RefCirc
a reference database for circRNAs validated by experiments

circUBAP2 Details
Basic Information
circRNA    circUBAP2
Alias    -
circBase ID    -
Host gene    UBAP2
Species    homo sapiens
Peptide    -
Sequence  -
Expression
Description  increased in osteosarcoma
Method    microarray, qRT-PCR
Sample    Human osteosarcoma tumor tissues and matched adjacent normal tissues, hFOB, MG63 and U2OS
Function
Description  Increased circUBAP2 expression is significantly correlated with the progression and prognosis of osteosarcoma patients. CircUBAP2 promotes osteosarcoma growth both in vitro and in vivo. CircUBAP2 inhibits osteosarcoma cell apoptosis by upregulating the expression of anti-apoptotic Bcl-2.
Method    gain of function
in vitro    MG63, U2OS
in vivo    BALB/c athymic nude mice
Interaction
Target    miR-143
Type    circRNA-miRNA
Sample    MG63
Experiment    RIP
Description    We found a specific enrichment of miR-143 in the precipitates of circUBAP2, suggesting that miR-143 is the circUBAP2-associated miRNA in osteosarcoma cells.
ceRNA target    Bcl-2
Reference
Pubmed ID    28977896
Trait/Disease    Osteosarcoma
Title    Increased circular RNA UBAP2 acts as a sponge of miR-143 to promote osteosarcoma progression.
Authors    Zhang H, Wang G, Ding C, Liu P, Wang R, Ding W, Tong D, Wu D, Li C, Wei Q, Zhang X, Li D, Liu P, Cui H, Tang H, Ji F.
Journal    Oncotarget. 2017