RefCirc
a reference database for circRNAs validated by experiments

cir-ZNF609 Details
Basic Information
circRNA    cir-ZNF609
Alias    -
circBase ID    -
Host gene    ZNF609
Species    homo sapiens
Peptide    -
Sequence  -
Expression
Description  cir-ZNF609 was down-regulated in HSCR compared with normal bowel tissues.
Method    qRT-PCR
Sample    HSCR and normal bowel tissues
Function
Description  suppression of cir-ZNF609 inhibited the proliferation and migration of cells. cir-ZNF609 took part in the onset of HSCR through the crosstalk with AKT3 by competing for shared miR-150-5p.
Method    loss of function
in vitro    293T cells and SH-SY5Y cells
in vivo    -
Interaction
Target    miR-150-5p
Type    circRNA-miRNA
Sample    293T cells and SH-SY5Y cells
Experiment    luciferase reporter assay, RIP
Description    RNA immunoprecipitation and luciferase reporter assays demonstrated that cir-ZNF609 may act as a sponge for miR-150-5p to modulate the expression of AKT3.
ceRNA target    AKT3
Reference
Pubmed ID    27903978
Trait/Disease    Hirschsprungs Disease
Title    Circular RNA ZNF609 functions as a competitive endogenous RNA to regulate AKT3 expression by sponging miR-150-5p in Hirschsprungs disease.
Authors    Peng L, Chen G, Zhu Z, Shen Z, Du C, Zang R, Su Y, Xie H, Li H, Xu X, Xia Y, Tang W.
Journal    Oncotarget. 2017