RefCirc
a reference database for circRNAs validated by experiments
| hsa_circ_0124644 Details |
| Basic Information |
| circRNA | hsa_circ_0124644 |
| Alias | - |
| circBase ID | hsa_circ_0124644 |
| Host gene | ROBO2 |
| Species | homo sapiens |
| Peptide | - |
| Sequence | GGAAGGAAAAGCTTCTTCAGAATCTCCAGAAGATTTTCACTTGTATCTCACCGGCCAGAACTGTGTCACATATCAACACATACCTGTGAATGGAGCTGGAAAAGCACGTATTACTTGGACACATTATTGTCAGAACACAGGAAGGATTATGATGCCATAGAAAAGGGGTGAGTGGTTATTTAGTAGGAACTTCAGGGGCTGGACAGGAGATTTGAAGCAGGAAAGTGAGTTCAGCAATGTTATATGCCATAGTGCTCATTACATCATCTGGATTTTCCAGAGCCAGGGTAATTAGTTTTCAGATTAAAATTAGTTTTCAGATTATTTCTTTAAAATGAAGTATATTTGCAAAAATAAAATCATTAAATAGTAAAAAATGTCAATACTGAAAGAGACCTGCTGTTAGAGGCCACACTGTCTATTGCAATGTGGGGCTGCCTCTCAGCCAATGAGAAGTATAACCAGACCACTTCCTTCTGCCAACAGCTCTTCTGAGGACATGGGATAGCAAAGGCTGCAGATCTCAACACAACTTTAGAGGTAGGATTTTGAGGATAAAGAAAACAAGTAAAGAAAGGGGAGGGAGAGAGACACGTGGAGAGAAAGAGACATGGAGAGAGAGGACTAAGGAAAGTGGCTGAGGCCTGCCCCTCTTCCAAACACTTGTCCTTTTCTTTTTCTTTTCTTTTTTTTTTTGAGATAGAGTCTCACTCTGTCGCGCCAAGCTGGAGTGCAGTGGCACAATCTCAGCTCACTGCAACCTCTGCCTCCTTGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTAGAGGTCCGCACCACCCTGCCAAGCTTATTTTTGTATTTTTAGCAGACACGGGGTTTCACCATGTTGGCCAGGATGGTCTTGATCCCTTGACCTTGTGATCCTCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACTGCGTCCAGCATGTCCTATTCTCATATTCAGAAAAAGGCTAGGCTCAGCTAAGAAAAGATAAGAAGACATTATTTAAACTAGTAGTAATTTGTTTGGCCAATTTCCAAGTTAATTACTACTTGACCCTACTGAAAACTGCCTTTTGGATTTGGTTATAGAATGCCTTGGAGTTATGGAGACAGAAGTCAGAATACAGCAGGTTGAGAAGTAACTCGTCAAG |
| Expression |
| Description | We verified the 5 candidate biomarkers by qPCR in another independent cohort consisting of 30 control subjects (CADS = 0, n = 30) and 30 CAD patients with different CADS (CADS 1-22, n = 10; CADS 23-32, n = 10; CADS > 33, n = 10). The results confirmed the findings of the microarray analysis, as the levels of these 5 circRNAs were significantly increased in the CAD patients; there was a 2.7-fold change in the expression of hsa_circ_0124644, and 2.2-, 2.1-, 2.0-, and 2.1-fold changes in the expression levels of hsa_circ_0082081, hsa_circ_0113854, hsa_circ_0098964 and hsa-circRNA5974-1,respectively. hsa_circ_0124644 can be used as a diagnostic biomarker of CAD. |
| Method | qRT-PCR, microarray |
| Sample | peripheral blood from 12 CAD patients and 12 controls |
| Reference |
| Pubmed ID | 28045102 |
| Trait/Disease | Coronary Artery Disease |
| Title | Peripheral blood circular RNA hsa_circ_0124644 can be used as a diagnostic biomarker of coronary artery disease. |
| Authors | Zhao Z, Li X, Gao C, Jian D, Hao P, Rao L, Li M. |
| Journal | Sci Rep. 2017 |