RefCirc
a reference database for circRNAs validated by experiments

hsa_circ_0009910 Details
Basic Information
circRNA    hsa_circ_0009910
Alias    -
circBase ID    hsa_circ_0009910
Host gene    MFN2
Species    homo sapiens
Peptide    -
Sequence  CGCAATGTCCCTGCTCTTCTCTCGATGCAACTCTATCGTCACAGTCAAGAAAAATAAGAGACACATGGCTGAGGTGAATGCATCCCCACTTAAGCACTTTGTCACTGCCAAGAAGAAGATCAATGGCATTTTTGAGCAGCTGGGGGCCTACATCCAGGAGAGCGCCACCTTCCTTGAAGACACGTACAGGAATGCAGAACTGGACCCCGTTACCACAGAAGAACAGGTTCTGGACGTCAAAGGTTACCTATCCAAAGTGAGAGGCATCAGTGAGGTGCTGGCTCGGAGGCACATGAAAGTGGCTTTTTTTGGCCG
Expression
Description  overexpressed in osteosarcoma
Method    qRT-PCR
Sample    hFOB, MG63, Saos-2 and U2OS, OS tissues and adjacent non-tumor tissues
Function
Description  Knockdown of circ_0009910 induced cell proliferation inhibition, cell cycle arrest, and apoptosis in OS cells.
Method    loss of function
in vitro    MG63
in vivo    -
Interaction
Target    miR-449a
Type    circRNA-miRNA
Sample    MG63
Experiment    luciferase reporter assay
Description    Direct interaction of circ_0009910 and miR-449a was confirmed through dual-luciferase assays.
ceRNA target    IL6R
Reference
Pubmed ID    29117539
Trait/Disease    Osteosarcoma
Title    Hsa_circ_0009910 promotes carcinogenesis by promoting the expression of miR-449a target IL6R in osteosarcoma.
Authors    Deng N, Li L, Gao J, Zhou J, Wang Y, Wang C, Liu Y.
Journal    Biochem Biophys Res Commun. 2018