RefCirc
a reference database for circRNAs validated by experiments

circRNA_000203 Details
Basic Information
circRNA    circRNA_000203
Alias    -
circBase ID    -
Host gene    Myo9a
Species    mus musculus
Peptide    -
Sequence  -
Expression
Description  CircRNA_000203 was shown upregulated in the diabetic mouse myocardium and in Ang-II-induced mouse cardiac fibroblasts.
Method    qRT-PCR
Sample    diabetic mouse myocardium
Function
Description  Enforced-expression of circRNA_000203 could increase expressions of Col1a2, Col3a1 and ??-SMA in mouse cardiac fibroblasts. over-expression of circRNA_000203 could eliminate the anti-fibrosis effect of miR-26b-5p in cardiac fibroblasts.
Method    gain of function
in vitro    mouse cardiac fibroblasts
in vivo    -
Interaction
Target    miR-26b-5p
Type    circRNA-miRNA
Sample    HEK293 cells
Experiment    RNA pull-down, qRT-PCR
Description    RNA pull-down and RT-qPCR assay indicated that circRNA_000203 could specifically sponge miR-26b-5p.
ceRNA target    Col1a2 and CTGF
Reference
Pubmed ID    28079129
Trait/Disease    Diabetic Cardiomyopathy
Title    CircRNA_000203 enhances the expression of fibrosis-associated genes by derepressing targets of miR-26b-5p, Col1a2 and CTGF, in cardiac fibroblasts.
Authors    Tang CM, Zhang M, Huang L, Hu ZQ, Zhu JN, Xiao Z, Zhang Z, Lin QX, Zheng XL, -Yang M, Wu SL, Cheng JD, Shan ZX.
Journal    Sci Rep. 2017