RefCirc
a reference database for circRNAs validated by experiments

circATP2B1 Details
Basic Information
circRNA    circATP2B1
Alias    hsa_circ_000826
circBase ID    hsa_circ_0000426
Host gene    ATP2B1
Species    homo sapiens
Peptide    -
Sequence  ATGTGTATATCTCATGATTGATATGGAGAAACTAGTCATGGGCCAAAGGTCAAGATACTTCTCTGGGAAATGTTGCTGCTGATGCTGCTTTACAAAGTCATACAATGAGTGTTTGGTTTAAGAAAGATTTTCATACTTAAAAGATTTTCATCTTGGAAATACATCAAGTGAAAATTAAATTCTTTTGGGAAACATTTTCCTTCTGATATATTATACTTGTAATGGGCGACATGGCAAACAACTCAGTTGCTTACAGTGGTGTGAAAAACTCTTTGAAGGAAGCTAATCATGATGGAGACTTTGGAATTACGCTCGCAGAGCTGCGGGCTCTCATGGAGCTCAGGTCCACAGATGCATTACGAAAAATACAGGAAAGCTATGGAGATGTCTATGGAATTTGCACCAAATTGAAAACATCTCCCAATGAAGGTTTAAGTGGAAACCCTGCAGATTTAGAAAGAAGAGAAGCAGTGTTTGGAAAGAATTTTATACCTCCTAAAAAGCCAAAAACCTTTCTTCAATTAGTATGGGAAGCATTACAAGATGTCACTTTAATTATATTAGAAATTGCAGCCATAGTATCATTGGGCCTTTCTTTTTATCAGCCTCCAGAAGGGGATAATGCAC
Expression
Description  The expression of circATP2B1 is significantly decreased when ERbeta was knocked down in 786-O cells, and is significantly increased after over-expressing ERbeta in A498 cells.
Method    qRT-PCR
Sample    786-O, A498
Function
Description  ERbeta/circATP2B1/miR204-3p axis enhanced ccRCC cell invasion via altering the FN1 expression.
Method    loss of function, gain of function
in vitro    786-O, A498, Caki-1, HEK-293
in vivo    NCr-nu/nu female mice
Interaction
Target    miR-204-3p
Type    circRNA-miRNA
Sample    786-O, A498
Experiment    RNA pull-down
Description    circATP2B1 can directly interact with miR-204-3p by RNA pull-down assay.
ceRNA target    FN1
Reference
Pubmed ID    29490945
Trait/Disease    Clear Cell Renal Cell Carcinoma
Title    ERbeta-mediated alteration of circATP2B1 and miR-204-3p signaling promotes invasion of clear cell renal cell carcinoma.
Authors    Han Z, Zhang Y, Sun Y, Chen J, Chang C, Wang X, Yeh S.
Journal    Cancer Res. 2018