RefCirc
a reference database for circRNAs validated by experiments

circGFRA1 Details
Basic Information
circRNA    circGFRA1
Alias    -
circBase ID    -
Host gene    GFRA1
Species    homo sapiens
Peptide    -
Sequence  -
Expression
Description  circGFRA1 was upregulated especially in TNBC cell lines (including BT-20, BT549, MDA-MB-468 and MDA-MB-231).
Method    microarray, qRT-PCR
Sample    Tumor and paired adjacent normal mammal tissues from TNBC patients. HCC adjacent normal tissues, SKBR3, T47D, BT474, MCF-7, BT-483, BT-20, BT549, MDA-MB-468, MDA-MB-231, MCF10A and 184A1
Function
Description  circGFRA1 correlated with poor clinical outcomes in TNBC. Knockdown of circGFRA1 inhibits proliferation and promotes apoptosis in TNBC.
Method    loss of function
in vitro    BT549, MDA-MB-468 and MDA-MB-231).
in vivo    4-week old female BALB/c nude mice
Interaction
Target    miR-34a
Type    circRNA-miRNA
Sample    BT549, MDA-MB-468 and MDA-MB-231).
Experiment    luciferase reporter assay, RIP
Description    In line with luciferase assays, our data confirmed that circGFRA1 functionally interacts with miR-34a and serves as a sponge for miR-34a.
ceRNA target    GFRA1
Reference
Pubmed ID    29037220
Trait/Disease    Breast Cancer
Title    circGFRA1 and GFRA1 act as ceRNAs in triple negative breast cancer by regulating miR-34a.
Authors    He R, Liu P, Xie X, Zhou Y, Liao Q, Xiong W, Li X, Li G, Zeng Z, Tang H.
Journal    J Exp Clin Cancer Res. 2017