RefCirc
a reference database for circRNAs validated by experiments

hsa_circ_0001982 Details
Basic Information
circRNA    hsa_circ_0001982
Alias    -
circBase ID    hsa_circ_0001982
Host gene    RNF111
Species    homo sapiens
Peptide    -
Sequence  GCTTTCCTTAAAGTTTCCCATGTCTCAATGGACTCCTGAATATAACGAGCTCTACACCTTAAAAGTGGATATGAAGAGTGAGATTCCTTCTGATGCACCAAAGACACAGGAGAGTCTGAAAGGGATCCTTTTGCATCCAGAGCCCATTGGGGCAGCCAAAAGTTTTCCTGCAGGAGTTGAGATGATTAATAGTAAAGTGGGGAATGAATTCTCTCACCTGTGTGATGATTCTCAAAAGCAAGAGAAGGAAATGAATGGTAACCAGCAAGAACAAGAAAAAAGTCTCGTTGTGAGGAAAAAACGCAAAAGCCAGCAGGCTGGCCCTTCGTATGTGCAGAATTGTGTTAAAGAAAACCAGGGAATATTAGGACTGAGGCAACACCTAGGGACACCAAGTGATGAAGATAATGATTCCTCTTTTAGTGATTGTCTTTCTTCTCCTTCATCTAGTCTGCATTTTGGAGATTCTGATACTGTGACTTCAGATGAGGATAAAGAAGTCTCTGTAAGACATTCCCAGACCATTTTGAATGCTAAAAGTAGAAGCCATAGTGCACGGTCTCATAAGTGGCCTCGGACTGAGACAGAATCTGTATCGGGATTGTTAATGAAAAGACCCTGTTTACATGGCAGTTCGTTACGGAGACTTCCATGCAGAAAGAGATTTGTAAAAAATAATTCCTCACAGAGGACACAGAAACAAAAAGAGAGGATATTAATGCAGAGGAAGAAACGAGAAGTGTTAGCTCGAAGAAAATATGCCTTGCTACCTAGTTCTAGTAGTTCCAGTGAGAATGACCTCAGCAGTGAATCCTCTTCTAGCTCATCAACTGAAGGAGAAGAAGATTTGTTTGTTTCTGCCAGTGAAAACCACCAAAACAATCCAGCTGTTCCCTCAG
Expression
Description  hsa_circ_0001982 was markedly overexpressed in breast cancer tissue and cell lines
Method    microarray, qRT-PCR
Sample    breast cancer tissues and adjacent normal tissues, HBL-100, MDA-MB-231, MCF-7, MDAMB-468, MDA-MB-435s
Function
Description  hsa_circ_0001982 knockdown suppressed breastcancer cell proliferation and invasion and induced apoptosis by targeting miR-143.
Method    loss of function
in vitro    MCF7
in vivo    -
Interaction
Target    miR-143
Type    circRNA-miRNA
Sample    MCF7
Experiment    luciferase reporter assay
Description    Bioinformatics analysis predicted that miR-143 acted as target of hsa_circ_0001982, which was confirmed by Dual-luciferase reporter assay.
ceRNA target    -
Reference
Pubmed ID    28933584
Trait/Disease    Breast Cancer
Title    Circular RNA hsa_circ_0001982 Promotes Breast Cancer Cell Carcinogenesis Through Decreasing miR-143.
Authors    Tang YY, Zhao P, Zou TN, Duan JJ, Zhi R, Yang SY, Yang DC, Wang XL.
Journal    DNA Cell Biol. 2017