RefCirc
a reference database for circRNAs validated by experiments

f-circPR Details
Basic Information
circRNA    f-circPR
Alias    -
circBase ID    -
Host gene    PML-RARA fusion gene
Species    homo sapiens
Peptide    -
Sequence  GTACACTGGCACGGGGTGTGCCCCGGGCACTGACTGTACCACAGCCATAGGCTGGGCTTCAGCCAGCCCCAGGGCCTGAACCTGGGCCTTCACTCTCTCTGCCTCCTCGGGCAGGATGTCCAGGCAGGCAGCCTTGAGGAGGGTGATCTGGTCGGCGATGGTGAGGGTGGTGAAGCCGGGCAGCTGCTTGGCGAACTCCACAGTCTTAATGATGCACTTGGTGGAGAGTTCACTGAACTTGTCCCAGAGGTCAATGTCCAGAGAGACACGTTGTTCTGAGCTGTTGTTCGTAGTGTATTTGCCCAGCTGGCAGAGGGCAGGGAAGGTTTCCTGGTGCGCTTTGCGCACCTTCTCAATGAGCTCCCCCACCTCCGGCGTCAGCGTGTAGCTCTCAGAGCACTCGGGCTTGGGCACCTCCTTCTTCTTCTTGTTTCGGTCGTTTCTCACAGACTCCTTGGACATGCCCACTTCAAAGCACTTCTGCAGTCGGCAGTACTGGCAGCGGTTCCGGGTCACCTTGTTGATGATGCAGTTCTTGTCCCGGTGACACGTGTACACCATGTTCTTCTGGATGCTGCGGCGGAAGAAGCCCTTGCAGCCCTCACAGGCGCTG
Expression
Description  f-circPR is expressed in bone marrow(BM)-derived leukemic cells of APL patients and in APL-derived leukemic cell line NB4.
Method    PCR products sequencing
Sample    APL patients, NB4 cell line, MEFs
Function
Description  f-circPR exerts tumor promoting activity in immortalized MEFs and is involved in the tumorigenic process independent of their linear transcript and their fusion protein counterparts.
Method    loss of function, gain of function
in vitro    APL patients, NB4 cell line, MEFs
in vivo    -
Interaction
Target    -
Type    -
Sample    -
Experiment    -
Description    -
ceRNA target    -
Reference
Pubmed ID    27040497
Trait/Disease    Acute Promyelocytic Leukemia
Title    Oncogenic Role of Fusion-circRNAs Derived from Cancer-Associated Chromosomal Translocations.
Authors    Guarnerio J, Bezzi M, Jeong JC, Paffenholz SV, Berry K, Naldini MM, Lo-Coco F, Tay Y, Beck AH, Pandolfi PP.
Journal    Cell. 2016