RefCirc
a reference database for circRNAs validated by experiments

hsa_circ_0004018 Details
Basic Information
circRNA    hsa_circ_0004018
Alias    -
circBase ID    hsa_circ_0004018
Host gene    SMYD4
Species    homo sapiens
Peptide    -
Sequence  ACGTGTCTTAAAGACATTAACAGAGCACAGACACATGGGTATCCAGAAAGGTTGCAACCCAAGATTATGTTACGTAAAGCAGAATGTCTGGTGGCCCTGGGGAGACTGCAGGAGGCAAGCCAGACCATCAGTGATCTTGAAAGGAACTTCACAGCCACACCAGCCCTAGCAGATGTCCTCCCTCAGACTCTGCAGAGAAACCTCCATCGTCTGAAAATGAAGATGCAAGAAAAGGACAGTCTCACAGAAAGCTTCCCAGCAGCTCTGGCCAAAACCCTTGAGGATGCAGCGCTGAGGGAGGAGAATGAACAACTTTCCAATGCCTCATCATCCATCGGCTTATGCGTAGATCCTTTAAAAGGTCGCTGTCTCGTTGCCACAAAAGATATTCTCCCAGGAGAGCTCCTGGTGCAGGAGGATGCTTTTGTGAGTGTTCTCAACCCAGGAGAACTGCCACCACCGCATCACGGCCTAGACAGCAAATGGGACACCAGAGTCACCAATGGGGACCTCTATTGTCACCGATGTTTGAAGCACACTTTGGCCACAGTTCCGTGTGACGGATGCAGTTATGCCAAGTATTGCAGCCAGGAGTGTTTGCAGCAGGCCTGGGAGCTCTACCACAGGACAGAATGTCCTCTGGGAGGGCTGCTTCTCACACTGGGTGTCTTTTGCCACATTGCCCTGAGGTTGACTCTTTTGGTGGGATTTGAGGATGTTCGCAAAATCATAACGAAGCTTTGTGATAAGATTAGTAACAAGGACATCTGTTTACCTGAAAGCAACAATCAGGTCAAGACACTTAATTATGGCCTAGGGGAGAGTGAGAAAAATGGCAACATCGTTGAGACCCCAATTCCTGGATGCGATATTAATGGGAAGTATGAAAATAATTATAATGCTGTCTTCAACCTTTTGCCCCACACTGAAAACCATAGCCCAGAGCACAAATTCCTCTGTGCTCTCTGTGTTTCTGCACTGTGCAGACAGCTAGAAGCAGCCAGTTTACAGGCCATCCCAACTGAGAGGATTGTGAACTCCTCTCAGCTTAAAGCAGCAGTGACACCTGAATTGTGTCCTGACGTGACTATTTGGGGAGTGGCGATGCTGAGACACATGTTACAGCTTCAGTGTAACGCTCAGGCGATGACCACCATACAACACACAG
Expression
Description  downregulated in HCC
Method    microarray, qRT-PCR
Sample    HCC tissues and para-tumorous tissues, HepG2, Huh7, SMMC-7721, MHCC97H, HCCLM3, L02
Function
Description  hsa_circ_0004018 level was correlated with serum alpha-fetoprotein (AFP) level, tumor diameters, differentiation, Barcelona Clinic Liver Cancer (BCLC) stage and Tumor-node-metastasis (TNM) stage. The area under the ROC curve (AUC) was 0.848 (95% CI=0.803-0.894, P<0.001).
Method    -
in vitro    -
in vivo    -
Interaction
Target    hsa-miR-30e-5p, hsa-miR-647, hsa-miR-92a-1-5p, hsa-miR-660-3p and hsamiR-626
Type    circRNA-miRNA
Sample    -
Experiment    predicted
Description    -
ceRNA target    MYC
Reference
Pubmed ID    28938566
Trait/Disease    Hepatocellular Carcinoma
Title    Screening differential circular RNA expression profiles reveals hsa_circ_0004018 is associated with hepatocellular carcinoma.
Authors    Fu L, Yao T, Chen Q, Mo X, Hu Y, Guo J.
Journal    Oncotarget. 2017