RefCirc
a reference database for circRNAs validated by experiments

CircHIPK3 Details
Basic Information
circRNA    CircHIPK3
Alias    -
circBase ID    -
Host gene    HIPK3
Species    homo sapiens
Peptide    -
Sequence  -
Expression
Description  CircHIPK3 is significantly upregulated in CRC
Method    qRT-PCR
Sample    CRC cell lines (HCT116, HT29, SW480, SW620, DLD1), CRC tumor and matched normal tissues.
Function
Description  Silencing of circHIPK3 inhibits CRC cells proliferation, migration, invasion, and induces apoptosis in vitro. Silencing of circHIPK3 combined with overexpression of miR-7 exhibits an additive inhibitory effect on CRC growth and metastasis in xenograft animal models.
Method    loss of function
in vitro    HCT116 and HT29 cells
in vivo    5-week-old male BALB/c nude mice
Interaction
Target    miR-7
Type    circRNA-miRNA
Sample    HCT116 and HT29 cells
Experiment    RNA pull-down
Description    qRT-PCR analyses revealed that miR-7 was the only one miRNA that was abundantly pulled down by circHIPK3 probe in both HCT116 and HT29 cells.
ceRNA target    FAK, IGF1R, EGFR, and YY1
Reference
Pubmed ID    29549306
Trait/Disease    Colorectal Cancer
Title    CircHIPK3 promotes colorectal cancer growth and metastasis by sponging miR-7.
Authors    Zeng K, Chen X, Xu M, Liu X, Hu X, Xu T, Sun H, Pan Y, He B, Wang S.
Journal    Cell Death Dis. 2018