RefCirc
a reference database for circRNAs validated by experiments

heart-related circRNA (HRCR) Details
Basic Information
circRNA    heart-related circRNA (HRCR)
Alias    -
circBase ID    -
Host gene    -
Species    mus musculus
Peptide    -
Sequence  -
Expression
Description  expressed in cardiomyocytes and mouse heart
Method    qRT-PCR, northern blots, FISH
Sample    adult male C57BL/6 mice (8-10weeks old), cardiomyocytes
Function
Description  acts as an endogenous miR-223 sponge to inhibit cardiac hypertrophy and heart failure
Method    gain of function
in vitro    cardiomyocytes
in vivo    adult male C57BL/6 mice (8-10weeks old)
Interaction
Target    miR-223
Type    circRNA-miRNA
Sample    mouse heart
Experiment    AGO2 IP, RNA pull-down, FISH
Description    Fluorescence in situ hybridization (FISH) revealed that there is a co-localization between HRCR and miR-223 in cytoplasm. HRCR could pull down miR-223. HRCR pull down by AGO2 was specifically enriched in miR-223-transfected cells but not miR-223 mutant-transfected cells.
ceRNA target    ARC
Reference
Pubmed ID    26802132
Trait/Disease    Cardiac Hypertrophy and Heart Failure
Title    A circular RNA protects the heart from pathological hypertrophy and heart failure by targeting miR-223.
Authors    Wang K, Long B, Liu F, Wang JX, Liu CY, Zhao B, Zhou LY, Sun T, Wang M, Yu T, Gong Y, Liu J, Dong YH, Li N, Li PF.
Journal    Eur Heart J. 2016