RefCirc
a reference database for circRNAs validated by experiments

circRNA_100338 Details
Basic Information
circRNA    circRNA_100338
Alias    hsa_circ_100338
circBase ID    -
Host gene    SNX27
Species    homo sapiens
Peptide    -
Sequence  -
Expression
Description  upregulated in HCC
Method    microarray, qRT-PCR
Sample    HCC tissues and paired pericancerous tissues, Hep3B, BEL7402, MHCC97H and HCCLM6
Function
Description  Expression levels of circRNA_100338 in HCC patients are highly correlated with cancer metastatic progression and, consequently, the cumulative survival rate. circRNA_100338 and miR-141-3p regulate the metastatic potential of liver cancer cells.
Method    gain of function
in vitro    MHCC97H
in vivo    -
Interaction
Target    miR-141-3p
Type    circRNA-miRNA
Sample    HEK293T, HCC tissues
Experiment    luciferase reporter assay, expression
Description    Co-transfection with miR-141-3p mimic or co-transfection with scramble RNA in circRNA_100338-expressing HEK293T cells led to comparable expression of luciferase when the miR-141-3p binding site was mutated in circRNA_100338. The expression of circRNA_100338 was significantly upregulated by approximately 3~4-fold in HCC tissues compared with that in paired pericancerous tissues. In sharp contrast to circRNA_100338, the expression of miR-141-3p in HCC tissues was downregulated compared with that in paired pericancerous tissues by approximately five fold and with high statistical significance (P < 0.001).
ceRNA target    -
Reference
Pubmed ID    28710406
Trait/Disease    Hepatocellular Carcinoma
Title    Comprehensive circular RNA profiling reveals the regulatory role of the circRNA-100338/miR-141-3p pathway in hepatitis B-related hepatocellular carcinoma.
Authors    Huang XY, Huang ZL, Xu YH, Zheng Q, Chen Z, Song W, Zhou J, Tang ZY, Huang XY.
Journal    Sci Rep. 2017