RefCirc
a reference database for circRNAs validated by experiments

circRNA_010567 Details
Basic Information
circRNA    circRNA_010567
Alias    -
circBase ID    -
Host gene    -
Species    mus musculus
Peptide    -
Sequence  -
Expression
Description  circRNA_010567 was markedly increased in diabetic mouse myocardium. CircRNA_010567 expression was confirmed in mouse myocardium using qRT-PCR, which showed circRNA_010567 was significantly up-regulated in myocardium.
Method    microarray, qRT-PCR
Sample    diabetic mouse myocardium
Function
Description  Functional experiments revealed circRNA_010567 silencing could up-regulate miR-141 and down-regulate TGF-b1 expression, and suppress fibrosis associated protein resection in CFs, including Col I, Col III and a-SMA. Results demonstrate the circRNA_010567/miR-141/TGF-b1 axis plays an important regulatory role in the diabetic mice myocardial fibrosis model.
Method    loss of function
in vitro    mouse cardiac fibroblasts
in vivo    -
Interaction
Target    miR-141
Type    circRNA-miRNA
Sample    db/db diabetic mice myocardium
Experiment    luciferase report assay
Description    circRNA_010567 directly targeted miR-141 and mediate it negatively.
ceRNA target    TGF-beta1
Reference
Pubmed ID    28412345
Trait/Disease    Myocardial Fibrosis
Title    A novel identified circular RNA, circRNA_010567, promotes myocardial fibrosis via suppressing miR-141 by targeting TGF-??1.
Authors    Zhou B, Yu JW.
Journal    Biochem Biophys Res Commun. 2017