RefCirc
a reference database for circRNAs validated by experiments

circ-Amotl1 Details
Basic Information
circRNA    circ-Amotl1
Alias    hsa_circ_0004214
circBase ID    -
Host gene    Amotl1
Species    homo sapiens
Peptide    -
Sequence  -
Expression
Description  highly expressed in patient tumor samples and cancer cell lines
Method    qRT-PCR
Sample    specimens of patients with breast carcinoma, HaCaT, MCF-10A, MCF-7, SK-Br-3, HTB-126, MB-468, MB-231, H460, HeLa, JHH-1, U87
Function
Description  Circ-Amotl1 increased cell survival and colony formation. Expression of circ-Amotl1 increased cell proliferation. Expression of circ-Amotl1 enhanced tumor formation. circ-Amotl1 promoted nuclear translocation of c-myc.
Method    loss of function, gain of function
in vitro    MDA-MB-231, SK-BR-3
in vivo    nude mice xenografts
Interaction
Target    c-myc
Type    circRNA-protein
Sample    MDA-MB-231
Experiment    RNA immunoprecipitation
Description    It was noted that c-myc showed the greatest binding capacity to circ-Amotl1, suggesting a critical role of c-myc in mediating circ-Amotl1 functions.
ceRNA target    -
Reference
Pubmed ID    28622299
Trait/Disease    Tumorigenesis
Title    A circular RNA promotes tumorigenesis by inducing c-myc nuclear translocation.
Authors    Yang Q, Du WW, Wu N, Yang W, Awan FM, Fang L, Ma J, Li X, Zeng Y, Yang Z, Dong J, Khorshidi A, Yang BB.
Journal    Cell Death Differ. 2017