RefCirc
a reference database for circRNAs validated by experiments

circ-TTBK2 Details
Basic Information
circRNA    circ-TTBK2
Alias    -
circBase ID    -
Host gene    TTBK2
Species    homo sapiens
Peptide    -
Sequence  -
Expression
Description  upregulated in glioma
Method    FISH, qRT-PCR
Sample    NBTs (normal brain tissues) (n = 11), grade I (n = 19), grade II (n = 19), grade III (n = 19), grade IV (n = 19) glioma tissues, NHA, U87, and U251 cells
Function
Description  Enhanced expression of circ-TTBK2 promoted cell proliferation, migration, and invasion, while inhibited apoptosis.
Method    -
in vitro    U251, U87
in vivo    nude mice
Interaction
Target    miR-217
Type    circRNA-miRNA
Sample    HEK293T, U87, U251
Experiment    luciferase reports and RNA immunoprecipitation
Description    The luciferase activity in the circ-TTBK2-Wt+miR-217 group was significantly decreased than that in the circ-TTBK2-Wt+miR-217-NC group, while the luciferase activity in the circ-TTBK2-Mut+miR-217 group was not changed. The relative enrichment levels of circ-TTBK2 and miR-217 were both increased in the anti-Ago2 group than those in the anti-normal group.
ceRNA target    HNF1beta
Reference
Pubmed ID    28219405
Trait/Disease    Glioma
Title    TTBK2 circular RNA promotes glioma malignancy by regulating miR-217/HNF1beta/Derlin-1 pathway.
Authors    Zheng J, Liu X, Xue Y, Gong W, Ma J, Xi Z, Que Z, Liu Y.
Journal    J Hematol Oncol. 2017