RefCirc
a reference database for circRNAs validated by experiments

cir-GLI2 Details
Basic Information
circRNA    cir-GLI2
Alias    -
circBase ID    -
Host gene    GLI2
Species    homo sapiens
Peptide    -
Sequence  -
Expression
Description  Cir-GLI2 was upregulated in OS
Method    microarray, qRT-PCR
Sample    OS tissues and adjacent non-tumor tissues, hFOB, MG63, Saos-2, HOS, and U2-OS
Function
Description  Cir-GLI2 silencing suppressed the proliferation, migration, and invasion of OS cells
Method    loss of function
in vitro    MG63, Saos-2
in vivo    -
Interaction
Target    miR-125b-5p
Type    circRNA-miRNA
Sample    MG63, Saos-2
Experiment    luciferase reporter assay
Description    In MG63 and Saos-2 cells, dual-luciferase reporter assay showed that the co-transfection of pGL3-cir-GLI2 wild type and miR-125b-5p mimics distinctly decreases the luciferase activity compared to NC group.
ceRNA target    -
Reference
Pubmed ID    28695772
Trait/Disease    Osteosarcoma
Title    Circular RNA GLI2 promotes osteosarcoma cell proliferation, migration, and invasion by targeting miR-125b-5p.
Authors    Li JF, Song YZ.
Journal    Tumour Biol. 2017