RefCirc
a reference database for circRNAs validated by experiments

Circular RNA CDR1as Details
Basic Information
circRNA    Circular RNA CDR1as
Alias    -
circBase ID    -
Host gene    CDR1
Species    homo sapiens
Peptide    -
Sequence  -
Expression
Description  CDR1as was downregulated in HCC
Method    microarray, qRT-PCR
Sample    HepG2, Huh7, THLE-3, MCF-7, HeLa, HEK293T, HCC tissues and adjacent liver tissues
Function
Description  The CCK-8 assay showed that cell growth was significantly increased after CDR1as overexpression. A lower cell migration capacity of HepG2 cells was observed after CDR1as overexpression, whereas the cell invasion ability was unaffected. Meanwhile, overexpression of CDR1as in HCC cells resulted in enhanced cell adhesion to fibronectin and promoted G1/S phase transition.
Method    gain of function
in vitro    HepG2
in vivo    -
Interaction
Target    miR-7
Type    circRNA-miRNA
Sample    HepG2
Experiment    expression
Description    miR-7 was significantly downregulated after CDR1as overexpression
ceRNA target    EGFR
Reference
Pubmed ID    28892615
Trait/Disease    Hepatocellular Carcinoma
Title    Quantitative Proteomics Reveals the Regulatory Networks of Circular RNA CDR1as in Hepatocellular Carcinoma Cells.
Authors    Yang X, Xiong Q, Wu Y, Li S, Ge F.
Journal    J Proteome Res. 2017