RefCirc
a reference database for circRNAs validated by experiments

circRNA_001569 Details
Basic Information
circRNA    circRNA_001569
Alias    -
circBase ID    -
Host gene    -
Species    homo sapiens
Peptide    -
Sequence  -
Expression
Description  up-regulated in CRC
Method    qRT-PCR
Sample    CRC tissue samples and matched non-tumor normal tissue samples, HCT116, SW480, LOVO, SW620
Function
Description  hsa_circ_001569 acted as a positive regulator in cell proliferation and invasion of colorectal cancer (CRC). Moreover, hsa_circ_001569 was identified as a sponge of miR-145 and up-regulated miR-145 functional targets E2F5, BAG4 and FMNL2.
Method    loss of function, gain of function
in vitro    HCT116, SW480, LOVO, SW620
in vivo    -
Interaction
Target    miR-145
Type    circRNA-miRNA
Sample    SW480, LOVO
Experiment    luciferase reporter assay
Description    reduction of luciferase activity was observed upon the combination of circ_001569 and miR-145
ceRNA target    E2F5, BAG4 and FMNL2
Reference
Pubmed ID    27058418
Trait/Disease    Colorectal Cancer
Title    Emerging roles of circRNA_001569 targeting miR-145 in the proliferation and invasion of colorectal cancer.
Authors    Xie H, Ren X, Xin S, Lan X, Lu G, Lin Y, Yang S, Zeng Z, Liao W, Ding YQ, Liang L.
Journal    Oncotarget. 2016