RefCirc
a reference database for circRNAs validated by experiments

has_circ_0016347 Details
Basic Information
circRNA    has_circ_0016347
Alias    -
circBase ID    hsa_circ_0016347
Host gene    KCNH1
Species    homo sapiens
Peptide    -
Sequence  GTCCTACAGCTGGGCTCAGACATCCTTCCCCAGTACAAGCAAGAGGCACCAAAGACTCCCCCTCACATCATCTTACATTATTGTGTTTTTAAGACCACGTGGGATTGGATCATCTTGATCTTGACCTTCTATACAGCCATCTTGGTCCCTTATAATGTCTCCTTCAAAACCAGGCAGAATAATGTGGCCTGGCTGGTTGTTGATAGCATCGTGGATGTTATCTTTTTGGTGGACATTGTGCTCAATTTTCATACCACCTTTGTTGGACCAGCAGGGGAGGTGATTTCTGACCCCAAACTTATCCGCATGAACTACCTGAAGACGTGGTTTGTGATTGACCTTCTGTCCTGTTTGCCATATGATGTCATCAACGCTTTTGAGAACGTGGATGAGGTTAGTGCCTTTATGGGTGATCCAGGGAAGATTGGTTTTGCTGATCAGATTCCACCACCACTGGAGGGGAGAGAGAGTCAGGGCATCAGCAGCCTGTTCAGCTCTCTAAAAGTTGTCCGGCTGCTCCGTCTTGGGCGAGTGGCCCGTAAGCTGGACCACTACATTGAATATGGAGCTGCTGTGCTGGTCCTGCTGGTGTGTGTGTTTGGGCTGGCTGCACACTGGATGGCCTGCATCTGGTACAGCATTGGGGACTATGAGATCTTTGACGAGGACACCAAGACAATCCGCAACAACAGCTGGCTGTACCAACTAGCGATGGACATTGGCACCCCTTACCAGTTTAATGGGTCTGGCTCAGGGAAGTGGGAAGGTGGTCCCAGCAAGAATTCTGTCTACATCTCCTCGTTGTATTTCACAATGACCAGCCTCACCAGTGTGGGCTTTGGGAACATCGCCCCATCCACAGACATTGAGAAGATCTTTGCAGTGGCCATCATGATGATTGGCT
Expression
Description  circ-0016347 levels are elevated in osteosarcoma
Method    qRT-PCR
Sample    OS tissues and adjacent non-tumor tissues, hFOB, MG63, Saos-2
Function
Description  circ-0016347 promotes the proliferation, invasion and metastasis of osteosarcoma cells. circ-0016347 promotes caspase-1 expression and cell proliferation in osteosarcoma.
Method    loss of function
in vitro    MG63, Saos-2
in vivo    Male BALB/c mice, 5 to 6 weeks old
Interaction
Target    miR-214
Type    circRNA-miRNA
Sample    MG63, Saos-2
Experiment    expression
Description    The circ-0016347 expression level was partly increased when miR-214 was inhibited compared to ells merely transfected with si-circRNA. Furthermore, circ-0016347 is positively orrelated with caspase-1, which could be reversed by iR-214 inhibitor. Collectively, these data illustrate that irc-0016347 negatively correlates with miR-214 and ndirectly influences the expression of caspase-1 in the steosarcoma cells.
ceRNA target    Caspase-1
Reference
Pubmed ID    28424426
Trait/Disease    Osteosarcoma
Title    Circular RNA hsa-circ-0016347 promotes proliferation, invasion and metastasis of osteosarcoma cells.
Authors    Jin H, Jin X, Zhang H, Wang W.
Journal    Oncotarget. 2017