RefCirc
a reference database for circRNAs validated by experiments

circPTK2 Details
Basic Information
circRNA    circPTK2
Alias    -
circBase ID    hsa_circ_0003221
Host gene    PTK2
Species    homo sapiens
Peptide    -
Sequence  AATATGACAGATACCTAGCATCTAGCAAAATAATGGCAGCTGCTTACCTTGACCCCAACTTGAATCACACACCAAATTCGAGTACTAAGACTCACCTGGGTACTGGTATGGAACGTTCTCCTGGTGCAATGGAGCGAGTATTAAAGGTCTTTCATTATTTTGAAAGCAATAGTGAGCCAACCACCTGGGCCAGTATTATCAGGCATGGAGATGCTACTGATGTCAGGGGCATCATTCAGAAGATAGTGGACAGTCACAAAGTAAAGCATGTGGCCTGCTATGGATTCCGCCTCAGTCACCTGCGGTCAGAGGAGGTTCACTGGCTTCACGTGGATATGGGCGTCTCCAGTGTGAGGGAGAAGTATGAGCTTGCTCACCCACCAGAGGAGTGGAAATATGAATTGAGAATTCGTTATTTGCCAAAAGGATTTCTAAACCAGTTTACTGAAGATAAGCCAACTTTGAATTTCTTCTATCAACAGGTGAAGAGCGATTATATGTTAGAGATAGCTGATCAAGTGGACCAGGAAATTGCTTTGAAGTTGGGTTGTCTAGAAATACGGCGATCATACTGGGAGATGCGGGGCAATGCACTAGAAAAGAAGTCTAACTATGAAGTATTAGA
Expression
Description  CircPTK2 is highly expressed in migrated cancer cells and in metastatic lymph nodes
Method    RNA-seq, qRT-PCR
Sample    bladder carcinoma tissue, matched para-carcinoma tissue, and metastatic lymph node tissue, T24 and 5637 cells
Function
Description  CircPTK2 overexpression promoted the proliferation and migration of bladder cancer cells. CircPTK2 knockdown inhibited the proliferation and migration of bladder cancer cells
Method    gain of function, loss of function
in vitro    5637 and T24 cells
in vivo    -
Interaction
Target    -
Type    -
Sample    -
Experiment    -
Description    -
ceRNA target    -
Reference
Pubmed ID    29125888
Trait/Disease    Bladder Cancer
Title    Circular RNA hsa_circ_0003221 (circPTK2) promotes the proliferation and migration of bladder cancer cells.
Authors    Xu ZQ, Yang MG, Liu HJ, Su CQ.
Journal    J Cell Biochem. 2018