RefCirc
a reference database for circRNAs validated by experiments

circHLA-C Details
Basic Information
circRNA    circHLA-C
Alias    -
circBase ID    -
Host gene    HLA-C
Species    homo sapiens
Peptide    -
Sequence  -
Expression
Description  Significantly upregulated in LN renal biopsies compared with NC kidneys. circHLA-C positively correlated with total proteinuria excretion per day (R = 0.920, p = 0.009), serum creatinine levels (R = 0.756, p = 0.082), percentage of crescentic glomeruli in total glomeruli (R = 0.929, p = 0.6007), and renal active index (AI) scores (R = 0.884, p = 0.020).
Method    RNA-seq, qRT-PCR
Sample    lupus nephritis renal biopsies and negtive control kidneys
Function
Description  -
Method    -
in vitro    -
in vivo    -
Interaction
Target    miR-150
Type    circRNA-miRNA
Sample    -
Experiment    predicted
Description    circHLA-C had a perfect match sequence (7-mer-m8 seed type) to bind miR-150.
ceRNA target    -
Reference
Pubmed ID    29499937
Trait/Disease    Lupus Nephritis
Title    circHLA-C Plays an Important Role in Lupus Nephritis by Sponging miR-150.
Authors    Luan J, Jiao C, Kong W, Fu J, Qu W, Chen Y, Zhu X, Zeng Y, Guo G, Qi H, Yao L, Pi J, Wang L, Zhou H.
Journal    Mol Ther Nucleic Acids. 2018