RefCirc
a reference database for circRNAs validated by experiments

Circ100284 Details
Basic Information
circRNA    Circ100284
Alias    -
circBase ID    -
Host gene    -
Species    homo sapiens
Peptide    -
Sequence  -
Expression
Description  increased by arsenite in HaCaT cells
Method    qRT-PCR
Sample    HaCaT, arsenite-treated HaCaT (As-HaCaT) cells and in arsenite-transformed (T-HaCaT) cells
Function
Description  Knockdown of circ100284 with siRNA inhibited the capacity of T-HaCaT cells for colony formation, invasion, and migration, effects that were reversed by co-transfection with a miR-217 inhibitor or by epigenetic expression of EZH2.
Method    loss of function
in vitro    HaCaT, T-HaCaT
in vivo    -
Interaction
Target    miR-217
Type    circRNA-miRNA
Sample    HaCaT, T-HaCaT
Experiment    expression and function
Description    Flow cytometry was performed and showed that inhibited G1/S transition was observed in As-HaCaT cells transfected with circ100284 siRNA, but co-transfected with miR-217 inhibitor restored the inhibition
ceRNA target    EZH2
Reference
Pubmed ID    28062277
Trait/Disease    Keratinocyte Carcinogenesis
Title    Circ100284, via miR-217 regulation of EZH2, is involved in the arsenite-accelerated cell cycle of human keratinocytes in carcinogenesis.
Authors    Xue J, Liu Y, Luo F, Lu X, Xu H, Liu X, Lu L, Yang Q, Chen C, Fan W, Liu Q.
Journal    Biochim Biophys Acta. 2017