RefCirc
a reference database for circRNAs validated by experiments

hsa_circ_0013958 Details
Basic Information
circRNA    hsa_circ_0013958
Alias    -
circBase ID    hsa_circ_0013958
Host gene    ACP6
Species    homo sapiens
Peptide    -
Sequence  GTAGAGTGGAACCCCCAGCTATTAGAGGTCCCACCCCAAACTCAGTTTGATTACACAGTCACCAATCTAGCTGGTGGTCCGAAACCATATTCTCCTTACGACTCTCAATACCATGAGACCACCCTGAAGGGGGGCATGTTTGCTGGGCAGCTGACCAAGGTGGGCATGCAGCAAATGTTTGCCTTGGGAGAGAGACTGAGGAAGAACTATGTGGAAGACATTCCCTTTCTTTCACCAACCTTCAACCCACAGGAGGTCTTTATTCGTTCCACTAACATTTTTCGGAATCTGGAGTCCACCCGTTGTTTGCTGGCTGGGCTTTTCCAGTGTCAGAAAGAAG
Expression
Description  Hsa_circ_0013958 level was up-regulated in LAC
Method    microarray, qRT-PCR, FISH
Sample    primary LAC and noncancer tissues?? plasma samples from LAC patients and healthy volunteers?? A549 and H1299
Function
Description  Knockdown of hsa_circ_0013958 suppressed proliferation in LAC cells. Induction of cell apoptosis was observed after silencing hsa_circ_0013958 in LAC cells. Hsa_circ_0013958 promoted cell migration and invasion in LAC cells.
Method    gain of function, loss of function
in vitro    A549 and H1299
in vivo    -
Interaction
Target    miR-134
Type    circRNA-miRNA
Sample    HEK293T
Experiment    luciferase reporter assay
Description    Compared to the control RNA, only miR-134-5p reduced the luciferase reporter activity by at least 50%.
ceRNA target    CCND1
Reference
Pubmed ID    28685964
Trait/Disease    Lung Adenocarcinoma
Title    hsa_circ_0013958: a circular RNA and potential novel biomarker for lung adenocarcinoma.
Authors    Zhu X, Wang X, Wei S, Chen Y, Chen Y, Fan X, Han S, Wu G.
Journal    FEBS J. 2017