RefCirc
a reference database for circRNAs validated by experiments

circRNAs-MSR Details
Basic Information
circRNA    circRNAs-MSR
Alias    circRNA_100226
circBase ID    -
Host gene    MSR
Species    homo sapiens
Peptide    -
Sequence  -
Expression
Description  overexpressed in the damaged region compared with the intact region of the cartilage in OA
Method    microarray, qRT-PCR
Sample    the damaged region and the intact region of the cartilage in OA
Function
Description  circRNAs-MSR were silenced using small interfering RNA, and knockdown of circRNAs-MSR could suppress tumor necrosis factor alpha (TNF-alpha) expression and increase extracellular matrix (ECM) formation. Our results demonstrated that circRNAs-MSR regulated TNF-alpha expression and participated in the chondrocyte ECM degradation process
Method    loss of function
in vitro    Chondrocyte
in vivo    -
Interaction
Target    miR-875
Type    circRNA-miRNA
Sample    -
Experiment    predicted
Description    The circRNA-MSR 3UTR sequence matched these miRNAs, and the TNF-a 3UTR matched miR-875. Thus, we identified a common miRNA (miR-875) for circRNA-MSR and TNF-alpha targets.
ceRNA target    TNF-alpha
Reference
Pubmed ID    28624198
Trait/Disease    Osteoarthritis
Title    Emerging Roles of circRNA Related to the Mechanical Stress in Human Cartilage Degradation of Osteoarthritis.
Authors    Liu Q, Zhang X, Hu X, Yuan L, Cheng J, Jiang Y, Ao Y.
Journal    Mol Ther Nucleic Acids. 2017