HCC qRT-PCR HCC and the adjacent tissues high expression of circ-ITCH was associated with favorable survival of HCC (HR=0.45; 95% CI=0.29-0.68; P value < 0.001) HCC and the adjacent tissues hsacircRNA1 circRNA homo sapiens 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency. Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, Loewer A, Ziebold U, Landthaler M, Kocks C, le Noble F, Rajewsky N. Nature. 2013 The circRNA was validated experimentally. qRT-PCR, sanger sequencing HEK293 cells hsacircRNA11 circRNA homo sapiens 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency. Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, Loewer A, Ziebold U, Landthaler M, Kocks C, le Noble F, Rajewsky N. Nature. 2013 The circRNA was validated experimentally. qRT-PCR, sanger sequencing HEK293 cells hsacircRNA12 circRNA homo sapiens 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency. Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, Loewer A, Ziebold U, Landthaler M, Kocks C, le Noble F, Rajewsky N. Nature. 2013 The circRNA was validated experimentally. qRT-PCR, sanger sequencing HEK293 cells hsacircRNA13 circRNA homo sapiens 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency. Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, Loewer A, Ziebold U, Landthaler M, Kocks C, le Noble F, Rajewsky N. Nature. 2013 The circRNA was validated experimentally. qRT-PCR, sanger sequencing HEK293 cells hsacircRNA15 circRNA homo sapiens 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency. Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, Loewer A, Ziebold U, Landthaler M, Kocks C, le Noble F, Rajewsky N. Nature. 2013 The circRNA was validated experimentally. qRT-PCR, sanger sequencing HEK293 cells hsacircRNA16 circRNA homo sapiens 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency. Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, Loewer A, Ziebold U, Landthaler M, Kocks C, le Noble F, Rajewsky N. Nature. 2013 The circRNA was validated experimentally. qRT-PCR, sanger sequencing HEK293 cells hsacircRNA17 circRNA homo sapiens 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency. Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, Loewer A, Ziebold U, Landthaler M, Kocks C, le Noble F, Rajewsky N. Nature. 2013 The circRNA was validated experimentally. qRT-PCR, sanger sequencing HEK293 cells hsacircRNA18 circRNA homo sapiens 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency. Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, Loewer A, Ziebold U, Landthaler M, Kocks C, le Noble F, Rajewsky N. Nature. 2013 The circRNA was validated experimentally. qRT-PCR, sanger sequencing HEK293 cells hsacircRNA19 circRNA homo sapiens 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency. Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, Loewer A, Ziebold U, Landthaler M, Kocks C, le Noble F, Rajewsky N. Nature. 2013 The circRNA was validated experimentally. qRT-PCR, sanger sequencing HEK293 cells hsacircRNA2 circRNA homo sapiens 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency. Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, Loewer A, Ziebold U, Landthaler M, Kocks C, le Noble F, Rajewsky N. Nature. 2013 The circRNA was validated experimentally. qRT-PCR, sanger sequencing HEK293 cells hsacircRNA20 circRNA homo sapiens 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency. Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, Loewer A, Ziebold U, Landthaler M, Kocks C, le Noble F, Rajewsky N. Nature. 2013 The circRNA was validated experimentally. qRT-PCR, sanger sequencing HEK293 cells hsacircRNA21 circRNA homo sapiens 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency. Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, Loewer A, Ziebold U, Landthaler M, Kocks C, le Noble F, Rajewsky N. Nature. 2013 The circRNA was validated experimentally. qRT-PCR, sanger sequencing HEK293 cells hsacircRNA22 circRNA homo sapiens 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency. Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, Loewer A, Ziebold U, Landthaler M, Kocks C, le Noble F, Rajewsky N. Nature. 2013 The circRNA was validated experimentally. qRT-PCR, sanger sequencing HEK293 cells hsacircRNA25 circRNA homo sapiens 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency. Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, Loewer A, Ziebold U, Landthaler M, Kocks C, le Noble F, Rajewsky N. Nature. 2013 The circRNA was validated experimentally. qRT-PCR, sanger sequencing HEK293 cells hsacircRNA26 circRNA homo sapiens 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency. Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, Loewer A, Ziebold U, Landthaler M, Kocks C, le Noble F, Rajewsky N. Nature. 2013 The circRNA was validated experimentally. qRT-PCR, sanger sequencing HEK293 cells hsacircRNA3 circRNA homo sapiens 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency. Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, Loewer A, Ziebold U, Landthaler M, Kocks C, le Noble F, Rajewsky N. Nature. 2013 The circRNA was validated experimentally. qRT-PCR, sanger sequencing HEK293 cells hsacircRNA4 circRNA homo sapiens 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency. Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, Loewer A, Ziebold U, Landthaler M, Kocks C, le Noble F, Rajewsky N. Nature. 2013 The circRNA was validated experimentally. qRT-PCR, sanger sequencing HEK293 cells hsacircRNA5 circRNA homo sapiens 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency. Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, Loewer A, Ziebold U, Landthaler M, Kocks C, le Noble F, Rajewsky N. Nature. 2013 The circRNA was validated experimentally. qRT-PCR, sanger sequencing HEK293 cells hsacircRNA6 circRNA homo sapiens 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency. Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, Loewer A, Ziebold U, Landthaler M, Kocks C, le Noble F, Rajewsky N. Nature. 2013 The circRNA was validated experimentally. qRT-PCR, sanger sequencing HEK293 cells hsacircRNA7 circRNA homo sapiens 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency. Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, Loewer A, Ziebold U, Landthaler M, Kocks C, le Noble F, Rajewsky N. Nature. 2013 The circRNA was validated experimentally. qRT-PCR, sanger sequencing HEK293 cells hsacircRNA9 circRNA homo sapiens 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency. Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, Loewer A, Ziebold U, Landthaler M, Kocks C, le Noble F, Rajewsky N. Nature. 2013 The circRNA was validated experimentally. qRT-PCR, sanger sequencing HEK293 cells circAFF1 circRNA homo sapiens AFF1 25768908 The RNA binding protein quaking regulates formation of circRNAs. Conn SJ, Pillman KA, Toubia J, Conn VM, Salmanidis M, Phillips CA, Roslan S, Schreiber AW, Gregory PA, Goodall GJ. Cell. 2015 circRNA with adjacent QKI PAR-CLIP site RNA-seq, qRT-PCR HEK293T circAFTPH circRNA homo sapiens AFTPH 25768908 The RNA binding protein quaking regulates formation of circRNAs. Conn SJ, Pillman KA, Toubia J, Conn VM, Salmanidis M, Phillips CA, Roslan S, Schreiber AW, Gregory PA, Goodall GJ. Cell. 2015 circRNA with adjacent QKI PAR-CLIP site RNA-seq, qRT-PCR HEK293T circCAMSAP1 circRNA homo sapiens CAMSAP1 25768908 The RNA binding protein quaking regulates formation of circRNAs. Conn SJ, Pillman KA, Toubia J, Conn VM, Salmanidis M, Phillips CA, Roslan S, Schreiber AW, Gregory PA, Goodall GJ. Cell. 2015 circRNA with adjacent QKI PAR-CLIP site RNA-seq, qRT-PCR HEK293T circGON4L circRNA homo sapiens GON4L 25768908 The RNA binding protein quaking regulates formation of circRNAs. Conn SJ, Pillman KA, Toubia J, Conn VM, Salmanidis M, Phillips CA, Roslan S, Schreiber AW, Gregory PA, Goodall GJ. Cell. 2015 circRNA with adjacent QKI PAR-CLIP site RNA-seq, qRT-PCR HEK293T circMGA circRNA homo sapiens MGA 25768908 The RNA binding protein quaking regulates formation of circRNAs. Conn SJ, Pillman KA, Toubia J, Conn VM, Salmanidis M, Phillips CA, Roslan S, Schreiber AW, Gregory PA, Goodall GJ. Cell. 2015 circRNA with adjacent QKI PAR-CLIP site RNA-seq, qRT-PCR HEK293T circPCMTD1 circRNA homo sapiens PCMTD1 25768908 The RNA binding protein quaking regulates formation of circRNAs. Conn SJ, Pillman KA, Toubia J, Conn VM, Salmanidis M, Phillips CA, Roslan S, Schreiber AW, Gregory PA, Goodall GJ. Cell. 2015 circRNA with adjacent QKI PAR-CLIP site RNA-seq, qRT-PCR HEK293T circPVT1 circRNA homo sapiens PVT1 25768908 The RNA binding protein quaking regulates formation of circRNAs. Conn SJ, Pillman KA, Toubia J, Conn VM, Salmanidis M, Phillips CA, Roslan S, Schreiber AW, Gregory PA, Goodall GJ. Cell. 2015 circRNA with adjacent QKI PAR-CLIP site RNA-seq, qRT-PCR HEK293T circYTHDF2 circRNA homo sapiens YTHDF2 25768908 The RNA binding protein quaking regulates formation of circRNAs. Conn SJ, Pillman KA, Toubia J, Conn VM, Salmanidis M, Phillips CA, Roslan S, Schreiber AW, Gregory PA, Goodall GJ. Cell. 2015 circRNA with adjacent QKI PAR-CLIP site RNA-seq, qRT-PCR HEK293T circZNF608 circRNA homo sapiens ZNF608 25768908 The RNA binding protein quaking regulates formation of circRNAs. Conn SJ, Pillman KA, Toubia J, Conn VM, Salmanidis M, Phillips CA, Roslan S, Schreiber AW, Gregory PA, Goodall GJ. Cell. 2015 circRNA with adjacent QKI PAR-CLIP site RNA-seq, qRT-PCR HEK293T circCAMSAP1 circRNA homo sapiens CAMSAP1 22319583 Circular RNAs are the predominant transcript isoform from hundreds of human genes in diverse cell types. Salzman J, Gawad C, Wang PL, Lacayo N, Brown PO. PLoS One. 2012 As predicted from the circular RNA model, each of these transcripts was resistant to RNaseR degradation, suggesting that most scrambled transcripts are circular RNAs qRT-PCR HeLa circFBXW4 circRNA homo sapiens FBXW4 22319583 Circular RNAs are the predominant transcript isoform from hundreds of human genes in diverse cell types. Salzman J, Gawad C, Wang PL, Lacayo N, Brown PO. PLoS One. 2012 As predicted from the circular RNA model, each of these transcripts was resistant to RNaseR degradation, suggesting that most scrambled transcripts are circular RNAs qRT-PCR HeLa circMAN1A2 circRNA homo sapiens MAN1A2 22319583 Circular RNAs are the predominant transcript isoform from hundreds of human genes in diverse cell types. Salzman J, Gawad C, Wang PL, Lacayo N, Brown PO. PLoS One. 2012 As predicted from the circular RNA model, each of these transcripts was resistant to RNaseR degradation, suggesting that most scrambled transcripts are circular RNAs qRT-PCR HeLa circREXO4 circRNA homo sapiens REXO4 22319583 Circular RNAs are the predominant transcript isoform from hundreds of human genes in diverse cell types. Salzman J, Gawad C, Wang PL, Lacayo N, Brown PO. PLoS One. 2012 As predicted from the circular RNA model, each of these transcripts was resistant to RNaseR degradation, suggesting that most scrambled transcripts are circular RNAs qRT-PCR HeLa circRNF220 circRNA homo sapiens RNF220 22319583 Circular RNAs are the predominant transcript isoform from hundreds of human genes in diverse cell types. Salzman J, Gawad C, Wang PL, Lacayo N, Brown PO. PLoS One. 2012 As predicted from the circular RNA model, each of these transcripts was resistant to RNaseR degradation, suggesting that most scrambled transcripts are circular RNAs qRT-PCR HeLa circZKSCAN1 circRNA homo sapiens ZKSCAN1 22319583 Circular RNAs are the predominant transcript isoform from hundreds of human genes in diverse cell types. Salzman J, Gawad C, Wang PL, Lacayo N, Brown PO. PLoS One. 2012 As predicted from the circular RNA model, each of these transcripts was resistant to RNaseR degradation, suggesting that most scrambled transcripts are circular RNAs qRT-PCR HeLa circABTB1 circRNA homo sapiens ABTB1 24039610 Cell-type specific features of circular RNA expression. Salzman J, Chen RE, Olsen MN, Wang PL, Brown PO. PLoS Genet. 2013 HeLa RNA was treated with RNase R or a mock treatment, and then subjected to qPCR with isoform-specific primers. The fraction of linear and circular isoforms was normalized to the value measured in the mock treatment. All tested circular isoforms resisted RNase R. qRT-PCR HeLa circRNA-001622 circRNA homo sapiens cervical cancer 29511454 Extensive profiling of circular RNAs and the potential regulatory role of circRNA-000284 in cell proliferation and invasion of cervical cancer via sponging miR-506. Ma HB, Yao YN, Yu JJ, Chen XX, Li HF. Am J Transl Res. 2018 downregulated in cervical cancer cells microarray, qRT-PCR HeLa, CaSki, SiHa, C-33A, SW756, human normal cervical epithelial cells circRNA-104892 circRNA homo sapiens cervical cancer 29511454 Extensive profiling of circular RNAs and the potential regulatory role of circRNA-000284 in cell proliferation and invasion of cervical cancer via sponging miR-506. Ma HB, Yao YN, Yu JJ, Chen XX, Li HF. Am J Transl Res. 2018 downregulated in cervical cancer cells microarray, qRT-PCR HeLa, CaSki, SiHa, C-33A, SW756, human normal cervical epithelial cells circRNA-102049 circRNA homo sapiens cervical cancer 29511454 Extensive profiling of circular RNAs and the potential regulatory role of circRNA-000284 in cell proliferation and invasion of cervical cancer via sponging miR-506. Ma HB, Yao YN, Yu JJ, Chen XX, Li HF. Am J Transl Res. 2018 upregulated in cervical cancer cells microarray, qRT-PCR HeLa, CaSki, SiHa, C-33A, SW756, human normal cervical epithelial cells circZKSCAN1 circRNA homo sapiens ZKSCAN1 hepatocellular carcinoma 28211215 ZKSCAN1 gene and its related circular RNA (circZKSCAN1) both inhibit hepatocellular carcinoma cell growth, migration, and invasion but through different signaling pathways. Yao Z, Luo J, Hu K, Lin J, Huang H, Wang Q, Zhang P, Xiong Z, He C, Huang Z, Liu B, Yang Y. Mol Oncol. 2017 significantly lower (P<0.05) in the HCC RT-PCR and sequencing, qRT-PCR, FISH hepatocellular carcinoma tissue specimens and paired adjacent nontumorous tissues, L02, Huh7, SMMC-7721, BEL-7402, HepG2, and Hep3B Silencing circZKSCAN1 promoted cell proliferation, migration, and invasion. loss of function, gain of function HepG2, SMMC-7721 6-week-old male nude mice hepatocellular carcinoma tissue specimens and paired adjacent nontumorous tissues circ_ANKRD17 circRNA homo sapiens ANKRD17 27510448 CircRNA-protein complexes: IMP3 protein component defines subfamily of circRNPs. Schneider T, Hung LH, Schreiner S, Starke S, Eckhof H, Rossbach O, Reich S, Medenbach J, Bindereif A. Sci Rep. 2016 IMP3-associated circRNAs RT-PCR HepG2 circ_ARID1A circRNA homo sapiens ARID1A 27510448 CircRNA-protein complexes: IMP3 protein component defines subfamily of circRNPs. Schneider T, Hung LH, Schreiner S, Starke S, Eckhof H, Rossbach O, Reich S, Medenbach J, Bindereif A. Sci Rep. 2016 IMP3-associated circRNAs RT-PCR HepG2 circ_CDYL circRNA homo sapiens CDYL 27510448 CircRNA-protein complexes: IMP3 protein component defines subfamily of circRNPs. Schneider T, Hung LH, Schreiner S, Starke S, Eckhof H, Rossbach O, Reich S, Medenbach J, Bindereif A. Sci Rep. 2016 IMP3-associated circRNAs RT-PCR HepG2 circ_ELK4 circRNA homo sapiens ELK4 27510448 CircRNA-protein complexes: IMP3 protein component defines subfamily of circRNPs. Schneider T, Hung LH, Schreiner S, Starke S, Eckhof H, Rossbach O, Reich S, Medenbach J, Bindereif A. Sci Rep. 2016 IMP3-associated circRNAs RT-PCR HepG2 circ_FNDC3B circRNA homo sapiens FNDC3B 27510448 CircRNA-protein complexes: IMP3 protein component defines subfamily of circRNPs. Schneider T, Hung LH, Schreiner S, Starke S, Eckhof H, Rossbach O, Reich S, Medenbach J, Bindereif A. Sci Rep. 2016 IMP3-associated circRNAs RT-PCR HepG2 circ_NEIL3 circRNA homo sapiens NEIL3 27510448 CircRNA-protein complexes: IMP3 protein component defines subfamily of circRNPs. Schneider T, Hung LH, Schreiner S, Starke S, Eckhof H, Rossbach O, Reich S, Medenbach J, Bindereif A. Sci Rep. 2016 IMP3-associated circRNAs RT-PCR HepG2 circ_NFATC3 circRNA homo sapiens NFATC3 27510448 CircRNA-protein complexes: IMP3 protein component defines subfamily of circRNPs. Schneider T, Hung LH, Schreiner S, Starke S, Eckhof H, Rossbach O, Reich S, Medenbach J, Bindereif A. Sci Rep. 2016 IMP3-associated circRNAs RT-PCR HepG2 circ_PHC3 circRNA homo sapiens PHC3 27510448 CircRNA-protein complexes: IMP3 protein component defines subfamily of circRNPs. Schneider T, Hung LH, Schreiner S, Starke S, Eckhof H, Rossbach O, Reich S, Medenbach J, Bindereif A. Sci Rep. 2016 IMP3-associated circRNAs RT-PCR HepG2 hsa_circRNA_000367 circRNA homo sapiens Hepatic Steatosis 28717649 Circular RNA Profiling and Bioinformatic Modeling Identify Its Regulatory Role in Hepatic Steatosis. Guo XY, He CX, Wang YQ, Sun C, Li GM, Su Q, Pan Q, Fan JG. Biomed Res Int. 2017 Down-regulated in HepG2 cells of the model group demonstrated plentiful lipid droplets positive to Oil Red-O staining after the high-fat stimulation for 24 hours. qRT-PCR HepG2 hsa_circRNA_002082 circRNA homo sapiens Hepatic Steatosis 28717649 Circular RNA Profiling and Bioinformatic Modeling Identify Its Regulatory Role in Hepatic Steatosis. Guo XY, He CX, Wang YQ, Sun C, Li GM, Su Q, Pan Q, Fan JG. Biomed Res Int. 2017 Down-regulated in HepG2 cells of the model group demonstrated plentiful lipid droplets positive to Oil Red-O staining after the high-fat stimulation for 24 hours. qRT-PCR HepG2 hsa_circRNA_004183 circRNA homo sapiens Hepatic Steatosis 28717649 Circular RNA Profiling and Bioinformatic Modeling Identify Its Regulatory Role in Hepatic Steatosis. Guo XY, He CX, Wang YQ, Sun C, Li GM, Su Q, Pan Q, Fan JG. Biomed Res Int. 2017 Down-regulated in HepG2 cells of the model group demonstrated plentiful lipid droplets positive to Oil Red-O staining after the high-fat stimulation for 24 hours. qRT-PCR HepG2 hsa_circRNA_004121 circRNA homo sapiens Hepatic Steatosis 28717649 Circular RNA Profiling and Bioinformatic Modeling Identify Its Regulatory Role in Hepatic Steatosis. Guo XY, He CX, Wang YQ, Sun C, Li GM, Su Q, Pan Q, Fan JG. Biomed Res Int. 2017 Up-regulated in HepG2 cells of the model group demonstrated plentiful lipid droplets positive to Oil Red-O staining after the high-fat stimulation for 24 hours. qRT-PCR HepG2 hsa_circRNA_007850 circRNA homo sapiens Hepatic Steatosis 28717649 Circular RNA Profiling and Bioinformatic Modeling Identify Its Regulatory Role in Hepatic Steatosis. Guo XY, He CX, Wang YQ, Sun C, Li GM, Su Q, Pan Q, Fan JG. Biomed Res Int. 2017 Up-regulated in HepG2 cells of the model group demonstrated plentiful lipid droplets positive to Oil Red-O staining after the high-fat stimulation for 24 hours. qRT-PCR HepG2 hsa_circRNA_014724 circRNA homo sapiens Hepatic Steatosis 28717649 Circular RNA Profiling and Bioinformatic Modeling Identify Its Regulatory Role in Hepatic Steatosis. Guo XY, He CX, Wang YQ, Sun C, Li GM, Su Q, Pan Q, Fan JG. Biomed Res Int. 2017 Up-regulated in HepG2 cells of the model group demonstrated plentiful lipid droplets positive to Oil Red-O staining after the high-fat stimulation for 24 hours. qRT-PCR HepG2 circANKRD12 circRNA homo sapiens ANKRD12 27315811 Tracing the expression of circular RNAs in human pre-implantation embryos. Dang Y, Yan L, Hu B, Fan X, Ren Y, Li R, Lian Y, Yan J, Li Q, Zhang Y, Li M, Ren X, Huang J, Wu Y, Liu P, Wen L, Zhang C, Huang Y, Tang F, Qiao J. Genome Biol. 2016 detected in hESCs RNA-seq, RT-PCR, sanger sequencing, qRT-PCR hESCs circBRWD1 circRNA homo sapiens BRWD1 27315811 Tracing the expression of circular RNAs in human pre-implantation embryos. Dang Y, Yan L, Hu B, Fan X, Ren Y, Li R, Lian Y, Yan J, Li Q, Zhang Y, Li M, Ren X, Huang J, Wu Y, Liu P, Wen L, Zhang C, Huang Y, Tang F, Qiao J. Genome Biol. 2016 detected in hESCs RNA-seq, RT-PCR, sanger sequencing, qRT-PCR hESCs circFAT3 circRNA homo sapiens FAT3 27315811 Tracing the expression of circular RNAs in human pre-implantation embryos. Dang Y, Yan L, Hu B, Fan X, Ren Y, Li R, Lian Y, Yan J, Li Q, Zhang Y, Li M, Ren X, Huang J, Wu Y, Liu P, Wen L, Zhang C, Huang Y, Tang F, Qiao J. Genome Biol. 2016 detected in hESCs RNA-seq, RT-PCR, sanger sequencing, qRT-PCR hESCs circSPECC1 circRNA homo sapiens SPECC1 27315811 Tracing the expression of circular RNAs in human pre-implantation embryos. Dang Y, Yan L, Hu B, Fan X, Ren Y, Li R, Lian Y, Yan J, Li Q, Zhang Y, Li M, Ren X, Huang J, Wu Y, Liu P, Wen L, Zhang C, Huang Y, Tang F, Qiao J. Genome Biol. 2016 detected in hESCs RNA-seq, RT-PCR, sanger sequencing, qRT-PCR hESCs circTET1 circRNA homo sapiens TET1 27315811 Tracing the expression of circular RNAs in human pre-implantation embryos. Dang Y, Yan L, Hu B, Fan X, Ren Y, Li R, Lian Y, Yan J, Li Q, Zhang Y, Li M, Ren X, Huang J, Wu Y, Liu P, Wen L, Zhang C, Huang Y, Tang F, Qiao J. Genome Biol. 2016 detected in hESCs RNA-seq, RT-PCR, sanger sequencing, qRT-PCR hESCs circDOCK1 circRNA homo sapiens DOCK1 25768908 The RNA binding protein quaking regulates formation of circRNAs. Conn SJ, Pillman KA, Toubia J, Conn VM, Salmanidis M, Phillips CA, Roslan S, Schreiber AW, Gregory PA, Goodall GJ. Cell. 2015 downregulated in mesHMLE RNA-seq, qRT-PCR HMLE, mesHMLE circGNB1 circRNA homo sapiens GNB1 25768908 The RNA binding protein quaking regulates formation of circRNAs. Conn SJ, Pillman KA, Toubia J, Conn VM, Salmanidis M, Phillips CA, Roslan S, Schreiber AW, Gregory PA, Goodall GJ. Cell. 2015 downregulated in mesHMLE RNA-seq, qRT-PCR HMLE, mesHMLE circATXN2 circRNA homo sapiens ATXN2 25768908 The RNA binding protein quaking regulates formation of circRNAs. Conn SJ, Pillman KA, Toubia J, Conn VM, Salmanidis M, Phillips CA, Roslan S, Schreiber AW, Gregory PA, Goodall GJ. Cell. 2015 upregulated in mesHMLE RNA-seq, qRT-PCR HMLE, mesHMLE circRNA regulation by QKI circPOLE2 circRNA homo sapiens POLE2 25768908 The RNA binding protein quaking regulates formation of circRNAs. Conn SJ, Pillman KA, Toubia J, Conn VM, Salmanidis M, Phillips CA, Roslan S, Schreiber AW, Gregory PA, Goodall GJ. Cell. 2015 upregulated in mesHMLE RNA-seq, qRT-PCR HMLE, mesHMLE circRNA regulation by QKI circPOLE2 circRNA homo sapiens POLE2 25768908 The RNA binding protein quaking regulates formation of circRNAs. Conn SJ, Pillman KA, Toubia J, Conn VM, Salmanidis M, Phillips CA, Roslan S, Schreiber AW, Gregory PA, Goodall GJ. Cell. 2015 upregulated in mesHMLE RNA-seq, qRT-PCR HMLE, mesHMLE circPTPN4 circRNA homo sapiens PTPN4 25768908 The RNA binding protein quaking regulates formation of circRNAs. Conn SJ, Pillman KA, Toubia J, Conn VM, Salmanidis M, Phillips CA, Roslan S, Schreiber AW, Gregory PA, Goodall GJ. Cell. 2015 upregulated in mesHMLE RNA-seq, qRT-PCR HMLE, mesHMLE circRNA regulation by QKI circSHPRH circRNA homo sapiens SHPRH 25768908 The RNA binding protein quaking regulates formation of circRNAs. Conn SJ, Pillman KA, Toubia J, Conn VM, Salmanidis M, Phillips CA, Roslan S, Schreiber AW, Gregory PA, Goodall GJ. Cell. 2015 upregulated in mesHMLE RNA-seq, qRT-PCR HMLE, mesHMLE circRNA regulation by QKI circSMAD2 circRNA homo sapiens SMAD2 25768908 The RNA binding protein quaking regulates formation of circRNAs. Conn SJ, Pillman KA, Toubia J, Conn VM, Salmanidis M, Phillips CA, Roslan S, Schreiber AW, Gregory PA, Goodall GJ. Cell. 2015 upregulated in mesHMLE RNA-seq, qRT-PCR HMLE, mesHMLE circRNA regulation by QKI circSMARCA5 circRNA homo sapiens SMARCA5 25768908 The RNA binding protein quaking regulates formation of circRNAs. Conn SJ, Pillman KA, Toubia J, Conn VM, Salmanidis M, Phillips CA, Roslan S, Schreiber AW, Gregory PA, Goodall GJ. Cell. 2015 upregulated in mesHMLE RNA-seq, qRT-PCR HMLE, mesHMLE circRNA regulation by QKI Circular RNA of the human sphingomyelin synthase 1 gene circRNA homo sapiens SMS1 26274505 Circular RNA of the human sphingomyelin synthase 1 gene: Multiple splice variants, evolutionary conservatism and expression in different tissues. Filippenkov IB, Sudarkina OY, Limborska SA, Dergunova LV. RNA Biol. 2015 predominantly found in different parts of the brain northern blots, RT-PCR human (corpus callosum, thalamus, hippocampus, hypothalamus, lobus parletalls, sub. nigra, frontal cortex, med. oblongata, cerebellum, lymph node, spleen, blood, lung, testes, medulla renis, liver, cortex renis, placenta), rat (subcortex, frontal cortex, cerebellum, lung, kidney, spleen, liver), mouse (brain, lung, kidney, spleen) circRNA4 circRNA homo sapiens 26485708 Identification and Characterization of Circular RNAs As a New Class of Putative Biomarkers in Human Blood. Memczak S, Papavasileiou P, Peters O, Rajewsky N. PLoS One. 2015 For the remaining seven circRNA candidates, we tested circularity using previously established assays: 1) resistance to the 3-5 exonuclease RNase R and 2) Sanger sequencing of PCR amplicons to confirm the sequence of predicted head-to-tail splice junctions. With these assays we validated 7/7 tested candidates suggesting that the overall false positive rate in our data sets is low. qRT-PCR human blood circRNA5 circRNA homo sapiens 26485708 Identification and Characterization of Circular RNAs As a New Class of Putative Biomarkers in Human Blood. Memczak S, Papavasileiou P, Peters O, Rajewsky N. PLoS One. 2015 For the remaining seven circRNA candidates, we tested circularity using previously established assays: 1) resistance to the 3¡¯-5¡¯ exonuclease RNase R and 2) Sanger sequencing of PCR amplicons to confirm the sequence of predicted head-to-tail splice junctions. With these assays we validated 7/7 tested candidates suggesting that the overall false positive rate in our data sets is low. qRT-PCR human blood circRNA6 circRNA homo sapiens 26485708 Identification and Characterization of Circular RNAs As a New Class of Putative Biomarkers in Human Blood. Memczak S, Papavasileiou P, Peters O, Rajewsky N. PLoS One. 2015 For the remaining seven circRNA candidates, we tested circularity using previously established assays: 1) resistance to the 3¡¯-5¡¯ exonuclease RNase R and 2) Sanger sequencing of PCR amplicons to confirm the sequence of predicted head-to-tail splice junctions. With these assays we validated 7/7 tested candidates suggesting that the overall false positive rate in our data sets is low. qRT-PCR human blood circRNA7 circRNA homo sapiens 26485708 Identification and Characterization of Circular RNAs As a New Class of Putative Biomarkers in Human Blood. Memczak S, Papavasileiou P, Peters O, Rajewsky N. PLoS One. 2015 For the remaining seven circRNA candidates, we tested circularity using previously established assays: 1) resistance to the 3¡¯-5¡¯ exonuclease RNase R and 2) Sanger sequencing of PCR amplicons to confirm the sequence of predicted head-to-tail splice junctions. With these assays we validated 7/7 tested candidates suggesting that the overall false positive rate in our data sets is low. qRT-PCR human blood circRNA1 circRNA homo sapiens 26485708 Identification and Characterization of Circular RNAs As a New Class of Putative Biomarkers in Human Blood. Memczak S, Papavasileiou P, Peters O, Rajewsky N. PLoS One. 2015 For the remaining seven circRNA candidates, we tested circularity using previously established assays: 1) resistance to the 3¡¯-5¡¯ exonuclease RNase R and 2) Sanger sequencing of PCR amplicons to confirm the sequence of predicted head-to-tail splice junctions. With these assays we validated 7/7 tested candidates suggesting that the overall false positive rate in our data sets is low. qRT-PCR human blood circRNA2 circRNA homo sapiens 26485708 Identification and Characterization of Circular RNAs As a New Class of Putative Biomarkers in Human Blood. Memczak S, Papavasileiou P, Peters O, Rajewsky N. PLoS One. 2015 For the remaining seven circRNA candidates, we tested circularity using previously established assays: 1) resistance to the 3¡¯-5¡¯ exonuclease RNase R and 2) Sanger sequencing of PCR amplicons to confirm the sequence of predicted head-to-tail splice junctions. With these assays we validated 7/7 tested candidates suggesting that the overall false positive rate in our data sets is low. qRT-PCR human blood circRNA3 circRNA homo sapiens 26485708 Identification and Characterization of Circular RNAs As a New Class of Putative Biomarkers in Human Blood. Memczak S, Papavasileiou P, Peters O, Rajewsky N. PLoS One. 2015 For the remaining seven circRNA candidates, we tested circularity using previously established assays: 1) resistance to the 3¡¯-5¡¯ exonuclease RNase R and 2) Sanger sequencing of PCR amplicons to confirm the sequence of predicted head-to-tail splice junctions. With these assays we validated 7/7 tested candidates suggesting that the overall false positive rate in our data sets is low. qRT-PCR human blood circCOL3A1-859267 circRNA homo sapiens COL3A1 photoaging 28286269 Circular RNA profiling reveals that circCOL3A1-859267 regulate type I collagen expression in photoaged human dermal fibroblasts. Peng Y, Song X, Zheng Y, Wang X, Lai W. Biochem Biophys Res Commun. 2017 Consistent with the high throughput sequencing data, the expression of circCOL3A1-859267 in UVA group showed a 2.17 ¡À 0.02 to 14.29 ¡À 0.005 fold decrease as compared with the control group (P < 0.01). qRT-PCR, RNA-seq human dermal fibroblasts Overexpression of circCOL3A1-859267 inhibited UVA-induced decrease of type I collagen expression and silencing of it reduced type I collagen intensity. loss of function, gain of function human dermal fibroblasts circCOL1A2-048810 circRNA homo sapiens COL1A2 photoaging 28286269 Circular RNA profiling reveals that circCOL3A1-859267 regulate type I collagen expression in photoaged human dermal fibroblasts. Peng Y, Song X, Zheng Y, Wang X, Lai W. Biochem Biophys Res Commun. 2017 As expected, the expression of circCOL1A2-048810 increased to 1.41 ¡À 0.02 to 2.38 ¡À 0.05 fold in UVA treated HDFs (P < 0.05). qRT-PCR, RNA-seq human dermal fibroblasts circCDYL circRNA homo sapiens CDYL cardiovascular diseases 28676412 Identification of circular RNAs with host gene-independent expression in human model systems for cardiac differentiation and disease. Siede D, Rapti K, Gorska AA, Katus HA, Altmüller J, Boeckel JN, Meder B, Maack C, Völkers M, Müller OJ, Backs J, Dieterich C. J Mol Cell Cardiol. 2017 We validated this expression profile by qRT-PCR and show that the ratio of ¦¤circRNA to (¦¤circRNA + ¦¤linearRNA) rises for circCDYL during development. qRT-PCR human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs), H7 hESC cells circSMARCA5 circRNA homo sapiens SMARCA5 cardiovascular diseases 28676412 Identification of circular RNAs with host gene-independent expression in human model systems for cardiac differentiation and disease. Siede D, Rapti K, Gorska AA, Katus HA, Altmüller J, Boeckel JN, Meder B, Maack C, Völkers M, Müller OJ, Backs J, Dieterich C. J Mol Cell Cardiol. 2017 We validated this expression profile by qRT-PCR and show that the ratio of ¦¤circRNA to (¦¤circRNA + ¦¤linearRNA) rises for circSMARCA5 during development. qRT-PCR human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs), H7 hESC cells circAASS circRNA homo sapiens AASS 29523209 Signature of circular RNAs in human induced pluripotent stem cells and derived cardiomyocytes. Lei W, Feng T, Fang X, Yu Y, Yang J, Zhao ZA, Liu J, Shen Z, Deng W, Hu S. Stem Cell Res Ther. 2018 circAASS was obviously decreased in hiPSC-CMs and fibroblasts compared to both hESC and hiPSC groups. RNA-seq, qRT-PCR human induced pluripotent stem cells (hiPSCs) and hiPSCderived cardiomyocytes (hiPSC-CMs) circARID1A circRNA homo sapiens ARID1A 29523209 Signature of circular RNAs in human induced pluripotent stem cells and derived cardiomyocytes. Lei W, Feng T, Fang X, Yu Y, Yang J, Zhao ZA, Liu J, Shen Z, Deng W, Hu S. Stem Cell Res Ther. 2018 circARID1A was highly enriched in hiPSC-derived CMs RNA-seq, qRT-PCR human induced pluripotent stem cells (hiPSCs) and hiPSCderived cardiomyocytes (hiPSC-CMs) circFIRRE circRNA homo sapiens FIRRE 29523209 Signature of circular RNAs in human induced pluripotent stem cells and derived cardiomyocytes. Lei W, Feng T, Fang X, Yu Y, Yang J, Zhao ZA, Liu J, Shen Z, Deng W, Hu S. Stem Cell Res Ther. 2018 circFIRRE was obviously decreased in hiPSC-CMs and fibroblasts compared to both hESC and hiPSC groups. RNA-seq, qRT-PCR human induced pluripotent stem cells (hiPSCs) and hiPSCderived cardiomyocytes (hiPSC-CMs) circFNDC3B circRNA homo sapiens FNDC3B 29523209 Signature of circular RNAs in human induced pluripotent stem cells and derived cardiomyocytes. Lei W, Feng T, Fang X, Yu Y, Yang J, Zhao ZA, Liu J, Shen Z, Deng W, Hu S. Stem Cell Res Ther. 2018 circFNDC3B was highly enriched in hiPSC-derived CMs. circFNDC3B transcripts were obviously increased in differentiated cardiomyocytes from day 9. RNA-seq, qRT-PCR human induced pluripotent stem cells (hiPSCs) and hiPSCderived cardiomyocytes (hiPSC-CMs) circTMEFF1 circRNA homo sapiens TMEFF1 29523209 Signature of circular RNAs in human induced pluripotent stem cells and derived cardiomyocytes. Lei W, Feng T, Fang X, Yu Y, Yang J, Zhao ZA, Liu J, Shen Z, Deng W, Hu S. Stem Cell Res Ther. 2018 circTMEFF1 was obviously decreased in hiPSC-CMs and fibroblasts compared to both hESC and hiPSC groups. RNA-seq, qRT-PCR human induced pluripotent stem cells (hiPSCs) and hiPSCderived cardiomyocytes (hiPSC-CMs) circALPK2 circRNA homo sapiens ALPK2 29523209 Signature of circular RNAs in human induced pluripotent stem cells and derived cardiomyocytes. Lei W, Feng T, Fang X, Yu Y, Yang J, Zhao ZA, Liu J, Shen Z, Deng W, Hu S. Stem Cell Res Ther. 2018 circALPK2 was highly enriched in hiPSC-derived CMs. Abundant expression of circALPK2 was observed in cells on day 4 onward of cardiac differentiation. circALPK2 displayed a significantly higher expression in fetal heart. RNA-seq, qRT-PCR human induced pluripotent stem cells (hiPSCs) and hiPSCderived cardiomyocytes (hiPSC-CMs), human fetal heart circCACNA1D circRNA homo sapiens CACNA1D 29523209 Signature of circular RNAs in human induced pluripotent stem cells and derived cardiomyocytes. Lei W, Feng T, Fang X, Yu Y, Yang J, Zhao ZA, Liu J, Shen Z, Deng W, Hu S. Stem Cell Res Ther. 2018 circCACNA1D was highly enriched in hiPSC-derived CMs. circCACNA1D was highly expressed in the beating cardiomyocytes on days 9, 15 and 30 of cardiac differentiation. circCACNA1D displayed a significantly higher expression in fetal heart. RNA-seq, qRT-PCR human induced pluripotent stem cells (hiPSCs) and hiPSCderived cardiomyocytes (hiPSC-CMs), human fetal heart circSPHKAP circRNA homo sapiens SPHKAP 29523209 Signature of circular RNAs in human induced pluripotent stem cells and derived cardiomyocytes. Lei W, Feng T, Fang X, Yu Y, Yang J, Zhao ZA, Liu J, Shen Z, Deng W, Hu S. Stem Cell Res Ther. 2018 circSPHKAP was highly enriched in hiPSC-derived CMs. circSPHKAP was highly expressed in the beating cardiomyocytes on days 9, 15 and 30 of cardiac differentiation.circSPHKAP displayed a significantly higher expression in fetal heart. RNA-seq, qRT-PCR human induced pluripotent stem cells (hiPSCs) and hiPSCderived cardiomyocytes (hiPSC-CMs), human fetal heart circSLC8A1 circRNA homo sapiens SLC8A1 29523209 Signature of circular RNAs in human induced pluripotent stem cells and derived cardiomyocytes. Lei W, Feng T, Fang X, Yu Y, Yang J, Zhao ZA, Liu J, Shen Z, Deng W, Hu S. Stem Cell Res Ther. 2018 circSLC8A1 was highly enriched in hiPSC-derived CMs. circSLC8A1 was highly expressed in the beating cardiomyocytes on days 9, 15 and 30 of cardiac differentiation. circSLC8A1 displayed a significantly higher expression in fetal heart. circSLC8A1 expression was significantly increased in the DCM group. RNA-seq, qRT-PCR human induced pluripotent stem cells (hiPSCs) and hiPSCderived cardiomyocytes (hiPSC-CMs), human fetal heart, heart tissues of healthy individuals and patients suffering from dilated cardiomyopathy (DCM). circALPK2-2 circRNA homo sapiens ALPK2 28082450 A landscape of circular RNA expression in the human heart. Tan WL, Lim BT, Anene-Nzelu CG, Ackers-Johnson M, Dashi A, See K, Tiang Z, Lee DP, Chua WW, Luu TD, Li PY, Richards AM, Foo RS. Cardiovasc Res. 2017 we definitively confirmed the back-spliced structure of 24/30 and 19/20 of human and mouse cardiac circRNA candidates by RT-PCR using junction-specific divergent primers and Sanger sequencing. qRT-PCR human left ventricular (LV) samples circCACNA1C-12 circRNA homo sapiens CACNA1C 28082450 A landscape of circular RNA expression in the human heart. Tan WL, Lim BT, Anene-Nzelu CG, Ackers-Johnson M, Dashi A, See K, Tiang Z, Lee DP, Chua WW, Luu TD, Li PY, Richards AM, Foo RS. Cardiovasc Res. 2017 we definitively confirmed the back-spliced structure of 24/30 and 19/20 of human and mouse cardiac circRNA candidates by RT-PCR using junction-specific divergent primers and Sanger sequencing. qRT-PCR human left ventricular (LV) samples circFAT1-1 circRNA homo sapiens FAT1 28082450 A landscape of circular RNA expression in the human heart. Tan WL, Lim BT, Anene-Nzelu CG, Ackers-Johnson M, Dashi A, See K, Tiang Z, Lee DP, Chua WW, Luu TD, Li PY, Richards AM, Foo RS. Cardiovasc Res. 2017 we definitively confirmed the back-spliced structure of 24/30 and 19/20 of human and mouse cardiac circRNA candidates by RT-PCR using junction-specific divergent primers and Sanger sequencing. qRT-PCR human left ventricular (LV) samples circHIPK2-3 circRNA homo sapiens HIPK2 28082450 A landscape of circular RNA expression in the human heart. Tan WL, Lim BT, Anene-Nzelu CG, Ackers-Johnson M, Dashi A, See K, Tiang Z, Lee DP, Chua WW, Luu TD, Li PY, Richards AM, Foo RS. Cardiovasc Res. 2017 we definitively confirmed the back-spliced structure of 24/30 and 19/20 of human and mouse cardiac circRNA candidates by RT-PCR using junction-specific divergent primers and Sanger sequencing. qRT-PCR human left ventricular (LV) samples circLAMA2-34 circRNA homo sapiens LAMA2 28082450 A landscape of circular RNA expression in the human heart. Tan WL, Lim BT, Anene-Nzelu CG, Ackers-Johnson M, Dashi A, See K, Tiang Z, Lee DP, Chua WW, Luu TD, Li PY, Richards AM, Foo RS. Cardiovasc Res. 2017 we definitively confirmed the back-spliced structure of 24/30 and 19/20 of human and mouse cardiac circRNA candidates by RT-PCR using junction-specific divergent primers and Sanger sequencing. qRT-PCR human left ventricular (LV) samples circPCM1-7 circRNA homo sapiens PCM1 28082450 A landscape of circular RNA expression in the human heart. Tan WL, Lim BT, Anene-Nzelu CG, Ackers-Johnson M, Dashi A, See K, Tiang Z, Lee DP, Chua WW, Luu TD, Li PY, Richards AM, Foo RS. Cardiovasc Res. 2017 we definitively confirmed the back-spliced structure of 24/30 and 19/20 of human and mouse cardiac circRNA candidates by RT-PCR using junction-specific divergent primers and Sanger sequencing. qRT-PCR human left ventricular (LV) samples circRBM20-2 circRNA homo sapiens RBM20 28082450 A landscape of circular RNA expression in the human heart. Tan WL, Lim BT, Anene-Nzelu CG, Ackers-Johnson M, Dashi A, See K, Tiang Z, Lee DP, Chua WW, Luu TD, Li PY, Richards AM, Foo RS. Cardiovasc Res. 2017 we definitively confirmed the back-spliced structure of 24/30 and 19/20 of human and mouse cardiac circRNA candidates by RT-PCR using junction-specific divergent primers and Sanger sequencing. qRT-PCR human left ventricular (LV) samples circSLC8A1-1 circRNA homo sapiens SLC8A1 28082450 A landscape of circular RNA expression in the human heart. Tan WL, Lim BT, Anene-Nzelu CG, Ackers-Johnson M, Dashi A, See K, Tiang Z, Lee DP, Chua WW, Luu TD, Li PY, Richards AM, Foo RS. Cardiovasc Res. 2017 we definitively confirmed the back-spliced structure of 24/30 and 19/20 of human and mouse cardiac circRNA candidates by RT-PCR using junction-specific divergent primers and Sanger sequencing. qRT-PCR human left ventricular (LV) samples circSMARCA5-3 circRNA homo sapiens SMARCA5 28082450 A landscape of circular RNA expression in the human heart. Tan WL, Lim BT, Anene-Nzelu CG, Ackers-Johnson M, Dashi A, See K, Tiang Z, Lee DP, Chua WW, Luu TD, Li PY, Richards AM, Foo RS. Cardiovasc Res. 2017 we definitively confirmed the back-spliced structure of 24/30 and 19/20 of human and mouse cardiac circRNA candidates by RT-PCR using junction-specific divergent primers and Sanger sequencing. qRT-PCR human left ventricular (LV) samples circTTN-354 circRNA homo sapiens TTN 28082450 A landscape of circular RNA expression in the human heart. Tan WL, Lim BT, Anene-Nzelu CG, Ackers-Johnson M, Dashi A, See K, Tiang Z, Lee DP, Chua WW, Luu TD, Li PY, Richards AM, Foo RS. Cardiovasc Res. 2017 we definitively confirmed the back-spliced structure of 24/30 and 19/20 of human and mouse cardiac circRNA candidates by RT-PCR using junction-specific divergent primers and Sanger sequencing. qRT-PCR human left ventricular (LV) samples circTTN-366 circRNA homo sapiens TTN 28082450 A landscape of circular RNA expression in the human heart. Tan WL, Lim BT, Anene-Nzelu CG, Ackers-Johnson M, Dashi A, See K, Tiang Z, Lee DP, Chua WW, Luu TD, Li PY, Richards AM, Foo RS. Cardiovasc Res. 2017 we definitively confirmed the back-spliced structure of 24/30 and 19/20 of human and mouse cardiac circRNA candidates by RT-PCR using junction-specific divergent primers and Sanger sequencing. qRT-PCR human left ventricular (LV) samples Circ-ACVR2A circRNA homo sapiens ACVR2A Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR human myoblasts Circ-ADAMTS6 circRNA homo sapiens ADAMTS6 Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR human myoblasts Circ-ANKIB1 circRNA homo sapiens ANKIB1 Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR human myoblasts Circ-ASH1L circRNA homo sapiens ASH1L Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR human myoblasts Circ-ASPH circRNA homo sapiens ASPH Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR human myoblasts Circ-BACH1 circRNA homo sapiens BACH1 Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR human myoblasts Circ-BNC2 circRNA homo sapiens BNC2 Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR human myoblasts Circ-CAMSAP1 circRNA homo sapiens CAMSAP1 Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR human myoblasts Circ-CDYL circRNA homo sapiens CDYL Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR human myoblasts Circ-CRKL circRNA homo sapiens CRKL Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR human myoblasts Circ-DCBLD2 circRNA homo sapiens DCBLD2 Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR human myoblasts Circ-HIPK3 circRNA homo sapiens HIPK3 Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR human myoblasts Circ-MED13L circRNA homo sapiens MED13L Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR human myoblasts Circ-MEF2A circRNA homo sapiens MEF2A Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR human myoblasts Circ-NEB circRNA homo sapiens NEB Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR human myoblasts Circ-PMS1 circRNA homo sapiens PMS1 Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR human myoblasts Circ-PTP4A2 circRNA homo sapiens PTP4A2 Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR human myoblasts Circ-QKI circRNA homo sapiens QKI Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR human myoblasts Circ-RTN4 circRNA homo sapiens RTN4 Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR human myoblasts Circ-RTN4bis circRNA homo sapiens Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR human myoblasts Circ-RUNX1 circRNA homo sapiens RUNX1 Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR human myoblasts Circ-SEPT9 circRNA homo sapiens SEPT9 Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR human myoblasts Circ-SLC8A1 circRNA homo sapiens SLC8A1 Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR human myoblasts Circ-SPECC1 circRNA homo sapiens SPECC1 Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR human myoblasts Circ-TMEFF1 circRNA homo sapiens TMEFF1 Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR human myoblasts Circ-TTN circRNA homo sapiens TTN Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR human myoblasts Circ-TTTY16 circRNA homo sapiens TTTY16 Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR human myoblasts Circ-ZFHX3 circRNA homo sapiens ZFHX3 Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR human myoblasts Circ-ZNF292 circRNA homo sapiens ZNF292 Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR human myoblasts circ_DMD exon 55-42 circRNA homo sapiens DMD 27754374 Endogenous Multiple Exon Skipping and Back-Splicing at the DMD Mutation Hotspot. Suzuki H, Aoki Y, Kameyama T, Saito T, Masuda S, Tanihata J, Nagata T, Mayeda A, Takeda S, Tsukahara T. Int J Mol Sci. 2016 CircRNA products as by-products of multiple exon-skipping products. RT-PCR human normal skeletal muscle circ_DMD exon 55-45 circRNA homo sapiens DMD 27754374 Endogenous Multiple Exon Skipping and Back-Splicing at the DMD Mutation Hotspot. Suzuki H, Aoki Y, Kameyama T, Saito T, Masuda S, Tanihata J, Nagata T, Mayeda A, Takeda S, Tsukahara T. Int J Mol Sci. 2016 CircRNA products as by-products of multiple exon-skipping products. RT-PCR human normal skeletal muscle circ_DMD exon 57-45 circRNA homo sapiens DMD 27754374 Endogenous Multiple Exon Skipping and Back-Splicing at the DMD Mutation Hotspot. Suzuki H, Aoki Y, Kameyama T, Saito T, Masuda S, Tanihata J, Nagata T, Mayeda A, Takeda S, Tsukahara T. Int J Mol Sci. 2016 CircRNA products as by-products of multiple exon-skipping products. RT-PCR human normal skeletal muscle circ_DMD exon 59-45 circRNA homo sapiens DMD 27754374 Endogenous Multiple Exon Skipping and Back-Splicing at the DMD Mutation Hotspot. Suzuki H, Aoki Y, Kameyama T, Saito T, Masuda S, Tanihata J, Nagata T, Mayeda A, Takeda S, Tsukahara T. Int J Mol Sci. 2016 CircRNA products as by-products of multiple exon-skipping products. RT-PCR human normal skeletal muscle circ_DMD exon 60-42 circRNA homo sapiens DMD 27754374 Endogenous Multiple Exon Skipping and Back-Splicing at the DMD Mutation Hotspot. Suzuki H, Aoki Y, Kameyama T, Saito T, Masuda S, Tanihata J, Nagata T, Mayeda A, Takeda S, Tsukahara T. Int J Mol Sci. 2016 CircRNA products as by-products of multiple exon-skipping products. RT-PCR human normal skeletal muscle circ_DMD exon 60-45 circRNA homo sapiens DMD 27754374 Endogenous Multiple Exon Skipping and Back-Splicing at the DMD Mutation Hotspot. Suzuki H, Aoki Y, Kameyama T, Saito T, Masuda S, Tanihata J, Nagata T, Mayeda A, Takeda S, Tsukahara T. Int J Mol Sci. 2016 CircRNA products as by-products of multiple exon-skipping products. RT-PCR human normal skeletal muscle circ_DMD exon 60-48 circRNA homo sapiens DMD 27754374 Endogenous Multiple Exon Skipping and Back-Splicing at the DMD Mutation Hotspot. Suzuki H, Aoki Y, Kameyama T, Saito T, Masuda S, Tanihata J, Nagata T, Mayeda A, Takeda S, Tsukahara T. Int J Mol Sci. 2016 CircRNA products as by-products of multiple exon-skipping products. RT-PCR human normal skeletal muscle circ_DMD exon 60-50 circRNA homo sapiens DMD 27754374 Endogenous Multiple Exon Skipping and Back-Splicing at the DMD Mutation Hotspot. Suzuki H, Aoki Y, Kameyama T, Saito T, Masuda S, Tanihata J, Nagata T, Mayeda A, Takeda S, Tsukahara T. Int J Mol Sci. 2016 CircRNA products as by-products of multiple exon-skipping products. RT-PCR human normal skeletal muscle circRNA_000167 circRNA homo sapiens Esophageal cancer 27465405 Profiling and bioinformatics analyses reveal differential circular RNA expression in radioresistant esophageal cancer cells. Su H, Lin F, Deng X, Shen L, Fang Y, Fei Z, Zhao L, Zhang X, Pan H, Xie D, Jin X, Xie C. J Transl Med. 2016 down microarray, qRT-PCR human radioresistant esophageal cancer cell line KYSE-150R and KYSE-150 circRNA_000695 circRNA homo sapiens Esophageal cancer 27465405 Profiling and bioinformatics analyses reveal differential circular RNA expression in radioresistant esophageal cancer cells. Su H, Lin F, Deng X, Shen L, Fang Y, Fei Z, Zhao L, Zhang X, Pan H, Xie D, Jin X, Xie C. J Transl Med. 2016 down microarray, qRT-PCR human radioresistant esophageal cancer cell line KYSE-150R and KYSE-150 circRNA_101419 circRNA homo sapiens Esophageal cancer 27465405 Profiling and bioinformatics analyses reveal differential circular RNA expression in radioresistant esophageal cancer cells. Su H, Lin F, Deng X, Shen L, Fang Y, Fei Z, Zhao L, Zhang X, Pan H, Xie D, Jin X, Xie C. J Transl Med. 2016 down microarray, qRT-PCR human radioresistant esophageal cancer cell line KYSE-150R and KYSE-150 circRNA_101877 circRNA homo sapiens Esophageal cancer 27465405 Profiling and bioinformatics analyses reveal differential circular RNA expression in radioresistant esophageal cancer cells. Su H, Lin F, Deng X, Shen L, Fang Y, Fei Z, Zhao L, Zhang X, Pan H, Xie D, Jin X, Xie C. J Transl Med. 2016 down microarray, qRT-PCR human radioresistant esophageal cancer cell line KYSE-150R and KYSE-150 circRNA_102913 circRNA homo sapiens Esophageal cancer 27465405 Profiling and bioinformatics analyses reveal differential circular RNA expression in radioresistant esophageal cancer cells. Su H, Lin F, Deng X, Shen L, Fang Y, Fei Z, Zhao L, Zhang X, Pan H, Xie D, Jin X, Xie C. J Transl Med. 2016 down microarray, qRT-PCR human radioresistant esophageal cancer cell line KYSE-150R and KYSE-150 circRNA_001059 circRNA homo sapiens Esophageal cancer 27465405 Profiling and bioinformatics analyses reveal differential circular RNA expression in radioresistant esophageal cancer cells. Su H, Lin F, Deng X, Shen L, Fang Y, Fei Z, Zhao L, Zhang X, Pan H, Xie D, Jin X, Xie C. J Transl Med. 2016 up microarray, qRT-PCR human radioresistant esophageal cancer cell line KYSE-150R and KYSE-150 circRNA_100367 circRNA homo sapiens Esophageal cancer 27465405 Profiling and bioinformatics analyses reveal differential circular RNA expression in radioresistant esophageal cancer cells. Su H, Lin F, Deng X, Shen L, Fang Y, Fei Z, Zhao L, Zhang X, Pan H, Xie D, Jin X, Xie C. J Transl Med. 2016 up microarray, qRT-PCR human radioresistant esophageal cancer cell line KYSE-150R and KYSE-150 circRNA_100984 circRNA homo sapiens Esophageal cancer 27465405 Profiling and bioinformatics analyses reveal differential circular RNA expression in radioresistant esophageal cancer cells. Su H, Lin F, Deng X, Shen L, Fang Y, Fei Z, Zhao L, Zhang X, Pan H, Xie D, Jin X, Xie C. J Transl Med. 2016 up microarray, qRT-PCR human radioresistant esophageal cancer cell line KYSE-150R and KYSE-150 circRNA_104983 circRNA homo sapiens Esophageal cancer 27465405 Profiling and bioinformatics analyses reveal differential circular RNA expression in radioresistant esophageal cancer cells. Su H, Lin F, Deng X, Shen L, Fang Y, Fei Z, Zhao L, Zhang X, Pan H, Xie D, Jin X, Xie C. J Transl Med. 2016 up microarray, qRT-PCR human radioresistant esophageal cancer cell line KYSE-150R and KYSE-150 circ-GSE1 circRNA homo sapiens GSE1 26138677 Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis. Li Y, Zheng Q, Bao C, Li S, Guo W, Zhao J, Chen D, Gu J, He X, Huang S. Cell Res. 2015 detected in serum-derived exosomes RNA-seq, qRT-PCR human serum-derived exosomes circ-N4BP2L2 circRNA homo sapiens N4BP2L2 26138677 Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis. Li Y, Zheng Q, Bao C, Li S, Guo W, Zhao J, Chen D, Gu J, He X, Huang S. Cell Res. 2015 detected in serum-derived exosomes RNA-seq, qRT-PCR human serum-derived exosomes circ-SMARCA5 circRNA homo sapiens SMARCA5 26138677 Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis. Li Y, Zheng Q, Bao C, Li S, Guo W, Zhao J, Chen D, Gu J, He X, Huang S. Cell Res. 2015 detected in serum-derived exosomes RNA-seq, qRT-PCR human serum-derived exosomes circADD3:chr10:111878345-111886261 circRNA homo sapiens ADD3 male infertile diseases 27958373 Identification and characterization of human testis derived circular RNAs and their existence in seminal plasma. Dong WW, Li HM, Qing XR, Huang DH, Li HG. Sci Rep. 2016 To validate these predicted circRNAs, 55 circRNAs of different abundance and lengths were randomly chosen for subsequent RT-PCR validation. Divergent primers were designed for circRNA detection. Among the 55 circRNAs, 30 of them could be specifically amplified. qRT-PCR human testis circBRDT:chr1:92428275-92430321 circRNA homo sapiens BRDT male infertile diseases 27958373 Identification and characterization of human testis derived circular RNAs and their existence in seminal plasma. Dong WW, Li HM, Qing XR, Huang DH, Li HG. Sci Rep. 2016 To validate these predicted circRNAs, 55 circRNAs of different abundance and lengths were randomly chosen for subsequent RT-PCR validation. Divergent primers were designed for circRNA detection. Among the 55 circRNAs, 30 of them could be specifically amplified. qRT-PCR human testis circBRDT:chr1:92428275-92433817 circRNA homo sapiens BRDT male infertile diseases 27958373 Identification and characterization of human testis derived circular RNAs and their existence in seminal plasma. Dong WW, Li HM, Qing XR, Huang DH, Li HG. Sci Rep. 2016 To validate these predicted circRNAs, 55 circRNAs of different abundance and lengths were randomly chosen for subsequent RT-PCR validation. Divergent primers were designed for circRNA detection. Among the 55 circRNAs, 30 of them could be specifically amplified. qRT-PCR human testis circBRDT:chr1:92446446-92446735 circRNA homo sapiens BRDT male infertile diseases 27958373 Identification and characterization of human testis derived circular RNAs and their existence in seminal plasma. Dong WW, Li HM, Qing XR, Huang DH, Li HG. Sci Rep. 2016 To validate these predicted circRNAs, 55 circRNAs of different abundance and lengths were randomly chosen for subsequent RT-PCR validation. Divergent primers were designed for circRNA detection. Among the 55 circRNAs, 30 of them could be specifically amplified. qRT-PCR human testis circHIST1H2BA:chr6:25727079-25727268 circRNA homo sapiens HIST1H2BA male infertile diseases 27958373 Identification and characterization of human testis derived circular RNAs and their existence in seminal plasma. Dong WW, Li HM, Qing XR, Huang DH, Li HG. Sci Rep. 2016 To validate these predicted circRNAs, 55 circRNAs of different abundance and lengths were randomly chosen for subsequent RT-PCR validation. Divergent primers were designed for circRNA detection. Among the 55 circRNAs, 30 of them could be specifically amplified. qRT-PCR human testis circRNF17:chr13:25341410-25356082 circRNA homo sapiens RNF17 male infertile diseases 27958373 Identification and characterization of human testis derived circular RNAs and their existence in seminal plasma. Dong WW, Li HM, Qing XR, Huang DH, Li HG. Sci Rep. 2016 To validate these predicted circRNAs, 55 circRNAs of different abundance and lengths were randomly chosen for subsequent RT-PCR validation. Divergent primers were designed for circRNA detection. Among the 55 circRNAs, 30 of them could be specifically amplified. qRT-PCR human testis circSMC1B:chr22:45749858-45750995 circRNA homo sapiens SMC1B male infertile diseases 27958373 Identification and characterization of human testis derived circular RNAs and their existence in seminal plasma. Dong WW, Li HM, Qing XR, Huang DH, Li HG. Sci Rep. 2016 To validate these predicted circRNAs, 55 circRNAs of different abundance and lengths were randomly chosen for subsequent RT-PCR validation. Divergent primers were designed for circRNA detection. Among the 55 circRNAs, 30 of them could be specifically amplified. qRT-PCR human testis circSPATA16:chr3:172694758-172766884 circRNA homo sapiens SPATA16 male infertile diseases 27958373 Identification and characterization of human testis derived circular RNAs and their existence in seminal plasma. Dong WW, Li HM, Qing XR, Huang DH, Li HG. Sci Rep. 2016 To validate these predicted circRNAs, 55 circRNAs of different abundance and lengths were randomly chosen for subsequent RT-PCR validation. Divergent primers were designed for circRNA detection. Among the 55 circRNAs, 30 of them could be specifically amplified. qRT-PCR human testis circSTK31:chr13:23751718-23776697 circRNA homo sapiens STK31 male infertile diseases 27958373 Identification and characterization of human testis derived circular RNAs and their existence in seminal plasma. Dong WW, Li HM, Qing XR, Huang DH, Li HG. Sci Rep. 2016 To validate these predicted circRNAs, 55 circRNAs of different abundance and lengths were randomly chosen for subsequent RT-PCR validation. Divergent primers were designed for circRNA detection. Among the 55 circRNAs, 30 of them could be specifically amplified. qRT-PCR human testis circSTK31:chr13:23792336-23794093 circRNA homo sapiens STK31 male infertile diseases 27958373 Identification and characterization of human testis derived circular RNAs and their existence in seminal plasma. Dong WW, Li HM, Qing XR, Huang DH, Li HG. Sci Rep. 2016 To validate these predicted circRNAs, 55 circRNAs of different abundance and lengths were randomly chosen for subsequent RT-PCR validation. Divergent primers were designed for circRNA detection. Among the 55 circRNAs, 30 of them could be specifically amplified. qRT-PCR human testis circTEX14:chr17:56690782-56693666 circRNA homo sapiens TEX14 male infertile diseases 27958373 Identification and characterization of human testis derived circular RNAs and their existence in seminal plasma. Dong WW, Li HM, Qing XR, Huang DH, Li HG. Sci Rep. 2016 To validate these predicted circRNAs, 55 circRNAs of different abundance and lengths were randomly chosen for subsequent RT-PCR validation. Divergent primers were designed for circRNA detection. Among the 55 circRNAs, 30 of them could be specifically amplified. qRT-PCR human testis hsa_circRNA_005525 circRNA homo sapiens thoracic aortic dissection 29137225 Circular RNA expression profile and potential function of hsa_circRNA_101238 in human thoracic aortic dissection. Zou M, Huang C, Li X, He X, Chen Y, Liao W, Liao Y, Sun J, Liu Z, Zhong L, Bin J. Oncotarget. 2017 Downregulated in human thoracic aortic dissection compared to age-matched normal donors. microarray, qRT-PCR human thoracic aortic dissection and age-matched normal donors hsa_circRNA_102683 circRNA homo sapiens thoracic aortic dissection 29137225 Circular RNA expression profile and potential function of hsa_circRNA_101238 in human thoracic aortic dissection. Zou M, Huang C, Li X, He X, Chen Y, Liao W, Liao Y, Sun J, Liu Z, Zhong L, Bin J. Oncotarget. 2017 Downregulated in human thoracic aortic dissection compared to age-matched normal donors. microarray, qRT-PCR human thoracic aortic dissection and age-matched normal donors hsa_circRNA_103458 circRNA homo sapiens thoracic aortic dissection 29137225 Circular RNA expression profile and potential function of hsa_circRNA_101238 in human thoracic aortic dissection. Zou M, Huang C, Li X, He X, Chen Y, Liao W, Liao Y, Sun J, Liu Z, Zhong L, Bin J. Oncotarget. 2017 Downregulated in human thoracic aortic dissection compared to age-matched normal donors. microarray, qRT-PCR human thoracic aortic dissection and age-matched normal donors hsa_circRNA_002271 circRNA homo sapiens thoracic aortic dissection 29137225 Circular RNA expression profile and potential function of hsa_circRNA_101238 in human thoracic aortic dissection. Zou M, Huang C, Li X, He X, Chen Y, Liao W, Liao Y, Sun J, Liu Z, Zhong L, Bin J. Oncotarget. 2017 Upregulated in human thoracic aortic dissection compared to age-matched normal donors. microarray, qRT-PCR human thoracic aortic dissection and age-matched normal donors hsa_circRNA_102771 circRNA homo sapiens thoracic aortic dissection 29137225 Circular RNA expression profile and potential function of hsa_circRNA_101238 in human thoracic aortic dissection. Zou M, Huang C, Li X, He X, Chen Y, Liao W, Liao Y, Sun J, Liu Z, Zhong L, Bin J. Oncotarget. 2017 Upregulated in human thoracic aortic dissection compared to age-matched normal donors. microarray, qRT-PCR human thoracic aortic dissection and age-matched normal donors hsa_circRNA_104349 circRNA homo sapiens thoracic aortic dissection 29137225 Circular RNA expression profile and potential function of hsa_circRNA_101238 in human thoracic aortic dissection. Zou M, Huang C, Li X, He X, Chen Y, Liao W, Liao Y, Sun J, Liu Z, Zhong L, Bin J. Oncotarget. 2017 Upregulated in human thoracic aortic dissection compared to age-matched normal donors. microarray, qRT-PCR human thoracic aortic dissection and age-matched normal donors hsa_circRNA_104634 circRNA homo sapiens thoracic aortic dissection 29137225 Circular RNA expression profile and potential function of hsa_circRNA_101238 in human thoracic aortic dissection. Zou M, Huang C, Li X, He X, Chen Y, Liao W, Liao Y, Sun J, Liu Z, Zhong L, Bin J. Oncotarget. 2017 Upregulated in human thoracic aortic dissection compared to age-matched normal donors. microarray, qRT-PCR human thoracic aortic dissection and age-matched normal donors cFOXJ3 circRNA homo sapiens FOXJ3 26377962 Identification and Characterization of Hypoxia-Regulated Endothelial Circular RNA. Boeckel JN, Jaé N, Heumüller AW, Chen W, Boon RA, Stellos K, Zeiher AM, John D, Uchida S, Dimmeler S. Circ Res. 2015 hypoxia-induced circRNAs qRT-PCR HUVEC cSRSF4 circRNA homo sapiens SRSF4 26377962 Identification and Characterization of Hypoxia-Regulated Endothelial Circular RNA. Boeckel JN, Jaé N, Heumüller AW, Chen W, Boon RA, Stellos K, Zeiher AM, John D, Uchida S, Dimmeler S. Circ Res. 2015 hypoxia-induced circRNAs qRT-PCR HUVEC cTHSD1 circRNA homo sapiens THSD1 26377962 Identification and Characterization of Hypoxia-Regulated Endothelial Circular RNA. Boeckel JN, Jaé N, Heumüller AW, Chen W, Boon RA, Stellos K, Zeiher AM, John D, Uchida S, Dimmeler S. Circ Res. 2015 downregulated after hypoxia RT-PCR, qRT-PCR HUVEC cAFF1 circRNA homo sapiens AFF1 26377962 Identification and Characterization of Hypoxia-Regulated Endothelial Circular RNA. Boeckel JN, Jaé N, Heumüller AW, Chen W, Boon RA, Stellos K, Zeiher AM, John D, Uchida S, Dimmeler S. Circ Res. 2015 hypoxia-induced circRNAs RT-PCR, qRT-PCR HUVEC cDENND4C circRNA homo sapiens DENND4C 26377962 Identification and Characterization of Hypoxia-Regulated Endothelial Circular RNA. Boeckel JN, Jaé N, Heumüller AW, Chen W, Boon RA, Stellos K, Zeiher AM, John D, Uchida S, Dimmeler S. Circ Res. 2015 hypoxia-induced circRNAs RT-PCR, qRT-PCR HUVEC cZNF292 circRNA homo sapiens ZNF292 26377962 Identification and Characterization of Hypoxia-Regulated Endothelial Circular RNA. Boeckel JN, Jaé N, Heumüller AW, Chen W, Boon RA, Stellos K, Zeiher AM, John D, Uchida S, Dimmeler S. Circ Res. 2015 hypoxia-induced circRNAs RT-PCR, qRT-PCR, northern blots HUVEC, HEK-293T cZNF292 Regulates Angiogenic Sprouting loss of function HUVEC hsa_circRNA_100709 circRNA homo sapiens infantile hemangioma 29095957 Circular RNA profile of infantile hemangioma by microarray analysis. Fu C, Lv R, Xu G, Zhang L, Bi J, Lin L, Liu X, Huo R. PLoS One. 2017 up-regulated in IH compared to adjacent skin tissues. microarray, qRT-PCR IH and adjacent skin tissues ciRS-7 circRNA homo sapiens CDR1 Diabetes Mellitus 29396373 Circular RNAs as novel regulators of β-cell functions in normal and disease conditions. Stoll L, Sobel J, Rodriguez-Trejo A, Guay C, Lee K, Venø MT, Kjems J, Laybutt DR, Regazzi R. Mol Metab. 2018 We indeed detected ciRS-7 in the insulin-secreting cell lines INS832/13, and MIN6B1, as well as, in mouse, rat, and human islets. RNA-seq, microarray, qRT-PCR INS832/13, MIN6B1, mouse islets, ratislets, human islets. As we found a reduction in ciRS-7 level in the islets of db/db and ob/ob mice, we reproduced the decreased expression in wild type beta-cells and observed that insulin secretion tends to be reduced (p = 0.058) while insulin content is unaffected. Alterations of ciRS-7 levels under diabetic conditions may contribute to beta-cell dysfunction. loss of function beta-cells, MIN6B1 cells the islets of db/db and ob/ob mice circAFF1 circRNA homo sapiens AFF1 Diabetes Mellitus 29396373 Circular RNAs as novel regulators of β-cell functions in normal and disease conditions. Stoll L, Sobel J, Rodriguez-Trejo A, Guay C, Lee K, Venø MT, Kjems J, Laybutt DR, Regazzi R. Mol Metab. 2018 We indeed detected circAFF1 in the insulin-secreting cell lines INS832/13, and MIN6B1, as well as, in mouse, rat, and human islets. RNA-seq, microarray, qRT-PCR INS832/13, MIN6B1, mouse islets, ratislets, human islets. Silencing of circAFF1 in MIN6B1 cells or primary rat beta-cells resulted in an increase in apoptosis comparable to that observed after treatment of the cells with a combination of proinflammatory cytokines. In contrast, circAFF1 silencing did not affect the proliferative capacity of MIN6B1 cells, and did not alter insulin content or secretion in response to glucose of MIN6B1 cells or of primary rat b-cells. loss of function MIN6B1 cells primary rat beta-cells circARHGAP12 circRNA homo sapiens ARHGAP12 Diabetes Mellitus 29396373 Circular RNAs as novel regulators of β-cell functions in normal and disease conditions. Stoll L, Sobel J, Rodriguez-Trejo A, Guay C, Lee K, Venø MT, Kjems J, Laybutt DR, Regazzi R. Mol Metab. 2018 We indeed detected circARHGAP12 in the insulin-secreting cell lines INS832/13, and MIN6B1, as well as, in mouse, rat, and human islets. RNA-seq, microarray, qRT-PCR INS832/13, MIN6B1, mouse islets, ratislets, human islets. circRNA_0001073 circRNA homo sapiens severe acne 29573483 Circular RNA expression profile analysis of severe acne by RNA-seq and bioinformatics. Liang J, Wu X, Sun S, Chen P, Liang X, Wang J, Ruan J, Zhang S, Zhang X. J Eur Acad Dermatol Venereol. 2018 circRNA_0001073 has significant decrease in severe acne by PCR, Sanger sequencing and qRT-PCR, in agreement with the results from RNA-Seq data analysis. PCR, RNA-seq, qRT-PCR lesional skin and adjacent non-lesional skin in severe acne circRNA_0005941 circRNA homo sapiens severe acne 29573483 Circular RNA expression profile analysis of severe acne by RNA-seq and bioinformatics. Liang J, Wu X, Sun S, Chen P, Liang X, Wang J, Ruan J, Zhang S, Zhang X. J Eur Acad Dermatol Venereol. 2018 circRNA_0005941 has significant decrease in severe acne by PCR, Sanger sequencing and qRT-PCR, in agreement with the results from RNA-Seq data analysis. PCR, RNA-seq, qRT-PCR lesional skin and adjacent non-lesional skin in severe acne circRNA_0018168 circRNA homo sapiens severe acne 29573483 Circular RNA expression profile analysis of severe acne by RNA-seq and bioinformatics. Liang J, Wu X, Sun S, Chen P, Liang X, Wang J, Ruan J, Zhang S, Zhang X. J Eur Acad Dermatol Venereol. 2018 circRNA_0018168 has significant decrease in severe acne by PCR, Sanger sequencing and qRT-PCR, in agreement with the results from RNA-Seq data analysis. PCR, RNA-seq, qRT-PCR lesional skin and adjacent non-lesional skin in severe acne circRNA_0084927 circRNA homo sapiens severe acne 29573483 Circular RNA expression profile analysis of severe acne by RNA-seq and bioinformatics. Liang J, Wu X, Sun S, Chen P, Liang X, Wang J, Ruan J, Zhang S, Zhang X. J Eur Acad Dermatol Venereol. 2018 circRNA_0084927 has significant decrease in severe acne by PCR, Sanger sequencing and qRT-PCR, in agreement with the results from RNA-Seq data analysis. PCR, RNA-seq, qRT-PCR lesional skin and adjacent non-lesional skin in severe acne circRNA_0086376 circRNA homo sapiens severe acne 29573483 Circular RNA expression profile analysis of severe acne by RNA-seq and bioinformatics. Liang J, Wu X, Sun S, Chen P, Liang X, Wang J, Ruan J, Zhang S, Zhang X. J Eur Acad Dermatol Venereol. 2018 circRNA_0086376 has significant decrease in severe acne by PCR, Sanger sequencing and qRT-PCR, in agreement with the results from RNA-Seq data analysis. PCR, RNA-seq, qRT-PCR lesional skin and adjacent non-lesional skin in severe acne hsa_circRNA_101368 circRNA homo sapiens FUT8 hepatocellular carcinoma 28727484 Construction and analysis of circular RNA molecular regulatory networks in liver cancer. Ren S, Xin Z, Xu Y, Xu J, Wang G. Cell Cycle. 2017 up microarray, qRT-PCR liver cancer tissues and paired pericancerous tissues ROC plot showed circFUT8 could significantly distinguish the cancer samples, with an AUC of 0.7575. liver cancer tissues hsa_circRNA_103809 circRNA homo sapiens ZFR hepatocellular carcinoma 28727484 Construction and analysis of circular RNA molecular regulatory networks in liver cancer. Ren S, Xin Z, Xu Y, Xu J, Wang G. Cell Cycle. 2017 up microarray, qRT-PCR liver cancer tissues and paired pericancerous tissues ROC plot showed circZFR could significantly distinguish the cancer samples, with an AUC of 0.7069. liver cancer tissues hsa_circRNA_103847 circRNA homo sapiens IPO11 hepatocellular carcinoma 28727484 Construction and analysis of circular RNA molecular regulatory networks in liver cancer. Ren S, Xin Z, Xu Y, Xu J, Wang G. Cell Cycle. 2017 up microarray, qRT-PCR liver cancer tissues and paired pericancerous tissues ROC plot showed circIPO11 could significantly distinguish the cancer samples, with an AUC of 0.7103. liver cancer tissues circ-PRKAR1B circRNA homo sapiens PRKAR1B 29343848 A novel protein encoded by the circular form of the SHPRH gene suppresses glioma tumorigenesis. Zhang M, Huang N, Yang X, Luo J, Yan S, Xiao F, Chen W, Gao X, Zhao K, Zhou H, Li Z, Ming L, Xie B, Zhang N. Oncogene. 2018 downregulated when hnRNP L knockdown RNA-seq, qRT-PCR LNCaP, HEK293T HNRNPL Regulates Circular RNA Formation circ-ZMIZ1 circRNA homo sapiens ZMIZ1 29343848 A novel protein encoded by the circular form of the SHPRH gene suppresses glioma tumorigenesis. Zhang M, Huang N, Yang X, Luo J, Yan S, Xiao F, Chen W, Gao X, Zhao K, Zhou H, Li Z, Ming L, Xie B, Zhang N. Oncogene. 2018 downregulated when hnRNP L knockdown RNA-seq, qRT-PCR LNCaP, HEK294T HNRNPL Regulates Circular RNA Formation circ-FOXJ3 circRNA homo sapiens FOXJ3 29343848 A novel protein encoded by the circular form of the SHPRH gene suppresses glioma tumorigenesis. Zhang M, Huang N, Yang X, Luo J, Yan S, Xiao F, Chen W, Gao X, Zhao K, Zhou H, Li Z, Ming L, Xie B, Zhang N. Oncogene. 2018 downregulated when hnRNP L knockdown RNA-seq, qRT-PCR LNCaP, HEK295T HNRNPL Regulates Circular RNA Formation circ-PPFIA2-1 circRNA homo sapiens PPFIA2-1 29343848 A novel protein encoded by the circular form of the SHPRH gene suppresses glioma tumorigenesis. Zhang M, Huang N, Yang X, Luo J, Yan S, Xiao F, Chen W, Gao X, Zhao K, Zhou H, Li Z, Ming L, Xie B, Zhang N. Oncogene. 2018 upregulated when hnRNP L knockdown RNA-seq, qRT-PCR LNCaP, HEK296T HNRNPL Regulates Circular RNA Formation circ-PPFIA2-2 circRNA homo sapiens PPFIA2-2 29343848 A novel protein encoded by the circular form of the SHPRH gene suppresses glioma tumorigenesis. Zhang M, Huang N, Yang X, Luo J, Yan S, Xiao F, Chen W, Gao X, Zhao K, Zhou H, Li Z, Ming L, Xie B, Zhang N. Oncogene. 2018 upregulated when hnRNP L knockdown RNA-seq, qRT-PCR LNCaP, HEK297T HNRNPL Regulates Circular RNA Formation circ-CCNY circRNA homo sapiens CCNY 29343848 A novel protein encoded by the circular form of the SHPRH gene suppresses glioma tumorigenesis. Zhang M, Huang N, Yang X, Luo J, Yan S, Xiao F, Chen W, Gao X, Zhao K, Zhou H, Li Z, Ming L, Xie B, Zhang N. Oncogene. 2018 upregulated when hnRNP L knockdown RNA-seq, qRT-PCR LNCaP, HEK298T HNRNPL Regulates Circular RNA Formation hsa_circRNA_100855 circRNA homo sapiens Laryngeal squamous cell cancer (LSCC) 27158380 Circular RNA: a novel biomarker for progressive laryngeal cancer. Xuan L, Qu L, Zhou H, Wang P, Yu H, Wu T, Wang X, Li Q, Tian L, Liu M, Sun Y. Am J Transl Res. 2016 significantly higher in LSCC tissues microarray, qRT-PCR, FISH LSCC tissues and corresponding adjacent non-neoplastic tissues Tumors with grade T3 to T4, lymph node metastasis, supraglottic location or advanced clinical stages expressed higher levels of hsa_circRNA_100855. LSCC tissues and corresponding adjacent non-neoplastic tissues hsa_circRNA_104912 circRNA homo sapiens Laryngeal squamous cell cancer (LSCC) 27158380 Circular RNA: a novel biomarker for progressive laryngeal cancer. Xuan L, Qu L, Zhou H, Wang P, Yu H, Wu T, Wang X, Li Q, Tian L, Liu M, Sun Y. Am J Transl Res. 2016 significantly lower in LSCC tissues microarray, qRT-PCR, FISH LSCC tissues and corresponding adjacent non-neoplastic tissues Tumors with grade T3 to T4, lymph node metastasis, poor differentiation or advanced clinical stages expressed lower levels of hsa_circRNA_104912. LSCC tissues and corresponding adjacent non-neoplastic tissues hsa-circRNA-101645 circRNA homo sapiens intervertebral disc degeneration 27542248 Landscape of RNAs in human lumbar disc degeneration. Lan PH, Liu ZH, Pei YJ, Wu ZG, Yu Y, Yang YF, Liu X, Che L, Ma CJ, Xie YK, Hu QJ, Wan ZY, Wang HQ. Oncotarget. 2016 significantly decreased in degenerative samples compared with control. qRT-PCR lumbar disc samples hsa-circRNA-101852 circRNA homo sapiens intervertebral disc degeneration 27542248 Landscape of RNAs in human lumbar disc degeneration. Lan PH, Liu ZH, Pei YJ, Wu ZG, Yu Y, Yang YF, Liu X, Che L, Ma CJ, Xie YK, Hu QJ, Wan ZY, Wang HQ. Oncotarget. 2016 significantly increased in degenerative samples compared with control. qRT-PCR lumbar disc samples circRNA-001489 circRNA homo sapiens macrophage polarization 28075448 Microarray analysis of circular RNA expression patterns in polarized macrophages. Zhang Y, Zhang Y, Li X, Zhang M, Lv K. Int J Mol Med. 2017 downregulated (fold-change >4, P<0.05) in M1 compared to M2, which was found to correlate with the microarray data. qRT-PCR, microarray M1 and M2 macrophages circRNA-003424 circRNA homo sapiens macrophage polarization 28075448 Microarray analysis of circular RNA expression patterns in polarized macrophages. Zhang Y, Zhang Y, Li X, Zhang M, Lv K. Int J Mol Med. 2017 downregulated (fold-change >4, P<0.05) in M1 compared to M2, which was found to correlate with the microarray data. qRT-PCR, microarray M1 and M2 macrophages circRNA-013630 circRNA homo sapiens macrophage polarization 28075448 Microarray analysis of circular RNA expression patterns in polarized macrophages. Zhang Y, Zhang Y, Li X, Zhang M, Lv K. Int J Mol Med. 2017 downregulated (fold-change >4, P<0.05) in M1 compared to M2, which was found to correlate with the microarray data. qRT-PCR, microarray M1 and M2 macrophages circRNA-018127 circRNA homo sapiens macrophage polarization 28075448 Microarray analysis of circular RNA expression patterns in polarized macrophages. Zhang Y, Zhang Y, Li X, Zhang M, Lv K. Int J Mol Med. 2017 downregulated (fold-change >4, P<0.05) in M1 compared to M2, which was found to correlate with the microarray data. qRT-PCR, microarray M1 and M2 macrophages circRNA-003780 circRNA homo sapiens macrophage polarization 28075448 Microarray analysis of circular RNA expression patterns in polarized macrophages. Zhang Y, Zhang Y, Li X, Zhang M, Lv K. Int J Mol Med. 2017 upregulated (fold-change >4, P<0.05) in M1 compared to M2, which was found to correlate with the microarray data. qRT-PCR, microarray M1 and M2 macrophages circRNA-010056 circRNA homo sapiens macrophage polarization 28075448 Microarray analysis of circular RNA expression patterns in polarized macrophages. Zhang Y, Zhang Y, Li X, Zhang M, Lv K. Int J Mol Med. 2017 upregulated (fold-change >4, P<0.05) in M1 compared to M2, which was found to correlate with the microarray data. qRT-PCR, microarray M1 and M2 macrophages circRNA-010231 circRNA homo sapiens macrophage polarization 28075448 Microarray analysis of circular RNA expression patterns in polarized macrophages. Zhang Y, Zhang Y, Li X, Zhang M, Lv K. Int J Mol Med. 2017 upregulated (fold-change >4, P<0.05) in M1 compared to M2, which was found to correlate with the microarray data. qRT-PCR, microarray M1 and M2 macrophages circANRIL circRNA homo sapiens ANRIL Melanoma 28653984 Multiple Isoforms of ANRIL in Melanoma Cells: Structural Complexity Suggests Variations in Processing. Sarkar D, Oghabian A, Bodiyabadu PK, Joseph WR, Leung EY, Finlay GJ, Baguley BC, Askarian-Amiri ME. Int J Mol Sci. 2017 circANRIL was expressed in all the melanoma lines qRT-PCR, RT-PCR and sanger sequencing M3, M6, M7, M21, M25, M37, M40, M42, M44, M48, M53, M55, M70, M71, M76, M87, NZM7 and NZM37 circRNA19 circRNA homo sapiens EMT 28601598 Deep sequencing reveals a global reprogramming of lncRNA transcriptome during EMT. Liao JY, Wu J, Wang YJ, He JH, Deng WX, Hu K, Zhang YC, Zhang Y, Yan H, Wang DL, Liu Q, Zeng MS, Phillip Koeffler H, Song E, Yin D. Biochim Biophys Acta. 2017 Two randomly selected circRNAs were verified using a pair of outward-facing primers using RNA either treated or untreated with RNase R. The RNase can specifically degrade linear but not circular RNA. qPCR analysis paralleled these RNAeSeq results, with expression of the aforementioned two circRNAs gradually upregulated during TGF-¦Â exposure associated with the EMT process. qRT-PCR, RNA-seq MCF10A cells circRNA3 circRNA homo sapiens EMT 28601598 Deep sequencing reveals a global reprogramming of lncRNA transcriptome during EMT. Liao JY, Wu J, Wang YJ, He JH, Deng WX, Hu K, Zhang YC, Zhang Y, Yan H, Wang DL, Liu Q, Zeng MS, Phillip Koeffler H, Song E, Yin D. Biochim Biophys Acta. 2017 Two randomly selected circRNAs were verified using a pair of outward-facing primers using RNA either treated or untreated with RNase R. The RNase can specifically degrade linear but not circular RNA. qPCR analysis paralleled these RNAeSeq results, with expression of the aforementioned two circRNAs gradually upregulated during TGF-¦Â exposure associated with the EMT process. qRT-PCR, RNA-seq MCF10A cells circ_chr14:102,466,325¨C102,500,789 circRNA homo sapiens breast cancer 27829232 Circular RNAs and their associations with breast cancer subtypes. Nair AA, Niu N, Tang X, Thompson KJ, Wang L, Kocher JP, Subramanian S, Kalari KR. Oncotarget. 2016 expressed in MCF-7 RNA-seq, qRT-PCR, sanger sequencing MCF-7 circAFF1 circRNA homo sapiens AFF1 breast cancer 28739726 HIF1α-associated circDENND4C Promotes Proliferation of Breast Cancer Cells in Hypoxic Environment. Liang G, Liu Z, Tan L, Su AN, Jiang WG, Gong C. Anticancer Res. 2017 hypoxia-associated circRNAs in endothelial cells after hypoxia induction qRT-PCR MCF-7 and MDA-MB-231 circFOXJ3 circRNA homo sapiens FOXJ3 breast cancer 28739726 HIF1α-associated circDENND4C Promotes Proliferation of Breast Cancer Cells in Hypoxic Environment. Liang G, Liu Z, Tan L, Su AN, Jiang WG, Gong C. Anticancer Res. 2017 hypoxia-associated circRNAs in endothelial cells after hypoxia induction qRT-PCR MCF-7 and MDA-MB-231 circSRSF4 circRNA homo sapiens SRSF4 breast cancer 28739726 HIF1α-associated circDENND4C Promotes Proliferation of Breast Cancer Cells in Hypoxic Environment. Liang G, Liu Z, Tan L, Su AN, Jiang WG, Gong C. Anticancer Res. 2017 hypoxia-associated circRNAs in endothelial cells after hypoxia induction qRT-PCR MCF-7 and MDA-MB-231 circTHSD1 circRNA homo sapiens THSD1 breast cancer 28739726 HIF1α-associated circDENND4C Promotes Proliferation of Breast Cancer Cells in Hypoxic Environment. Liang G, Liu Z, Tan L, Su AN, Jiang WG, Gong C. Anticancer Res. 2017 hypoxia-associated circRNAs in endothelial cells after hypoxia induction qRT-PCR MCF-7 and MDA-MB-231 circZNF292 circRNA homo sapiens ZNF292 breast cancer 28739726 HIF1α-associated circDENND4C Promotes Proliferation of Breast Cancer Cells in Hypoxic Environment. Liang G, Liu Z, Tan L, Su AN, Jiang WG, Gong C. Anticancer Res. 2017 hypoxia-associated circRNAs in endothelial cells after hypoxia induction qRT-PCR MCF-7 and MDA-MB-231 circ-HIPK3 circRNA homo sapiens HIPK3 26138677 Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis. Li Y, Zheng Q, Bao C, Li S, Guo W, Zhao J, Chen D, Gu J, He X, Huang S. Cell Res. 2015 higher in cells than exosomes RNA-seq, qRT-PCR MHCC-LM3, HeLa, MCF-7, SMCC-7721, HCT-116, MGC-803, NCI-H1299 cells and cell-derived exosomes circ-MET circRNA homo sapiens MET 26138677 Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis. Li Y, Zheng Q, Bao C, Li S, Guo W, Zhao J, Chen D, Gu J, He X, Huang S. Cell Res. 2015 higher in cells than exosomes RNA-seq, qRT-PCR MHCC-LM3, HeLa, MCF-7, SMCC-7721, HCT-116, MGC-803, NCI-H1299 cells and cell-derived exosomes circ-CAMSAP1 circRNA homo sapiens CAMSAP1 26138677 Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis. Li Y, Zheng Q, Bao C, Li S, Guo W, Zhao J, Chen D, Gu J, He X, Huang S. Cell Res. 2015 lower in cells than exosomes RNA-seq, qRT-PCR MHCC-LM3, HeLa, MCF-7, SMCC-7721, HCT-116, MGC-803, NCI-H1299 cells and cell-derived exosomes circ-CDYL circRNA homo sapiens CDYL 26138677 Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis. Li Y, Zheng Q, Bao C, Li S, Guo W, Zhao J, Chen D, Gu J, He X, Huang S. Cell Res. 2015 lower in cells than exosomes RNA-seq, qRT-PCR MHCC-LM3, HeLa, MCF-7, SMCC-7721, HCT-116, MGC-803, NCI-H1299 cells and cell-derived exosomes circ-EZH2 circRNA homo sapiens EZH2 26138677 Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis. Li Y, Zheng Q, Bao C, Li S, Guo W, Zhao J, Chen D, Gu J, He X, Huang S. Cell Res. 2015 lower in cells than exosomes RNA-seq, qRT-PCR MHCC-LM3, HeLa, MCF-7, SMCC-7721, HCT-116, MGC-803, NCI-H1299 cells and cell-derived exosomes circ-FOXK2 circRNA homo sapiens FOXK2 26138677 Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis. Li Y, Zheng Q, Bao C, Li S, Guo W, Zhao J, Chen D, Gu J, He X, Huang S. Cell Res. 2015 lower in cells than exosomes RNA-seq, qRT-PCR MHCC-LM3, HeLa, MCF-7, SMCC-7721, HCT-116, MGC-803, NCI-H1299 cells and cell-derived exosomes circ-XPO1 circRNA homo sapiens XPO1 26138677 Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis. Li Y, Zheng Q, Bao C, Li S, Guo W, Zhao J, Chen D, Gu J, He X, Huang S. Cell Res. 2015 lower in cells than exosomes RNA-seq, qRT-PCR MHCC-LM3, HeLa, MCF-7, SMCC-7721, HCT-116, MGC-803, NCI-H1299 cells and cell-derived exosomes hsa_circRNA_050898 circRNA homo sapiens Moyamoya disease 28991692 Altered expression of circular RNAs in Moyamoya disease. Zhao M, Gao F, Zhang D, Wang S, Zhang Y, Wang R, Zhao J. J Neurol Sci. 2017 The expression levels of hsa_circRNA_050898 were analyzed by qRT-PCR in twelve MMD and matched control samples. The measured circRNA levels were concordant with those obtained by microarray, confirming the reliability of the data. microarray, qRT-PCR Moyamoya disease patients and controls hsa_circRNA_067209 circRNA homo sapiens Moyamoya disease 28991692 Altered expression of circular RNAs in Moyamoya disease. Zhao M, Gao F, Zhang D, Wang S, Zhang Y, Wang R, Zhao J. J Neurol Sci. 2017 The expression levels of hsa_circRNA_067209 were analyzed by qRT-PCR in twelve MMD and matched control samples. The measured circRNA levels were concordant with those obtained by microarray, confirming the reliability of the data. microarray, qRT-PCR Moyamoya disease patients and controls hsa_circRNA_100914 circRNA homo sapiens Moyamoya disease 28991692 Altered expression of circular RNAs in Moyamoya disease. Zhao M, Gao F, Zhang D, Wang S, Zhang Y, Wang R, Zhao J. J Neurol Sci. 2017 The expression levels of hsa_circRNA_100914 were analyzed by qRT-PCR in twelve MMD and matched control samples. The measured circRNA levels were concordant with those obtained by microarray, confirming the reliability of the data. microarray, qRT-PCR Moyamoya disease patients and controls hsa_circRNA_101720 circRNA homo sapiens Moyamoya disease 28991692 Altered expression of circular RNAs in Moyamoya disease. Zhao M, Gao F, Zhang D, Wang S, Zhang Y, Wang R, Zhao J. J Neurol Sci. 2017 The expression levels of hsa_circRNA_101720 were analyzed by qRT-PCR in twelve MMD and matched control samples. The measured circRNA levels were concordant with those obtained by microarray, confirming the reliability of the data. microarray, qRT-PCR Moyamoya disease patients and controls hsa_circRNA_103343 circRNA homo sapiens Moyamoya disease 28991692 Altered expression of circular RNAs in Moyamoya disease. Zhao M, Gao F, Zhang D, Wang S, Zhang Y, Wang R, Zhao J. J Neurol Sci. 2017 The expression levels of hsa_circRNA_103343 were analyzed by qRT-PCR in twelve MMD and matched control samples. The measured circRNA levels were concordant with those obtained by microarray, confirming the reliability of the data. microarray, qRT-PCR Moyamoya disease patients and controls circ_0005402 circRNA homo sapiens multiple sclerosis 28651352 Circular RNA profiling reveals that circular RNAs from ANXA2 can be used as new biomarkers for multiple sclerosis. Iparraguirre L, Muñoz-Culla M, Prada-Luengo I, Castillo-Triviño T, Olascoaga J, Otaegui D. Hum Mol Genet. 2017 Down-regulated in peripheral blood leucocytes from multiple sclerosis patients compared to healthy controls, could be used as biomarkers of the disease. microarray, qRT-PCR multiple sclerosis patients and healthy controls circ_0035560 circRNA homo sapiens multiple sclerosis 28651352 Circular RNA profiling reveals that circular RNAs from ANXA2 can be used as new biomarkers for multiple sclerosis. Iparraguirre L, Muñoz-Culla M, Prada-Luengo I, Castillo-Triviño T, Olascoaga J, Otaegui D. Hum Mol Genet. 2017 Down-regulated in peripheral blood leucocytes from multiple sclerosis patients compared to healthy controls, could be used as biomarkers of the disease. microarray, qRT-PCR multiple sclerosis patients and healthy controls cANRIL14-5 circRNA homo sapiens ANRIL 21151960 Expression of linear and novel circular forms of an INK4/ARF-associated non-coding RNA correlates with atherosclerosis risk. Burd CE, Jeck WR, Liu Y, Sanoff HK, Wang Z, Sharpless NE. PLoS Genet. 2010 These data provide evidence that ANRIL4-6 and 14-5 are predominantly contained within non-polyadenylated, circular (or lariat) ANRIL (cANRIL) transcripts. qRT-PCR normal and immortalized human fibroblasts (IMR90 and Hs68) cANRIL4-6 circRNA homo sapiens ANRIL 21151960 Expression of linear and novel circular forms of an INK4/ARF-associated non-coding RNA correlates with atherosclerosis risk. Burd CE, Jeck WR, Liu Y, Sanoff HK, Wang Z, Sharpless NE. PLoS Genet. 2010 These data provide evidence that ANRIL4-6 and 14-5 are predominantly contained within non-polyadenylated, circular (or lariat) ANRIL (cANRIL) transcripts. qRT-PCR normal and immortalized human fibroblasts (IMR90 and Hs68) circ_ADCY1 circRNA homo sapiens ADCY1 26873924 Circular RNA profile in gliomas revealed by identification tool UROBORUS. Song X, Zhang N, Han P, Moon BS, Lai RK, Wang K, Lu W. Nucleic Acids Res. 2016 For the 27 randomly selected circRNAs, we successfully amplified 24 circRNAs from total RNA samples or RNase R treated RNA samples, in which circular CORO1C (0.061 RPM, supported by 7 read counts), expressed at lower levels, was also validated, but not amplified any circRNAs in genomic DNA samples. qRT-PCR normal, oligodendroglioma or GBM tissue circ_BEND6 circRNA homo sapiens BEND6 26873924 Circular RNA profile in gliomas revealed by identification tool UROBORUS. Song X, Zhang N, Han P, Moon BS, Lai RK, Wang K, Lu W. Nucleic Acids Res. 2016 For the 27 randomly selected circRNAs, we successfully amplified 24 circRNAs from total RNA samples or RNase R treated RNA samples, in which circular CORO1C (0.061 RPM, supported by 7 read counts), expressed at lower levels, was also validated, but not amplified any circRNAs in genomic DNA samples. qRT-PCR normal, oligodendroglioma or GBM tissue circ_CEP192 circRNA homo sapiens CEP192 26873924 Circular RNA profile in gliomas revealed by identification tool UROBORUS. Song X, Zhang N, Han P, Moon BS, Lai RK, Wang K, Lu W. Nucleic Acids Res. 2016 For the 27 randomly selected circRNAs, we successfully amplified 24 circRNAs from total RNA samples or RNase R treated RNA samples, in which circular CORO1C (0.061 RPM, supported by 7 read counts), expressed at lower levels, was also validated, but not amplified any circRNAs in genomic DNA samples. qRT-PCR normal, oligodendroglioma or GBM tissue circ_CORO1C circRNA homo sapiens CORO1C 26873924 Circular RNA profile in gliomas revealed by identification tool UROBORUS. Song X, Zhang N, Han P, Moon BS, Lai RK, Wang K, Lu W. Nucleic Acids Res. 2016 For the 27 randomly selected circRNAs, we successfully amplified 24 circRNAs from total RNA samples or RNase R treated RNA samples, in which circular CORO1C (0.061 RPM, supported by 7 read counts), expressed at lower levels, was also validated, but not amplified any circRNAs in genomic DNA samples. qRT-PCR normal, oligodendroglioma or GBM tissue circ_CRKL circRNA homo sapiens CRKL 26873924 Circular RNA profile in gliomas revealed by identification tool UROBORUS. Song X, Zhang N, Han P, Moon BS, Lai RK, Wang K, Lu W. Nucleic Acids Res. 2016 For the 27 randomly selected circRNAs, we successfully amplified 24 circRNAs from total RNA samples or RNase R treated RNA samples, in which circular CORO1C (0.061 RPM, supported by 7 read counts), expressed at lower levels, was also validated, but not amplified any circRNAs in genomic DNA samples. qRT-PCR normal, oligodendroglioma or GBM tissue circ_EML5 circRNA homo sapiens EML5 26873924 Circular RNA profile in gliomas revealed by identification tool UROBORUS. Song X, Zhang N, Han P, Moon BS, Lai RK, Wang K, Lu W. Nucleic Acids Res. 2016 For the 27 randomly selected circRNAs, we successfully amplified 24 circRNAs from total RNA samples or RNase R treated RNA samples, in which circular CORO1C (0.061 RPM, supported by 7 read counts), expressed at lower levels, was also validated, but not amplified any circRNAs in genomic DNA samples. qRT-PCR normal, oligodendroglioma or GBM tissue circ_ETFA circRNA homo sapiens ETFA 26873924 Circular RNA profile in gliomas revealed by identification tool UROBORUS. Song X, Zhang N, Han P, Moon BS, Lai RK, Wang K, Lu W. Nucleic Acids Res. 2016 For the 27 randomly selected circRNAs, we successfully amplified 24 circRNAs from total RNA samples or RNase R treated RNA samples, in which circular CORO1C (0.061 RPM, supported by 7 read counts), expressed at lower levels, was also validated, but not amplified any circRNAs in genomic DNA samples. qRT-PCR normal, oligodendroglioma or GBM tissue circ_FKBP8 circRNA homo sapiens FKBP8 26873924 Circular RNA profile in gliomas revealed by identification tool UROBORUS. Song X, Zhang N, Han P, Moon BS, Lai RK, Wang K, Lu W. Nucleic Acids Res. 2016 For the 27 randomly selected circRNAs, we successfully amplified 24 circRNAs from total RNA samples or RNase R treated RNA samples, in which circular CORO1C (0.061 RPM, supported by 7 read counts), expressed at lower levels, was also validated, but not amplified any circRNAs in genomic DNA samples. qRT-PCR normal, oligodendroglioma or GBM tissue circ_MAN1A2 circRNA homo sapiens MAN1A2 26873924 Circular RNA profile in gliomas revealed by identification tool UROBORUS. Song X, Zhang N, Han P, Moon BS, Lai RK, Wang K, Lu W. Nucleic Acids Res. 2016 For the 27 randomly selected circRNAs, we successfully amplified 24 circRNAs from total RNA samples or RNase R treated RNA samples, in which circular CORO1C (0.061 RPM, supported by 7 read counts), expressed at lower levels, was also validated, but not amplified any circRNAs in genomic DNA samples. qRT-PCR normal, oligodendroglioma or GBM tissue circ_MCTP1 circRNA homo sapiens MCTP1 26873924 Circular RNA profile in gliomas revealed by identification tool UROBORUS. Song X, Zhang N, Han P, Moon BS, Lai RK, Wang K, Lu W. Nucleic Acids Res. 2016 For the 27 randomly selected circRNAs, we successfully amplified 24 circRNAs from total RNA samples or RNase R treated RNA samples, in which circular CORO1C (0.061 RPM, supported by 7 read counts), expressed at lower levels, was also validated, but not amplified any circRNAs in genomic DNA samples. qRT-PCR normal, oligodendroglioma or GBM tissue circ_MED12L circRNA homo sapiens MED12L 26873924 Circular RNA profile in gliomas revealed by identification tool UROBORUS. Song X, Zhang N, Han P, Moon BS, Lai RK, Wang K, Lu W. Nucleic Acids Res. 2016 For the 27 randomly selected circRNAs, we successfully amplified 24 circRNAs from total RNA samples or RNase R treated RNA samples, in which circular CORO1C (0.061 RPM, supported by 7 read counts), expressed at lower levels, was also validated, but not amplified any circRNAs in genomic DNA samples. qRT-PCR normal, oligodendroglioma or GBM tissue circ_R3HDM1 circRNA homo sapiens R3HDM1 26873924 Circular RNA profile in gliomas revealed by identification tool UROBORUS. Song X, Zhang N, Han P, Moon BS, Lai RK, Wang K, Lu W. Nucleic Acids Res. 2016 For the 27 randomly selected circRNAs, we successfully amplified 24 circRNAs from total RNA samples or RNase R treated RNA samples, in which circular CORO1C (0.061 RPM, supported by 7 read counts), expressed at lower levels, was also validated, but not amplified any circRNAs in genomic DNA samples. qRT-PCR normal, oligodendroglioma or GBM tissue circ_RIMS1 circRNA homo sapiens RIMS1 26873924 Circular RNA profile in gliomas revealed by identification tool UROBORUS. Song X, Zhang N, Han P, Moon BS, Lai RK, Wang K, Lu W. Nucleic Acids Res. 2016 For the 27 randomly selected circRNAs, we successfully amplified 24 circRNAs from total RNA samples or RNase R treated RNA samples, in which circular CORO1C (0.061 RPM, supported by 7 read counts), expressed at lower levels, was also validated, but not amplified any circRNAs in genomic DNA samples. qRT-PCR normal, oligodendroglioma or GBM tissue circ_RNF10 circRNA homo sapiens RNF10 26873924 Circular RNA profile in gliomas revealed by identification tool UROBORUS. Song X, Zhang N, Han P, Moon BS, Lai RK, Wang K, Lu W. Nucleic Acids Res. 2016 For the 27 randomly selected circRNAs, we successfully amplified 24 circRNAs from total RNA samples or RNase R treated RNA samples, in which circular CORO1C (0.061 RPM, supported by 7 read counts), expressed at lower levels, was also validated, but not amplified any circRNAs in genomic DNA samples. qRT-PCR normal, oligodendroglioma or GBM tissue circ_SAFB2 circRNA homo sapiens SAFB2 26873924 Circular RNA profile in gliomas revealed by identification tool UROBORUS. Song X, Zhang N, Han P, Moon BS, Lai RK, Wang K, Lu W. Nucleic Acids Res. 2016 For the 27 randomly selected circRNAs, we successfully amplified 24 circRNAs from total RNA samples or RNase R treated RNA samples, in which circular CORO1C (0.061 RPM, supported by 7 read counts), expressed at lower levels, was also validated, but not amplified any circRNAs in genomic DNA samples. qRT-PCR normal, oligodendroglioma or GBM tissue circ_SLC8A1 circRNA homo sapiens SLC8A1 26873924 Circular RNA profile in gliomas revealed by identification tool UROBORUS. Song X, Zhang N, Han P, Moon BS, Lai RK, Wang K, Lu W. Nucleic Acids Res. 2016 For the 27 randomly selected circRNAs, we successfully amplified 24 circRNAs from total RNA samples or RNase R treated RNA samples, in which circular CORO1C (0.061 RPM, supported by 7 read counts), expressed at lower levels, was also validated, but not amplified any circRNAs in genomic DNA samples. qRT-PCR normal, oligodendroglioma or GBM tissue circ_STXBP5L circRNA homo sapiens STXBP5L 26873924 Circular RNA profile in gliomas revealed by identification tool UROBORUS. Song X, Zhang N, Han P, Moon BS, Lai RK, Wang K, Lu W. Nucleic Acids Res. 2016 For the 27 randomly selected circRNAs, we successfully amplified 24 circRNAs from total RNA samples or RNase R treated RNA samples, in which circular CORO1C (0.061 RPM, supported by 7 read counts), expressed at lower levels, was also validated, but not amplified any circRNAs in genomic DNA samples. qRT-PCR normal, oligodendroglioma or GBM tissue circ_UNC79 circRNA homo sapiens UNC79 26873924 Circular RNA profile in gliomas revealed by identification tool UROBORUS. Song X, Zhang N, Han P, Moon BS, Lai RK, Wang K, Lu W. Nucleic Acids Res. 2016 For the 27 randomly selected circRNAs, we successfully amplified 24 circRNAs from total RNA samples or RNase R treated RNA samples, in which circular CORO1C (0.061 RPM, supported by 7 read counts), expressed at lower levels, was also validated, but not amplified any circRNAs in genomic DNA samples. qRT-PCR normal, oligodendroglioma or GBM tissue circ_VCAN circRNA homo sapiens VCAN 26873924 Circular RNA profile in gliomas revealed by identification tool UROBORUS. Song X, Zhang N, Han P, Moon BS, Lai RK, Wang K, Lu W. Nucleic Acids Res. 2016 For the 27 randomly selected circRNAs, we successfully amplified 24 circRNAs from total RNA samples or RNase R treated RNA samples, in which circular CORO1C (0.061 RPM, supported by 7 read counts), expressed at lower levels, was also validated, but not amplified any circRNAs in genomic DNA samples. qRT-PCR normal, oligodendroglioma or GBM tissue circ_ZNF148 circRNA homo sapiens ZNF148 26873924 Circular RNA profile in gliomas revealed by identification tool UROBORUS. Song X, Zhang N, Han P, Moon BS, Lai RK, Wang K, Lu W. Nucleic Acids Res. 2016 For the 27 randomly selected circRNAs, we successfully amplified 24 circRNAs from total RNA samples or RNase R treated RNA samples, in which circular CORO1C (0.061 RPM, supported by 7 read counts), expressed at lower levels, was also validated, but not amplified any circRNAs in genomic DNA samples. qRT-PCR normal, oligodendroglioma or GBM tissue circ_HIPK3 circRNA homo sapiens HIPK3 26873924 Circular RNA profile in gliomas revealed by identification tool UROBORUS. Song X, Zhang N, Han P, Moon BS, Lai RK, Wang K, Lu W. Nucleic Acids Res. 2016 For the 27 randomly selected circRNAs, we successfully amplified 24 circRNAs from total RNA samples or RNase R treated RNA samples, in which circular CORO1C (0.061 RPM, supported by 7 read counts), expressed at lower levels, was also validated, but not amplified any circRNAs in genomic DNA samples. qRT-PCR normal, oligodendroglioma or GBM tissue circ_KCNN2 circRNA homo sapiens KCNN2 26873924 Circular RNA profile in gliomas revealed by identification tool UROBORUS. Song X, Zhang N, Han P, Moon BS, Lai RK, Wang K, Lu W. Nucleic Acids Res. 2016 For the 27 randomly selected circRNAs, we successfully amplified 24 circRNAs from total RNA samples or RNase R treated RNA samples, in which circular CORO1C (0.061 RPM, supported by 7 read counts), expressed at lower levels, was also validated, but not amplified any circRNAs in genomic DNA samples. qRT-PCR normal, oligodendroglioma or GBM tissue circ_SMARCA5 circRNA homo sapiens SMARCA5 26873924 Circular RNA profile in gliomas revealed by identification tool UROBORUS. Song X, Zhang N, Han P, Moon BS, Lai RK, Wang K, Lu W. Nucleic Acids Res. 2016 For the 27 randomly selected circRNAs, we successfully amplified 24 circRNAs from total RNA samples or RNase R treated RNA samples, in which circular CORO1C (0.061 RPM, supported by 7 read counts), expressed at lower levels, was also validated, but not amplified any circRNAs in genomic DNA samples. qRT-PCR normal, oligodendroglioma or GBM tissue circRNA_100086 circRNA homo sapiens Cartilage Degradation 26931159 Circular RNA Related to the Chondrocyte ECM Regulates MMP13 Expression by Functioning as a MiR-136 Sponge in Human Cartilage Degradation. Liu Q, Zhang X, Hu X, Dai L, Fu X, Zhang J, Ao Y. Sci Rep. 2016 overexpressed in OA. qRT-PCR osteoarthritis circRNA_101178 circRNA homo sapiens Cartilage Degradation 26931159 Circular RNA Related to the Chondrocyte ECM Regulates MMP13 Expression by Functioning as a MiR-136 Sponge in Human Cartilage Degradation. Liu Q, Zhang X, Hu X, Dai L, Fu X, Zhang J, Ao Y. Sci Rep. 2016 overexpressed in OA. qRT-PCR osteoarthritis circRNA_101914 circRNA homo sapiens Cartilage Degradation 26931159 Circular RNA Related to the Chondrocyte ECM Regulates MMP13 Expression by Functioning as a MiR-136 Sponge in Human Cartilage Degradation. Liu Q, Zhang X, Hu X, Dai L, Fu X, Zhang J, Ao Y. Sci Rep. 2016 overexpressed in OA. qRT-PCR osteoarthritis hsa_circRNA_100258 circRNA homo sapiens osteosarcoma 28957794 Microarray Expression Profile and Functional Analysis of Circular RNAs in Osteosarcoma. Liu W, Zhang J, Zou C, Xie X, Wang Y, Wang B, Zhao Z, Tu J, Wang X, Li H, Shen J, Yin J. Cell Physiol Biochem. 2017 downregulated microarray, qRT-PCR osteosarcoma tumor tissues and matched adjacent normal tissues, ZOS, ZOS-M, hFOB1.19, U2OS, MG63, HOS and 143B hsa_circRNA_102678 circRNA homo sapiens osteosarcoma 28957794 Microarray Expression Profile and Functional Analysis of Circular RNAs in Osteosarcoma. Liu W, Zhang J, Zou C, Xie X, Wang Y, Wang B, Zhao Z, Tu J, Wang X, Li H, Shen J, Yin J. Cell Physiol Biochem. 2017 downregulated microarray, qRT-PCR osteosarcoma tumor tissues and matched adjacent normal tissues, ZOS, ZOS-M, hFOB1.19, U2OS, MG63, HOS and 143B hsa_circRNA_103110 circRNA homo sapiens osteosarcoma 28957794 Microarray Expression Profile and Functional Analysis of Circular RNAs in Osteosarcoma. Liu W, Zhang J, Zou C, Xie X, Wang Y, Wang B, Zhao Z, Tu J, Wang X, Li H, Shen J, Yin J. Cell Physiol Biochem. 2017 downregulated microarray, qRT-PCR osteosarcoma tumor tissues and matched adjacent normal tissues, ZOS, ZOS-M, hFOB1.19, U2OS, MG63, HOS and 143B hsa_circRNA_104692 circRNA homo sapiens osteosarcoma 28957794 Microarray Expression Profile and Functional Analysis of Circular RNAs in Osteosarcoma. Liu W, Zhang J, Zou C, Xie X, Wang Y, Wang B, Zhao Z, Tu J, Wang X, Li H, Shen J, Yin J. Cell Physiol Biochem. 2017 downregulated microarray, qRT-PCR osteosarcoma tumor tissues and matched adjacent normal tissues, ZOS, ZOS-M, hFOB1.19, U2OS, MG63, HOS and 143B hsa_circRNA_104892 circRNA homo sapiens osteosarcoma 28957794 Microarray Expression Profile and Functional Analysis of Circular RNAs in Osteosarcoma. Liu W, Zhang J, Zou C, Xie X, Wang Y, Wang B, Zhao Z, Tu J, Wang X, Li H, Shen J, Yin J. Cell Physiol Biochem. 2017 downregulated microarray, qRT-PCR osteosarcoma tumor tissues and matched adjacent normal tissues, ZOS, ZOS-M, hFOB1.19, U2OS, MG63, HOS and 143B hsa_circRNA_104980 circRNA homo sapiens osteosarcoma 28957794 Microarray Expression Profile and Functional Analysis of Circular RNAs in Osteosarcoma. Liu W, Zhang J, Zou C, Xie X, Wang Y, Wang B, Zhao Z, Tu J, Wang X, Li H, Shen J, Yin J. Cell Physiol Biochem. 2017 downregulated microarray, qRT-PCR osteosarcoma tumor tissues and matched adjacent normal tissues, ZOS, ZOS-M, hFOB1.19, U2OS, MG63, HOS and 143B hsa_circRNA_100241 circRNA homo sapiens osteosarcoma 28957794 Microarray Expression Profile and Functional Analysis of Circular RNAs in Osteosarcoma. Liu W, Zhang J, Zou C, Xie X, Wang Y, Wang B, Zhao Z, Tu J, Wang X, Li H, Shen J, Yin J. Cell Physiol Biochem. 2017 upregulated microarray, qRT-PCR osteosarcoma tumor tissues and matched adjacent normal tissues, ZOS, ZOS-M, hFOB1.19, U2OS, MG63, HOS and 143B hsa_circRNA_101113 circRNA homo sapiens osteosarcoma 28957794 Microarray Expression Profile and Functional Analysis of Circular RNAs in Osteosarcoma. Liu W, Zhang J, Zou C, Xie X, Wang Y, Wang B, Zhao Z, Tu J, Wang X, Li H, Shen J, Yin J. Cell Physiol Biochem. 2017 upregulated microarray, qRT-PCR osteosarcoma tumor tissues and matched adjacent normal tissues, ZOS, ZOS-M, hFOB1.19, U2OS, MG63, HOS and 143B hsa_circRNA_102049 circRNA homo sapiens osteosarcoma 28957794 Microarray Expression Profile and Functional Analysis of Circular RNAs in Osteosarcoma. Liu W, Zhang J, Zou C, Xie X, Wang Y, Wang B, Zhao Z, Tu J, Wang X, Li H, Shen J, Yin J. Cell Physiol Biochem. 2017 upregulated microarray, qRT-PCR osteosarcoma tumor tissues and matched adjacent normal tissues, ZOS, ZOS-M, hFOB1.19, U2OS, MG63, HOS and 143B hsa_circRNA_102485 circRNA homo sapiens osteosarcoma 28957794 Microarray Expression Profile and Functional Analysis of Circular RNAs in Osteosarcoma. Liu W, Zhang J, Zou C, Xie X, Wang Y, Wang B, Zhao Z, Tu J, Wang X, Li H, Shen J, Yin J. Cell Physiol Biochem. 2017 upregulated microarray, qRT-PCR osteosarcoma tumor tissues and matched adjacent normal tissues, ZOS, ZOS-M, hFOB1.19, U2OS, MG63, HOS and 143B hsa_circRNA_103309 circRNA homo sapiens osteosarcoma 28957794 Microarray Expression Profile and Functional Analysis of Circular RNAs in Osteosarcoma. Liu W, Zhang J, Zou C, Xie X, Wang Y, Wang B, Zhao Z, Tu J, Wang X, Li H, Shen J, Yin J. Cell Physiol Biochem. 2017 upregulated microarray, qRT-PCR osteosarcoma tumor tissues and matched adjacent normal tissues, ZOS, ZOS-M, hFOB1.19, U2OS, MG63, HOS and 143B hsa_circRNA_103801 circRNA homo sapiens osteosarcoma 28957794 Microarray Expression Profile and Functional Analysis of Circular RNAs in Osteosarcoma. Liu W, Zhang J, Zou C, Xie X, Wang Y, Wang B, Zhao Z, Tu J, Wang X, Li H, Shen J, Yin J. Cell Physiol Biochem. 2017 upregulated microarray, qRT-PCR osteosarcoma tumor tissues and matched adjacent normal tissues, ZOS, ZOS-M, hFOB1.19, U2OS, MG63, HOS and 143B circ_0003570 circRNA homo sapiens Ovarian Endometriosis 29490568 The Relationship of Circular RNAs With Ovarian Endometriosis. Xu X, Jia SZ, Dai Y, Zhang JJ, Li X, Shi J, Leng J, Lang J. Reprod Sci. 2018 Down-regulated in Ovarian ectopic endometrium (EcE) samples compared to paired eutopic endometrium (EuE) microarray, qRT-PCR Ovarian ectopic endometrium (EcE) samples, paired eutopic endometrium (EuE) circ_0002198 circRNA homo sapiens Ovarian Endometriosis 29490568 The Relationship of Circular RNAs With Ovarian Endometriosis. Xu X, Jia SZ, Dai Y, Zhang JJ, Li X, Shi J, Leng J, Lang J. Reprod Sci. 2018 up-regulated in Ovarian ectopic endometrium (EcE) samples compared to paired eutopic endometrium (EuE) microarray, qRT-PCR Ovarian ectopic endometrium (EcE) samples, paired eutopic endometrium (EuE) circ_0004712 circRNA homo sapiens Ovarian Endometriosis 29490568 The Relationship of Circular RNAs With Ovarian Endometriosis. Xu X, Jia SZ, Dai Y, Zhang JJ, Li X, Shi J, Leng J, Lang J. Reprod Sci. 2018 up-regulated in Ovarian ectopic endometrium (EcE) samples compared to paired eutopic endometrium (EuE) microarray, qRT-PCR Ovarian ectopic endometrium (EcE) samples, paired eutopic endometrium (EuE) circ_0008951 circRNA homo sapiens Ovarian Endometriosis 29490568 The Relationship of Circular RNAs With Ovarian Endometriosis. Xu X, Jia SZ, Dai Y, Zhang JJ, Li X, Shi J, Leng J, Lang J. Reprod Sci. 2018 up-regulated in Ovarian ectopic endometrium (EcE) samples compared to paired eutopic endometrium (EuE) microarray, qRT-PCR Ovarian ectopic endometrium (EcE) samples, paired eutopic endometrium (EuE) circ_0017248 circRNA homo sapiens Ovarian Endometriosis 29490568 The Relationship of Circular RNAs With Ovarian Endometriosis. Xu X, Jia SZ, Dai Y, Zhang JJ, Li X, Shi J, Leng J, Lang J. Reprod Sci. 2018 up-regulated in Ovarian ectopic endometrium (EcE) samples compared to paired eutopic endometrium (EuE) microarray, qRT-PCR Ovarian ectopic endometrium (EcE) samples, paired eutopic endometrium (EuE) circ_ARHGAP5 circRNA homo sapiens ARHGAP5 ovarian cancer 27119352 Altered expression pattern of circular RNAs in primary and metastatic sites of epithelial ovarian carcinoma. Ahmed I, Karedath T, Andrews SS, Al-Azwani IK, Mohamoud YA, Querleu D, Rafii A, Malek JA. Oncotarget. 2016 expressed in ovarian cancer cells RNA-seq,RT-PCR OVCAR3 and SKOV3 circ_PTP4A2 circRNA homo sapiens PTP4A2 ovarian cancer 27119352 Altered expression pattern of circular RNAs in primary and metastatic sites of epithelial ovarian carcinoma. Ahmed I, Karedath T, Andrews SS, Al-Azwani IK, Mohamoud YA, Querleu D, Rafii A, Malek JA. Oncotarget. 2016 expressed in ovarian cancer cells RNA-seq,RT-PCR OVCAR3 and SKOV3 circ_RANBP9 circRNA homo sapiens RANBP9 ovarian cancer 27119352 Altered expression pattern of circular RNAs in primary and metastatic sites of epithelial ovarian carcinoma. Ahmed I, Karedath T, Andrews SS, Al-Azwani IK, Mohamoud YA, Querleu D, Rafii A, Malek JA. Oncotarget. 2016 expressed in ovarian cancer cells RNA-seq,RT-PCR OVCAR3 and SKOV3 circ_SPECC1 circRNA homo sapiens SPECC1 ovarian cancer 27119352 Altered expression pattern of circular RNAs in primary and metastatic sites of epithelial ovarian carcinoma. Ahmed I, Karedath T, Andrews SS, Al-Azwani IK, Mohamoud YA, Querleu D, Rafii A, Malek JA. Oncotarget. 2016 expressed in ovarian cancer cells RNA-seq,RT-PCR OVCAR3 and SKOV3 circ_TRIP12 circRNA homo sapiens TRIP12 ovarian cancer 27119352 Altered expression pattern of circular RNAs in primary and metastatic sites of epithelial ovarian carcinoma. Ahmed I, Karedath T, Andrews SS, Al-Azwani IK, Mohamoud YA, Querleu D, Rafii A, Malek JA. Oncotarget. 2016 expressed in ovarian cancer cells RNA-seq,RT-PCR OVCAR3 and SKOV3 circ_NFATC3 circRNA homo sapiens NFATC3 ovarian cancer 27119352 Altered expression pattern of circular RNAs in primary and metastatic sites of epithelial ovarian carcinoma. Ahmed I, Karedath T, Andrews SS, Al-Azwani IK, Mohamoud YA, Querleu D, Rafii A, Malek JA. Oncotarget. 2016 expressed in ovarian cancer cells RNA-seq,RT-PCR, sanger sequencing OVCAR3 and SKOV3 circBMPR2 circRNA homo sapiens BMPR2 27068474 The Biogenesis of Nascent Circular RNAs. Zhang Y, Xue W, Li X, Zhang J, Chen S, Zhang JL, Yang L, Chen LL. Cell Rep. 2016 could be detected as early as with 120 min of 4sU labeling and also found with 4 and 16 hr of 4sU labeling qRT-PCR PA1 circCAMSAP1 circRNA homo sapiens CAMSAP1 27068474 The Biogenesis of Nascent Circular RNAs. Zhang Y, Xue W, Li X, Zhang J, Chen S, Zhang JL, Yang L, Chen LL. Cell Rep. 2016 could be detected as early as with 120 min of 4sU labeling and also found with 4 and 16 hr of 4sU labeling qRT-PCR PA1 circCDR1as circRNA homo sapiens CDR1 27068474 The Biogenesis of Nascent Circular RNAs. Zhang Y, Xue W, Li X, Zhang J, Chen S, Zhang JL, Yang L, Chen LL. Cell Rep. 2016 could be detected as early as with 120 min of 4sU labeling and also found with 4 and 16 hr of 4sU labeling qRT-PCR PA1 circPHC3 circRNA homo sapiens PHC3 27068474 The Biogenesis of Nascent Circular RNAs. Zhang Y, Xue W, Li X, Zhang J, Chen S, Zhang JL, Yang L, Chen LL. Cell Rep. 2016 could be detected as early as with 120 min of 4sU labeling and also found with 4 and 16 hr of 4sU labeling qRT-PCR PA1 circSPECC1 circRNA homo sapiens SPECC1 27068474 The Biogenesis of Nascent Circular RNAs. Zhang Y, Xue W, Li X, Zhang J, Chen S, Zhang JL, Yang L, Chen LL. Cell Rep. 2016 could be detected as early as with 120 min of 4sU labeling and also found with 4 and 16 hr of 4sU labeling qRT-PCR PA1 circTNFRSF21 circRNA homo sapiens TNFRSF21 27068474 The Biogenesis of Nascent Circular RNAs. Zhang Y, Xue W, Li X, Zhang J, Chen S, Zhang JL, Yang L, Chen LL. Cell Rep. 2016 could be detected as early as with 120 min of 4sU labeling and also found with 4 and 16 hr of 4sU labeling qRT-PCR PA1 circZNF148 circRNA homo sapiens ZNF148 27068474 The Biogenesis of Nascent Circular RNAs. Zhang Y, Xue W, Li X, Zhang J, Chen S, Zhang JL, Yang L, Chen LL. Cell Rep. 2016 could be detected as early as with 120 min of 4sU labeling and also found with 4 and 16 hr of 4sU labeling qRT-PCR PA1 circ_chr19:3660938-3662045 circRNA homo sapiens 27365365 Diverse alternative back-splicing and alternative splicing landscape of circular RNAs. Zhang XO, Dong R, Zhang Y, Zhang JL, Luo Z, Zhang J, Chen LL, Yang L. Genome Res. 2016 circRNA-predominant cassette exons in PA1 cells RT-PCR, sanger sequencing PA1 circ_chr2:61749735-61753693 circRNA homo sapiens 27365365 Diverse alternative back-splicing and alternative splicing landscape of circular RNAs. Zhang XO, Dong R, Zhang Y, Zhang JL, Luo Z, Zhang J, Chen LL, Yang L. Genome Res. 2016 circRNA-predominant cassette exons in PA1 cells RT-PCR, sanger sequencing PA1 circ_chr8:30335250-30336946 circRNA homo sapiens 27365365 Diverse alternative back-splicing and alternative splicing landscape of circular RNAs. Zhang XO, Dong R, Zhang Y, Zhang JL, Luo Z, Zhang J, Chen LL, Yang L. Genome Res. 2016 circRNA-predominant cassette exons in PA1 cells RT-PCR, sanger sequencing PA1 circ_chr8:62593446-62596821 circRNA homo sapiens 27365365 Diverse alternative back-splicing and alternative splicing landscape of circular RNAs. Zhang XO, Dong R, Zhang Y, Zhang JL, Luo Z, Zhang J, Chen LL, Yang L. Genome Res. 2016 circRNA-predominant cassette exons in PA1 cells RT-PCR, sanger sequencing PA1 circ_chr9:134311996-134314470 circRNA homo sapiens 27365365 Diverse alternative back-splicing and alternative splicing landscape of circular RNAs. Zhang XO, Dong R, Zhang Y, Zhang JL, Luo Z, Zhang J, Chen LL, Yang L. Genome Res. 2016 circRNA-predominant cassette exons in PA1 cells RT-PCR, sanger sequencing PA1 circ_chrX:24190724-24197982 circRNA homo sapiens 27365365 Diverse alternative back-splicing and alternative splicing landscape of circular RNAs. Zhang XO, Dong R, Zhang Y, Zhang JL, Luo Z, Zhang J, Chen LL, Yang L. Genome Res. 2016 circRNA-predominant cassette exons in PA1 cells RT-PCR, sanger sequencing PA1 circPOLR2A circRNA homo sapiens POLR2A 28625552 Coordinated circRNA Biogenesis and Function with NF90/NF110 in Viral Infection. Li X, Liu CX, Xue W, Zhang Y, Jiang S, Yin QF, Wei J, Yao RW, Yang L, Chen LL. Mol Cell. 2017 Such a positive regulation of NF90/NF110 on circRNA back-splicing was also confirmed by northern blotting (NB) with one abundant circRNA, circPOLR2A. northern blots PA1, HeLa, HEK293 circRBM33 circRNA homo sapiens RBM33 28625552 Coordinated circRNA Biogenesis and Function with NF90/NF110 in Viral Infection. Li X, Liu CX, Xue W, Zhang Y, Jiang S, Yin QF, Wei J, Yao RW, Yang L, Chen LL. Mol Cell. 2017 In agreement with the view that NF90/NF110 have a similar role in regulating back-splicing for some circRNAs, re-introduction of WT Flag-NF110, but not its truncations, into NF90 KD cells rescued the expression of circPOLR2A and circDHX34, but not circRBM33. qRT-PCR PA1, HeLa, HEK293 circDHX34 circRNA homo sapiens DHX34 28625552 Coordinated circRNA Biogenesis and Function with NF90/NF110 in Viral Infection. Li X, Liu CX, Xue W, Zhang Y, Jiang S, Yin QF, Wei J, Yao RW, Yang L, Chen LL. Mol Cell. 2017 while the expression of the DHX34 gene remained largely unchanged, circDHX34 was reduced 2-fold upon the depletion of NF90 or NF110. qRT-PCR PA1, HeLa, HEK293 circGPBP1 circRNA homo sapiens GPBP1 gastric cancer 27986464 Circular RNA profile identifies circPVT1 as a proliferative factor and prognostic marker in gastric cancer. Chen J, Li Y, Zheng Q, Bao C, He J, Chen B, Lyu D, Zheng B, Xu Y, Long Z, Zhou Y, Zhu H, Wang Y, He X, Shi Y, Huang S. Cancer Lett. 2017 down RNA-seq, qRT-PCR paired cancer specimens and adjacent normal tissues circKLHDC10 circRNA homo sapiens KLHDC10 gastric cancer 27986464 Circular RNA profile identifies circPVT1 as a proliferative factor and prognostic marker in gastric cancer. Chen J, Li Y, Zheng Q, Bao C, He J, Chen B, Lyu D, Zheng B, Xu Y, Long Z, Zhou Y, Zhu H, Wang Y, He X, Shi Y, Huang S. Cancer Lett. 2017 down RNA-seq, qRT-PCR paired cancer specimens and adjacent normal tissues circNRIP1 circRNA homo sapiens NRIP1 gastric cancer 27986464 Circular RNA profile identifies circPVT1 as a proliferative factor and prognostic marker in gastric cancer. Chen J, Li Y, Zheng Q, Bao C, He J, Chen B, Lyu D, Zheng B, Xu Y, Long Z, Zhou Y, Zhu H, Wang Y, He X, Shi Y, Huang S. Cancer Lett. 2017 up RNA-seq, qRT-PCR paired cancer specimens and adjacent normal tissues circOSBPL circRNA homo sapiens OSBPL gastric cancer 27986464 Circular RNA profile identifies circPVT1 as a proliferative factor and prognostic marker in gastric cancer. Chen J, Li Y, Zheng Q, Bao C, He J, Chen B, Lyu D, Zheng B, Xu Y, Long Z, Zhou Y, Zhu H, Wang Y, He X, Shi Y, Huang S. Cancer Lett. 2017 up RNA-seq, qRT-PCR paired cancer specimens and adjacent normal tissues Circ-104916 circRNA homo sapiens gastric cancer 28761361 Circ-104916 is downregulated in gastric cancer and suppresses migration and invasion of gastric cancer cells. Li J, Zhen L, Zhang Y, Zhao L, Liu H, Cai D, Chen H, Yu J, Qi X, Li G. Onco Targets Ther. 2017 The expression of circ-104916 is downregulated in GC tissues and cell lines. qRT-PCR paired cancer specimens and adjacent normal tissues, AGS, MKN-28, NCI-N87, MKN-45, GES-1 A lower expression of circ-104916 appeared in deeper invasion depth, higher tumor stage and more frequent lymphatic metastasis patients. Overexpression of circ-104916 effectively inhibited the proliferation, migration and invasion abilities of GC cells in vitro. gain of function BGC823, MGC803 hsa_circRNA_0018917 circRNA homo sapiens osteosarcoma 29415187 Microarray is an efficient tool for circRNA profiling. Li S, Teng S, Xu J, Su G, Zhang Y, Zhao J, Zhang S, Wang H, Qin W, Lu ZJ, Guo Y, Zhu Q, Wang D. Brief Bioinform. 2018 down microarray, qRT-PCR paired cervical tumor and normal tissue hsa_circRNA_0069272 circRNA homo sapiens osteosarcoma 29415187 Microarray is an efficient tool for circRNA profiling. Li S, Teng S, Xu J, Su G, Zhang Y, Zhao J, Zhang S, Wang H, Qin W, Lu ZJ, Guo Y, Zhu Q, Wang D. Brief Bioinform. 2018 down microarray, qRT-PCR paired cervical tumor and normal tissue hsa_circRNA_0070157 circRNA homo sapiens osteosarcoma 29415187 Microarray is an efficient tool for circRNA profiling. Li S, Teng S, Xu J, Su G, Zhang Y, Zhao J, Zhang S, Wang H, Qin W, Lu ZJ, Guo Y, Zhu Q, Wang D. Brief Bioinform. 2018 down microarray, qRT-PCR paired cervical tumor and normal tissue hsa_circRNA_0079474 circRNA homo sapiens osteosarcoma 29415187 Microarray is an efficient tool for circRNA profiling. Li S, Teng S, Xu J, Su G, Zhang Y, Zhao J, Zhang S, Wang H, Qin W, Lu ZJ, Guo Y, Zhu Q, Wang D. Brief Bioinform. 2018 down microarray, qRT-PCR paired cervical tumor and normal tissue hsa_circRNA_0013058 circRNA homo sapiens osteosarcoma 29415187 Microarray is an efficient tool for circRNA profiling. Li S, Teng S, Xu J, Su G, Zhang Y, Zhao J, Zhang S, Wang H, Qin W, Lu ZJ, Guo Y, Zhu Q, Wang D. Brief Bioinform. 2018 up microarray, qRT-PCR paired cervical tumor and normal tissue hsa_circRNA_0016103 circRNA homo sapiens osteosarcoma 29415187 Microarray is an efficient tool for circRNA profiling. Li S, Teng S, Xu J, Su G, Zhang Y, Zhao J, Zhang S, Wang H, Qin W, Lu ZJ, Guo Y, Zhu Q, Wang D. Brief Bioinform. 2018 up microarray, qRT-PCR paired cervical tumor and normal tissue hsa_circRNA_0017674 circRNA homo sapiens osteosarcoma 29415187 Microarray is an efficient tool for circRNA profiling. Li S, Teng S, Xu J, Su G, Zhang Y, Zhao J, Zhang S, Wang H, Qin W, Lu ZJ, Guo Y, Zhu Q, Wang D. Brief Bioinform. 2018 up microarray, qRT-PCR paired cervical tumor and normal tissue hsa_circRNA_0022812 circRNA homo sapiens osteosarcoma 29415187 Microarray is an efficient tool for circRNA profiling. Li S, Teng S, Xu J, Su G, Zhang Y, Zhao J, Zhang S, Wang H, Qin W, Lu ZJ, Guo Y, Zhu Q, Wang D. Brief Bioinform. 2018 up microarray, qRT-PCR paired cervical tumor and normal tissue hsa_circRNA_0026919 circRNA homo sapiens osteosarcoma 29415187 Microarray is an efficient tool for circRNA profiling. Li S, Teng S, Xu J, Su G, Zhang Y, Zhao J, Zhang S, Wang H, Qin W, Lu ZJ, Guo Y, Zhu Q, Wang D. Brief Bioinform. 2018 up microarray, qRT-PCR paired cervical tumor and normal tissue hsa_circRNA_0041427 circRNA homo sapiens osteosarcoma 29415187 Microarray is an efficient tool for circRNA profiling. Li S, Teng S, Xu J, Su G, Zhang Y, Zhao J, Zhang S, Wang H, Qin W, Lu ZJ, Guo Y, Zhu Q, Wang D. Brief Bioinform. 2018 up microarray, qRT-PCR paired cervical tumor and normal tissue hsa_circRNA_0074590 circRNA homo sapiens osteosarcoma 29415187 Microarray is an efficient tool for circRNA profiling. Li S, Teng S, Xu J, Su G, Zhang Y, Zhao J, Zhang S, Wang H, Qin W, Lu ZJ, Guo Y, Zhu Q, Wang D. Brief Bioinform. 2018 up microarray, qRT-PCR paired cervical tumor and normal tissue hsa_circRNA_0084975 circRNA homo sapiens osteosarcoma 29415187 Microarray is an efficient tool for circRNA profiling. Li S, Teng S, Xu J, Su G, Zhang Y, Zhao J, Zhang S, Wang H, Qin W, Lu ZJ, Guo Y, Zhu Q, Wang D. Brief Bioinform. 2018 up microarray, qRT-PCR paired cervical tumor and normal tissue hsa_circRNA_0085841 circRNA homo sapiens osteosarcoma 29415187 Microarray is an efficient tool for circRNA profiling. Li S, Teng S, Xu J, Su G, Zhang Y, Zhao J, Zhang S, Wang H, Qin W, Lu ZJ, Guo Y, Zhu Q, Wang D. Brief Bioinform. 2018 up microarray, qRT-PCR paired cervical tumor and normal tissue hsa_circRNA_0087620 circRNA homo sapiens osteosarcoma 29415187 Microarray is an efficient tool for circRNA profiling. Li S, Teng S, Xu J, Su G, Zhang Y, Zhao J, Zhang S, Wang H, Qin W, Lu ZJ, Guo Y, Zhu Q, Wang D. Brief Bioinform. 2018 up microarray, qRT-PCR paired cervical tumor and normal tissue Circular BANP circRNA homo sapiens BANP colorectal cancer 28103507 Circular BANP, an upregulated circular RNA that modulates cell proliferation in colorectal cancer. Zhu M, Xu Y, Chen Y, Yan F. Biomed Pharmacother. 2017 overexpressed in CRC microarray, qRT-PCR, FISH paired CRC cancerous and adjacent normal tissues, HCT116, HT29, SW620, SW480, HCT15 Knockdown of circ-BANP with siRNA significantly attenuate the proliferation of CRC cells. loss of function HT29, HCT116 hsa_circRNA_103809 circRNA homo sapiens ZFR Colorectal cancer 28349836 Identification of differentially expressed circular RNAs in human colorectal cancer. Zhang P, Zuo Z, Shang W, Wu A, Bi R, Wu J, Li S, Sun X, Jiang L. Tumour Biol. 2017 downregulated microarray, qRT-PCR paired CRC tissues and matched adjacent non-cancerous tissue samples ROC curve of hsa_circRNA_103809 was 0.699 (p < 0.0001). The expression level of hsa_circRNA_103809 was significantly associated with lymph node metastasis (p = 0.021) and TNM stage (p = 0.011). paired CRC tissues and matched adjacent non-cancerous tissue samples hsa_circRNA_104700 circRNA homo sapiens PTK2 Colorectal cancer 28349836 Identification of differentially expressed circular RNAs in human colorectal cancer. Zhang P, Zuo Z, Shang W, Wu A, Bi R, Wu J, Li S, Sun X, Jiang L. Tumour Biol. 2017 downregulated microarray, qRT-PCR paired CRC tissues and matched adjacent non-cancerous tissue samples ROC curve of hsa_circRNA_104700 was and 0.616 (p < 0.0001). The expression level of hsa_circRNA_104700 was significantly correlated with distal metastasis (p = 0.036). paired CRC tissues and matched adjacent non-cancerous tissue samples CircRNA 100876 circRNA homo sapiens non-small cell lung cancer 28343871 Over-expression of CircRNA_100876 in non-small cell lung cancer and its prognostic value. Yao JT, Zhao SH, Liu QP, Lv MQ, Zhou DX, Liao ZJ, Nan KJ. Pathol Res Pract. 2017 circRNA100876 was upregulated in NSCLC tissues qRT-PCR paired NSCLC and adjacent non-tumor tissue specimens Associations of circRNA 100876 expression with clinicopathological characteristics of patients with NSCLC. paired NSCLC and adjacent non-tumor tissue specimens circPVT1 circRNA homo sapiens PVT1 osteosarcoma 29559849 Overexpressed circPVT1, a potential new circular RNA biomarker, contributes to doxorubicin and cisplatin resistance of osteosarcoma cells by regulating ABCB1. Kun-Peng Z, Xiao-Long M, Chun-Lin Z. Int J Biol Sci. 2018 up-regulated qRT-PCR paired OS and paracancerous tissues, blood samples from 50 OS patients before surgery, other 20 patients with benign bone tumor (eight cases of osteoclastoma, twelve cases of fibrous dysplasia) and 20 age- and sex-matched healthy individuals as the control group, SaoS2, KHOS, U2OS, MG63 CircPVT1 knockdown partly reverses the doxorubicin and cisplatin resistance of OS cells in vitro. CircPVT1 knockdown reduces the expression of classical multidrug resistance related gene-ABCB1 in OS cells. Serum circPVT1 may be a better diagnostic biomarker than ALP in OS. loss of function MG63R, U2OSR blood samples from 50 OS patients before surgery, other 20 patients with benign bone tumor (eight cases of osteoclastoma, twelve cases of fibrous dysplasia) and 20 age- and sex-matched healthy individuals as the control group circRNA 0000673 circRNA homo sapiens ovarian endometriosis 29334789 Circular RNA expression in ovarian endometriosis. Shen L, Zhang Y, Zhou W, Peng Z, Hong X, Zhang Y. Epigenomics. 2018 Significantly lower expressed in ovarian endometriomas compared with eutopic endometrium microarray, qRT-PCR paired ovarian endometriomas and eutopic endometrium cCYP2C8 circRNA homo sapiens CYP2C8 hepatocellular carcinoma 29378234 Circular RNA cSMARCA5 inhibits growth and metastasis in hepatocellular carcinoma. Yu J, Xu QG, Wang ZG, Yang Y, Zhang L, Ma JZ, Sun SH, Yang F, Zhou WP. J Hepatol. 2018 downregulated in HCC RNA-seq, northern blots, qRT-PCR pairs of HCC and corresponding adjacent noncancerous liver tissues cKCNN2 circRNA homo sapiens KCNN2 hepatocellular carcinoma 29378234 Circular RNA cSMARCA5 inhibits growth and metastasis in hepatocellular carcinoma. Yu J, Xu QG, Wang ZG, Yang Y, Zhang L, Ma JZ, Sun SH, Yang F, Zhou WP. J Hepatol. 2018 downregulated in HCC RNA-seq, northern blots, qRT-PCR pairs of HCC and corresponding adjacent noncancerous liver tissues cLIFR circRNA homo sapiens LIFR hepatocellular carcinoma 29378234 Circular RNA cSMARCA5 inhibits growth and metastasis in hepatocellular carcinoma. Yu J, Xu QG, Wang ZG, Yang Y, Zhang L, Ma JZ, Sun SH, Yang F, Zhou WP. J Hepatol. 2018 downregulated in HCC RNA-seq, northern blots, qRT-PCR pairs of HCC and corresponding adjacent noncancerous liver tissues cPIK3R1 circRNA homo sapiens PIK3R1 hepatocellular carcinoma 29378234 Circular RNA cSMARCA5 inhibits growth and metastasis in hepatocellular carcinoma. Yu J, Xu QG, Wang ZG, Yang Y, Zhang L, Ma JZ, Sun SH, Yang F, Zhou WP. J Hepatol. 2018 downregulated in HCC RNA-seq, northern blots, qRT-PCR pairs of HCC and corresponding adjacent noncancerous liver tissues cDNAJC6 circRNA homo sapiens DNAJC6 hepatocellular carcinoma 29378234 Circular RNA cSMARCA5 inhibits growth and metastasis in hepatocellular carcinoma. Yu J, Xu QG, Wang ZG, Yang Y, Zhang L, Ma JZ, Sun SH, Yang F, Zhou WP. J Hepatol. 2018 upregulated in HCC RNA-seq, northern blots, qRT-PCR pairs of HCC and corresponding adjacent noncancerous liver tissues cGPC3 circRNA homo sapiens GPC3 hepatocellular carcinoma 29378234 Circular RNA cSMARCA5 inhibits growth and metastasis in hepatocellular carcinoma. Yu J, Xu QG, Wang ZG, Yang Y, Zhang L, Ma JZ, Sun SH, Yang F, Zhou WP. J Hepatol. 2018 upregulated in HCC RNA-seq, northern blots, qRT-PCR pairs of HCC and corresponding adjacent noncancerous liver tissues cME1 circRNA homo sapiens ME1 hepatocellular carcinoma 29378234 Circular RNA cSMARCA5 inhibits growth and metastasis in hepatocellular carcinoma. Yu J, Xu QG, Wang ZG, Yang Y, Zhang L, Ma JZ, Sun SH, Yang F, Zhou WP. J Hepatol. 2018 upregulated in HCC RNA-seq, northern blots, qRT-PCR pairs of HCC and corresponding adjacent noncancerous liver tissues cPVT1 circRNA homo sapiens PVT1 hepatocellular carcinoma 29378234 Circular RNA cSMARCA5 inhibits growth and metastasis in hepatocellular carcinoma. Yu J, Xu QG, Wang ZG, Yang Y, Zhang L, Ma JZ, Sun SH, Yang F, Zhou WP. J Hepatol. 2018 upregulated in HCC RNA-seq, northern blots, qRT-PCR pairs of HCC and corresponding adjacent noncancerous liver tissues cSATB2 circRNA homo sapiens SATB2 hepatocellular carcinoma 29378234 Circular RNA cSMARCA5 inhibits growth and metastasis in hepatocellular carcinoma. Yu J, Xu QG, Wang ZG, Yang Y, Zhang L, Ma JZ, Sun SH, Yang F, Zhou WP. J Hepatol. 2018 upregulated in HCC RNA-seq, northern blots, qRT-PCR pairs of HCC and corresponding adjacent noncancerous liver tissues circ-LDLRAD3 circRNA homo sapiens LDLRAD3 pancreatic carcinoma 29307994 Circular RNA circ-LDLRAD3 as a biomarker in diagnosis of pancreatic cancer. Yang F, Liu DY, Guo JT, Ge N, Zhu P, Liu X, Wang S, Wang GX, Sun SY. World J Gastroenterol. 2017 Circ-LDLRAD3 was up-regulated in pancreatic cancer cell lines (P < 0.01), pancreatic cancer tissues (P < 0.01), and plasma samples from patients with pancreatic cancer (P < 0.01). qRT-PCR pancreatic cancer and their paired adjacent pancreatic tissues, HPC-Y5, HPDE6-C7, Capan-2, Panc-1, SW1990, AsPC-1 Expression of circ-LDLRAD3 was correlated with clinical stage (P = 0.022), T classification (P = 0.003), venous invasion (P = 0.025), and lymphatic invasion (P = 0.008). Potential diagnostic value of circ-LDLRAD3 as a biomarker in pancreatic cancer. pancreatic cancer and their paired adjacent pancreatic tissues Circ-FBXW7 circRNA homo sapiens FBXW7 Glioma 28903484 Novel Role of FBXW7 Circular RNA in Repressing Glioma Tumorigenesis. Yang Y, Gao X, Zhang M, Yan S, Sun C, Xiao F, Huang N, Yang X, Zhao K, Zhou H, Huang S, Xie B, Zhang N. J Natl Cancer Inst. 2018 Circ-FBXW7 is abundantly expressed in the normal human brain RNA-seq, northern blots, sanger sequencing pathologically diagnosed glioblastoma samples and their paired adjacent normal brain tissues, U251, U373 HS683, SW1783, HEK293T The spanning junction open reading frame in circ-FBXW7 driven by internal ribosome entry site encodes a novel 21-kDa protein, which we termed FBXW7-185aa. Upregulation of FBXW7-185aa in cancer cells inhibited proliferation and cell cycle acceleration, while knockdown of FBXW7-185aa promoted malignant phenotypes invitro and invivo. FBXW7-185aa reduced the half-life of c-Myc by antagonizing USP28-induced c-Myc stabilization. Moreover, circ-FBXW7 and FBXW7-185aa levels were reduced in glioblastoma clinical samples compared with their paired tumor-adjacent tissues (P < .001). Circ-FBXW7 expression positively associated with glioblastoma patient overall survival (P = .03). loss of function, gain of function U251, U373 HS683, SW1783, HEK293T Four-week-old female BALB/c-nu mice pathologically diagnosed glioblastoma samples and their paired adjacent normal brain tissues circ-DNAJ6C circRNA homo sapiens DNAJ6C cardiovascular diseases 28676412 Identification of circular RNAs with host gene-independent expression in human model systems for cardiac differentiation and disease. Siede D, Rapti K, Gorska AA, Katus HA, Altmüller J, Boeckel JN, Meder B, Maack C, Völkers M, Müller OJ, Backs J, Dieterich C. J Mol Cell Cardiol. 2017 Significantly decreased in circRNA abundance in patients with dilated cardiomyopathy (DCM) vs. control patients (patients with non-failing hearts, NF). RNA-seq, qRT-PCR patients with dilated cardiomyopathy (DCM), control patients (patients with non-failing hearts, NF). circ-ATXN10 circRNA homo sapiens ATXN10 cardiovascular diseases 28676412 Identification of circular RNAs with host gene-independent expression in human model systems for cardiac differentiation and disease. Siede D, Rapti K, Gorska AA, Katus HA, Altmüller J, Boeckel JN, Meder B, Maack C, Völkers M, Müller OJ, Backs J, Dieterich C. J Mol Cell Cardiol. 2017 Significantly increased in circRNA abundance in patients with dilated cardiomyopathy (DCM) vs. control patients (patients with non-failing hearts, NF). RNA-seq, qRT-PCR patients with dilated cardiomyopathy (DCM), control patients (patients with non-failing hearts, NF). circ-CHD7 circRNA homo sapiens CHD7 cardiovascular diseases 28676412 Identification of circular RNAs with host gene-independent expression in human model systems for cardiac differentiation and disease. Siede D, Rapti K, Gorska AA, Katus HA, Altmüller J, Boeckel JN, Meder B, Maack C, Völkers M, Müller OJ, Backs J, Dieterich C. J Mol Cell Cardiol. 2017 Significantly increased in circRNA abundance in patients with dilated cardiomyopathy (DCM) vs. control patients (patients with non-failing hearts, NF). RNA-seq, qRT-PCR patients with dilated cardiomyopathy (DCM), control patients (patients with non-failing hearts, NF). circ-SLC8A1 circRNA homo sapiens SLC8A1 cardiovascular diseases 28676412 Identification of circular RNAs with host gene-independent expression in human model systems for cardiac differentiation and disease. Siede D, Rapti K, Gorska AA, Katus HA, Altmüller J, Boeckel JN, Meder B, Maack C, Völkers M, Müller OJ, Backs J, Dieterich C. J Mol Cell Cardiol. 2017 Significantly increased in circRNA abundance in patients with dilated cardiomyopathy (DCM) vs. control patients (patients with non-failing hearts, NF). RNA-seq, qRT-PCR patients with dilated cardiomyopathy (DCM), control patients (patients with non-failing hearts, NF). circRNA_092516 circRNA homo sapiens Rheumatoid Arthritis 28618429 Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Rheumatoid Arthritis Patients. Ouyang Q, Wu J, Jiang Z, Zhao J, Wang R, Lou A, Zhu D, Shi GP, Yang M. Cell Physiol Biochem. 2017 significantly elevated in PBMCs from RA patients. microarray, qRT-PCR PBMCs from RA patients and controls circRNA_003524 circRNA homo sapiens Rheumatoid Arthritis 28618429 Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Rheumatoid Arthritis Patients. Ouyang Q, Wu J, Jiang Z, Zhao J, Wang R, Lou A, Zhu D, Shi GP, Yang M. Cell Physiol Biochem. 2017 significantly elevated in PBMCs from RA patients. circRNA_003524 has significant value of RA diagnosis (AUC=0.683,P<0.020) microarray, qRT-PCR PBMCs from RA patients and controls circRNA_101873 circRNA homo sapiens Rheumatoid Arthritis 28618429 Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Rheumatoid Arthritis Patients. Ouyang Q, Wu J, Jiang Z, Zhao J, Wang R, Lou A, Zhu D, Shi GP, Yang M. Cell Physiol Biochem. 2017 significantly elevated in PBMCs from RA patients. circRNA_101873 has significant value of RA diagnosis (AUC=0.676,P<0.026) microarray, qRT-PCR PBMCs from RA patients and controls circRNA_103047 circRNA homo sapiens Rheumatoid Arthritis 28618429 Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Rheumatoid Arthritis Patients. Ouyang Q, Wu J, Jiang Z, Zhao J, Wang R, Lou A, Zhu D, Shi GP, Yang M. Cell Physiol Biochem. 2017 significantly elevated in PBMCs from RA patients. circRNA_103047 has significant value of RA diagnosis (AUC=0.671,P<0.030) microarray, qRT-PCR PBMCs from RA patients and controls circRNA_104871 circRNA homo sapiens Rheumatoid Arthritis 28618429 Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Rheumatoid Arthritis Patients. Ouyang Q, Wu J, Jiang Z, Zhao J, Wang R, Lou A, Zhu D, Shi GP, Yang M. Cell Physiol Biochem. 2017 significantly elevated in PBMCs from RA patients. circRNA_104871 has significant value of RA diagnosis (AUC=0.833,P<0.001) microarray, qRT-PCR PBMCs from RA patients and controls hsa_circRNA_005086 circRNA homo sapiens Active Tuberculosis 29448254 Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Active Tuberculosis Patients. Huang ZK, Yao FY, Xu JQ, Deng Z, Su RG, Peng YP, Luo Q, Li JM. Cell Physiol Biochem. 2018 The levels were significantly elevated in PBMCs from TB patients as compared to healthy controls microarray, qRT-PCR PBMCs from TB patients and healthy controls hsa_circRNA_009024 circRNA homo sapiens Active Tuberculosis 29448254 Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Active Tuberculosis Patients. Huang ZK, Yao FY, Xu JQ, Deng Z, Su RG, Peng YP, Luo Q, Li JM. Cell Physiol Biochem. 2018 The levels were significantly elevated in PBMCs from TB patients as compared to healthy controls microarray, qRT-PCR PBMCs from TB patients and healthy controls hsa_circRNA_001937 circRNA homo sapiens Active Tuberculosis 29448254 Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Active Tuberculosis Patients. Huang ZK, Yao FY, Xu JQ, Deng Z, Su RG, Peng YP, Luo Q, Li JM. Cell Physiol Biochem. 2018 The levels were significantly elevated in PBMCs from TB patients as compared to healthy controls. Hsa_circRNA_001937 was significantly increased in patients with TB compared with patients with pneumonia, COPD and lung cancer. Hsa_circRNA_001937 was correlated with TB severity (r = 0.4053, P = 0.010) and its expression significantly decreased after treatment. microarray, qRT-PCR PBMCs from TB patients and healthy controls hsa_circRNA_102101 circRNA homo sapiens Active Tuberculosis 29448254 Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Active Tuberculosis Patients. Huang ZK, Yao FY, Xu JQ, Deng Z, Su RG, Peng YP, Luo Q, Li JM. Cell Physiol Biochem. 2018 The levels were significantly reduced in PBMCs from TB patients as compared to healthy controls microarray, qRT-PCR PBMCs from TB patients and healthy controls hsa_circRNA_104296 circRNA homo sapiens Active Tuberculosis 29448254 Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Active Tuberculosis Patients. Huang ZK, Yao FY, Xu JQ, Deng Z, Su RG, Peng YP, Luo Q, Li JM. Cell Physiol Biochem. 2018 The levels were significantly reduced in PBMCs from TB patients as compared to healthy controls microarray, qRT-PCR PBMCs from TB patients and healthy controls hsa_circRNA_104964 circRNA homo sapiens Active Tuberculosis 29448254 Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Active Tuberculosis Patients. Huang ZK, Yao FY, Xu JQ, Deng Z, Su RG, Peng YP, Luo Q, Li JM. Cell Physiol Biochem. 2018 The levels were significantly reduced in PBMCs from TB patients as compared to healthy controls microarray, qRT-PCR PBMCs from TB patients and healthy controls circCRKL circRNA homo sapiens CRKL Osteogenesis 28598284 The Circular RNA Landscape of Periodontal Ligament Stem Cells During Osteogenesis. Zheng Y, Li X, Huang Y, Jia L, Li W. J Periodontol. 2017 To validate the RNA-seq results, we assayed the head-to-tail splicing of four well-known candidates by qRT-PCR with divergent primers. The circular transcripts of CRKL, RIMS1, MAN1A2 and ETFA were detected, and the relative expression of these genes was consistent between qRT-PCR and RNA-seq. qRT-PCR, RNA-seq periodontal ligament stem cells circETFA circRNA homo sapiens ETFA Osteogenesis 28598284 The Circular RNA Landscape of Periodontal Ligament Stem Cells During Osteogenesis. Zheng Y, Li X, Huang Y, Jia L, Li W. J Periodontol. 2017 To validate the RNA-seq results, we assayed the head-to-tail splicing of four well-known candidates by qRT-PCR with divergent primers. The circular transcripts of CRKL, RIMS1, MAN1A2 and ETFA were detected, and the relative expression of these genes was consistent between qRT-PCR and RNA-seq. qRT-PCR, RNA-seq periodontal ligament stem cells circMAN1A2 circRNA homo sapiens MAN1A2 Osteogenesis 28598284 The Circular RNA Landscape of Periodontal Ligament Stem Cells During Osteogenesis. Zheng Y, Li X, Huang Y, Jia L, Li W. J Periodontol. 2017 To validate the RNA-seq results, we assayed the head-to-tail splicing of four well-known candidates by qRT-PCR with divergent primers. The circular transcripts of CRKL, RIMS1, MAN1A2 and ETFA were detected, and the relative expression of these genes was consistent between qRT-PCR and RNA-seq. qRT-PCR, RNA-seq periodontal ligament stem cells circRIMS1 circRNA homo sapiens RIMS1 Osteogenesis 28598284 The Circular RNA Landscape of Periodontal Ligament Stem Cells During Osteogenesis. Zheng Y, Li X, Huang Y, Jia L, Li W. J Periodontol. 2017 To validate the RNA-seq results, we assayed the head-to-tail splicing of four well-known candidates by qRT-PCR with divergent primers. The circular transcripts of CRKL, RIMS1, MAN1A2 and ETFA were detected, and the relative expression of these genes was consistent between qRT-PCR and RNA-seq. qRT-PCR, RNA-seq periodontal ligament stem cells circRNA IFF01 circRNA homo sapiens IFF01 29197342 Identification and integrated analysis of differentially expressed lncRNAs and circRNAs reveal the potential ceRNA networks during PDLSC osteogenic differentiation. Gu X, Li M, Jin Y, Liu D, Wei F. BMC Genet. 2017 Down-regulated in the induced periodontal ligament stem cells compared to the non-induced group. RNA-seq, qRT-PCR periodontal ligament stem cells circRNA NTNG1 circRNA homo sapiens NTNG1 29197342 Identification and integrated analysis of differentially expressed lncRNAs and circRNAs reveal the potential ceRNA networks during PDLSC osteogenic differentiation. Gu X, Li M, Jin Y, Liu D, Wei F. BMC Genet. 2017 Down-regulated in the induced periodontal ligament stem cells compared to the non-induced group. RNA-seq, qRT-PCR periodontal ligament stem cells circRNA PLOD2 circRNA homo sapiens PLOD2 29197342 Identification and integrated analysis of differentially expressed lncRNAs and circRNAs reveal the potential ceRNA networks during PDLSC osteogenic differentiation. Gu X, Li M, Jin Y, Liu D, Wei F. BMC Genet. 2017 Down-regulated in the induced periodontal ligament stem cells compared to the non-induced group. RNA-seq, qRT-PCR periodontal ligament stem cells circRNA SMO circRNA homo sapiens SMO 29197342 Identification and integrated analysis of differentially expressed lncRNAs and circRNAs reveal the potential ceRNA networks during PDLSC osteogenic differentiation. Gu X, Li M, Jin Y, Liu D, Wei F. BMC Genet. 2017 Down-regulated in the induced periodontal ligament stem cells compared to the non-induced group. RNA-seq, qRT-PCR periodontal ligament stem cells circRNA SMURF2 circRNA homo sapiens SMURF2 29197342 Identification and integrated analysis of differentially expressed lncRNAs and circRNAs reveal the potential ceRNA networks during PDLSC osteogenic differentiation. Gu X, Li M, Jin Y, Liu D, Wei F. BMC Genet. 2017 Down-regulated in the induced periodontal ligament stem cells compared to the non-induced group. RNA-seq, qRT-PCR periodontal ligament stem cells circRNA NCOA3 circRNA homo sapiens NCOA3 29197342 Identification and integrated analysis of differentially expressed lncRNAs and circRNAs reveal the potential ceRNA networks during PDLSC osteogenic differentiation. Gu X, Li M, Jin Y, Liu D, Wei F. BMC Genet. 2017 Up-regulated in the induced periodontal ligament stem cells compared to the non-induced group. RNA-seq, qRT-PCR periodontal ligament stem cells circRNA SKIL circRNA homo sapiens SKIL 29197342 Identification and integrated analysis of differentially expressed lncRNAs and circRNAs reveal the potential ceRNA networks during PDLSC osteogenic differentiation. Gu X, Li M, Jin Y, Liu D, Wei F. BMC Genet. 2017 Up-regulated in the induced periodontal ligament stem cells compared to the non-induced group. RNA-seq, qRT-PCR periodontal ligament stem cells ciRS-7 circRNA homo sapiens CDR1 29197342 Identification and integrated analysis of differentially expressed lncRNAs and circRNAs reveal the potential ceRNA networks during PDLSC osteogenic differentiation. Gu X, Li M, Jin Y, Liu D, Wei F. BMC Genet. 2017 Up-regulated in the induced periodontal ligament stem cells compared to the non-induced group. RNA-seq, qRT-PCR periodontal ligament stem cells hsa-circRNA5974-1 circRNA homo sapiens coronary artery disease 28045102 Peripheral blood circular RNA hsa_circ_0124644 can be used as a diagnostic biomarker of coronary artery disease. Zhao Z, Li X, Gao C, Jian D, Hao P, Rao L, Li M. Sci Rep. 2017 We verified the 5 candidate biomarkers by qPCR in another independent cohort consisting of 30 control subjects (CADS = 0, n = 30) and 30 CAD patients with different CADS (CADS 1¨C22, n = 10; CADS 23¨C32, n = 10; CADS > 33, n = 10). The results confirmed the findings of the microarray analysis, as the levels of these 5 circRNAs were significantly increased in the CAD patients; there was a 2.7-fold change in the expression of hsa_circ_0124644, and 2.2-, 2.1-, 2.0-, and 2.1-fold changes in the expression levels of hsa_circ_0082081, hsa_circ_0113854, hsa_circ_0098964 and hsa-circRNA5974-1,respectively. qRT-PCR, microarray peripheral blood from 12 CAD patients and 12 controls has_circRNA_104820 circRNA homo sapiens preeclampsia 27606420 Potential Significance of Circular RNA in Human Placental Tissue for Patients with Preeclampsia. Qian Y, Lu Y, Rui C, Qian Y, Cai M, Jia R. Cell Physiol Biochem. 2016 Significantly up-regulated in the experimental group compared with the controls. qRT-PCR, microarray placental tissues of pregnant women with preeclampsia hsa_circRNA_100782 circRNA homo sapiens preeclampsia 27606420 Potential Significance of Circular RNA in Human Placental Tissue for Patients with Preeclampsia. Qian Y, Lu Y, Rui C, Qian Y, Cai M, Jia R. Cell Physiol Biochem. 2016 Significantly up-regulated in the experimental group compared with the controls. qRT-PCR, microarray placental tissues of pregnant women with preeclampsia hsa_circRNA_102682 circRNA homo sapiens preeclampsia 27606420 Potential Significance of Circular RNA in Human Placental Tissue for Patients with Preeclampsia. Qian Y, Lu Y, Rui C, Qian Y, Cai M, Jia R. Cell Physiol Biochem. 2016 Significantly up-regulated in the experimental group compared with the controls. qRT-PCR, microarray placental tissues of pregnant women with preeclampsia circAKNRD12 circRNA homo sapiens AKNRD12 24799715 Noninvasive in vivo monitoring of tissue-specific global gene expression in humans. Koh W, Pan W, Gawad C, Fan HC, Kerchner GA, Wyss-Coray T, Blumenfeld YJ, El-Sayed YY, Quake SR. Proc Natl Acad Sci U S A. 2014 circRNA in the plasma microarray, RT-PCR plasma samples were collected from four nonpregnant subjects and pregnant women circBPTF circRNA homo sapiens 24799715 Noninvasive in vivo monitoring of tissue-specific global gene expression in humans. Koh W, Pan W, Gawad C, Fan HC, Kerchner GA, Wyss-Coray T, Blumenfeld YJ, El-Sayed YY, Quake SR. Proc Natl Acad Sci U S A. 2014 circRNA in the plasma microarray, RT-PCR plasma samples were collected from four nonpregnant subjects and pregnant women circFNDC3B circRNA homo sapiens FNDC3B 24799715 Noninvasive in vivo monitoring of tissue-specific global gene expression in humans. Koh W, Pan W, Gawad C, Fan HC, Kerchner GA, Wyss-Coray T, Blumenfeld YJ, El-Sayed YY, Quake SR. Proc Natl Acad Sci U S A. 2014 circRNA in the plasma microarray, RT-PCR plasma samples were collected from four nonpregnant subjects and pregnant women circMAN1A2 circRNA homo sapiens MAN1A2 24799715 Noninvasive in vivo monitoring of tissue-specific global gene expression in humans. Koh W, Pan W, Gawad C, Fan HC, Kerchner GA, Wyss-Coray T, Blumenfeld YJ, El-Sayed YY, Quake SR. Proc Natl Acad Sci U S A. 2014 circRNA in the plasma microarray, RT-PCR plasma samples were collected from four nonpregnant subjects and pregnant women circSPECC1 circRNA homo sapiens SPECC1 24799715 Noninvasive in vivo monitoring of tissue-specific global gene expression in humans. Koh W, Pan W, Gawad C, Fan HC, Kerchner GA, Wyss-Coray T, Blumenfeld YJ, El-Sayed YY, Quake SR. Proc Natl Acad Sci U S A. 2014 circRNA in the plasma microarray, RT-PCR plasma samples were collected from four nonpregnant subjects and pregnant women MAN1A2 EX5-2 circRNA homo sapiens 26660425 Circular RNA enrichment in platelets is a signature of transcriptome degradation. Alhasan AA, Izuogu OG, Al-Balool HH, Steyn JS, Evans A, Colzani M, Ghevaert C, Mountford JC, Marenah L, Elliott DJ, Santibanez-Koref M, Jackson MS. Blood. 2016 enriched in platelets RNA-seq, qRT-PCR platelets, RBCs, PBMCs, cerebellum, thalamus, heart, lung, liver, kidney, spinal cord MAN1A2 EX4-2 circRNA homo sapiens 26660425 Circular RNA enrichment in platelets is a signature of transcriptome degradation. Alhasan AA, Izuogu OG, Al-Balool HH, Steyn JS, Evans A, Colzani M, Ghevaert C, Mountford JC, Marenah L, Elliott DJ, Santibanez-Koref M, Jackson MS. Blood. 2016 enriched in platelets RNA-seq, qRT-PCR platelets, RBCs, PBMCs, thalamus, heart, lung, liver, kidney, spinal cord PHC3 EX6-5 circRNA homo sapiens PHC3 26660425 Circular RNA enrichment in platelets is a signature of transcriptome degradation. Alhasan AA, Izuogu OG, Al-Balool HH, Steyn JS, Evans A, Colzani M, Ghevaert C, Mountford JC, Marenah L, Elliott DJ, Santibanez-Koref M, Jackson MS. Blood. 2016 enriched in platelets RNA-seq, qRT-PCR platelets, RBCs, PBMCs, thalamus, heart, lung, liver, kidney, spinal cord PHC3 EX7-5 circRNA homo sapiens PHC3 26660425 Circular RNA enrichment in platelets is a signature of transcriptome degradation. Alhasan AA, Izuogu OG, Al-Balool HH, Steyn JS, Evans A, Colzani M, Ghevaert C, Mountford JC, Marenah L, Elliott DJ, Santibanez-Koref M, Jackson MS. Blood. 2016 enriched in platelets RNA-seq, qRT-PCR platelets, RBCs, PBMCs, thalamus, heart, lung, liver, kidney, spinal cord PNN EX 8-7 circRNA homo sapiens PNN 26660425 Circular RNA enrichment in platelets is a signature of transcriptome degradation. Alhasan AA, Izuogu OG, Al-Balool HH, Steyn JS, Evans A, Colzani M, Ghevaert C, Mountford JC, Marenah L, Elliott DJ, Santibanez-Koref M, Jackson MS. Blood. 2016 enriched in platelets RNA-seq, qRT-PCR platelets, RBCs, PBMCs, thalamus, heart, lung, liver, kidney, spinal cord PPA2 EX 5-2 circRNA homo sapiens PPA2 26660425 Circular RNA enrichment in platelets is a signature of transcriptome degradation. Alhasan AA, Izuogu OG, Al-Balool HH, Steyn JS, Evans A, Colzani M, Ghevaert C, Mountford JC, Marenah L, Elliott DJ, Santibanez-Koref M, Jackson MS. Blood. 2016 enriched in platelets RNA-seq, qRT-PCR platelets, RBCs, PBMCs, thalamus, heart, lung, liver, kidney, spinal cord PPA2 EX 6-2 circRNA homo sapiens PPA2 26660425 Circular RNA enrichment in platelets is a signature of transcriptome degradation. Alhasan AA, Izuogu OG, Al-Balool HH, Steyn JS, Evans A, Colzani M, Ghevaert C, Mountford JC, Marenah L, Elliott DJ, Santibanez-Koref M, Jackson MS. Blood. 2016 enriched in platelets RNA-seq, qRT-PCR platelets, RBCs, PBMCs, thalamus, heart, lung, liver, kidney, spinal cord SAMARCA5 EX 16-15 circRNA homo sapiens SAMARCA5 26660425 Circular RNA enrichment in platelets is a signature of transcriptome degradation. Alhasan AA, Izuogu OG, Al-Balool HH, Steyn JS, Evans A, Colzani M, Ghevaert C, Mountford JC, Marenah L, Elliott DJ, Santibanez-Koref M, Jackson MS. Blood. 2016 enriched in platelets RNA-seq, qRT-PCR platelets, RBCs, PBMCs, thalamus, heart, lung, liver, kidney, spinal cord UBXN7 EX 5-3 circRNA homo sapiens UBXN7 26660425 Circular RNA enrichment in platelets is a signature of transcriptome degradation. Alhasan AA, Izuogu OG, Al-Balool HH, Steyn JS, Evans A, Colzani M, Ghevaert C, Mountford JC, Marenah L, Elliott DJ, Santibanez-Koref M, Jackson MS. Blood. 2016 enriched in platelets RNA-seq, qRT-PCR platelets, RBCs, PBMCs, thalamus, heart, lung, liver, kidney, spinal cord UBXN7 EX 5-4 circRNA homo sapiens UBXN7 26660425 Circular RNA enrichment in platelets is a signature of transcriptome degradation. Alhasan AA, Izuogu OG, Al-Balool HH, Steyn JS, Evans A, Colzani M, Ghevaert C, Mountford JC, Marenah L, Elliott DJ, Santibanez-Koref M, Jackson MS. Blood. 2016 enriched in platelets RNA-seq, qRT-PCR platelets, RBCs, PBMCs, thalamus, heart, lung, liver, kidney, spinal cord circDENND4C circRNA homo sapiens DENND4C breast cancer 28739726 HIF1α-associated circDENND4C Promotes Proliferation of Breast Cancer Cells in Hypoxic Environment. Liang G, Liu Z, Tan L, Su AN, Jiang WG, Gong C. Anticancer Res. 2017 hypoxia-associated circRNAs in endothelial cells after hypoxia induction qRT-PCR Primary invasive ductal carcinomas of breast and adjacent non-cancerous breast tissues, MCF-7 and MDA-MB-231 CircDENND4C mediates proliferation of breast cancer cells in hypoxic environment. CircDENND4C expression level is positively correlated to HIF1¦Á level and tumor size in breast cancer patients. loss of function MDA-MB-231 Primary invasive ductal carcinomas of breast and adjacent non-cancerous breast tissues Compared to negative control groups, circDENND4C expression was decreased after silencing HIF1¦Á circRNA_102231 circRNA homo sapiens lung cancer 29602132 Increased expression of circRNA_102231 in lung cancer and its clinical significance. Zong L, Sun Q, Zhang H, Chen Z, Deng Y, Li D, Zhang L. Biomed Pharmacother. 2018 circRNA_102231 was upregulated in lung cancer qRT-PCR primary LAC tissues and adjacent non-tissues, BEAS-2B and A549 circRNA_102231 expression was associated with TNM stage and Lymph node metastasis (P < 0.05). The area under the ROC curve (AUC) was 0.897 (Fig. 3), indicating that circRNA_102231 expression level had a potential clinical significance as a tumor marker and had the potential to help diagnosis and monitor therapeutic efficacy. circRNA_102231 inhibition suppressed lung cancer cells proliferation and invasion. loss of function BEAS-2B and A549 primary LAC tissues and adjacent non-tissues hsa_circ_00074 circRNA homo sapiens pulmonary tuberculosis 29371930 Identification and comparison of novel circular RNAs with associated co-expression and competing endogenous RNA networks in pulmonary tuberculosis. Zhang X, Zhu M, Yang R, Zhao W, Hu X, Gan J. Oncotarget. 2017 Upregulated in PTB patients compared to healthy individuals. RNA-seq, qRT-PCR PTB patients, healthy individuals hsa_circRNA_14623 circRNA homo sapiens pulmonary tuberculosis 29371930 Identification and comparison of novel circular RNAs with associated co-expression and competing endogenous RNA networks in pulmonary tuberculosis. Zhang X, Zhu M, Yang R, Zhao W, Hu X, Gan J. Oncotarget. 2017 Upregulated in PTB patients compared to healthy individuals. RNA-seq, qRT-PCR PTB patients, healthy individuals hsa_circRNA_102594 circRNA homo sapiens rheumatoid arthritis 28983619 Circular RNA expression profiles of peripheral blood mononuclear cells in rheumatoid arthritis patients, based on microarray chip technology. Zheng F, Yu X, Huang J, Dai Y. Mol Med Rep. 2017 Significance down-regulated in RA compared to Control. microarray, qRT-PCR RA patients and healthy people age and gender matched hsa_circRNA_101407 circRNA homo sapiens rheumatoid arthritis 28983619 Circular RNA expression profiles of peripheral blood mononuclear cells in rheumatoid arthritis patients, based on microarray chip technology. Zheng F, Yu X, Huang J, Dai Y. Mol Med Rep. 2017 Significance up-regulated in RA compared to Control. microarray, qRT-PCR RA patients and healthy people age and gender matched hsa_circRNA_103334 circRNA homo sapiens rheumatoid arthritis 28983619 Circular RNA expression profiles of peripheral blood mononuclear cells in rheumatoid arthritis patients, based on microarray chip technology. Zheng F, Yu X, Huang J, Dai Y. Mol Med Rep. 2017 Significance up-regulated in RA compared to Control. microarray, qRT-PCR RA patients and healthy people age and gender matched hsa_circRNA_104194 circRNA homo sapiens rheumatoid arthritis 28983619 Circular RNA expression profiles of peripheral blood mononuclear cells in rheumatoid arthritis patients, based on microarray chip technology. Zheng F, Yu X, Huang J, Dai Y. Mol Med Rep. 2017 Significance up-regulated in RA compared to Control. microarray, qRT-PCR RA patients and healthy people age and gender matched hsa_circRNA_104593 circRNA homo sapiens rheumatoid arthritis 28983619 Circular RNA expression profiles of peripheral blood mononuclear cells in rheumatoid arthritis patients, based on microarray chip technology. Zheng F, Yu X, Huang J, Dai Y. Mol Med Rep. 2017 Significance up-regulated in RA compared to Control. microarray, qRT-PCR RA patients and healthy people age and gender matched circRNA SMARCA circRNA homo sapiens SMARCA 29359036 Selective release of circRNAs in platelet-derived extracellular vesicles. Preuber C, Hung LH, Schneider T, Schreiner S, Hardt M, Moebus A, Santoso S, Bindereif A. J Extracell Vesicles. 2018 The expression of circRNA SMARCA was monitored by semi-quantitative RT-PCR and quantitative RT-qPCR in resting and TRAP-10-activated platelets. RNA-seq, qRT-PCR resting and TRAP-10-activated platelets circRNA RAP1B circRNA homo sapiens RAP1B 29359036 Selective release of circRNAs in platelet-derived extracellular vesicles. Preuber C, Hung LH, Schneider T, Schreiner S, Hardt M, Moebus A, Santoso S, Bindereif A. J Extracell Vesicles. 2018 The expression of circRNA RAP1B was monitored by semi-quantitative RT-PCR and quantitative RT-qPCR in resting and TRAP-11-activated platelets. RNA-seq, qRT-PCR resting and TRAP-11-activated platelets circRNA AMD1 circRNA homo sapiens AMD1 29359036 Selective release of circRNAs in platelet-derived extracellular vesicles. Preuber C, Hung LH, Schneider T, Schreiner S, Hardt M, Moebus A, Santoso S, Bindereif A. J Extracell Vesicles. 2018 CircRNA AMD1 is preferentially released into microvesicles and exosomes, compared with its corresponding linear isoform. RNA-seq, qRT-PCR resting and TRAP-12-activated platelets, platelet-derived vesicles circRNA DYRK1A circRNA homo sapiens DYRK1A 29359036 Selective release of circRNAs in platelet-derived extracellular vesicles. Preuber C, Hung LH, Schneider T, Schreiner S, Hardt M, Moebus A, Santoso S, Bindereif A. J Extracell Vesicles. 2018 CircRNA DYRK1A is preferentially released into microvesicles and exosomes, compared with its corresponding linear isoform. RNA-seq, qRT-PCR resting and TRAP-12-activated platelets, platelet-derived vesicles circRNA FAM13B circRNA homo sapiens FAM13B 29359036 Selective release of circRNAs in platelet-derived extracellular vesicles. Preuber C, Hung LH, Schneider T, Schreiner S, Hardt M, Moebus A, Santoso S, Bindereif A. J Extracell Vesicles. 2018 CircRNA FAM13B is preferentially released into exosomes, compared with its corresponding linear isoform. RNA-seq, qRT-PCR resting and TRAP-12-activated platelets, platelet-derived vesicles circRNA NRIP1 circRNA homo sapiens NRIP1 29359036 Selective release of circRNAs in platelet-derived extracellular vesicles. Preuber C, Hung LH, Schneider T, Schreiner S, Hardt M, Moebus A, Santoso S, Bindereif A. J Extracell Vesicles. 2018 CircRNA NRIP1 could be detected in the fractions where exosomes are highly enriched, indicating that circRNA GSE1 is associated with platelet-derived vesicles. RNA-seq, qRT-PCR resting and TRAP-12-activated platelets, platelet-derived vesicles circRNA TMEM30 circRNA homo sapiens TMEM30 29359036 Selective release of circRNAs in platelet-derived extracellular vesicles. Preuber C, Hung LH, Schneider T, Schreiner S, Hardt M, Moebus A, Santoso S, Bindereif A. J Extracell Vesicles. 2018 CircRNA TMEM30 is preferentially released into microvesicles and exosomes, compared with its corresponding linear isoform. RNA-seq, qRT-PCR resting and TRAP-12-activated platelets, platelet-derived vesicles circRNA GSE1 circRNA homo sapiens GSE1 29359036 Selective release of circRNAs in platelet-derived extracellular vesicles. Preuber C, Hung LH, Schneider T, Schreiner S, Hardt M, Moebus A, Santoso S, Bindereif A. J Extracell Vesicles. 2018 The expression of circRNA GSE1 was monitored by semi-quantitative RT-PCR and quantitative RT-qPCR in resting and TRAP-12-activated platelets. CircRNA GSE1 could be detected in the fractions where exosomes are highly enriched, indicating that circRNA GSE1 is associated with platelet-derived vesicles. RNA-seq, qRT-PCR resting and TRAP-12-activated platelets, platelet-derived vesicles circRNA TPTEP1 circRNA homo sapiens TPTEP1 29359036 Selective release of circRNAs in platelet-derived extracellular vesicles. Preuber C, Hung LH, Schneider T, Schreiner S, Hardt M, Moebus A, Santoso S, Bindereif A. J Extracell Vesicles. 2018 The expression of circRNA TPTEP1 was monitored by semi-quantitative RT-PCR and quantitative RT-qPCR in resting and TRAP-13-activated platelets. RNA-seq, qRT-PCR resting and TRAP-13-activated platelets circRNA DYRK1A circRNA homo sapiens DYRK1A 29359036 Selective release of circRNAs in platelet-derived extracellular vesicles. Preuber C, Hung LH, Schneider T, Schreiner S, Hardt M, Moebus A, Santoso S, Bindereif A. J Extracell Vesicles. 2018 The expression of circRNA DYRK1A was monitored by semi-quantitative RT-PCR and quantitative RT-qPCR in resting and TRAP-14-activated platelets. RNA-seq, qRT-PCR resting and TRAP-14-activated platelets Plt-circR4 circRNA homo sapiens Plt 29359036 Selective release of circRNAs in platelet-derived extracellular vesicles. Preuber C, Hung LH, Schneider T, Schreiner S, Hardt M, Moebus A, Santoso S, Bindereif A. J Extracell Vesicles. 2018 The expression of Plt-circR4 was monitored by semi-quantitative RT-PCR and quantitative RT-qPCR in resting and TRAP-15-activated platelets. RNA-seq, qRT-PCR resting and TRAP-15-activated platelets circRNA ACVR2A circRNA homo sapiens ACVR2A 29359036 Selective release of circRNAs in platelet-derived extracellular vesicles. Preuber C, Hung LH, Schneider T, Schreiner S, Hardt M, Moebus A, Santoso S, Bindereif A. J Extracell Vesicles. 2018 The expression of circRNA ACVR2A was monitored by semi-quantitative RT-PCR and quantitative RT-qPCR in resting and TRAP-6-activated platelets. RNA-seq, qRT-PCR resting and TRAP-6-activated platelets circRNA CORO1C circRNA homo sapiens CORO1C 29359036 Selective release of circRNAs in platelet-derived extracellular vesicles. Preuber C, Hung LH, Schneider T, Schreiner S, Hardt M, Moebus A, Santoso S, Bindereif A. J Extracell Vesicles. 2018 The expression of circRNA CORO1C was monitored by semi-quantitative RT-PCR and quantitative RT-qPCR in resting and TRAP-7-activated platelets. RNA-seq, qRT-PCR resting and TRAP-7-activated platelets circRNA FAM13B circRNA homo sapiens FAM13B 29359036 Selective release of circRNAs in platelet-derived extracellular vesicles. Preuber C, Hung LH, Schneider T, Schreiner S, Hardt M, Moebus A, Santoso S, Bindereif A. J Extracell Vesicles. 2018 The expression of circRNA FAM13B was monitored by semi-quantitative RT-PCR and quantitative RT-qPCR in resting and TRAP-8-activated platelets. RNA-seq, qRT-PCR resting and TRAP-8-activated platelets circRNA PCMTD1 circRNA homo sapiens PCMTD1 29359036 Selective release of circRNAs in platelet-derived extracellular vesicles. Preuber C, Hung LH, Schneider T, Schreiner S, Hardt M, Moebus A, Santoso S, Bindereif A. J Extracell Vesicles. 2018 The expression of circRNA PCMTD1 was monitored by semi-quantitative RT-PCR and quantitative RT-qPCR in resting and TRAP-9-activated platelets. RNA-seq, qRT-PCR resting and TRAP-9-activated platelets hsa_circRNA_063981 circRNA homo sapiens Diabetic Retinopathy 28817829 Altered Expression Profile of Circular RNAs in the Serum of Patients with Diabetic Retinopathy Revealed by Microarray. Gu Y, Ke G, Wang L, Zhou E, Zhu K, Wei Y. Ophthalmic Res. 2017 The serum levels of the circRNA were significantly elevated in T2DR relative to the T2DM or control groups, which agrees with the microarray results and demonstrates high reliability of this circRNA profile. microarray, qRT-PCR serum from T2DR, T2DM and control groups hsa_circRNA_404457 circRNA homo sapiens Diabetic Retinopathy 28817829 Altered Expression Profile of Circular RNAs in the Serum of Patients with Diabetic Retinopathy Revealed by Microarray. Gu Y, Ke G, Wang L, Zhou E, Zhu K, Wei Y. Ophthalmic Res. 2017 The serum levels of the circRNA were significantly elevated in T2DR relative to the T2DM or control groups, which agrees with the microarray results and demonstrates high reliability of this circRNA profile. microarray, qRT-PCR serum from T2DR, T3DM and control groups hsa_circRNA_100750 circRNA homo sapiens Diabetic Retinopathy 28817829 Altered Expression Profile of Circular RNAs in the Serum of Patients with Diabetic Retinopathy Revealed by Microarray. Gu Y, Ke G, Wang L, Zhou E, Zhu K, Wei Y. Ophthalmic Res. 2017 The serum levels of the circRNA were significantly elevated in T2DR relative to the T2DM or control groups, which agrees with the microarray results and demonstrates high reliability of this circRNA profile. microarray, qRT-PCR serum from T2DR, T4DM and control groups hsa_circRNA_406918 circRNA homo sapiens Diabetic Retinopathy 28817829 Altered Expression Profile of Circular RNAs in the Serum of Patients with Diabetic Retinopathy Revealed by Microarray. Gu Y, Ke G, Wang L, Zhou E, Zhu K, Wei Y. Ophthalmic Res. 2017 The serum levels of the circRNA were significantly elevated in T2DR relative to the T2DM or control groups, which agrees with the microarray results and demonstrates high reliability of this circRNA profile. microarray, qRT-PCR serum from T2DR, T5DM and control groups hsa_circRNA_104387 circRNA homo sapiens Diabetic Retinopathy 28817829 Altered Expression Profile of Circular RNAs in the Serum of Patients with Diabetic Retinopathy Revealed by Microarray. Gu Y, Ke G, Wang L, Zhou E, Zhu K, Wei Y. Ophthalmic Res. 2017 The serum levels of the circRNA were significantly elevated in T2DR relative to the T2DM or control groups, which agrees with the microarray results and demonstrates high reliability of this circRNA profile. microarray, qRT-PCR serum from T2DR, T6DM and control groups hsa_circRNA_103410 circRNA homo sapiens Diabetic Retinopathy 28817829 Altered Expression Profile of Circular RNAs in the Serum of Patients with Diabetic Retinopathy Revealed by Microarray. Gu Y, Ke G, Wang L, Zhou E, Zhu K, Wei Y. Ophthalmic Res. 2017 The serum levels of the circRNA were significantly elevated in T2DR relative to the T2DM or control groups, which agrees with the microarray results and demonstrates high reliability of this circRNA profile. microarray, qRT-PCR serum from T2DR, T7DM and control groups hsa_circRNA_100192 circRNA homo sapiens Diabetic Retinopathy 28817829 Altered Expression Profile of Circular RNAs in the Serum of Patients with Diabetic Retinopathy Revealed by Microarray. Gu Y, Ke G, Wang L, Zhou E, Zhu K, Wei Y. Ophthalmic Res. 2017 The serum levels of the circRNA were significantly elevated in T2DR relative to the T2DM or control groups, which agrees with the microarray results and demonstrates high reliability of this circRNA profile. microarray, qRT-PCR serum from T2DR, T8DM and control groups circRNA9652 circRNA homo sapiens Esophageal squamous cell carcinoma 29218114 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. Sun J, Yuan X, Li X, Wang D, Shan T, Wang W, Wan Q, Wang X, Yan J, Gao S. Am J Transl Res. 2017 down RNA-seq, qRT-PCR SHEE and SHEEC circRNA9656 circRNA homo sapiens Esophageal squamous cell carcinoma 29218114 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. Sun J, Yuan X, Li X, Wang D, Shan T, Wang W, Wan Q, Wang X, Yan J, Gao S. Am J Transl Res. 2017 down RNA-seq, qRT-PCR SHEE and SHEEC circRNA9658 circRNA homo sapiens Esophageal squamous cell carcinoma 29218114 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. Sun J, Yuan X, Li X, Wang D, Shan T, Wang W, Wan Q, Wang X, Yan J, Gao S. Am J Transl Res. 2017 down RNA-seq, qRT-PCR SHEE and SHEEC circRNA9671 circRNA homo sapiens Esophageal squamous cell carcinoma 29218114 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. Sun J, Yuan X, Li X, Wang D, Shan T, Wang W, Wan Q, Wang X, Yan J, Gao S. Am J Transl Res. 2017 down RNA-seq, qRT-PCR SHEE and SHEEC circRNA9771 circRNA homo sapiens Esophageal squamous cell carcinoma 29218114 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. Sun J, Yuan X, Li X, Wang D, Shan T, Wang W, Wan Q, Wang X, Yan J, Gao S. Am J Transl Res. 2017 down RNA-seq, qRT-PCR SHEE and SHEEC circRNA9777 circRNA homo sapiens Esophageal squamous cell carcinoma 29218114 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. Sun J, Yuan X, Li X, Wang D, Shan T, Wang W, Wan Q, Wang X, Yan J, Gao S. Am J Transl Res. 2017 down RNA-seq, qRT-PCR SHEE and SHEEC circRNA120 circRNA homo sapiens Esophageal squamous cell carcinoma 29218114 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. Sun J, Yuan X, Li X, Wang D, Shan T, Wang W, Wan Q, Wang X, Yan J, Gao S. Am J Transl Res. 2017 up RNA-seq, qRT-PCR SHEE and SHEEC circRNA167 circRNA homo sapiens Esophageal squamous cell carcinoma 29218114 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. Sun J, Yuan X, Li X, Wang D, Shan T, Wang W, Wan Q, Wang X, Yan J, Gao S. Am J Transl Res. 2017 up RNA-seq, qRT-PCR SHEE and SHEEC circRNA2918 circRNA homo sapiens Esophageal squamous cell carcinoma 29218114 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. Sun J, Yuan X, Li X, Wang D, Shan T, Wang W, Wan Q, Wang X, Yan J, Gao S. Am J Transl Res. 2017 up RNA-seq, qRT-PCR SHEE and SHEEC circRNA3594 circRNA homo sapiens Esophageal squamous cell carcinoma 29218114 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. Sun J, Yuan X, Li X, Wang D, Shan T, Wang W, Wan Q, Wang X, Yan J, Gao S. Am J Transl Res. 2017 up RNA-seq, qRT-PCR SHEE and SHEEC circRNA3703 circRNA homo sapiens Esophageal squamous cell carcinoma 29218114 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. Sun J, Yuan X, Li X, Wang D, Shan T, Wang W, Wan Q, Wang X, Yan J, Gao S. Am J Transl Res. 2017 up RNA-seq, qRT-PCR SHEE and SHEEC circRNA3706 circRNA homo sapiens Esophageal squamous cell carcinoma 29218114 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. Sun J, Yuan X, Li X, Wang D, Shan T, Wang W, Wan Q, Wang X, Yan J, Gao S. Am J Transl Res. 2017 up RNA-seq, qRT-PCR SHEE and SHEEC circRNA3707 circRNA homo sapiens Esophageal squamous cell carcinoma 29218114 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. Sun J, Yuan X, Li X, Wang D, Shan T, Wang W, Wan Q, Wang X, Yan J, Gao S. Am J Transl Res. 2017 up RNA-seq, qRT-PCR SHEE and SHEEC circRNA5669 circRNA homo sapiens Esophageal squamous cell carcinoma 29218114 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. Sun J, Yuan X, Li X, Wang D, Shan T, Wang W, Wan Q, Wang X, Yan J, Gao S. Am J Transl Res. 2017 up RNA-seq, qRT-PCR SHEE and SHEEC circRNA7534 circRNA homo sapiens Esophageal squamous cell carcinoma 29218114 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. Sun J, Yuan X, Li X, Wang D, Shan T, Wang W, Wan Q, Wang X, Yan J, Gao S. Am J Transl Res. 2017 up RNA-seq, qRT-PCR SHEE and SHEEC circRNA7535 circRNA homo sapiens Esophageal squamous cell carcinoma 29218114 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. Sun J, Yuan X, Li X, Wang D, Shan T, Wang W, Wan Q, Wang X, Yan J, Gao S. Am J Transl Res. 2017 up RNA-seq, qRT-PCR SHEE and SHEEC circRNA7536 circRNA homo sapiens Esophageal squamous cell carcinoma 29218114 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. Sun J, Yuan X, Li X, Wang D, Shan T, Wang W, Wan Q, Wang X, Yan J, Gao S. Am J Transl Res. 2017 up RNA-seq, qRT-PCR SHEE and SHEEC circRNA7537 circRNA homo sapiens Esophageal squamous cell carcinoma 29218114 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. Sun J, Yuan X, Li X, Wang D, Shan T, Wang W, Wan Q, Wang X, Yan J, Gao S. Am J Transl Res. 2017 up RNA-seq, qRT-PCR SHEE and SHEEC circRNA7673 circRNA homo sapiens Esophageal squamous cell carcinoma 29218114 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. Sun J, Yuan X, Li X, Wang D, Shan T, Wang W, Wan Q, Wang X, Yan J, Gao S. Am J Transl Res. 2017 up RNA-seq, qRT-PCR SHEE and SHEEC circRNA7674 circRNA homo sapiens Esophageal squamous cell carcinoma 29218114 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. Sun J, Yuan X, Li X, Wang D, Shan T, Wang W, Wan Q, Wang X, Yan J, Gao S. Am J Transl Res. 2017 up RNA-seq, qRT-PCR SHEE and SHEEC circRNA7675 circRNA homo sapiens Esophageal squamous cell carcinoma 29218114 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. Sun J, Yuan X, Li X, Wang D, Shan T, Wang W, Wan Q, Wang X, Yan J, Gao S. Am J Transl Res. 2017 up RNA-seq, qRT-PCR SHEE and SHEEC circRNA7676 circRNA homo sapiens Esophageal squamous cell carcinoma 29218114 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. Sun J, Yuan X, Li X, Wang D, Shan T, Wang W, Wan Q, Wang X, Yan J, Gao S. Am J Transl Res. 2017 up RNA-seq, qRT-PCR SHEE and SHEEC circRNA7679 circRNA homo sapiens Esophageal squamous cell carcinoma 29218114 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. Sun J, Yuan X, Li X, Wang D, Shan T, Wang W, Wan Q, Wang X, Yan J, Gao S. Am J Transl Res. 2017 up RNA-seq, qRT-PCR SHEE and SHEEC circRNA8505 circRNA homo sapiens Esophageal squamous cell carcinoma 29218114 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. Sun J, Yuan X, Li X, Wang D, Shan T, Wang W, Wan Q, Wang X, Yan J, Gao S. Am J Transl Res. 2017 up RNA-seq, qRT-PCR SHEE and SHEEC circRNA8506 circRNA homo sapiens Esophageal squamous cell carcinoma 29218114 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. Sun J, Yuan X, Li X, Wang D, Shan T, Wang W, Wan Q, Wang X, Yan J, Gao S. Am J Transl Res. 2017 up RNA-seq, qRT-PCR SHEE and SHEEC circRNA8507 circRNA homo sapiens Esophageal squamous cell carcinoma 29218114 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. Sun J, Yuan X, Li X, Wang D, Shan T, Wang W, Wan Q, Wang X, Yan J, Gao S. Am J Transl Res. 2017 up RNA-seq, qRT-PCR SHEE and SHEEC circRNA904 circRNA homo sapiens Esophageal squamous cell carcinoma 29218114 Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. Sun J, Yuan X, Li X, Wang D, Shan T, Wang W, Wan Q, Wang X, Yan J, Gao S. Am J Transl Res. 2017 up RNA-seq, qRT-PCR SHEE and SHEEC f-circEF1 fusion circRNA homo sapiens EWSR1-FLI1 fusion gene ATGATAAAAACATTATGACCAAAGTGCACGGCAAAAGATATGCTTACAAATTTGACTTCCACGGCATTGCCCAGGCTCTGCAGCCACATCCGACCGAGTCGTCCATGTACAAGTACCCTTCTGACATCTCCTACATGCCTTCCTACCATCTATTCCTCTACACAGCCGACTAGTTATGATCAGAGCAGTTACTCTCAGCAGAACACCTATGGGCAACCGAGCAGCTATGGACAGCAGAGTAGCTATGGTCAACAAAGCAGCTATGGGCAGCAGCCTCCCACTAGTTA Ewing Sarcoma 27040497 Oncogenic Role of Fusion-circRNAs Derived from Cancer-Associated Chromosomal Translocations. Guarnerio J, Bezzi M, Jeong JC, Paffenholz SV, Berry K, Naldini MM, Lo-Coco F, Tay Y, Beck AH, Pandolfi PP. Cell. 2016 f-circEF1 is expressed in SK-NEP-1 sarcoma cell line cells. PCR products sequencing SK-NEP-1 sarcoma cell line - SK-NEP-1 sarcoma cell line circCDYL circRNA homo sapiens CDYL bladder cancer 29263845 Circular RNA expression is abundant and correlated to aggressiveness in early-stage bladder cancer. Okholm TLH, Nielsen MM, Hamilton MP, Christensen LL, Vang S, Hedegaard J, Hansen TB, Kjems J, Dyrskjøt L, Pedersen JS. NPJ Genom Med. 2017 at higher levels in nonmalignant BC cell lines than metastatic BC cell lines RNA-seq, qRT-PCR T24, FL3, HCV29, RT4 and HT1376 cells, non-muscle-invasive bladder cancer samples correlated with BC progression non-muscle-invasive bladder cancer samples circHIPK3 circRNA homo sapiens HIPK3 bladder cancer 29263845 Circular RNA expression is abundant and correlated to aggressiveness in early-stage bladder cancer. Okholm TLH, Nielsen MM, Hamilton MP, Christensen LL, Vang S, Hedegaard J, Hansen TB, Kjems J, Dyrskjøt L, Pedersen JS. NPJ Genom Med. 2017 at higher levels in nonmalignant BC cell lines than metastatic BC cell lines RNA-seq, qRT-PCR, RT-PCR and sanger sequencing T24, FL3, HCV29, RT4 and HT1376 cells, non-muscle-invasive bladder cancer samples correlated with BC progression non-muscle-invasive bladder cancer samples circFNDC3B circRNA homo sapiens FNDC3B bladder cancer 29263845 Circular RNA expression is abundant and correlated to aggressiveness in early-stage bladder cancer. Okholm TLH, Nielsen MM, Hamilton MP, Christensen LL, Vang S, Hedegaard J, Hansen TB, Kjems J, Dyrskjøt L, Pedersen JS. NPJ Genom Med. 2017 validated different circRNAs expressed at various levels RNA-seq, RT-PCR and sanger sequencing T24, FL3, HCV29, RT4 and HT1376 cells, non-muscle-invasive bladder cancer samples circPCMTD1 circRNA homo sapiens PCMTD1 bladder cancer 29263845 Circular RNA expression is abundant and correlated to aggressiveness in early-stage bladder cancer. Okholm TLH, Nielsen MM, Hamilton MP, Christensen LL, Vang S, Hedegaard J, Hansen TB, Kjems J, Dyrskjøt L, Pedersen JS. NPJ Genom Med. 2017 validated different circRNAs expressed at various levels RNA-seq, RT-PCR and sanger sequencing T24, FL3, HCV29, RT4 and HT1376 cells, non-muscle-invasive bladder cancer samples circZMYM4 circRNA homo sapiens ZMYM4 bladder cancer 29263845 Circular RNA expression is abundant and correlated to aggressiveness in early-stage bladder cancer. Okholm TLH, Nielsen MM, Hamilton MP, Christensen LL, Vang S, Hedegaard J, Hansen TB, Kjems J, Dyrskjøt L, Pedersen JS. NPJ Genom Med. 2017 validated different circRNAs expressed at various levels RNA-seq, RT-PCR and sanger sequencing T24, FL3, HCV29, RT4 and HT1376 cells, non-muscle-invasive bladder cancer samples circZNF609 circRNA homo sapiens ZNF609 bladder cancer 29263845 Circular RNA expression is abundant and correlated to aggressiveness in early-stage bladder cancer. Okholm TLH, Nielsen MM, Hamilton MP, Christensen LL, Vang S, Hedegaard J, Hansen TB, Kjems J, Dyrskjøt L, Pedersen JS. NPJ Genom Med. 2017 validated different circRNAs expressed at various levels RNA-seq, RT-PCR and sanger sequencing T24, FL3, HCV29, RT4 and HT1376 cells, non-muscle-invasive bladder cancer samples cANRIL 14-5 circRNA homo sapiens ANRIL 23249747 Circular RNAs are abundant, conserved, and associated with ALU repeats. Jeck WR, Sorrentino JA, Wang K, Slevin MK, Burd CE, Liu J, Marzluff WF, Sharpless NE. RNA. 2013 expressed in Hs68 qRT-PCR telomerized Hs68 human fibroblasts cells cASXL1 circRNA homo sapiens ASXL1 23249747 Circular RNAs are abundant, conserved, and associated with ALU repeats. Jeck WR, Sorrentino JA, Wang K, Slevin MK, Burd CE, Liu J, Marzluff WF, Sharpless NE. RNA. 2013 expressed in Hs68 qRT-PCR telomerized Hs68 human fibroblasts cells cFOXN2 circRNA homo sapiens FOXN2 23249747 Circular RNAs are abundant, conserved, and associated with ALU repeats. Jeck WR, Sorrentino JA, Wang K, Slevin MK, Burd CE, Liu J, Marzluff WF, Sharpless NE. RNA. 2013 expressed in Hs68 qRT-PCR telomerized Hs68 human fibroblasts cells cKIAA0182 circRNA homo sapiens KIAA0182 23249747 Circular RNAs are abundant, conserved, and associated with ALU repeats. Jeck WR, Sorrentino JA, Wang K, Slevin MK, Burd CE, Liu J, Marzluff WF, Sharpless NE. RNA. 2013 expressed in Hs68 qRT-PCR telomerized Hs68 human fibroblasts cells cLPAR1 circRNA homo sapiens LPAR1 23249747 Circular RNAs are abundant, conserved, and associated with ALU repeats. Jeck WR, Sorrentino JA, Wang K, Slevin MK, Burd CE, Liu J, Marzluff WF, Sharpless NE. RNA. 2013 expressed in Hs68 qRT-PCR telomerized Hs68 human fibroblasts cells cMYO9B circRNA homo sapiens MYO9B 23249747 Circular RNAs are abundant, conserved, and associated with ALU repeats. Jeck WR, Sorrentino JA, Wang K, Slevin MK, Burd CE, Liu J, Marzluff WF, Sharpless NE. RNA. 2013 expressed in Hs68 qRT-PCR telomerized Hs68 human fibroblasts cells cZFY circRNA homo sapiens ZFY 23249747 Circular RNAs are abundant, conserved, and associated with ALU repeats. Jeck WR, Sorrentino JA, Wang K, Slevin MK, Burd CE, Liu J, Marzluff WF, Sharpless NE. RNA. 2013 expressed in Hs68 qRT-PCR telomerized Hs68 human fibroblasts cells cHIPK3 circRNA homo sapiens HIPK3 23249747 Circular RNAs are abundant, conserved, and associated with ALU repeats. Jeck WR, Sorrentino JA, Wang K, Slevin MK, Burd CE, Liu J, Marzluff WF, Sharpless NE. RNA. 2013 expressed in Hs68 qRT-PCR, FISH telomerized Hs68 human fibroblasts cells circ-CCT4 circRNA homo sapiens CCT4 Temporal Lobe Epilepsy 29428937 High-Throughput Data of Circular RNA Profiles in Human Temporal Cortex Tissue Reveals Novel Insights into Temporal Lobe Epilepsy. Li J, Lin H, Sun Z, Kong G, Yan X, Wang Y, Wang X, Wen Y, Liu X, Zheng H, Jia M, Shi Z, Xu R, Yang S, Yuan F. Cell Physiol Biochem. 2018 Significantly down-regulated in the Temporal Lobe Epilepsy (TLE) group compared with those in the control group. RNA-seq, qRT-PCR temporal cortices from the control and TLE groups circ-STK17A circRNA homo sapiens STK17A Temporal Lobe Epilepsy 29428937 High-Throughput Data of Circular RNA Profiles in Human Temporal Cortex Tissue Reveals Novel Insights into Temporal Lobe Epilepsy. Li J, Lin H, Sun Z, Kong G, Yan X, Wang Y, Wang X, Wen Y, Liu X, Zheng H, Jia M, Shi Z, Xu R, Yang S, Yuan F. Cell Physiol Biochem. 2018 Significantly down-regulated in the Temporal Lobe Epilepsy (TLE) group compared with those in the control group. RNA-seq, qRT-PCR temporal cortices from the control and TLE groups circ-UBQLN1 circRNA homo sapiens UBQLN1 Temporal Lobe Epilepsy 29428937 High-Throughput Data of Circular RNA Profiles in Human Temporal Cortex Tissue Reveals Novel Insights into Temporal Lobe Epilepsy. Li J, Lin H, Sun Z, Kong G, Yan X, Wang Y, Wang X, Wen Y, Liu X, Zheng H, Jia M, Shi Z, Xu R, Yang S, Yuan F. Cell Physiol Biochem. 2018 Significantly down-regulated in the Temporal Lobe Epilepsy (TLE) group compared with those in the control group. RNA-seq, qRT-PCR temporal cortices from the control and TLE groups circ-USP9Y circRNA homo sapiens USP9Y Temporal Lobe Epilepsy 29428937 High-Throughput Data of Circular RNA Profiles in Human Temporal Cortex Tissue Reveals Novel Insights into Temporal Lobe Epilepsy. Li J, Lin H, Sun Z, Kong G, Yan X, Wang Y, Wang X, Wen Y, Liu X, Zheng H, Jia M, Shi Z, Xu R, Yang S, Yuan F. Cell Physiol Biochem. 2018 Significantly down-regulated in the Temporal Lobe Epilepsy (TLE) group compared with those in the control group. RNA-seq, qRT-PCR temporal cortices from the control and TLE groups circ-STK24 circRNA homo sapiens STK24 Temporal Lobe Epilepsy 29428937 High-Throughput Data of Circular RNA Profiles in Human Temporal Cortex Tissue Reveals Novel Insights into Temporal Lobe Epilepsy. Li J, Lin H, Sun Z, Kong G, Yan X, Wang Y, Wang X, Wen Y, Liu X, Zheng H, Jia M, Shi Z, Xu R, Yang S, Yuan F. Cell Physiol Biochem. 2018 Significantly up-regulated in the Temporal Lobe Epilepsy (TLE) group compared with those in the control group. RNA-seq, qRT-PCR temporal cortices from the control and TLE groups circ-VPS37C circRNA homo sapiens VPS37C Temporal Lobe Epilepsy 29428937 High-Throughput Data of Circular RNA Profiles in Human Temporal Cortex Tissue Reveals Novel Insights into Temporal Lobe Epilepsy. Li J, Lin H, Sun Z, Kong G, Yan X, Wang Y, Wang X, Wen Y, Liu X, Zheng H, Jia M, Shi Z, Xu R, Yang S, Yuan F. Cell Physiol Biochem. 2018 Significantly up-regulated in the Temporal Lobe Epilepsy (TLE) group compared with those in the control group. RNA-seq, qRT-PCR temporal cortices from the control and TLE groups circRNA_000598 circRNA homo sapiens Human Cartilage Degradation of Osteoarthritis 28624198 Emerging Roles of circRNA Related to the Mechanical Stress in Human Cartilage Degradation of Osteoarthritis. Liu Q, Zhang X, Hu X, Yuan L, Cheng J, Jiang Y, Ao Y. Mol Ther Nucleic Acids. 2017 overexpressed in the damaged region compared with the intact region of the cartilage in OA microarray, qRT-PCR the damaged region and the intact region of the cartilage in OA circRNA_101975 circRNA homo sapiens Human Cartilage Degradation of Osteoarthritis 28624198 Emerging Roles of circRNA Related to the Mechanical Stress in Human Cartilage Degradation of Osteoarthritis. Liu Q, Zhang X, Hu X, Yuan L, Cheng J, Jiang Y, Ao Y. Mol Ther Nucleic Acids. 2017 overexpressed in the damaged region compared with the intact region of the cartilage in OA microarray, qRT-PCR the damaged region and the intact region of the cartilage in OA circRNA_103387 circRNA homo sapiens Human Cartilage Degradation of Osteoarthritis 28624198 Emerging Roles of circRNA Related to the Mechanical Stress in Human Cartilage Degradation of Osteoarthritis. Liu Q, Zhang X, Hu X, Yuan L, Cheng J, Jiang Y, Ao Y. Mol Ther Nucleic Acids. 2017 overexpressed in the damaged region compared with the intact region of the cartilage in OA microarray, qRT-PCR the damaged region and the intact region of the cartilage in OA hsa-circRNA11783-2 circRNA homo sapiens coronary artery disease and type 2 diabetes mellitus 28777011 Hsa-circRNA11783-2 in peripheral blood is correlated with coronary artery disease and type 2 diabetes mellitus. Li X, Zhao Z, Jian D, Li W, Tang H, Li M. Diab Vasc Dis Res. 2017 Differentially expressed in all three experimental groups: the control group and the CAD group, the control group and the T2DM group, the control group and the CAD and T2DM group. hsa-circRNA11783-2 was significantly lower in both the T2DM group and CAD group compared with the control group (in the second cohort). Hsa-circRNA11783-2 was downregulated in both the CAD and T2DM groups compared with the control group (in the third cohort), and the corresponding fold changes were 0.4 (p = 0.014) and 0.5 (p < 0.001) in the CAD and T2DM groups, respectively. Logistic regression analysis indicated that the crude OR of hsa-circRNA11783-2 was 0.740 [95% confidence interval (CI) = (0.630¨C0.869), p < 0.001] in the CAD group and 0.778 [(0.659¨C0.919), p = 0.003] in the T2DM group. After introducing the shared risk factors of CAD and T2DM (TC, TG, HDL, LDL, smoking and hypertension), the adjusted OR was 0.688 [(0.571¨C0.829), p < 0.001] in the CAD group and 0.723 [(0.591¨C0.883), p = 0.002] in the T2DM group. microarray, qRT-PCR the peripheral blood of coronary artery disease patients, type 2 diabetes mellitus patients and controls hsa-circRNA11806-28 circRNA homo sapiens coronary artery disease and type 2 diabetes mellitus 28777011 Hsa-circRNA11783-2 in peripheral blood is correlated with coronary artery disease and type 2 diabetes mellitus. Li X, Zhao Z, Jian D, Li W, Tang H, Li M. Diab Vasc Dis Res. 2017 Differentially expressed in all three experimental groups: the control group and the CAD group, the control group and the T2DM group, the control group and the CAD and T2DM group. hsa-circRNA11806-28 was significantly lower in both the T2DM group and CAD group compared with the control group (in the second cohort). microarray, qRT-PCR the peripheral blood of coronary artery disease patients, type 2 diabetes mellitus patients and controls hsa-circRNA6510-1 circRNA homo sapiens coronary artery disease and type 2 diabetes mellitus 28777011 Hsa-circRNA11783-2 in peripheral blood is correlated with coronary artery disease and type 2 diabetes mellitus. Li X, Zhao Z, Jian D, Li W, Tang H, Li M. Diab Vasc Dis Res. 2017 Differentially expressed in all three experimental groups: the control group and the CAD group, the control group and the T2DM group, the control group and the CAD and T2DM group. hsa-circRNA6510-1 was significantly lower in both the T2DM group and CAD group compared with the control group (in the second cohort). microarray, qRT-PCR the peripheral blood of coronary artery disease patients, type 2 diabetes mellitus patients and controls hcircRasGEF1B circRNA homo sapiens 27362560 Inducible RasGEF1B circular RNA is a positive regulator of ICAM-1 in the TLR4/LPS pathway. Ng WL, Marinov GK, Liau ES, Lam YL, Lim YY, Ea CK. RNA Biol. 2016 expression of hcircRasGEF1B in THP-1 cells is induced upon LPS stimulation qRT-PCR THP-1 f-circM9_2 fusion circRNA homo sapiens MLL-AF9 fusion gene GGATTCNGGCCCAGGGGCCGAGACATTCCCTTCTTCACTCTTTTCCTCGACGGGCTTTCGTGGAGGAGGCTCACTACTGCTTTTCTTTGGGGCAGGATCCTCTCTTGCTGATGGGGTAGGTTTCTGACTAGAGTCCACCACGTTCTTCACAACACTGCTCTCTTTGCTGTCTTTCTTTTCACTGGTCTTAGACTTTTTCTCTTTCTTTTTCACAGCTTTAGCTTGCTTCTGCAGGTAGGCTTTGGAAGGCATCCATTGTAGATTCTGACATTTTCTCATCTTGCAGCACTGCTTCTTTATATTGCGACCACCAAACTTGGGCTTATCTAAGCAATTAGTACAAACACCACAGTCCTCAGGCACCTGGCAGCCGGGACACTGCCCACACCGCCTCGATCGACGTCCTTTCTTTACTGGAGGTTCCTGGGGTGCCTTGTTTCTAGTGACAGGTTTAATTGGTTTGATGGGTGGAGCAAGAGGTTCAGCATCTTCTGAGCCAGCAATTGATGACTTGTCTTGTTGCCTGGTCTGGGAT acute myeloid leukemia 27040497 Oncogenic Role of Fusion-circRNAs Derived from Cancer-Associated Chromosomal Translocations. Guarnerio J, Bezzi M, Jeong JC, Paffenholz SV, Berry K, Naldini MM, Lo-Coco F, Tay Y, Beck AH, Pandolfi PP. Cell. 2016 f-circM9_2 is expressed in THP1 cells. PCR products sequencing THP1 cell line, MEFs, HSCs, mouse f-circM exerts tumor promoting activity in immortalized MEFs and is involved in the tumorigenic process independent of their linear transcript and their fusion protein counterparts. f-circM9, when coupled with other oncogenic stimuli (e.g., the presence of the oncogenic fusion protein), plays an active role in favoring leukemia progression in vivo. f-circM9 also provides tumor cells a survival advantage in response to therapy treatment, likely impacting therapeutic outcomes and palys an important role in maintaining the viability of leukemic cells. loss of function, gain of function THP1 cell line, MEFs, HSCs, mouse f-circM9_1 fusion circRNA homo sapiens MLL-AF9 fusion gene CTNTTGGANTCNGGCCCAGGGGCCGAGACATTCCCTTCTTCACTCTTTTCCTCGACGGGCTTTCGTGGAGGAGGCTCACTACTGCTTTTCTTTGGGGCAGGATCCTCTCTTGCTGATGGGGTAGGTTTCTGACTAGAGTCCACCACGTTCTTCACAACACTGCTCTCTTTGCTGTCTTTCTTTTCACTGGTCTTAGACTTTTTCTCTTTCTTTTTCACAGCTTGTTGCCTGGTCTGGGAT acute myeloid leukemia 27040497 Oncogenic Role of Fusion-circRNAs Derived from Cancer-Associated Chromosomal Translocations. Guarnerio J, Bezzi M, Jeong JC, Paffenholz SV, Berry K, Naldini MM, Lo-Coco F, Tay Y, Beck AH, Pandolfi PP. Cell. 2016 f-circM9_1 is expressed in THP1 cells. PCR products sequencing THP1 cell line, MEFs, HSCs, mouse model f-circM exerts tumor promoting activity in immortalized MEFs and is involved in the tumorigenic process independent of their linear transcript and their fusion protein counterparts. f-circM9, when coupled with other oncogenic stimuli (e.g., the presence of the oncogenic fusion protein), plays an active role in favoring leukemia progression in vivo. f-circM9 also provides tumor cells a survival advantage in response to therapy treatment, likely impacting therapeutic outcomes and palys an important role in maintaining the viability of leukemic cells. loss of function, gain of function THP1 cell line, MEFs, HSCs, mouse model cZNF292 circRNA homo sapiens ZNF292 glioma 27613831 Silencing of cZNF292 circular RNA suppresses human glioma tube formation via the Wnt/β-catenin signaling pathway. Yang P, Qiu Z, Jiang Y, Dong L, Yang W, Gu C, Li G, Zhu Y. Oncotarget. 2016 expressed in gliomas cell lines such as U87MG and U251 qRT-PCR U87MG and U251 cZNF292 silencing suppresses tube formation by inhibiting glioma cell proliferation and cell cycle progression. loss of function U87MG and U251 circStau2b circRNA mus musculus Stau2 mmu_circ_0000012 mm9_circ_000040 ATGTTTTCGGTGCAGCTGAGTCTTGGCGAGCAGACATGGGAATCCGAAGGGAGCAGTATAAAGAAGGCCCAACAAGCTGTTGCTAACAAAGCTTTGACTGAATCTACGCTTCCCAAACCAGTTCAGAAACCACCTAAAAGTAATGTCAATAATAACCCAGGTAGTATAACTCCAACTGTGGAACTGAATGGGCTCGCTATGAAAAGGGGAGAGCCTGCCATCTACAGGCCACTAGATCCAAAGCCATTCCCAAATTATAGAGCTAACTACAACTTCCGGGGCATGTACAATCAGAG 25921068 Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed. Rybak-Wolf A, Stottmeister C, Glažar P, Jens M, Pino N, Giusti S, Hanan M, Behm M, Bartok O, Ashwal-Fluss R, Herzog M, Schreyer L, Papavasileiou P, Ivanov A, Ohman M, Refojo D, Kadener S, Rajewsky N. Mol Cell. 2015 Another example is two conserved circRNAs from the RNA-binding protein Staufen 2 gene, which show differential expression among the analyzed tissues. While the longer circRNA isoform (containing exons 2¨C5, circRNA stau2a) is expressed in the majority of adult mouse tissues, the shorter, consisting of exons 4 and 5 (circRNA stau2b), is predominantly expressed in embryonic stem (ES) cells, embryonic tissues, and lung. qRT-PCR, northern blots P19 and SH-SY5Y cells, primary forebrain neurons from CD1 mouse embryos (E17.5¨CE18.5) circStau2a circRNA mus musculus Stau2 mmu_circ_0000013 mm9_circ_006026 TTTTGTGGAGCTGTGAGGGATACGGAAGTTTGATCAATATTGTCTTAACATGCTTCAGATAAATCAGCTTCTCTCCACGATAAAATGGCAAACCCCAAAGAGAAAACTCCAGTGTGTCTGGTAAATGAGTTAGCCCGTTTCCATAGCATCCAACCCCAGTATAAGCTTCTGAATGAAAGCGGGCCTGCTCATTCGAAGATGTTTTCGGTGCAGCTGAGTCTTGGCGAGCAGACATGGGAATCCGAAGGGAGCAGTATAAAGAAGGCCCAACAAGCTGTTGCTAACAAAGCTTTGACTGAATCTACGCTTCCCAAACCAGTTCAGAAACCACCTAAAAGTAATGTCAATAATAACCCAGGTAGTATAACTCCAACTGTGGAACTGAATGGGCTCGCTATGAAAAGGGGAGAGCCTGCCATCTACAGGCCACTAGATCCAAAGCCATTCCCAAATTATAGAGCTAACTACAACTTCCGGGGCATGTACAATCAGAG 25921068 Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed. Rybak-Wolf A, Stottmeister C, Glažar P, Jens M, Pino N, Giusti S, Hanan M, Behm M, Bartok O, Ashwal-Fluss R, Herzog M, Schreyer L, Papavasileiou P, Ivanov A, Ohman M, Refojo D, Kadener S, Rajewsky N. Mol Cell. 2015 Another example is two conserved circRNAs from the RNA-binding protein Staufen 2 gene, which show differential expression among the analyzed tissues. While the longer circRNA isoform (containing exons 2¨C5, circRNA stau2a) is expressed in the majority of adult mouse tissues, the shorter, consisting of exons 4 and 5 (circRNA stau2b), is predominantly expressed in embryonic stem (ES) cells, embryonic tissues, and lung. By northern blots, using probes detecting both linear and circular isoforms, we validated this circRNA to be specifically enriched in the brain, although its linear isoform mostly show much broader expression patterns across tissues. qRT-PCR, northern blots P19 and SH-SY5Y cells, primary forebrain neurons from CD1 mouse embryos (E17.5¨CE18.5) circMfsd6 circRNA mus musculus Mfsd6 mmu_circ_0000037 mm9_circ_009434 ATCACCATTCAGAATTTTGAAGGTCACTGACCCTAATGGTGGTGGTAAGCCATGGCTGCTGATGATAAAGTTGCTATCCTAACTGATGATGAAGAGGAGCAGAAGAGAAAATATGTGCTTGCTGATCCCTTCAATGGCATCTGCAGGGAACCAGAACCACCTTCTAATGAAACCCCCTCCTCCACAGAGACCTCAGCCATTCCCGAGGAGGAAATAGACTGGATAGAGAAACATTGTGTGAAAGTCAACAATGACCTTCTCATCTCCAAGGTGTTTTATTTTTTCTTTTACTCTGCCTATGGCTCTCTTTACCCTCTCTTACCTGTATATTATAAACAGCTGGGAATGTCACCTAGCCAGAGTGGACTGTTGGTGGGCATTCGATACTTCATTGAATTCTGCAGTGCCCCCTTCTGGGGTGTAGTTGCAGATCGTTTCAGAAAGGGCAAAATTGTCCTCCTCTTTTCGCTTCTGTGTTGGGTTTTGTTCAACCTGGGCATTGGATTTGTCAAACCTGCTACCTTGAGATGTCTACCAAAGATCCCCCCAACAGCTCACCCCACCAATGTAAGTCACCCAGTAACTGTTCTGCCAATGAACTCCTCCACTGTCGCTTTCTTTAGCACACCACCAAAATTGCTCCAGAAAAGGGACGTGCAATTGTCTGAAACAGAGCCCAATATCTCAGACATAGATCTCGTGTCAACAGCATTGACCTTGACCAGTGAACCCACACGGAGGCCCCAGACAGAGGCAATTACCCACCCTGTTACAGGCTTGATTTTGAACACAAGCACAGTGACTCTGCCCCCCACAGGAAATGTCACCAGGGAGACAACCATTGCTGTGGTCACCACCACCAAATCTTTACCATCTGATCAAGTCACCCTTGTGTATGACCAACAGGAAGTTGAGGCGATATTCTTAATTATCTTAGTGGTTGTCATAATAGGAGAATTTTTCAGTGCCTCTTCTGTCACGATTGTAGATACAGTAACCCTCCAGTACCTGGGAAAACACCGAGACCGATATGGGCTACAGCGCATGTGGGGCTCCCTGGGCTGGGGCCTGGCCATGCTGTCTGTGGGTATTGGAATCGACTATACTCATATAGATGTGCTCATTGATGGGAAGGGGTGTAAGCCCCCTGAGTACCGGAACTACCAGATTGTCTTCATCGTCTTTGGAGTTCTCATGACCATGGCCCTGATCGTTGCCACTCAGTTCCGGTTCCGCTACAACCACTTCAACAATAGTGATGGTAAAGGGAAAGAGGTGGAGATCCCACAGGTGGAAAGGGACAACTCCACAGAGTCCTCTGAAGAGACTCCAACTGCCGCGACTCACTCACAGGCCTTCAACTTCTGGGACTTGATCAAGTTGCTATGCAGTGTGCAGTATGGCTCGGTTCTGTTTGTGGCCTGGTTCATGGGTTTTGGATACGGCTTCGTGTTCACCTTTCTCTACTGGCATCTGGAAGACCTAAATGGAACTACAACCCTCTTTGGGGTCTGTTCAGTCCTGAGTCATGTGTCCGAGTTGACCGCTTACTTCTTCAGCCACAAGCTTATTGAGTTGATTGGCCATATCAG 25921068 Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed. Rybak-Wolf A, Stottmeister C, Glažar P, Jens M, Pino N, Giusti S, Hanan M, Behm M, Bartok O, Ashwal-Fluss R, Herzog M, Schreyer L, Papavasileiou P, Ivanov A, Ohman M, Refojo D, Kadener S, Rajewsky N. Mol Cell. 2015 We selected several of the circRNAs, which showed a high CLR in at least one differentiation stage, and tested their expression changes with qRT-PCR and northern blots with independent biological replicates. As seen from the sequencing data, many of the analyzed circRNAs increase when linear transcript expression also increases (such as Mfsd6), but rarely by the same factor. qRT-PCR, northern blots P19 and SH-SY5Y cells, primary forebrain neurons from CD1 mouse embryos (E17.5¨CE18.5) circCpsf6 circRNA mus musculus Cpsf6 mmu_circ_0000215 mm9_circ_008959 GAAGCAGAATATGGTGGACATGATCAGATAGATTTGTATGATGATGTCATCTCTCCATCTGCAAATAATGGCGATGCCCCAGAAGATCGCGACTACATGGATACTCTTCCACCAACTGTTGGTGATGATGTGGGTAAAGGAGCCGCACCAAACGTTGTGTACACTTACACTGGGAAGAGAATCGCATTGTATATTGGAAATCTAACATGGTGGACAACAGATGAGGACCTAACTGAGGCCGTTCATTCTTTGGGAGTAAATGATATTTTGGAGATAAAATTCTTTGAAAATCGGGCAAATGGACAATCAAAGGGATTTGCCCTTGTTGGTGTTGGATCTGAAGCATCTTCCAAAAAGTTAATGGATCTTTTGCCTAAAAGAGAACTTCATGGTCAGAGTCCTGTTGTAACTCCATGCAATAAGCAGTTCCTGAGTCAATTTGAAATGCAATCCAGGAAAACTACACAGTCAGGACAGATGTCTGGGGAAGGGAAAGCCGGTCCTCCAGGAGGCGGTTCACGCGCAGCGTTTCCTCAAGGTGGTAGAGGACGGGGCCGGTTTCCAGGGGCTGTTCCTGGTGGGGACAGATTTCCTGGGCCAGCAGGACCAGGAGGGCCACCTCCACCTTTTCCAGCTGGACAAACTCCACCACGTCCACCTTTAGGCCCACCTGGCCCACCTGGTCCACCAGGTCCTCCACCTCCTGGTCAGGTTCTGCCACCTCCTCTAGCAGGACCTCCTAACCGAGGAGACCGCCCTCCACCACCAGTTCTTTTTCCTGGACAACCTTTTGGGCAGCCTCCGCTGGGTCCACTTCCTCCTGGGCCTCCACCTCCAGTTCCAGGCTACGGCCCCCCTCCAGGTCCACCGCCTCCACAGCAGGGACCACCTCCACCTCCAGGCCCCTTTCCACCTCGCCCACCAGGTCCACTAGGGCCTCCCCTCACACTTGCTCCTCCTCCACATCTTCCGGGACCACCTCCAGGTGCCCCGCCACCAGCTCCACATGTGAATCCTGCTTTTTTTCCTCCACCAACTAATAGTGGCATGCCAACATCAGATAGTCGAGGTCCACCACCAACAGACCCATATGGCCGACCTCCCCCATATGATAGGGGTGACTACGGTCCCCCTGGGAGGGAAATGGATACTGCAAGAACACCTCTGAGTGAAGCTGAGTTTGAAGAAATCATGAATAGAAATCGGGCAATCTCAAGCAGTGCTATTTCAAGAGCTGTGTCTGACGCTAGTGCTGGTGATTATGGGAGTGCTATTGAAACATTGGTAACAGCAATTTCTTTAATTAAACAATCCAAAGTCTCTGCAGATGATCGTTGCAAAGTTCTTATTAGCTCTCTGCAGGATTGCCTTCATGGAATCGAGTCCAAGTCCTATGGGTCTGGATCCAGACGTGAACGATCAAGAGAACGGGACCATAGTAGATCACGGGAAAAGAGTCGTCGCCATAAATCTCGGAGTAGAGATCGCCACGATGACTATTACAGAGAGAGAAGCAGAGAACGAGAGAGACACCGGGATCGGGACCGCGACCGTGACCGAGAGCGTGACCGAGAGCGAGAATACCGTCATCGTTAGAAG 25921068 Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed. Rybak-Wolf A, Stottmeister C, Glažar P, Jens M, Pino N, Giusti S, Hanan M, Behm M, Bartok O, Ashwal-Fluss R, Herzog M, Schreyer L, Papavasileiou P, Ivanov A, Ohman M, Refojo D, Kadener S, Rajewsky N. Mol Cell. 2015 By northern blots, using probes detecting both linear and circular isoforms, we validated this circRNA to be specifically enriched in the brain, although its linear isoform mostly show much broader expression patterns across tissues. qRT-PCR, northern blots P19 and SH-SY5Y cells, primary forebrain neurons from CD1 mouse embryos (E17.5¨CE18.5) mmu_circHECTD1 circRNA mus musculus Hectd1 mmu_circ_0000375 mm9_circ_002888 GAAGAAGAAGAGTATGAAACCAAAGGAGGCCGCCGCAGAGCCTGGGATGACGACTATGTGCTAAAGCGCCAGTTTTCTGCACTGGTCCCTGCTTTTGATCCTAGACCTGGTCGTACCAATGTCCAGCAGACAACTGACCTAGAAATTCCTCCCCCAGGAACACCTCACTCAGAGCTCTTGGAGGAAGTTGAATGTACTCCGTCACCTCGCTTGGCTCTCACACTGAAAGTGACGGGGCTTGGAACAACGCGGGAAGTTGAACTGCCACTTACCAATTTCAGATCCACCATCTTTTACTATGTACAAAAACTGCTTCAACTGTCTTGTAATGGCAATGTGAAGTCAGATAAACTTAGGCGTATTTGGGAGCCCACTTACAC silicosis 29290828 circRNA Mediates Silica-Induced Macrophage Activation Via HECTD1/ZC3H12A-Dependent Ubiquitination. Zhou Z, Jiang R, Yang X, Guo H, Fang S, Zhang Y, Cheng Y, Wang J, Yao H, Chao J. Theranostics. 2018 mmu_circHECTD1 expression varied in the lungs of mice in the NS group and SiO2 group. mmu_circHECTD1 expression decreased after 24 h of SiO2 exposure in RAW264.7 cells. These results were confirmed in a fluorescence in situ hybridization (FISH) assay, in which mmu_circHECTD1 was mainly detected in the cytoplasm of RAW264.7 cells. mmu_circHECTD1 was significantly decreased after 7 and 28 days compared with the levels in NS-treated mice. microarray, qRT-PCR, FISH the lungs of mice, RAW264.7 cells SiO2 concomitantly decreased circHECTD1 levels and increased HECTD1 protein expression. circHECTD1 and HECTD1 were involved in SiO2-induced macrophage activation via ubiquitination; and SiO2-activated macrophages promoted fibroblast proliferation and migration via the circHECTD1/HECTD1 pathway. Tissue samples from silicosis patients confirmed the upregulation of HECTD1. loss of function, gain of function RAW264.7 cells, mouse lungs Human bronchoalveolar lavage fluid of patients with silicosis ZC3H12A circRNA-protein RAW264.7 cells RIP ZC3H12A interacted with circHECTD1 but not HECTD1 mRNA. circHECTD1 circRNA mus musculus Hectd1 mmu_circ_0000375 mm9_circ_002888 GAAGAAGAAGAGTATGAAACCAAAGGAGGCCGCCGCAGAGCCTGGGATGACGACTATGTGCTAAAGCGCCAGTTTTCTGCACTGGTCCCTGCTTTTGATCCTAGACCTGGTCGTACCAATGTCCAGCAGACAACTGACCTAGAAATTCCTCCCCCAGGAACACCTCACTCAGAGCTCTTGGAGGAAGTTGAATGTACTCCGTCACCTCGCTTGGCTCTCACACTGAAAGTGACGGGGCTTGGAACAACGCGGGAAGTTGAACTGCCACTTACCAATTTCAGATCCACCATCTTTTACTATGTACAAAAACTGCTTCAACTGTCTTGTAATGGCAATGTGAAGTCAGATAAACTTAGGCGTATTTGGGAGCCCACTTACAC pulmonary silicosis 29540674 circHECTD1 promotes the silica-induced pulmonary endothelial-mesenchymal transition via HECTD1. Fang S, Guo H, Cheng Y, Zhou Z, Zhang W, Han B, Luo W, Wang J, Xie W, Chao J. Cell Death Dis. 2018 SiO2 induced a rapid increase in circHECTD1 expression in MML1 cells, which was confirmed using FISH. Moreover, SiO2 also induced circHECTD1 expression in human endothelial cell line-HUVECs. qRT-PCR, FISH MML1 cells, human endothelial cell line-HUVECs SiO2 concomitantly increased circHECTD1 expression, which, in turn, inhibited HECTD1 protein expression. SiO2-induced increases in cell proliferation, migration, and changes in marker levels were restored by either a small interfering RNA (siRNA) targeting circHECTD1 or overexpression of HECTD1 via the CRISPR/Cas9 system, confirming the involvement of the circHECTD1/HECTD1 pathway in the EndMT. loss of function MML1 Tie2-GFP mice exposed to SiO2 and silicosis patients silicosis patients circMyst4 circRNA mus musculus Myst4 mmu_circ_0000505 mm9_circ_008231 GTCTTGGTTTCCTAAAGATGTCTTTCACTTGAAGAGTGCAGTCCTTCCCATTGGTGAACTAAGACAACTCTCCACGTTGCCTGGCAGTCAGTCCTCTCTTTAAGGATGGTTGTCCCTATGCTGTTGCTTCACATGGGCTGGGATCCTCTGCCCTTGTGTTGAATTGTGACTTTGGAATGTGCAGGTTGTGTTAAGTACAAGGCGAATCTCTATGGGTAACGTCTGTGTTGGAGAAGCCATTTGTCAACCATGGTAAAACTTGCAAACCCACTTTACACAGAGTGGATTCTTGAAGCAGTGCAGAAAATCAAGAAGCAGAAGCAGCGGCCCTCAGAAGAGAGGATCTGCCATGCGGTCAGCACGTCCCATGGGTTGGACAAGAAAACAGTCTCGGAACAGCTGGAACTTAGTGTTCAGGATGGCTCCGTTCTCAAAGTCACCAACAAAGGCCTTGCTTCATATAAGGACCCAGACAATCCTGGGCGTTTTTCATCGGTTAAACCGGGCACTTTCCCCAAGCCAACCAAGGGGTCCAAAGGACCGCCGTGTAATGATCTACGCAATGTGGATTGGAATAAACTTTTAAAGAGAGCAATCGAAGGCCTTGAGGAGCCAAACGGCTCCTCCTTGAAGAACATTGAGAAGTATCTGAGAAGCCAGAGTGATCTTACAGGCACCACCAACCATCCAGCCTTTCAGCAGAGGTTGCGGCTAGGGGCCAAGCGTGCTGTGAACAATGGGAGGTTACTGAAGGAAGGACCACAGTACAGGGTCAATAGTGGGAGCTCAGATGGCAAAGGGGCGCCCCAGTACCCCAGTGCTTTTCCGTCCTCACTCCCGCCCGTCAGCCTTCTACCCCATGAGAAAGACCAG 25921068 Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed. Rybak-Wolf A, Stottmeister C, Glažar P, Jens M, Pino N, Giusti S, Hanan M, Behm M, Bartok O, Ashwal-Fluss R, Herzog M, Schreyer L, Papavasileiou P, Ivanov A, Ohman M, Refojo D, Kadener S, Rajewsky N. Mol Cell. 2015 Numerous circRNAs were found as the predominant isoform in brain, such as circMyst4. qRT-PCR, northern blots P19 and SH-SY5Y cells, primary forebrain neurons from CD1 mouse embryos (E17.5¨CE18.5) circRims2 circRNA mus musculus Rims2 mmu_circ_0000595 mm9_circ_011266 GTGCTATGGATATAGAGGAGAGAAATCGCCAAATGAAACTTAACAAATACAAACAGGTAGCCGGATCAGACCCCAGACTGGAGCAAGATTACCATTCGAAGTATCGCTCAGGATGGGATCCACATAGAGGGGCAGATACTGTTTCCACTAAATCCTCGGACAGTGATGTAAGTGATGTATCTGCGGTTTCAAGGACTAGTAGTGCTTCTCGTTTCAGCAGCACAAGCTACATGTCCGTCCAATCAGAGCGGCCGAGAGGAAACAGGAAAATCAGTGTCTTTACATCCAAAATGCAAAACAGACAGATGGGCGTGTCGGGGAAGAACTTGACCAAAAGCACCAGCATCAGTGGAGACATGTGCTCACTGGAGAAGAATGACGGCAGCCAGTCCGACACTGCAGTGGGCGCCCTGGGTACCAGTGGCAAGAAGCGGCGATCTAGCATTGGGGCCAAAATGGTAGCTATTGTTGGTCTCTCACGGAAAAGTCGCAGTGCCTCTCAACTCAGCCAAACCG 25921068 Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed. Rybak-Wolf A, Stottmeister C, Glažar P, Jens M, Pino N, Giusti S, Hanan M, Behm M, Bartok O, Ashwal-Fluss R, Herzog M, Schreyer L, Papavasileiou P, Ivanov A, Ohman M, Refojo D, Kadener S, Rajewsky N. Mol Cell. 2015 A striking example is the mouse circRNA generated from Rims2. In the adult brain, it is expressed 20-fold higher than the linear mRNA, but is lowly expressed in other mouse tissues. By northern blots, using probes detecting both linear and circular isoforms, we validated this circRNA to be specifically enriched in the brain, although its linear isoform mostly show much broader expression patterns across tissues. We found several circRNAs enriched in specific brain regions¡ªindependent of their linear isoforms. Some circRNAs were highly enriched in the cerebellum: circRims2, circElf2, and circDym, while circPlxnd1 was enriched in the cortex. circRims2 was detected exclusively in the granular layer of the cerebellum. qRT-PCR, northern blots P19 and SH-SY5Y cells, primary forebrain neurons from CD1 mouse embryos (E17.5¨CE18.5) circTulp4 circRNA mus musculus Tulp4 mmu_circ_0000723 mm9_circ_008009 AGTTGTAAGAGTCCATCCAGGACCTTCCAGTCATGAATAATCTGATGGCTCCTGAATTAACCGGGAAAACAAACATATCAAGTGCCATTTGAAGACTCTGTCTATCTATGTAAAACCTTTTCTGCACATAGAAGCTTTTCCATAAGAAGACATTCTGAATTTTGCAACTGATGAAGATTAAGCATCAGCTGGAGCACCTTTCCACTGTTGGGGTTGGGAGTCTGTGGAGAACAGTCTGTCACTAATGTCAGATTTTCCTTACAGTGTTCATAAACAAAAGCCAGTTTGCAAAAGAAAAAATTGCACAGATTAACCCTAAAGAATAGCTCCAGTGTAAAGCAGGGGCAGACCTTAAAACTCTGAACCGGAGCTCAGTGACTTTTCCTGTGGTTGTAGCAGGAGTGAGGGGACTGATCTGAAAGGAACAGATTCCTTTGTGTCTTCAGCTATCGGAAGTTTTTTATTTATTGTTTATCTTTTTTCTTTTCTGCATATATATGCCATTTTAAAATACTAATTGGAACTGTCAGTTACAAAATAAATATCAAGAAAAGCCTTTTTTGGTCCAAAGGTGTGAACAGGCTTGCAGGTGAACAGGAAGACATCTTTGGTAAAGCTTGGACCGGTCTTGGGAGATGGTGCATCTTGGAGGGCTCTGCTACACGCCTAGGTGGCTGGTTTAAAGGCTTGCATCGCAGACGGAGACTAATTAATAGACACAGTTCTAAGATTGCTTTTTCATTAACATAGAAACTAGAGAAAGGAGAAACAGAAGCCTGCAGCCTAGTCTGTGTAAGCAAGAAGTAGGACCAAACTGAGGAAACTACTTGGTCCATTTAGATAGCAGTTTATTCATACTCAGTGACCCGCAGGCCTCCACCTCTGCTTGAGGGAAGGGCTTTGCTCCAGTCTCTGTGGCACTGAGGGTGGTTCCAGCCCATGGAGGAGTCATTCTAGGAAGCCCTGTGTTCCTAGGGACACAGGGCCAGGCTTTGAGACAGGAAGCTTCTGGCTGTGAGCAGTGGGGGAAAGAGTGATTTTCTTGTTAAAGCTTTGACCATTGTCTGCATGAGCTCTGGTGTGACTTTGCACGTTAGTGTGCCTTTCCCCTTATGCAACCTTTTCCAGCTTACAGCAGAAACTTGCCGAGTTCAGAAAACGTGCCAGAGGGTGGCTTCAGAGGGAAGATGATCTTGTGTGATCAGTCTCTGCACTTGAACTATTGAATAGAGAAATCCAGCTAGAGGAATTCTTACCGCCTTAAGTTACTTGAAATCTATGTGTTTGTAACCCTTTGTCTCTGGAATTACATTACAAAAAAAACTGGAATCTCAGGCTGAGAATAACGAGGCTGAGTAAAAGCGAAGAGAACTGCCTCTTCATCATCACTTACTAACAGCTCTTTCTCCAAAGGATTGGTGTGGTTTCCCGCTAAGAACTTGAAAATGAGAACGGACCCTGTGTATTTTTAGGCATTACCTTTCTTCGCCGACTGACGTCTTTTATAGAGGAGTTTTTTCACTATGCATTTGGTGGAGCTTTATAAGCTATTGACCTAATTGGACTCTAGATCAGTTGTAACTAAAGGAGAAAAAAACAAACCAACGGAACCCAACCACAAAAATAAGCCAATAAAAGAACTTGGTTTGAAATTCCTCAGTACTTTTAAAGTGAAATACTTCATTGAAAAAAGTATGTATGCAGCAGTGGAACATGGGCCTGTGCTTTGCAGCGATTCCAACATCCTCTGCCTGTCCTGGAAGGGGCGTGTTCCCAAGAGTGAGAAGGAGAAACCTGTGTGCAGAAGGCGCTACTATGAAGAGGGATGGTTGGCCACAGGCAATGGGCGAGGTGTGGTGGGAGTGACTTTCACCTCGAGTCACTGTCGCAGAGATAGGAGTACACCACAGAGAATAAACTTCAACCTGCGAGGCCACAACAGTGAG 25921068 Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed. Rybak-Wolf A, Stottmeister C, Glažar P, Jens M, Pino N, Giusti S, Hanan M, Behm M, Bartok O, Ashwal-Fluss R, Herzog M, Schreyer L, Papavasileiou P, Ivanov A, Ohman M, Refojo D, Kadener S, Rajewsky N. Mol Cell. 2015 Numerous circRNAs were found as the predominant isoform in brain, such as circTulp4. qRT-PCR, northern blots P19 and SH-SY5Y cells, primary forebrain neurons from CD1 mouse embryos (E17.5¨CE18.5) circVim circRNA mus musculus Vim mmu_circ_0000978 mm9_circ_016723 ACATGGCTTCGAAGGTGGGCTGGCTTGCTGCGGCTGGAAAAACTGCAACAAGGGAATGAGGGCGCGGTGGCTGTGAATCGTAGGAGCGCTGGGGTCTCTGGG 25921068 Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed. Rybak-Wolf A, Stottmeister C, Glažar P, Jens M, Pino N, Giusti S, Hanan M, Behm M, Bartok O, Ashwal-Fluss R, Herzog M, Schreyer L, Papavasileiou P, Ivanov A, Ohman M, Refojo D, Kadener S, Rajewsky N. Mol Cell. 2015 circVim was validated experimentally. qRT-PCR, northern blots P19 and SH-SY5Y cells, primary forebrain neurons from CD1 mouse embryos (E17.5¨CE18.5) mmu_circ_0001028 circRNA mus musculus Stk39 mmu_circ_0001028 mm9_circ_017329 GCAGCGGAGCAACTGCGGTGGTTCAGGCAGCCCTATGCAAACCCAGGCAAGAACGCGTAGCCATAAAGCGGATCAACTTGGAAAAATGCCAGACGAGTATGGATGAACTCCTGAAAGAAATTCAAGCCATGAGCCAATGCAGCCATCCCAACGTAGTGACTTATTACACCTCCTTTGTGGTCAAAGATGAGCTGTGGCTGGTCATGAAATTACTAAGTGGAGGTTCCATGTTGGATATCATCAAATACATCGTTAATCGAGGAGAACATAAAAATGGTGTCCTAGAAGAGGCGATAATTGCAACAATTCTTAAGGAGGTTTTGGAAGGTTTAGACTATCTGCACAGAAACGGTCAGATCCATAGGGATTTGAAAGCTGGAAATATTCTTCTGGGTGAGGATGGCTCAGTACAAATAGCAG pulmonary toxicity induced by radon 29165116 Circular RNA profiles in mouse lung tissue induced by radon. Pei W, Tao L, Zhang LW, Zhang S, Cao J, Jiao Y, Tong J, Nie J. Environ Health Prev Med. 2017 The expressions of the circRNA was examined in mice of 60 WLM group. microarray, qRT-PCR BALB/c mice lung tissue circPhf21a circRNA mus musculus Phf21a mmu_circ_0001047 mm9_circ_006097 GGGACTGGAGAGCTGAAGGAGCGCCAGCTTCTCCAGAATTGGACTTCTCAGAACCTTTAATATGCTAATGTGCATTGTGAATCTCCAAGATGGGGATATGATATGCAGCATTCTTGAATACTTCTAATGACAGGGAGCCCACTACCTCATAAGCTGCAGCAACAAGAGGAGCTTGTAATTTTAAACGGAGGCTGAAGACACTGTAGAATTAGCAGACATAAGAGAGCGTGGAGAAGGCAGAGGATGGAGTTGCAGACTCTACAGGAGGCTCTTAAAGTGGAAATTCAGGTTCACCAGAAACTGGTTGCCCAAATGAAGCAGGATCCACAGAATGCTGACTTAAAGAAACAGCTTCATGAACTCCAAGCCAAAATCACAGCTTTGAGTGAGAAACAG 25921068 Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed. Rybak-Wolf A, Stottmeister C, Glažar P, Jens M, Pino N, Giusti S, Hanan M, Behm M, Bartok O, Ashwal-Fluss R, Herzog M, Schreyer L, Papavasileiou P, Ivanov A, Ohman M, Refojo D, Kadener S, Rajewsky N. Mol Cell. 2015 By northern blots, using probes detecting both linear and circular isoforms, we validated this circRNA to be specifically enriched in the brain, although its linear isoform mostly show much broader expression patterns across tissues. circElf2 and circPhf21a showed predominant expression in the granular layer of cerebellum and olfactory bulb, consistent with qRT-PCR and northern blot analysis qRT-PCR, northern blots P19 and SH-SY5Y cells, primary forebrain neurons from CD1 mouse embryos (E17.5¨CE18.5) circDLGAP4 circRNA mus musculus Dlgap4 mmu_circ_0001098 mm9_circ_015028 GTTCATCATGCCTAGTGGCATATAAGAAGACCCCACCACCGGTCCCTCCACGAACCACATCGAAACCGTTCATCTCAGTCACCGTCCAGAGCAGTACTGAGTCTGCTCAGGATACCTACCTGGACAGTCAAGACCACAAGAGCGAAGTGACGAGCCAGTCGGGCTTGAGCAACTCATCAGACAGCCTGGACAGCAGTACCCGGCCACCCAGTGTGACACGGGGTGGAATTACCCCAGGCCCTGAAGCTCCGGAGCCACCCCCTAAGCATGCAGCTCTGAAGAGTGAACAAGGGACACTGACGAGCTCTGAGTCCCATTCCGAGGCCATCCCCAAAAGGAAACTGTCATCGATAGGAATACAAGTTGACTGCATTCAGCCAGTGCCAAAAGAGGAGCCCAGTCCCGCTACCAAATTCCAGTCCATCGGGATTCAGGTAGAGGACGACTGGCGAAGCAGTGCCCCCTCTCACAGCATGTCCTCCCGTCGGGACACTGACTCTGATACCCAGGATGCCAACGACTCCAGTTGTAAGTCATCTGAGAGGAGTCTCCCAGACTGTACCTCACACCCCAATTCCATCAGCATTGATGCTGGCCCCCGACAGGCCCCCAAGATTGCCCAGATCAAGCGCAACCTCTCCTATGGAGACAACAGCGACCCTGCCCTGGAGGCGTCTTCGCTGCCCCCACCCGACCCTTGGCTGGAGACTTCCTCCAGCTCCCCAGCAGAGCCCGCTCAGCCAGGGGCCTGCCGCAGGGATGGCTACTGGTTCCTGAAGCTCCTTCAGGCAGAAACGGAGAGACTGGAAGGCTGGTGCTGCCAGATGGACAAGGAGACCAAAGAGAACAACCTCTCTGAAGAAG acute ischemic stroke 29114076 Circular RNA DLGAP4 Ameliorates Ischemic Stroke Outcomes by Targeting miR-143 to Regulate Endothelial-Mesenchymal Transition Associated with Blood-Brain Barrier Integrity. Bai Y, Zhang Y, Han B, Yang L, Chen X, Huang R, Wu F, Chao J, Liu P, Hu G, Zhang JH, Yao H. J Neurosci. 2018 circDLGAP4 levels in these AIS subjects were significantly decreased compared with those in age- and gender-matched cognitively healthy controls. There were no gender-based differences in circDLGAP4 levels. Consistent with these clinical findings, circDLGAP4 expression levels were observed to be decreased in the ipsilateral hemispheres of mice with tMCAO compared with those in the sham group at 24 h after reperfusion. This was further confirmed by Northern blotting. qRT-PCR, northern blots healthy controls and AIS patients, brain tissues of tMCAO mice circRNA DLGAP4 (circDLGAP4) functions as an endogenous microRNA-143 (miR-143) sponge to inhibit miR-143 activity, resulting in the inhibition of homologous to the E6-APC-terminal domain E3 ubiquitin protein ligase 1 expression. Upregulation of circDLGAP4 expression significantly attenuated neurological deficits and decreased infarct areas and blood¨Cbrain barrier damage in the transient middle cerebral artery occlusion mouse stroke model. Endothelial-mesenchymal transition contributes to blood¨Cbrain barrier disruption and circDLGAP4 overexpression significantly inhibited endothelial-mesenchymal transition by regulating tight junction protein and mesenchymal cell marker expression. gain of function HEK293T, bEnd.3 tMCAO mice healthy controls and AIS patients miR-143 circRNA-miRNA HEK293T, bEnd.3 RNA pull-down, FISH More circDLGAP4 enrichment was detected in the miR-143-captured fraction than in the fractions in which mutations disrupted base-pairing between circDLGAP4 and miR-143 in both HEK293T and bEnd.3 cells. This finding was further confirmed via FISH, demonstrated by colocalization between circDLGAP4 and miR-143 in cytoplasm. HECTD1 circElf2 circRNA mus musculus Elf2 mmu_circ_0001125 mm9_circ_005039 TAGTTCCAGAGAACCTGCTGGTTTAGAGTTTAGCTCTTGGGAGTTGTGAAAACAGTGAAGGATGCTTAGACTACTTAACATTCAAACTACCCTCTGGTTAATCACCTTTAGAAGACTGGACTTCCGGATGTCTACTCCATCTCTATTGAACTAAACCATGAAAATGAAGGCTACAGTCCTGGCAATCGTCTGTGAGCCTTAGTTCCGTTGCTTCACAGCATTTGAGACTTCCTCAGGGAACGCACGATGGCATCGGCGGTGGTTGACAGCGGAGGCTCTGCTCTGGAGCTTCCTAGCGATGGAGGAGAAAATCAAGAGGGAGGTGACACGGGCCCTGACTGCCCGGCAGTGATTGTGGAGCCAGTTCCCAGTGCGAGGTTAGAGCAGGGCTATGCTGCCCAGGTGCTGGTCTATGACGACGAGACTTATATGATGCAGGATGTGGCGGAAGAACAGGAAGTTGAGACGGAGAATTCAGAAACAG 25921068 Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed. Rybak-Wolf A, Stottmeister C, Glažar P, Jens M, Pino N, Giusti S, Hanan M, Behm M, Bartok O, Ashwal-Fluss R, Herzog M, Schreyer L, Papavasileiou P, Ivanov A, Ohman M, Refojo D, Kadener S, Rajewsky N. Mol Cell. 2015 By northern blots, using probes detecting both linear and circular isoforms, we validated this circRNA to be specifically enriched in the brain, although its linear isoform mostly show much broader expression patterns across tissues. We found several circRNAs enriched in specific brain regions¡ªindependent of their linear isoforms. Some circRNAs were highly enriched in the cerebellum: circRims2, circElf2, and circDym, while circPlxnd1 was enriched in the cortex. CircElf2 and circPhf21a showed predominant expression in the granular layer of cerebellum and olfactory bulb, consistent with qRT-PCR and northern blot analysis. qRT-PCR, northern blots P19 and SH-SY5Y cells, primary forebrain neurons from CD1 mouse embryos (E17.5¨CE18.5) mmu_circ_0001152 circRNA mus musculus Fam46c mmu_circ_0001152 mm9_circ_006065 CTGTCTAGGGGCCGCAGTCTCCGCTCCGCTCCTGCTGGGGGCTGCCCACGCCAACCACCTGCCTCAGTCACCTCCTCTTCCAACGCCCAG pulmonary toxicity induced by radon 29165116 Circular RNA profiles in mouse lung tissue induced by radon. Pei W, Tao L, Zhang LW, Zhang S, Cao J, Jiao Y, Tong J, Nie J. Environ Health Prev Med. 2017 The expressions of the circRNA was examined in mice of 60 WLM group. microarray, qRT-PCR BALB/c mice lung tissue mmu_circ_0001154 circRNA mus musculus Cept1 mmu_circ_0001154 mm9_circ_007135 CCCCCAGGTAAATAGCCACAGAAGGCTACCAAACAAGATAAATAATTGTCTCCAAGTAGAAGAAAACCAAGCTCCATGAGTGGGCATCGGTCAACAAGGAAACGATGTGGAGATTCTCACCCAGAGTCCCCTGTGGGCTTTGGGCATATGAGTACTACAGGGTGTGTATTAAATAAATTGTTTCAGTTACCGACACCACCACTGTCAAGACACCAGTTAAAACGGCTAGAAGAACACAGGTATCAGAGTGCTGGACGGTCCCTTCTCGAGCCCTTAATGCAAGGATACTGGGAATGGCTAGTTGGAAGAGTACCCTCATGGATTGCCCCAAATCTCATCACCATCATTGGACTATCAATAAATATCTGTACAACTATTTTGTTAGTCTTCTACTGCCCTACAGCTACAGAGCAGGCACCTCTGTGGGCTTATATTGCCTGTGCTTGTGGCCTTTTCATTTACCAGTCTCTGGATGCCATAGATGGGAAACAGGCCAGAAGAACTAACAGTAGCTCTCCTCTGGGAGAACTTTTTGATCATGGCTGTGACTCACTATCGACAGTTTTTGTGGTTCTTGGAACTTGTATTGCAGTACAACTTGGGACAAATCCTGACTGGATGTTTTTTTGTTGTTTTGCTGGGACATTCATGTTCTATTGTGCACACTGGCAAACATATGTTTCTGGAACATTGCGATTTGGAAT pulmonary toxicity induced by radon 29165116 Circular RNA profiles in mouse lung tissue induced by radon. Pei W, Tao L, Zhang LW, Zhang S, Cao J, Jiao Y, Tong J, Nie J. Environ Health Prev Med. 2017 The expressions of the circRNA was examined in mice of 60 WLM group. microarray, qRT-PCR BALB/c mice lung tissue mmu_circ_0001311 circRNA mus musculus Ankib1 mmu_circ_0001311 mm9_circ_000903 AATGTGAAACATGTTGTAGAAGTACTCAAGAAGTGGCTGAAGGAAGAAAGAACGTGCCACTGCCTATCAGAAAATAACAAAACATGGGAAATACAACCACCAAATTCCGCAAAGCACTCATCAATGGTGATGAAAATTTGGCCTGCCAAATATATGAAAATAATCCTCAGCTAAAAGAATCCCTTGATCCCAATATTTCTTATGGAGAACCCTATCAGCACAACACACCGTTACACTATGCTGCTAGACATGGAATGAATAGAATATTAGGGACTTTTCTTTTTGGTAGAGATGGAAACCCAAATAAACGGAATGTGCACAATGAAACATCTATGCATTTGTTGTGTATGGGACCTCAAATCATGATATCTGAAGGAACCCTTCATCCTCGCTTAGCACGGCCTGTGGAAGATGATTTCAGAAGGGCAGATTGTCTGCAGATGATCTTACAGTGGAAAGGAGCAAAACTTGACCAAGGCGAATATGAGAGAGCGGCTATTGATGCCGTTGATAACAAAAAGAACACACCCCTTCACTATGCTGCAGCCTCGGGGATGAAAGCCTGTGTAGAGCTCTTAGTAAAACATGGAGGAGACTTGTTTGCTGAAAATGAAAATAGAGATACTCCTTGTGATTGTGCCGAAAAGCAGCAGCACAAAGACCTGGCCCTCAGTCTGGAGTCTCAGATGGTGTTCTCTCGGGACCCGGAGGCCGAAGAAATAGAAGCGGAGTATGCTGCCTTAGACAAGCGAGAGCCATATGAAGGACTAAGGCCCCAGGATCTTCGTAGGTTAAAAGATATGCTTATTGTGGAGACTGCAGACATGCTCCAGGCCCCTCTGTTTACTGCTGAAGCACTGCTTCGAGCTCACG pulmonary toxicity induced by radon 29165116 Circular RNA profiles in mouse lung tissue induced by radon. Pei W, Tao L, Zhang LW, Zhang S, Cao J, Jiao Y, Tong J, Nie J. Environ Health Prev Med. 2017 The expressions of the circRNA was examined in mice of 60 WLM group. microarray, qRT-PCR BALB/c mice lung tissue mcircRasGEF1B circRNA mus musculus Rasgef1b mmu_circ_0001367 mm9_circ_015601 GAAAGTATGCCTCAGACGCCCCCCTTCTCAGCAATGTTTGACAGCAGTGGCTACAACCGAAACCTCTACCAGTCCGCAGAGGACAGCTGTGGAGGCTTGTACTACCATGACAACAACCTCCTTTCTGGGTCTCTGGAAGCCCTTATCCAACACTTGGTACCCAATGTGGATTACTATCCTGATAGGACATACATCTTCACCTTCCTGCTTAGTTCTCGGTTATTCATGCATCCGTACGAGCTCATGGCTAAGGTTTGCCACCTGTGTGTTGAGCACCAGCGACTGAGTGAAGGGGACGGCGATAAGAACCAGATGAGAAAAATTGCACCTAAAATCCTTCAGCTCTTGACAGAGTGGACAGAAACATTTCCGTATGACTTCCGGGACGAGAGAATGATGAGGAACCTCAAGGACCTGGCGCACAGGATGGCCAGTGGCGAGGAG microbial infections 28947785 Transcriptomic analysis of the role of RasGEF1B circular RNA in the TLR4/LPS pathway. Ng WL, Marinov GK, Chin YM, Lim YY, Ea CK. Sci Rep. 2017 Knockdown of mcircRasGEF1B results in altered expression of a wide array of genes. Pathway analysis revealed an overall enrichment of genes involved in cell cycle progression, mitotic division, active metabolism, and of particular interest, NF-¦ÊB, LPS signaling pathways, and macrophage activation. These findings expand the set of functionally characterized circRNAs and support the regulatory role of mcircRasGEF1B in immune response during macrophage activation and protection against microbial infections. loss of function RAW264.7 cells circSv2b circRNA mus musculus Sv2b mmu_circ_0001583 mm9_circ_005710 GCTGGGGCTTCAGCATGGGGACTAATTACCACTTCCACAGCTGGAGAGTGTTTGTCATCGTCTGTGCTCTGCCCGCCACTGTGTCCATGGTGGCTCTGAAGTTCATGCCAGAAAGCCCCAGGTTCCTGCTGGAGATGGGCAAACATGATGAAGCCTGGATGATTCTCAAACAAGTCCATGATACAAACATGAGAGCTAAGGGGACCCCGGAAAAGGTGTTCACGGTTTCCCACATCAAAACTCCCAAGCAAATGGATGAATTCATTGAGATACAGAGCTCAACCGGAACTTGGTACCAGCGCTGGCTGGTCAGGTTCATGACCATTTTCAAACAGGTCTGGGATAACGCCTTGTACTGTGTGATGGGGCCCTACAGAATGAACACCCTGATTCTGGCTGTGGTCTGGTTCACCATGGCCTTAAGTTACTACGGCCTGACGGTGTGGTTCCCCGACATGATCCGCTATTTCCAGGATGAAGAATATAAGTCTAAAATGAAGGTGTTTTTTGGTGAGCACGTGCATGGCGCCACGATCAACTTTACCATGGAAAACCAGATCCACCAACATGGGAAGCTTGTGAACGATAA 25921068 Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed. Rybak-Wolf A, Stottmeister C, Glažar P, Jens M, Pino N, Giusti S, Hanan M, Behm M, Bartok O, Ashwal-Fluss R, Herzog M, Schreyer L, Papavasileiou P, Ivanov A, Ohman M, Refojo D, Kadener S, Rajewsky N. Mol Cell. 2015 By northern blots, using probes detecting both linear and circular isoforms, we validated this circRNA to be specifically enriched in the brain, although its linear isoform mostly show much broader expression patterns across tissues. qRT-PCR, northern blots P19 and SH-SY5Y cells, primary forebrain neurons from CD1 mouse embryos (E17.5¨CE18.5) circAmotl1 circRNA mus musculus Amotl1 mmu_circ_0001745 mm9_circ_000340 CCGGCCCTGCCAGCTGCCTTTTCCATCTACGGTGCAGCAGCATAGCCCCATGTCCTCTCAGACCTCCTCCATCGGTGGTACTCTGCACTCCGTCTCCCTGCCTCTTCCACTTCCCATAAGCCTGGCGGCTTCACAGCCCCTACCAGCCTCCCCCAACCAGCAGCTTGGACCGGATGCCTTTGCGATTGTGGAGCGAGCCCAGCAAATGGTAGAGATCCTGACAGAGGAGAACCGTGTGCTTCACCAGGAGCTTCAGGGCTGCTATGACAACGCTGACAAGCTCCACAAGTTTGAAAAAGAGCTGCAGAGTATTTCGGAGGCCTACGAGAGCCTGGTCAAGTCCACCACCAAGCGTGAGTCTCTGGACAAGGCAATGAGAACCAAGCTCGAAGGCGAGATAAGGAGACTTCATGACTTCAACAGAGATCTCCGAGATCGACTGGAGACAGCCAACAGGCAGCTGTCCAGCAGGGAATACGATGGGCATGAAGACAAAGCTGCAGAGAGCCATTACGTGTCCCAGA wound healing 28676341 The Circular RNA Interacts with STAT3, Increasing Its Nuclear Translocation and Wound Repair by Modulating Dnmt3a and miR-17 Function. Yang ZG, Awan FM, Du WW, Zeng Y, Lyu J, Wu, Gupta S, Yang W, Yang BB. Mol Ther. 2017 Expression of the circular RNA circ-Amotl1 accelerated healing process in a mouse excisional wound model. Further studies showed that ectopic circ-Amotl1 increased protein levels of Stat3 and Dnmt3a. circ-Amotl1 not only increased Stat3 expression but also facilitated Stat3 nuclear translocation. the ectopic expressed circ-Amotl1 and Stat3 were mainly translocated to nucleus. In the presence of circ-Amotl1, Stat3 interacted with Dnmt3a promoter with increased affinity, facilitating Dnmt3a transcription. Ectopic application of circ-Amotl1 accelerating wound repair may shed light on skin wound healing clinically. loss of function, gain of function NIH 3T3, HGF mouse model Stat3 circRNA-protein predicted The molecular simulation result supports that circ-Amotl1 could perfectly dock Stat3 and predicts a minimal binding region of circ-Amotl1 for Stat3: ¡®AACCTTCAC¡¯¡®AAC¡¯¡®AGGAAGAA¡¯. The contact map, the residue-level resolution contact maps (Figure S6C), the MC score, the contact distance, the accessible surface area, and the interaction overview all supported the conclusion that circ-Amotl1 sufficiently docked Stat3. mmu_circ_0001796 circRNA mus musculus Zfp609 mmu_circ_0001796 mm9_circ_017858 CAATGATGTTGTCCACTGGACATGTTCTGACCAAGGAGGCAGGTCTGAGAACGTAGCTGAAGCTGAAAATAGGAAAGCTGGGGGCAAGGAAGAGCCTTGAACCTTGAGGTGGGACGTTGACTCTAAGATGTCCTTGAGCAGTGGAGCCTGCGGAGGGAAAGGAGTGGATGCAAACCCGGTTGAGACATACGACAGTGGGGATGAATGGGACATTGGAGTAGGGAACCTCATCATCGACCTGGACGCCGATCTGGAAAAGGACCAGCAGAAACTGGAAATGTCAGGCTCCAAGGAGGTGGGGATACCAGCCCCCAATGCTGTGGCCACACTACCAGACAACATCAAGTTTGTCACCCCAGTGCCAGGTCCTCAAGGGAAGGAAGGCAAATCAAAATCCAAAAGGAGTAAGAGTGGCAAAGACGCTAGCAAGCCCACTCCAGGGACTTCCTTGTTCTCTCCAAGTGAGGGAGCAGCCAGCAAGAAAGAGGTGCAGGGTCGCGCAGGAGATGGTGCCAGTGCGGGAGGCCTGGTTGCTGCTGTTGCTCCCAAGGGCTCAGAGAAGGCTGCTAAGGCGTCACGCAGTGTAGCTGGCTCCAAAAAGGAAAAGGAGAACAGCTCATCTAAGGGCAAGAAGGAGAGAAGTGAAGGCGTGGGGACTTGTTCGGAAAAGGATCCTGGGGTCCTCCAGCCAGTTCCCTTGGGAGGACGGGGTAGTCAGTATGATGGAAGTGCAGGGATGGACACAGGAACCGTGGAGCCGCTTGGGAGTATAGCTATTGAACCTGGGGCAGCGCTCAATCCTTTGGGAACTAAGCCGGAGCCAGAGGAAGGGGAGAATGAGTGCCGGCCACTAAAGAAAGTCAAGTCTGAAAAGATGGAGTCCCCAGTCTCCACCCCAGCGGTGCTGCCACTGCACCTGTTAGTGCCAGTGGTCAATAATGACATCTCATCTCCCTGTGAGCAGATCATGGTCCGTACCCGATCAGTTGGTGTCAACACATGCGACGTGGCTCTAGCCACAGAGCCTGAGTGCTTAGGCCCCTGTGAGCCTGGAACCAGCGTCAACCTTGAAGGCATCGTGTGGCAGGAAACAGAAGATG pulmonary toxicity induced by radon 29165116 Circular RNA profiles in mouse lung tissue induced by radon. Pei W, Tao L, Zhang LW, Zhang S, Cao J, Jiao Y, Tong J, Nie J. Environ Health Prev Med. 2017 The expressions of the circRNA was examined in mice of 60 WLM group. microarray, qRT-PCR BALB/c mice lung tissue circZfp609 circRNA mus musculus Zfp609 mmu_circ_0001797 mm9_circ_004501 CAATGATGTTGTCCACTGGACATGTTCTGACCAAGGAGGCAGGTCTGAGAACGTAGCTGAAGCTGAAAATAGGAAAGCTGGGGGCAAGGAAGAGCCTTGAACCTTGAGGTGGGACGTTGACTCTAAGATGTCCTTGAGCAGTGGAGCCTGCGGAGGGAAAGGAGTGGATGCAAACCCGGTTGAGACATACGACAGTGGGGATGAATGGGACATTGGAGTAGGGAACCTCATCATCGACCTGGACGCCGATCTGGAAAAGGACCAGCAGAAACTGGAAATGTCAGGCTCCAAGGAGGTGGGGATACCAGCCCCCAATGCTGTGGCCACACTACCAGACAACATCAAGTTTGTCACCCCAGTGCCAGGTCCTCAAGGGAAGGAAGGCAAATCAAAATCCAAAAGGAGTAAGAGTGGCAAAGACGCTAGCAAGCCCACTCCAGGGACTTCCTTGTTCTCTCCAAGTGAGGGAGCAGCCAGCAAGAAAGAGGTGCAGGGTCGCGCAGGAGATGGTGCCAGTGCGGGAGGCCTGGTTGCTGCTGTTGCTCCCAAGGGCTCAGAGAAGGCTGCTAAGGCGTCACGCAGTGTAGCTGGCTCCAAAAAGGAAAAGGAGAACAGCTCATCTAAGGGCAAGAAGGAGAGAAGTGAAGGCGTGGGGACTTGTTCGGAAAAGGATCCTGGGGTCCTCCAGCCAGTTCCCTTGGGAGGACGGGGTAGTCAGTATGATGGAAGTGCAGGGATGGACACAGGAACCGTGGAGCCGCTTGGGAGTATAGCTATTGAACCTGGGGCAGCGCTCAATCCTTTGGGAACTAAGCCGGAGCCAGAGGAAGGGGAGAATGAGTGCCGGCCACTAAAGAAAGTCAAGTCTGAAAAG 25921068 Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed. Rybak-Wolf A, Stottmeister C, Glažar P, Jens M, Pino N, Giusti S, Hanan M, Behm M, Bartok O, Ashwal-Fluss R, Herzog M, Schreyer L, Papavasileiou P, Ivanov A, Ohman M, Refojo D, Kadener S, Rajewsky N. Mol Cell. 2015 Some circRNAs showed even a reciprocal expression pattern during differentiation (such as circZfp609), which supports the previous finding that circularization can compete with linear splicing. Another example is circZfp609. Its mRNA is expressed on a constant level during neuronal differentiation, while the circRNA is highly upregulated in neurons. qRT-PCR, northern blots P19 and SH-SY5Y cells, primary forebrain neurons from CD1 mouse embryos (E17.5¨CE18.5) Cdr1as circRNA mus musculus Cdr1 mmu_circ_0001878 CDR1as GGTTTCCAGTGGTGCCAGTACCAAGGTCTTCCAACATCTCCAGGTCTTCCAGCAACTGCAAGTCTTCCAACACTGTCAAGGTCTTCCAGACAATCGTGATCTTCCAGAAAATATGTCTTCCAGATGATATATGTCTTCCAACAACCTCAGAGTCTTCCAGTAAATTCAGTCTTCCATGGTATCTAGATCTTCCGTGATATCTAGATCTTCTAGGAAAATCTGTGTCTTCCAGGAAAATCTTTGTCTTCCAAGGGATCCATGTCTTCCAGAAAAAAATCCACGTCTTCCAGAAAAATTCATGTCTTCCAGGAAAATCCATGTCTTCCAGAAAAATCCAAGTCTTCCAGAAGAATCTAAGTCTTCCTGAAAAATCCATGTCTTCCATAACAATCTACATCTTCCAGAATAATCAACGTCTTCCACAAAATTCAGGTCTTCCAGAAAAATATCCAGGTCTTCCAACCAGTCTATGTCTTCCAGAAAAATCCAGGTCTTCCAGCTCATCTATGTCTTCCATCAGTTCAAGTCTTCCAGATACCCATGTCTTCCATTAAATCTAGGTCTTCCAATAGATCTATGTCTTCCTGAAAATTAACGTCTTCCAATAATGTCCAAGTCTTCCAGCCAAGATATGTCTTCCTGAAGATTAATGTCTTCCTGAAGATTGACATCTTCCAGCAGAAAATCTTTGTCTTCCATTAAATCCACATCTTCCAGAAAATCCATGTCTTCCCAAAAATCCACATCTTCCAGGAAATCAACGTCTTCCCCAAAATCCATGTCTTCCTGAAAATCCACCGTCTTCCAAATAATCCAAGTCTTCCCAGAAATCGAAGTCTTCCCGAAAATCCATGTCTTCCCAAAAATCTACGTCTTCATGAAAATCTATGTCTTCCCAAAAATCCAAGTCTTCCCAGAAATCTAAGTCTTCCTGAAAATCCAAGTCTTCCCAAAAGTCCATGTCTTCCCAAAGATCCATGTCTTCCCGAAAATCCACGTCTTCTGGAAAATCGAAGTCTTCCCAGAAATCCAAGTCTTCTGGAAAATCGAAGTCTTCCCAGAAATCCAAGTCTTCCGGAAAATCGAAGTCTTCCCAGAAATCGAAGTCTTCCCGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCTGAAAATCCAAGTCTTCCTGAAAATCTAAGTCTTCCGGAAAATCTAAGTCTTCCAGAAAATCTACGTTTTCCCAGAAATCCAAGTCTTCCCAGAAATCCAAGTCTTCCCAGAAGTCCAAGTCTTCCTGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCAGAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCAGAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCAGAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCAGAAGTCCAAGTCTTCCCAGAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCAGAAGTCCAAGTCTTCCCAGAAGTCCAAGTCTTCCCGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCAGAAGTCCAAGTCTTCCCAGAAATCCGAGTCTTCCCAGAAGTCCAAGTCTTCCCAGAAATCCGAGTCTTCCCAGAAATCCAAGTCTTCCCAGAAGTCCAAGTCTTCCCGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCAGAAATCCGAGTCTTCCCAGAAATCCGAGTCTTCCCAGAAATCGAAGTCTTCCCAGAAATCCGAGTCTTCCCAGAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCAAAAATCCAAGTCTTCCCAGAAATCCGAGTCTTCCCAGAAATCCAAGTCTTCCCAGAAGTCCAAGTCTTCCCGAAAATCCAAGTCTTCCCGAAAATCCAAGTCTTCCCAGAAATCCAAGTCTTCCCAGAAGTCCGAGTCTTCCCAGAAATCCGAGTCTTCCCAGAAATCCGAGTCTTCCCAGAAATCCGAGTCTTCCCAGAAATCCAAGTCTTCCCAGAAATCCGAGTCTTCCCAGAAGTCCAAGTCTTCCCAGAAGTCCAAGTCTTCCCAGAAATCCGAGTCTTCCCAAAGATCCACTTCTTCCCAGTAATCTGTGTCTTTCCAGAAATCCGTGTTTTCCCGAAAATCCAAGTCTTCCCGAAAATCAATGTCTTCCTGAAAATCCAAGTCTTCCCAGAAACCCATGTCTTCCTGAAAATCCATGACTTCCCAAAAATCCAAATCTTCCTGAAAAATCCATATCTTCCCAAAAATCCACGACTTCCCAAAAATCCATGTCTTCGTGAATATCCACGTCTTCCTGAAAATCCAAGTCTTCCCAGAAATCCATGTCCTTCCAAAAATCCATGTCTTCCTGAAAATCTATGCCTTCCATAAATCTACATCTTCCTGAAAATCCACATCTTCCTGAAAATCTACATCTTCCTGAAAATCCACATCTTCCATAAATCCCAGTCTTCCCAGAAATCCAAGTCTTCTGGAAAATCCATGTCTTCCTGAAAATCTATGCCTTCCACAAATCCATGTCCTCCTAACAATCCAAGTCTTCCTAAAAATCTACGCCTTCCACAAATCTACATCTTCCTGAAAATCCACATCTTCCCAAAATCCATGTCTTCGGAAAAAATCCATGTCTTCCAAGGAGTACATGTGTCTTCCTTCACCTCCAAGTCTTCCAGCATCTCCAGGGCTTCCAGCATCTGCCTGTCTTCCAACATCTCCACATCTTCCAGCATCTTTATGTCTTCCAACAACTGCGCAGTGTCTCCAGTGTATCGGCGTTTTGACATTCAGGTTTTCTGGTGTCTGCCGTATCCAG 25921068 Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed. Rybak-Wolf A, Stottmeister C, Glažar P, Jens M, Pino N, Giusti S, Hanan M, Behm M, Bartok O, Ashwal-Fluss R, Herzog M, Schreyer L, Papavasileiou P, Ivanov A, Ohman M, Refojo D, Kadener S, Rajewsky N. Mol Cell. 2015 By northern blots, using probes detecting both linear and circular isoforms, we validated this circRNA to be specifically enriched in the brain, although its linear isoform mostly show much broader expression patterns across tissues. qRT-PCR, northern blots P19 and SH-SY5Y cells, primary forebrain neurons from CD1 mouse embryos (E17.5¨CE18.5) circ-Zfp62 circRNA mus musculus Zfp62 mmu_circ_0003067 GAAGTTGAAATGGAAGGTCTAAAATTGAAAAGTAAATGGATGGAAAATCTGATATATGTGGACATGGCAGAGTATAGATAAGGTGAAGAAACTGCTGTACAAAGAAGTTAAATAGCTATCCCAAAGGTCATATAAGTAGGTATTTGAACCTAGTTGGTATTCTAGTCATTTTCTGGTCTGTGTGAGAGATTGGGTTTAATATTTCACAGATAGCAGAGTCCACTACAGAGGTTGGAGTTCCTTATTTAAAACAACAGTATTTACATATGACCTTTACACATCATCCTGTGTACTTGAAATTATTTTCAAATTACTTGCAGTGCCTAAAAGCAGTGTGAATCTTTATTTCGTTGTATTATTTAGAGAATAATGATAAACATTAAAAGCTGTATATGTTCAGCACAAATGTAACTTTGTTTTTCTGGTATTTTGGGTCCATGGTTGGCTGAATCTGTAAATGCAGAACCTGCCGCTGTGAAGGGCCAACTACTCTCCTCAGTGGCTTGAGGTGTTGCTGTCTTGTTTTAGCATCCGTGAGACAAAGATCTTATGCCATAGTTCAGGCTGGCCTGGAACATGCAGTAACCTTCCTGCCTCAGCCTCCAAAGTGCAAGAATAATAAGATTGAGCCATTACACTTTGCTATTTGTAAGCTTTGACATTCTATATGACTAATTGATTCATAAATAGGAATGAAAACTTTATTCCTTGGCAGGCTGGAGCATGTTTCTACCATGTAAGTTCTTCCATGATTAGCCACTTTCCAAAGAGTGTTTTCCTTACACAGAAAAGTCAAGAAGGCCAAATTACGGTATAGTAGCTTTAGGTTTCTTTGTTTCTCATTTCTTGGTCACTGTCCTCATCATCTTATAACTGCAACTCCCTGCCTGATTCCTCTTCTACGGTCCTGACTTATCTTCCTTTTCAGTTTTTCCTGCTCTCTCCTGATTATGTGTAACTTTTCAAAGAAAAAATTAACATCTTTGTTGTTCTAACTTTTTTCTGTCATGTTTTTCAGAGACTTCTTTTTTCTTGTTTTTCTATGAGGTGACATTGAAACTGATTGGTATTGGCTGTGGTTTTGTGCATCAGTTGAACCCATTTTTATGGTACCTTCTGGACTCTTGTTTTAACAGTAGTTCTAAAGGTATTGAAATCTTATTAATGTCCCCCATCATAATTCCAGTAATTAAAATGGTACTGGAAGGGCTGGAGAGATGACTTAGCAGTTAAGAGCATTTGATGCTCTTGCAGAGGACCTGGGTCCAGTTCCCAACACCCTATGATCACACCCAACCATCCATGCTAACTCCAGTTCCAGAGGGATCTGACTACCTCTTCTGAACTCAATGGGCACCAGACATGTGCATGGTGCACATTCCTCCAAGAAAGCAAAAACACTCAAAAAAATTTAAAGATTATTTTTTAAATGGTACCTGCCACATATTAAAAAGCAAATATCTGACAAATGGATAAGTTAATTTTGTTATTTGCTGTTGTTACTCATTCAGGGTTTTTTCCTAAATAAACATGTCATTTTCATTCTTTTGGTCTAGTGTCATATTTGAAGACAACCATGGAGGATGAGGAGTCGTCTAAAAAGAATGAAAATGATTCAAATGCAGACTCTCAGTGCCCAAGTGTGGGATTTTTTCATAAGGATCATATGCAGAAATCTAAGACCGGTGACACTTGTGACTTGTTTCCTAAATGGAAAATACTGAAGGAAGGCAAAAGTAGTATCAGAGAAATGATTGACACACATACAAACGCAGCAAATATAAAACTAGAGCAGGATGATGAGACATCTGAGAAAAGTTTCTACCCAAGTACAAATACAATGCACCAGACTATCCCCACAGAACCAAATTGTACTAAACAAGGTGAGCACACAGAGAACATTAATGGAAACGTACACCCTGCTCATATTGCTGATAAGAAATTACATAAGTGTGATGAGTGTGGAAAATCCTTCAAATACAATTCTCGTCTTGTTCAACATAAAATTATGCACACTGGAGAAAAGCGCTACGAGTGTGATGACTGTAGGGGGACTTTTCGGAGTAGCTCCAGTCTTCGAGTCCACAAGCGCATCCATACTGGGGAAAAGCCCTATAAGTGTGATGAGTGTGGCAAAGCCTACATGTCCTACTCTAGCCTTATAAACCACAAAAGCACTCATTCTGGGGAGAAGAACTGCAAATGTGACGAATGTGGAAAATCCTTCAATTATAGTTCTGTTCTGGACCAGCATAAAAGGATCCACACCGGAGAGAAGCCCTATGAATGTG aging 27958329 CircRNA accumulation in the aging mouse brain. Gruner H, Cortés-López M, Cooper DA, Bauer M, Miura P. Sci Rep. 2016 Significantly increased at 6 mo compared to 1 mo. RNA-seq, qRT-PCR 22 mo cortex, 6 mo cortex, 1 mo cortex circ-Onecut2 circRNA mus musculus Onecut2 mmu_circ_0007448 CATGCAAACGCAAAGAGCAAGAACCAAACAAAGACAGGAACAACTCGCAGAAGAAATCCCGCCTGGTGTTCACGGACCTCCAACGCCGAACACTCTTCGCCATCTTCAAGGAAAATAAGCGCCCTTCGAAGGAGATGCAGATCACCATTTCCCAGCAACTTGGGCTGGAGCTGACCACTGTCAGTAACTTCTTCATGAATGCCCGGCGTCGCAGCCTGGAGAAATGGCAAGATGACCTAGGCACAGGGGGTTCTTCATCCACCTCCAGCACTTGTACCAAAGCATGATGCAAGGACTCTCCACCTGGGCACAAGTCATCTCCAAATGAGGACAACACATACCAAAAACCAAAACCAAAAACCAAAACCAAAACCAAAACCAAAACCAAAACCAAAAAAAAAAAAAAAAAAAAATCACAAAGACATCAGATTCTTAGCTGGGGCCCTTCACTGGTGACTTGAAAGCACAATTCTCTTGAAACTTCTAATCTAGCTGTAATCATAGGCCAGGTGTCCATTTTCTTTTGTTTCATTTTAAATGGCTACAGAGTCCAAGTACACGCTGAAAGTTAATCTCTTTGAACCAGACACTATCCTCTGAGTATGCTAAGCATCCCAGAGACCCAAATGGGGCCTTCTTGGAGTGAGTTAATCACAGCACAATGTCAACCAAGTTCAGTGCAGCTGTAAGCATCAATAGCCCTATTCAGGCCCTGTCAACCTCTTGCTAACACTAGTTTCCTGCAAGTCATAGTGGATATTTGGCCTGAGTATAGACACAGGATTCCAAAACACTACAGAAGAATTTAACAAGAAAGGCCTCATTTGCTCCCCAAGTGCTTAGCCTCTTTATATCACAGTACATTAAAAATTCTCAGCCATAACATTACAAAAAAAAATCAGAATGGTAATTACTGAGCACAAGTTTTAAATATGGAAATCAATAAAAAAAATCCAAGGACATGTTTTTCCAACTCAGGCATCTTTTCATTGGATAGTTTAGAAAACTTTGATTTCAGTTTACGATTTTTCTTTTCTTTACCTCCTGGAAATCTCATGTGGTCTTCTGGATCCGTCAAAAAAAAGTCAATTCACTTGAGCTCAAAGTATCAAGCACAACGAAGATATACAGAAATAAGGAAGGCTCTGGTTTCAACGCATCCAGTTTGACAAGGCCGTTTACATCAGTCTTTACTGTTGTGAAGTCATTAGGGAATTATTGGGAATATGGCTTCAAGCACATTTTGCAGGTTGTTACAAACTCTGTTTGTACATTGCGCAGATGCACACTCAGGAGGCCAATTTAACTGCTACAGTACAGGAGCAAATGCATCATTTAAGAAGATCTAGATTTTTTTAGATCATTACTGTGCCCTTGATTTACAAGTCACCCAGGTCCTCCTATGTGCATTACAAGTGTGGTTTGTTCTTGTTCTTGCTGATCCGTGTTGTTCCCTATCGCATCCCATTAGTTGGGATGTCTCTATTGTTTTCTACAAAGAAACAGTTTAATAAGCCACTTCCTGTCGTCTCTTCCTAACTCTCTTCCATTGCTGATTCATCCTTATAATACAGCTGACAGAACCTGGAGAGAACACAGCACACCAAAGAAGCAGAATACTGCAAACCAAAGACATTTGTTACCTGCCATTTTCTAGCCTACAAATACTGTGATTACTTTTAGAGATCAGAGCACCTCTGTAACTCCGAGTGGCATTCGGCTCTTGTCTTGGGCTCACCACCTGGCTGAGCAGACCAGCTACATCAATGACATTAGCCAAATATCCGGGCAGTGACTTCGCCACGCCAGCCCTGGTTGGTCACCTTCCCATAGCAAGTGAAAGAGGGCCCACAGAACTCTGGGAGATTACAAAGGTCACTATGTGCATATTTACCAGTGAATGGCCCCAGGTGGGCACCAAGGGGTGTTCGGAGCAAGCCAAAAGCTTCGATGACTCTTTACAGACACTTGAGACTGACTTTTGTATGAATTGCTTAATTGAAACCAAAGAAACTTTTTTTCTGCACCTACTTCTGCAACAAACAGAACTGTCCCATTGAATGAGTAAATGGTTCCACCAATCACTGGAAATCACCATCAACAGAAAAAGCACGCTAGAATGAAAGAAACAACAAAACCACCGAAGACACACTGTGTTCAAACAGACCTTTTGGGACGCTCTTATTTTTTATTTTTTTATTTTTTGGAAGCAGATTTGAAAGAAAGGGTTGAGACACAAATCAACAGACGAGCCTCAATGGCTGCTGCTTCATATGACAACTCACTCGGTAATCTTAACGTTGAAGATTGTCTTTAATTTGTGCCTATGCAGTTTTTCAAAAGAACATGGAAACAGAGCAACAGAAACCTCAACAGCTACAATACCAAAGATGAGGATTCTCACACCTTTTTGTCTCAGTTCATTACCTTCTTTTGCCTGGCTAAAATACTTATAGCGTCATTGATCTGTACAAAG aging 27958329 CircRNA accumulation in the aging mouse brain. Gruner H, Cortés-López M, Cooper DA, Bauer M, Miura P. Sci Rep. 2016 Significantly increased at 6 mo compared to 1 mo. RNA-seq, qRT-PCR 22 mo cortex, 6 mo cortex, 1 mo cortex circ-Fmn2 circRNA mus musculus Fmn2 mmu_circ_0008444 CAAGATCAGCTTTACACCTGGGCTGCGGTTAGTCAACCCACACATTCGATGGATTACAGCGAAGGGCAGTTTCCCAGGAGAGAACCATCTATGTGGCCATCATCCAAGCTTCCTGAGGAAGAGCCCAGTCCCAAGGACGTTGATACAGAACCTAAATCCTCTATTTTGGAAAGCCCGAAAAAATGCTCAAATGGTGTCCAGCAGGAAGTTTTCGATGTGAAGTCTGAAGGACAGGCAACTGTAATTCAGCAACTGGAACAGACCATCGAGGATCTACGCACAAAAATAGCTGAGCTAGAGAAGCAATATCCAGCCCTGGACTTGGAGGGACCCAGAGGCCTCTCAGGACTTGAGAATGGATTGACAGCCTCTGCAGACGTCAGTCTAGATGCTCTTGTATTGCATGGGAAGGTTGCACAGCCTCCAAGGACTCTTGAGGCAAAATCAATACAGACTTCCCCAACAGAAGAAGGTAGAATCCTGACATTGCCACCTCCAAAGGCACCACCAGAGGGTCTTCTGGGGTCCCCTGCAGCTGCAAGTGGAGAGTCAGCCCTTCTAACCTCACCCTCTGGACCTCAGACAAAATTCTGTTCAGAGATTTCTCTGATTGTGTCTCCAAGGAGAATATCAGTACAGCTGGATGCCCAACAGATACAGAGTGCATCACAACTACCACCACCTCCTCCTCTCCTTGGGTCTGATAGTCAGGGACAGCCCTCCCAACCTTCTCTGCATACTGAGTCAGAAACCAGCCATGAACATTCTGTTTCCTCCTCCTTTGGAAACAACTGTAATGTCCCACCCGCACCACCTCTGCCTTGTACAGAGTCCTCCAGTTTCATGCCTGGCCTGGGCATGGCAATTCCCCCACCTCCCTGTCTCTCTGACATAACAGTGCCTGCTCTGCCCAGTCCTACAGCCCCAGCCCTACAATTTAGCAATCTACAGGGACCAGAAATGCTGCCAGCCCCTCCCCAACCTCCTCCTCTTCCTGGGCTAGGAGTACCCCCTCCTCCCCCTGCCCCTCCTCTCCCTGGAATGGGAATACCTCCCCCACCTCCTCTCCCTGGAATGGGAATACCTCCCCCACCTCCTCTCCCTGGAATGGGAATATCTCCCCTACCTCCTCTCCCTGGAATGGGAATACCTCCTCCCCCTCCTCTACCTGGAGTGGGCATACCCCCTCCTCCTCCTCTTCCTGGAGTGGGCATACCCCCTCCTCCTCCTCTTCCTGGAGTGGGAATACCCCCTCCTCCTCCTCTTCCTGGAGTGGGAATACCTCCTCCCCCTCCTTTACCTGGAGTGGGAATACCCCCTCCTCCTCCTCTTCCTGGAGTGGGCATACCCCCTCCTCCTCCTCTTCCTGGAGTGGGAATACCCCCACCCCCTCCACTTCCAGGAGTGGGAATACCCCCTCCCCCTCCTTTACCTGGATCAGGCATACCCCCTCCTCCTGCTCTACCTGGAGTTGCTATTCCTCCACCACCTCCTCTACCAGGTATGGGGGTTCCACCTCCCGCCCCACCTCCCCCTGGGGCAGGCATCCCCCCACCCCCACTGTTGCCTGGCTCAGGTCCTCCACACTCCTCACAAGTTGGGAGTAGCACTTTACCAGCAGCACCTCAAGGGTGTGGATTTCTTTTTCCTCCATTGCCCACTGGCTTGTTTGGATTAGGGATGAATCAGGACAGAGTGGCTAGGAAGCAGCTGATCGAGCCTTGCCGGCCAATGAAGCCTCTCTATTGGACAAGAATTCAACTCCATAGTAAAAGAGACTCCAGCCCTTCGCTTATTTGGGAAAAGATTGAAGAGCCATCCATAGACTGTCATGAATTTGAAGAATTATTTTCTAAAACTGCAGTAAAGGAGAGAAAGAAACCTATTTCTGACACAATTTCAAAGACAAAGGCCAAACAA aging 27958329 CircRNA accumulation in the aging mouse brain. Gruner H, Cortés-López M, Cooper DA, Bauer M, Miura P. Sci Rep. 2016 Significantly increased at 6 mo compared to 1 mo. RNA-seq, qRT-PCR 22 mo cortex, 6 mo cortex, 1 mo cortex circ-Pclo circRNA mus musculus Pclo mmu_circ_0012310 ATCAAAGAGTGGCTCTGTTTAAACTGTCAGATGCAAAGAGCTCTGGGAGGTGAACTGGCAGCAATCCCATCCTCACCGCAGCCAACCCCAAAGGCTGCCTCAGTACAGCCAGCAACAGCCAGCAAATCACCTGTACCGTCACAGCAGGCTTCCCCAAAGAAGGAACTTCCATCCAAACAGGACAGCCCCAAAGCACCGGAGTCCAAAAAGCCACCGCCACTGGTGAAACAGCCAACCCTTCATGGACCTACCCCGGCTACAGCCCCACAGCCTCCAGTGGCAGAGGCCTTACCTAAGCCAGCCCCTCCCAAGAAGCCTTCTGCAGCCCTACCTGAACAAGCAAAGGCCCCTGTTGCAGATGTTGAACCAAAGCAACCGAAGACGACAGAGACACTCACAGATAGCCCATCTTCAGCAGCAGCAACCTCAAAGCCTGCTATTCTGAGCTCTCAAGTGCAGGCACAGGCTCAAGTGACAACGGCCCCTCCTTTGAAAACAGACTCTGCCAAAACTTCACAGAGTTTCCCACCAACAGGAGATACAATTACCCCACTTGATTCTAAAGCCATGCCCAGGCCTGCATCAGACTCAAAAATTGTTTCACATCCTGGGCCCACTTCTGAGAGCAAGGATCCAGTTCAGAAGAAGGAGGAGCCTAAGAAAGCACAAACCAAGGTGACCCCTAAACCAGATACAAAGCCAGTACCAAAAGGATCCCCAACACCGTCTGGCACACGACCTACGACTGGCCAAGCCACACCCCAGTCTCAGCAGCCCCCGAAGCCTCCGGAGCAGTCAAGACGGTTCAGTTTGAATCTGGGGGGTATCGCTGATGCCCCCAAATCACAGCCCACAACTCCTCAAGAAACTGTGACAGGGAAGCTATTCGGGTTCGGAGCATCCATCTTTAGCCAAGCATCAAACTTAATTTCCACAGCAGGTCAGCAAGCACCTCATCCACAGACTGGGCCAGCTGCCCCATCAAAGCAAGCCCCTCCCCCATCCCAGACTCTGGCTGCTCAGGGACCACCCAAGTCCACAGGTCCGCACCCATCAGCACCTGCCAAGACGACTGCTGTGAAGAAGGAAACAAAAGGCCCGGCAGCTGAAAACTTAGAGGCCAAACCTGTGCAAGCTCCAACAGTGAAGAAGGCAGAGAAAGACAAGAAGCCCCCACCTGGGAAGGTCAGCAAACCTCCACCTACAGAGCCCGAGAAGGCCGTCCTCGCCCAGAAGCCAGACAAGACCACCAAACCCAAACCGGCCTGTCCTCTCTGCAGAACGGAACTCAACGTAGGGTCTCAGGATCCTCCCAACTTCAACACCTGCACAGAATGCAAGAATCAAGTTTGCAATCTCTGTGGATTTAACCCAACGCCCCACCTGACTGAG aging 27958329 CircRNA accumulation in the aging mouse brain. Gruner H, Cortés-López M, Cooper DA, Bauer M, Miura P. Sci Rep. 2016 Significantly increased at 6 mo compared to 1 mo. RNA-seq, qRT-PCR 22 mo cortex, 6 mo cortex, 1 mo cortex circ-Kdm3a circRNA mus musculus Kdm3a mmu_circ_0013507 CCCCAGCCCGGAAGTCAGTTTTGACAGACCCAGATAAAGTCAGGAAGCTGCAGCAGAGCGGAGAGGCCTTTGTTCAGGATGACTCCTGTGTTAACATCGTGGCACAGCTGCCCAAGTGTCGGGAGTGTCGACTAGACAGCCTGCGCAAGGATAAGGACCAGCAGAAGGACTCTCCTGTGTTTTGTCGCTTTTTCCACTTCAGGAGATTACAATTCAACAAGCATGGTGTGTTGCGGGTAGAAGGCTTCTTAACACCAAACAAGTATGACAGTGAAGCGATTGGCTTGTGGCTGCCTTTGACCAAAAATGTTGTGGGGACTGATTTGGACACAGCAAAATATATCCTGGCCAATATTGGAGACCACTTCTGTCAAATGGTGATTTCTGAGAAGGAAGCTATGTCGACTATTGAGCCACACAGACAGGTTGCTTGGAAACGAGCTGTCAAAGGAGTTAGAGAAATGTGTGATGTGTGTGACACAACCATTTTCAACCTGCACTGGGTGTGCCCTCGGTGTGGGTTTGGAGTATGTGTAGATTGCTACCGGATGAAGAGGAAGAACTGCCAACAGGGTGCTGCCTACAAGACTTTCTCTTGGATAAGGTGTGTGAAGAGTCAGATACATGAGCCTGAGAACCTGATGCCCACACAGATTATTCCTGGCAAAGCCCTCTACGATGTTGGAGACATTGTGCATTCTGTCAGAGCAAAATGGGGCATAAAGGCCAATTGTCCCTGCTCCAACAGGCAGTTCAAGCTCTTCTCAAAGCCAGCCTTAAAGGAAGACCTGAAACAGACATCCTTGTCTGGAGAAAAACCAACTCTTGGGACCATGGTCCAGCAAAGTTCCCCTGTTTTGGAGCCAGTGGCTGTGTGCGGGGAAGCAGCCTCCAAGCCAGCCAGCAGCGTGAAGCCCACCTGTCCCACCAGCACTTCACCTTTAAACTGGCTAGCTGACCTTACCAGTGGGAATGTCAACAAGGAGAATAAGG aging 27958329 CircRNA accumulation in the aging mouse brain. Gruner H, Cortés-López M, Cooper DA, Bauer M, Miura P. Sci Rep. 2016 Significantly increased at 6 mo compared to 1 mo. RNA-seq, qRT-PCR 22 mo cortex, 6 mo cortex, 1 mo cortex circ-Cwf19l2 circRNA mus musculus Cwf19l2 mmu_circ_0015534 TCCAGAGGCAGAGTCCACCTATATCTTAAATGTTGATGAAAAGAACAAGTTGGGGGCCAAGATTATCAAGGCAGAAATGATGGGGAATATGGAATTAGCTGAACAACTTAAAGCCCAACTTAAAGAGGCAAATAAATTTAAAGAAACACAGATGCCGGCAAAAAGATTGGGCGTAGAGCATGAAGATGAACAAGAAGTAATCCTTATTCAAACAGATAAGTCTGGAAGAATGTGGCCTGTGAGCAGCCCTAGAGAAACCCTGGATATGAAAGCAGAACGAAGGAAGAGAAAGAGAGTTTCAACCCATGAGGATAAAGAAAGGGTCCGATACTTTCCTGATGATGATCATTTGAGCCTCAAAGATTTAGTCAAGAATGAGAAAATAGGAACAGATATCAACCAAAACAGACTTTTCATGAAAATGGCATCTAAGTTTATGGGAAAATCAGATGAAGACAATTATACTCTGGATGACATGTTTGTCTCCAAAGCAGCTGAGAAAGAGCATCTTGGTAAGAAGGAAGAGAGCCAGAGGAGAAGAGCGATTGCTGAGCACCAGAGTCTTGCTGCAAAAATGGCAAAGTGCCTTTACTGTTTTGACAGCTCTCAGTTCCCCAAGCACCTTATTGTTGCAATCGGTGTGAAGGTTTATTTATGTTTACCCAGTTTCCAGTCTCTTACTGAAGGACACTGCTTCATAGTCCCTCTGCAACATCATCAAGCAGCCACTGTATTAGATGAAGATGTCTGGGAGGAGATCCAGATGTTTCGAAAATCATTGGTAAAAATGTTTGAAGATAAAGAATTGGATTGTATCTTTTTGGAGACTAATATGGGTTTGAAGAAACACTATCATATGGTTTATGAGTGTATCCCTCTCCCAAAGGAAGTGGGTGATATGGCTCCCATCTATTTTAAGAAAGCCATAATGGAATCTGATGAAGAATGGTCCATGAATAAGAAGTTGATTGATTTGTCTTCAAAAGATATTAGAAAGTCT aging 27958329 CircRNA accumulation in the aging mouse brain. Gruner H, Cortés-López M, Cooper DA, Bauer M, Miura P. Sci Rep. 2016 significantly increased between 6 mo and 22 mo hippocampus. RNA-seq, qRT-PCR 22 mo hippocampus, 6 mo hippocampus, 1 mo hippocampus. heart-related circRNA (HRCR) circRNA mus musculus cardiac hypertrophy and heart failure 26802132 A circular RNA protects the heart from pathological hypertrophy and heart failure by targeting miR-223. Wang K, Long B, Liu F, Wang JX, Liu CY, Zhao B, Zhou LY, Sun T, Wang M, Yu T, Gong Y, Liu J, Dong YH, Li N, Li PF. Eur Heart J. 2016 expressed in cardiomyocytes and mouse heart qRT-PCR, northern blots, FISH adult male C57BL/6 mice (8¨C10weeks old), cardiomyocytes acts as an endogenous miR-223 sponge to inhibit cardiac hypertrophy and heart failure gain of function cardiomyocytes adult male C57BL/6 mice (8¨C10weeks old) miR-223 circRNA-miRNA mouse heart AGO2 IP, RNA pull-down, FISH Fluorescence in situ hybridization (FISH) revealed that there is a co-localization between HRCR and miR-223 in cytoplasm. HRCR could pull down miR-223. HRCR pull down by AGO2 was specifically enriched in miR-223-transfected cells but not miR-223 mutant-transfected cells. ARC mmu_circRNA_007893 circRNA mus musculus 29039515 Calcitonin gene-related peptide induces IL-6 expression in RAW264.7 macrophages mediated by mmu_circRNA_007893. Deng T, Yang L, Zheng Z, Li Y, Ren W, Wu C, Guo L. Mol Med Rep. 2017 mmu_circRNA_007893 expression increased stably by ~2 fold relative to the control group. The data was in accordance with the results in the circRNAs microarray. mmu_circRNA_007893 were located mainly in the cytoplasm. microarray, qRT-PCR, FISH RAW264.7 macrophages Silencing of mmu_circRNA_007893, IL 6 mRNA expression was significantly decreased, whereas mmu miR 485 5p expression was markedly increased. Furthermore, when overexpression of mmu miR 485 5p, IL 6 mRNA was markedly decreased. The results demonstrated that CGRP induced IL 6 mRNA expression was mediated by mmu_circRNA_007893, and mmu_circRNA_007893 functioned as an endogenous mmu miR 485 5p sponge as part of induction of IL 6 mRNA expression. loss of function RAW264.7 macrophages mmu miR 485 5p circRNA-miRNA RAW264.7 macrophages expression, qRT-PCR mmu_circRNA_007893 regulates IL 6 mRNA expression by mediating the level of mmu miR 485 5p. IL-6 circRar1 circRNA mus musculus Rar1 lead induced neuronal cell apoptosis 27604105 A novel regulatory network among LncRpa, CircRar1, MiR-671 and apoptotic genes promotes lead-induced neuronal cell apoptosis. Nan A, Chen L, Zhang N, Liu Z, Yang T, Wang Z, Yang C, Jiang Y. Arch Toxicol. 2017 markedly upregulated in the hippocampus. upregulated in lead-treated N2a mouse nerve cells. qRT-PCR mouse cerebellum, pons, medulla oblongata, hippocampus and cerebral cortex. lead-treated N2a mouse nerve cells circRar1 promote apoptosis in lead induced neurotoxicity loss of function, gain of function lead-treated N2a mouse nerve cells miR 671 circRNA-miRNA lead-treated N2a mouse nerve cells FISH,luciferase reporter assay These results indicate that lncRpa and circRar1 interact directly and specifically with miR-671. Akt2, caspase8, and p38 circRNA_010567 circRNA mus musculus myocardial fibrosis 28412345 A novel identified circular RNA, circRNA_010567, promotes myocardial fibrosis via suppressing miR-141 by targeting TGF-β1. Zhou B, Yu JW. Biochem Biophys Res Commun. 2017 circRNA_010567 was markedly increased in diabetic mouse myocardium. CircRNA_010567 expression was confirmed in mouse myocardium using qRT-PCR, which showed circRNA_010567 was significantly up-regulated in myocardium. microarray, qRT-PCR diabetic mouse myocardium Functional experiments revealed circRNA_010567 silencing could up-regulate miR-141 and down-regulate TGF-b1 expression, and suppress fibrosis associated protein resection in CFs, including Col I, Col III and a-SMA. Results demonstrate the circRNA_010567/miR-141/TGF-b1 axis plays an important regulatory role in the diabetic mice myocardial fibrosis model. loss of function mouse cardiac fibroblasts miR-141 circRNA-miRNA db/db diabetic mice myocardium luciferase report assay circRNA_010567 directly targeted miR-141 and mediate it negatively. TGF-beta1 circRNA_Atp9b circRNA mus musculus Atp9b TTGGCAGTCTGCGAGTAAACTTGGATATGGGCAAAGCAGCATATGGATGGATGATTATGAAAGATGAGAATATTCCTGGTACAGTTGTTCGGACCAGCACAATACCAGAAGAACTTGGACGCCTGGTGTACTTACTGACAGACAAAACAG*GTAAAGTTCAAGTTAAGAGCTCAGACATACAAGTTGGAGACCTCATCATAGTGGAAAAGGTTGATACATTTTTTTAATATATTTTAAATCTGTATGTTCAACAGTCATTAACATTAGCTTAATTACAAGTAACGTTAACTTCAAATGAAC osteoarthritis 29305974 Circular RNA Atp9b, a competing endogenous RNA, regulates the progression of osteoarthritis by targeting miR-138-5p. Zhou ZB, Du D, Huang GX, Chen A, Zhu L. Gene. 2018 Compared with the normal control group, circRNA_Atp9b expression levels were significantly up-regulated in IL-1¦Â-induced chondrocytes in a time-dependent manner. qRT-PCR chondrocytes Knockdown of circRNA_Atp9b promoted the expression of type II collagen while inhibiting the generation of MMP13, COX-2 and IL-6. circRNA_Atp9b regulates OA progression by modulating ECM catabolism and inflammation in chondrocytes via sponging miR-138-5p. loss of function chondrocytes miR-138-5p circRNA-miRNA chondrocytes luciferase reporter assay these results illustrate that circRNA_Atp9b directly targets miR-138-5p by functioning as sponge. Cdr1as circRNA mus musculus Cdr1 neuropsychiatric disorders 28798046 Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function. Piwecka M, Glažar P, Hernandez-Miranda LR, Memczak S, Wolf SA, Rybak-Wolf A, Filipchyk A, Klironomos F, Cerda Jara CA, Fenske P, Trimbuch T, Zywitza V, Plass M, Schreyer L, Ayoub S, Kocks C, Kühn R, Rosenmund C, Birchmeier C, Rajewsky N. Science. 2017 Cdr1as was highly expressed in neurons but not expressed in glial cells such as oligodendrocytes and astrocytes. Cdr1as was predominantly expressed in excitatory neurons. In the cerebellum, Cdr1as expression was observed exclusively in the granular layer with a high content of excitatory neurons and did not overlap with GABAergic neurons present in the molecular layer and Purkinje cells. Single molecule RNA FISH in primary cortical neurons revealed Cdr1as expression in both soma and neurites. FISH neurons, glial cells such as oligodendrocytes and astrocytes, excitatory neurons, cerebellum, soma and neurites. When the Cdr1as locus was removed from the mouse genome, knockout animals displayed impaired sensorimotor gating¡ªa deficit in the ability to filter out unnecessary information¡ªwhich is associated with neuropsychiatric disorders. Electrophysiological recordings revealed dysfunctional synaptic transmission. Expression of miR-7 and miR-671 was specifically and posttranscriptionally misregulated in all brain regions analyzed. Expression of immediate early genes such as Fos, a direct miR-7 target, was enhanced in Cdr1as-deficient brains, providing a possible molecular link to the behavioral phenotype. loss of function Cdr1as loss-of-function mutant mice miR-7 and miR-671 circRNA-miRNA cerebellum, cortex, hippocampus, and olfactory bulb Northern blots, FISH, and chromogenic ISH there is a highly specific, posttranscriptional deregulation of miR-7 and miR-671 in the brains of Cdr1as KO animals. These are the two miRNAs that we identified by in vivo chimera analysis as directly interacting with Cdr1as. Fos circRNA.36866 circRNA mus musculus Osteoarthritis 29247798 Circular RNA expression profile of articular chondrocytes in an IL-1β-induced mouse model of osteoarthritis. Zhou Z, Du D, Chen A, Zhu L. Gene. 2018 Up-regulated in IL-1¦Â-induced mouse articular chondrocytes compared to controls. RNA-seq, qRT-PCR IL-1¦Â-induced mouse articular chondrocytes, controls mmu-miR-5124b, mmu-miR-6361, mmu-miR-3473b, mmu-miR-3473e, mmu-miR-6369 circRNA-miRNA predicted circRNA.30365 circRNA mus musculus Osteoarthritis 29247798 Circular RNA expression profile of articular chondrocytes in an IL-1β-induced mouse model of osteoarthritis. Zhou Z, Du D, Chen A, Zhu L. Gene. 2018 Down-regulated in IL-1¦Â-induced mouse articular chondrocytes compared to controls. RNA-seq, qRT-PCR IL-1¦Â-induced mouse articular chondrocytes, controls mmu-miR-7216-5p, mmu-miR-6238, mmu-miR-7094b-2-5p, mmu-miR-665-5p, mmu-miR-6769b-5p circRNA-miRNA predicted mmu_circRNA_40001 circRNA mus musculus focal cerebral ischemia 29156814 Screening circular RNA expression patterns following focal cerebral ischemia in mice. Liu C, Zhang C, Yang J, Geng X, Du H, Ji X, Zhao H. Oncotarget. 2017 Significantly upregulated in in the ischemic group microarray, qRT-PCR ischemic mouse brain, controls mmumiR-466f, mmu-miR-466i-5p, mmu-miR-669n, mmumiR-1187, and mmu-miR-466c-5p circRNA-miRNA predicted mmu_circRNA_013120 circRNA mus musculus focal cerebral ischemia 29156814 Screening circular RNA expression patterns following focal cerebral ischemia in mice. Liu C, Zhang C, Yang J, Geng X, Du H, Ji X, Zhao H. Oncotarget. 2017 Significantly upregulated in in the ischemic group microarray, qRT-PCR ischemic mouse brain, controls mmu-miR-6541, mmu-miR-669c-3p,mmu-miR-466f-5p, mmu-miR-669m-5p, and mmu-miR-466j circRNA-miRNA predicted mmu_circRNA_40806 circRNA mus musculus focal cerebral ischemia 29156814 Screening circular RNA expression patterns following focal cerebral ischemia in mice. Liu C, Zhang C, Yang J, Geng X, Du H, Ji X, Zhao H. Oncotarget. 2017 Significantly downregulated in in the ischemic group microarray, qRT-PCR ischemic mouse brain, controls mmu-miR-7038-3p, mmu-miR-20a-3p, mmu-miR-145a-3p, mmu-miR-346-3p, and mmu-miR-149-5p circRNA-miRNA predicted ciRS-7 circRNA mus musculus Cdr1 Cdr1as 26211738 The circular RNA Cdr1as, via miR-7 and its targets, regulates insulin transcription and secretion in islet cells. Xu H, Guo S, Li W, Yu P. Sci Rep. 2015 Cdr1as was found to express in MIN6 cells, mouse islets, brain, pituitary gland and AtT-20 cells. expressed in islet cells and was upregulated by long-term forskolin and PMA stimulation. qRT-PCR, sanger sequencing MIN6 cells, mouse islets, brain, pituitary gland and AtT-20 cells. Cdr1as increased insulin secretion. Both insulin content and secretion were significantly increased by overexpression of Cdr1as in islet cells. gain of function MIN6, AtT-20 Mouse islets miR-7 circRNA-miRNA MIN6, islets qRT-PCR Cdr1as upregulates miR-7 target genes expression. Myrip, Pax6 circ-Atxn7 circRNA mus musculus Atxn7 cardiovascular diseases 28676412 Identification of circular RNAs with host gene-independent expression in human model systems for cardiac differentiation and disease. Siede D, Rapti K, Gorska AA, Katus HA, Altmüller J, Boeckel JN, Meder B, Maack C, Völkers M, Müller OJ, Backs J, Dieterich C. J Mol Cell Cardiol. 2017 ribosomes circRNA-protein mouse cardiac myocytes RIP Figure 4C shows a cluster of 4 circular RNAs (Myocd, Slc8a1, Atxn7 and Phf21a) where we see an enrichment of BSJ reads (column 1-4) over linear spliced reads (column 5-8) in the ribosomal IP fraction (column 1-2 and 5-8). circ-Myocd circRNA mus musculus Myocd cardiovascular diseases 28676412 Identification of circular RNAs with host gene-independent expression in human model systems for cardiac differentiation and disease. Siede D, Rapti K, Gorska AA, Katus HA, Altmüller J, Boeckel JN, Meder B, Maack C, Völkers M, Müller OJ, Backs J, Dieterich C. J Mol Cell Cardiol. 2017 ribosomes circRNA-protein mouse cardiac myocytes RIP Figure 4C shows a cluster of 4 circular RNAs (Myocd, Slc8a1, Atxn7 and Phf21a) where we see an enrichment of BSJ reads (column 1-4) over linear spliced reads (column 5-8) in the ribosomal IP fraction (column 1-2 and 5-6). circ-Phf21a circRNA mus musculus Phf21a cardiovascular diseases 28676412 Identification of circular RNAs with host gene-independent expression in human model systems for cardiac differentiation and disease. Siede D, Rapti K, Gorska AA, Katus HA, Altmüller J, Boeckel JN, Meder B, Maack C, Völkers M, Müller OJ, Backs J, Dieterich C. J Mol Cell Cardiol. 2017 ribosomes circRNA-protein mouse cardiac myocytes RIP Figure 4C shows a cluster of 4 circular RNAs (Myocd, Slc8a1, Atxn7 and Phf21a) where we see an enrichment of BSJ reads (column 1-4) over linear spliced reads (column 5-8) in the ribosomal IP fraction (column 1-2 and 5-9). circ-Slc8a1 circRNA mus musculus Slc8a1 cardiovascular diseases 28676412 Identification of circular RNAs with host gene-independent expression in human model systems for cardiac differentiation and disease. Siede D, Rapti K, Gorska AA, Katus HA, Altmüller J, Boeckel JN, Meder B, Maack C, Völkers M, Müller OJ, Backs J, Dieterich C. J Mol Cell Cardiol. 2017 ribosomes circRNA-protein mouse cardiac myocytes RIP Figure 4C shows a cluster of 4 circular RNAs (Myocd, Slc8a1, Atxn7 and Phf21a) where we see an enrichment of BSJ reads (column 1-4) over linear spliced reads (column 5-8) in the ribosomal IP fraction (column 1-2 and 5-7). circ-Foxo3 circRNA mus musculus Foxo3 26861625 Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2. Du WW, Yang W, Liu E, Yang Z, Dhaliwal P, Yang BB. Nucleic Acids Res. 2016 highly expressed in non-cancer cells qRT-PCR, northern blots MEF, MCF, NIH3T3, 67NR, 66C14, 4T07, 4T1 and B16 Silencing endogenous circ-Foxo3 promoted cell proliferation. Ectopic expression of circ-Foxo3 repressed cell cycle progression by binding to the cell cycle proteins cyclin-dependent kinase 2 (also known as cell division protein kinase 2 or CDK2) and cyclin-dependent kinase inhibitor 1 (or p21), resulting in the formation of a ternary complex. loss of function, gain of function NIH3T3, B16 p21 and CDK2 circRNA-protein NIH3T3 RIP, RNA pull-down The experiment showed that circ-Foxo3 was pulled-down by immunoprecipitation experiments with antibodies against CDK2 and p21, which did not pull-down linear Foxo3 mRNA. p21 and CDK2 were pulleddown by the probe but not by the control oligo in the circ-Foxo3-transfected cells. circ-Foxo3 circRNA mus musculus Foxo3 26873092 Foxo3 circular RNA promotes cardiac senescence by modulating multiple factors associated with stress and senescence responses. Du WW, Yang W, Chen Y, Wu ZK, Foster FS, Yang Z, Li X, Yang BB. Eur Heart J. 2017 highly expressed in heart samples of aged patients and mice northern blots, RT-PCR, qRT-PCR, FISH MEF, primary cardiomyocytes ID-1, E2F1, FAK, and HIF1¦Á interact with circ-Foxo3 and are retained in the cytoplasm and could no longer exert their anti-senescent and anti-stress roles, resulting in increased cellular senescence. loss of function, gain of function MEF, primary cardiomyocytes 6¨C8 weeks, BALB/c strain ID1, E2F1, HIF1a, and FAK circRNA-protein MEF, primary cardiomyocytes RIP, RNA pull-down circ-Foxo3 was pulled down by antibodies against ID1, E2F1, FAK, and HIF1a, but the linear Foxo3 mRNA was not. It was found that circ-Foxo3 could pull down Id1, E2F1, HIF1a, and FAK from cells transfected with circ-Foxo3. MFACR circRNA mus musculus mm9-circ-016597 cardiovascular diseases 28498369 Circular RNA mediates cardiomyocyte death via miRNA-dependent upregulation of MTP18 expression. Wang K, Gan TY, Li N, Liu CY, Zhou LY, Gao JN, Chen C, Yan KW, Ponnusamy M, Zhang YH, Li PF. Cell Death Differ. 2017 MFACR was expressed in the mouse heart. qRT-PCR mouse cardiomyocyte MFACR regulates mitochondrial fission and apoptosis in the heart by directly targeting and downregulating miR-652-3p; this in turn blocks mitochondrial fission and cardiomyocyte cell death by suppressing MTP18 translation. MFACR directly sequesters miR-652-3p in the cytoplasm and inhibits its activity. MFACR knockdown in cardiomyocytes and mice attenuates mitochondrial fission and MI. loss of function, gain of function mouse cardiomyocyte mouse I/R injury model of MI miR-652-3p circRNA-miRNA mouse cardiomyocytes RNA pull-down these data indicate that MFACR can directly bind to miR-652-3p in vivo. MTP18 circRNA_000203 circRNA mus musculus Myo9a diabetic cardiomyopathy 28079129 CircRNA_000203 enhances the expression of fibrosis-associated genes by derepressing targets of miR-26b-5p, Col1a2 and CTGF, in cardiac fibroblasts. Tang CM, Zhang M, Huang L, Hu ZQ, Zhu JN, Xiao Z, Zhang Z, Lin QX, Zheng XL, -Yang M, Wu SL, Cheng JD, Shan ZX. Sci Rep. 2017 CircRNA_000203 was shown upregulated in the diabetic mouse myocardium and in Ang-II-induced mouse cardiac fibroblasts. qRT-PCR diabetic mouse myocardium Enforced-expression of circRNA_000203 could increase expressions of Col1a2, Col3a1 and ¦Á-SMA in mouse cardiac fibroblasts. over-expression of circRNA_000203 could eliminate the anti-fibrosis effect of miR-26b-5p in cardiac fibroblasts. gain of function mouse cardiac fibroblasts miR-26b-5p circRNA-miRNA HEK293 cells RNA pull-down, qRT-PCR RNA pull-down and RT-qPCR assay indicated that circRNA_000203 could specifically sponge miR-26b-5p. Col1a2 and CTGF chr10:5403841-5426275- circRNA mus musculus mm9_circ_001767 traumatic brain injury 29409384 Circular RNA expression alteration in exosomes from the brain extracellular space after traumatic brain injury in mice. Zhao R, Zhou J, Dong X, Bi C, Jiang R, Dong J, Tian Y, Yuan H, Zhang JN. J Neurotrauma. 2018 Significantly up-regulated in TBI group compared to Sham group. RNA-seq, qRT-PCR TBI group, Sham group chr5:115655901-115663886- circRNA mus musculus Ccdc64 traumatic brain injury 29409384 Circular RNA expression alteration in exosomes from the brain extracellular space after traumatic brain injury in mice. Zhao R, Zhou J, Dong X, Bi C, Jiang R, Dong J, Tian Y, Yuan H, Zhang JN. J Neurotrauma. 2018 Significantly down-regulated in TBI group compared to Sham group. RNA-seq, qRT-PCR TBI group, Sham group chrX: 143709648-143744001- circRNA mus musculus traumatic brain injury 29409384 Circular RNA expression alteration in exosomes from the brain extracellular space after traumatic brain injury in mice. Zhao R, Zhou J, Dong X, Bi C, Jiang R, Dong J, Tian Y, Yuan H, Zhang JN. J Neurotrauma. 2018 Significantly down-regulated in TBI group compared to Sham group. RNA-seq, qRT-PCR TBI group, Sham group chr12: 116871936-116901047- circRNA mus musculus Ptprn2 traumatic brain injury 29409384 Circular RNA expression alteration in exosomes from the brain extracellular space after traumatic brain injury in mice. Zhao R, Zhou J, Dong X, Bi C, Jiang R, Dong J, Tian Y, Yuan H, Zhang JN. J Neurotrauma. 2018 Significantly up-regulated in TBI group compared to Sham group. RNA-seq, qRT-PCR TBI group, Sham group circ-Stk35 circRNA mus musculus Stk35 mm9_circ_002813 aging 27958329 CircRNA accumulation in the aging mouse brain. Gruner H, Cortés-López M, Cooper DA, Bauer M, Miura P. Sci Rep. 2016 Increased expression between 22 mo versus 1 mo cortex samples was confirmed. RNA-seq, qRT-PCR 22 mo cortex, 1 mo cortex circ-Zfp609 circRNA mus musculus Zfp609 mm9_circ_004501 aging 27958329 CircRNA accumulation in the aging mouse brain. Gruner H, Cortés-López M, Cooper DA, Bauer M, Miura P. Sci Rep. 2016 Increased expression between 22 mo versus 1 mo cortex samples was confirmed. RNA-seq, qRT-PCR 22 mo cortex, 1 mo cortex circ-Samd4 circRNA mus musculus Samd4 mm9_circ_005305 aging 27958329 CircRNA accumulation in the aging mouse brain. Gruner H, Cortés-López M, Cooper DA, Bauer M, Miura P. Sci Rep. 2016 RT-qPCR indicated a significant ~2-fold upregulation of circ-Samd4 in the aged cortex sample RNA-seq, qRT-PCR 22 mo cortex, 1 mo cortex CDR1as circRNA mus musculus Cdr1 aging 27958329 CircRNA accumulation in the aging mouse brain. Gruner H, Cortés-López M, Cooper DA, Bauer M, Miura P. Sci Rep. 2016 Increased expression between 22 mo versus 1 mo cortex samples was confirmed. RNA-seq, qRT-PCR 22 mo cortex, 1 mo cortex circ-Trpc6 circRNA mus musculus Trpc6 mm9_circ_013636 aging 27958329 CircRNA accumulation in the aging mouse brain. Gruner H, Cortés-López M, Cooper DA, Bauer M, Miura P. Sci Rep. 2016 Increased expression between 22 mo versus 1 mo cortex samples was confirmed. significantly increased between 1 mo and 6 mo hippocampus. significantly increased between 6 mo and 22 mo hippocampus. RNA-seq, qRT-PCR 22 mo cortex, 1 mo cortex, 22 mo hippocampus, 6 mo hippocampus, 1 mo hippocampus. circ-INT circRNA mus musculus INT mm9_circ_017175 aging 27958329 CircRNA accumulation in the aging mouse brain. Gruner H, Cortés-López M, Cooper DA, Bauer M, Miura P. Sci Rep. 2016 Increased expression between 22 mo versus 1 mo cortex samples was confirmed. significantly increased between 1 mo and 6 mo hippocampus. significantly increased between 6 mo and 22 mo hippocampus. RNA-seq, qRT-PCR 22 mo cortex, 1 mo cortex, 22 mo hippocampus, 6 mo hippocampus, 1 mo hippocampus. circ-Ankib1 circRNA mus musculus Ankib1 mm9_circ_000903 aging 27958329 CircRNA accumulation in the aging mouse brain. Gruner H, Cortés-López M, Cooper DA, Bauer M, Miura P. Sci Rep. 2016 increased in 22 mo vs 1 mo cortex samples. Significantly increased at 6 mo compared to 1 mo. significantly increased between 6 mo and 22 mo hippocampus. RNA-seq, qRT-PCR 22 mo cortex, 6 mo cortex, 1 mo cortex, 22 mo hippocampus, 6 mo hippocampus, 1 mo hippocampus. m001237 circRNA mus musculus Ogdh 27476877 Characterization of circular RNAs in human, mouse and rat hearts. Werfel S, Nothjunge S, Schwarzmayr T, Strom TM, Meitinger T, Engelhardt S. J Mol Cell Cardiol. 2016 To further confirm the circularity of select candidates we quantified their enrichment in RNase R treated vs. mock treated samples using qPCR. We observed that circRNAs with higher predicted lengths showed lower enrichment, possibly due to minimal endonuclease contamination or small degree of RNA degradation during or after RNA isolation (m004295: 1.8 kb, m005505: 6.2 kb, m005504: 6,5 kb vs. m001237: 0.4 kb, m003757: 0.6 kb). qRT-PCR adult mouse heart m003757 circRNA mus musculus Lrch3 27476877 Characterization of circular RNAs in human, mouse and rat hearts. Werfel S, Nothjunge S, Schwarzmayr T, Strom TM, Meitinger T, Engelhardt S. J Mol Cell Cardiol. 2016 To further confirm the circularity of select candidates we quantified their enrichment in RNase R treated vs. mock treated samples using qPCR. We observed that circRNAs with higher predicted lengths showed lower enrichment, possibly due to minimal endonuclease contamination or small degree of RNA degradation during or after RNA isolation (m004295: 1.8 kb, m005505: 6.2 kb, m005504: 6,5 kb vs. m001237: 0.4 kb, m003757: 0.6 kb). qRT-PCR adult mouse heart m004295 circRNA mus musculus Slc8a1 27476877 Characterization of circular RNAs in human, mouse and rat hearts. Werfel S, Nothjunge S, Schwarzmayr T, Strom TM, Meitinger T, Engelhardt S. J Mol Cell Cardiol. 2016 To further confirm the circularity of select candidates we quantified their enrichment in RNase R treated vs. mock treated samples using qPCR. We observed that circRNAs with higher predicted lengths showed lower enrichment, possibly due to minimal endonuclease contamination or small degree of RNA degradation during or after RNA isolation (m004295: 1.8 kb, m005505: 6.2 kb, m005504: 6,5 kb vs. m001237: 0.4 kb, m003757: 0.6 kb). qRT-PCR adult mouse heart m005504 circRNA mus musculus Ttn 27476877 Characterization of circular RNAs in human, mouse and rat hearts. Werfel S, Nothjunge S, Schwarzmayr T, Strom TM, Meitinger T, Engelhardt S. J Mol Cell Cardiol. 2016 To further confirm the circularity of select candidates we quantified their enrichment in RNase R treated vs. mock treated samples using qPCR. We observed that circRNAs with higher predicted lengths showed lower enrichment, possibly due to minimal endonuclease contamination or small degree of RNA degradation during or after RNA isolation (m004295: 1.8 kb, m005505: 6.2 kb, m005504: 6,5 kb vs. m001237: 0.4 kb, m003757: 0.6 kb). qRT-PCR adult mouse heart m005505 circRNA mus musculus Ttn 27476877 Characterization of circular RNAs in human, mouse and rat hearts. Werfel S, Nothjunge S, Schwarzmayr T, Strom TM, Meitinger T, Engelhardt S. J Mol Cell Cardiol. 2016 To further confirm the circularity of select candidates we quantified their enrichment in RNase R treated vs. mock treated samples using qPCR. We observed that circRNAs with higher predicted lengths showed lower enrichment, possibly due to minimal endonuclease contamination or small degree of RNA degradation during or after RNA isolation (m004295: 1.8 kb, m005505: 6.2 kb, m005504: 6,5 kb vs. m001237: 0.4 kb, m003757: 0.6 kb). qRT-PCR adult mouse heart circRNA.19236 circRNA mus musculus osteoblast differentiation 28395271 Differential circRNA expression profiles during the BMP2-induced osteogenic differentiation of MC3T3-E1 cells. Qian DY, Yan GB, Bai B, Chen Y, Zhang SJ, Yao YC, Xia H. Biomed Pharmacother. 2017 Increased in the BMP2-treated MC3T3-E1 cells. RNA-seq, qRT-PCR BMP2-treated MC3T3-E1 cells, control MC3T3-E1 cells circRNA.10042 circRNA mus musculus osteoblast differentiation 28395271 Differential circRNA expression profiles during the BMP2-induced osteogenic differentiation of MC3T3-E1 cells. Qian DY, Yan GB, Bai B, Chen Y, Zhang SJ, Yao YC, Xia H. Biomed Pharmacother. 2017 Significantly increased in the BMP2-treated MC3T3-E1 cells. RNA-seq, qRT-PCR BMP2-treated MC3T3-E1 cells, control MC3T3-E1 cells circRNA.19142 circRNA mus musculus osteoblast differentiation 28395271 Differential circRNA expression profiles during the BMP2-induced osteogenic differentiation of MC3T3-E1 cells. Qian DY, Yan GB, Bai B, Chen Y, Zhang SJ, Yao YC, Xia H. Biomed Pharmacother. 2017 Significantly increased in the BMP2-treated MC3T3-E1 cells. RNA-seq, qRT-PCR BMP2-treated MC3T3-E1 cells, control MC3T3-E1 cells circRNA.5846 circRNA mus musculus osteoblast differentiation 28395271 Differential circRNA expression profiles during the BMP2-induced osteogenic differentiation of MC3T3-E1 cells. Qian DY, Yan GB, Bai B, Chen Y, Zhang SJ, Yao YC, Xia H. Biomed Pharmacother. 2017 Significantly increased in the BMP2-treated MC3T3-E1 cells. RNA-seq, qRT-PCR BMP2-treated MC3T3-E1 cells, control MC3T3-E1 cells ciHnrnpu circRNA mus musculus Hnrnpu psychiatric disease 27113499 A Comprehensive Analysis of Cell Type-Specific Nuclear RNA From Neurons and Glia of the Brain. Reddy AS, OBrien D, Pisat N, Weichselbaum CT, Sakers K, Lisci M, Dalal JS, Dougherty JD. Biol Psychiatry. 2017 enriched in nuclei relative to cytoplasm and is found throughout the brain. qRT-PCR Cortex, Cerebellum, Forebrain/Midbrain, Hindbrain of mouse mmu_circRNA_003540 circRNA mus musculus Alzheimer¡¯s disease 29448241 Comprehensive analysis of differentially expressed profiles of Alzheimers disease associated circular RNAs in an Alzheimers disease mouse model. Huang JL, Qin MC, Zhou Y, Xu ZH, Yang SM, Zhang F, Zhong J, Liang MK, Chen B, Zhang WY, Wu DP, Zhong ZG. Aging (Albany NY). 2018 Significantly differed between the hippocampal tissues of 10-month-old SAMP8 and age-matched SAMR1 (P<0.05) microarray, qRT-PCR hippocampal tissues of 10-month-old SAMP8 and age-matched SAMR1 mmu_circRNA_006173 circRNA mus musculus Alzheimer¡¯s disease 29448241 Comprehensive analysis of differentially expressed profiles of Alzheimers disease associated circular RNAs in an Alzheimers disease mouse model. Huang JL, Qin MC, Zhou Y, Xu ZH, Yang SM, Zhang F, Zhong J, Liang MK, Chen B, Zhang WY, Wu DP, Zhong ZG. Aging (Albany NY). 2018 Significantly differed between the hippocampal tissues of 10-month-old SAMP8 and age-matched SAMR1 (P<0.05) microarray, qRT-PCR hippocampal tissues of 10-month-old SAMP8 and age-matched SAMR1 mmu_circRNA_012180 circRNA mus musculus Alzheimer¡¯s disease 29448241 Comprehensive analysis of differentially expressed profiles of Alzheimers disease associated circular RNAs in an Alzheimers disease mouse model. Huang JL, Qin MC, Zhou Y, Xu ZH, Yang SM, Zhang F, Zhong J, Liang MK, Chen B, Zhang WY, Wu DP, Zhong ZG. Aging (Albany NY). 2018 Significantly differed between the hippocampal tissues of 10-month-old SAMP8 and age-matched SAMR1 (P<0.05) microarray, qRT-PCR hippocampal tissues of 10-month-old SAMP8 and age-matched SAMR1 mmu_circRNA_013699 circRNA mus musculus Alzheimer¡¯s disease 29448241 Comprehensive analysis of differentially expressed profiles of Alzheimers disease associated circular RNAs in an Alzheimers disease mouse model. Huang JL, Qin MC, Zhou Y, Xu ZH, Yang SM, Zhang F, Zhong J, Liang MK, Chen B, Zhang WY, Wu DP, Zhong ZG. Aging (Albany NY). 2018 Significantly differed between the hippocampal tissues of 10-month-old SAMP8 and age-matched SAMR1 (P<0.05) microarray, qRT-PCR hippocampal tissues of 10-month-old SAMP8 and age-matched SAMR1 mmu_circRNA_017963 circRNA mus musculus Alzheimer¡¯s disease 29448241 Comprehensive analysis of differentially expressed profiles of Alzheimers disease associated circular RNAs in an Alzheimers disease mouse model. Huang JL, Qin MC, Zhou Y, Xu ZH, Yang SM, Zhang F, Zhong J, Liang MK, Chen B, Zhang WY, Wu DP, Zhong ZG. Aging (Albany NY). 2018 Significantly differed between the hippocampal tissues of 10-month-old SAMP8 and age-matched SAMR1 (P<0.05) microarray, qRT-PCR hippocampal tissues of 10-month-old SAMP8 and age-matched SAMR1 chr11:29705535|29708770 circRNA mus musculus Rtn4 29253603 Region-specific expression of circular RNAs in the mouse brain. Chen BJ, Yang B, Janitz M. Neurosci Lett. 2018 Experimental validation, using RT-qPCR and independent RNA sample set, of the differentially expressed circRNA between hippocampus and frontal cortex, corroborated outcomes of the RNA-Seq data analysis RNA-seq, qRT-PCR hippocampus (HC) and prefrontal cortex (PFC) of mouse brain chr3:122781567|122818067 circRNA mus musculus Pde5a 29253603 Region-specific expression of circular RNAs in the mouse brain. Chen BJ, Yang B, Janitz M. Neurosci Lett. 2018 Experimental validation, using RT-qPCR and independent RNA sample set, of the differentially expressed circRNA between hippocampus and frontal cortex, corroborated outcomes of the RNA-Seq data analysis RNA-seq, qRT-PCR hippocampus (HC) and prefrontal cortex (PFC) of mouse brain chr4:13835633|13846957 circRNA mus musculus Runx1t1 29253603 Region-specific expression of circular RNAs in the mouse brain. Chen BJ, Yang B, Janitz M. Neurosci Lett. 2018 Experimental validation, using RT-qPCR and independent RNA sample set, of the differentially expressed circRNA between hippocampus and frontal cortex, corroborated outcomes of the RNA-Seq data analysis RNA-seq, qRT-PCR hippocampus (HC) and prefrontal cortex (PFC) of mouse brain circ-Ttn circRNA mus musculus Ttn Doxorubicin-Mediated Cardiotoxicity 29133306 Quaking Inhibits Doxorubicin-Mediated Cardiotoxicity Through Regulation of Cardiac Circular RNA Expression. Gupta SK, Garg A, Bär C, Chatterjee S, Foinquinos A, Milting H, StreckfuÃb-Bomeke K, Fiedler J, Thum T. Circ Res. 2018 Significantly changed in pLV (plasmid Lentivirus) empty, pLV Qki5, CRi empty, CRi 3+4 Qki, and CRi 5+6 Qki HL-1 cell lines. Positively regulated with Qki expression. Downregulated with doxorubicin treatment in HL-1 cells. Downregulated in mouse hearts, which had doxorubicin-induced reductions in Qki levels. Downregulated in control (pLV empty) cells exposed to doxorubicin compared with pLV Qki5-overexpressing cells. qRT-PCR HL-1 cell lines we inhibited Ttn 105¨C111 circular RNA by a specific siRNA approach (Figure 3G) and evaluated its effect on doxorubicin-induced apoptosis. SiRNA mediated inhibition of Ttn 105¨C111 led to increased susceptibility to doxorubicin as evident by higher caspase activity. Additionally, the knockdown of Ttn 105¨C111 in pLV Qki5-overexpressing cell line also resulted in an induced caspase activity. On the contrary, lentiviral mediated overexpression of circular RNA Ttn 105¨C111 resulted in lower caspase 3/7 activity and increased survival as seen by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay (Online Figure IVD though IVF). loss of function, gain of function HL-1 cell lines circArhgap32 circRNA mus musculus Arhgap32 Doxorubicin-Mediated Cardiotoxicity 29133306 Quaking Inhibits Doxorubicin-Mediated Cardiotoxicity Through Regulation of Cardiac Circular RNA Expression. Gupta SK, Garg A, Bär C, Chatterjee S, Foinquinos A, Milting H, Streckfub-Bomeke K, Fiedler J, Thum T. Circ Res. 2018 Significantly changed in pLV (plasmid Lentivirus) empty, pLV Qki5, CRi empty, CRi 3+4 Qki, and CRi 5+6 Qki HL-1 cell lines. Negtively regulated with Qki expression. Downregulated with doxorubicin treatment in HL-1 cells. qRT-PCR HL-1 cell lines circ-Strn3 circRNA mus musculus Strn3 Doxorubicin-Mediated Cardiotoxicity 29133306 Quaking Inhibits Doxorubicin-Mediated Cardiotoxicity Through Regulation of Cardiac Circular RNA Expression. Gupta SK, Garg A, Bär C, Chatterjee S, Foinquinos A, Milting H, StreckfuÃb-Bomeke K, Fiedler J, Thum T. Circ Res. 2018 Significantly changed in pLV (plasmid Lentivirus) empty, pLV Qki5, CRi empty, CRi 3+4 Qki, and CRi 5+6 Qki HL-1 cell lines. Positively regulated with Qki expression. Downregulated with doxorubicin treatment in HL-1 cells. Downregulated in mouse hearts, which had doxorubicin-induced reductions in Qki levels. Downregulated in control (pLV empty) cells exposed to doxorubicin compared with pLV Qki5-overexpressing cells. qRT-PCR HL-1 cell lines circ-Fhod3 circRNA mus musculus Fhod3 Doxorubicin-Mediated Cardiotoxicity 29133306 Quaking Inhibits Doxorubicin-Mediated Cardiotoxicity Through Regulation of Cardiac Circular RNA Expression. Gupta SK, Garg A, Bär C, Chatterjee S, Foinquinos A, Milting H, StreckfuÃb-Bomeke K, Fiedler J, Thum T. Circ Res. 2018 Significantly changed in pLV (plasmid Lentivirus) empty, pLV Qki5, CRi empty, CRi 3+4 Qki, and CRi 5+6 Qki HL-1 cell lines. Positively regulated with Qki expression. Downregulated with doxorubicin treatment in HL-1 cells. Downregulated in mouse hearts, which had doxorubicin-induced reductions in Qki levels. Downregulated in control (pLV empty) cells exposed to doxorubicin compared with pLV Qki5-overexpressing cells. qRT-PCR HL-1 cell lines mmu-circRNA-015947 circRNA mus musculus 26845359 Circular RNA expression alterations are involved in OGD/R-induced neuron injury. Lin SP, Ye S, Long Y, Fan Y, Mao HF, Chen MT, Ma QJ. Biochem Biophys Res Commun. 2016 up-regulated in the OGD/R group microarray, qRT-PCR HT22, OGD/R HT22 cells circRNA.2483 circRNA mus musculus Osteoarthritis 29247798 Circular RNA expression profile of articular chondrocytes in an IL-1β-induced mouse model of osteoarthritis. Zhou Z, Du D, Chen A, Zhu L. Gene. 2018 Down-regulated in IL-1¦Â-induced mouse articular chondrocytes compared to controls. RNA-seq, qRT-PCR IL-1¦Â-induced mouse articular chondrocytes, controls circRNA.33736 circRNA mus musculus Osteoarthritis 29247798 Circular RNA expression profile of articular chondrocytes in an IL-1β-induced mouse model of osteoarthritis. Zhou Z, Du D, Chen A, Zhu L. Gene. 2018 Down-regulated in IL-1¦Â-induced mouse articular chondrocytes compared to controls. RNA-seq, qRT-PCR IL-1¦Â-induced mouse articular chondrocytes, controls circRNA.2443 circRNA mus musculus Osteoarthritis 29247798 Circular RNA expression profile of articular chondrocytes in an IL-1β-induced mouse model of osteoarthritis. Zhou Z, Du D, Chen A, Zhu L. Gene. 2018 Up-regulated in IL-1¦Â-induced mouse articular chondrocytes compared to controls. RNA-seq, qRT-PCR IL-1¦Â-induced mouse articular chondrocytes, controls circRNA.33186 circRNA mus musculus Osteoarthritis 29247798 Circular RNA expression profile of articular chondrocytes in an IL-1β-induced mouse model of osteoarthritis. Zhou Z, Du D, Chen A, Zhu L. Gene. 2018 Up-regulated in IL-1¦Â-induced mouse articular chondrocytes compared to controls. RNA-seq, qRT-PCR IL-1¦Â-induced mouse articular chondrocytes, controls circRNA.7063 circRNA mus musculus Osteoarthritis 29247798 Circular RNA expression profile of articular chondrocytes in an IL-1β-induced mouse model of osteoarthritis. Zhou Z, Du D, Chen A, Zhu L. Gene. 2018 Up-regulated in IL-1¦Â-induced mouse articular chondrocytes compared to controls. RNA-seq, qRT-PCR IL-1¦Â-induced mouse articular chondrocytes, controls c-13 circRNA mus musculus circ_0273 amyotrophic lateral sclerosis 28358055 FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons. Errichelli L, Dini Modigliani S, Laneve P, Colantoni A, Legnini I, Capauto D, Rosa A, De Santis R, Scarfò R, Peruzzi G, Lu L, Caffarelli E, Shneider NA, Morlando M, Bozzoni I. Nat Commun. 2017 The expression of the circRNA was then measured by quantitative RT¨CPCR in GFP+-FUS+/+ and GFP+-FUS-/- MNs and all of them resulted significantly deregulated, in agreement with RNA-seq in FUS-/- conditions. RNA-seq, qRT-PCR in vitro-derived mouse motor neurons c-75 circRNA mus musculus circ_0907 amyotrophic lateral sclerosis 28358055 FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons. Errichelli L, Dini Modigliani S, Laneve P, Colantoni A, Legnini I, Capauto D, Rosa A, De Santis R, Scarfò R, Peruzzi G, Lu L, Caffarelli E, Shneider NA, Morlando M, Bozzoni I. Nat Commun. 2017 The expression of the circRNA was then measured by quantitative RT¨CPCR in GFP+-FUS+/+ and GFP+-FUS-/- MNs and all of them resulted significantly deregulated, in agreement with RNA-seq in FUS-/- conditions. RNA-seq, qRT-PCR in vitro-derived mouse motor neurons c-76 circRNA mus musculus circ_0919 amyotrophic lateral sclerosis 28358055 FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons. Errichelli L, Dini Modigliani S, Laneve P, Colantoni A, Legnini I, Capauto D, Rosa A, De Santis R, Scarfò R, Peruzzi G, Lu L, Caffarelli E, Shneider NA, Morlando M, Bozzoni I. Nat Commun. 2017 The expression of the circRNA was then measured by quantitative RT¨CPCR in GFP+-FUS+/+ and GFP+-FUS-/- MNs and all of them resulted significantly deregulated, in agreement with RNA-seq in FUS-/- conditions. RNA-seq, qRT-PCR in vitro-derived mouse motor neurons c-77 circRNA mus musculus circ_0920 amyotrophic lateral sclerosis 28358055 FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons. Errichelli L, Dini Modigliani S, Laneve P, Colantoni A, Legnini I, Capauto D, Rosa A, De Santis R, Scarfò R, Peruzzi G, Lu L, Caffarelli E, Shneider NA, Morlando M, Bozzoni I. Nat Commun. 2017 The expression of the circRNA was then measured by quantitative RT¨CPCR in GFP+-FUS+/+ and GFP+-FUS-/- MNs and all of them resulted significantly deregulated, in agreement with RNA-seq in FUS-/- conditions. RNA-seq, qRT-PCR in vitro-derived mouse motor neurons c-27 circRNA mus musculus circ_1165 amyotrophic lateral sclerosis 28358055 FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons. Errichelli L, Dini Modigliani S, Laneve P, Colantoni A, Legnini I, Capauto D, Rosa A, De Santis R, Scarfò R, Peruzzi G, Lu L, Caffarelli E, Shneider NA, Morlando M, Bozzoni I. Nat Commun. 2017 The expression of the circRNA was then measured by quantitative RT¨CPCR in GFP+-FUS+/+ and GFP+-FUS-/- MNs and all of them resulted significantly deregulated, in agreement with RNA-seq in FUS-/- conditions. RNA-seq, qRT-PCR in vitro-derived mouse motor neurons c-02 circRNA mus musculus circ_1223 amyotrophic lateral sclerosis 28358055 FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons. Errichelli L, Dini Modigliani S, Laneve P, Colantoni A, Legnini I, Capauto D, Rosa A, De Santis R, Scarfò R, Peruzzi G, Lu L, Caffarelli E, Shneider NA, Morlando M, Bozzoni I. Nat Commun. 2017 The expression of the circRNA was then measured by quantitative RT¨CPCR in GFP+-FUS+/+ and GFP+-FUS-/- MNs and all of them resulted significantly deregulated, in agreement with RNA-seq in FUS-/- conditions. RNA-seq, qRT-PCR in vitro-derived mouse motor neurons c-88 circRNA mus musculus circ_1224 amyotrophic lateral sclerosis 28358055 FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons. Errichelli L, Dini Modigliani S, Laneve P, Colantoni A, Legnini I, Capauto D, Rosa A, De Santis R, Scarfò R, Peruzzi G, Lu L, Caffarelli E, Shneider NA, Morlando M, Bozzoni I. Nat Commun. 2017 The expression of the circRNA was then measured by quantitative RT¨CPCR in GFP+-FUS+/+ and GFP+-FUS-/- MNs and all of them resulted significantly deregulated, in agreement with RNA-seq in FUS-/- conditions. RNA-seq, qRT-PCR in vitro-derived mouse motor neurons c-48 circRNA mus musculus circ_1733 amyotrophic lateral sclerosis 28358055 FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons. Errichelli L, Dini Modigliani S, Laneve P, Colantoni A, Legnini I, Capauto D, Rosa A, De Santis R, Scarfò R, Peruzzi G, Lu L, Caffarelli E, Shneider NA, Morlando M, Bozzoni I. Nat Commun. 2017 The expression of the circRNA was then measured by quantitative RT¨CPCR in GFP+-FUS+/+ and GFP+-FUS-/- MNs and all of them resulted significantly deregulated, in agreement with RNA-seq in FUS-/- conditions. RNA-seq, qRT-PCR in vitro-derived mouse motor neurons c-78 circRNA mus musculus circ_2111 amyotrophic lateral sclerosis 28358055 FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons. Errichelli L, Dini Modigliani S, Laneve P, Colantoni A, Legnini I, Capauto D, Rosa A, De Santis R, Scarfò R, Peruzzi G, Lu L, Caffarelli E, Shneider NA, Morlando M, Bozzoni I. Nat Commun. 2017 The expression of the circRNA was then measured by quantitative RT¨CPCR in GFP+-FUS+/+ and GFP+-FUS-/- MNs and all of them resulted significantly deregulated, in agreement with RNA-seq in FUS-/- conditions. RNA-seq, qRT-PCR in vitro-derived mouse motor neurons c-79 circRNA mus musculus circ_2193 amyotrophic lateral sclerosis 28358055 FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons. Errichelli L, Dini Modigliani S, Laneve P, Colantoni A, Legnini I, Capauto D, Rosa A, De Santis R, Scarfò R, Peruzzi G, Lu L, Caffarelli E, Shneider NA, Morlando M, Bozzoni I. Nat Commun. 2017 The expression of the circRNA was then measured by quantitative RT¨CPCR in GFP+-FUS+/+ and GFP+-FUS-/- MNs and all of them resulted significantly deregulated, in agreement with RNA-seq in FUS-/- conditions. RNA-seq, qRT-PCR in vitro-derived mouse motor neurons c-84 circRNA mus musculus circ_2254 amyotrophic lateral sclerosis 28358055 FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons. Errichelli L, Dini Modigliani S, Laneve P, Colantoni A, Legnini I, Capauto D, Rosa A, De Santis R, Scarfò R, Peruzzi G, Lu L, Caffarelli E, Shneider NA, Morlando M, Bozzoni I. Nat Commun. 2017 The expression of the circRNA was then measured by quantitative RT¨CPCR in GFP+-FUS+/+ and GFP+-FUS-/- MNs and all of them resulted significantly deregulated, in agreement with RNA-seq in FUS-/- conditions. RNA-seq, qRT-PCR in vitro-derived mouse motor neurons c-82 circRNA mus musculus circ_3217 amyotrophic lateral sclerosis 28358055 FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons. Errichelli L, Dini Modigliani S, Laneve P, Colantoni A, Legnini I, Capauto D, Rosa A, De Santis R, Scarfò R, Peruzzi G, Lu L, Caffarelli E, Shneider NA, Morlando M, Bozzoni I. Nat Commun. 2017 The expression of the circRNA was then measured by quantitative RT¨CPCR in GFP+-FUS+/+ and GFP+-FUS-/- MNs and all of them resulted significantly deregulated, in agreement with RNA-seq in FUS-/- conditions. RNA-seq, qRT-PCR in vitro-derived mouse motor neurons c-01 circRNA mus musculus circ_3279 amyotrophic lateral sclerosis 28358055 FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons. Errichelli L, Dini Modigliani S, Laneve P, Colantoni A, Legnini I, Capauto D, Rosa A, De Santis R, Scarfò R, Peruzzi G, Lu L, Caffarelli E, Shneider NA, Morlando M, Bozzoni I. Nat Commun. 2017 The expression of the circRNA was then measured by quantitative RT¨CPCR in GFP+-FUS+/+ and GFP+-FUS-/- MNs and all of them resulted significantly deregulated, in agreement with RNA-seq in FUS-/- conditions. RNA-seq, qRT-PCR in vitro-derived mouse motor neurons c-83 circRNA mus musculus circ_3834 amyotrophic lateral sclerosis 28358055 FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons. Errichelli L, Dini Modigliani S, Laneve P, Colantoni A, Legnini I, Capauto D, Rosa A, De Santis R, Scarfò R, Peruzzi G, Lu L, Caffarelli E, Shneider NA, Morlando M, Bozzoni I. Nat Commun. 2017 The expression of the circRNA was then measured by quantitative RT¨CPCR in GFP+-FUS+/+ and GFP+-FUS-/- MNs and all of them resulted significantly deregulated, in agreement with RNA-seq in FUS-/- conditions. RNA-seq, qRT-PCR in vitro-derived mouse motor neurons c-80 circRNA mus musculus circ_4484 amyotrophic lateral sclerosis 28358055 FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons. Errichelli L, Dini Modigliani S, Laneve P, Colantoni A, Legnini I, Capauto D, Rosa A, De Santis R, Scarfò R, Peruzzi G, Lu L, Caffarelli E, Shneider NA, Morlando M, Bozzoni I. Nat Commun. 2017 The expression of the circRNA was then measured by quantitative RT¨CPCR in GFP+-FUS+/+ and GFP+-FUS-/- MNs and all of them resulted significantly deregulated, in agreement with RNA-seq in FUS-/- conditions. RNA-seq, qRT-PCR in vitro-derived mouse motor neurons c-87 circRNA mus musculus circ_5306 amyotrophic lateral sclerosis 28358055 FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons. Errichelli L, Dini Modigliani S, Laneve P, Colantoni A, Legnini I, Capauto D, Rosa A, De Santis R, Scarfò R, Peruzzi G, Lu L, Caffarelli E, Shneider NA, Morlando M, Bozzoni I. Nat Commun. 2017 The expression of the circRNA was then measured by quantitative RT¨CPCR in GFP+-FUS+/+ and GFP+-FUS-/- MNs and all of them resulted significantly deregulated, in agreement with RNA-seq in FUS-/- conditions. RNA-seq, qRT-PCR in vitro-derived mouse motor neurons c-45 circRNA mus musculus circ_5313 amyotrophic lateral sclerosis 28358055 FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons. Errichelli L, Dini Modigliani S, Laneve P, Colantoni A, Legnini I, Capauto D, Rosa A, De Santis R, Scarfò R, Peruzzi G, Lu L, Caffarelli E, Shneider NA, Morlando M, Bozzoni I. Nat Commun. 2017 The expression of the circRNA was then measured by quantitative RT¨CPCR in GFP+-FUS+/+ and GFP+-FUS-/- MNs and all of them resulted significantly deregulated, in agreement with RNA-seq in FUS-/- conditions. RNA-seq, qRT-PCR in vitro-derived mouse motor neurons c-52 circRNA mus musculus circ_5622 amyotrophic lateral sclerosis 28358055 FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons. Errichelli L, Dini Modigliani S, Laneve P, Colantoni A, Legnini I, Capauto D, Rosa A, De Santis R, Scarfò R, Peruzzi G, Lu L, Caffarelli E, Shneider NA, Morlando M, Bozzoni I. Nat Commun. 2017 The expression of the circRNA was then measured by quantitative RT¨CPCR in GFP+-FUS+/+ and GFP+-FUS-/- MNs and all of them resulted significantly deregulated, in agreement with RNA-seq in FUS-/- conditions. RNA-seq, qRT-PCR in vitro-derived mouse motor neurons c-31 circRNA mus musculus circ_5722 amyotrophic lateral sclerosis 28358055 FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons. Errichelli L, Dini Modigliani S, Laneve P, Colantoni A, Legnini I, Capauto D, Rosa A, De Santis R, Scarfò R, Peruzzi G, Lu L, Caffarelli E, Shneider NA, Morlando M, Bozzoni I. Nat Commun. 2017 The expression of the circRNA was then measured by quantitative RT¨CPCR in GFP+-FUS+/+ and GFP+-FUS-/- MNs and all of them resulted significantly deregulated, in agreement with RNA-seq in FUS-/- conditions. RNA-seq, qRT-PCR in vitro-derived mouse motor neurons c-03 circRNA mus musculus circ_5846 amyotrophic lateral sclerosis 28358055 FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons. Errichelli L, Dini Modigliani S, Laneve P, Colantoni A, Legnini I, Capauto D, Rosa A, De Santis R, Scarfò R, Peruzzi G, Lu L, Caffarelli E, Shneider NA, Morlando M, Bozzoni I. Nat Commun. 2017 The expression of the circRNA was then measured by quantitative RT¨CPCR in GFP+-FUS+/+ and GFP+-FUS-/- MNs and all of them resulted significantly deregulated, in agreement with RNA-seq in FUS-/- conditions. RNA-seq, qRT-PCR in vitro-derived mouse motor neurons c-16 circRNA mus musculus circ_5906 amyotrophic lateral sclerosis 28358055 FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons. Errichelli L, Dini Modigliani S, Laneve P, Colantoni A, Legnini I, Capauto D, Rosa A, De Santis R, Scarfò R, Peruzzi G, Lu L, Caffarelli E, Shneider NA, Morlando M, Bozzoni I. Nat Commun. 2017 The expression of the circRNA was then measured by quantitative RT¨CPCR in GFP+-FUS+/+ and GFP+-FUS-/- MNs and all of them resulted significantly deregulated, in agreement with RNA-seq in FUS-/- conditions. RNA-seq, qRT-PCR in vitro-derived mouse motor neurons circ_001729 circRNA mus musculus Transient Focal Ischemia 28701578 Circular RNA Expression Profiles Alter Significantly in Mouse Brain After Transient Focal Ischemia. Mehta SL, Pandi G, Vemuganti R. Stroke. 2017 The circRNAs circ_001729 was observed to be downregulated significantly at 6 hours reperfusion after transient MCAO compared with sham similar to the microarray data. microarray, qRT-PCR male C57BL/6J mice brain circ_006696 circRNA mus musculus Transient Focal Ischemia 28701578 Circular RNA Expression Profiles Alter Significantly in Mouse Brain After Transient Focal Ischemia. Mehta SL, Pandi G, Vemuganti R. Stroke. 2017 The circRNAs circ_006696 was observed to be downregulated significantly at 6 hours reperfusion after transient MCAO compared with sham similar to the microarray data. microarray, qRT-PCR male C57BL/6J mice brain circ_008018 circRNA mus musculus Transient Focal Ischemia 28701578 Circular RNA Expression Profiles Alter Significantly in Mouse Brain After Transient Focal Ischemia. Mehta SL, Pandi G, Vemuganti R. Stroke. 2017 The circRNAs circ_008018 was observed to be upregulated significantly at 6 hours reperfusion after transient MCAO compared with sham similar to the microarray data. microarray, qRT-PCR male C57BL/6J mice brain circ_011137 circRNA mus musculus Transient Focal Ischemia 28701578 Circular RNA Expression Profiles Alter Significantly in Mouse Brain After Transient Focal Ischemia. Mehta SL, Pandi G, Vemuganti R. Stroke. 2017 The circRNAs circ_011137 was observed to be downregulated significantly at 6 hours reperfusion after transient MCAO compared with sham similar to the microarray data. microarray, qRT-PCR male C57BL/6J mice brain circ_015350 circRNA mus musculus Transient Focal Ischemia 28701578 Circular RNA Expression Profiles Alter Significantly in Mouse Brain After Transient Focal Ischemia. Mehta SL, Pandi G, Vemuganti R. Stroke. 2017 The circRNAs circ_015350 was observed to be upregulated significantly at 6 hours reperfusion after transient MCAO compared with sham similar to the microarray data. microarray, qRT-PCR male C57BL/6J mice brain circ_016128 circRNA mus musculus Transient Focal Ischemia 28701578 Circular RNA Expression Profiles Alter Significantly in Mouse Brain After Transient Focal Ischemia. Mehta SL, Pandi G, Vemuganti R. Stroke. 2017 The circRNAs circ_016128 was observed to be upregulated significantly at 6 hours reperfusion after transient MCAO compared with sham similar to the microarray data. microarray, qRT-PCR male C57BL/6J mice brain circ-Foxo3 circRNA mus musculus Foxo3 27713910 The anti-cancer components of Ganoderma lucidum possesses cardiovascular protective effect by regulating circular RNA expression. Xie YZ, Yang F, Tan W, Li X, Jiao C, Huang R, Yang BB. Oncoscience. 2016 Treatment with Ganoderma spore oil decreases expression of circ-Foxo3 qRT-PCR mice orally delivered with Ganoderma spore oil (GSO), Mouse cardiac fibroblasts treated with different concentrations of GSO cdr1AS circRNA mus musculus Cdr1 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency. Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, Loewer A, Ziebold U, Landthaler M, Kocks C, le Noble F, Rajewsky N. Nature. 2013 The circRNA was validated experimentally. qRT-PCR, sanger sequencing mouse adult brain mus-circAFF1 circRNA mus musculus AFF1 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency. Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, Loewer A, Ziebold U, Landthaler M, Kocks C, le Noble F, Rajewsky N. Nature. 2013 The circRNA was validated experimentally. qRT-PCR, sanger sequencing mouse adult brain mus-circHIPK3 circRNA mus musculus HIPK3 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency. Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, Loewer A, Ziebold U, Landthaler M, Kocks C, le Noble F, Rajewsky N. Nature. 2013 The circRNA was validated experimentally. qRT-PCR, sanger sequencing mouse adult brain mus-circLRP6 circRNA mus musculus LRP6 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency. Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, Loewer A, Ziebold U, Landthaler M, Kocks C, le Noble F, Rajewsky N. Nature. 2013 The circRNA was validated experimentally. qRT-PCR, sanger sequencing mouse adult brain circFmn circRNA mus musculus Fmn 9848078 The mouse formin (Fmn) gene: abundant circular RNA transcripts and gene-targeted deletion analysis. Chao CW, Chan DC, Kuo A, Leder P. Mol Med. 1998 RT-PCR and ribonuclease protection analyses indicate that these transcripts are circular and are the major transcripts arising from this locus in adult brain and kidney. RT-PCR mouse adult brain and kidney circRIMS1 circRNA mus musculus RIMS1 27543790 Comprehensive characterization of tissue-specific circular RNAs in the human and mouse genomes. Xia S, Feng J, Lei L, Hu J, Xia L, Wang J, Xiang Y, Liu L, Zhong S, Han L, He C. Brief Bioinform. 2017 To validate the existence of TS circRNA, we perform RT-PCR experiment based on mouse tissues. TS circRNAs from five mouse tissues including the brain, heart, liver, lung and thymus were validated. These TS circRNAs are generated from exons of five protein-coding genes: RIMS1 in brain, PDE4DIP in heart, ADK in liver, LAMP3 in lung and SATB1 in thymus separately. qRT-PCR mouse brain circRNA Trerf1 circRNA mus musculus Trerf1 lead induced neuronal cell apoptosis 27604105 A novel regulatory network among LncRpa, CircRar1, MiR-671 and apoptotic genes promotes lead-induced neuronal cell apoptosis. Nan A, Chen L, Zhang N, Liu Z, Yang T, Wang Z, Yang C, Jiang Y. Arch Toxicol. 2017 circRNA Trerf1 level showed no change upon injury. qRT-PCR mouse cerebellum, pons, medulla oblongata, hippocampus and cerebral cortex. lead-treated N2a mouse nerve cells circPDE4DIP circRNA mus musculus PDE4DIP 27543790 Comprehensive characterization of tissue-specific circular RNAs in the human and mouse genomes. Xia S, Feng J, Lei L, Hu J, Xia L, Wang J, Xiang Y, Liu L, Zhong S, Han L, He C. Brief Bioinform. 2017 To validate the existence of TS circRNA, we perform RT-PCR experiment based on mouse tissues. TS circRNAs from five mouse tissues including the brain, heart, liver, lung and thymus were validated. These TS circRNAs are generated from exons of five protein-coding genes: RIMS1 in brain, PDE4DIP in heart, ADK in liver, LAMP3 in lung and SATB1 in thymus separately. qRT-PCR mouse heart circHipk3-1 circRNA mus musculus HIPK3 28082450 A landscape of circular RNA expression in the human heart. Tan WL, Lim BT, Anene-Nzelu CG, Ackers-Johnson M, Dashi A, See K, Tiang Z, Lee DP, Chua WW, Luu TD, Li PY, Richards AM, Foo RS. Cardiovasc Res. 2017 we definitively confirmed the back-spliced structure of 24/30 and 19/20 of human and mouse cardiac circRNA candidates by RT-PCR using junction-specific divergent primers and Sanger sequencing. qRT-PCR mouse hearts circMyh6-4 circRNA mus musculus Myh6 28082450 A landscape of circular RNA expression in the human heart. Tan WL, Lim BT, Anene-Nzelu CG, Ackers-Johnson M, Dashi A, See K, Tiang Z, Lee DP, Chua WW, Luu TD, Li PY, Richards AM, Foo RS. Cardiovasc Res. 2017 we definitively confirmed the back-spliced structure of 24/30 and 19/20 of human and mouse cardiac circRNA candidates by RT-PCR using junction-specific divergent primers and Sanger sequencing. qRT-PCR mouse hearts circMyocd-3 circRNA mus musculus Myocd 28082450 A landscape of circular RNA expression in the human heart. Tan WL, Lim BT, Anene-Nzelu CG, Ackers-Johnson M, Dashi A, See K, Tiang Z, Lee DP, Chua WW, Luu TD, Li PY, Richards AM, Foo RS. Cardiovasc Res. 2017 we definitively confirmed the back-spliced structure of 24/30 and 19/20 of human and mouse cardiac circRNA candidates by RT-PCR using junction-specific divergent primers and Sanger sequencing. qRT-PCR mouse hearts circNfix-3 circRNA mus musculus Nfix 28082450 A landscape of circular RNA expression in the human heart. Tan WL, Lim BT, Anene-Nzelu CG, Ackers-Johnson M, Dashi A, See K, Tiang Z, Lee DP, Chua WW, Luu TD, Li PY, Richards AM, Foo RS. Cardiovasc Res. 2017 we definitively confirmed the back-spliced structure of 24/30 and 19/20 of human and mouse cardiac circRNA candidates by RT-PCR using junction-specific divergent primers and Sanger sequencing. qRT-PCR mouse hearts circRyr2-3 circRNA mus musculus Ryr2 28082450 A landscape of circular RNA expression in the human heart. Tan WL, Lim BT, Anene-Nzelu CG, Ackers-Johnson M, Dashi A, See K, Tiang Z, Lee DP, Chua WW, Luu TD, Li PY, Richards AM, Foo RS. Cardiovasc Res. 2017 we definitively confirmed the back-spliced structure of 24/30 and 19/20 of human and mouse cardiac circRNA candidates by RT-PCR using junction-specific divergent primers and Sanger sequencing. qRT-PCR mouse hearts circSlc8a1-1 circRNA mus musculus Slc8a1 28082450 A landscape of circular RNA expression in the human heart. Tan WL, Lim BT, Anene-Nzelu CG, Ackers-Johnson M, Dashi A, See K, Tiang Z, Lee DP, Chua WW, Luu TD, Li PY, Richards AM, Foo RS. Cardiovasc Res. 2017 we definitively confirmed the back-spliced structure of 24/30 and 19/20 of human and mouse cardiac circRNA candidates by RT-PCR using junction-specific divergent primers and Sanger sequencing. qRT-PCR mouse hearts circTank-1 circRNA mus musculus Tank 28082450 A landscape of circular RNA expression in the human heart. Tan WL, Lim BT, Anene-Nzelu CG, Ackers-Johnson M, Dashi A, See K, Tiang Z, Lee DP, Chua WW, Luu TD, Li PY, Richards AM, Foo RS. Cardiovasc Res. 2017 we definitively confirmed the back-spliced structure of 24/30 and 19/20 of human and mouse cardiac circRNA candidates by RT-PCR using junction-specific divergent primers and Sanger sequencing. qRT-PCR mouse hearts circTcf20-2 circRNA mus musculus Tcf20 28082450 A landscape of circular RNA expression in the human heart. Tan WL, Lim BT, Anene-Nzelu CG, Ackers-Johnson M, Dashi A, See K, Tiang Z, Lee DP, Chua WW, Luu TD, Li PY, Richards AM, Foo RS. Cardiovasc Res. 2017 we definitively confirmed the back-spliced structure of 24/30 and 19/20 of human and mouse cardiac circRNA candidates by RT-PCR using junction-specific divergent primers and Sanger sequencing. qRT-PCR mouse hearts circTpm1-3 circRNA mus musculus Tpm1 28082450 A landscape of circular RNA expression in the human heart. Tan WL, Lim BT, Anene-Nzelu CG, Ackers-Johnson M, Dashi A, See K, Tiang Z, Lee DP, Chua WW, Luu TD, Li PY, Richards AM, Foo RS. Cardiovasc Res. 2017 we definitively confirmed the back-spliced structure of 24/30 and 19/20 of human and mouse cardiac circRNA candidates by RT-PCR using junction-specific divergent primers and Sanger sequencing. qRT-PCR mouse hearts circTrak1-2 circRNA mus musculus Trak1 28082450 A landscape of circular RNA expression in the human heart. Tan WL, Lim BT, Anene-Nzelu CG, Ackers-Johnson M, Dashi A, See K, Tiang Z, Lee DP, Chua WW, Luu TD, Li PY, Richards AM, Foo RS. Cardiovasc Res. 2017 we definitively confirmed the back-spliced structure of 24/30 and 19/20 of human and mouse cardiac circRNA candidates by RT-PCR using junction-specific divergent primers and Sanger sequencing. qRT-PCR mouse hearts circTtn-32 circRNA mus musculus Ttn 28082450 A landscape of circular RNA expression in the human heart. Tan WL, Lim BT, Anene-Nzelu CG, Ackers-Johnson M, Dashi A, See K, Tiang Z, Lee DP, Chua WW, Luu TD, Li PY, Richards AM, Foo RS. Cardiovasc Res. 2017 we definitively confirmed the back-spliced structure of 24/30 and 19/20 of human and mouse cardiac circRNA candidates by RT-PCR using junction-specific divergent primers and Sanger sequencing. qRT-PCR mouse hearts circTtn-63 circRNA mus musculus Ttn 28082450 A landscape of circular RNA expression in the human heart. Tan WL, Lim BT, Anene-Nzelu CG, Ackers-Johnson M, Dashi A, See K, Tiang Z, Lee DP, Chua WW, Luu TD, Li PY, Richards AM, Foo RS. Cardiovasc Res. 2017 we definitively confirmed the back-spliced structure of 24/30 and 19/20 of human and mouse cardiac circRNA candidates by RT-PCR using junction-specific divergent primers and Sanger sequencing. qRT-PCR mouse hearts circADK circRNA mus musculus ADK 27543790 Comprehensive characterization of tissue-specific circular RNAs in the human and mouse genomes. Xia S, Feng J, Lei L, Hu J, Xia L, Wang J, Xiang Y, Liu L, Zhong S, Han L, He C. Brief Bioinform. 2017 To validate the existence of TS circRNA, we perform RT-PCR experiment based on mouse tissues. TS circRNAs from five mouse tissues including the brain, heart, liver, lung and thymus were validated. These TS circRNAs are generated from exons of five protein-coding genes: RIMS1 in brain, PDE4DIP in heart, ADK in liver, LAMP3 in lung and SATB1 in thymus separately. qRT-PCR mouse liver circLAMP3 circRNA mus musculus LAMP3 27543790 Comprehensive characterization of tissue-specific circular RNAs in the human and mouse genomes. Xia S, Feng J, Lei L, Hu J, Xia L, Wang J, Xiang Y, Liu L, Zhong S, Han L, He C. Brief Bioinform. 2017 To validate the existence of TS circRNA, we perform RT-PCR experiment based on mouse tissues. TS circRNAs from five mouse tissues including the brain, heart, liver, lung and thymus were validated. These TS circRNAs are generated from exons of five protein-coding genes: RIMS1 in brain, PDE4DIP in heart, ADK in liver, LAMP3 in lung and SATB1 in thymus separately. qRT-PCR mouse lung Circ_Dcbld2 circRNA mus musculus Dcbld2 Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR mouse myoblasts Circ-Acvr2a circRNA mus musculus Acvr2a Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR mouse myoblasts Circ-Adamts6 circRNA mus musculus Adamts6 Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR mouse myoblasts Circ-Ankib1 circRNA mus musculus Ankib1 Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR mouse myoblasts Circ-Ash1l circRNA mus musculus Ash1l Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR mouse myoblasts Circ-Asph circRNA mus musculus Asph Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR mouse myoblasts Circ-Bach1 circRNA mus musculus Bach1 Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR mouse myoblasts Circ-Bnc2 circRNA mus musculus Bnc2 Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR mouse myoblasts Circ-Camsap1 circRNA mus musculus Camsap1 Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR mouse myoblasts Circ-Cdyl circRNA mus musculus Cdyl Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR mouse myoblasts Circ-Crkl circRNA mus musculus Crkl Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR mouse myoblasts Circ-Hipk3 circRNA mus musculus HIPK3 Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR mouse myoblasts Circ-Med13l circRNA mus musculus Med13l Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR mouse myoblasts Circ-Mef2a circRNA mus musculus Mef2a Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR mouse myoblasts Circ-Myl4 circRNA mus musculus Myl4 Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR mouse myoblasts Circ-Neb circRNA mus musculus Neb Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR mouse myoblasts Circ-Pms1 circRNA mus musculus Pms1 Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR mouse myoblasts Circ-Ptp4a2 circRNA mus musculus Ptp4a2 Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR mouse myoblasts Circ-Qk circRNA mus musculus Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR mouse myoblasts Circ-Rtn4 circRNA mus musculus Rtn4 Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR mouse myoblasts Circ-RTN4bis circRNA mus musculus Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR mouse myoblasts Circ-Runx1 circRNA mus musculus Runx1 Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR mouse myoblasts Circ-Sept9 circRNA mus musculus Sept9 Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR mouse myoblasts Circ-Slc8a1 circRNA mus musculus SLC8A1 Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR mouse myoblasts Circ-Specc1 circRNA mus musculus Specc1 Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR mouse myoblasts Circ-Tmeff1 circRNA mus musculus Tmeff1 Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR mouse myoblasts Circ-Ttn circRNA mus musculus Ttn Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR mouse myoblasts Circ-Zfhx3 circRNA mus musculus Zfhx3 Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR mouse myoblasts Circ-Zfp292 circRNA mus musculus Zfp292 Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR mouse myoblasts Circ-Zfp609 circRNA mus musculus Zfp609 Duchenne muscular dystrophy 28344082 Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I. Mol Cell. 2017 The normalized RNA quantities measured by qRT-PCR reflected the levels observed by RNA-seq and RT-PCR. RNA-seq, qRT-PCR mouse myoblasts Sry circular RNA circRNA mus musculus Sry 7684656 Circular transcripts of the testis-determining gene Sry in adult mouse testis. Capel B, Swain A, Nicolis S, Hacker A, Walter M, Koopman P, Goodfellow P, Lovell-Badge R. Cell. 1993 A non-translated circular Sry transcript is expressed in mouse RT-PCR mouse testis circSATB1 circRNA mus musculus SATB1 27543790 Comprehensive characterization of tissue-specific circular RNAs in the human and mouse genomes. Xia S, Feng J, Lei L, Hu J, Xia L, Wang J, Xiang Y, Liu L, Zhong S, Han L, He C. Brief Bioinform. 2017 To validate the existence of TS circRNA, we perform RT-PCR experiment based on mouse tissues. TS circRNAs from five mouse tissues including the brain, heart, liver, lung and thymus were validated. These TS circRNAs are generated from exons of five protein-coding genes: RIMS1 in brain, PDE4DIP in heart, ADK in liver, LAMP3 in lung and SATB1 in thymus separately. qRT-PCR mouse thymus circMyst4 circRNA mus musculus Myst4 25714049 Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity. You X, Vlatkovic I, Babic A, Will T, Epstein I, Tushev G, Akbalik G, Wang M, Glock C, Quedenau C, Wang X, Hou J, Liu H, Sun W, Sambandan S, Chen T, Schuman EM, Chen W. Nat Neurosci. 2015 increased over the course of development RNA-seq, qRT-PCR mouse tissues, including brain, heart, liver, lung and testis, hippocampi of adult mice and rat circDscam circRNA mus musculus Dscam 25714049 Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity. You X, Vlatkovic I, Babic A, Will T, Epstein I, Tushev G, Akbalik G, Wang M, Glock C, Quedenau C, Wang X, Hou J, Liu H, Sun W, Sambandan S, Chen T, Schuman EM, Chen W. Nat Neurosci. 2015 abundant particles present in the cell body and distributed particles observed throughout the dendritic arbor RNA-seq, qRT-PCR, FISH mouse tissues, including brain, heart, liver, lung and testis, hippocampi of adult mice and rat circElavl3 circRNA mus musculus Elavl3 25714049 Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity. You X, Vlatkovic I, Babic A, Will T, Epstein I, Tushev G, Akbalik G, Wang M, Glock C, Quedenau C, Wang X, Hou J, Liu H, Sun W, Sambandan S, Chen T, Schuman EM, Chen W. Nat Neurosci. 2015 abundant particles present in the cell body and distributed particles observed throughout the dendritic arbor RNA-seq, qRT-PCR, FISH mouse tissues, including brain, heart, liver, lung and testis, hippocampi of adult mice and rat circNbea circRNA mus musculus Nbea 25714049 Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity. You X, Vlatkovic I, Babic A, Will T, Epstein I, Tushev G, Akbalik G, Wang M, Glock C, Quedenau C, Wang X, Hou J, Liu H, Sun W, Sambandan S, Chen T, Schuman EM, Chen W. Nat Neurosci. 2015 abundant particles present in the cell body and distributed particles observed throughout the dendritic arbor RNA-seq, qRT-PCR, FISH mouse tissues, including brain, heart, liver, lung and testis, hippocampi of adult mice and rat circNlgn1 circRNA mus musculus Nlgn1 25714049 Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity. You X, Vlatkovic I, Babic A, Will T, Epstein I, Tushev G, Akbalik G, Wang M, Glock C, Quedenau C, Wang X, Hou J, Liu H, Sun W, Sambandan S, Chen T, Schuman EM, Chen W. Nat Neurosci. 2015 abundant particles present in the cell body and distributed particles observed throughout the dendritic arbor RNA-seq, qRT-PCR, FISH mouse tissues, including brain, heart, liver, lung and testis, hippocampi of adult mice and rat circRmst circRNA mus musculus Rmst 25714049 Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity. You X, Vlatkovic I, Babic A, Will T, Epstein I, Tushev G, Akbalik G, Wang M, Glock C, Quedenau C, Wang X, Hou J, Liu H, Sun W, Sambandan S, Chen T, Schuman EM, Chen W. Nat Neurosci. 2015 abundant particles present in the cell body and distributed particles observed throughout the dendritic arbor RNA-seq, qRT-PCR, FISH mouse tissues, including brain, heart, liver, lung and testis, hippocampi of adult mice and rat circEzh2 circRNA mus musculus Ezh2 25714049 Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity. You X, Vlatkovic I, Babic A, Will T, Epstein I, Tushev G, Akbalik G, Wang M, Glock C, Quedenau C, Wang X, Hou J, Liu H, Sun W, Sambandan S, Chen T, Schuman EM, Chen W. Nat Neurosci. 2015 detected in brain tissues RNA-seq, RT-PCR, qRT-PCR mouse tissues, including brain, heart, liver, lung and testis, hippocampi of adult mice and rat circUbe2k circRNA mus musculus Ube2k 25714049 Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity. You X, Vlatkovic I, Babic A, Will T, Epstein I, Tushev G, Akbalik G, Wang M, Glock C, Quedenau C, Wang X, Hou J, Liu H, Sun W, Sambandan S, Chen T, Schuman EM, Chen W. Nat Neurosci. 2015 detected in brain tissues RNA-seq, RT-PCR, qRT-PCR mouse tissues, including brain, heart, liver, lung and testis, hippocampi of adult mice and rat circUnc79 circRNA mus musculus Unc79 25714049 Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity. You X, Vlatkovic I, Babic A, Will T, Epstein I, Tushev G, Akbalik G, Wang M, Glock C, Quedenau C, Wang X, Hou J, Liu H, Sun W, Sambandan S, Chen T, Schuman EM, Chen W. Nat Neurosci. 2015 detected in brain tissues RNA-seq, RT-PCR, qRT-PCR mouse tissues, including brain, heart, liver, lung and testis, hippocampi of adult mice and rat circAagab circRNA mus musculus Aagab 25714049 Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity. You X, Vlatkovic I, Babic A, Will T, Epstein I, Tushev G, Akbalik G, Wang M, Glock C, Quedenau C, Wang X, Hou J, Liu H, Sun W, Sambandan S, Chen T, Schuman EM, Chen W. Nat Neurosci. 2015 increased over the course of development RNA-seq, RT-PCR, qRT-PCR mouse tissues, including brain, heart, liver, lung and testis, hippocampi of adult mice and rat circC2cd5 circRNA mus musculus C2cd5 25714049 Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity. You X, Vlatkovic I, Babic A, Will T, Epstein I, Tushev G, Akbalik G, Wang M, Glock C, Quedenau C, Wang X, Hou J, Liu H, Sun W, Sambandan S, Chen T, Schuman EM, Chen W. Nat Neurosci. 2015 increased over the course of development RNA-seq, RT-PCR, qRT-PCR mouse tissues, including brain, heart, liver, lung and testis, hippocampi of adult mice and rat circDigap1 circRNA mus musculus Digap1 25714049 Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity. You X, Vlatkovic I, Babic A, Will T, Epstein I, Tushev G, Akbalik G, Wang M, Glock C, Quedenau C, Wang X, Hou J, Liu H, Sun W, Sambandan S, Chen T, Schuman EM, Chen W. Nat Neurosci. 2015 increased over the course of development RNA-seq, RT-PCR, qRT-PCR mouse tissues, including brain, heart, liver, lung and testis, hippocampi of adult mice and rat circDtnb circRNA mus musculus Dtnb 25714049 Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity. You X, Vlatkovic I, Babic A, Will T, Epstein I, Tushev G, Akbalik G, Wang M, Glock C, Quedenau C, Wang X, Hou J, Liu H, Sun W, Sambandan S, Chen T, Schuman EM, Chen W. Nat Neurosci. 2015 increased over the course of development RNA-seq, RT-PCR, qRT-PCR mouse tissues, including brain, heart, liver, lung and testis, hippocampi of adult mice and rat circGigyf2 circRNA mus musculus Gigyf2 25714049 Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity. You X, Vlatkovic I, Babic A, Will T, Epstein I, Tushev G, Akbalik G, Wang M, Glock C, Quedenau C, Wang X, Hou J, Liu H, Sun W, Sambandan S, Chen T, Schuman EM, Chen W. Nat Neurosci. 2015 abundant particles present in the cell body and distributed particles observed throughout the dendritic arbor RNA-seq, RT-PCR, qRT-PCR, FISH mouse tissues, including brain, heart, liver, lung and testis, hippocampi of adult mice and rat circKlhl2 circRNA mus musculus Klhl2 25714049 Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity. You X, Vlatkovic I, Babic A, Will T, Epstein I, Tushev G, Akbalik G, Wang M, Glock C, Quedenau C, Wang X, Hou J, Liu H, Sun W, Sambandan S, Chen T, Schuman EM, Chen W. Nat Neurosci. 2015 exhibited strong upregulation during development RNA-seq, RT-PCR, qRT-PCR, FISH mouse tissues, including brain, heart, liver, lung and testis, hippocampi of adult mice and rat circHomer1 circRNA mus musculus Homer1 25714049 Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity. You X, Vlatkovic I, Babic A, Will T, Epstein I, Tushev G, Akbalik G, Wang M, Glock C, Quedenau C, Wang X, Hou J, Liu H, Sun W, Sambandan S, Chen T, Schuman EM, Chen W. Nat Neurosci. 2015 significantly upregulated in primary hippocampal neurons (P < 0.0005 for somata and P < 0.0208 for dendrites) and hippocampal slices RNA-seq, RT-PCR, qRT-PCR, FISH mouse tissues, including brain, heart, liver, lung and testis, hippocampi of adult mice and rat circRNA expression levels are regulated by neural plasticity ciRS-7 circRNA mus musculus Cdr1 Cdr1as myocardial infarction 26998750 The Circular RNA Cdr1as Promotes Myocardial Infarction by Mediating the Regulation of miR-7a on Its Target Genes Expression. Geng HH, Li R, Su YM, Xiao J, Pan M, Cai XX, Ji XP. PLoS One. 2016 Co-Expression of Cdr1as and miR-7a Was Detected during MI-Induced Injury or in Hypoxia-Treated Cardiomyocytes. upregulated in MI mice with increased cardiac infarct size, or cardiomyocytes under hypoxia treatment. qRT-PCR myocardial tissues from MI mice, primary cardiomyocytes, MCM (mouse cardiac myocytes) cells Overexpression of Cdr1as Aggravated MI Injuries with Upregulated PARP and SP1, which Could Be Rescued by the Co-Overexpression of miR-7a. Cdr1as overexpression in MCM cells promoted cell apoptosis, but was then reversed by miR-7a overexpression. gain of function Primary cardiomyocytes, mouse cardiac myocytes, MCM cells Male C57BL/6 mice of 8-week-old miR-7a/b circRNA-miRNA MCM well-identified circular RNAs (circRNAs), as a miR-7a/b sponge or inhibitor in brain tissues or islet cells PARP, SP1 circRNA_002581 circRNA mus musculus nonalcoholic steatohepatitis 27677588 CircRNA expression pattern and circRNA-miRNA-mRNA network in the pathogenesis of nonalcoholic steatohepatitis. Jin X, Feng CY, Xiang Z, Chen YP, Li YM. Oncotarget. 2016 differentially expressed between NASH and control groups. qRT-PCR NASH mice model and controls circRNA_007585 circRNA mus musculus nonalcoholic steatohepatitis 27677588 CircRNA expression pattern and circRNA-miRNA-mRNA network in the pathogenesis of nonalcoholic steatohepatitis. Jin X, Feng CY, Xiang Z, Chen YP, Li YM. Oncotarget. 2016 differentially expressed between NASH and control groups. qRT-PCR NASH mice model and controls circStk39 circRNA mus musculus Stk39 25921068 Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed. Rybak-Wolf A, Stottmeister C, Glažar P, Jens M, Pino N, Giusti S, Hanan M, Behm M, Bartok O, Ashwal-Fluss R, Herzog M, Schreyer L, Papavasileiou P, Ivanov A, Ohman M, Refojo D, Kadener S, Rajewsky N. Mol Cell. 2015 circStk39 was validated experimentally. qRT-PCR, northern blots P19 and SH-SY5Y cells, primary forebrain neurons from CD1 mouse embryos (E17.5¨CE18.5) circDym circRNA mus musculus Dym 25921068 Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed. Rybak-Wolf A, Stottmeister C, Glažar P, Jens M, Pino N, Giusti S, Hanan M, Behm M, Bartok O, Ashwal-Fluss R, Herzog M, Schreyer L, Papavasileiou P, Ivanov A, Ohman M, Refojo D, Kadener S, Rajewsky N. Mol Cell. 2015 We found several circRNAs enriched in specific brain regions¡ªindependent of their linear isoforms. Some circRNAs were highly enriched in the cerebellum: circRims2, circElf2, and circDym, while circPlxnd1 was enriched in the cortex. qRT-PCR, northern blots P19 and SH-SY5Y cells, primary forebrain neurons from CD1 mouse embryos (E17.5¨CE18.5) circPlxnd1 circRNA mus musculus Plxnd1 25921068 Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed. Rybak-Wolf A, Stottmeister C, Glažar P, Jens M, Pino N, Giusti S, Hanan M, Behm M, Bartok O, Ashwal-Fluss R, Herzog M, Schreyer L, Papavasileiou P, Ivanov A, Ohman M, Refojo D, Kadener S, Rajewsky N. Mol Cell. 2015 We found several circRNAs enriched in specific brain regions¡ªindependent of their linear isoforms. Some circRNAs were highly enriched in the cerebellum: circRims2, circElf2, and circDym, while circPlxnd1 was enriched in the cortex. qRT-PCR, northern blots P19 and SH-SY5Y cells, primary forebrain neurons from CD1 mouse embryos (E17.5¨CE18.5) circFxr2 circRNA mus musculus Fxr2 pigmentation 29377327 Comprehensive circRNA expression profile and construction of circRNA-associated ceRNA network in fur skin. Zhu Z, Li Y, Liu W, He J, Zhang L, Li H, Li P, Lv L. Exp Dermatol. 2018 highly expressed in BE compared with WE (P > .01) RNA-seq, qRT-PCR postnatal black fur skin (BP), postnatal of white fur skin (WP), embryo of white fur skin (WE), embryo of black fur skin (BE) circAtrnl1 circRNA mus musculus Atrnl1 pigmentation 29377327 Comprehensive circRNA expression profile and construction of circRNA-associated ceRNA network in fur skin. Zhu Z, Li Y, Liu W, He J, Zhang L, Li H, Li P, Lv L. Exp Dermatol. 2018 highly expressed in BP compared with WP (P > .01), and highly expressed in BE compared WE. RNA-seq, qRT-PCR postnatal black fur skin (BP), postnatal of white fur skin (WP), embryo of white fur skin (WE), embryo of black fur skin (BE) circKansl1l circRNA mus musculus Kansl1l pigmentation 29377327 Comprehensive circRNA expression profile and construction of circRNA-associated ceRNA network in fur skin. Zhu Z, Li Y, Liu W, He J, Zhang L, Li H, Li P, Lv L. Exp Dermatol. 2018 highly expressed in BP compared with WP (P > .01), and highly expressed in BE compared WE. RNA-seq, qRT-PCR postnatal black fur skin (BP), postnatal of white fur skin (WP), embryo of white fur skin (WE), embryo of black fur skin (BE) circHdac4 circRNA mus musculus Hdac4 pigmentation 29377327 Comprehensive circRNA expression profile and construction of circRNA-associated ceRNA network in fur skin. Zhu Z, Li Y, Liu W, He J, Zhang L, Li H, Li P, Lv L. Exp Dermatol. 2018 highly expressed in BP compared with WP (P > .05) RNA-seq, qRT-PCR postnatal black fur skin (BP), postnatal of white fur skin (WP), embryo of white fur skin (WE), embryo of black fur skin (BE) mmu_circRNA_004507 circRNA mus musculus osteoclastogenesis 26856880 Changing expression profiles of lncRNAs, mRNAs, circRNAs and miRNAs during osteoclastogenesis. Dou C, Cao Z, Yang B, Ding N, Hou T, Luo F, Kang F, Li J, Yang X, Jiang H, Xiang J, Quan H, Xu J, Dong S. Sci Rep. 2016 down regulated circRNAs among all comparison groups normalized to GAPDH. qRT-PCR RAW264.7 cells mmu_circRNA_006860 circRNA mus musculus osteoclastogenesis 26856880 Changing expression profiles of lncRNAs, mRNAs, circRNAs and miRNAs during osteoclastogenesis. Dou C, Cao Z, Yang B, Ding N, Hou T, Luo F, Kang F, Li J, Yang X, Jiang H, Xiang J, Quan H, Xu J, Dong S. Sci Rep. 2016 down regulated circRNAs among all comparison groups normalized to GAPDH. qRT-PCR RAW264.7 cells mmu_circRNA_007653 circRNA mus musculus osteoclastogenesis 26856880 Changing expression profiles of lncRNAs, mRNAs, circRNAs and miRNAs during osteoclastogenesis. Dou C, Cao Z, Yang B, Ding N, Hou T, Luo F, Kang F, Li J, Yang X, Jiang H, Xiang J, Quan H, Xu J, Dong S. Sci Rep. 2016 down regulated circRNAs among all comparison groups normalized to GAPDH. qRT-PCR RAW264.7 cells mmu_circRNA_009088 circRNA mus musculus osteoclastogenesis 26856880 Changing expression profiles of lncRNAs, mRNAs, circRNAs and miRNAs during osteoclastogenesis. Dou C, Cao Z, Yang B, Ding N, Hou T, Luo F, Kang F, Li J, Yang X, Jiang H, Xiang J, Quan H, Xu J, Dong S. Sci Rep. 2016 down regulated circRNAs among all comparison groups normalized to GAPDH. qRT-PCR RAW264.7 cells mmu_circRNA_017693 circRNA mus musculus osteoclastogenesis 26856880 Changing expression profiles of lncRNAs, mRNAs, circRNAs and miRNAs during osteoclastogenesis. Dou C, Cao Z, Yang B, Ding N, Hou T, Luo F, Kang F, Li J, Yang X, Jiang H, Xiang J, Quan H, Xu J, Dong S. Sci Rep. 2016 down regulated circRNAs among all comparison groups normalized to GAPDH. qRT-PCR RAW264.7 cells mmu_circRNA_003539 circRNA mus musculus osteoclastogenesis 26856880 Changing expression profiles of lncRNAs, mRNAs, circRNAs and miRNAs during osteoclastogenesis. Dou C, Cao Z, Yang B, Ding N, Hou T, Luo F, Kang F, Li J, Yang X, Jiang H, Xiang J, Quan H, Xu J, Dong S. Sci Rep. 2016 up regulated circRNAs among all comparison groups normalized to GAPDH. qRT-PCR RAW264.7 cells mmu_circRNA_005444 circRNA mus musculus osteoclastogenesis 26856880 Changing expression profiles of lncRNAs, mRNAs, circRNAs and miRNAs during osteoclastogenesis. Dou C, Cao Z, Yang B, Ding N, Hou T, Luo F, Kang F, Li J, Yang X, Jiang H, Xiang J, Quan H, Xu J, Dong S. Sci Rep. 2016 up regulated circRNAs among all comparison groups normalized to GAPDH. qRT-PCR RAW264.7 cells mmu_circRNA_007438 circRNA mus musculus osteoclastogenesis 26856880 Changing expression profiles of lncRNAs, mRNAs, circRNAs and miRNAs during osteoclastogenesis. Dou C, Cao Z, Yang B, Ding N, Hou T, Luo F, Kang F, Li J, Yang X, Jiang H, Xiang J, Quan H, Xu J, Dong S. Sci Rep. 2016 up regulated circRNAs among all comparison groups normalized to GAPDH. qRT-PCR RAW264.7 cells mmu_circRNA_007873 circRNA mus musculus osteoclastogenesis 26856880 Changing expression profiles of lncRNAs, mRNAs, circRNAs and miRNAs during osteoclastogenesis. Dou C, Cao Z, Yang B, Ding N, Hou T, Luo F, Kang F, Li J, Yang X, Jiang H, Xiang J, Quan H, Xu J, Dong S. Sci Rep. 2016 up regulated circRNAs among all comparison groups normalized to GAPDH. qRT-PCR RAW264.7 cells mmu_circRNA_008887 circRNA mus musculus osteoclastogenesis 26856880 Changing expression profiles of lncRNAs, mRNAs, circRNAs and miRNAs during osteoclastogenesis. Dou C, Cao Z, Yang B, Ding N, Hou T, Luo F, Kang F, Li J, Yang X, Jiang H, Xiang J, Quan H, Xu J, Dong S. Sci Rep. 2016 up regulated circRNAs among all comparison groups normalized to GAPDH. qRT-PCR RAW264.7 cells mcircRasGEF1B circRNA mus musculus 27362560 Inducible RasGEF1B circular RNA is a positive regulator of ICAM-1 in the TLR4/LPS pathway. Ng WL, Marinov GK, Liau ES, Lam YL, Lim YY, Ea CK. RNA Biol. 2016 Expression of mcircRasGEF1B was robustly induced by LPS and ODN CpG DNA, and to a lesser extent by poly I:C and Pam3CSK4. RNA-seq, qRT-PCR RAW264.7 cells, MEF mcircRasGEF1B regulates the expression of ICAM-1 in the LPS/TLR4 signaling pathway loss of function RAW264.7 mcircEtv6 circRNA mus musculus 27362560 Inducible RasGEF1B circular RNA is a positive regulator of ICAM-1 in the TLR4/LPS pathway. Ng WL, Marinov GK, Liau ES, Lam YL, Lim YY, Ea CK. RNA Biol. 2016 expressed in mouse macrophage RNA-seq, qRT-PCR RAW264.7 cells, MEF mcircLilrb3 circRNA mus musculus 27362560 Inducible RasGEF1B circular RNA is a positive regulator of ICAM-1 in the TLR4/LPS pathway. Ng WL, Marinov GK, Liau ES, Lam YL, Lim YY, Ea CK. RNA Biol. 2016 expressed in mouse macrophage RNA-seq, qRT-PCR RAW264.7 cells, MEF mcircPlcl2 circRNA mus musculus 27362560 Inducible RasGEF1B circular RNA is a positive regulator of ICAM-1 in the TLR4/LPS pathway. Ng WL, Marinov GK, Liau ES, Lam YL, Lim YY, Ea CK. RNA Biol. 2016 expressed in mouse macrophage RNA-seq, qRT-PCR RAW264.7 cells, MEF mcircUbe2d2 circRNA mus musculus 27362560 Inducible RasGEF1B circular RNA is a positive regulator of ICAM-1 in the TLR4/LPS pathway. Ng WL, Marinov GK, Liau ES, Lam YL, Lim YY, Ea CK. RNA Biol. 2016 expressed in mouse macrophage RNA-seq, qRT-PCR RAW264.7 cells, MEF mm10_circ_0011857 circRNA mus musculus Alzheimer¡¯s disease 28669840 Characterization of circRNA-Associated-ceRNA Networks in a Senescence-Accelerated Mouse Prone 8 Brain. Zhang S, Zhu D, Li H, Li H, Feng C, Zhang W. Mol Ther. 2017 Down-regulated in SAMP8 brain compared to SAMP1. RNA-seq, qRT-PCR SAMP8 brain, SAMP1 brain mm10_circ_0007422 circRNA mus musculus Alzheimer¡¯s disease 28669840 Characterization of circRNA-Associated-ceRNA Networks in a Senescence-Accelerated Mouse Prone 8 Brain. Zhang S, Zhu D, Li H, Li H, Feng C, Zhang W. Mol Ther. 2017 Up-regulated in SAMP8 brain compared to SAMP1. RNA-seq, qRT-PCR SAMP8 brain, SAMP1 brain mm10_circ_0013361 circRNA mus musculus Alzheimer¡¯s disease 28669840 Characterization of circRNA-Associated-ceRNA Networks in a Senescence-Accelerated Mouse Prone 8 Brain. Zhang S, Zhu D, Li H, Li H, Feng C, Zhang W. Mol Ther. 2017 Up-regulated in SAMP8 brain compared to SAMP1. RNA-seq, qRT-PCR SAMP8 brain, SAMP1 brain mus_cTtn1 circRNA mus musculus Ttn 27531932 RBM20 Regulates Circular RNA Production From the Titin Gene. Khan MA, Reckman YJ, Aufiero S, van den Hoogenhof MM, van der Made I, Beqqali A, Koolbergen DR, Rasmussen TB, van der Velden J, Creemers EE, Pinto YM. Circ Res. 2016 circRNAs produced from Ig repeats and PEVK domain RT-PCR wildtype, heterozygous Rbm20 KO circRNA expression is regulated by RNA-binding motif protein 20 mus_cTtn2 circRNA mus musculus Ttn 27531932 RBM20 Regulates Circular RNA Production From the Titin Gene. Khan MA, Reckman YJ, Aufiero S, van den Hoogenhof MM, van der Made I, Beqqali A, Koolbergen DR, Rasmussen TB, van der Velden J, Creemers EE, Pinto YM. Circ Res. 2016 circRNAs produced from Ig repeats and PEVK domain RT-PCR wildtype, heterozygous Rbm20 KO circRNA expression is regulated by RNA-binding motif protein 20 mus_cTtn3 circRNA mus musculus Ttn 27531932 RBM20 Regulates Circular RNA Production From the Titin Gene. Khan MA, Reckman YJ, Aufiero S, van den Hoogenhof MM, van der Made I, Beqqali A, Koolbergen DR, Rasmussen TB, van der Velden J, Creemers EE, Pinto YM. Circ Res. 2016 circRNAs produced from Ig repeats and PEVK domain RT-PCR wildtype, heterozygous Rbm20 KO circRNA expression is regulated by RNA-binding motif protein 20 mus_cTtn4 circRNA mus musculus Ttn 27531932 RBM20 Regulates Circular RNA Production From the Titin Gene. Khan MA, Reckman YJ, Aufiero S, van den Hoogenhof MM, van der Made I, Beqqali A, Koolbergen DR, Rasmussen TB, van der Velden J, Creemers EE, Pinto YM. Circ Res. 2016 circRNAs produced from Ig repeats and PEVK domain RT-PCR wildtype, heterozygous Rbm20 KO circRNA expression is regulated by RNA-binding motif protein 20 mus_cTtn5 circRNA mus musculus Ttn 27531932 RBM20 Regulates Circular RNA Production From the Titin Gene. Khan MA, Reckman YJ, Aufiero S, van den Hoogenhof MM, van der Made I, Beqqali A, Koolbergen DR, Rasmussen TB, van der Velden J, Creemers EE, Pinto YM. Circ Res. 2016 circRNAs produced from the Z-disk and N2A region RT-PCR wildtype, heterozygous Rbm20 KO and Rbm20 KO mice circRNA expression is regulated by RNA-binding motif protein 20 mus_cTtn6 circRNA mus musculus Ttn 27531932 RBM20 Regulates Circular RNA Production From the Titin Gene. Khan MA, Reckman YJ, Aufiero S, van den Hoogenhof MM, van der Made I, Beqqali A, Koolbergen DR, Rasmussen TB, van der Velden J, Creemers EE, Pinto YM. Circ Res. 2016 circRNAs produced from the Z-disk and N2A region RT-PCR wildtype, heterozygous Rbm20 KO and Rbm20 KO mice circRNA expression is regulated by RNA-binding motif protein 20 mmu_circRNA_19423 circRNA rattus norvegicus mmu_circRNA_19423 mouse orthology sequence induced acute respiratory distress syndrome 28864418 The expression profiles of circRNAs in lung tissues from rats with lipopolysaccharide-induced acute respiratory distress syndrome: A microarray study. Wan QQ, Wu D, Ye QF. Biochem Biophys Res Commun. 2017 Up-regulated in LPS group versus control group, which were consistent with the microarray results microarray, qRT-PCR lipopolysaccharide-induced acute respiratory distress syndrome model in rats rno-miR-708-5p, rno-miR-665, rno-miR-28-5p, rno-miR-485-5p, rno-miR-31a-3p circRNA-miRNA predicted mmu_circRNA_30664 circRNA rattus norvegicus mmu_circRNA_30664 mouse orthology sequence induced acute respiratory distress syndrome 28864418 The expression profiles of circRNAs in lung tissues from rats with lipopolysaccharide-induced acute respiratory distress syndrome: A microarray study. Wan QQ, Wu D, Ye QF. Biochem Biophys Res Commun. 2017 Up-regulated in LPS group versus control group, which were consistent with the microarray results microarray, qRT-PCR lipopolysaccharide-induced acute respiratory distress syndrome model in rats rno-miR-107-5p, rno-miR-214-3p, rno-miR-665, rno-miR-103-1-5p, rno-miR-3557-3p circRNA-miRNA predicted rno_circRNA_010489 circRNA rattus norvegicus induced acute respiratory distress syndrome 28864418 The expression profiles of circRNAs in lung tissues from rats with lipopolysaccharide-induced acute respiratory distress syndrome: A microarray study. Wan QQ, Wu D, Ye QF. Biochem Biophys Res Commun. 2017 Up-regulated in LPS group versus control group, which were consistent with the microarray results microarray, qRT-PCR lipopolysaccharide-induced acute respiratory distress syndrome model in rats rno-miR-466b-5p, rno-miR-328a-5p, rno-miR-665, rno-miR-361-3p, rno-miR-34c-5p circRNA-miRNA predicted rno_circRNA_005564 circRNA rattus norvegicus induced acute respiratory distress syndrome 28864418 The expression profiles of circRNAs in lung tissues from rats with lipopolysaccharide-induced acute respiratory distress syndrome: A microarray study. Wan QQ, Wu D, Ye QF. Biochem Biophys Res Commun. 2017 Down-regulated in LPS group versus control group, which were consistent with the microarray results microarray, qRT-PCR lipopolysaccharide-induced acute respiratory distress syndrome model in rats rno-miR-673-5p, rno-miR-219b, rno-miR-185-3p, rno-miR-5132-3p, rno-miR-146a-3p circRNA-miRNA predicted rno_circRNA_011426 circRNA rattus norvegicus induced acute respiratory distress syndrome 28864418 The expression profiles of circRNAs in lung tissues from rats with lipopolysaccharide-induced acute respiratory distress syndrome: A microarray study. Wan QQ, Wu D, Ye QF. Biochem Biophys Res Commun. 2017 Up-regulated in LPS group versus control group, which were consistent with the microarray results microarray, qRT-PCR lipopolysaccharide-induced acute respiratory distress syndrome model in rats rno-miR-874-3p, rno-miR-127-5p, rno-miR-101a-5p, rno-miR-148a-5p, rno-miR-3558-3p circRNA-miRNA predicted 2:27713879|27755789 circRNA rattus norvegicus osteogenesis 28919414 Changes in related circular RNAs following ERβ knockdown and the relationship to rBMSC osteogenesis. Li X, Peng B, Zhu X, Wang P, Xiong Y, Liu H, Sun K, Wang H, Ou L, Wu Z, Liu X, He H, Mo S, Peng X, Tian Y, Zhang R, Yang L. Biochem Biophys Res Commun. 2017 down-regulated in samples from the ERb knockdown groups compared to controls. qRT-PCR rat bone marrow-derived mesenchymal stem cells miR-328-5p circRNA-miRNA predicted miR-328-5p could be targeted by both 2:27713879j27755789 and 2:240822115j240867796 in the network, suggesting it might play a crucial role in osteogenesis. rno_circRNA_006016 circRNA rattus norvegicus Cardiovascular and Renal Diseases 28778982 Circular RNAs in rat models of cardiovascular and renal diseases. Cheng X, Joe B. Physiol Genomics. 2017 This differentially expressed circRNA shown in the microarray analysis was further validated by qRT-PCR and qRT-PCR amplified circRNA products were further confirmed using gel electrophoresis. microarray, qRT-PCR the Dahl salt-sensitive rat (S), the Dahl salt-resistant rat (R) rno-miR-297, rno-miR-466b-5p, rno-miR-423-5p, rno-miR-3573-5p and rno-miR-185-5p circRNA-miRNA predicted The top 5 predicted miRNA targets of rno_circRNA_006016 were rno-miR-297, rno-miR-466b-5p, rno-miR-423-5p, rno-miR-3573-5p and rno-miR-185-5p. 2:240822115|240867796 circRNA rattus norvegicus osteogenesis 28919414 Changes in related circular RNAs following ERβ knockdown and the relationship to rBMSC osteogenesis. Li X, Peng B, Zhu X, Wang P, Xiong Y, Liu H, Sun K, Wang H, Ou L, Wu Z, Liu X, He H, Mo S, Peng X, Tian Y, Zhang R, Yang L. Biochem Biophys Res Commun. 2017 up-regulated in samples from the ERb knockdown groups compared to controls. qRT-PCR miR-328-5p circRNA-miRNA predicted miR-328-5p could be targeted by both 2:27713879j27755789 and 2:240822115j240867796 in the network, suggesting it might play a crucial role in osteogenesis. circ-Phf21a circRNA rattus norvegicus Phf21a cardiovascular diseases 28676412 Identification of circular RNAs with host gene-independent expression in human model systems for cardiac differentiation and disease. Siede D, Rapti K, Gorska AA, Katus HA, Altmüller J, Boeckel JN, Meder B, Maack C, Völkers M, Müller OJ, Backs J, Dieterich C. J Mol Cell Cardiol. 2017 Argonaute 2 protein circRNA-protein cardiac myocytes from rat RIP Two circles (Slc8a1 and Phf21a) show an enrichment of BSJ reads (column 1-4, Figure 4D) in Argonaute 2 RIP experiments over linear spliced reads (column 5-8) and high-levels of Ago2 association (column 1,2) in comparison to the cytosolic fraction (column 3,4). circ-Slc8a1 circRNA rattus norvegicus Slc8a1 cardiovascular diseases 28676412 Identification of circular RNAs with host gene-independent expression in human model systems for cardiac differentiation and disease. Siede D, Rapti K, Gorska AA, Katus HA, Altmüller J, Boeckel JN, Meder B, Maack C, Völkers M, Müller OJ, Backs J, Dieterich C. J Mol Cell Cardiol. 2017 Argonaute 2 protein circRNA-protein cardiac myocytes from rat RIP Two circles (Slc8a1 and Phf21a) show an enrichment of BSJ reads (column 1-4, Figure 4D) in Argonaute 2 RIP experiments over linear spliced reads (column 5-8) and high-levels of Ago2 association (column 1,2) in comparison to the cytosolic fraction (column 3,4). chr1: 164931730¡¬164947123 circRNA rattus norvegicus acute lung injury 29188496 The differential expression of novel circular RNAs in an acute lung injury rat model caused by smoke inhalation. Ye Z, Liu X, Yang Y, Zhang X, Yu T, Li S, Feng Y, Luo G. J Physiol Biochem. 2018 The quantitative PCR combined with RNase digestion also supported the conclusion that the circRNA identified by our next-generation sequencing assay were truly in the circular loop form. RNA-seq, qRT-PCR bronchoalveolar lavage fluid and lung tissue of acute lung injury rat model chr19:49158646¡¬49159228 circRNA rattus norvegicus acute lung injury 29188496 The differential expression of novel circular RNAs in an acute lung injury rat model caused by smoke inhalation. Ye Z, Liu X, Yang Y, Zhang X, Yu T, Li S, Feng Y, Luo G. J Physiol Biochem. 2018 The quantitative PCR combined with RNase digestion also supported the conclusion that the circRNA identified by our next-generation sequencing assay were truly in the circular loop form. RNA-seq, qRT-PCR bronchoalveolar lavage fluid and lung tissue of acute lung injury rat model chr6: 72537858¡¬72538290 circRNA rattus norvegicus acute lung injury 29188496 The differential expression of novel circular RNAs in an acute lung injury rat model caused by smoke inhalation. Ye Z, Liu X, Yang Y, Zhang X, Yu T, Li S, Feng Y, Luo G. J Physiol Biochem. 2018 The quantitative PCR combined with RNase digestion also supported the conclusion that the circRNA identified by our next-generation sequencing assay were truly in the circular loop form. RNA-seq, qRT-PCR bronchoalveolar lavage fluid and lung tissue of acute lung injury rat model chr9:73798311¡¬73799430 circRNA rattus norvegicus acute lung injury 29188496 The differential expression of novel circular RNAs in an acute lung injury rat model caused by smoke inhalation. Ye Z, Liu X, Yang Y, Zhang X, Yu T, Li S, Feng Y, Luo G. J Physiol Biochem. 2018 The quantitative PCR combined with RNase digestion also supported the conclusion that the circRNA identified by our next-generation sequencing assay were truly in the circular loop form. RNA-seq, qRT-PCR bronchoalveolar lavage fluid and lung tissue of acute lung injury rat model 9:20596863|20599410 circRNA rattus norvegicus osteogenesis 28919414 Changes in related circular RNAs following ERβ knockdown and the relationship to rBMSC osteogenesis. Li X, Peng B, Zhu X, Wang P, Xiong Y, Liu H, Sun K, Wang H, Ou L, Wu Z, Liu X, He H, Mo S, Peng X, Tian Y, Zhang R, Yang L. Biochem Biophys Res Commun. 2017 up-regulated in samples from the ERb knockdown groups compared to controls. RNA-seq, qRT-PCR control and ERb-deficient rat bone marrow-derived mesenchymal stem cells rno_circRNA_007419 circRNA rattus norvegicus Chronic constriction injury of sciatic nerve 28761373 Chronic constriction injury of sciatic nerve changes circular RNA expression in rat spinal dorsal horn. Cao S, Deng W, Li Y, Qin B, Zhang L, Yu S, Xie P, Xiao Z, Yu T. J Pain Res. 2017 down-regulated in ipsilateral dorsal horn samples of CCI rat model microarray, qRT-PCR Ipsilateral dorsal horn samples of CCI rat model, controls rno_circRNA_007512 circRNA rattus norvegicus Chronic constriction injury of sciatic nerve 28761373 Chronic constriction injury of sciatic nerve changes circular RNA expression in rat spinal dorsal horn. Cao S, Deng W, Li Y, Qin B, Zhang L, Yu S, Xie P, Xiao Z, Yu T. J Pain Res. 2017 down-regulated in ipsilateral dorsal horn samples of CCI rat model microarray, qRT-PCR Ipsilateral dorsal horn samples of CCI rat model, controls rno_circRNA_010913 circRNA rattus norvegicus Chronic constriction injury of sciatic nerve 28761373 Chronic constriction injury of sciatic nerve changes circular RNA expression in rat spinal dorsal horn. Cao S, Deng W, Li Y, Qin B, Zhang L, Yu S, Xie P, Xiao Z, Yu T. J Pain Res. 2017 down-regulated in ipsilateral dorsal horn samples of CCI rat model microarray, qRT-PCR Ipsilateral dorsal horn samples of CCI rat model, controls rno_circRNA_011111 circRNA rattus norvegicus Chronic constriction injury of sciatic nerve 28761373 Chronic constriction injury of sciatic nerve changes circular RNA expression in rat spinal dorsal horn. Cao S, Deng W, Li Y, Qin B, Zhang L, Yu S, Xie P, Xiao Z, Yu T. J Pain Res. 2017 down-regulated in ipsilateral dorsal horn samples of CCI rat model microarray, qRT-PCR Ipsilateral dorsal horn samples of CCI rat model, controls rno_circRNA_008646 circRNA rattus norvegicus Chronic constriction injury of sciatic nerve 28761373 Chronic constriction injury of sciatic nerve changes circular RNA expression in rat spinal dorsal horn. Cao S, Deng W, Li Y, Qin B, Zhang L, Yu S, Xie P, Xiao Z, Yu T. J Pain Res. 2017 up-regulated in ipsilateral dorsal horn samples of CCI rat model microarray, qRT-PCR Ipsilateral dorsal horn samples of CCI rat model, controls rno_circRNA_008973 circRNA rattus norvegicus Chronic constriction injury of sciatic nerve 28761373 Chronic constriction injury of sciatic nerve changes circular RNA expression in rat spinal dorsal horn. Cao S, Deng W, Li Y, Qin B, Zhang L, Yu S, Xie P, Xiao Z, Yu T. J Pain Res. 2017 up-regulated in ipsilateral dorsal horn samples of CCI rat model microarray, qRT-PCR Ipsilateral dorsal horn samples of CCI rat model, controls rno_circRNA_013779 circRNA rattus norvegicus Chronic constriction injury of sciatic nerve 28761373 Chronic constriction injury of sciatic nerve changes circular RNA expression in rat spinal dorsal horn. Cao S, Deng W, Li Y, Qin B, Zhang L, Yu S, Xie P, Xiao Z, Yu T. J Pain Res. 2017 up-regulated in ipsilateral dorsal horn samples of CCI rat model microarray, qRT-PCR Ipsilateral dorsal horn samples of CCI rat model, controls rno_circRNA_35215 circRNA rattus norvegicus Chronic constriction injury of sciatic nerve 28761373 Chronic constriction injury of sciatic nerve changes circular RNA expression in rat spinal dorsal horn. Cao S, Deng W, Li Y, Qin B, Zhang L, Yu S, Xie P, Xiao Z, Yu T. J Pain Res. 2017 up-regulated in ipsilateral dorsal horn samples of CCI rat model microarray, qRT-PCR Ipsilateral dorsal horn samples of CCI rat model, controls circRNA_10008 circRNA rattus norvegicus mammary gland 26472973 Expression Patterns of Circular RNAs from Primary Kinase Transcripts in the Mammary Glands of Lactating Rats. Zhang C, Wu H, Wang Y, Zhao Y, Fang X, Chen C, Chen H. J Breast Cancer. 2015 RNase R resistance of all 11 novel backsplice events was apparent following RNase R treatment, whereas the abundance of linear RNAs was found to decrease. Moreover, oligo-dT priming for reverse transcription resulted in significantly lower levels of backspliced products relative to poly(A)-containing transcript levels, indicating that these species were not polyadenylated. The difference in the expression of the 11 circRNAs between the two time points was also confirmed by qPCR. RNA-seq, qRT-PCR Mammary Glands of Lactating Rats circRNA_127 circRNA rattus norvegicus mammary gland 26472973 Expression Patterns of Circular RNAs from Primary Kinase Transcripts in the Mammary Glands of Lactating Rats. Zhang C, Wu H, Wang Y, Zhao Y, Fang X, Chen C, Chen H. J Breast Cancer. 2015 RNase R resistance of all 11 novel backsplice events was apparent following RNase R treatment, whereas the abundance of linear RNAs was found to decrease. Moreover, oligo-dT priming for reverse transcription resulted in significantly lower levels of backspliced products relative to poly(A)-containing transcript levels, indicating that these species were not polyadenylated. The difference in the expression of the 11 circRNAs between the two time points was also confirmed by qPCR. RNA-seq, qRT-PCR Mammary Glands of Lactating Rats circRNA_15703 circRNA rattus norvegicus mammary gland 26472973 Expression Patterns of Circular RNAs from Primary Kinase Transcripts in the Mammary Glands of Lactating Rats. Zhang C, Wu H, Wang Y, Zhao Y, Fang X, Chen C, Chen H. J Breast Cancer. 2015 RNase R resistance of all 11 novel backsplice events was apparent following RNase R treatment, whereas the abundance of linear RNAs was found to decrease. Moreover, oligo-dT priming for reverse transcription resulted in significantly lower levels of backspliced products relative to poly(A)-containing transcript levels, indicating that these species were not polyadenylated. The difference in the expression of the 11 circRNAs between the two time points was also confirmed by qPCR. RNA-seq, qRT-PCR Mammary Glands of Lactating Rats circRNA_3385 circRNA rattus norvegicus mammary gland 26472973 Expression Patterns of Circular RNAs from Primary Kinase Transcripts in the Mammary Glands of Lactating Rats. Zhang C, Wu H, Wang Y, Zhao Y, Fang X, Chen C, Chen H. J Breast Cancer. 2015 RNase R resistance of all 11 novel backsplice events was apparent following RNase R treatment, whereas the abundance of linear RNAs was found to decrease. Moreover, oligo-dT priming for reverse transcription resulted in significantly lower levels of backspliced products relative to poly(A)-containing transcript levels, indicating that these species were not polyadenylated. The difference in the expression of the 11 circRNAs between the two time points was also confirmed by qPCR. RNA-seq, qRT-PCR Mammary Glands of Lactating Rats circRNA_36159 circRNA rattus norvegicus mammary gland 26472973 Expression Patterns of Circular RNAs from Primary Kinase Transcripts in the Mammary Glands of Lactating Rats. Zhang C, Wu H, Wang Y, Zhao Y, Fang X, Chen C, Chen H. J Breast Cancer. 2015 RNase R resistance of all 11 novel backsplice events was apparent following RNase R treatment, whereas the abundance of linear RNAs was found to decrease. Moreover, oligo-dT priming for reverse transcription resulted in significantly lower levels of backspliced products relative to poly(A)-containing transcript levels, indicating that these species were not polyadenylated. The difference in the expression of the 11 circRNAs between the two time points was also confirmed by qPCR. RNA-seq, qRT-PCR Mammary Glands of Lactating Rats circRNA_388 circRNA rattus norvegicus mammary gland 26472973 Expression Patterns of Circular RNAs from Primary Kinase Transcripts in the Mammary Glands of Lactating Rats. Zhang C, Wu H, Wang Y, Zhao Y, Fang X, Chen C, Chen H. J Breast Cancer. 2015 RNase R resistance of all 11 novel backsplice events was apparent following RNase R treatment, whereas the abundance of linear RNAs was found to decrease. Moreover, oligo-dT priming for reverse transcription resulted in significantly lower levels of backspliced products relative to poly(A)-containing transcript levels, indicating that these species were not polyadenylated. The difference in the expression of the 11 circRNAs between the two time points was also confirmed by qPCR. RNA-seq, qRT-PCR Mammary Glands of Lactating Rats circRNA_4815 circRNA rattus norvegicus mammary gland 26472973 Expression Patterns of Circular RNAs from Primary Kinase Transcripts in the Mammary Glands of Lactating Rats. Zhang C, Wu H, Wang Y, Zhao Y, Fang X, Chen C, Chen H. J Breast Cancer. 2015 RNase R resistance of all 11 novel backsplice events was apparent following RNase R treatment, whereas the abundance of linear RNAs was found to decrease. Moreover, oligo-dT priming for reverse transcription resulted in significantly lower levels of backspliced products relative to poly(A)-containing transcript levels, indicating that these species were not polyadenylated. The difference in the expression of the 11 circRNAs between the two time points was also confirmed by qPCR. RNA-seq, qRT-PCR Mammary Glands of Lactating Rats circRNA_537 circRNA rattus norvegicus mammary gland 26472973 Expression Patterns of Circular RNAs from Primary Kinase Transcripts in the Mammary Glands of Lactating Rats. Zhang C, Wu H, Wang Y, Zhao Y, Fang X, Chen C, Chen H. J Breast Cancer. 2015 RNase R resistance of all 11 novel backsplice events was apparent following RNase R treatment, whereas the abundance of linear RNAs was found to decrease. Moreover, oligo-dT priming for reverse transcription resulted in significantly lower levels of backspliced products relative to poly(A)-containing transcript levels, indicating that these species were not polyadenylated. The difference in the expression of the 11 circRNAs between the two time points was also confirmed by qPCR. RNA-seq, qRT-PCR Mammary Glands of Lactating Rats circRNA_555 circRNA rattus norvegicus mammary gland 26472973 Expression Patterns of Circular RNAs from Primary Kinase Transcripts in the Mammary Glands of Lactating Rats. Zhang C, Wu H, Wang Y, Zhao Y, Fang X, Chen C, Chen H. J Breast Cancer. 2015 RNase R resistance of all 11 novel backsplice events was apparent following RNase R treatment, whereas the abundance of linear RNAs was found to decrease. Moreover, oligo-dT priming for reverse transcription resulted in significantly lower levels of backspliced products relative to poly(A)-containing transcript levels, indicating that these species were not polyadenylated. The difference in the expression of the 11 circRNAs between the two time points was also confirmed by qPCR. RNA-seq, qRT-PCR Mammary Glands of Lactating Rats circRNA_659 circRNA rattus norvegicus mammary gland 26472973 Expression Patterns of Circular RNAs from Primary Kinase Transcripts in the Mammary Glands of Lactating Rats. Zhang C, Wu H, Wang Y, Zhao Y, Fang X, Chen C, Chen H. J Breast Cancer. 2015 RNase R resistance of all 11 novel backsplice events was apparent following RNase R treatment, whereas the abundance of linear RNAs was found to decrease. Moreover, oligo-dT priming for reverse transcription resulted in significantly lower levels of backspliced products relative to poly(A)-containing transcript levels, indicating that these species were not polyadenylated. The difference in the expression of the 11 circRNAs between the two time points was also confirmed by qPCR. RNA-seq, qRT-PCR Mammary Glands of Lactating Rats circRNA_7070 circRNA rattus norvegicus mammary gland 26472973 Expression Patterns of Circular RNAs from Primary Kinase Transcripts in the Mammary Glands of Lactating Rats. Zhang C, Wu H, Wang Y, Zhao Y, Fang X, Chen C, Chen H. J Breast Cancer. 2015 RNase R resistance of all 11 novel backsplice events was apparent following RNase R treatment, whereas the abundance of linear RNAs was found to decrease. Moreover, oligo-dT priming for reverse transcription resulted in significantly lower levels of backspliced products relative to poly(A)-containing transcript levels, indicating that these species were not polyadenylated. The difference in the expression of the 11 circRNAs between the two time points was also confirmed by qPCR. RNA-seq, qRT-PCR Mammary Glands of Lactating Rats circ137 circRNA rattus norvegicus liver regeneration 28086788 Comprehensive CircRNA expression profile and selection of key CircRNAs during priming phase of rat liver regeneration. Li L, Guo J, Chen Y, Chang C, Xu C. BMC Genomics. 2017 Down-regulated during priming phase of rat LR, which had accordance with the high-throughput sequencing result. RNA-seq, qRT-PCR priming phase of rat liver regeneration circ2270 circRNA rattus norvegicus liver regeneration 28086788 Comprehensive CircRNA expression profile and selection of key CircRNAs during priming phase of rat liver regeneration. Li L, Guo J, Chen Y, Chang C, Xu C. BMC Genomics. 2017 Down-regulated during priming phase of rat LR, which had accordance with the high-throughput sequencing result. RNA-seq, qRT-PCR priming phase of rat liver regeneration circ1366 circRNA rattus norvegicus TNFRSF21 liver regeneration 28086788 Comprehensive CircRNA expression profile and selection of key CircRNAs during priming phase of rat liver regeneration. Li L, Guo J, Chen Y, Chang C, Xu C. BMC Genomics. 2017 Up-regulated during priming phase of rat LR, which had accordance with the high-throughput sequencing result. RNA-seq, qRT-PCR priming phase of rat liver regeneration circ15 circRNA rattus norvegicus GOT1 liver regeneration 28086788 Comprehensive CircRNA expression profile and selection of key CircRNAs during priming phase of rat liver regeneration. Li L, Guo J, Chen Y, Chang C, Xu C. BMC Genomics. 2017 Up-regulated during priming phase of rat LR, which had accordance with the high-throughput sequencing result. RNA-seq, qRT-PCR priming phase of rat liver regeneration circ2077 circRNA rattus norvegicus FN1 liver regeneration 28086788 Comprehensive CircRNA expression profile and selection of key CircRNAs during priming phase of rat liver regeneration. Li L, Guo J, Chen Y, Chang C, Xu C. BMC Genomics. 2017 Up-regulated during priming phase of rat LR, which had accordance with the high-throughput sequencing result. RNA-seq, qRT-PCR priming phase of rat liver regeneration circ432 circRNA rattus norvegicus MAPK14 liver regeneration 28086788 Comprehensive CircRNA expression profile and selection of key CircRNAs during priming phase of rat liver regeneration. Li L, Guo J, Chen Y, Chang C, Xu C. BMC Genomics. 2017 Up-regulated during priming phase of rat LR, which had accordance with the high-throughput sequencing result. RNA-seq, qRT-PCR priming phase of rat liver regeneration 10:71546978|71557193 circRNA rattus norvegicus osteogenesis 28919414 Changes in related circular RNAs following ERβ knockdown and the relationship to rBMSC osteogenesis. Li X, Peng B, Zhu X, Wang P, Xiong Y, Liu H, Sun K, Wang H, Ou L, Wu Z, Liu X, He H, Mo S, Peng X, Tian Y, Zhang R, Yang L. Biochem Biophys Res Commun. 2017 down-regulated in samples from the ERb knockdown groups compared to controls. qRT-PCR rat bone marrow-derived mesenchymal stem cells 15:103872241|103886205 circRNA rattus norvegicus osteogenesis 28919414 Changes in related circular RNAs following ERβ knockdown and the relationship to rBMSC osteogenesis. Li X, Peng B, Zhu X, Wang P, Xiong Y, Liu H, Sun K, Wang H, Ou L, Wu Z, Liu X, He H, Mo S, Peng X, Tian Y, Zhang R, Yang L. Biochem Biophys Res Commun. 2017 down-regulated in samples from the ERb knockdown groups compared to controls. qRT-PCR rat bone marrow-derived mesenchymal stem cells 16:23555919|23600154 circRNA rattus norvegicus osteogenesis 28919414 Changes in related circular RNAs following ERβ knockdown and the relationship to rBMSC osteogenesis. Li X, Peng B, Zhu X, Wang P, Xiong Y, Liu H, Sun K, Wang H, Ou L, Wu Z, Liu X, He H, Mo S, Peng X, Tian Y, Zhang R, Yang L. Biochem Biophys Res Commun. 2017 down-regulated in samples from the ERb knockdown groups compared to controls. qRT-PCR rat bone marrow-derived mesenchymal stem cells 2:23399715|23410608 circRNA rattus norvegicus osteogenesis 28919414 Changes in related circular RNAs following ERβ knockdown and the relationship to rBMSC osteogenesis. Li X, Peng B, Zhu X, Wang P, Xiong Y, Liu H, Sun K, Wang H, Ou L, Wu Z, Liu X, He H, Mo S, Peng X, Tian Y, Zhang R, Yang L. Biochem Biophys Res Commun. 2017 down-regulated in samples from the ERb knockdown groups compared to controls. qRT-PCR rat bone marrow-derived mesenchymal stem cells circSgms2_2¨C3 circRNA rattus norvegicus Sgms2 KU840805 TATCCAACGGGCTACGAAAGGGTGCCAAGAAATACCCGGACTACATCCAGATTTCCATGCCCAATGACTCCAGGAACAAGCTTCCCCTAGAGTGGTGGAAAACAGGCATTGCCTTTGTGTACGCTCTCTTCAACCTTATCCTGACAACAGTCATGATCACCGTTGTGCACGAGAGGGTCCCTCCCAAGGAACTCAGCCCTCCACTCCCAGACAAGTTTTTTGATTACGTCGACCGGGTCAAATGGGCATTTTCTGTATCAGAAATAAATGGGATGGTATTAGTTGGGCTATGGCTCACCCAGTGGCTCTTTCTGAGATACAAAAGGGACAATACCATCCTCTGTGGGAAGGAGAACCAGCTTCCTTGTGGTGACTACACAGCAGACCAGAAGGCCACCGTCTACGATTCATATCAGCACACACAGTCTATCCTAAGAGTCCATGTTGATCTTGGAAGTAGAGAGGTTTAAAAGAAGTTCCCACAGAAACCAAGAGCCTTACCATCTCCTTTAGCTCCGAAGGCTGGCGGACAATGGATATCATAGAGACAGCAAAACTTGAAGGTCATTTGGAAAGTCAAACCAACAACTCTACCAACACTTACACAAGCCCCACTGAAGCTGTAGAAGAGGAGGACAAAAATGGCAAGGGTAAACCCAAGACCT sphingomyelin synthase activity 29294205 Developmental stage-specific expression of genes for sphingomyelin synthase in rat brain. Filippenkov IB, Kolomin TA, Limborska SA, Dergunova LV. Cell Tissue Res. 2018 Using RT¨CPCR and Sanger sequencing of rat brain cDNA samples, we were able to detect two circRNAs: circSgms2_2 (665 nt) and circSgms2_2¨C3 (783 nt). The analysis of the revealed circRNAs circSgms2_2 and circSgms2_2¨C3 in the brain of rats was conducted by real-time PCR. RT¨CPCR, sanger sequencing, qRT-PCR rat brain circSgms2_2 circRNA rattus norvegicus Sgms2 KU840804 TATCCAACGGGCTACGAAAGGGTGCCAAGAAATACCCGGACTACATCCAGATTTCCATGCCCAATGACTCCAGGAACAAGCTTCCCCTAGAGTGGTGGAAAACAGGCATTGCCTTTGTGTACGCTCTCTTCAACCTTATCCTGACAACAGTCATGATCACCGTTGTGCACGAGAGGGTCCCTCCCAAGGAACTCAGCCCTCCACTCCCAGACAAGTTTTTTGATTACGTCGACCGGGTCAAATGGGCATTTTCTGTATCAGAAATAAATGGGATGGTATTAGTTGGGCTATGGCTCACCCAGTGGCTCTTTCTGAGATACAAGTCAATAGTGGGACGCAGATTCTTCTTTATCATGGGAACTTTATACCTGTATCGCTGTATAACTATGTACGTCACTACGTTACCTGTGCCCGGAATGCACTTCCAGTGTGCTCCAAAGAAGGGACAATACCATCCTCTGTGGGAAGGAGAACCAGCTTCCTTGTGGTGACTACACAGCAGACCAGAAGGCCACCGTCTACGATTCATATCAGCACACACAGTCTATCCTAAGAGTCCATGTTGATCTTGGAAGTAGAGAGGTTTAAAAGAAGTTCCCACAGAAACCAAGAGCCTTACCATCTCCTTTAGCTCCGAAGGCTGGCGGACAATGGATATCATAGAGACAGCAAAACTTGAAGGTCATTTGGAAAGTCAAACCAACAACTCTACCAACACTTACACAAGCCCCACTGAAGCTGTAGAAGAGGAGGACAAAAATGGCAAGGGTAAACCCAAGACCT sphingomyelin synthase activity 29294205 Developmental stage-specific expression of genes for sphingomyelin synthase in rat brain. Filippenkov IB, Kolomin TA, Limborska SA, Dergunova LV. Cell Tissue Res. 2018 Using RT¨CPCR and Sanger sequencing of rat brain cDNA samples, we were able to detect two circRNAs: circSgms2_2 (665 nt) and circSgms2_2¨C3 (783 nt). The analysis of the revealed circRNAs circSgms2_2 and circSgms2_2¨C3 in the brain of rats was conducted by real-time PCR. RT¨CPCR, sanger sequencing, qRT-PCR rat brain circCyp2c24 circRNA rattus norvegicus Cyp2c24 TTCTCAAAAATTTATGGCCCTGTGTTCACTCTGTACTTTGGTCCGAAGCCTACTGTGGTGGTACATGGATATGAAGCAGTAAAGGAAGCCCTGGATGATCTTGGAGAGGAGTTTTCTGGGAGGGGTAGTTTCCCAATTGTTGAAAGAATGAATAATGGCCTTGGGGTCATTTTCAGCAATGGAACAAAATGGAAGGAGCTTCGGCATTTCTCACTTATGACCTTGAGAAATTTTGGGATGGGGAAGAGGAGCATCGAGGATCGCATTCAAGAGGAAGCCTCCTGTCTTGTGGAAGAGCTAAGAAAAACAAATGGCTCACTCTGTGATCCCACATTCATCCTGAGCTGTGCTCCCTCCAACGTGATCTGCTCAGTTGTTTTCCATAATCGTTTTGATTATAAAGATGAGAATTTCCTTAACTTGATGGAGAAACTCAATGAAAACTTTAAAATCTTGAACTCCCCATGGATGCAG 8692851 Circular RNAs from transcripts of the rat cytochrome P450 2C24 gene: correlation with exon skipping. Zaphiropoulos PG. Proc Natl Acad Sci U S A. 1996 Expressed in liver and kidney tissue RT-PCR rat liver and kidney tissue rno_circ_0005854 circRNA rattus norvegicus Neuropathic pain 28420964 Identification of the Spinal Expression Profile of Non-coding RNAs Involved in Neuropathic Pain Following Spared Nerve Injury by Sequence Analysis. Zhou J, Xiong Q, Chen H, Yang C, Fan Y. Front Mol Neurosci. 2017 Down-regulated in the SNI group compared with the CON group at 14 days after spared nerve injury. RNA-seq, qRT-PCR spinal cord following spared nerve injury-induced NP, controls rno_circ_0004058 circRNA rattus norvegicus Neuropathic pain 28420964 Identification of the Spinal Expression Profile of Non-coding RNAs Involved in Neuropathic Pain Following Spared Nerve Injury by Sequence Analysis. Zhou J, Xiong Q, Chen H, Yang C, Fan Y. Front Mol Neurosci. 2017 Up-regulated in the SNI group compared with the CON group at 14 days after spared nerve injury. RNA-seq, qRT-PCR spinal cord following spared nerve injury-induced NP, controls rno_circRNA_001167 circRNA rattus norvegicus Traumatic Brain Injury 29357736 Circular RNA Expression Profiles Alter Significantly After Traumatic Brain Injury in Rats. Xie B, Wang Y, Lin Y, Zhao CC, Mao Q, Feng JF, Cao J, Gao GY, Jiang J. J Neurotrauma. 2018 downregulated significantly after TBI microarray, qRT-PCR TBI rat model rno_circRNA_001168 circRNA rattus norvegicus Traumatic Brain Injury 29357736 Circular RNA Expression Profiles Alter Significantly After Traumatic Brain Injury in Rats. Xie B, Wang Y, Lin Y, Zhao CC, Mao Q, Feng JF, Cao J, Gao GY, Jiang J. J Neurotrauma. 2018 downregulated significantly after TBI microarray, qRT-PCR TBI rat model rno_circRNA_006508 circRNA rattus norvegicus Traumatic Brain Injury 29357736 Circular RNA Expression Profiles Alter Significantly After Traumatic Brain Injury in Rats. Xie B, Wang Y, Lin Y, Zhao CC, Mao Q, Feng JF, Cao J, Gao GY, Jiang J. J Neurotrauma. 2018 upregulated significantly after TBI microarray, qRT-PCR TBI rat model rno_circRNA_010705 circRNA rattus norvegicus Traumatic Brain Injury 29357736 Circular RNA Expression Profiles Alter Significantly After Traumatic Brain Injury in Rats. Xie B, Wang Y, Lin Y, Zhao CC, Mao Q, Feng JF, Cao J, Gao GY, Jiang J. J Neurotrauma. 2018 upregulated significantly after TBI microarray, qRT-PCR TBI rat model chr5:90817794|90827570 circRNA rattus norvegicus cardiovascular diseases 29521313 Identification of differentially expressed circular RNAs during TGF-beta1-induced endothelial-to-mesenchymal transition in rat coronary artery endothelial cells. Huang X, Chen Y, Xiao J, Huang Z, He L, Xu D, Peng J. Anatol J Cardiol. 2018 dramatically increased in TGF-¦Â1-treated rat CAEC compared with normal control group (p < 0.001). These results showed the same trend of high-throughput sequencing. RNA-seq, qRT-PCR TGF-¦Â1-treated rat coronary artery endothelial cells, controls chr6:22033342|22038870 circRNA rattus norvegicus cardiovascular diseases 29521313 Identification of differentially expressed circular RNAs during TGF-beta1-induced endothelial-to-mesenchymal transition in rat coronary artery endothelial cells. Huang X, Chen Y, Xiao J, Huang Z, He L, Xu D, Peng J. Anatol J Cardiol. 2018 dramatically increased in TGF-¦Â1-treated rat CAEC compared with normal control group (p < 0.001). These results showed the same trend of high-throughput sequencing. RNA-seq, qRT-PCR TGF-¦Â1-treated rat coronary artery endothelial cells, controls chr8:71336875|71337745 circRNA rattus norvegicus cardiovascular diseases 29521313 Identification of differentially expressed circular RNAs during TGF-beta1-induced endothelial-to-mesenchymal transition in rat coronary artery endothelial cells. Huang X, Chen Y, Xiao J, Huang Z, He L, Xu D, Peng J. Anatol J Cardiol. 2018 dramatically increased in TGF-¦Â1-treated rat CAEC compared with normal control group (p < 0.001). These results showed the same trend of high-throughput sequencing. RNA-seq, qRT-PCR TGF-¦Â1-treated rat coronary artery endothelial cells, controls rno_circRNA_000714 circRNA rattus norvegicus Cardiovascular and Renal Diseases 28778982 Circular RNAs in rat models of cardiovascular and renal diseases. Cheng X, Joe B. Physiol Genomics. 2017 This differentially expressed circRNA shown in the microarray analysis was further validated by qRT-PCR and qRT-PCR amplified circRNA products were further confirmed using gel electrophoresis. microarray, qRT-PCR the 25 spontaneously hypertensive rat (SHR) and the Wistar Kyoto rat (WKY). rno_circRNA_004637 circRNA rattus norvegicus Cardiovascular and Renal Diseases 28778982 Circular RNAs in rat models of cardiovascular and renal diseases. Cheng X, Joe B. Physiol Genomics. 2017 This differentially expressed circRNA shown in the microarray analysis was further validated by qRT-PCR and qRT-PCR amplified circRNA products were further confirmed using gel electrophoresis. microarray, qRT-PCR the 25 spontaneously hypertensive rat (SHR) and the Wistar Kyoto rat (WKY). rno_circRNA_006923 circRNA rattus norvegicus Cardiovascular and Renal Diseases 28778982 Circular RNAs in rat models of cardiovascular and renal diseases. Cheng X, Joe B. Physiol Genomics. 2017 This differentially expressed circRNA shown in the microarray analysis was further validated by qRT-PCR and qRT-PCR amplified circRNA products were further confirmed using gel electrophoresis. microarray, qRT-PCR the 25 spontaneously hypertensive rat (SHR) and the Wistar Kyoto rat (WKY). rno_circRNA_010885 circRNA rattus norvegicus Cardiovascular and Renal Diseases 28778982 Circular RNAs in rat models of cardiovascular and renal diseases. Cheng X, Joe B. Physiol Genomics. 2017 This differentially expressed circRNA shown in the microarray analysis was further validated by qRT-PCR and qRT-PCR amplified circRNA products were further confirmed using gel electrophoresis. microarray, qRT-PCR the 25 spontaneously hypertensive rat (SHR) and the Wistar Kyoto rat (WKY). rno_circRNA_010886 circRNA rattus norvegicus Cardiovascular and Renal Diseases 28778982 Circular RNAs in rat models of cardiovascular and renal diseases. Cheng X, Joe B. Physiol Genomics. 2017 This differentially expressed circRNA shown in the microarray analysis was further validated by qRT-PCR and qRT-PCR amplified circRNA products were further confirmed using gel electrophoresis. microarray, qRT-PCR the 25 spontaneously hypertensive rat (SHR) and the Wistar Kyoto rat (WKY). rno_circRNA_013859 circRNA rattus norvegicus Cardiovascular and Renal Diseases 28778982 Circular RNAs in rat models of cardiovascular and renal diseases. Cheng X, Joe B. Physiol Genomics. 2017 This differentially expressed circRNA shown in the microarray analysis was further validated by qRT-PCR and qRT-PCR amplified circRNA products were further confirmed using gel electrophoresis. microarray, qRT-PCR the 25 spontaneously hypertensive rat (SHR) and the Wistar Kyoto rat (WKY). rno_circRNA_004804 circRNA rattus norvegicus Cardiovascular and Renal Diseases 28778982 Circular RNAs in rat models of cardiovascular and renal diseases. Cheng X, Joe B. Physiol Genomics. 2017 This differentially expressed circRNA shown in the microarray analysis was further validated by qRT-PCR and qRT-PCR amplified circRNA products were further confirmed using gel electrophoresis. microarray, qRT-PCR the Dahl salt-sensitive rat (S), the Dahl salt-resistant rat (R) rno_circRNA_004811 circRNA rattus norvegicus Cardiovascular and Renal Diseases 28778982 Circular RNAs in rat models of cardiovascular and renal diseases. Cheng X, Joe B. Physiol Genomics. 2017 This differentially expressed circRNA shown in the microarray analysis was further validated by qRT-PCR and qRT-PCR amplified circRNA products were further confirmed using gel electrophoresis. microarray, qRT-PCR the Dahl salt-sensitive rat (S), the Dahl salt-resistant rat (R) rno_circRNA_014746 circRNA rattus norvegicus Cardiovascular and Renal Diseases 28778982 Circular RNAs in rat models of cardiovascular and renal diseases. Cheng X, Joe B. Physiol Genomics. 2017 This differentially expressed circRNA shown in the microarray analysis was further validated by qRT-PCR and qRT-PCR amplified circRNA products were further confirmed using gel electrophoresis. microarray, qRT-PCR the Dahl salt-sensitive rat (S), the Dahl salt-resistant rat (R) 18:75429814|75430443 circRNA rattus norvegicus osteogenesis 28919414 Changes in related circular RNAs following ERβ knockdown and the relationship to rBMSC osteogenesis. Li X, Peng B, Zhu X, Wang P, Xiong Y, Liu H, Sun K, Wang H, Ou L, Wu Z, Liu X, He H, Mo S, Peng X, Tian Y, Zhang R, Yang L. Biochem Biophys Res Commun. 2017 up-regulated in samples from the ERb knockdown groups compared to controls. qRT-PCR chi_circ_0008219 circRNA capra hircus ovarian follicular development 29107014 Circular RNA profiling reveals chi_circ_0008219 function as microRNA sponges in pre-ovulatory ovarian follicles of goats (Capra hircus). Tao H, Xiong Q, Zhang F, Zhang N, Liu Y, Suo X, Li X, Yang Q, Chen M. Genomics. 2017 Upregulated in the pre-ovulatory follicles of Macheng goat and Boer goat. qRT-PCR, RNA-seq pre-ovulatory follicles of Macheng goat and Boer goat chi-miR-34c-5p,chi-miR-483,chi-miR-1468-3p circRNA-miRNA CHO cells luciferase reporter assay MiRbase software predicted that chi_circ_0008219 contained a putative miRNA binding site. To identify the miRNAs that bind to chi_circ_0008219, a 1788 bp region of chi_circ_0008219 was cloned into the pmirGLO vector. The miRNA mimic of chi-miR-34c-5p, chimiR-483 and chi-miR-1468-3p was co-transfected with the 8219-pmirGLO luciferase reporters into Chinese hamster ovary cell (CHO). Compared with the negative control (NC) miRNA mimic, chi-miR-34c-5p and chi-miR-1468-3p were able to significantly reduce the luciferase reporter activities (P < 0.01) and chi-miR-483 could significantly reduce the luciferase reporter activities (P < 0.05). Three miRNA mutants (chi-miR-34c-5p mut, chi-miR-483 mut and chi-miR-1468-3p mut) were transfected into CHO cells. We discovered that these mutations completely abolished the suppression of luciferase activity compare with the wild-type vector. These results suggest that chi_circ_0008219 may function as a sponge to these miRNAs. chi_circ_0003472 circRNA capra hircus ovarian follicular development 29107014 Circular RNA profiling reveals chi_circ_0008219 function as microRNA sponges in pre-ovulatory ovarian follicles of goats (Capra hircus). Tao H, Xiong Q, Zhang F, Zhang N, Liu Y, Suo X, Li X, Yang Q, Chen M. Genomics. 2017 Downregulated in the pre-ovulatory follicles of Macheng goat and Boer goat. qRT-PCR, RNA-seq pre-ovulatory follicles of Macheng goat and Boer goat chi_circ_0003645 circRNA capra hircus ovarian follicular development 29107014 Circular RNA profiling reveals chi_circ_0008219 function as microRNA sponges in pre-ovulatory ovarian follicles of goats (Capra hircus). Tao H, Xiong Q, Zhang F, Zhang N, Liu Y, Suo X, Li X, Yang Q, Chen M. Genomics. 2017 Downregulated in the pre-ovulatory follicles of Macheng goat and Boer goat. qRT-PCR, RNA-seq pre-ovulatory follicles of Macheng goat and Boer goat chi_circ_0003652 circRNA capra hircus ovarian follicular development 29107014 Circular RNA profiling reveals chi_circ_0008219 function as microRNA sponges in pre-ovulatory ovarian follicles of goats (Capra hircus). Tao H, Xiong Q, Zhang F, Zhang N, Liu Y, Suo X, Li X, Yang Q, Chen M. Genomics. 2017 Downregulated in the pre-ovulatory follicles of Macheng goat and Boer goat. qRT-PCR, RNA-seq pre-ovulatory follicles of Macheng goat and Boer goat chi_circ_0011200 circRNA capra hircus ovarian follicular development 29107014 Circular RNA profiling reveals chi_circ_0008219 function as microRNA sponges in pre-ovulatory ovarian follicles of goats (Capra hircus). Tao H, Xiong Q, Zhang F, Zhang N, Liu Y, Suo X, Li X, Yang Q, Chen M. Genomics. 2017 Downregulated in the pre-ovulatory follicles of Macheng goat and Boer goat. qRT-PCR, RNA-seq pre-ovulatory follicles of Macheng goat and Boer goat chi_circ_0003965 circRNA capra hircus ovarian follicular development 29107014 Circular RNA profiling reveals chi_circ_0008219 function as microRNA sponges in pre-ovulatory ovarian follicles of goats (Capra hircus). Tao H, Xiong Q, Zhang F, Zhang N, Liu Y, Suo X, Li X, Yang Q, Chen M. Genomics. 2017 Upregulated in the pre-ovulatory follicles of Macheng goat and Boer goat. qRT-PCR, RNA-seq pre-ovulatory follicles of Macheng goat and Boer goat chi_circ_0004436 circRNA capra hircus ovarian follicular development 29107014 Circular RNA profiling reveals chi_circ_0008219 function as microRNA sponges in pre-ovulatory ovarian follicles of goats (Capra hircus). Tao H, Xiong Q, Zhang F, Zhang N, Liu Y, Suo X, Li X, Yang Q, Chen M. Genomics. 2017 Upregulated in the pre-ovulatory follicles of Macheng goat and Boer goat. qRT-PCR, RNA-seq pre-ovulatory follicles of Macheng goat and Boer goat chi_circ_0007167 circRNA capra hircus ovarian follicular development 29107014 Circular RNA profiling reveals chi_circ_0008219 function as microRNA sponges in pre-ovulatory ovarian follicles of goats (Capra hircus). Tao H, Xiong Q, Zhang F, Zhang N, Liu Y, Suo X, Li X, Yang Q, Chen M. Genomics. 2017 Upregulated in the pre-ovulatory follicles of Macheng goat and Boer goat. qRT-PCR, RNA-seq pre-ovulatory follicles of Macheng goat and Boer goat circRNA 0000552 circRNA capra hircus muscle 29228601 Genome-wide analysis of circular RNAs in prenatal and postnatal muscle of sheep. Li C, Li X, Yao Y, Ma Q, Ni W, Zhang X, Cao Y, Hazi W, Wang D, Quan R, Hou X, Liu Z, Zhan Q, Liu L, Zhang M, Yu S, Hu S. Oncotarget. 2017 We randomly selected 10 circRNAs and designed divergent primers across the circRNAs junctions. RT-PCR amplification and DNA sequencing techniques were used to confirm the circRNAs data of RNA-seq. The results of the RT-PCR amplification show a single band of the expected size. DNA sequencing results confirm the head-totail circularization splicing of these circRNAs. Real-Time RT-PCR was further used for verifying circRNAs resistance to RNase R digestion experiments. All selected 10 circRNAs showed resistance to RNase R digestion. As expected, linear control of ¦Â-Actin was sensitive to the RNase R digestion, and it was completely digested. qRT-PCR,R, RNA-seq sheep muscle circRNA 0000666 circRNA capra hircus muscle 29228601 Genome-wide analysis of circular RNAs in prenatal and postnatal muscle of sheep. Li C, Li X, Yao Y, Ma Q, Ni W, Zhang X, Cao Y, Hazi W, Wang D, Quan R, Hou X, Liu Z, Zhan Q, Liu L, Zhang M, Yu S, Hu S. Oncotarget. 2017 We randomly selected 10 circRNAs and designed divergent primers across the circRNAs junctions. RT-PCR amplification and DNA sequencing techniques were used to confirm the circRNAs data of RNA-seq. The results of the RT-PCR amplification show a single band of the expected size. DNA sequencing results confirm the head-totail circularization splicing of these circRNAs. Real-Time RT-PCR was further used for verifying circRNAs resistance to RNase R digestion experiments. All selected 10 circRNAs showed resistance to RNase R digestion. As expected, linear control of ¦Â-Actin was sensitive to the RNase R digestion, and it was completely digested. qRT-PCR, RNA-seq sheep muscle circRNA 0002456 circRNA capra hircus muscle 29228601 Genome-wide analysis of circular RNAs in prenatal and postnatal muscle of sheep. Li C, Li X, Yao Y, Ma Q, Ni W, Zhang X, Cao Y, Hazi W, Wang D, Quan R, Hou X, Liu Z, Zhan Q, Liu L, Zhang M, Yu S, Hu S. Oncotarget. 2017 We randomly selected 10 circRNAs and designed divergent primers across the circRNAs junctions. RT-PCR amplification and DNA sequencing techniques were used to confirm the circRNAs data of RNA-seq. The results of the RT-PCR amplification show a single band of the expected size. DNA sequencing results confirm the head-totail circularization splicing of these circRNAs. Real-Time RT-PCR was further used for verifying circRNAs resistance to RNase R digestion experiments. All selected 10 circRNAs showed resistance to RNase R digestion. As expected, linear control of ¦Â-Actin was sensitive to the RNase R digestion, and it was completely digested. qRT-PCR, RNA-seq sheep muscle circRNA 0003541 circRNA capra hircus muscle 29228601 Genome-wide analysis of circular RNAs in prenatal and postnatal muscle of sheep. Li C, Li X, Yao Y, Ma Q, Ni W, Zhang X, Cao Y, Hazi W, Wang D, Quan R, Hou X, Liu Z, Zhan Q, Liu L, Zhang M, Yu S, Hu S. Oncotarget. 2017 We randomly selected 10 circRNAs and designed divergent primers across the circRNAs junctions. RT-PCR amplification and DNA sequencing techniques were used to confirm the circRNAs data of RNA-seq. The results of the RT-PCR amplification show a single band of the expected size. DNA sequencing results confirm the head-totail circularization splicing of these circRNAs. Real-Time RT-PCR was further used for verifying circRNAs resistance to RNase R digestion experiments. All selected 10 circRNAs showed resistance to RNase R digestion. As expected, linear control of ¦Â-Actin was sensitive to the RNase R digestion, and it was completely digested. qRT-PCR, RNA-seq sheep muscle circRNA 0004676 circRNA capra hircus muscle 29228601 Genome-wide analysis of circular RNAs in prenatal and postnatal muscle of sheep. Li C, Li X, Yao Y, Ma Q, Ni W, Zhang X, Cao Y, Hazi W, Wang D, Quan R, Hou X, Liu Z, Zhan Q, Liu L, Zhang M, Yu S, Hu S. Oncotarget. 2017 We randomly selected 10 circRNAs and designed divergent primers across the circRNAs junctions. RT-PCR amplification and DNA sequencing techniques were used to confirm the circRNAs data of RNA-seq. The results of the RT-PCR amplification show a single band of the expected size. DNA sequencing results confirm the head-totail circularization splicing of these circRNAs. Real-Time RT-PCR was further used for verifying circRNAs resistance to RNase R digestion experiments. All selected 10 circRNAs showed resistance to RNase R digestion. As expected, linear control of ¦Â-Actin was sensitive to the RNase R digestion, and it was completely digested. qRT-PCR, RNA-seq sheep muscle circRNA 0004690 circRNA capra hircus muscle 29228601 Genome-wide analysis of circular RNAs in prenatal and postnatal muscle of sheep. Li C, Li X, Yao Y, Ma Q, Ni W, Zhang X, Cao Y, Hazi W, Wang D, Quan R, Hou X, Liu Z, Zhan Q, Liu L, Zhang M, Yu S, Hu S. Oncotarget. 2017 We randomly selected 10 circRNAs and designed divergent primers across the circRNAs junctions. RT-PCR amplification and DNA sequencing techniques were used to confirm the circRNAs data of RNA-seq. The results of the RT-PCR amplification show a single band of the expected size. DNA sequencing results confirm the head-totail circularization splicing of these circRNAs. Real-Time RT-PCR was further used for verifying circRNAs resistance to RNase R digestion experiments. All selected 10 circRNAs showed resistance to RNase R digestion. As expected, linear control of ¦Â-Actin was sensitive to the RNase R digestion, and it was completely digested. qRT-PCR, RNA-seq sheep muscle circRNA 0005179 circRNA capra hircus muscle 29228601 Genome-wide analysis of circular RNAs in prenatal and postnatal muscle of sheep. Li C, Li X, Yao Y, Ma Q, Ni W, Zhang X, Cao Y, Hazi W, Wang D, Quan R, Hou X, Liu Z, Zhan Q, Liu L, Zhang M, Yu S, Hu S. Oncotarget. 2017 We randomly selected 10 circRNAs and designed divergent primers across the circRNAs junctions. RT-PCR amplification and DNA sequencing techniques were used to confirm the circRNAs data of RNA-seq. The results of the RT-PCR amplification show a single band of the expected size. DNA sequencing results confirm the head-totail circularization splicing of these circRNAs. Real-Time RT-PCR was further used for verifying circRNAs resistance to RNase R digestion experiments. All selected 10 circRNAs showed resistance to RNase R digestion. As expected, linear control of ¦Â-Actin was sensitive to the RNase R digestion, and it was completely digested. qRT-PCR, RNA-seq sheep muscle circRNA 0005243 circRNA capra hircus muscle 29228601 Genome-wide analysis of circular RNAs in prenatal and postnatal muscle of sheep. Li C, Li X, Yao Y, Ma Q, Ni W, Zhang X, Cao Y, Hazi W, Wang D, Quan R, Hou X, Liu Z, Zhan Q, Liu L, Zhang M, Yu S, Hu S. Oncotarget. 2017 We randomly selected 10 circRNAs and designed divergent primers across the circRNAs junctions. RT-PCR amplification and DNA sequencing techniques were used to confirm the circRNAs data of RNA-seq. The results of the RT-PCR amplification show a single band of the expected size. DNA sequencing results confirm the head-totail circularization splicing of these circRNAs. Real-Time RT-PCR was further used for verifying circRNAs resistance to RNase R digestion experiments. All selected 10 circRNAs showed resistance to RNase R digestion. As expected, linear control of ¦Â-Actin was sensitive to the RNase R digestion, and it was completely digested. qRT-PCR, RNA-seq sheep muscle circRNA 0005250 circRNA capra hircus muscle 29228601 Genome-wide analysis of circular RNAs in prenatal and postnatal muscle of sheep. Li C, Li X, Yao Y, Ma Q, Ni W, Zhang X, Cao Y, Hazi W, Wang D, Quan R, Hou X, Liu Z, Zhan Q, Liu L, Zhang M, Yu S, Hu S. Oncotarget. 2017 We randomly selected 10 circRNAs and designed divergent primers across the circRNAs junctions. RT-PCR amplification and DNA sequencing techniques were used to confirm the circRNAs data of RNA-seq. The results of the RT-PCR amplification show a single band of the expected size. DNA sequencing results confirm the head-totail circularization splicing of these circRNAs. Real-Time RT-PCR was further used for verifying circRNAs resistance to RNase R digestion experiments. All selected 10 circRNAs showed resistance to RNase R digestion. As expected, linear control of ¦Â-Actin was sensitive to the RNase R digestion, and it was completely digested. qRT-PCR, RNA-seq sheep muscle circRNA 0005256 circRNA capra hircus muscle 29228601 Genome-wide analysis of circular RNAs in prenatal and postnatal muscle of sheep. Li C, Li X, Yao Y, Ma Q, Ni W, Zhang X, Cao Y, Hazi W, Wang D, Quan R, Hou X, Liu Z, Zhan Q, Liu L, Zhang M, Yu S, Hu S. Oncotarget. 2017 We randomly selected 10 circRNAs and designed divergent primers across the circRNAs junctions. RT-PCR amplification and DNA sequencing techniques were used to confirm the circRNAs data of RNA-seq. The results of the RT-PCR amplification show a single band of the expected size. DNA sequencing results confirm the head-totail circularization splicing of these circRNAs. Real-Time RT-PCR was further used for verifying circRNAs resistance to RNase R digestion experiments. All selected 10 circRNAs showed resistance to RNase R digestion. As expected, linear control of ¦Â-Actin was sensitive to the RNase R digestion, and it was completely digested. qRT-PCR, RNA-seq sheep muscle circ-0000198 circRNA capra hircus growth and development of the pituitary gland 29170496 Genome-wide analysis of circular RNAs in prenatal and postnatal pituitary glands of sheep. Li C, Li X, Ma Q, Zhang X, Cao Y, Yao Y, You S, Wang D, Quan R, Hou X, Liu Z, Zhan Q, Liu L, Zhang M, Yu S, Ni W, Hu S. Sci Rep. 2017 To confirm the data on circRNAs generated from RNA-seq analysis, we further experimentally detected the expression of sheep circRNAs. To validate our sequencing data, divergent primers were designed to amplify the circular junctions. Out of 30 randomly selected circRNAs, 29 junctions (except for circ-9563) showed the expected band sizes by RT-PCR analysis. Some reactions generated nonspecific products, which could be isoforms of alternative splicing circularization. Head-to-tail junctions were confirmed by DNA sequencing. We also tested the resistance of circRNAs to RNase R digestion by real-time RT-PCR. All five tested circRNAs showed resistance to RNase R digestion, whereas no linear ¦Â-actin mRNA was detected (sensitive to RNase R). qRT-PCR, RNA-seq sheep pituitary gland circ-0000428 circRNA capra hircus growth and development of the pituitary gland 29170496 Genome-wide analysis of circular RNAs in prenatal and postnatal pituitary glands of sheep. Li C, Li X, Ma Q, Zhang X, Cao Y, Yao Y, You S, Wang D, Quan R, Hou X, Liu Z, Zhan Q, Liu L, Zhang M, Yu S, Ni W, Hu S. Sci Rep. 2017 To confirm the data on circRNAs generated from RNA-seq analysis, we further experimentally detected the expression of sheep circRNAs. To validate our sequencing data, divergent primers were designed to amplify the circular junctions. Out of 30 randomly selected circRNAs, 29 junctions (except for circ-9563) showed the expected band sizes by RT-PCR analysis. Some reactions generated nonspecific products, which could be isoforms of alternative splicing circularization. Head-to-tail junctions were confirmed by DNA sequencing. We also tested the resistance of circRNAs to RNase R digestion by real-time RT-PCR. All five tested circRNAs showed resistance to RNase R digestion, whereas no linear ¦Â-actin mRNA was detected (sensitive to RNase R). qRT-PCR, RNA-seq sheep pituitary gland circ-0000469 circRNA capra hircus growth and development of the pituitary gland 29170496 Genome-wide analysis of circular RNAs in prenatal and postnatal pituitary glands of sheep. Li C, Li X, Ma Q, Zhang X, Cao Y, Yao Y, You S, Wang D, Quan R, Hou X, Liu Z, Zhan Q, Liu L, Zhang M, Yu S, Ni W, Hu S. Sci Rep. 2017 To confirm the data on circRNAs generated from RNA-seq analysis, we further experimentally detected the expression of sheep circRNAs. To validate our sequencing data, divergent primers were designed to amplify the circular junctions. Out of 30 randomly selected circRNAs, 29 junctions (except for circ-9563) showed the expected band sizes by RT-PCR analysis. Some reactions generated nonspecific products, which could be isoforms of alternative splicing circularization. Head-to-tail junctions were confirmed by DNA sequencing. We also tested the resistance of circRNAs to RNase R digestion by real-time RT-PCR. All five tested circRNAs showed resistance to RNase R digestion, whereas no linear ¦Â-actin mRNA was detected (sensitive to RNase R). qRT-PCR, RNA-seq sheep pituitary gland circ-0001076 circRNA capra hircus growth and development of the pituitary gland 29170496 Genome-wide analysis of circular RNAs in prenatal and postnatal pituitary glands of sheep. Li C, Li X, Ma Q, Zhang X, Cao Y, Yao Y, You S, Wang D, Quan R, Hou X, Liu Z, Zhan Q, Liu L, Zhang M, Yu S, Ni W, Hu S. Sci Rep. 2017 To confirm the data on circRNAs generated from RNA-seq analysis, we further experimentally detected the expression of sheep circRNAs. To validate our sequencing data, divergent primers were designed to amplify the circular junctions. Out of 30 randomly selected circRNAs, 29 junctions (except for circ-9563) showed the expected band sizes by RT-PCR analysis. Some reactions generated nonspecific products, which could be isoforms of alternative splicing circularization. Head-to-tail junctions were confirmed by DNA sequencing. We also tested the resistance of circRNAs to RNase R digestion by real-time RT-PCR. All five tested circRNAs showed resistance to RNase R digestion, whereas no linear ¦Â-actin mRNA was detected (sensitive to RNase R). qRT-PCR, RNA-seq sheep pituitary gland circ-0001216 circRNA capra hircus growth and development of the pituitary gland 29170496 Genome-wide analysis of circular RNAs in prenatal and postnatal pituitary glands of sheep. Li C, Li X, Ma Q, Zhang X, Cao Y, Yao Y, You S, Wang D, Quan R, Hou X, Liu Z, Zhan Q, Liu L, Zhang M, Yu S, Ni W, Hu S. Sci Rep. 2017 To confirm the data on circRNAs generated from RNA-seq analysis, we further experimentally detected the expression of sheep circRNAs. To validate our sequencing data, divergent primers were designed to amplify the circular junctions. Out of 30 randomly selected circRNAs, 29 junctions (except for circ-9563) showed the expected band sizes by RT-PCR analysis. Some reactions generated nonspecific products, which could be isoforms of alternative splicing circularization. Head-to-tail junctions were confirmed by DNA sequencing. We also tested the resistance of circRNAs to RNase R digestion by real-time RT-PCR. All five tested circRNAs showed resistance to RNase R digestion, whereas no linear ¦Â-actin mRNA was detected (sensitive to RNase R). qRT-PCR, RNA-seq sheep pituitary gland circ-0001282 circRNA capra hircus growth and development of the pituitary gland 29170496 Genome-wide analysis of circular RNAs in prenatal and postnatal pituitary glands of sheep. Li C, Li X, Ma Q, Zhang X, Cao Y, Yao Y, You S, Wang D, Quan R, Hou X, Liu Z, Zhan Q, Liu L, Zhang M, Yu S, Ni W, Hu S. Sci Rep. 2017 To confirm the data on circRNAs generated from RNA-seq analysis, we further experimentally detected the expression of sheep circRNAs. To validate our sequencing data, divergent primers were designed to amplify the circular junctions. Out of 30 randomly selected circRNAs, 29 junctions (except for circ-9563) showed the expected band sizes by RT-PCR analysis. Some reactions generated nonspecific products, which could be isoforms of alternative splicing circularization. Head-to-tail junctions were confirmed by DNA sequencing. We also tested the resistance of circRNAs to RNase R digestion by real-time RT-PCR. All five tested circRNAs showed resistance to RNase R digestion, whereas no linear ¦Â-actin mRNA was detected (sensitive to RNase R). qRT-PCR, RNA-seq sheep pituitary gland circ-0001655 circRNA capra hircus growth and development of the pituitary gland 29170496 Genome-wide analysis of circular RNAs in prenatal and postnatal pituitary glands of sheep. Li C, Li X, Ma Q, Zhang X, Cao Y, Yao Y, You S, Wang D, Quan R, Hou X, Liu Z, Zhan Q, Liu L, Zhang M, Yu S, Ni W, Hu S. Sci Rep. 2017 To confirm the data on circRNAs generated from RNA-seq analysis, we further experimentally detected the expression of sheep circRNAs. To validate our sequencing data, divergent primers were designed to amplify the circular junctions. Out of 30 randomly selected circRNAs, 29 junctions (except for circ-9563) showed the expected band sizes by RT-PCR analysis. Some reactions generated nonspecific products, which could be isoforms of alternative splicing circularization. Head-to-tail junctions were confirmed by DNA sequencing. We also tested the resistance of circRNAs to RNase R digestion by real-time RT-PCR. All five tested circRNAs showed resistance to RNase R digestion, whereas no linear ¦Â-actin mRNA was detected (sensitive to RNase R). qRT-PCR, RNA-seq sheep pituitary gland circ-0001993 circRNA capra hircus growth and development of the pituitary gland 29170496 Genome-wide analysis of circular RNAs in prenatal and postnatal pituitary glands of sheep. Li C, Li X, Ma Q, Zhang X, Cao Y, Yao Y, You S, Wang D, Quan R, Hou X, Liu Z, Zhan Q, Liu L, Zhang M, Yu S, Ni W, Hu S. Sci Rep. 2017 To confirm the data on circRNAs generated from RNA-seq analysis, we further experimentally detected the expression of sheep circRNAs. To validate our sequencing data, divergent primers were designed to amplify the circular junctions. Out of 30 randomly selected circRNAs, 29 junctions (except for circ-9563) showed the expected band sizes by RT-PCR analysis. Some reactions generated nonspecific products, which could be isoforms of alternative splicing circularization. Head-to-tail junctions were confirmed by DNA sequencing. We also tested the resistance of circRNAs to RNase R digestion by real-time RT-PCR. All five tested circRNAs showed resistance to RNase R digestion, whereas no linear ¦Â-actin mRNA was detected (sensitive to RNase R). qRT-PCR, RNA-seq sheep pituitary gland circ-0001995 circRNA capra hircus growth and development of the pituitary gland 29170496 Genome-wide analysis of circular RNAs in prenatal and postnatal pituitary glands of sheep. Li C, Li X, Ma Q, Zhang X, Cao Y, Yao Y, You S, Wang D, Quan R, Hou X, Liu Z, Zhan Q, Liu L, Zhang M, Yu S, Ni W, Hu S. Sci Rep. 2017 To confirm the data on circRNAs generated from RNA-seq analysis, we further experimentally detected the expression of sheep circRNAs. To validate our sequencing data, divergent primers were designed to amplify the circular junctions. Out of 30 randomly selected circRNAs, 29 junctions (except for circ-9563) showed the expected band sizes by RT-PCR analysis. Some reactions generated nonspecific products, which could be isoforms of alternative splicing circularization. Head-to-tail junctions were confirmed by DNA sequencing. We also tested the resistance of circRNAs to RNase R digestion by real-time RT-PCR. All five tested circRNAs showed resistance to RNase R digestion, whereas no linear ¦Â-actin mRNA was detected (sensitive to RNase R). qRT-PCR, RNA-seq sheep pituitary gland circ-0002794 circRNA capra hircus growth and development of the pituitary gland 29170496 Genome-wide analysis of circular RNAs in prenatal and postnatal pituitary glands of sheep. Li C, Li X, Ma Q, Zhang X, Cao Y, Yao Y, You S, Wang D, Quan R, Hou X, Liu Z, Zhan Q, Liu L, Zhang M, Yu S, Ni W, Hu S. Sci Rep. 2017 To confirm the data on circRNAs generated from RNA-seq analysis, we further experimentally detected the expression of sheep circRNAs. To validate our sequencing data, divergent primers were designed to amplify the circular junctions. Out of 30 randomly selected circRNAs, 29 junctions (except for circ-9563) showed the expected band sizes by RT-PCR analysis. Some reactions generated nonspecific products, which could be isoforms of alternative splicing circularization. Head-to-tail junctions were confirmed by DNA sequencing. We also tested the resistance of circRNAs to RNase R digestion by real-time RT-PCR. All five tested circRNAs showed resistance to RNase R digestion, whereas no linear ¦Â-actin mRNA was detected (sensitive to RNase R). qRT-PCR, RNA-seq sheep pituitary gland circ-0003004 circRNA capra hircus growth and development of the pituitary gland 29170496 Genome-wide analysis of circular RNAs in prenatal and postnatal pituitary glands of sheep. Li C, Li X, Ma Q, Zhang X, Cao Y, Yao Y, You S, Wang D, Quan R, Hou X, Liu Z, Zhan Q, Liu L, Zhang M, Yu S, Ni W, Hu S. Sci Rep. 2017 To confirm the data on circRNAs generated from RNA-seq analysis, we further experimentally detected the expression of sheep circRNAs. To validate our sequencing data, divergent primers were designed to amplify the circular junctions. Out of 30 randomly selected circRNAs, 29 junctions (except for circ-9563) showed the expected band sizes by RT-PCR analysis. Some reactions generated nonspecific products, which could be isoforms of alternative splicing circularization. Head-to-tail junctions were confirmed by DNA sequencing. We also tested the resistance of circRNAs to RNase R digestion by real-time RT-PCR. All five tested circRNAs showed resistance to RNase R digestion, whereas no linear ¦Â-actin mRNA was detected (sensitive to RNase R). qRT-PCR, RNA-seq sheep pituitary gland circ-0003088 circRNA capra hircus growth and development of the pituitary gland 29170496 Genome-wide analysis of circular RNAs in prenatal and postnatal pituitary glands of sheep. Li C, Li X, Ma Q, Zhang X, Cao Y, Yao Y, You S, Wang D, Quan R, Hou X, Liu Z, Zhan Q, Liu L, Zhang M, Yu S, Ni W, Hu S. Sci Rep. 2017 To confirm the data on circRNAs generated from RNA-seq analysis, we further experimentally detected the expression of sheep circRNAs. To validate our sequencing data, divergent primers were designed to amplify the circular junctions. Out of 30 randomly selected circRNAs, 29 junctions (except for circ-9563) showed the expected band sizes by RT-PCR analysis. Some reactions generated nonspecific products, which could be isoforms of alternative splicing circularization. Head-to-tail junctions were confirmed by DNA sequencing. We also tested the resistance of circRNAs to RNase R digestion by real-time RT-PCR. All five tested circRNAs showed resistance to RNase R digestion, whereas no linear ¦Â-actin mRNA was detected (sensitive to RNase R). qRT-PCR, RNA-seq sheep pituitary gland circ-0003092 circRNA capra hircus growth and development of the pituitary gland 29170496 Genome-wide analysis of circular RNAs in prenatal and postnatal pituitary glands of sheep. Li C, Li X, Ma Q, Zhang X, Cao Y, Yao Y, You S, Wang D, Quan R, Hou X, Liu Z, Zhan Q, Liu L, Zhang M, Yu S, Ni W, Hu S. Sci Rep. 2017 To confirm the data on circRNAs generated from RNA-seq analysis, we further experimentally detected the expression of sheep circRNAs. To validate our sequencing data, divergent primers were designed to amplify the circular junctions. Out of 30 randomly selected circRNAs, 29 junctions (except for circ-9563) showed the expected band sizes by RT-PCR analysis. Some reactions generated nonspecific products, which could be isoforms of alternative splicing circularization. Head-to-tail junctions were confirmed by DNA sequencing. We also tested the resistance of circRNAs to RNase R digestion by real-time RT-PCR. All five tested circRNAs showed resistance to RNase R digestion, whereas no linear ¦Â-actin mRNA was detected (sensitive to RNase R). qRT-PCR, RNA-seq sheep pituitary gland circ-0003094 circRNA capra hircus growth and development of the pituitary gland 29170496 Genome-wide analysis of circular RNAs in prenatal and postnatal pituitary glands of sheep. Li C, Li X, Ma Q, Zhang X, Cao Y, Yao Y, You S, Wang D, Quan R, Hou X, Liu Z, Zhan Q, Liu L, Zhang M, Yu S, Ni W, Hu S. Sci Rep. 2017 To confirm the data on circRNAs generated from RNA-seq analysis, we further experimentally detected the expression of sheep circRNAs. To validate our sequencing data, divergent primers were designed to amplify the circular junctions. Out of 30 randomly selected circRNAs, 29 junctions (except for circ-9563) showed the expected band sizes by RT-PCR analysis. Some reactions generated nonspecific products, which could be isoforms of alternative splicing circularization. Head-to-tail junctions were confirmed by DNA sequencing. We also tested the resistance of circRNAs to RNase R digestion by real-time RT-PCR. All five tested circRNAs showed resistance to RNase R digestion, whereas no linear ¦Â-actin mRNA was detected (sensitive to RNase R). qRT-PCR, RNA-seq sheep pituitary gland circ-0003479 circRNA capra hircus growth and development of the pituitary gland 29170496 Genome-wide analysis of circular RNAs in prenatal and postnatal pituitary glands of sheep. Li C, Li X, Ma Q, Zhang X, Cao Y, Yao Y, You S, Wang D, Quan R, Hou X, Liu Z, Zhan Q, Liu L, Zhang M, Yu S, Ni W, Hu S. Sci Rep. 2017 To confirm the data on circRNAs generated from RNA-seq analysis, we further experimentally detected the expression of sheep circRNAs. To validate our sequencing data, divergent primers were designed to amplify the circular junctions. Out of 30 randomly selected circRNAs, 29 junctions (except for circ-9563) showed the expected band sizes by RT-PCR analysis. Some reactions generated nonspecific products, which could be isoforms of alternative splicing circularization. Head-to-tail junctions were confirmed by DNA sequencing. We also tested the resistance of circRNAs to RNase R digestion by real-time RT-PCR. All five tested circRNAs showed resistance to RNase R digestion, whereas no linear ¦Â-actin mRNA was detected (sensitive to RNase R). qRT-PCR, RNA-seq sheep pituitary gland circ-0004352 circRNA capra hircus growth and development of the pituitary gland 29170496 Genome-wide analysis of circular RNAs in prenatal and postnatal pituitary glands of sheep. Li C, Li X, Ma Q, Zhang X, Cao Y, Yao Y, You S, Wang D, Quan R, Hou X, Liu Z, Zhan Q, Liu L, Zhang M, Yu S, Ni W, Hu S. Sci Rep. 2017 To confirm the data on circRNAs generated from RNA-seq analysis, we further experimentally detected the expression of sheep circRNAs. To validate our sequencing data, divergent primers were designed to amplify the circular junctions. Out of 30 randomly selected circRNAs, 29 junctions (except for circ-9563) showed the expected band sizes by RT-PCR analysis. Some reactions generated nonspecific products, which could be isoforms of alternative splicing circularization. Head-to-tail junctions were confirmed by DNA sequencing. We also tested the resistance of circRNAs to RNase R digestion by real-time RT-PCR. All five tested circRNAs showed resistance to RNase R digestion, whereas no linear ¦Â-actin mRNA was detected (sensitive to RNase R). qRT-PCR, RNA-seq sheep pituitary gland circ-0004460 circRNA capra hircus growth and development of the pituitary gland 29170496 Genome-wide analysis of circular RNAs in prenatal and postnatal pituitary glands of sheep. Li C, Li X, Ma Q, Zhang X, Cao Y, Yao Y, You S, Wang D, Quan R, Hou X, Liu Z, Zhan Q, Liu L, Zhang M, Yu S, Ni W, Hu S. Sci Rep. 2017 To confirm the data on circRNAs generated from RNA-seq analysis, we further experimentally detected the expression of sheep circRNAs. To validate our sequencing data, divergent primers were designed to amplify the circular junctions. Out of 30 randomly selected circRNAs, 29 junctions (except for circ-9563) showed the expected band sizes by RT-PCR analysis. Some reactions generated nonspecific products, which could be isoforms of alternative splicing circularization. Head-to-tail junctions were confirmed by DNA sequencing. We also tested the resistance of circRNAs to RNase R digestion by real-time RT-PCR. All five tested circRNAs showed resistance to RNase R digestion, whereas no linear ¦Â-actin mRNA was detected (sensitive to RNase R). qRT-PCR, RNA-seq sheep pituitary gland circ-0004489 circRNA capra hircus growth and development of the pituitary gland 29170496 Genome-wide analysis of circular RNAs in prenatal and postnatal pituitary glands of sheep. Li C, Li X, Ma Q, Zhang X, Cao Y, Yao Y, You S, Wang D, Quan R, Hou X, Liu Z, Zhan Q, Liu L, Zhang M, Yu S, Ni W, Hu S. Sci Rep. 2017 To confirm the data on circRNAs generated from RNA-seq analysis, we further experimentally detected the expression of sheep circRNAs. To validate our sequencing data, divergent primers were designed to amplify the circular junctions. Out of 30 randomly selected circRNAs, 29 junctions (except for circ-9563) showed the expected band sizes by RT-PCR analysis. Some reactions generated nonspecific products, which could be isoforms of alternative splicing circularization. Head-to-tail junctions were confirmed by DNA sequencing. We also tested the resistance of circRNAs to RNase R digestion by real-time RT-PCR. All five tested circRNAs showed resistance to RNase R digestion, whereas no linear ¦Â-actin mRNA was detected (sensitive to RNase R). qRT-PCR, RNA-seq sheep pituitary gland circ-0004723 circRNA capra hircus growth and development of the pituitary gland 29170496 Genome-wide analysis of circular RNAs in prenatal and postnatal pituitary glands of sheep. Li C, Li X, Ma Q, Zhang X, Cao Y, Yao Y, You S, Wang D, Quan R, Hou X, Liu Z, Zhan Q, Liu L, Zhang M, Yu S, Ni W, Hu S. Sci Rep. 2017 To confirm the data on circRNAs generated from RNA-seq analysis, we further experimentally detected the expression of sheep circRNAs. To validate our sequencing data, divergent primers were designed to amplify the circular junctions. Out of 30 randomly selected circRNAs, 29 junctions (except for circ-9563) showed the expected band sizes by RT-PCR analysis. Some reactions generated nonspecific products, which could be isoforms of alternative splicing circularization. Head-to-tail junctions were confirmed by DNA sequencing. We also tested the resistance of circRNAs to RNase R digestion by real-time RT-PCR. All five tested circRNAs showed resistance to RNase R digestion, whereas no linear ¦Â-actin mRNA was detected (sensitive to RNase R). qRT-PCR, RNA-seq sheep pituitary gland circ-0005181 circRNA capra hircus growth and development of the pituitary gland 29170496 Genome-wide analysis of circular RNAs in prenatal and postnatal pituitary glands of sheep. Li C, Li X, Ma Q, Zhang X, Cao Y, Yao Y, You S, Wang D, Quan R, Hou X, Liu Z, Zhan Q, Liu L, Zhang M, Yu S, Ni W, Hu S. Sci Rep. 2017 To confirm the data on circRNAs generated from RNA-seq analysis, we further experimentally detected the expression of sheep circRNAs. To validate our sequencing data, divergent primers were designed to amplify the circular junctions. Out of 30 randomly selected circRNAs, 29 junctions (except for circ-9563) showed the expected band sizes by RT-PCR analysis. Some reactions generated nonspecific products, which could be isoforms of alternative splicing circularization. Head-to-tail junctions were confirmed by DNA sequencing. We also tested the resistance of circRNAs to RNase R digestion by real-time RT-PCR. All five tested circRNAs showed resistance to RNase R digestion, whereas no linear ¦Â-actin mRNA was detected (sensitive to RNase R). qRT-PCR, RNA-seq sheep pituitary gland circ-0005695 circRNA capra hircus growth and development of the pituitary gland 29170496 Genome-wide analysis of circular RNAs in prenatal and postnatal pituitary glands of sheep. Li C, Li X, Ma Q, Zhang X, Cao Y, Yao Y, You S, Wang D, Quan R, Hou X, Liu Z, Zhan Q, Liu L, Zhang M, Yu S, Ni W, Hu S. Sci Rep. 2017 To confirm the data on circRNAs generated from RNA-seq analysis, we further experimentally detected the expression of sheep circRNAs. To validate our sequencing data, divergent primers were designed to amplify the circular junctions. Out of 30 randomly selected circRNAs, 29 junctions (except for circ-9563) showed the expected band sizes by RT-PCR analysis. Some reactions generated nonspecific products, which could be isoforms of alternative splicing circularization. Head-to-tail junctions were confirmed by DNA sequencing. We also tested the resistance of circRNAs to RNase R digestion by real-time RT-PCR. All five tested circRNAs showed resistance to RNase R digestion, whereas no linear ¦Â-actin mRNA was detected (sensitive to RNase R). qRT-PCR, RNA-seq sheep pituitary gland circ-0005738 circRNA capra hircus growth and development of the pituitary gland 29170496 Genome-wide analysis of circular RNAs in prenatal and postnatal pituitary glands of sheep. Li C, Li X, Ma Q, Zhang X, Cao Y, Yao Y, You S, Wang D, Quan R, Hou X, Liu Z, Zhan Q, Liu L, Zhang M, Yu S, Ni W, Hu S. Sci Rep. 2017 To confirm the data on circRNAs generated from RNA-seq analysis, we further experimentally detected the expression of sheep circRNAs. To validate our sequencing data, divergent primers were designed to amplify the circular junctions. Out of 30 randomly selected circRNAs, 29 junctions (except for circ-9563) showed the expected band sizes by RT-PCR analysis. Some reactions generated nonspecific products, which could be isoforms of alternative splicing circularization. Head-to-tail junctions were confirmed by DNA sequencing. We also tested the resistance of circRNAs to RNase R digestion by real-time RT-PCR. All five tested circRNAs showed resistance to RNase R digestion, whereas no linear ¦Â-actin mRNA was detected (sensitive to RNase R). qRT-PCR, RNA-seq sheep pituitary gland circ-0006581 circRNA capra hircus growth and development of the pituitary gland 29170496 Genome-wide analysis of circular RNAs in prenatal and postnatal pituitary glands of sheep. Li C, Li X, Ma Q, Zhang X, Cao Y, Yao Y, You S, Wang D, Quan R, Hou X, Liu Z, Zhan Q, Liu L, Zhang M, Yu S, Ni W, Hu S. Sci Rep. 2017 To confirm the data on circRNAs generated from RNA-seq analysis, we further experimentally detected the expression of sheep circRNAs. To validate our sequencing data, divergent primers were designed to amplify the circular junctions. Out of 30 randomly selected circRNAs, 29 junctions (except for circ-9563) showed the expected band sizes by RT-PCR analysis. Some reactions generated nonspecific products, which could be isoforms of alternative splicing circularization. Head-to-tail junctions were confirmed by DNA sequencing. We also tested the resistance of circRNAs to RNase R digestion by real-time RT-PCR. All five tested circRNAs showed resistance to RNase R digestion, whereas no linear ¦Â-actin mRNA was detected (sensitive to RNase R). qRT-PCR, RNA-seq sheep pituitary gland circ-0007204 circRNA capra hircus growth and development of the pituitary gland 29170496 Genome-wide analysis of circular RNAs in prenatal and postnatal pituitary glands of sheep. Li C, Li X, Ma Q, Zhang X, Cao Y, Yao Y, You S, Wang D, Quan R, Hou X, Liu Z, Zhan Q, Liu L, Zhang M, Yu S, Ni W, Hu S. Sci Rep. 2017 To confirm the data on circRNAs generated from RNA-seq analysis, we further experimentally detected the expression of sheep circRNAs. To validate our sequencing data, divergent primers were designed to amplify the circular junctions. Out of 30 randomly selected circRNAs, 29 junctions (except for circ-9563) showed the expected band sizes by RT-PCR analysis. Some reactions generated nonspecific products, which could be isoforms of alternative splicing circularization. Head-to-tail junctions were confirmed by DNA sequencing. We also tested the resistance of circRNAs to RNase R digestion by real-time RT-PCR. All five tested circRNAs showed resistance to RNase R digestion, whereas no linear ¦Â-actin mRNA was detected (sensitive to RNase R). qRT-PCR, RNA-seq sheep pituitary gland circ-0007336 circRNA capra hircus growth and development of the pituitary gland 29170496 Genome-wide analysis of circular RNAs in prenatal and postnatal pituitary glands of sheep. Li C, Li X, Ma Q, Zhang X, Cao Y, Yao Y, You S, Wang D, Quan R, Hou X, Liu Z, Zhan Q, Liu L, Zhang M, Yu S, Ni W, Hu S. Sci Rep. 2017 To confirm the data on circRNAs generated from RNA-seq analysis, we further experimentally detected the expression of sheep circRNAs. To validate our sequencing data, divergent primers were designed to amplify the circular junctions. Out of 30 randomly selected circRNAs, 29 junctions (except for circ-9563) showed the expected band sizes by RT-PCR analysis. Some reactions generated nonspecific products, which could be isoforms of alternative splicing circularization. Head-to-tail junctions were confirmed by DNA sequencing. We also tested the resistance of circRNAs to RNase R digestion by real-time RT-PCR. All five tested circRNAs showed resistance to RNase R digestion, whereas no linear ¦Â-actin mRNA was detected (sensitive to RNase R). qRT-PCR, RNA-seq sheep pituitary gland circ-0007685 circRNA capra hircus growth and development of the pituitary gland 29170496 Genome-wide analysis of circular RNAs in prenatal and postnatal pituitary glands of sheep. Li C, Li X, Ma Q, Zhang X, Cao Y, Yao Y, You S, Wang D, Quan R, Hou X, Liu Z, Zhan Q, Liu L, Zhang M, Yu S, Ni W, Hu S. Sci Rep. 2017 To confirm the data on circRNAs generated from RNA-seq analysis, we further experimentally detected the expression of sheep circRNAs. To validate our sequencing data, divergent primers were designed to amplify the circular junctions. Out of 30 randomly selected circRNAs, 29 junctions (except for circ-9563) showed the expected band sizes by RT-PCR analysis. Some reactions generated nonspecific products, which could be isoforms of alternative splicing circularization. Head-to-tail junctions were confirmed by DNA sequencing. We also tested the resistance of circRNAs to RNase R digestion by real-time RT-PCR. All five tested circRNAs showed resistance to RNase R digestion, whereas no linear ¦Â-actin mRNA was detected (sensitive to RNase R). qRT-PCR, RNA-seq sheep pituitary gland circ-0007685 circRNA capra hircus growth and development of the pituitary gland 29170496 Genome-wide analysis of circular RNAs in prenatal and postnatal pituitary glands of sheep. Li C, Li X, Ma Q, Zhang X, Cao Y, Yao Y, You S, Wang D, Quan R, Hou X, Liu Z, Zhan Q, Liu L, Zhang M, Yu S, Ni W, Hu S. Sci Rep. 2017 To confirm the data on circRNAs generated from RNA-seq analysis, we further experimentally detected the expression of sheep circRNAs. To validate our sequencing data, divergent primers were designed to amplify the circular junctions. Out of 30 randomly selected circRNAs, 29 junctions (except for circ-9563) showed the expected band sizes by RT-PCR analysis. Some reactions generated nonspecific products, which could be isoforms of alternative splicing circularization. Head-to-tail junctions were confirmed by DNA sequencing. We also tested the resistance of circRNAs to RNase R digestion by real-time RT-PCR. All five tested circRNAs showed resistance to RNase R digestion, whereas no linear ¦Â-actin mRNA was detected (sensitive to RNase R). qRT-PCR, RNA-seq sheep pituitary gland circ-0008710 circRNA capra hircus growth and development of the pituitary gland 29170496 Genome-wide analysis of circular RNAs in prenatal and postnatal pituitary glands of sheep. Li C, Li X, Ma Q, Zhang X, Cao Y, Yao Y, You S, Wang D, Quan R, Hou X, Liu Z, Zhan Q, Liu L, Zhang M, Yu S, Ni W, Hu S. Sci Rep. 2017 To confirm the data on circRNAs generated from RNA-seq analysis, we further experimentally detected the expression of sheep circRNAs. To validate our sequencing data, divergent primers were designed to amplify the circular junctions. Out of 30 randomly selected circRNAs, 29 junctions (except for circ-9563) showed the expected band sizes by RT-PCR analysis. Some reactions generated nonspecific products, which could be isoforms of alternative splicing circularization. Head-to-tail junctions were confirmed by DNA sequencing. We also tested the resistance of circRNAs to RNase R digestion by real-time RT-PCR. All five tested circRNAs showed resistance to RNase R digestion, whereas no linear ¦Â-actin mRNA was detected (sensitive to RNase R). qRT-PCR, RNA-seq sheep pituitary gland circ-0009865 circRNA capra hircus growth and development of the pituitary gland 29170496 Genome-wide analysis of circular RNAs in prenatal and postnatal pituitary glands of sheep. Li C, Li X, Ma Q, Zhang X, Cao Y, Yao Y, You S, Wang D, Quan R, Hou X, Liu Z, Zhan Q, Liu L, Zhang M, Yu S, Ni W, Hu S. Sci Rep. 2017 To confirm the data on circRNAs generated from RNA-seq analysis, we further experimentally detected the expression of sheep circRNAs. To validate our sequencing data, divergent primers were designed to amplify the circular junctions. Out of 30 randomly selected circRNAs, 29 junctions (except for circ-9563) showed the expected band sizes by RT-PCR analysis. Some reactions generated nonspecific products, which could be isoforms of alternative splicing circularization. Head-to-tail junctions were confirmed by DNA sequencing. We also tested the resistance of circRNAs to RNase R digestion by real-time RT-PCR. All five tested circRNAs showed resistance to RNase R digestion, whereas no linear ¦Â-actin mRNA was detected (sensitive to RNase R). qRT-PCR, RNA-seq sheep pituitary gland bmo_circ_0000129 circRNA bombyx mori bmo_circ_0000129 silk gland 28918159 Identification of circular RNA in the Bombyx mori silk gland. Gan H, Feng T, Wu Y, Liu C, Xia Q, Cheng T. Insect Biochem Mol Biol. 2017 We further experimentally validated the candidate B. mori circRNAs. Convergent and divergent primers were designed to amplify each circRNA in the RNase R-treated sample (cDNA) and genomic DNA. Convergent primers were designed as a positive control for the corresponding linear transcripts, and divergent primers were designed to detect the circular template. Theoretically, convergent primers should amplify products from both the cDNA and genomic DNA, whereas the divergent primers would only amplify circRNA from cDNA and would fail to amplify a product from the genomic DNA. The reverse transcription PCR amplification results showed that 16 of 38 randomly chosen circRNA were validated successfully. RT-PCR, RNA-seq middle silk gland (MSG) and posterior silk gland (PSG) bmo_circ_0000131 circRNA bombyx mori bmo_circ_0000131 silk gland 28918159 Identification of circular RNA in the Bombyx mori silk gland. Gan H, Feng T, Wu Y, Liu C, Xia Q, Cheng T. Insect Biochem Mol Biol. 2017 We further experimentally validated the candidate B. mori circRNAs. Convergent and divergent primers were designed to amplify each circRNA in the RNase R-treated sample (cDNA) and genomic DNA. Convergent primers were designed as a positive control for the corresponding linear transcripts, and divergent primers were designed to detect the circular template. Theoretically, convergent primers should amplify products from both the cDNA and genomic DNA, whereas the divergent primers would only amplify circRNA from cDNA and would fail to amplify a product from the genomic DNA. The reverse transcription PCR amplification results showed that 16 of 38 randomly chosen circRNA were validated successfully. RT-PCR, RNA-seq middle silk gland (MSG) and posterior silk gland (PSG) bmo_circ_0000257 circRNA bombyx mori bmo_circ_0000257 silk gland 28918159 Identification of circular RNA in the Bombyx mori silk gland. Gan H, Feng T, Wu Y, Liu C, Xia Q, Cheng T. Insect Biochem Mol Biol. 2017 We further experimentally validated the candidate B. mori circRNAs. Convergent and divergent primers were designed to amplify each circRNA in the RNase R-treated sample (cDNA) and genomic DNA. Convergent primers were designed as a positive control for the corresponding linear transcripts, and divergent primers were designed to detect the circular template. Theoretically, convergent primers should amplify products from both the cDNA and genomic DNA, whereas the divergent primers would only amplify circRNA from cDNA and would fail to amplify a product from the genomic DNA. The reverse transcription PCR amplification results showed that 16 of 38 randomly chosen circRNA were validated successfully. RT-PCR, RNA-seq middle silk gland (MSG) and posterior silk gland (PSG) bmo_circ_0000654 circRNA bombyx mori bmo_circ_0000654 silk gland 28918159 Identification of circular RNA in the Bombyx mori silk gland. Gan H, Feng T, Wu Y, Liu C, Xia Q, Cheng T. Insect Biochem Mol Biol. 2017 upregulated in the MSG. qRT-PCR,RNA-seq middle silk gland (MSG) and posterior silk gland (PSG) bmo_circ_0000674 circRNA bombyx mori bmo_circ_0000674 silk gland 28918159 Identification of circular RNA in the Bombyx mori silk gland. Gan H, Feng T, Wu Y, Liu C, Xia Q, Cheng T. Insect Biochem Mol Biol. 2017 We further experimentally validated the candidate B. mori circRNAs. Convergent and divergent primers were designed to amplify each circRNA in the RNase R-treated sample (cDNA) and genomic DNA. Convergent primers were designed as a positive control for the corresponding linear transcripts, and divergent primers were designed to detect the circular template. Theoretically, convergent primers should amplify products from both the cDNA and genomic DNA, whereas the divergent primers would only amplify circRNA from cDNA and would fail to amplify a product from the genomic DNA. The reverse transcription PCR amplification results showed that 16 of 38 randomly chosen circRNA were validated successfully. RT-PCR, RNA-seq middle silk gland (MSG) and posterior silk gland (PSG) bmo_circ_0000681 circRNA bombyx mori bmo_circ_0000681 silk gland 28918159 Identification of circular RNA in the Bombyx mori silk gland. Gan H, Feng T, Wu Y, Liu C, Xia Q, Cheng T. Insect Biochem Mol Biol. 2017 We further experimentally validated the candidate B. mori circRNAs. Convergent and divergent primers were designed to amplify each circRNA in the RNase R-treated sample (cDNA) and genomic DNA. Convergent primers were designed as a positive control for the corresponding linear transcripts, and divergent primers were designed to detect the circular template. Theoretically, convergent primers should amplify products from both the cDNA and genomic DNA, whereas the divergent primers would only amplify circRNA from cDNA and would fail to amplify a product from the genomic DNA. The reverse transcription PCR amplification results showed that 16 of 38 randomly chosen circRNA were validated successfully. RT-PCR, RNA-seq middle silk gland (MSG) and posterior silk gland (PSG) bmo_circ_0000832 circRNA bombyx mori bmo_circ_0000832 silk gland 28918159 Identification of circular RNA in the Bombyx mori silk gland. Gan H, Feng T, Wu Y, Liu C, Xia Q, Cheng T. Insect Biochem Mol Biol. 2017 upregulated in the MSG. qRT-PCR,RNA-seq middle silk gland (MSG) and posterior silk gland (PSG) bmo_circ_0000861 circRNA bombyx mori bmo_circ_0000861 silk gland 28918159 Identification of circular RNA in the Bombyx mori silk gland. Gan H, Feng T, Wu Y, Liu C, Xia Q, Cheng T. Insect Biochem Mol Biol. 2017 upregulated in the MSG. qRT-PCR,RNA-seq middle silk gland (MSG) and posterior silk gland (PSG) bmo_circ_0001406 circRNA bombyx mori bmo_circ_0001406 silk gland 28918159 Identification of circular RNA in the Bombyx mori silk gland. Gan H, Feng T, Wu Y, Liu C, Xia Q, Cheng T. Insect Biochem Mol Biol. 2017 upregulated in the PSG. qRT-PCR,RNA-seq middle silk gland (MSG) and posterior silk gland (PSG) bmo_circ_0001417 circRNA bombyx mori bmo_circ_0001417 silk gland 28918159 Identification of circular RNA in the Bombyx mori silk gland. Gan H, Feng T, Wu Y, Liu C, Xia Q, Cheng T. Insect Biochem Mol Biol. 2017 upregulated in the PSG. qRT-PCR,RNA-seq middle silk gland (MSG) and posterior silk gland (PSG) bmo_circ_0001422 circRNA bombyx mori bmo_circ_0001422 silk gland 28918159 Identification of circular RNA in the Bombyx mori silk gland. Gan H, Feng T, Wu Y, Liu C, Xia Q, Cheng T. Insect Biochem Mol Biol. 2017 upregulated in the PSG. qRT-PCR,RNA-seq middle silk gland (MSG) and posterior silk gland (PSG) bmo_circ_0001433 circRNA bombyx mori bmo_circ_0001433 silk gland 28918159 Identification of circular RNA in the Bombyx mori silk gland. Gan H, Feng T, Wu Y, Liu C, Xia Q, Cheng T. Insect Biochem Mol Biol. 2017 upregulated in the PSG. qRT-PCR,RNA-seq middle silk gland (MSG) and posterior silk gland (PSG) bmo_circ_0001436 circRNA bombyx mori bmo_circ_0001436 silk gland 28918159 Identification of circular RNA in the Bombyx mori silk gland. Gan H, Feng T, Wu Y, Liu C, Xia Q, Cheng T. Insect Biochem Mol Biol. 2017 upregulated in the PSG. qRT-PCR,RNA-seq middle silk gland (MSG) and posterior silk gland (PSG) bmo_circ_0001437 circRNA bombyx mori bmo_circ_0001437 silk gland 28918159 Identification of circular RNA in the Bombyx mori silk gland. Gan H, Feng T, Wu Y, Liu C, Xia Q, Cheng T. Insect Biochem Mol Biol. 2017 upregulated in the PSG. qRT-PCR,RNA-seq middle silk gland (MSG) and posterior silk gland (PSG) bmo_circ_0001438 circRNA bombyx mori bmo_circ_0001438 silk gland 28918159 Identification of circular RNA in the Bombyx mori silk gland. Gan H, Feng T, Wu Y, Liu C, Xia Q, Cheng T. Insect Biochem Mol Biol. 2017 upregulated in the PSG. qRT-PCR,RNA-seq middle silk gland (MSG) and posterior silk gland (PSG) bmo_circ_0001555 circRNA bombyx mori bmo_circ_0001555 silk gland 28918159 Identification of circular RNA in the Bombyx mori silk gland. Gan H, Feng T, Wu Y, Liu C, Xia Q, Cheng T. Insect Biochem Mol Biol. 2017 We further experimentally validated the candidate B. mori circRNAs. Convergent and divergent primers were designed to amplify each circRNA in the RNase R-treated sample (cDNA) and genomic DNA. Convergent primers were designed as a positive control for the corresponding linear transcripts, and divergent primers were designed to detect the circular template. Theoretically, convergent primers should amplify products from both the cDNA and genomic DNA, whereas the divergent primers would only amplify circRNA from cDNA and would fail to amplify a product from the genomic DNA. The reverse transcription PCR amplification results showed that 16 of 38 randomly chosen circRNA were validated successfully. RT-PCR, RNA-seq middle silk gland (MSG) and posterior silk gland (PSG) bmo_circ_0001612 circRNA bombyx mori bmo_circ_0001612 silk gland 28918159 Identification of circular RNA in the Bombyx mori silk gland. Gan H, Feng T, Wu Y, Liu C, Xia Q, Cheng T. Insect Biochem Mol Biol. 2017 We further experimentally validated the candidate B. mori circRNAs. Convergent and divergent primers were designed to amplify each circRNA in the RNase R-treated sample (cDNA) and genomic DNA. Convergent primers were designed as a positive control for the corresponding linear transcripts, and divergent primers were designed to detect the circular template. Theoretically, convergent primers should amplify products from both the cDNA and genomic DNA, whereas the divergent primers would only amplify circRNA from cDNA and would fail to amplify a product from the genomic DNA. The reverse transcription PCR amplification results showed that 16 of 38 randomly chosen circRNA were validated successfully. RT-PCR, RNA-seq middle silk gland (MSG) and posterior silk gland (PSG) bmo_circ_0002031 circRNA bombyx mori bmo_circ_0002031 silk gland 28918159 Identification of circular RNA in the Bombyx mori silk gland. Gan H, Feng T, Wu Y, Liu C, Xia Q, Cheng T. Insect Biochem Mol Biol. 2017 We further experimentally validated the candidate B. mori circRNAs. Convergent and divergent primers were designed to amplify each circRNA in the RNase R-treated sample (cDNA) and genomic DNA. Convergent primers were designed as a positive control for the corresponding linear transcripts, and divergent primers were designed to detect the circular template. Theoretically, convergent primers should amplify products from both the cDNA and genomic DNA, whereas the divergent primers would only amplify circRNA from cDNA and would fail to amplify a product from the genomic DNA. The reverse transcription PCR amplification results showed that 16 of 38 randomly chosen circRNA were validated successfully. RT-PCR, RNA-seq middle silk gland (MSG) and posterior silk gland (PSG) bmo_circ_0002094 circRNA bombyx mori bmo_circ_0002094 silk gland 28918159 Identification of circular RNA in the Bombyx mori silk gland. Gan H, Feng T, Wu Y, Liu C, Xia Q, Cheng T. Insect Biochem Mol Biol. 2017 We further experimentally validated the candidate B. mori circRNAs. Convergent and divergent primers were designed to amplify each circRNA in the RNase R-treated sample (cDNA) and genomic DNA. Convergent primers were designed as a positive control for the corresponding linear transcripts, and divergent primers were designed to detect the circular template. Theoretically, convergent primers should amplify products from both the cDNA and genomic DNA, whereas the divergent primers would only amplify circRNA from cDNA and would fail to amplify a product from the genomic DNA. The reverse transcription PCR amplification results showed that 16 of 38 randomly chosen circRNA were validated successfully. RT-PCR, RNA-seq middle silk gland (MSG) and posterior silk gland (PSG) bmo_circ_0002123 circRNA bombyx mori bmo_circ_0002123 silk gland 28918159 Identification of circular RNA in the Bombyx mori silk gland. Gan H, Feng T, Wu Y, Liu C, Xia Q, Cheng T. Insect Biochem Mol Biol. 2017 We further experimentally validated the candidate B. mori circRNAs. Convergent and divergent primers were designed to amplify each circRNA in the RNase R-treated sample (cDNA) and genomic DNA. Convergent primers were designed as a positive control for the corresponding linear transcripts, and divergent primers were designed to detect the circular template. Theoretically, convergent primers should amplify products from both the cDNA and genomic DNA, whereas the divergent primers would only amplify circRNA from cDNA and would fail to amplify a product from the genomic DNA. The reverse transcription PCR amplification results showed that 16 of 38 randomly chosen circRNA were validated successfully. RT-PCR, RNA-seq middle silk gland (MSG) and posterior silk gland (PSG) bmo_circ_0002204 circRNA bombyx mori bmo_circ_0002204 silk gland 28918159 Identification of circular RNA in the Bombyx mori silk gland. Gan H, Feng T, Wu Y, Liu C, Xia Q, Cheng T. Insect Biochem Mol Biol. 2017 upregulated in the PSG. qRT-PCR,RNA-seq middle silk gland (MSG) and posterior silk gland (PSG) bmo_circ_0002365 circRNA bombyx mori bmo_circ_0002365 silk gland 28918159 Identification of circular RNA in the Bombyx mori silk gland. Gan H, Feng T, Wu Y, Liu C, Xia Q, Cheng T. Insect Biochem Mol Biol. 2017 We further experimentally validated the candidate B. mori circRNAs. Convergent and divergent primers were designed to amplify each circRNA in the RNase R-treated sample (cDNA) and genomic DNA. Convergent primers were designed as a positive control for the corresponding linear transcripts, and divergent primers were designed to detect the circular template. Theoretically, convergent primers should amplify products from both the cDNA and genomic DNA, whereas the divergent primers would only amplify circRNA from cDNA and would fail to amplify a product from the genomic DNA. The reverse transcription PCR amplification results showed that 16 of 38 randomly chosen circRNA were validated successfully. RT-PCR, RNA-seq middle silk gland (MSG) and posterior silk gland (PSG) bmo_circ_0002389 circRNA bombyx mori bmo_circ_0002389 silk gland 28918159 Identification of circular RNA in the Bombyx mori silk gland. Gan H, Feng T, Wu Y, Liu C, Xia Q, Cheng T. Insect Biochem Mol Biol. 2017 upregulated in the MSG. qRT-PCR,RNA-seq middle silk gland (MSG) and posterior silk gland (PSG) bmo_circ_0002460 circRNA bombyx mori bmo_circ_0002460 silk gland 28918159 Identification of circular RNA in the Bombyx mori silk gland. Gan H, Feng T, Wu Y, Liu C, Xia Q, Cheng T. Insect Biochem Mol Biol. 2017 We further experimentally validated the candidate B. mori circRNAs. Convergent and divergent primers were designed to amplify each circRNA in the RNase R-treated sample (cDNA) and genomic DNA. Convergent primers were designed as a positive control for the corresponding linear transcripts, and divergent primers were designed to detect the circular template. Theoretically, convergent primers should amplify products from both the cDNA and genomic DNA, whereas the divergent primers would only amplify circRNA from cDNA and would fail to amplify a product from the genomic DNA. The reverse transcription PCR amplification results showed that 16 of 38 randomly chosen circRNA were validated successfully. RT-PCR, RNA-seq middle silk gland (MSG) and posterior silk gland (PSG) bmo_circ_0002462 circRNA bombyx mori bmo_circ_0002462 silk gland 28918159 Identification of circular RNA in the Bombyx mori silk gland. Gan H, Feng T, Wu Y, Liu C, Xia Q, Cheng T. Insect Biochem Mol Biol. 2017 upregulated in the MSG. qRT-PCR,RNA-seq middle silk gland (MSG) and posterior silk gland (PSG) bmo_circ_0002508 circRNA bombyx mori bmo_circ_0002508 silk gland 28918159 Identification of circular RNA in the Bombyx mori silk gland. Gan H, Feng T, Wu Y, Liu C, Xia Q, Cheng T. Insect Biochem Mol Biol. 2017 We further experimentally validated the candidate B. mori circRNAs. Convergent and divergent primers were designed to amplify each circRNA in the RNase R-treated sample (cDNA) and genomic DNA. Convergent primers were designed as a positive control for the corresponding linear transcripts, and divergent primers were designed to detect the circular template. Theoretically, convergent primers should amplify products from both the cDNA and genomic DNA, whereas the divergent primers would only amplify circRNA from cDNA and would fail to amplify a product from the genomic DNA. The reverse transcription PCR amplification results showed that 16 of 38 randomly chosen circRNA were validated successfully. RT-PCR, RNA-seq middle silk gland (MSG) and posterior silk gland (PSG) bmo_circ_0002742 circRNA bombyx mori bmo_circ_0002742 silk gland 28918159 Identification of circular RNA in the Bombyx mori silk gland. Gan H, Feng T, Wu Y, Liu C, Xia Q, Cheng T. Insect Biochem Mol Biol. 2017 We further experimentally validated the candidate B. mori circRNAs. Convergent and divergent primers were designed to amplify each circRNA in the RNase R-treated sample (cDNA) and genomic DNA. Convergent primers were designed as a positive control for the corresponding linear transcripts, and divergent primers were designed to detect the circular template. Theoretically, convergent primers should amplify products from both the cDNA and genomic DNA, whereas the divergent primers would only amplify circRNA from cDNA and would fail to amplify a product from the genomic DNA. The reverse transcription PCR amplification results showed that 16 of 38 randomly chosen circRNA were validated successfully. upregulated in the MSG. RT-PCR,qRT-PCR,RNA-seq middle silk gland (MSG) and posterior silk gland (PSG) bmo_circ_0003025 circRNA bombyx mori bmo_circ_0003025 silk gland 28918159 Identification of circular RNA in the Bombyx mori silk gland. Gan H, Feng T, Wu Y, Liu C, Xia Q, Cheng T. Insect Biochem Mol Biol. 2017 upregulated in the MSG. qRT-PCR,RNA-seq middle silk gland (MSG) and posterior silk gland (PSG) bmo_circ_0003383 circRNA bombyx mori bmo_circ_0003383 silk gland 28918159 Identification of circular RNA in the Bombyx mori silk gland. Gan H, Feng T, Wu Y, Liu C, Xia Q, Cheng T. Insect Biochem Mol Biol. 2017 upregulated in the MSG. qRT-PCR,RNA-seq middle silk gland (MSG) and posterior silk gland (PSG) bmo_circ_0003518 circRNA bombyx mori bmo_circ_0003518 silk gland 28918159 Identification of circular RNA in the Bombyx mori silk gland. Gan H, Feng T, Wu Y, Liu C, Xia Q, Cheng T. Insect Biochem Mol Biol. 2017 We further experimentally validated the candidate B. mori circRNAs. Convergent and divergent primers were designed to amplify each circRNA in the RNase R-treated sample (cDNA) and genomic DNA. Convergent primers were designed as a positive control for the corresponding linear transcripts, and divergent primers were designed to detect the circular template. Theoretically, convergent primers should amplify products from both the cDNA and genomic DNA, whereas the divergent primers would only amplify circRNA from cDNA and would fail to amplify a product from the genomic DNA. The reverse transcription PCR amplification results showed that 16 of 38 randomly chosen circRNA were validated successfully. RT-PCR, RNA-seq middle silk gland (MSG) and posterior silk gland (PSG) bmo_circ_0003542 circRNA bombyx mori bmo_circ_0003542 silk gland 28918159 Identification of circular RNA in the Bombyx mori silk gland. Gan H, Feng T, Wu Y, Liu C, Xia Q, Cheng T. Insect Biochem Mol Biol. 2017 We further experimentally validated the candidate B. mori circRNAs. Convergent and divergent primers were designed to amplify each circRNA in the RNase R-treated sample (cDNA) and genomic DNA. Convergent primers were designed as a positive control for the corresponding linear transcripts, and divergent primers were designed to detect the circular template. Theoretically, convergent primers should amplify products from both the cDNA and genomic DNA, whereas the divergent primers would only amplify circRNA from cDNA and would fail to amplify a product from the genomic DNA. The reverse transcription PCR amplification results showed that 16 of 38 randomly chosen circRNA were validated successfully. RT-PCR, RNA-seq middle silk gland (MSG) and posterior silk gland (PSG) circRNA_0827 circRNA bombyx mori cytoplasmic polyhedrosis virus infection 29268657 Identification and characterization of circular RNAs in the silkworm midgut following Bombyx mori cytoplasmic polyhedrosis virus infection. Hu X, Zhu M, Zhang X, Liu B, Liang Z, Huang L, Xu J, Yu L, Li K, Zar MS, Xue R, Cao G, Gong C. RNA Biol. 2018 According to the sequencing results, 6 circRNAs were selected randomly for validation with divergent primers. Distinct products of the expected size were amplified using the divergent primers and confirmed by Sanger sequencing. The results showed that the selected 6 circRNAs in the silkworm midgut had covalently closed, continuous loop structures with neither 5 to 3 polarity nor a polyadenylated tail, which is consistent with predictions. qRT-PCR, RNA-seq silkworm midgut circRNA_0962 circRNA bombyx mori cytoplasmic polyhedrosis virus infection 29268657 Identification and characterization of circular RNAs in the silkworm midgut following Bombyx mori cytoplasmic polyhedrosis virus infection. Hu X, Zhu M, Zhang X, Liu B, Liang Z, Huang L, Xu J, Yu L, Li K, Zar MS, Xue R, Cao G, Gong C. RNA Biol. 2018 According to the sequencing results, 6 circRNAs were selected randomly for validation with divergent primers. Distinct products of the expected size were amplified using the divergent primers and confirmed by Sanger sequencing. The results showed that the selected 6 circRNAs in the silkworm midgut had covalently closed, continuous loop structures with neither 5 to 3 polarity nor a polyadenylated tail, which is consistent with predictions. The expression level was induced by BmCPV infection. The expression tendency was consistent with the CircSeq results. qRT-PCR, RNA-seq silkworm midgut circRNA_1193 circRNA bombyx mori cytoplasmic polyhedrosis virus infection 29268657 Identification and characterization of circular RNAs in the silkworm midgut following Bombyx mori cytoplasmic polyhedrosis virus infection. Hu X, Zhu M, Zhang X, Liu B, Liang Z, Huang L, Xu J, Yu L, Li K, Zar MS, Xue R, Cao G, Gong C. RNA Biol. 2018 According to the sequencing results, 6 circRNAs were selected randomly for validation with divergent primers. Distinct products of the expected size were amplified using the divergent primers and confirmed by Sanger sequencing. The results showed that the selected 6 circRNAs in the silkworm midgut had covalently closed, continuous loop structures with neither 5 to 3 polarity nor a polyadenylated tail, which is consistent with predictions. The expression level was induced by BmCPV infection. The expression tendency was consistent with the CircSeq results. qRT-PCR, RNA-seq silkworm midgut circRNA_5655 circRNA bombyx mori cytoplasmic polyhedrosis virus infection 29268657 Identification and characterization of circular RNAs in the silkworm midgut following Bombyx mori cytoplasmic polyhedrosis virus infection. Hu X, Zhu M, Zhang X, Liu B, Liang Z, Huang L, Xu J, Yu L, Li K, Zar MS, Xue R, Cao G, Gong C. RNA Biol. 2018 According to the sequencing results, 6 circRNAs were selected randomly for validation with divergent primers. Distinct products of the expected size were amplified using the divergent primers and confirmed by Sanger sequencing. The results showed that the selected 6 circRNAs in the silkworm midgut had covalently closed, continuous loop structures with neither 5 to 3 polarity nor a polyadenylated tail, which is consistent with predictions. The expression level was induced by BmCPV infection. The expression tendency was consistent with the CircSeq results. qRT-PCR, RNA-seq silkworm midgut circRNA_6031 circRNA bombyx mori cytoplasmic polyhedrosis virus infection 29268657 Identification and characterization of circular RNAs in the silkworm midgut following Bombyx mori cytoplasmic polyhedrosis virus infection. Hu X, Zhu M, Zhang X, Liu B, Liang Z, Huang L, Xu J, Yu L, Li K, Zar MS, Xue R, Cao G, Gong C. RNA Biol. 2018 According to the sequencing results, 6 circRNAs were selected randomly for validation with divergent primers. Distinct products of the expected size were amplified using the divergent primers and confirmed by Sanger sequencing. The results showed that the selected 6 circRNAs in the silkworm midgut had covalently closed, continuous loop structures with neither 5 to 3 polarity nor a polyadenylated tail, which is consistent with predictions. The expression level was induced by BmCPV infection. The expression tendency was consistent with the CircSeq results. qRT-PCR, RNA-seq silkworm midgut circRNA_2439 circRNA bombyx mori cytoplasmic polyhedrosis virus infection 29268657 Identification and characterization of circular RNAs in the silkworm midgut following Bombyx mori cytoplasmic polyhedrosis virus infection. Hu X, Zhu M, Zhang X, Liu B, Liang Z, Huang L, Xu J, Yu L, Li K, Zar MS, Xue R, Cao G, Gong C. RNA Biol. 2018 The expression level was induced by BmCPV infection. The expression tendency was consistent with the CircSeq results. qRT-PCR, RNA-seq silkworm midgut cel_circ_0000038 circRNA caenorhabditis elegans afd-1 cel_circ_0000038,cel_circ_008208 aging 29298683 Global accumulation of circRNAs during aging in Caenorhabditis elegans. Cortés-López M, Gruner MR, Cooper DA, Gruner HN, Voda AI, van der Linden AM, Miura P. BMC Genomics. 2018 The presence of a back-spliced junction was confirmed by Sanger sequencing of RT-PCR products. Enriched upon RNase R treatment. We set out to confirm two of these high abundance circRNAs using Northern blot analysis: cel_circ_0000038 and cel_circ_0000439. Significantly upregulated in D-10 versus L4. qRT-PCR,sanger sequencing, northern blots the C. elegans Bristol N2 wild type strain, L4 larval stage, D-1, D-7 and D-10 of adulthood. cel_circ_0000040 circRNA caenorhabditis elegans abtm-1 cel_circ_0000040,cel_circ_000150 aging 29298683 Global accumulation of circRNAs during aging in Caenorhabditis elegans. Cortés-López M, Gruner MR, Cooper DA, Gruner HN, Voda AI, van der Linden AM, Miura P. BMC Genomics. 2018 The presence of a back-spliced junction was confirmed by Sanger sequencing of RT-PCR products. Significantly upregulated in D-10 versus L4. qRT-PCR,sanger sequencing the C. elegans Bristol N2 wild type strain, L4 larval stage, D-1, D-7 and D-10 of adulthood. cel_circ_0000075 circRNA caenorhabditis elegans gld-2 cel_circ_0000075,cel_circ_008564 aging 29298683 Global accumulation of circRNAs during aging in Caenorhabditis elegans. Cortés-López M, Gruner MR, Cooper DA, Gruner HN, Voda AI, van der Linden AM, Miura P. BMC Genomics. 2018 The presence of a back-spliced junction was confirmed by Sanger sequencing of RT-PCR products. Significantly upregulated in D-10 versus L4. qRT-PCR,sanger sequencing the C. elegans Bristol N2 wild type strain, L4 larval stage, D-1, D-7 and D-10 of adulthood. cel_circ_0000105 circRNA caenorhabditis elegans daf-16 cel_circ_0000105,cel_circ_008567 aging 29298683 Global accumulation of circRNAs during aging in Caenorhabditis elegans. Cortés-López M, Gruner MR, Cooper DA, Gruner HN, Voda AI, van der Linden AM, Miura P. BMC Genomics. 2018 The presence of a back-spliced junction was confirmed by Sanger sequencing of RT-PCR products. Enriched upon RNase R treatment. qRT-PCR,sanger sequencing the C. elegans Bristol N2 wild type strain, L4 larval stage, D-1, D-7 and D-10 of adulthood. circzip-2 circRNA caenorhabditis elegans zip-2 cel_circ_0000308,cel_circ_000006 Parkinson¡¯s disease 29363043 Functional Characterization of Novel Circular RNA Molecule, circzip-2 and Its Synthesizing Gene zip-2 in C. elegans Model of Parkinsons Disease. Kumar L, Shamsuzzama, Jadiya P, Haque R, Shukla S, Nazir A. Mol Neurobiol. 2018 In order to quantify the level of circRNAs circzip-2 and cel_circ_000005 in PD model of C. elegans,we carried out quantitative real-time PCR wherein we observed the downregulation of circzip-2, the expression level of circzip-2 was significantly downregulated by 17.90-fold (p < 0.001) in PD model as compared to wild-type strain of C. elegans. qRT-PCR PD model and wild-type strain of C. elegans miR-60-3p circRNA-miRNA predicted circzip-2 possibly sponges microRNA molecule miR-60 towards asserting an important role in various processes associated with PD. cel_circ_0000308 circRNA caenorhabditis elegans zip-2 cel_circ_0000308,cel_circ_000006 aging 29298683 Global accumulation of circRNAs during aging in Caenorhabditis elegans. Cortés-López M, Gruner MR, Cooper DA, Gruner HN, Voda AI, van der Linden AM, Miura P. BMC Genomics. 2018 The presence of a back-spliced junction was confirmed by Sanger sequencing of RT-PCR products. Enriched upon RNase R treatment. Significantly upregulated in D-10 versus L4. qRT-PCR,sanger sequencing the C. elegans Bristol N2 wild type strain, L4 larval stage, D-1, D-7 and D-10 of adulthood. cel_circ_0000438 circRNA caenorhabditis elegans crh-1 cel_circ_0000438,cel_circ_000018 aging 29298683 Global accumulation of circRNAs during aging in Caenorhabditis elegans. Cortés-López M, Gruner MR, Cooper DA, Gruner HN, Voda AI, van der Linden AM, Miura P. BMC Genomics. 2018 The presence of a back-spliced junction was confirmed by Sanger sequencing of RT-PCR products. Enriched upon RNase R treatment. Significantly upregulated in D-10 versus L4. qRT-PCR,sanger sequencing the C. elegans Bristol N2 wild type strain, L4 larval stage, D-1, D-7 and D-10 of adulthood. cel_circ_0000439 circRNA caenorhabditis elegans crh-1 cel_circ_0000439,cel_circ_005708 aging 29298683 Global accumulation of circRNAs during aging in Caenorhabditis elegans. Cortés-López M, Gruner MR, Cooper DA, Gruner HN, Voda AI, van der Linden AM, Miura P. BMC Genomics. 2018 The presence of a back-spliced junction was confirmed by Sanger sequencing of RT-PCR products. We set out to confirm two of these high abundance circRNAs using Northern blot analysis: cel_circ_0000038 and cel_circ_0000439. Significantly upregulated in D-10 versus L4. qRT-PCR,sanger sequencing, northern blots the C. elegans Bristol N2 wild type strain, L4 larval stage, D-1, D-7 and D-10 of adulthood. cel_circ_0001456 circRNA caenorhabditis elegans daf-2 cel_circ_0001456,cel_circ_008464 aging 29298683 Global accumulation of circRNAs during aging in Caenorhabditis elegans. Cortés-López M, Gruner MR, Cooper DA, Gruner HN, Voda AI, van der Linden AM, Miura P. BMC Genomics. 2018 The presence of a back-spliced junction was confirmed by Sanger sequencing of RT-PCR products. Significantly upregulated in D-10 versus L4. qRT-PCR,sanger sequencing the C. elegans Bristol N2 wild type strain, L4 larval stage, D-1, D-7 and D-10 of adulthood. cel_circ_new_0005000 circRNA caenorhabditis elegans skn-1 aging 29298683 Global accumulation of circRNAs during aging in Caenorhabditis elegans. Cortés-López M, Gruner MR, Cooper DA, Gruner HN, Voda AI, van der Linden AM, Miura P. BMC Genomics. 2018 The presence of a back-spliced junction was confirmed by Sanger sequencing of RT-PCR products qRT-PCR,sanger sequencing the C. elegans Bristol N2 wild type strain, L4 larval stage, D-1, D-7 and D-10 of adulthood. cel_circ_new_0005550 circRNA caenorhabditis elegans akt-1 aging 29298683 Global accumulation of circRNAs during aging in Caenorhabditis elegans. Cortés-López M, Gruner MR, Cooper DA, Gruner HN, Voda AI, van der Linden AM, Miura P. BMC Genomics. 2018 The presence of a back-spliced junction was confirmed by Sanger sequencing of RT-PCR products qRT-PCR,sanger sequencing the C. elegans Bristol N2 wild type strain, L4 larval stage, D-1, D-7 and D-10 of adulthood. cel_circ_new_0005551 circRNA caenorhabditis elegans akt-1 aging 29298683 Global accumulation of circRNAs during aging in Caenorhabditis elegans. Cortés-López M, Gruner MR, Cooper DA, Gruner HN, Voda AI, van der Linden AM, Miura P. BMC Genomics. 2018 The presence of a back-spliced junction was confirmed by Sanger sequencing of RT-PCR products. Significantly upregulated in D-10 versus L4. qRT-PCR,sanger sequencing the C. elegans Bristol N2 wild type strain, L4 larval stage, D-1, D-7 and D-10 of adulthood. cel-circRNA10 circRNA caenorhabditis elegans 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency. Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, Loewer A, Ziebold U, Landthaler M, Kocks C, le Noble F, Rajewsky N. Nature. 2013 The circRNA was validated experimentally. qRT-PCR, sanger sequencing worm cel-circRNA14 circRNA caenorhabditis elegans 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency. Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, Loewer A, Ziebold U, Landthaler M, Kocks C, le Noble F, Rajewsky N. Nature. 2013 The circRNA was validated experimentally. qRT-PCR, sanger sequencing worm cel-circRNA16 circRNA caenorhabditis elegans 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency. Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, Loewer A, Ziebold U, Landthaler M, Kocks C, le Noble F, Rajewsky N. Nature. 2013 The circRNA was validated experimentally. qRT-PCR, sanger sequencing worm cel-circRNA17 circRNA caenorhabditis elegans 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency. Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, Loewer A, Ziebold U, Landthaler M, Kocks C, le Noble F, Rajewsky N. Nature. 2013 The circRNA was validated experimentally. qRT-PCR, sanger sequencing worm cel-circRNA18 circRNA caenorhabditis elegans 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency. Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, Loewer A, Ziebold U, Landthaler M, Kocks C, le Noble F, Rajewsky N. Nature. 2013 The circRNA was validated experimentally. qRT-PCR, sanger sequencing worm cel-circRNA19 circRNA caenorhabditis elegans 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency. Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, Loewer A, Ziebold U, Landthaler M, Kocks C, le Noble F, Rajewsky N. Nature. 2013 The circRNA was validated experimentally. qRT-PCR, sanger sequencing worm cel-circRNA20 circRNA caenorhabditis elegans 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency. Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, Loewer A, Ziebold U, Landthaler M, Kocks C, le Noble F, Rajewsky N. Nature. 2013 The circRNA was validated experimentally. qRT-PCR, sanger sequencing worm cel-circRNA21 circRNA caenorhabditis elegans 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency. Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, Loewer A, Ziebold U, Landthaler M, Kocks C, le Noble F, Rajewsky N. Nature. 2013 The circRNA was validated experimentally. qRT-PCR, sanger sequencing worm cel-circRNA3 circRNA caenorhabditis elegans 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency. Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, Loewer A, Ziebold U, Landthaler M, Kocks C, le Noble F, Rajewsky N. Nature. 2013 The circRNA was validated experimentally. qRT-PCR, sanger sequencing worm cel-circRNA4 circRNA caenorhabditis elegans 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency. Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, Loewer A, Ziebold U, Landthaler M, Kocks C, le Noble F, Rajewsky N. Nature. 2013 The circRNA was validated experimentally. qRT-PCR, sanger sequencing worm cel-circRNA5 circRNA caenorhabditis elegans 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency. Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, Loewer A, Ziebold U, Landthaler M, Kocks C, le Noble F, Rajewsky N. Nature. 2013 The circRNA was validated experimentally. qRT-PCR, sanger sequencing worm cel-circRNA6 circRNA caenorhabditis elegans 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency. Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, Loewer A, Ziebold U, Landthaler M, Kocks C, le Noble F, Rajewsky N. Nature. 2013 The circRNA was validated experimentally. qRT-PCR, sanger sequencing worm cel-circRNA7 circRNA caenorhabditis elegans 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency. Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, Loewer A, Ziebold U, Landthaler M, Kocks C, le Noble F, Rajewsky N. Nature. 2013 The circRNA was validated experimentally. qRT-PCR, sanger sequencing worm cel-circRNA8 circRNA caenorhabditis elegans 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency. Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, Loewer A, Ziebold U, Landthaler M, Kocks C, le Noble F, Rajewsky N. Nature. 2013 The circRNA was validated experimentally. qRT-PCR, sanger sequencing worm cel-circRNA9 circRNA caenorhabditis elegans 23446348 Circular RNAs are a large class of animal RNAs with regulatory potency. Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, Loewer A, Ziebold U, Landthaler M, Kocks C, le Noble F, Rajewsky N. Nature. 2013 The circRNA was validated experimentally. qRT-PCR, sanger sequencing worm circLMO7 circRNA bos taurus LMO7 circRNA42 skeletal muscle development 29072698 Circular RNA profiling reveals an abundant circLMO7 that regulates myoblasts differentiation and survival by sponging miR-378a-3p. Wei X, Li H, Yang J, Hao D, Dong D, Huang Y, Lan X, Plath M, Lei C, Lin F, Bai Y, Chen H. Cell Death Dis. 2017 Our qPCR analysis found the presumed patterns of down-regulation o6f the circRNA to be remarably similar in both types of analysis, suggesting that circRNA-Seq data provided reliable information about the relative abundance of circRNAs. RNA-seq, qRT-PCR bovine muscle tissue Overexpression of circLMO7 inhibited the differentiation of primary bovine myoblasts, and it appears to function as a competing endogenous RNA for miR-378a-3p, whose involvement in bovine muscle development has been characterized beforehand. Congruent with our interpretation, circLMO7 increased the number of myoblasts in the S-phase of the cell cycle and decreased the proportion of cells in the G0/G1 phase. Moreover, it promoted the proliferation of myoblasts and protected them from apoptosis. gain of function bovine primary myoblasts miR-378a-3p circRNA-miRNA bovine primary myoblasts luciferase report assay Our analysis of potential miRNA recognition sequences revealed the presence of a putative binding site of miR-378a-3p in circLMO7. In support of this finding, overexpression of circLMO7 significantly decreased the abundance of miR-378a-3p (P<0.05). Moreover, our luciferase based assay found miR-378a-3p to inhibit Rluc expression from psiCHECK2-circLMO7W vectors. HDAC4 circFUT10 circRNA bos taurus FUT10 skeletal muscle development 29044517 CircFUT10 reduces proliferation and facilitates differentiation of myoblasts by sponging miR-133a. Li H, Yang J, Wei X, Song C, Dong D, Huang Y, Lan X, Plath M, Lei C, Ma Y, Qi X, Bai Y, Chen H. J Cell Physiol. 2018 The tissue expression assay showed that the expression of circFUT10 was high in longissimus muscle, and to be much higher (7.43-fold) at the embryonic stage compared with the adult stage, suggesting a potential role in muscle development.We found that circFUT10 was expressed predominantly in muscle and weakly expressed in other tissues. RNA-seq, qRT-PCR longissimus muscle circFUT10 induced bovine primary myoblasts differentiation and increased the expression of MyoD, MyoG, and MyhC in mRNA and protein levels. circFUT10 increased the number of myoblasts in the G0/G1 phase of the cell cycle, and decreased the proportion of cells in the S-phase. circFUT10 inhibited the proliferation of myoblasts and promoted them apoptosis. gain of function bovine primary myoblasts miR-133a circRNA-miRNA bovine primary myoblasts luciferase report assay circFUT10, by binding miR-133a, acts as a decoy to relieve miRNA inhibiting effect on SRF. SRF circRNA262 circRNA bos taurus skeletal muscle development 29072698 Circular RNA profiling reveals an abundant circLMO7 that regulates myoblasts differentiation and survival by sponging miR-378a-3p. Wei X, Li H, Yang J, Hao D, Dong D, Huang Y, Lan X, Plath M, Lei C, Lin F, Bai Y, Chen H. Cell Death Dis. 2017 Our qPCR analysis found the presumed patterns of down-regulation o6f the circRNA to be remarably similar in both types of analysis, suggesting that circRNA-Seq data provided reliable information about the relative abundance of circRNAs. RNA-seq, qRT-PCR bovine muscle tissue circRNA347 circRNA bos taurus skeletal muscle development 29072698 Circular RNA profiling reveals an abundant circLMO7 that regulates myoblasts differentiation and survival by sponging miR-378a-3p. Wei X, Li H, Yang J, Hao D, Dong D, Huang Y, Lan X, Plath M, Lei C, Lin F, Bai Y, Chen H. Cell Death Dis. 2017 Our qPCR analysis found the presumed patterns of down-regulation o6f the circRNA to be remarably similar in both types of analysis, suggesting that circRNA-Seq data provided reliable information about the relative abundance of circRNAs. RNA-seq, qRT-PCR bovine muscle tissue circRNA1039 circRNA bos taurus skeletal muscle development 29072698 Circular RNA profiling reveals an abundant circLMO7 that regulates myoblasts differentiation and survival by sponging miR-378a-3p. Wei X, Li H, Yang J, Hao D, Dong D, Huang Y, Lan X, Plath M, Lei C, Lin F, Bai Y, Chen H. Cell Death Dis. 2017 Our qPCR analysis found the presumed patterns of up-regulation o6f the circRNA to be remarably similar in both types of analysis, suggesting that circRNA-Seq data provided reliable information about the relative abundance of circRNAs. RNA-seq, qRT-PCR bovine muscle tissue circRNA1169 circRNA bos taurus skeletal muscle development 29072698 Circular RNA profiling reveals an abundant circLMO7 that regulates myoblasts differentiation and survival by sponging miR-378a-3p. Wei X, Li H, Yang J, Hao D, Dong D, Huang Y, Lan X, Plath M, Lei C, Lin F, Bai Y, Chen H. Cell Death Dis. 2017 Our qPCR analysis found the presumed patterns of up-regulation o6f the circRNA to be remarably similar in both types of analysis, suggesting that circRNA-Seq data provided reliable information about the relative abundance of circRNAs. RNA-seq, qRT-PCR bovine muscle tissue circRNA1170 circRNA bos taurus skeletal muscle development 29072698 Circular RNA profiling reveals an abundant circLMO7 that regulates myoblasts differentiation and survival by sponging miR-378a-3p. Wei X, Li H, Yang J, Hao D, Dong D, Huang Y, Lan X, Plath M, Lei C, Lin F, Bai Y, Chen H. Cell Death Dis. 2017 Our qPCR analysis found the presumed patterns of up-regulation o6f the circRNA to be remarably similar in both types of analysis, suggesting that circRNA-Seq data provided reliable information about the relative abundance of circRNAs. RNA-seq, qRT-PCR bovine muscle tissue circRNA1221 circRNA bos taurus skeletal muscle development 29072698 Circular RNA profiling reveals an abundant circLMO7 that regulates myoblasts differentiation and survival by sponging miR-378a-3p. Wei X, Li H, Yang J, Hao D, Dong D, Huang Y, Lan X, Plath M, Lei C, Lin F, Bai Y, Chen H. Cell Death Dis. 2017 Our qPCR analysis found the presumed patterns of up-regulation o6f the circRNA to be remarably similar in both types of analysis, suggesting that circRNA-Seq data provided reliable information about the relative abundance of circRNAs. RNA-seq, qRT-PCR bovine muscle tissue circRNA124 circRNA bos taurus skeletal muscle development 29072698 Circular RNA profiling reveals an abundant circLMO7 that regulates myoblasts differentiation and survival by sponging miR-378a-3p. Wei X, Li H, Yang J, Hao D, Dong D, Huang Y, Lan X, Plath M, Lei C, Lin F, Bai Y, Chen H. Cell Death Dis. 2017 Our qPCR analysis found the presumed patterns of up-regulation o6f the circRNA to be remarably similar in both types of analysis, suggesting that circRNA-Seq data provided reliable information about the relative abundance of circRNAs. RNA-seq, qRT-PCR bovine muscle tissue circRNA152 circRNA bos taurus skeletal muscle development 29072698 Circular RNA profiling reveals an abundant circLMO7 that regulates myoblasts differentiation and survival by sponging miR-378a-3p. Wei X, Li H, Yang J, Hao D, Dong D, Huang Y, Lan X, Plath M, Lei C, Lin F, Bai Y, Chen H. Cell Death Dis. 2017 Our qPCR analysis found the presumed patterns of up-regulation o6f the circRNA to be remarably similar in both types of analysis, suggesting that circRNA-Seq data provided reliable information about the relative abundance of circRNAs. RNA-seq, qRT-PCR bovine muscle tissue circRNA1945 circRNA bos taurus skeletal muscle development 29072698 Circular RNA profiling reveals an abundant circLMO7 that regulates myoblasts differentiation and survival by sponging miR-378a-3p. Wei X, Li H, Yang J, Hao D, Dong D, Huang Y, Lan X, Plath M, Lei C, Lin F, Bai Y, Chen H. Cell Death Dis. 2017 Our qPCR analysis found the presumed patterns of up-regulation o6f the circRNA to be remarably similar in both types of analysis, suggesting that circRNA-Seq data provided reliable information about the relative abundance of circRNAs. RNA-seq, qRT-PCR bovine muscle tissue circRNA1946 circRNA bos taurus skeletal muscle development 29072698 Circular RNA profiling reveals an abundant circLMO7 that regulates myoblasts differentiation and survival by sponging miR-378a-3p. Wei X, Li H, Yang J, Hao D, Dong D, Huang Y, Lan X, Plath M, Lei C, Lin F, Bai Y, Chen H. Cell Death Dis. 2017 Our qPCR analysis found the presumed patterns of up-regulation o6f the circRNA to be remarably similar in both types of analysis, suggesting that circRNA-Seq data provided reliable information about the relative abundance of circRNAs. RNA-seq, qRT-PCR bovine muscle tissue circRNA1947 circRNA bos taurus skeletal muscle development 29072698 Circular RNA profiling reveals an abundant circLMO7 that regulates myoblasts differentiation and survival by sponging miR-378a-3p. Wei X, Li H, Yang J, Hao D, Dong D, Huang Y, Lan X, Plath M, Lei C, Lin F, Bai Y, Chen H. Cell Death Dis. 2017 Our qPCR analysis found the presumed patterns of up-regulation o6f the circRNA to be remarably similar in both types of analysis, suggesting that circRNA-Seq data provided reliable information about the relative abundance of circRNAs. RNA-seq, qRT-PCR bovine muscle tissue circRNA294 circRNA bos taurus skeletal muscle development 29072698 Circular RNA profiling reveals an abundant circLMO7 that regulates myoblasts differentiation and survival by sponging miR-378a-3p. Wei X, Li H, Yang J, Hao D, Dong D, Huang Y, Lan X, Plath M, Lei C, Lin F, Bai Y, Chen H. Cell Death Dis. 2017 Our qPCR analysis found the presumed patterns of up-regulation o6f the circRNA to be remarably similar in both types of analysis, suggesting that circRNA-Seq data provided reliable information about the relative abundance of circRNAs. RNA-seq, qRT-PCR bovine muscle tissue circRNA297 circRNA bos taurus skeletal muscle development 29072698 Circular RNA profiling reveals an abundant circLMO7 that regulates myoblasts differentiation and survival by sponging miR-378a-3p. Wei X, Li H, Yang J, Hao D, Dong D, Huang Y, Lan X, Plath M, Lei C, Lin F, Bai Y, Chen H. Cell Death Dis. 2017 Our qPCR analysis found the presumed patterns of up-regulation o6f the circRNA to be remarably similar in both types of analysis, suggesting that circRNA-Seq data provided reliable information about the relative abundance of circRNAs. RNA-seq, qRT-PCR bovine muscle tissue circRNA378 circRNA bos taurus skeletal muscle development 29072698 Circular RNA profiling reveals an abundant circLMO7 that regulates myoblasts differentiation and survival by sponging miR-378a-3p. Wei X, Li H, Yang J, Hao D, Dong D, Huang Y, Lan X, Plath M, Lei C, Lin F, Bai Y, Chen H. Cell Death Dis. 2017 Our qPCR analysis found the presumed patterns of up-regulation o6f the circRNA to be remarably similar in both types of analysis, suggesting that circRNA-Seq data provided reliable information about the relative abundance of circRNAs. RNA-seq, qRT-PCR bovine muscle tissue circRNA379 circRNA bos taurus skeletal muscle development 29072698 Circular RNA profiling reveals an abundant circLMO7 that regulates myoblasts differentiation and survival by sponging miR-378a-3p. Wei X, Li H, Yang J, Hao D, Dong D, Huang Y, Lan X, Plath M, Lei C, Lin F, Bai Y, Chen H. Cell Death Dis. 2017 Our qPCR analysis found the presumed patterns of up-regulation o6f the circRNA to be remarably similar in both types of analysis, suggesting that circRNA-Seq data provided reliable information about the relative abundance of circRNAs. RNA-seq, qRT-PCR bovine muscle tissue circRNA46 circRNA bos taurus skeletal muscle development 29072698 Circular RNA profiling reveals an abundant circLMO7 that regulates myoblasts differentiation and survival by sponging miR-378a-3p. Wei X, Li H, Yang J, Hao D, Dong D, Huang Y, Lan X, Plath M, Lei C, Lin F, Bai Y, Chen H. Cell Death Dis. 2017 Our qPCR analysis found the presumed patterns of up-regulation o6f the circRNA to be remarably similar in both types of analysis, suggesting that circRNA-Seq data provided reliable information about the relative abundance of circRNAs. RNA-seq, qRT-PCR bovine muscle tissue cCsn1s1(1) circRNA bos taurus Csn1s1 lactation 27040791 Circular RNA of cattle casein genes are highly expressed in bovine mammary gland. Zhang C, Wu H, Wang Y, Zhu S, Liu J, Fang X, Chen H. J Dairy Sci. 2016 expressed at significantly higher levels on lactation d 90 than on lactation d 250. RNA-seq, qRT-PCR the bovine mammary gland cCsn1s1(2) circRNA bos taurus Csn1s1 lactation 27040791 Circular RNA of cattle casein genes are highly expressed in bovine mammary gland. Zhang C, Wu H, Wang Y, Zhu S, Liu J, Fang X, Chen H. J Dairy Sci. 2016 expressed at significantly higher levels on lactation d 90 than on lactation d 250. RNA-seq, qRT-PCR the bovine mammary gland cCsn1s1(3) circRNA bos taurus Csn1s1 lactation 27040791 Circular RNA of cattle casein genes are highly expressed in bovine mammary gland. Zhang C, Wu H, Wang Y, Zhu S, Liu J, Fang X, Chen H. J Dairy Sci. 2016 expressed at significantly higher levels on lactation d 90 than on lactation d 250. RNA-seq, qRT-PCR the bovine mammary gland cCsn1s2 circRNA bos taurus Csn1s2 lactation 27040791 Circular RNA of cattle casein genes are highly expressed in bovine mammary gland. Zhang C, Wu H, Wang Y, Zhu S, Liu J, Fang X, Chen H. J Dairy Sci. 2016 expressed at significantly higher levels on lactation d 90 than on lactation d 250. RNA-seq, qRT-PCR the bovine mammary gland cCsn2 circRNA bos taurus Csn2 lactation 27040791 Circular RNA of cattle casein genes are highly expressed in bovine mammary gland. Zhang C, Wu H, Wang Y, Zhu S, Liu J, Fang X, Chen H. J Dairy Sci. 2016 expressed at significantly higher levels on lactation d 90 than on lactation d 250. RNA-seq, qRT-PCR the bovine mammary gland circ_000207 circRNA danio rerio 27878987 Identification and characterization of circular RNAs in zebrafish. Shen Y, Guo X, Wang W. FEBS Lett. 2017 This circRNA was comfirmed experimentally. qRT-PCR zebrafish brain,eyes, heart, liver, spleen, kidney, intestines, skin, muscle, gill,ovary and testis circ_000348 circRNA danio rerio 27878987 Identification and characterization of circular RNAs in zebrafish. Shen Y, Guo X, Wang W. FEBS Lett. 2017 This circRNA was comfirmed experimentally. qRT-PCR zebrafish brain,eyes, heart, liver, spleen, kidney, intestines, skin, muscle, gill,ovary and testis circ_000425 circRNA danio rerio 27878987 Identification and characterization of circular RNAs in zebrafish. Shen Y, Guo X, Wang W. FEBS Lett. 2017 This circRNA was comfirmed experimentally. qRT-PCR zebrafish brain,eyes, heart, liver, spleen, kidney, intestines, skin, muscle, gill,ovary and testis circ_000986 circRNA danio rerio 27878987 Identification and characterization of circular RNAs in zebrafish. Shen Y, Guo X, Wang W. FEBS Lett. 2017 This circRNA was comfirmed experimentally. qRT-PCR zebrafish brain,eyes, heart, liver, spleen, kidney, intestines, skin, muscle, gill,ovary and testis circ_001175 circRNA danio rerio 27878987 Identification and characterization of circular RNAs in zebrafish. Shen Y, Guo X, Wang W. FEBS Lett. 2017 This circRNA was comfirmed experimentally. qRT-PCR zebrafish brain,eyes, heart, liver, spleen, kidney, intestines, skin, muscle, gill,ovary and testis circ_002177 circRNA danio rerio 27878987 Identification and characterization of circular RNAs in zebrafish. Shen Y, Guo X, Wang W. FEBS Lett. 2017 This circRNA was comfirmed experimentally. qRT-PCR zebrafish brain,eyes, heart, liver, spleen, kidney, intestines, skin, muscle, gill,ovary and testis circ_002941 circRNA danio rerio 27878987 Identification and characterization of circular RNAs in zebrafish. Shen Y, Guo X, Wang W. FEBS Lett. 2017 This circRNA was comfirmed experimentally. qRT-PCR zebrafish brain,eyes, heart, liver, spleen, kidney, intestines, skin, muscle, gill,ovary and testis circ_002971 circRNA danio rerio 27878987 Identification and characterization of circular RNAs in zebrafish. Shen Y, Guo X, Wang W. FEBS Lett. 2017 This circRNA was comfirmed experimentally. qRT-PCR zebrafish brain,eyes, heart, liver, spleen, kidney, intestines, skin, muscle, gill,ovary and testis circ_003193 circRNA danio rerio 27878987 Identification and characterization of circular RNAs in zebrafish. Shen Y, Guo X, Wang W. FEBS Lett. 2017 This circRNA was comfirmed experimentally. qRT-PCR zebrafish brain,eyes, heart, liver, spleen, kidney, intestines, skin, muscle, gill,ovary and testis circ_000067 circRNA danio rerio 27878987 Identification and characterization of circular RNAs in zebrafish. Shen Y, Guo X, Wang W. FEBS Lett. 2017 This circRNA was comfirmed experimentally. sanger sequencing zebrafish brain,eyes, heart, liver, spleen, kidney, intestines, skin, muscle, gill,ovary and testis circ_000223 circRNA danio rerio 27878987 Identification and characterization of circular RNAs in zebrafish. Shen Y, Guo X, Wang W. FEBS Lett. 2017 This circRNA was comfirmed experimentally. sanger sequencing zebrafish brain,eyes, heart, liver, spleen, kidney, intestines, skin, muscle, gill,ovary and testis circ_000789 circRNA danio rerio 27878987 Identification and characterization of circular RNAs in zebrafish. Shen Y, Guo X, Wang W. FEBS Lett. 2017 This circRNA was comfirmed experimentally. sanger sequencing zebrafish brain,eyes, heart, liver, spleen, kidney, intestines, skin, muscle, gill,ovary and testis circ_000922 circRNA danio rerio 27878987 Identification and characterization of circular RNAs in zebrafish. Shen Y, Guo X, Wang W. FEBS Lett. 2017 This circRNA was comfirmed experimentally. sanger sequencing zebrafish brain,eyes, heart, liver, spleen, kidney, intestines, skin, muscle, gill,ovary and testis circ_000948 circRNA danio rerio 27878987 Identification and characterization of circular RNAs in zebrafish. Shen Y, Guo X, Wang W. FEBS Lett. 2017 This circRNA was comfirmed experimentally. sanger sequencing zebrafish brain,eyes, heart, liver, spleen, kidney, intestines, skin, muscle, gill,ovary and testis circ_001199 circRNA danio rerio 27878987 Identification and characterization of circular RNAs in zebrafish. Shen Y, Guo X, Wang W. FEBS Lett. 2017 This circRNA was comfirmed experimentally. sanger sequencing zebrafish brain,eyes, heart, liver, spleen, kidney, intestines, skin, muscle, gill,ovary and testis circ_001501 circRNA danio rerio 27878987 Identification and characterization of circular RNAs in zebrafish. Shen Y, Guo X, Wang W. FEBS Lett. 2017 This circRNA was comfirmed experimentally. sanger sequencing zebrafish brain,eyes, heart, liver, spleen, kidney, intestines, skin, muscle, gill,ovary and testis circ_001651 circRNA danio rerio ENSDART00000153682 27878987 Identification and characterization of circular RNAs in zebrafish. Shen Y, Guo X, Wang W. FEBS Lett. 2017 This circRNA was comfirmed experimentally. sanger sequencing zebrafish brain,eyes, heart, liver, spleen, kidney, intestines, skin, muscle, gill,ovary and testis circ_001685 circRNA danio rerio 27878987 Identification and characterization of circular RNAs in zebrafish. Shen Y, Guo X, Wang W. FEBS Lett. 2017 This circRNA was comfirmed experimentally. sanger sequencing zebrafish brain,eyes, heart, liver, spleen, kidney, intestines, skin, muscle, gill,ovary and testis circ_002254 circRNA danio rerio 27878987 Identification and characterization of circular RNAs in zebrafish. Shen Y, Guo X, Wang W. FEBS Lett. 2017 This circRNA was comfirmed experimentally. sanger sequencing zebrafish brain,eyes, heart, liver, spleen, kidney, intestines, skin, muscle, gill,ovary and testis circ_002647 circRNA danio rerio 27878987 Identification and characterization of circular RNAs in zebrafish. Shen Y, Guo X, Wang W. FEBS Lett. 2017 This circRNA was comfirmed experimentally. sanger sequencing zebrafish brain,eyes, heart, liver, spleen, kidney, intestines, skin, muscle, gill,ovary and testis circ_002873 circRNA danio rerio 27878987 Identification and characterization of circular RNAs in zebrafish. Shen Y, Guo X, Wang W. FEBS Lett. 2017 This circRNA was comfirmed experimentally. sanger sequencing zebrafish brain,eyes, heart, liver, spleen, kidney, intestines, skin, muscle, gill,ovary and testis circRNA161 circRNA sus scrofa muscle 28380516 Integrated analysis of non-coding RNA and mRNA expression profiles of 2 pig breeds differing in muscle traits. Sun J, Xie M, Huang Z, Li H, Chen T, Sun R, Wang J, Xi Q, Wu T, Zhang Y. J Anim Sci. 2017 Significantly lower in lean-type pigs (Landrace, LW) compared with Chinese fat-type pigs (Lantang,LT). qRT-PCR,RNA-seq lean-type pigs (Landrace, LW) and Chinese fat-type pigs (Lantang,LT) circRNA283 circRNA sus scrofa muscle 28380516 Integrated analysis of non-coding RNA and mRNA expression profiles of 2 pig breeds differing in muscle traits. Sun J, Xie M, Huang Z, Li H, Chen T, Sun R, Wang J, Xi Q, Wu T, Zhang Y. J Anim Sci. 2017 Significantly lower in lean-type pigs (Landrace, LW) compared with Chinese fat-type pigs (Lantang,LT). qRT-PCR,RNA-seq lean-type pigs (Landrace, LW) and Chinese fat-type pigs (Lantang,LT) circRNA3803 circRNA sus scrofa muscle 28380516 Integrated analysis of non-coding RNA and mRNA expression profiles of 2 pig breeds differing in muscle traits. Sun J, Xie M, Huang Z, Li H, Chen T, Sun R, Wang J, Xi Q, Wu T, Zhang Y. J Anim Sci. 2017 Significantly lower in lean-type pigs (Landrace, LW) compared with Chinese fat-type pigs (Lantang,LT). qRT-PCR,RNA-seq lean-type pigs (Landrace, LW) and Chinese fat-type pigs (Lantang,LT) circRNA3806 circRNA sus scrofa muscle 28380516 Integrated analysis of non-coding RNA and mRNA expression profiles of 2 pig breeds differing in muscle traits. Sun J, Xie M, Huang Z, Li H, Chen T, Sun R, Wang J, Xi Q, Wu T, Zhang Y. J Anim Sci. 2017 Significantly lower in lean-type pigs (Landrace, LW) compared with Chinese fat-type pigs (Lantang,LT). qRT-PCR,RNA-seq lean-type pigs (Landrace, LW) and Chinese fat-type pigs (Lantang,LT) circRNA4918 circRNA sus scrofa muscle 28380516 Integrated analysis of non-coding RNA and mRNA expression profiles of 2 pig breeds differing in muscle traits. Sun J, Xie M, Huang Z, Li H, Chen T, Sun R, Wang J, Xi Q, Wu T, Zhang Y. J Anim Sci. 2017 Significantly lower in lean-type pigs (Landrace, LW) compared with Chinese fat-type pigs (Lantang,LT). qRT-PCR,RNA-seq lean-type pigs (Landrace, LW) and Chinese fat-type pigs (Lantang,LT) circRNA933 circRNA sus scrofa muscle 28380516 Integrated analysis of non-coding RNA and mRNA expression profiles of 2 pig breeds differing in muscle traits. Sun J, Xie M, Huang Z, Li H, Chen T, Sun R, Wang J, Xi Q, Wu T, Zhang Y. J Anim Sci. 2017 Significantly lower in lean-type pigs (Landrace, LW) compared with Chinese fat-type pigs (Lantang,LT). qRT-PCR,RNA-seq lean-type pigs (Landrace, LW) and Chinese fat-type pigs (Lantang,LT) circRNA010340 circRNA sus scrofa muscular aging 29416711 Comprehensive transcriptional landscape of porcine cardiac and skeletal muscles reveals differences of aging. Chen J, Zou Q, Lv D, Wei Y, Raza MA, Chen Y, Li P, Xi X, Xu H, Wen A, Zhu L, Tang G, Li M, Jiang A, Liu Y, Fu Y, Jiang Y, Li X. Oncotarget. 2018 Expression of several selected genes was significantly different during aging, which may be closely related to biological functions or function in a network. qRT-PCR,RNA-seq pig cardiac muscle (CM) and skeletal muscles (SM) circRNA014844 circRNA sus scrofa muscular aging 29416711 Comprehensive transcriptional landscape of porcine cardiac and skeletal muscles reveals differences of aging. Chen J, Zou Q, Lv D, Wei Y, Raza MA, Chen Y, Li P, Xi X, Xu H, Wen A, Zhu L, Tang G, Li M, Jiang A, Liu Y, Fu Y, Jiang Y, Li X. Oncotarget. 2018 Expression of several selected genes was significantly different during aging, which may be closely related to biological functions or function in a network. qRT-PCR,RNA-seq pig cardiac muscle (CM) and skeletal muscles (SM) circCSPP1 circRNA sus scrofa CSPP1 porcine embryonic brain development 26541409 Spatio-temporal regulation of circular RNA expression during porcine embryonic brain development. Venø MT, Hansen TB, Venø ST, Clausen BH, Grebing M, Finsen B, Holm IE, Kjems J. Genome Biol. 2015 Expression levels of CSPP1 circRNA, containing exons 6¨C10, were much higher than those of the linear transcript from the CSPP1 gene (3.7-fold higher circRNA expression at E60. The circular nature of CSPP1 circRNAs was confirmed by their resistance to RNase R digestion using northern blot and quantitative PCR at the time-points of highest circRNA expression, E42 and E60 in cortex. qRT-PCR,RNA-seq, northern blots porcine embryonic brain circHDAC2 circRNA sus scrofa HDAC2 porcine embryonic brain development 26541409 Spatio-temporal regulation of circular RNA expression during porcine embryonic brain development. Venø MT, Hansen TB, Venø ST, Clausen BH, Grebing M, Finsen B, Holm IE, Kjems J. Genome Biol. 2015 The circular nature of HDAC2 circRNAs was confirmed by their resistance to RNase R digestion using northern blot and quantitative PCR at the time-points of highest circRNA expression, E42 and E60 in cortex. qRT-PCR,RNA-seq, northern blots porcine embryonic brain circRIMS2 circRNA sus scrofa RIMS2 porcine embryonic brain development 26541409 Spatio-temporal regulation of circular RNA expression during porcine embryonic brain development. Venø MT, Hansen TB, Venø ST, Clausen BH, Grebing M, Finsen B, Holm IE, Kjems J. Genome Biol. 2015 The circular nature of RIMS2 circRNAs was confirmed by their resistance to RNase R digestion using northern blot and quantitative PCR at the time-points of highest circRNA expression, E42 and E60 in cortex. qRT-PCR,RNA-seq, northern blots porcine embryonic brain ssc_circ:chr10:10312706-10318322 circRNA sus scrofa 29268579 Circular RNA expression profiles in the porcine liver of two distinct phenotype pig breeds. Huang M, Shen Y, Mao H, Chen L, Chen J, Guo X, Xu N. Asian-Australas J Anim Sci. 2017 Down-regulated in JH pigs compared to LD. qRT-PCR,RNA-seq porcine livers ssc_circ:chr12:62513102-62523689 circRNA sus scrofa 29268579 Circular RNA expression profiles in the porcine liver of two distinct phenotype pig breeds. Huang M, Shen Y, Mao H, Chen L, Chen J, Guo X, Xu N. Asian-Australas J Anim Sci. 2017 Down-regulated in JH pigs compared to LD. qRT-PCR,RNA-seq porcine livers ssc_circ:chr13:210044909-210047801 circRNA sus scrofa 29268579 Circular RNA expression profiles in the porcine liver of two distinct phenotype pig breeds. Huang M, Shen Y, Mao H, Chen L, Chen J, Guo X, Xu N. Asian-Australas J Anim Sci. 2017 Down-regulated in JH pigs compared to LD. qRT-PCR,RNA-seq porcine livers ssc_circ:chr15:131201187-131208307 circRNA sus scrofa 29268579 Circular RNA expression profiles in the porcine liver of two distinct phenotype pig breeds. Huang M, Shen Y, Mao H, Chen L, Chen J, Guo X, Xu N. Asian-Australas J Anim Sci. 2017 Down-regulated in JH pigs compared to LD. qRT-PCR,RNA-seq porcine livers ssc_circ:chr4:70757387-70758582 circRNA sus scrofa 29268579 Circular RNA expression profiles in the porcine liver of two distinct phenotype pig breeds. Huang M, Shen Y, Mao H, Chen L, Chen J, Guo X, Xu N. Asian-Australas J Anim Sci. 2017 Down-regulated in JH pigs compared to LD. qRT-PCR,RNA-seq porcine livers ssc_circ:chr5:477934-479492 circRNA sus scrofa 29268579 Circular RNA expression profiles in the porcine liver of two distinct phenotype pig breeds. Huang M, Shen Y, Mao H, Chen L, Chen J, Guo X, Xu N. Asian-Australas J Anim Sci. 2017 Down-regulated in JH pigs compared to LD. qRT-PCR,RNA-seq porcine livers ssc_circ:chr5:65277754-65280239 circRNA sus scrofa 29268579 Circular RNA expression profiles in the porcine liver of two distinct phenotype pig breeds. Huang M, Shen Y, Mao H, Chen L, Chen J, Guo X, Xu N. Asian-Australas J Anim Sci. 2017 Down-regulated in JH pigs compared to LD. qRT-PCR,RNA-seq porcine livers ssc_circ:chr7:21868824-21869232 circRNA sus scrofa 29268579 Circular RNA expression profiles in the porcine liver of two distinct phenotype pig breeds. Huang M, Shen Y, Mao H, Chen L, Chen J, Guo X, Xu N. Asian-Australas J Anim Sci. 2017 Down-regulated in JH pigs compared to LD. qRT-PCR,RNA-seq porcine livers circRBFOX2.2-4 circRNA gallus gallus RBFOX2 embryonic muscle development 29036326 Circular RNAs are abundant and dynamically expressed during embryonic muscle development in chickens. Ouyang H, Chen X, Wang Z, Yu J, Jia X, Li Z, Luo W, Abdalla BA, Jebessa E, Nie Q, Zhang X. DNA Res. 2017 up-regulated in E16 VS E11 and P1 VS E11 comparison groups. RNA-seq, qRT-PCR six female chickens (E11, E16, and P1; each stage two individuals) We validated that circRBFOX2s promoted cell proliferation through interacted with miR-206. loss of function, gain of function Chicken primary myoblasts, DF-1 cells, QM-7 cells gga-miR-1a-3p and gga-miR-206 circRNA-miRNA DF-1 cells luciferase report assay These results suggested that circRBFOX2s are able to interact with miR-1a-3p and miR-206. CCND2 circRBFOX2.2-3 circRNA gallus gallus RBFOX2 embryonic muscle development 29036326 Circular RNAs are abundant and dynamically expressed during embryonic muscle development in chickens. Ouyang H, Chen X, Wang Z, Yu J, Jia X, Li Z, Luo W, Abdalla BA, Jebessa E, Nie Q, Zhang X. DNA Res. 2017 up-regulated in E16 VS E11, P1 VS E11, and P1 VS E16 comparison groups. RNA-seq, qRT-PCR six female chickens (E11, E16, and P1; each stage two individuals) We validated that circRBFOX2s promoted cell proliferation through interacted with miR-206. loss of function, gain of function Chicken primary myoblasts, DF-1 cells, QM-7 cells gga-miR-1a-3p and gga-miR-206 circRNA-miRNA DF-1 cells luciferase report assay These results suggested that circRBFOX2s are able to interact with miR-1a-3p and miR-206. CCND2 chr1:194735582-194744050- circRNA gallus gallus ALV-J-induced tumor 28415618 Circular RNA alterations are involved in resistance to avian leukosis virus subgroup-J-induced tumor formation in chickens. Zhang X, Yan Y, Lei X, Li A, Zhang H, Dai Z, Li X, Chen W, Lin W, Chen F, Ma J, Xie Q. Oncotarget. 2017 up-regulated in liver tissues from ALV-J-resistant chickens compared with ALV-J-susceptible groups. RNA-seq, qRT-PCR chicken liver tissue gga-miR-6660-3p, gga-miR-1662, gga-miR-15c-5p, gga-miR-15b-5p, gga-miR-1787 circRNA-miRNA predicted chr23:5549365-5549645- circRNA gallus gallus ALV-J-induced tumor 28415618 Circular RNA alterations are involved in resistance to avian leukosis virus subgroup-J-induced tumor formation in chickens. Zhang X, Yan Y, Lei X, Li A, Zhang H, Dai Z, Li X, Chen W, Lin W, Chen F, Ma J, Xie Q. Oncotarget. 2017 up-regulated in liver tissues from ALV-J-resistant chickens compared with ALV-J-susceptible groups. RNA-seq, qRT-PCR chicken liver tissue gga-miR-6702-5p, gga-miR-1662, gga-miR-34b-5p, gga-miR-6611-5p, gga-miR-6641-5p circRNA-miRNA predicted chr5:58225735-58230830- circRNA gallus gallus ALV-J-induced tumor 28415618 Circular RNA alterations are involved in resistance to avian leukosis virus subgroup-J-induced tumor formation in chickens. Zhang X, Yan Y, Lei X, Li A, Zhang H, Dai Z, Li X, Chen W, Lin W, Chen F, Ma J, Xie Q. Oncotarget. 2017 down-regulated in liver tissues from ALV-J-resistant chickens compared with ALV-J-susceptible groups. RNA-seq, qRT-PCR chicken liver tissue chr8:1033880-1047222- circRNA gallus gallus ALV-J-induced tumor 28415618 Circular RNA alterations are involved in resistance to avian leukosis virus subgroup-J-induced tumor formation in chickens. Zhang X, Yan Y, Lei X, Li A, Zhang H, Dai Z, Li X, Chen W, Lin W, Chen F, Ma J, Xie Q. Oncotarget. 2017 down-regulated in liver tissues from ALV-J-resistant chickens compared with ALV-J-susceptible groups. RNA-seq, qRT-PCR chicken liver tissue circFGFR2.3-6 circRNA gallus gallus FGFR2 embryonic muscle development 29036326 Circular RNAs are abundant and dynamically expressed during embryonic muscle development in chickens. Ouyang H, Chen X, Wang Z, Yu J, Jia X, Li Z, Luo W, Abdalla BA, Jebessa E, Nie Q, Zhang X. DNA Res. 2017 down-regulated in E16 VS E11 and P1 VS E11 comparison groups. RNA-seq, qRT-PCR six female chickens (E11, E16, and P1; each stage two individuals) circRBFOX2.9-11 circRNA gallus gallus RBFOX2 embryonic muscle development 29036326 Circular RNAs are abundant and dynamically expressed during embryonic muscle development in chickens. Ouyang H, Chen X, Wang Z, Yu J, Jia X, Li Z, Luo W, Abdalla BA, Jebessa E, Nie Q, Zhang X. DNA Res. 2017 up-regulated in E16 VS E11 and P1 VS E11, and down-regulated in P1 VS E16 comparison group. RNA-seq, qRT-PCR six female chickens (E11, E16, and P1; each stage two individuals) circSCRIB.28-30 circRNA gallus gallus SCRIB embryonic muscle development 29036326 Circular RNAs are abundant and dynamically expressed during embryonic muscle development in chickens. Ouyang H, Chen X, Wang Z, Yu J, Jia X, Li Z, Luo W, Abdalla BA, Jebessa E, Nie Q, Zhang X. DNA Res. 2017 up-regulated in E16 VS E11 and P1 VS E11, and down-regulated in P1 VS E16 comparison group. RNA-seq, qRT-PCR six female chickens (E11, E16, and P1; each stage two individuals) circRBFOX2.2 circRNA gallus gallus RBFOX2 embryonic muscle development 29036326 Circular RNAs are abundant and dynamically expressed during embryonic muscle development in chickens. Ouyang H, Chen X, Wang Z, Yu J, Jia X, Li Z, Luo W, Abdalla BA, Jebessa E, Nie Q, Zhang X. DNA Res. 2017 up-regulated in E16 VS E11, P1 VS E11, and P1 VS E16 comparison groups. RNA-seq, qRT-PCR six female chickens (E11, E16, and P1; each stage two individuals) circRNA AML1 circRNA saccharomyces cerevisiae AML1 24609083 Circular RNA is expressed across the eukaryotic tree of life. Wang PL, Bao Y, Yee MC, Barrett SP, Hogan GJ, Olsen MN, Dinneny JR, Brown PO, Salzman J. PLoS One. 2014 This circRNA was validated experimentally. PCR, sanger sequencing Saccharomyces cerevisiae circRNA MATA1 circRNA saccharomyces cerevisiae MATA1 24609083 Circular RNA is expressed across the eukaryotic tree of life. Wang PL, Bao Y, Yee MC, Barrett SP, Hogan GJ, Olsen MN, Dinneny JR, Brown PO, Salzman J. PLoS One. 2014 This circRNA was validated experimentally. PCR, sanger sequencing Saccharomyces cerevisiae circRNA RPL7B circRNA saccharomyces cerevisiae RPL7B 24609083 Circular RNA is expressed across the eukaryotic tree of life. Wang PL, Bao Y, Yee MC, Barrett SP, Hogan GJ, Olsen MN, Dinneny JR, Brown PO, Salzman J. PLoS One. 2014 This circRNA was validated experimentally. PCR, sanger sequencing Saccharomyces cerevisiae circRNA RPS22B circRNA saccharomyces cerevisiae RPS22B 24609083 Circular RNA is expressed across the eukaryotic tree of life. Wang PL, Bao Y, Yee MC, Barrett SP, Hogan GJ, Olsen MN, Dinneny JR, Brown PO, Salzman J. PLoS One. 2014 This circRNA was validated experimentally. PCR, sanger sequencing Saccharomyces cerevisiae circRNA SUS1 circRNA saccharomyces cerevisiae SUS1 24609083 Circular RNA is expressed across the eukaryotic tree of life. Wang PL, Bao Y, Yee MC, Barrett SP, Hogan GJ, Olsen MN, Dinneny JR, Brown PO, Salzman J. PLoS One. 2014 This circRNA was validated experimentally. PCR, sanger sequencing Saccharomyces cerevisiae circRNA TAD3 circRNA saccharomyces cerevisiae TAD3 24609083 Circular RNA is expressed across the eukaryotic tree of life. Wang PL, Bao Y, Yee MC, Barrett SP, Hogan GJ, Olsen MN, Dinneny JR, Brown PO, Salzman J. PLoS One. 2014 This circRNA was validated experimentally. PCR, sanger sequencing Saccharomyces cerevisiae circRNA YOS1 circRNA saccharomyces cerevisiae YOS1 24609083 Circular RNA is expressed across the eukaryotic tree of life. Wang PL, Bao Y, Yee MC, Barrett SP, Hogan GJ, Olsen MN, Dinneny JR, Brown PO, Salzman J. PLoS One. 2014 This circRNA was validated experimentally. PCR, sanger sequencing Saccharomyces cerevisiae circCNYPT5 circRNA saccharomyces cerevisiae CNM01190 29495353 Genome-Wide Identification of circRNAs in Pathogenic Basidiomycetous Yeast Cryptococcus neoformans Suggests Conserved circRNA Host Genes over Kingdoms. Huo L, Zhang P, Li C, Rahim K, Hao X, Xiang B, Zhu X. Genes (Basel). 2018 In order to validate the existence of circRNAs, we performed verification by PCR amplification with a pair of outward-designed primers and a cDNA template. In total, primers and PCR reaction systems for six potential circRNAs were designed, including the circCNYPT5 whose expression was the highest among all exonic circRNAs. PCR yeast circDPEPS circRNA saccharomyces cerevisiae CNG03660 29495353 Genome-Wide Identification of circRNAs in Pathogenic Basidiomycetous Yeast Cryptococcus neoformans Suggests Conserved circRNA Host Genes over Kingdoms. Huo L, Zhang P, Li C, Rahim K, Hao X, Xiang B, Zhu X. Genes (Basel). 2018 DBR1 Expression Level Is Negatively Associated with circDPEPS RT-PCR yeast ARP_circRNA circRNA plasmodium falciparum ARP AGAATTATTAGAGAAAAGGCGTTTAATATTAAAGTCCTATGACACCTGAAGCTCATGCAAGATGTAGAAAAAATTTTAAAAAAATTAAAATAATATAATATTGAAAATGTTGTATTTATTTATGCCAATATATAATTTTTTTTTTTTTTTTTTTTTTTTTTTTGAAGTGTTAGGATTGCAATAGTTAAAGAAGAACAGGCTAGAAAGATAGAAGATATTATTATAAGA malaria 26070627 Strand-specific RNA sequencing in Plasmodium falciparum malaria identifies developmentally regulated long non-coding RNA and circular RNA. Broadbent KM, Broadbent JC, Ribacke U, Wirth D, Rinn JL, Sabeti PC. BMC Genomics. 2015 Our results confirmed the non-canonical ARP_circRNA splice junction in cDNA preparations from either biological replicate time course. Sequence confirmation for the ARP_circRNA divergent amplicon is shown, where the GTAG splice donor-acceptor tag is included in the predicted sequence as a marker for the circRNA splice junction. PCR, sanger sequencing plasmodium Pf3D7_0414900_circRNA circRNA plasmodium falciparum Pf3D7_0414900 malaria 26070627 Strand-specific RNA sequencing in Plasmodium falciparum malaria identifies developmentally regulated long non-coding RNA and circular RNA. Broadbent KM, Broadbent JC, Ribacke U, Wirth D, Rinn JL, Sabeti PC. BMC Genomics. 2015 In total, we were able to validate six out of nine tested candidates. This circRNA was one of the validated circRNAs. PCR, sanger sequencing plasmodium Pf3D7_0817700_circRNA circRNA plasmodium falciparum Pf3D7_0817700 malaria 26070627 Strand-specific RNA sequencing in Plasmodium falciparum malaria identifies developmentally regulated long non-coding RNA and circular RNA. Broadbent KM, Broadbent JC, Ribacke U, Wirth D, Rinn JL, Sabeti PC. BMC Genomics. 2015 In total, we were able to validate six out of nine tested candidates. This circRNA was one of the validated circRNAs. PCR, sanger sequencing plasmodium Pf3D7_0936800_circRNA circRNA plasmodium falciparum Pf3D7_0936800 malaria 26070627 Strand-specific RNA sequencing in Plasmodium falciparum malaria identifies developmentally regulated long non-coding RNA and circular RNA. Broadbent KM, Broadbent JC, Ribacke U, Wirth D, Rinn JL, Sabeti PC. BMC Genomics. 2015 In total, we were able to validate six out of nine tested candidates. This circRNA was one of the validated circRNAs. PCR, sanger sequencing plasmodium Pf3D7_1438400_circRNA circRNA plasmodium falciparum Pf3D7_1438400 malaria 26070627 Strand-specific RNA sequencing in Plasmodium falciparum malaria identifies developmentally regulated long non-coding RNA and circular RNA. Broadbent KM, Broadbent JC, Ribacke U, Wirth D, Rinn JL, Sabeti PC. BMC Genomics. 2015 In total, we were able to validate six out of nine tested candidates. This circRNA was one of the validated circRNAs. PCR, sanger sequencing plasmodium Pf3D7_1474200_circRNA circRNA plasmodium falciparum Pf3D7_1474200 malaria 26070627 Strand-specific RNA sequencing in Plasmodium falciparum malaria identifies developmentally regulated long non-coding RNA and circular RNA. Broadbent KM, Broadbent JC, Ribacke U, Wirth D, Rinn JL, Sabeti PC. BMC Genomics. 2015 In total, we were able to validate six out of nine tested candidates. This circRNA was one of the validated circRNAs. PCR, sanger sequencing plasmodium circRNA MAL13P1.337 circRNA plasmodium falciparum MAL13P1.337 24609083 Circular RNA is expressed across the eukaryotic tree of life. Wang PL, Bao Y, Yee MC, Barrett SP, Hogan GJ, Olsen MN, Dinneny JR, Brown PO, Salzman J. PLoS One. 2014 This circRNA was validated experimentally. PCR, sanger sequencing Plasmodium falciparum circRNA PF11_0156 circRNA plasmodium falciparum PF11_0156 24609083 Circular RNA is expressed across the eukaryotic tree of life. Wang PL, Bao Y, Yee MC, Barrett SP, Hogan GJ, Olsen MN, Dinneny JR, Brown PO, Salzman J. PLoS One. 2014 This circRNA was validated experimentally. PCR, sanger sequencing Plasmodium falciparum NC_030732.1:43721272-43728946- circRNA xenopus laevis atrazine exposure 29494910 Identification of circular RNAs and their alterations involved in developing male Xenopus laevis chronically exposed to atrazine. Sai L, Li L, Hu C, Qu B, Guo Q, Jia Q, Zhang Y, Bo C, Li X, Shao H, Ng JC, Peng C. Chemosphere. 2018 downregulated in X. laevis exposed to 100 ¦Ìg/L AZ. qRT-PCR,RNA-seq testis NC_030734.1:102788414-102788574- circRNA xenopus laevis atrazine exposure 29494910 Identification of circular RNAs and their alterations involved in developing male Xenopus laevis chronically exposed to atrazine. Sai L, Li L, Hu C, Qu B, Guo Q, Jia Q, Zhang Y, Bo C, Li X, Shao H, Ng JC, Peng C. Chemosphere. 2018 downregulated in X. laevis exposed to 100 ¦Ìg/L AZ. qRT-PCR,RNA-seq testis NC_030734.1:106398702-106449286+ circRNA xenopus laevis atrazine exposure 29494910 Identification of circular RNAs and their alterations involved in developing male Xenopus laevis chronically exposed to atrazine. Sai L, Li L, Hu C, Qu B, Guo Q, Jia Q, Zhang Y, Bo C, Li X, Shao H, Ng JC, Peng C. Chemosphere. 2018 downregulated in X. laevis exposed to 100 ¦Ìg/L AZ. qRT-PCR,RNA-seq testis NC_030735.1:109227383-109290634- circRNA xenopus laevis atrazine exposure 29494910 Identification of circular RNAs and their alterations involved in developing male Xenopus laevis chronically exposed to atrazine. Sai L, Li L, Hu C, Qu B, Guo Q, Jia Q, Zhang Y, Bo C, Li X, Shao H, Ng JC, Peng C. Chemosphere. 2018 downregulated in X. laevis exposed to 100 ¦Ìg/L AZ. qRT-PCR,RNA-seq testis NC_030737.1:31865134-31952348- circRNA xenopus laevis atrazine exposure 29494910 Identification of circular RNAs and their alterations involved in developing male Xenopus laevis chronically exposed to atrazine. Sai L, Li L, Hu C, Qu B, Guo Q, Jia Q, Zhang Y, Bo C, Li X, Shao H, Ng JC, Peng C. Chemosphere. 2018 downregulated in X. laevis exposed to 100 ¦Ìg/L AZ. qRT-PCR,RNA-seq testis NW_016694872.1:550852-632532- circRNA xenopus laevis atrazine exposure 29494910 Identification of circular RNAs and their alterations involved in developing male Xenopus laevis chronically exposed to atrazine. Sai L, Li L, Hu C, Qu B, Guo Q, Jia Q, Zhang Y, Bo C, Li X, Shao H, Ng JC, Peng C. Chemosphere. 2018 downregulated in X. laevis exposed to 100 ¦Ìg/L AZ. qRT-PCR,RNA-seq testis NC_030738.1:21126033-21131815+ circRNA xenopus laevis atrazine exposure 29494910 Identification of circular RNAs and their alterations involved in developing male Xenopus laevis chronically exposed to atrazine. Sai L, Li L, Hu C, Qu B, Guo Q, Jia Q, Zhang Y, Bo C, Li X, Shao H, Ng JC, Peng C. Chemosphere. 2018 upregulated in X. laevis exposed to 100 ¦Ìg/L AZ. qRT-PCR,RNA-seq testis NC_030738.1:39776310-39778799- circRNA xenopus laevis atrazine exposure 29494910 Identification of circular RNAs and their alterations involved in developing male Xenopus laevis chronically exposed to atrazine. Sai L, Li L, Hu C, Qu B, Guo Q, Jia Q, Zhang Y, Bo C, Li X, Shao H, Ng JC, Peng C. Chemosphere. 2018 upregulated in X. laevis exposed to 100 ¦Ìg/L AZ. qRT-PCR,RNA-seq testis circRNA1005 circRNA cercopithecus aethiops VCAN SV40 infection 29228714 Unique expression signatures of circular RNAs in response to DNA tumor virus SV40 infection. Shi J, Hu N, Li J, Zeng Z, Mo L, Sun J, Wu M, Hu Y. Oncotarget. 2017 As expected, the expression and backplicing junctions of the selected circRNAs, including circRNA1273, circRNA1040, circRNA1005, circRNA1013, circRNA1220, circRNA1195 and circRNA1088, were confirmed by RT-PCR in the total RNA and RNase R-treated RNA samples. Backsplicing junctions of circRNAs were amplified only in cDNA samples and further validated by Sanger sequencing. qRT-PCR, sanger sequencing the African green monkey kidney (AGMK)-derived Vero cells circRNA1013 circRNA cercopithecus aethiops CAST SV40 infection 29228714 Unique expression signatures of circular RNAs in response to DNA tumor virus SV40 infection. Shi J, Hu N, Li J, Zeng Z, Mo L, Sun J, Wu M, Hu Y. Oncotarget. 2017 As expected, the expression and backplicing junctions of the selected circRNAs, including circRNA1273, circRNA1040, circRNA1005, circRNA1013, circRNA1220, circRNA1195 and circRNA1088, were confirmed by RT-PCR in the total RNA and RNase R-treated RNA samples. Backsplicing junctions of circRNAs were amplified only in cDNA samples and further validated by Sanger sequencing. qRT-PCR, sanger sequencing the African green monkey kidney (AGMK)-derived Vero cells circRNA1040 circRNA cercopithecus aethiops FNDC3B SV40 infection 29228714 Unique expression signatures of circular RNAs in response to DNA tumor virus SV40 infection. Shi J, Hu N, Li J, Zeng Z, Mo L, Sun J, Wu M, Hu Y. Oncotarget. 2017 As expected, the expression and backplicing junctions of the selected circRNAs, including circRNA1273, circRNA1040, circRNA1005, circRNA1013, circRNA1220, circRNA1195 and circRNA1088, were confirmed by RT-PCR in the total RNA and RNase R-treated RNA samples. Backsplicing junctions of circRNAs were amplified only in cDNA samples and further validated by Sanger sequencing. qRT-PCR, sanger sequencing the African green monkey kidney (AGMK)-derived Vero cells circRNA1088 circRNA cercopithecus aethiops MRPL3 SV40 infection 29228714 Unique expression signatures of circular RNAs in response to DNA tumor virus SV40 infection. Shi J, Hu N, Li J, Zeng Z, Mo L, Sun J, Wu M, Hu Y. Oncotarget. 2017 As expected, the expression and backplicing junctions of the selected circRNAs, including circRNA1273, circRNA1040, circRNA1005, circRNA1013, circRNA1220, circRNA1195 and circRNA1088, were confirmed by RT-PCR in the total RNA and RNase R-treated RNA samples. Backsplicing junctions of circRNAs were amplified only in cDNA samples and further validated by Sanger sequencing. qRT-PCR, sanger sequencing the African green monkey kidney (AGMK)-derived Vero cells circRNA1195 circRNA cercopithecus aethiops CCSER2 SV40 infection 29228714 Unique expression signatures of circular RNAs in response to DNA tumor virus SV40 infection. Shi J, Hu N, Li J, Zeng Z, Mo L, Sun J, Wu M, Hu Y. Oncotarget. 2017 As expected, the expression and backplicing junctions of the selected circRNAs, including circRNA1273, circRNA1040, circRNA1005, circRNA1013, circRNA1220, circRNA1195 and circRNA1088, were confirmed by RT-PCR in the total RNA and RNase R-treated RNA samples. Backsplicing junctions of circRNAs were amplified only in cDNA samples and further validated by Sanger sequencing. qRT-PCR, sanger sequencing the African green monkey kidney (AGMK)-derived Vero cells circRNA1220 circRNA cercopithecus aethiops DDX21 SV40 infection 29228714 Unique expression signatures of circular RNAs in response to DNA tumor virus SV40 infection. Shi J, Hu N, Li J, Zeng Z, Mo L, Sun J, Wu M, Hu Y. Oncotarget. 2017 As expected, the expression and backplicing junctions of the selected circRNAs, including circRNA1273, circRNA1040, circRNA1005, circRNA1013, circRNA1220, circRNA1195 and circRNA1088, were confirmed by RT-PCR in the total RNA and RNase R-treated RNA samples. Backsplicing junctions of circRNAs were amplified only in cDNA samples and further validated by Sanger sequencing. qRT-PCR, sanger sequencing the African green monkey kidney (AGMK)-derived Vero cells circRNA1273 circRNA cercopithecus aethiops SHOC2 SV40 infection 29228714 Unique expression signatures of circular RNAs in response to DNA tumor virus SV40 infection. Shi J, Hu N, Li J, Zeng Z, Mo L, Sun J, Wu M, Hu Y. Oncotarget. 2017 As expected, the expression and backplicing junctions of the selected circRNAs, including circRNA1273, circRNA1040, circRNA1005, circRNA1013, circRNA1220, circRNA1195 and circRNA1088, were confirmed by RT-PCR in the total RNA and RNase R-treated RNA samples. Backsplicing junctions of circRNAs were amplified only in cDNA samples and further validated by Sanger sequencing. qRT-PCR, sanger sequencing the African green monkey kidney (AGMK)-derived Vero cells circRNA mrps16 circRNA schizosaccharomyces pombe mrps16 24609083 Circular RNA is expressed across the eukaryotic tree of life. Wang PL, Bao Y, Yee MC, Barrett SP, Hogan GJ, Olsen MN, Dinneny JR, Brown PO, Salzman J. PLoS One. 2014 This circRNA was validated experimentally. PCR, sanger sequencing Schizosaccharomyces pombe circRNA pub1 circRNA schizosaccharomyces pombe pub1 24609083 Circular RNA is expressed across the eukaryotic tree of life. Wang PL, Bao Y, Yee MC, Barrett SP, Hogan GJ, Olsen MN, Dinneny JR, Brown PO, Salzman J. PLoS One. 2014 This circRNA was validated experimentally. PCR, sanger sequencing Schizosaccharomyces pombe circRNA SPAC57A7.13 circRNA schizosaccharomyces pombe SPAC57A7.13 24609083 Circular RNA is expressed across the eukaryotic tree of life. Wang PL, Bao Y, Yee MC, Barrett SP, Hogan GJ, Olsen MN, Dinneny JR, Brown PO, Salzman J. PLoS One. 2014 This circRNA was validated experimentally. PCR, sanger sequencing Schizosaccharomyces pombe circRNA ypt5 circRNA schizosaccharomyces pombe ypt5 24609083 Circular RNA is expressed across the eukaryotic tree of life. Wang PL, Bao Y, Yee MC, Barrett SP, Hogan GJ, Olsen MN, Dinneny JR, Brown PO, Salzman J. PLoS One. 2014 This circRNA was validated experimentally. PCR, sanger sequencing Schizosaccharomyces pombe circ_mrps16 circRNA schizosaccharomyces pombe mrps16 26057830 Circular RNA biogenesis can proceed through an exon-containing lariat precursor. Barrett SP, Wang PL, Salzman J. Elife. 2015 expreseed in wild-type and dbr1¦¤ S. pombe RT-PCR wild-type and dbr1¦¤ S. pombe circRNA CYP87A2 circRNA arabidopsis thaliana CYP87A2 24609083 Circular RNA is expressed across the eukaryotic tree of life. Wang PL, Bao Y, Yee MC, Barrett SP, Hogan GJ, Olsen MN, Dinneny JR, Brown PO, Salzman J. PLoS One. 2014 This circRNA was validated experimentally. PCR, sanger sequencing Arabidopsis thaliana circRNA EMB2423 circRNA arabidopsis thaliana EMB2423 24609083 Circular RNA is expressed across the eukaryotic tree of life. Wang PL, Bao Y, Yee MC, Barrett SP, Hogan GJ, Olsen MN, Dinneny JR, Brown PO, Salzman J. PLoS One. 2014 This circRNA was validated experimentally. PCR, sanger sequencing Arabidopsis thaliana circRNA NPY4 circRNA arabidopsis thaliana NPY4 24609083 Circular RNA is expressed across the eukaryotic tree of life. Wang PL, Bao Y, Yee MC, Barrett SP, Hogan GJ, Olsen MN, Dinneny JR, Brown PO, Salzman J. PLoS One. 2014 This circRNA was validated experimentally. PCR, sanger sequencing Arabidopsis thaliana circRNA cxdA circRNA dictyostelium discoideum cxdA 24609083 Circular RNA is expressed across the eukaryotic tree of life. Wang PL, Bao Y, Yee MC, Barrett SP, Hogan GJ, Olsen MN, Dinneny JR, Brown PO, Salzman J. PLoS One. 2014 This circRNA was validated experimentally. PCR, sanger sequencing Dictyostelium discoideum circRNA DDB_G0285245 circRNA dictyostelium discoideum DDB_G0285245 24609083 Circular RNA is expressed across the eukaryotic tree of life. Wang PL, Bao Y, Yee MC, Barrett SP, Hogan GJ, Olsen MN, Dinneny JR, Brown PO, Salzman J. PLoS One. 2014 This circRNA was validated experimentally. PCR, sanger sequencing Dictyostelium discoideum circRNA rsmM circRNA dictyostelium discoideum rsmM 24609083 Circular RNA is expressed across the eukaryotic tree of life. Wang PL, Bao Y, Yee MC, Barrett SP, Hogan GJ, Olsen MN, Dinneny JR, Brown PO, Salzman J. PLoS One. 2014 This circRNA was validated experimentally. PCR, sanger sequencing Dictyostelium discoideum dme_circ_0001871 circRNA drosophila melanogaster Laccase2 dme_circ_0001871 26450910 Combinatorial control of Drosophila circular RNA expression by intronic repeats, hnRNPs, and SR proteins. Kramer MC, Liang D, Tatomer DC, Gold B, March ZM, Cherry S, Wilusz JE. Genes Dev. 2015 A 490-nt transcript derived from the laccase2 gene were detected in S2 and DL1 cells. Notably, unlike the PlexA locus, the 490-nt Laccase2 transcript was more abundant (approximately fivefold and 2.5-fold in DL1 and S2 cells, respectively) than the linear Laccase2 mRNA, which encodes an enzyme implicated in cuticle formation and pigmentation. northern blots S2 and DL1 cells circMbl3 circRNA drosophila melanogaster Mbl dme_circ_0002508 28344080 Translation of CircRNAs. Pamudurti NR, Bartok O, Jens M, Ashwal-Fluss R, Stottmeister C, Ruhe L, Hanan M, Wyler E, Perez-Hernandez D, Ramberger E, Shenzis S, Samson M, Dittmar G, Landthaler M, Chekulaeva M, Rajewsky N, Kadener S. Mol Cell. 2017 We found that a circRNA generated from the muscleblind locus encodes a protein, which we detected in fly head extracts by mass spectrometry. Next, by performing in vivo and in vitro translation assays, we show that UTRs of ribo-circRNAs (cUTRs) allow cap-independent translation. Moreover, we found that starvation and FOXO likely regulate the translation of a circMbl isoform. mass spectrometry fly heads, S2 cells tric31905 circRNA drosophila melanogaster CR31905 AGTTTCCGAGGCTTGGTGATGCGAGCAGAGGCAGGACTCTGGGCCAAACAATACCATGGCCCCAGATAGCGCTTGCTCTTGTTTCATCAGTTAGTGAATCGCGATATGTTGAA 26194134 Metazoan tRNA introns generate stable circular RNAs in vivo. Lu Z, Filonov GS, Noto JJ, Schmidt CA, Hatkevich TL, Wen Y, Jaffrey SR, Matera AG. RNA. 2015 Collectively, these experiments demonstrate that splicing of the CR31905 transcript generates a stable intronic RNA, termed tric31905, and that the predominant form of this molecule is circular. We examined expression of tric31905 over developmental time and found that its levels increase substantially from embryos to adults. In contrast, expression of the mature tRNA (TyrGUA) was relatively constant. Notably, tric31905 expression was slightly lower in adult females, perhaps because the ovary is such a large organ and expression levels in these tissues were relatively low. Consistent with their embryonic origin, Schneider2 cells also showed relatively low levels. qRT-PCR, northern blots fly larvae, pupae and adults circ_gene16803 circRNA micropogonias undulatus gene16803 28089131 Transcriptome-wide identification and functional investigation of circular RNA in the teleost large yellow croaker (Larimichthys crocea). Xu S, Xiao S, Qiu C, Wang Z. Mar Genomics. 2017 Our PCR experiments confirmed that there is a splice junction in circ_gene16803. We then sequenced the cDNA amplification product for circ_gene16803 by Sanger sequencing and further validated the junction sequences of circ_gene16803. RT-PCR, sanger sequencing mixed samples from multi-tissues, including the liver, kidney, heart, gonad, spleen and brain. circ_gene5180 circRNA micropogonias undulatus gene5180 28089131 Transcriptome-wide identification and functional investigation of circular RNA in the teleost large yellow croaker (Larimichthys crocea). Xu S, Xiao S, Qiu C, Wang Z. Mar Genomics. 2017 Our PCR experiments confirmed that there is a splice junction in circ_gene5180. We then sequenced the cDNA amplification product for circ_gene5180 by Sanger sequencing and further validated the junction sequences of circ_gene5180. RT-PCR, sanger sequencing mixed samples from multi-tissues, including the liver, kidney, heart, gonad, spleen and brain. FLC (full-length circular group I intron RNAs) circRNA didymium iridis 27809244 Accumulation of Stable Full-Length Circular Group I Intron RNAs during Heat-Shock. Andersen KL, Beckert B, Masquida B, Johansen SD, Nielsen H. Molecules. 2016 During heat-shock, the circular form is up-regulated. qRT-PCR Didymium iridis strain Lat3¨C5