RefCirc
a reference database for circRNAs validated by experiments

circWDR77 Details
Basic Information
circRNA    circWDR77
Alias    -
circBase ID    hsa_circ_0013509
Host gene    WDR77
Species    homo sapiens
Peptide    -
Sequence  GACAATAGAATTTTACTCTGGGATACCCGCTGTCCCAAGCCAGCATCACAGATTGGCTGCAGTGCGCCTGGCTACCTTCCTACCTCGCTGGCTTGGCATCCTCAGCAAAGTGAAGTCTTTGTCTTTGGTGATGAGAATGGGACAGTCTCCCTTGTGGACACCAAGAGTACAAGCTGTGTCCTGAGCTCAGCTGTACACTCCCAGTGTGTCACTGGGCTGGTGTTCTCCCCACACAGTGTTCCCTTCCTGGCCTCTCTCAGTGAAGACTGCTCACTTGCTGTGCTGGACTCAAGCCTTTCTGAGTT
Expression
Description  Expression of circWDR77 in high glucose treatment VSMCs was significantly up-regulated compared to normal group.
Method    microarray, qRT-PCR
Sample    vascular smooth muscle cells
Function
Description  circWDR77 regulated VSMCs proliferation and migration via targeting miR-124/FGF2.
Method    loss of function
in vitro    vascular smooth muscle cells
in vivo    -
Interaction
Target    miR-124
Type    circRNA-miRNA
Sample    vascular smooth muscle cells
Experiment    Luciferase reporter assay, RIP
Description    circWDR77 was targeted by miR-124 and represented opposite expression, suggesting the molecular sponge role of circWDR77 on miR-124.
ceRNA target    FGF2
Reference
Pubmed ID    29042195
Trait/Disease    -
Title    Circular RNA WDR77 target FGF-2 to regulate vascular smooth muscle cells proliferation and migration by sponging miR-124.
Authors    Chen J, Cui L, Yuan J, Zhang Y, Sang H.
Journal    Biochem Biophys Res Commun. 2017