RefCirc
a reference database for circRNAs validated by experiments

circRNA_0046367 Details
Basic Information
circRNA    circRNA_0046367
Alias    -
circBase ID    -
Host gene    -
Species    homo sapiens
Peptide    -
Sequence  -
Expression
Description  Cells with high-fat-induced steatosis (steatosis group) were characterized by the expression loss of circRNA_0046367 in comparison to those in the normal group.
Method    qRT-PCR
Sample    HepG2
Function
Description  We uncover circRNA_0046367 to be endogenous modulator of miR-34a that underlies hepatic steatosis. In contrast to its expression loss during the hepatocellular steatosis in vivo and in vitro, circRNA_0046367 normalization abolished miR-34a inhibitory effect on peroxisome proliferator-activated receptor ?? (PPAR??) via blocking the miRNA/mRNA interaction with miRNA response elements (MREs).
Method    gain of function
in vitro    HepG2 cells
in vivo    Liver tissues of patients with hepatic steatosis
Interaction
Target    miR-34a
Type    circRNA-miRNA
Sample    HepG2 cells
Experiment    luciferase reporter assay
Description    These demonstrations provided substantial evidence for a direct, high-affinitive targeting of miR-34a by circRNA_0046367.
ceRNA target    PPAR??
Reference
Pubmed ID    29018509
Trait/Disease    Hepatic Steatosis
Title    circRNA_0046367 Prevents Hepatoxicity of Lipid Peroxidation: An Inhibitory Role against Hepatic Steatosis.
Authors    Guo XY, Chen JN, Sun F, Wang YQ, Pan Q, Fan JG.
Journal    Oxid Med Cell Longev. 2017