RefCirc
a reference database for circRNAs validated by experiments

circCCDC66 Details
Basic Information
circRNA    circCCDC66
Alias    hsa_circ_000374
circBase ID    hsa_circ_0001313
Host gene    CCDC66
Species    homo sapiens
Peptide    -
Sequence  GAAACAGTACTGCTGGAGCACCCTTTCAGTGCTGTGAAACAAGAACTGCAAAGAAAATGGATTGAAGAGTTGAATAAGCAAATAGAAGATGACCGTCAAAGAAAAATAGAGGAAAAAATTATATATTCAAAGGGTGAGGAACATGACAGATGGGCAATGCACTTTGATTCATTAAAGAGTTATCCTGGTTCTCAATCTCAGCTGTTCTCTCAGTCAACACACAAACAACCTGAGTACTTCTGTGTCTCTCCTGACACTCAGGAGCTGGCTGATGTCAGCAGTGTTTGTACACCTACAACCGGAAGCCAGGTTGAACCTTCAGAGGAGGAGCATATAGCAAAACCTATTAAGGATGTGGTTATGGCAAACAGTAAGAAAACAAACTTTCTCCGTTCTATGACTGCTCTCTTGGACCCAGCTCAGATTGAGGAACGAGACAGACGACGACAAAAACAATTAGAGCATCAG
Expression
Description  CircCCDC66 expression was elevated in polyps and colon cancer
Method    RNA-seq, qRT-PCR
Sample    polyps, colon cancer
Function
Description  circCCDC66 controlled multiple pathological processes, including cell proliferation, migration, invasion, and anchorage-independent growth. In-depth characterization revealed that circCCDC66 exerts its function via regulation of a subset of oncogenes, and knockdown of circCCDC66 inhibited tumor growth and cancer invasion in xenograft and orthotopic mouse models, respectively.
Method    loss of function, gain of function, mouse model
in vitro    HCT116, HT-29, 3T3L1
in vivo    -
Interaction
Target    -
Type    -
Sample    -
Experiment    -
Description    -
ceRNA target    -
Reference
Pubmed ID    28249903
Trait/Disease    Colorectal Cancer
Title    Noncoding Effects of Circular RNA CCDC66 Promote Colon Cancer Growth and Metastasis.
Authors    Hsiao KY, Lin YC, Gupta SK, Chang N, Yen L, Sun HS, Tsai SJ.
Journal    Cancer Res. 2017