RefCirc
a reference database for circRNAs validated by experiments

circ-ABCB10 Details
Basic Information
circRNA    circ-ABCB10
Alias    -
circBase ID    hsa_circ_0008717
Host gene    ABCB10
Species    homo sapiens
Peptide    -
Sequence  TTTTTTGTCTCACCTAATCTGGCCACCTTTGTTTTGAGCGTGGTGCCTCCAGTGTCAATCATTGCTGTAATTTATGGGCGATATCTACGGAAACTGACCAAAGTCACTCAGGATTCCCTGGCACAAGCCACTCAGCTAGCTGAGGAACGTATTGGAAATGTAAGAACTGTTCGAGCTTTTGGGAAAGAAATGACTGAAATCGAGAAATATGCCAGCAAAGTGGACCATGTAATGCAGTTAGCAAGGAAAGAGGCATTCGCCCGGGCTGGTTTCTTTGGAGCAACTGGGCTCTCCGGAAACCTGATCGTGCTTTCTGTCCTGTACAAAGGAGGGCTGCTGATGGGCAGTGCCCACATGACCGTGGGTGAACTCTCTTCCTTCCTAATGTATGCTTTCTGGGTTGGAATAAGCATTGGAGGTCTGAGCTCTTTCTACTCGGAGCTGATGAAAGGACTGGGTGCAGGGGGGCGCCTCTGGGAGCTCCTGGAGAGAGAGCCCAAGCTGCCTTTTAACGAGGGGGTCATCTTAAATGAGAAAAGCTTCCAGGGTGCTTTGGAGTTTAAGAACGTGCATTTTGCCTATCCAGCTCGCCCAGAGGTGCCCATATTTCAGGATTTCAGCCTTTCCATTCCGTCAGGATCTGTCACGGCACTGGTTGGCCCAAGTGGTTCTGGCAAATCAACAGTGCTTTCACTCCTGCTGAGGTTGTACGACCCTGCTTCTG
Expression
Description  circ-ABCB10 was identified to be significantly up-regulated in breast cancer
Method    microarray, qRT-PCR
Sample    cancer and adjacent noncancerous tissue. MCF-7, MDAMB-231, MDA-MB-468, MDA-MB-453, MCF-10A
Function
Description  Circ-ABCB10 knockdown suppressed breast cancer cells proliferation and enhanced apoptosis.
Method    loss of function
in vitro    MCF-7, MDA-MB-231
in vivo    -
Interaction
Target    miR-1271
Type    circRNA-miRNA
Sample    HEK293T
Experiment    luciferase reporter assay
Description    Luciferase reporter assay showed the luciferase intensity of miR-1271 binding with circ-ABCB10 wild type was decreased.
ceRNA target    -
Reference
Pubmed ID    28744405
Trait/Disease    Breast Cancer
Title    Circular RNA circ-ABCB10 promotes breast cancer proliferation and progression through sponging miR-1271.
Authors    Liang HF, Zhang XZ, Liu BG, Jia GT, Li WL.
Journal    Am J Cancer Res. 2017