RefCirc
a reference database for circRNAs validated by experiments

ciRS-7 Details
Basic Information
circRNA    ciRS-7
Alias    Cdr1as
circBase ID    -
Host gene    Cdr1
Species    mus musculus
Peptide    -
Sequence  -
Expression
Description  Co-Expression of Cdr1as and miR-7a Was Detected during MI-Induced Injury or in Hypoxia-Treated Cardiomyocytes. upregulated in MI mice with increased cardiac infarct size, or cardiomyocytes under hypoxia treatment.
Method    qRT-PCR
Sample    myocardial tissues from MI mice, primary cardiomyocytes, MCM (mouse cardiac myocytes) cells
Function
Description  Overexpression of Cdr1as Aggravated MI Injuries with Upregulated PARP and SP1, which Could Be Rescued by the Co-Overexpression of miR-7a. Cdr1as overexpression in MCM cells promoted cell apoptosis, but was then reversed by miR-7a overexpression.
Method    gain of function
in vitro    Primary cardiomyocytes, mouse cardiac myocytes, MCM cells
in vivo    Male C57BL/6 mice of 8-week-old
Interaction
Target    miR-7a/b
Type    circRNA-miRNA
Sample    MCM
Experiment    -
Description    well-identified circular RNAs (circRNAs), as a miR-7a/b sponge or inhibitor in brain tissues or islet cells
ceRNA target    PARP, SP1
Reference
Pubmed ID    26998750
Trait/Disease    Myocardial Infarction
Title    The Circular RNA Cdr1as Promotes Myocardial Infarction by Mediating the Regulation of miR-7a on Its Target Genes Expression.
Authors    Geng HH, Li R, Su YM, Xiao J, Pan M, Cai XX, Ji XP.
Journal    PLoS One. 2016