RefCirc
a reference database for circRNAs validated by experiments

Circular RNA_LARP4 Details
Basic Information
circRNA    Circular RNA_LARP4
Alias    hsa_circ_101057
circBase ID    -
Host gene    -
Species    homo sapiens
Peptide    -
Sequence  -
Expression
Description  downregulated in GC
Method    microarray, qRT-PCR, FISH
Sample    GES-1, SGC-7901, MKN-45, MKN-28, HGC-27, MGC-803, AGS, BGC-823, GC patients and adjacent normal tissues
Function
Description  Ectopic expression of circLARP4 inhibited cell growth and colony-forming capacity of GC cells, while knockdown of circLARP4 reversed these effects. The proliferation of HGC-27 cells was impaired by transfection with circLARP4 overexpression vector, but was strengthened by knockdown of circLARP4. Cell invasive potential was weakened by circLARP4 overexpression, but was enhanced by knockdown of circLARP4. circLARP4 Acts as an independent prognostic factor for OS of GC patients.
Method    gain of function, loss of function
in vitro    HGC-27 and MKN-28 cells
in vivo    -
Interaction
Target    miR-424-5p
Type    circRNA-miRNA
Sample    HEK293T, HGC-27 and MKN-28 cells
Experiment    luciferase reporter assay, AGO3 RIP
Description    Compared with the negative control (NC), miR-424 lowered the luciferase reporter activity by approximately 75%, indicating that miR-424 might have the greater potential to bind to circLARP4. circLARP4 and miR-424 were highly expressed in the AGO2 pellet compared with those in the input control.
ceRNA target    LATS1
Reference
Pubmed ID    28893265
Trait/Disease    Gastric Cancer
Title    Circular RNA_LARP4 inhibits cell proliferation and invasion of gastric cancer by sponging miR-424-5p and regulating LATS1 expression.
Authors    Zhang J, Liu H, Hou L, Wang G, Zhang R, Huang Y, Chen X, Zhu J.
Journal    Mol Cancer. 2017