RefCirc
a reference database for circRNAs validated by experiments

CircHIPK3 Details
Basic Information
circRNA    CircHIPK3
Alias    -
circBase ID    -
Host gene    HIPK3
Species    homo sapiens
Peptide    -
Sequence  -
Expression
Description  circHIPK3 is commonly expressed in various tissues and particularly enriched in the brain.
Method    RNA-seq, qRT-PCR, northern blots, FISH
Sample    Human normal (brain, heart, liver, lung, colon and stomach) and cancerous (primary hepatocellular carcinoma, CRC, GC, KCA, BLCA, BC and PRAD) samples. HeLa, Huh-7 and HCT-116.
Function
Description  Silencing of circHIPK3 inhibits human cell proliferation.
Method    loss of function, gain of function
in vitro    HeLa, Huh-7 and HCT-116
in vivo    -
Interaction
Target    miR-124, miR-152, miR-193a, miR-29a, miR-29b, miR-338, miR-379, miR-584 and miR-654
Type    circRNA-miRNA
Sample    HEK-293T
Experiment    AGO2 RIP, luciferase reporter assay
Description    Compared with the control RNA, 9 miRNAs (miR-124, miR-152, miR-193a, miR-29a, miR-29b, miR-338, miR-379, miR-584 and miR-654) out of the 424 miRNAs were able to reduce the luciferase reporter activities by at least 30%.
ceRNA target    IL6R and DLX2
Reference
Pubmed ID    27050392
Trait/Disease    Bladder Cancer
Title    Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs.
Authors    Zheng Q, Bao C, Guo W, Li S, Chen J, Chen B, Luo Y, Lyu D, Li Y, Shi G, Liang L, Gu J, He X, Huang S.
Journal    Nat Commun. 2016