RefCirc
a reference database for circRNAs validated by experiments

circRNA_100290 Details
Basic Information
circRNA    circRNA_100290
Alias    -
circBase ID    -
Host gene    SLC30A7
Species    homo sapiens
Peptide    -
Sequence  -
Expression
Description  The expression of circRNA_100290 in OSCC was upregulated by nearly sevenfold.
Method    microarray, qRT-PCR
Sample    Tissue samples of OSCC and paired NCMT, SCC9, CAL27, HN4 and Human oral keratinocytes
Function
Description  Silencing of circRNA_100290 induced G1/S arrest in SCC9 cell lines. Cell proliferation was significantly reduced in the circRNA_100290 knockdown group. Silencing of circRNA_100290 markedly decreased the growth of the tumours in vivo.
Method    loss of function
in vitro    SCC9, CAL27, HN4
in vivo    BALB/C-nu/nu, female and 5-week-old
Interaction
Target    miR-29b
Type    circRNA-miRNA
Sample    Tissue samples of OSCC and paired NCMT, HEK293T
Experiment    circRNA microarray data and mRNA microarray data, luciferase reporter assay
Description    miR-29b-3p, miR-29c-3p and miR-29a-3p were the top three predicted miRNA targets of circRNA_100290.. Co-transfection of luciferase reporters containing a 3UTR sequence and miR-29b mimics into 293T cells reduced over 60% of the luciferase intensity.
ceRNA target    CDK6
Reference
Pubmed ID    28368401
Trait/Disease    Oral Squamous Cell Carcinoma
Title    circRNA_100290 plays a role in oral cancer by functioning as a sponge of the miR-29 family.
Authors    Chen L, Zhang S, Wu J, Cui J, Zhong L, Zeng L, Ge S.
Journal    Oncogene. 2017