RefCirc
a reference database for circRNAs validated by experiments

ciRS-7 Details
Basic Information
circRNA    ciRS-7
Alias    Cdr1as
circBase ID    -
Host gene    Cdr1
Species    mus musculus
Peptide    -
Sequence  -
Expression
Description  Cdr1as was found to express in MIN6 cells, mouse islets, brain, pituitary gland and AtT-20 cells. expressed in islet cells and was upregulated by long-term forskolin and PMA stimulation.
Method    qRT-PCR, sanger sequencing
Sample    MIN6 cells, mouse islets, brain, pituitary gland and AtT-20 cells.
Function
Description  Cdr1as increased insulin secretion. Both insulin content and secretion were significantly increased by overexpression of Cdr1as in islet cells.
Method    gain of function
in vitro    MIN6, AtT-20
in vivo    -
Interaction
Target    miR-7
Type    circRNA-miRNA
Sample    MIN6, islets
Experiment    qRT-PCR
Description    Cdr1as upregulates miR-7 target genes expression.
ceRNA target    Myrip, Pax6
Reference
Pubmed ID    26211738
Trait/Disease    -
Title    The circular RNA Cdr1as, via miR-7 and its targets, regulates insulin transcription and secretion in islet cells.
Authors    Xu H, Guo S, Li W, Yu P.
Journal    Sci Rep. 2015