RefCirc
a reference database for circRNAs validated by experiments

circ-SHKBP1 Details
Basic Information
circRNA    circ-SHKBP1
Alias    -
circBase ID    -
Host gene    SHKBP1
Species    homo sapiens
Peptide    -
Sequence  -
Expression
Description  Upregulated in Glioma
Method    qRT-PCR
Sample    Human glioma tissue specimens, normal brain tissues, U87, hCMEC/D3
Function
Description  Knockdown of circ-SHKBP1 Inhibited the Angiogenesis of GECs and the Expression of AGGF1
Method    loss of function
in vitro    U87
in vivo    Four-week-old BALB/C athymic nude mice
Interaction
Target    miR-544a, miR-379
Type    circRNA-miRNA
Sample    HEK293T
Experiment    luciferase reporter assay
Description    the relative luciferase activity was significantly reduced in the SHKBP1 WT + miR-544a (+) group and the SHKBP1 WT + miR-379 (+) group
ceRNA target    FOXP1,FOXP2
Reference
Pubmed ID    29499945
Trait/Disease    Glioma
Title    circ-SHKBP1 Regulates the Angiogenesis of U87 Glioma-Exposed Endothelial Cells through miR-544a/FOXP1 and miR-379/FOXP2 Pathways.
Authors    He Q, Zhao L, Liu Y, Liu X, Zheng J, Yu H, Cai H, Ma J, Liu L, Wang P, Li Z, Xue Y.
Journal    Mol Ther Nucleic Acids. 2018