RefCirc
a reference database for circRNAs validated by experiments

circMAN2B2 Details
Basic Information
circRNA    circMAN2B2
Alias    -
circBase ID    -
Host gene    MAN2B2
Species    homo sapiens
Peptide    -
Sequence  -
Expression
Description  a highly expressed novel circRNA named circMAN2B2 in lung cancer tissues
Method    microarray, qRT-PCR
Sample    Tissue samples of lung cancer and paired normal tissues. BESA-2B, A549, H226, H1299 and H446
Function
Description  circMAN2B2 knockdown significantly inhibited cell proliferation and invasion in both H1299 and A549 lung cancer cells.
Method    loss of function
in vitro    H1299, A549
in vivo    -
Interaction
Target    miR-1275
Type    circRNA-miRNA
Sample    H1299 and A549
Experiment    luciferase reporter assay
Description    Luciferase activity was repressed in H1299 and A549 cells co-transfected with wild-type (WT) circ- MAN2B2 and miR-1275 mimics
ceRNA target    FOXK1
Reference
Pubmed ID    29550475
Trait/Disease    Lung Cancer
Title    Circular RNA circMAN2B2 facilitates lung cancer cell proliferation and invasion via miR-1275/FOXK1 axis.
Authors    Ma X, Yang X, Bao W, Li S, Liang S, Sun Y, Zhao Y, Wang J, Zhao C.
Journal    Biochem Biophys Res Commun. 2018