RefCirc
a reference database for circRNAs validated by experiments

CircRNA_100269 Details
Basic Information
circRNA    CircRNA_100269
Alias    -
circBase ID    -
Host gene    -
Species    homo sapiens
Peptide    -
Sequence  -
Expression
Description  CircRNA_100269 is downregulated in gastric cancer
Method    qRT-PCR
Sample    human GC specimens and their adjacent non-cancerous tissue samples
Function
Description  CircRNA_100269 suppressed tumor growth in GC cell lines.
Method    gain of function
in vitro    AGS, MKN28
in vivo    -
Interaction
Target    miR-630
Type    circRNA-miRNA
Sample    AGS and SGC7901 cells
Experiment    luciferase reporter assay
Description    Normalized fluorescence intensity of the reporter was significantly lower in cancer cells cotransfected with the circRNA_100269 segment and miR-630 mimics compared to controls.
ceRNA target    -
Reference
Pubmed ID    28657541
Trait/Disease    Gastric Cancer
Title    CircRNA_100269 is downregulated in gastric cancer and suppresses tumor cell growth by targeting miR-630.
Authors    Zhang Y, Liu H, Li W, Yu J, Li J, Shen Z, Ye G, Qi X, Li G.
Journal    Aging (Albany NY). 2017