RefCirc
a reference database for circRNAs validated by experiments

circDENND4C Details
Basic Information
circRNA    circDENND4C
Alias    -
circBase ID    -
Host gene    DENND4C
Species    homo sapiens
Peptide    -
Sequence  -
Expression
Description  hypoxia-associated circRNAs in endothelial cells after hypoxia induction
Method    qRT-PCR
Sample    Primary invasive ductal carcinomas of breast and adjacent non-cancerous breast tissues, MCF-7 and MDA-MB-231
Function
Description  CircDENND4C mediates proliferation of breast cancer cells in hypoxic environment. CircDENND4C expression level is positively correlated to HIF1?? level and tumor size in breast cancer patients.
Method    loss of function
in vitro    MDA-MB-231
in vivo    -
Interaction
Target    -
Type    -
Sample    -
Experiment    -
Description    -
ceRNA target    -
Reference
Pubmed ID    28739726
Trait/Disease    Breast Cancer
Title    HIF1?±-associated circDENND4C Promotes Proliferation of Breast Cancer Cells in Hypoxic Environment.
Authors    Liang G, Liu Z, Tan L, Su AN, Jiang WG, Gong C.
Journal    Anticancer Res. 2017