RefCirc
a reference database for circRNAs validated by experiments

circBIRC6 Details
Basic Information
circRNA    circBIRC6
Alias    hsa_circ_002146
circBase ID    hsa_circ_0000989
Host gene    BIRC6
Species    homo sapiens
Peptide    -
Sequence  CTAAACCAGGTGGACAGGTGAAATGTCAGTATATCTCTGCTGTGGATAAAGTTATATTTGTGGATGATTATGCAGTAGGGTGTAGGAAGGACCTTAATGGAATCTTGTTGTTAGACACTGCTCTGCAAACTCCAGTTTCAAAGCAGGATGATGTGGTTCAGCTTGAATTACCCGTTACAGAGGCACAGCAGCTCTTATCAGCATGTTTAGAAAAGGTAGATATTTCTAGTACAGAGGGTTATGATTTGTTCATCACACAGCTCAAAGATGGTTTAAAAAATACATCTCATGAGACTGCAGCAAACCACAAAGTTGCTAAGTGGGCCACAGTTACATTTCATCTTCCTCATCATGTGTTGAAGTCCATTGCCAGTGCCATTGTAAATGAACTCAAGAAAATAAATCAAAATGTTGCTGCCTTACCTGTGGCGTCCTCAGTGATGGACAGATTGTCTTACCTCTTACCTAGTGCACGTCCAGAACTCGGAGTGGGGCCAGGCCGTTCTGTAGACAGATCACTGATGTATAGTGAAGCTAACAGACGGGAGACATTTACCTCATGGCCTCATGTAGGCTATAGGTGGGCACAACCAGATCCCATGGCTCAAGCTGGATTTTATCATCAGCCTGCCTCATCTGGAGATGATAGAGCCATGTGTTTTACTTGTAGTGTATGCCTCGTTTGTTGGGAACCTACTGATGAACCTTGGTCTGAACACGAAAGACATTCCCCAAACTGCCCATTTGTGAAAGGTGAGCACACACAGAATGTGCCATTGTCAGTCACTCTTGCAACAAGTCCTGCACAGTTTCCTTGTACGGATGGAACTGACAGAATATCTTGCTTTGGGTCGGGGAGCTGCCCTCATTTTCTAGCTGCTGCAACTAAACGAGGAAAGATCTGCATATGGGATGTTTCCAAACTTATGAAGGTGCACTTAAAGTTTGAAATTAATGCCTATGATCCAGCAATTGTACAACAGCTTATTCTATCAGGAGACCCAAGCTCAGGAGTTGATTCAAGGAGACCAACTTTGGCGTGGCTGGAGGACTCCTCTAGTTGCTCAGATATACCAAAATTGGAAGGAGATAGTGATGATTTACTGGAGGATTCAGACAGTGAAGAGCATTCCAGATCAGATTCTGTGACAG
Expression
Description  Eenriched in hESCs (>0.1% of GAPDH levels). Downregulated in Ebs, upregulated in induced pluripotent stem cells (iPSCs) as compared with the parental fibroblasts.
Method    qRT-PCR
Sample    Human embryonic stem cells, induced pluripotent stem cells
Function
Description  Disrupting circBIRC6 or circCORO1C impairs hESC pluripotency. Expressing circBIRC6 or circCORO1C retains hESC pluripotency. Expressing circBIRC6 or circCORO1C promotes reprogramming. CircBIRC6 acts as a sponge for miR-34a and miR-145 in hESCs.
Method    loss of function, gain of function
in vitro    Human embryonic stem cells
in vivo    -
Interaction
Target    miR-34a, miR-145
Type    circRNA-miRNA
Sample    Human embryonic stem cells
Experiment    qRT-PCR, luciferase reporter assays, northern blots
Description    circBIRC6 may exert its function through direct interactions with miR-34a and miR-145.
ceRNA target    miR-34a target genes (MDM4 and SIRT1) and miR-145 target genes (ADAM17 and NEDD9)
Reference
Pubmed ID    29074849
Trait/Disease    -
Title    The circular RNA circBIRC6 participates in the molecular circuitry controlling human pluripotency.
Authors    Yu CY, Li TC, Wu YY, Yeh CH, Chiang W, Chuang CY, Kuo HC.
Journal    Nat Commun. 2017