RefCirc
a reference database for circRNAs validated by experiments

circPVT1 Details
Basic Information
circRNA    circPVT1
Alias    -
circBase ID    -
Host gene    PVT1
Species    homo sapiens
Peptide    -
Sequence  -
Expression
Description  upregulated in GC
Method    RNA-seq, qRT-PCR
Sample    paired cancer specimens and adjacent normal tissues, MGC-803 and AGS
Function
Description  circPVT1 may promote cell proliferation by acting as a sponge for members of the miR-125 family. The level of circPVT1 was observed as an independent prognostic marker for overall survival and disease-free survival of patients with GC.
Method    loss of function
in vitro    MGC-803 and AGS
in vivo    -
Interaction
Target    miR-125a, miR-125b and let-7b
Type    circRNA-miRNA
Sample    HEK-293T
Experiment    luciferase reporter assay
Description    Compared with the control RNA, miR-125a, miR-125b and let-7b reduced the luciferase reporter activity by at least 25%.
ceRNA target    E2F2
Reference
Pubmed ID    27986464
Trait/Disease    Gastric Cancer
Title    Circular RNA profile identifies circPVT1 as a proliferative factor and prognostic marker in gastric cancer.
Authors    Chen J, Li Y, Zheng Q, Bao C, He J, Chen B, Lyu D, Zheng B, Xu Y, Long Z, Zhou Y, Zhu H, Wang Y, He X, Shi Y, Huang S.
Journal    Cancer Lett. 2017