RefCirc
a reference database for circRNAs validated by experiments

circRar1 Details
Basic Information
circRNA    circRar1
Alias    -
circBase ID    -
Host gene    Rar1
Species    mus musculus
Peptide    -
Sequence  -
Expression
Description  markedly upregulated in the hippocampus. upregulated in lead-treated N2a mouse nerve cells.
Method    qRT-PCR
Sample    mouse cerebellum, pons, medulla oblongata, hippocampus and cerebral cortex. lead-treated N2a mouse nerve cells
Function
Description  circRar1 promote apoptosis in lead induced neurotoxicity
Method    loss of function, gain of function
in vitro    lead-treated N2a mouse nerve cells
in vivo    -
Interaction
Target    miR 671
Type    circRNA-miRNA
Sample    lead-treated N2a mouse nerve cells
Experiment    FISH,luciferase reporter assay
Description    These results indicate that lncRpa and circRar1 interact directly and specifically with miR-671.
ceRNA target    Akt2, caspase8, and p38
Reference
Pubmed ID    27604105
Trait/Disease    Lead Induced Neuronal Cell Apoptosis
Title    A novel regulatory network among LncRpa, CircRar1, MiR-671 and apoptotic genes promotes lead-induced neuronal cell apoptosis.
Authors    Nan A, Chen L, Zhang N, Liu Z, Yang T, Wang Z, Yang C, Jiang Y.
Journal    Arch Toxicol. 2017