RefCirc
a reference database for circRNAs validated by experiments

Circ-FBXW7 Details
Basic Information
circRNA    Circ-FBXW7
Alias    -
circBase ID    -
Host gene    FBXW7
Species    homo sapiens
Peptide    -
Sequence  -
Expression
Description  Circ-FBXW7 is abundantly expressed in the normal human brain
Method    RNA-seq, northern blots, sanger sequencing
Sample    pathologically diagnosed glioblastoma samples and their paired adjacent normal brain tissues, U251, U373 HS683, SW1783, HEK293T
Function
Description  The spanning junction open reading frame in circ-FBXW7 driven by internal ribosome entry site encodes a novel 21-kDa protein, which we termed FBXW7-185aa. Upregulation of FBXW7-185aa in cancer cells inhibited proliferation and cell cycle acceleration, while knockdown of FBXW7-185aa promoted malignant phenotypes invitro and invivo. FBXW7-185aa reduced the half-life of c-Myc by antagonizing USP28-induced c-Myc stabilization. Moreover, circ-FBXW7 and FBXW7-185aa levels were reduced in glioblastoma clinical samples compared with their paired tumor-adjacent tissues (P < .001). Circ-FBXW7 expression positively associated with glioblastoma patient overall survival (P = .03).
Method    loss of function, gain of function
in vitro    U251, U373 HS683, SW1783, HEK293T
in vivo    Four-week-old female BALB/c-nu mice
Interaction
Target    -
Type    -
Sample    -
Experiment    -
Description    -
ceRNA target    -
Reference
Pubmed ID    28903484
Trait/Disease    Glioma
Title    Novel Role of FBXW7 Circular RNA in Repressing Glioma Tumorigenesis.
Authors    Yang Y, Gao X, Zhang M, Yan S, Sun C, Xiao F, Huang N, Yang X, Zhao K, Zhou H, Huang S, Xie B, Zhang N.
Journal    J Natl Cancer Inst. 2018