RefCirc
a reference database for circRNAs validated by experiments

hsa_circ_0043256 Details
Basic Information
circRNA    hsa_circ_0043256
Alias    -
circBase ID    hsa_circ_0043256
Host gene    ACACA
Species    homo sapiens
Peptide    -
Sequence  AAACATGGTGGTGGCTTTGAAGGAGCTGTCTATTCGGGGTGACTTTCGAACTACAGTTGAATACCTGATCAAATTGTTAGAGACTGAAAGCTTTCAGATGAACAGAATTGATACTGGCTGGCTGGACAGACTGATAGCAGAAAAAGTACAGGCTGAGCGACCTGACACCATGTTGGGGGTTGTGTGTGGTGCCCTCCACGTGGCAGATGTGAGCCTGCGGAATAGCGTCTCTAACTTCCTTCACTCCTTAGAAAGGGGTCAAGTCCTTCCTGCTCATACACTTCTGAATACAGTAGATGTTGAACTTATCTATGAGGGAGTCAAGTATGTACTTAAGGTGACTCGACAGTCCCCCAACTCCTATGTGGTGATCATGAATGGCTCATGTGTAGAAGTAGATGTACATCGGCTGAGTGACGGTGGACTGCTCTTGTCCTATGATGGCAGCAGTTATACTACGTATATGAAAGAGGAAGTGGATAG
Expression
Description  hsa_circ_0043256 was upregulated in NSCLC cells in response to cinnamaldehyde treatment
Method    microarray, qRT-PCR
Sample    NCI-H460 and A549
Function
Description  Hsa_circ_0043256 could inhibit cell proliferation and induce apoptosis. hsa_circ_0043256 knock-down could weaken Wnt/??-catenin pathway inhibition induced by CA.
Method    loss of function, gain of function
in vitro    NCI-H460 and A549
in vivo    Male BALB/c nude mice
Interaction
Target    miR-1252
Type    circRNA-miRNA
Sample    NCI-H460 and A549
Experiment    luciferase reporter assay, Ago2 RIP
Description    The luciferase activity markedly decreased upon the combination of hsa_circ_0043256 and miR-1252. Flag-Ago2 RIP results confirmed that hsa_circ_0043256 could bind miR-1252 to work as miRNA sponge.
ceRNA target    ITCH
Reference
Pubmed ID    28958934
Trait/Disease    Non-Small Cell Lung Cancer
Title    Cinnamaldehyde induces cell apoptosis mediated by a novel circular RNA hsa_circ_0043256 in non-small cell lung cancer.
Authors    Tian F, Yu CT, Ye WD, Wang Q.
Journal    Biochem Biophys Res Commun. 2017