RefCirc
a reference database for circRNAs validated by experiments

circRNA-000284 Details
Basic Information
circRNA    circRNA-000284
Alias    -
circBase ID    -
Host gene    -
Species    homo sapiens
Peptide    -
Sequence  -
Expression
Description  CircRNA-000284 is upregulated in cervical cancer cells
Method    microarray, qRT-PCR, FISH
Sample    HeLa, CaSki, SiHa, C-33A, SW756, human normal cervical epithelial cells
Function
Description  CircRNA-000284 suppresses cell proliferation and invasion via miR-506/Snail-2 pathway
Method    loss of function
in vitro    HeLa, SiHa
in vivo    -
Interaction
Target    miR-506
Type    circRNA-miRNA
Sample    HeLa
Experiment    luciferase reporter assay, AGO4 RIP
Description    CircRNA-000284 directly binds to miR-506 and suppresses miR-506 activity
ceRNA target    Snail-2
Reference
Pubmed ID    29511454
Trait/Disease    Cervical Cancer
Title    Extensive profiling of circular RNAs and the potential regulatory role of circRNA-000284 in cell proliferation and invasion of cervical cancer via sponging miR-506.
Authors    Ma HB, Yao YN, Yu JJ, Chen XX, Li HF.
Journal    Am J Transl Res. 2018