RefCirc
a reference database for circRNAs validated by experiments

circ-Foxo3 Details
Basic Information
circRNA    circ-Foxo3
Alias    -
circBase ID    -
Host gene    Foxo3
Species    homo sapiens
Peptide    -
Sequence  -
Expression
Description  Three noncancerous cell lines BEAS2B, HaCaT and MCF-10A all expressed high levels of circ-Foxo3.
Method    qRT-PCR, northern blots
Sample    BEAS2B, HaCaT, MCF-10A, SK-Br3, HTB-126, MB-468, MB-231, LnCap, Du145
Function
Description  MDA-MB-231 cells transfected with circ-Foxo3 grew slower than the control vector-transfected cells did. We found that cells expressing circ-Foxo3 formed significantly smaller tumors than the control cells in vivo.
Method    gain of function
in vitro    MDA-MB-231
in vivo    nude mice
Interaction
Target    miR-22, miR-136*, miR-138, miR-149*, miR-433, miR-762, miR-3614-5p and miR-3622b-5p.
Type    circRNA-miRNA
Sample    MDA-MB-231
Experiment    RNA pull-down, luciferase reporter assay
Description    miR-22, miR-136*, miR-138, miR-149*, miR-433, miR-762, miR-3614-5p and miR-3622b-5p directly bind to circ-Foxo3.
ceRNA target    -
Reference
Pubmed ID    26657152
Trait/Disease    Tumor Growth
Title    Foxo3 activity promoted by non-coding effects of circular RNA and Foxo3 pseudogene in the inhibition of tumor growth and angiogenesis.
Authors    Yang W, Du WW, Li X, Yee AJ, Yang BB.
Journal    Oncogene. 2016