RefCirc
a reference database for circRNAs validated by experiments

circHIAT1 Details
Basic Information
circRNA    circHIAT1
Alias    -
circBase ID    -
Host gene    HIAT1
Species    homo sapiens
Peptide    -
Sequence  -
Expression
Description  lower in ccRCCs
Method    qRT-PCR
Sample    ccRCCs and adjacent normal tissues, OSRC-2, SW839, ACHN
Function
Description  AR promotes metastasis of ccRCC via circHIAT1. AR enhances ccRCC cell migration and invasion via altering circHIAT1 expression. Lower circHIAT1 expression led to a worse prognosis in ccRCC patients.
Method    loss of function, gain of function
in vitro    OSRC-2, SW839, ACHN
in vivo    6-8 weeks old nude mice
Interaction
Target    miR-195-5p/29a-3p/29c-3p
Type    circRNA-miRNA
Sample    OSRC-2
Experiment    RNA pull-down
Description    overexpressed circHIAT1 absorbed more miR-195-5p/29a-3p/29c-3p compared with the control in SW-839 cells, while shcircHIAT1 in OSRC2 cells absorbed less miR-195-5p/29a-3p/29c-3p
ceRNA target    CDC42
Reference
Pubmed ID    28089832
Trait/Disease    Clear Cell Renal Cell Carcinoma
Title    Androgen receptor (AR) promotes clear cell renal cell carcinoma (ccRCC) migration and invasion via altering the circHIAT1/miR-195-5p/29a-3p/29c-3p/CDC42 signals.
Authors    Wang K, Sun Y, Tao W, Fei X, Chang C.
Journal    Cancer Lett. 2017