RefCirc
a reference database for circRNAs validated by experiments

circTCF25 Details
Basic Information
circRNA    circTCF25
Alias    -
circBase ID    -
Host gene    TCF25
Species    homo sapiens
Peptide    -
Sequence  -
Expression
Description  up in BC
Method    microarray, qRT-PCR
Sample    bladder carcinoma tissue and matched para-carcinoma tissue, T24 and EJ cells
Function
Description  The circTCF25 promotes proliferation and migration of bladder cancer cells via circTCF25-miR-103a-3p/miR-107-CDK6 pathway.
Method    gain of function
in vitro    T24, EJ
in vivo    -
Interaction
Target    miR-103a-3p/miR-107
Type    circRNA-miRNA
Sample    T24, EJ
Experiment    expression
Description    Then, we observed that the expressions of miR-103a-3p and miR-107 were down-regulated significantly in over-expression circTCF25 group compared with mock control in T24 and EJ cells. Meanwhile, the expression levels of miR-103a-3p and miR-107 in bladder carcinoma tissues were lower than those in para-carcinoma tissues by qPCR.
ceRNA target    -
Reference
Pubmed ID    27484176
Trait/Disease    Bladder Cancer
Title    Screening differential circular RNA expression profiles reveals the regulatory role of circTCF25-miR-103a-3p/miR-107-CDK6 pathway in bladder carcinoma.
Authors    Zhong Z, Lv M, Chen J.
Journal    Sci Rep. 2016