RefCirc
a reference database for circRNAs validated by experiments

hsa_circ_0014717 Details
Basic Information
circRNA    hsa_circ_0014717
Alias    -
circBase ID    hsa_circ_0014717
Host gene    CCT3
Species    homo sapiens
Peptide    -
Sequence  ACTATTGCAGATATCATCCGAACATGTTTGGGACCCAAGTCCATGATGAAGATGCTTTTGGACCCAATGGGAGGCATTGTGATGACCAATGATGGCAATGCCATTCTTCGAGAGATTCAAGTCCAGCATCCAGCGGCCAAGTCCATGATCGAAATTAGCCGGACCCAGGATGAAGAGGTTGGAGATGGGACCACATCAGTAATTATTCTTGCAGGGGAAATGCTGTCTGTAGCTGAGCACTTCCTGGAGCAGCAGATGCACCCAACAGTGGTGATCAGTGCTTACCGCAAGGCATTGGATGATATGATCAGCACCCTAAAGAAAATAAGTATCCCAGTCGACATCAGTGACAGTGATATGATGCTGAACATCATCAACAGCTCTATTACTACCAAAGCCATCAGTCGGTGGTCATCTTTGGCTTGCAACATTGCCCTGGATGCTGTCAAGATGGTACAGTTTGAGGAGAATGGTCGGAAAGAGATTGACATAAAAAAATATGCAAGAGTGGAAAAG
Expression
Description  Hsa_circ_0014717 was downregulated in CRC
Method    qRT-PCR
Sample    cancer tissues and pair-matched adjacent normal tissues, HCT116, HT29 and SW480
Function
Description  Reduced expression of hsa_circ_0014717 might be associated with the progression, deterioration and poor prognosis of CRC. Hsa_circ_0014717 could inhibit CRC cell proliferation and colony formation, as well as induce cell cycle arrest at G0/G1 phase. Hsa_circ_0014717 could suppress tumorigenesis of CRC cells in vivo.
Method    gain of function
in vitro    HT29, HCT116
in vivo    6-week-old BALB/c athymic nude mice
Interaction
Target    -
Type    -
Sample    -
Experiment    -
Description    -
ceRNA target    -
Reference
Pubmed ID    29571246
Trait/Disease    Colorectal Cancer
Title    Hsa_circ_0014717 is downregulated in colorectal cancer and inhibits tumor growth by promoting p16 expression.
Authors    Wang F, Wang J, Cao X, Xu L, Chen L.
Journal    Biomed Pharmacother. 2018