RefCirc
a reference database for circRNAs validated by experiments

hsa_circ_0011946 Details
Basic Information
circRNA    hsa_circ_0011946
Alias    -
circBase ID    hsa_circ_0011946
Host gene    SCMH1
Species    homo sapiens
Peptide    -
Sequence  CATCTAGTGCTTTTTGCATGGCCCAAAGGGGCTCTGTGCTGCTCCACTACAGAGGAAACTTCAAGAAATGCTGGTTTGCTACAGTGTTTTAGCTTGTGAGATTCTCTGGGACCTTCCCTGCTCCATCATGGGGTCACCTCTAGGTCATTTTACCTGGGACAAATACCTAAAAGAAACATGTTCAGTCCCAGCGCCTGTCCATTGCTTCAAGCAGTCCTACACACCTCCAAGCAACGAGTTCAAGATCAGTATGAAATTGGAAGCACAGGACCCCAGGAACACCACATCCACCTGTATTGCCACAGTAGTTGGACTGACAGGTGCCCGCCTTCGCCTGCGCCTTGATGGGAGCGACAACAAAAATGACTTCTGGCGGCTGGTTGACTCAGCTGAAATCCAGCCTATTGGGAACTGTGAAAAGAATGGGGGTATGCTACAGCCACCTCTTGGATTTCGGCTGAATGCGTCTTCTTGGCCCATGTTCCTTTTGAAGACGCTAAATGGAGCAGAGATGGCTCCCATCAGGATTTTCCACAAGGAGCCACCATCGCCTTCCCACAACTTCTTCAAAATGGGAATGAAGCTAGAAGCTGTGGACAGGAAGAACCCTCATTTCATTTGCCCAGCCACTATTGGGGAGGTTCGGGGCTCAGAGGTGCTTGTCACTTTTGATGGGTGGCGAGGGGCCTTTGACTACTGGTGCCGCTTCGACTCCCGAGACATCTTCCCTGTGGGCTGGTGTTCCTTGACTGGAGACAACCTGCAGCCTCCTGGCACCAAAG
Expression
Description  up-regulated in both cells and breast cancer tissues
Method    RNA-seq, qRT-PCR
Sample    breast cancer and corresponding adjacent non-cancerous tissues, HS-578T, T47D, MCF-7, BT549, MDA-MB-231, and SKBR-3
Function
Description  Downregulated hsa_circ_0011946 inhibited RFC3 expression and migration, and invasion in MCF-7 cells.
Method    loss of function
in vitro    MCF-7
in vivo    -
Interaction
Target    miR-26a/b
Type    circRNA-miRNA
Sample    MCF-7 and MDA-MB-231
Experiment    predicted
Description    From these studies, we deduced that hsa_circ_0011946, as a miRNA sponge, might regulate the progression of breast cancer by binding up miR-26a/b, miR-200b/c, and miR-429.
ceRNA target    RFC3
Reference
Pubmed ID    29593432
Trait/Disease    Breast Cancer
Title    Downregulation of hsa_circ_0011946 suppresses the migration and invasion of the breast cancer cell line MCF-7 by targeting RFC3.
Authors    Zhou J, Zhang WW, Peng F, Sun JY, He ZY, Wu SG.
Journal    Cancer Manag Res. 2018